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Conserved domains on  [gi|753847521|ref|WP_041603138|]
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helix-turn-helix domain-containing protein [Glaesserella parasuis]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-67 7.82e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.14  E-value: 7.82e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 753847521   1 MSFSERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGE 67
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADE 72
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-67 7.82e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.14  E-value: 7.82e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 753847521   1 MSFSERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGE 67
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADE 72
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 4-61 3.30e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 44.08  E-value: 3.30e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 753847521   4 SERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWL 61
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-47 1.74e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.12  E-value: 1.74e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 753847521     6 RLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVL 47
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETL 42
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 2-68 7.73e-05

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 40.49  E-value: 7.73e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 753847521   2 SFSERLKAVLKAKNLK----IRAFSDLtGIPYSTCQ--SYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGEM 68
Cdd:PRK13355   3 TFAERLKQAMKARGLKqedlVHAAEAR-GVKLGKSHisQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPA 74
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-67 1.01e-04

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 37.65  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 753847521    5 ERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGE 67
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGEGE 64
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-67 7.82e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.14  E-value: 7.82e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 753847521   1 MSFSERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGE 67
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADE 72
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 4-61 3.30e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 44.08  E-value: 3.30e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 753847521   4 SERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWL 61
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-47 1.74e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.12  E-value: 1.74e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 753847521     6 RLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVL 47
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETL 42
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 2-68 7.73e-05

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 40.49  E-value: 7.73e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 753847521   2 SFSERLKAVLKAKNLK----IRAFSDLtGIPYSTCQ--SYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGEM 68
Cdd:PRK13355   3 TFAERLKQAMKARGLKqedlVHAAEAR-GVKLGKSHisQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPA 74
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-67 1.01e-04

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 37.65  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 753847521    5 ERLKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWLLTGQGE 67
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGEGE 64
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-61 1.48e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 37.13  E-value: 1.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 753847521    7 LKAVLKAKNLKIRAFSDLTGIPYSTCQSYLNGTREPGMEVLTTIYLQLYVNINWL 61
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 5-69 1.42e-03

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 34.61  E-value: 1.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 753847521    5 ERLKAVLKAKNLKirAFSDLTGIPYSTCQSYLNGTREPGmEVLTTIYLQLYVNINWLLTGQGEMF 69
Cdd:pfam07022   4 ERLMKAYGFKSRQ--ELADHLGVSKSTLSTWYTRDSFPA-ELVVRCALETGVSLEWLATGDGELY 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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