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Conserved domains on  [gi|753122597|ref|WP_041491256|]
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MULTISPECIES: tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE [Burkholderia]

Protein Classification

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE( domain architecture ID 10002738)

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB

Gene Symbol:  tsaE
Gene Ontology:  GO:0002949|GO:0005524
PubMed:  36362385

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 24-182 6.70e-61

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440565  Cd Length: 146  Bit Score: 185.68  E-value: 6.70e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  24 LADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarDD 103
Cdd:COG0802    1 LPSEEETEALGARLAALLKP------------GDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEY----EL 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597 104 GELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGD-GRALTVRAFSASGKACLER 182
Cdd:COG0802   65 GRLPLYHFDLYRLEDPEELEDLGLEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEA 144
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 24-182 6.70e-61

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 185.68  E-value: 6.70e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  24 LADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarDD 103
Cdd:COG0802    1 LPSEEETEALGARLAALLKP------------GDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEY----EL 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597 104 GELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGD-GRALTVRAFSASGKACLER 182
Cdd:COG0802   65 GRLPLYHFDLYRLEDPEELEDLGLEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEA 144
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 24-165 7.83e-53

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 164.53  E-value: 7.83e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597   24 LADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarDD 103
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKP------------GDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEY----EG 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 753122597  104 GELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGDGR 165
Cdd:pfam02367  65 GGLPLYHFDLYRLEDPEELEDLGLEDYFDGDGVCLIEWPERIEELLPEDDLDIEIEREGEEG 126
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
19-182 4.63e-51

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 161.09  E-value: 4.63e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  19 ERVIALADEAATEAFGTRFAHALDAARgelarahafdglQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYA 98
Cdd:PRK10646   3 NRVIPLPDEQATLDLGARVAKACDGAT------------VIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  99 FArddgELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGDGRALTVRAFSASGKA 178
Cdd:PRK10646  71 LD----NLMVYHFDLYRLADPEELEFMGIRDYFANDAICLVEWPQQGAGVLPDPDVEIHLDYQAQGREARVSAVSSAGEL 146


                 ....
gi 753122597 179 CLER 182
Cdd:PRK10646 147 LLAR 150
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 23-171 3.28e-44

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 142.97  E-value: 3.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597   23 ALADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarD 102
Cdd:TIGR00150   1 ANPDEKAMDKFGKAFAKPLDF------------GTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEY----N 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 753122597  103 DGELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGDGRALTVRA 171
Cdd:TIGR00150  65 EGNLMVYHFDLYRLADPEELELMGLEDYFEGDGICLVEWPEEGLEILPDYDLQIKIDYVGDGREIELTA 133
ABC_Metallic_Cations cd03235
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...
 59-87 4.27e-03

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.


Pssm-ID: 213202 [Multi-domain]  Cd Length: 213  Bit Score: 36.36  E-value: 4.27e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 753122597  59 IQLIGDLGAGKTTLVRAILrGLGHP--GRVR 87
Cdd:cd03235   28 LAIVGPNGAGKSTLLKAIL-GLLKPtsGSIR 57
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 24-182 6.70e-61

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 185.68  E-value: 6.70e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  24 LADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarDD 103
Cdd:COG0802    1 LPSEEETEALGARLAALLKP------------GDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEY----EL 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597 104 GELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGD-GRALTVRAFSASGKACLER 182
Cdd:COG0802   65 GRLPLYHFDLYRLEDPEELEDLGLEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEA 144
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 24-165 7.83e-53

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 164.53  E-value: 7.83e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597   24 LADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarDD 103
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKP------------GDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEY----EG 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 753122597  104 GELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGDGR 165
Cdd:pfam02367  65 GGLPLYHFDLYRLEDPEELEDLGLEDYFDGDGVCLIEWPERIEELLPEDDLDIEIEREGEEG 126
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
19-182 4.63e-51

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 161.09  E-value: 4.63e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  19 ERVIALADEAATEAFGTRFAHALDAARgelarahafdglQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYA 98
Cdd:PRK10646   3 NRVIPLPDEQATLDLGARVAKACDGAT------------VIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597  99 FArddgELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGDGRALTVRAFSASGKA 178
Cdd:PRK10646  71 LD----NLMVYHFDLYRLADPEELEFMGIRDYFANDAICLVEWPQQGAGVLPDPDVEIHLDYQAQGREARVSAVSSAGEL 146


                 ....
gi 753122597 179 CLER 182
Cdd:PRK10646 147 LLAR 150
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 23-171 3.28e-44

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 142.97  E-value: 3.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753122597   23 ALADEAATEAFGTRFAHALDAargelarahafdGLQIQLIGDLGAGKTTLVRAILRGLGHPGRVRSPTYTLVEPYafarD 102
Cdd:TIGR00150   1 ANPDEKAMDKFGKAFAKPLDF------------GTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEY----N 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 753122597  103 DGELEVYHFDLYRFNDPAEWSDAGFREYFNSSAICLVEWPQQAGTLLGVPDLVFSLDVDGDGRALTVRA 171
Cdd:TIGR00150  65 EGNLMVYHFDLYRLADPEELELMGLEDYFEGDGICLVEWPEEGLEILPDYDLQIKIDYVGDGREIELTA 133
ABC_Metallic_Cations cd03235
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...
 59-87 4.27e-03

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.


Pssm-ID: 213202 [Multi-domain]  Cd Length: 213  Bit Score: 36.36  E-value: 4.27e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 753122597  59 IQLIGDLGAGKTTLVRAILrGLGHP--GRVR 87
Cdd:cd03235   28 LAIVGPNGAGKSTLLKAIL-GLLKPtsGSIR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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