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Conserved domains on  [gi|754130318|ref|WP_041762193|]
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MULTISPECIES: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Brevundimonas]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10013199)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

EC:  6.3.2.6
Gene Ontology:  GO:0005524|GO:0004639

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 3-242 3.69e-150

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


:

Pssm-ID: 181800  Cd Length: 238  Bit Score: 417.97  E-value: 3.69e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   3 SKRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLI 82
Cdd:PRK09362   2 EKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  83 REVEIIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDY 162
Cdd:PRK09362  82 KKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 163 LCGMFGAVGITLVDFKIEFGRVWENDfsrVILADEISPDSCRLWDTATGEKMDKDRFRRDLGQVIENYTEVARRLGIMKD 242
Cdd:PRK09362 162 LKGLFAGAGIRLVDFKLEFGRDKDGE---IVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELLE 238
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 3-242 3.69e-150

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 417.97  E-value: 3.69e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   3 SKRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLI 82
Cdd:PRK09362   2 EKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  83 REVEIIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDY 162
Cdd:PRK09362  82 KKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 163 LCGMFGAVGITLVDFKIEFGRVWENDfsrVILADEISPDSCRLWDTATGEKMDKDRFRRDLGQVIENYTEVARRLGIMKD 242
Cdd:PRK09362 162 LKGLFAGAGIRLVDFKLEFGRDKDGE---IVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELLE 238
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-239 1.12e-133

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 376.02  E-value: 1.12e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   7 KIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIREVE 86
Cdd:cd01415    1 LLYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  87 IIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYLCGM 166
Cdd:cd01415   81 IIPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754130318 167 FGAVGITLVDFKIEFGRvweNDFSRVILADEISPDSCRLWDTATGEKMDKDRFRRDLGQVIENYTEVARRLGI 239
Cdd:cd01415  161 FAEIGIILVDFKLEFGR---DKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 3-241 7.44e-121

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 343.99  E-value: 7.44e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   3 SKRKKIYEGKAKILYEGPEpGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLI 82
Cdd:COG0152    2 PKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREMLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  83 REVEIIPLEVVCRNIVAGSLATR--------LGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILA 154
Cdd:COG0152   81 KKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELRE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 155 TTVRVNDYLCGMFGAVGITLVDFKIEFGRVWENdfsRVILADEISPDSCRLWDTATGEKMDKDRFRRDLG-QVIENYTEV 233
Cdd:COG0152  161 LALKINERLSELAAERGIILVDTKLEFGRDADG---EIVLADEITPDSSRLWDADTYESLDKDRFRDWLGgNTSEAYIEV 237


                 ....*...
gi 754130318 234 ARRLGIMK 241
Cdd:COG0152  238 LERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-232 1.03e-115

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 330.48  E-value: 1.03e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318    7 KIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIREVE 86
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   87 IIPLEVVCRNIVAGSLATRL-GQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYLCG 165
Cdd:pfam01259  81 IIPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754130318  166 MFGAVGITLVDFKIEFGRVWENdfsRVILADEISPDSCRLWDTAT----GEKMDKDRFRRDLGQVIENYTE 232
Cdd:pfam01259 161 YAAERGIILVDTKLEFGLDSDG---EIVLADEITPDSSRFWDADTyeksQESLDKDRFRDDLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 4-235 5.06e-85

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 253.09  E-value: 5.06e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318    4 KRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIR 83
Cdd:TIGR00081   5 KRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREMLVK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   84 EVEIIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYL 163
Cdd:TIGR00081  85 KLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNEVL 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754130318  164 CGMFGAVGITLVDFKIEFGRvweNDFSRVILADEISPDSCRLWDTATGE----KMDKDRFRRDLGQVIENYTEVAR 235
Cdd:TIGR00081 165 KKYFDEKGIILVDFKLEFGL---DEEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETVAR 237
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 3-242 3.69e-150

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 417.97  E-value: 3.69e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   3 SKRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLI 82
Cdd:PRK09362   2 EKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  83 REVEIIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDY 162
Cdd:PRK09362  82 KKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 163 LCGMFGAVGITLVDFKIEFGRVWENDfsrVILADEISPDSCRLWDTATGEKMDKDRFRRDLGQVIENYTEVARRLGIMKD 242
Cdd:PRK09362 162 LKGLFAGAGIRLVDFKLEFGRDKDGE---IVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELLE 238
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-239 1.12e-133

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 376.02  E-value: 1.12e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   7 KIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIREVE 86
Cdd:cd01415    1 LLYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  87 IIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYLCGM 166
Cdd:cd01415   81 IIPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754130318 167 FGAVGITLVDFKIEFGRvweNDFSRVILADEISPDSCRLWDTATGEKMDKDRFRRDLGQVIENYTEVARRLGI 239
Cdd:cd01415  161 FAEIGIILVDFKLEFGR---DKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 3-241 7.44e-121

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 343.99  E-value: 7.44e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   3 SKRKKIYEGKAKILYEGPEpGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLI 82
Cdd:COG0152    2 PKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREMLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  83 REVEIIPLEVVCRNIVAGSLATR--------LGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILA 154
Cdd:COG0152   81 KKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELRE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 155 TTVRVNDYLCGMFGAVGITLVDFKIEFGRVWENdfsRVILADEISPDSCRLWDTATGEKMDKDRFRRDLG-QVIENYTEV 233
Cdd:COG0152  161 LALKINERLSELAAERGIILVDTKLEFGRDADG---EIVLADEITPDSSRLWDADTYESLDKDRFRDWLGgNTSEAYIEV 237


                 ....*...
gi 754130318 234 ARRLGIMK 241
Cdd:COG0152  238 LERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-232 1.03e-115

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 330.48  E-value: 1.03e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318    7 KIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIREVE 86
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   87 IIPLEVVCRNIVAGSLATRL-GQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYLCG 165
Cdd:pfam01259  81 IIPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754130318  166 MFGAVGITLVDFKIEFGRVWENdfsRVILADEISPDSCRLWDTAT----GEKMDKDRFRRDLGQVIENYTE 232
Cdd:pfam01259 161 YAAERGIILVDTKLEFGLDSDG---EIVLADEITPDSSRFWDADTyeksQESLDKDRFRDDLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 4-235 5.06e-85

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 253.09  E-value: 5.06e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318    4 KRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIR 83
Cdd:TIGR00081   5 KRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREMLVK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   84 EVEIIPLEVVCRNIVAGSLATRLGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYL 163
Cdd:TIGR00081  85 KLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNEVL 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754130318  164 CGMFGAVGITLVDFKIEFGRvweNDFSRVILADEISPDSCRLWDTATGE----KMDKDRFRRDLGQVIENYTEVAR 235
Cdd:TIGR00081 165 KKYFDEKGIILVDFKLEFGL---DEEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETVAR 237
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 7-238 1.40e-61

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 193.06  E-value: 1.40e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   7 KIYEGKAKILYEgPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIREVE 86
Cdd:cd00476    1 TLYRGKTKIVYE-TKDGVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  87 IIPLEVVCRNIVAGSLATRL-GQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITAFNWANTQEIDDILATTVRVNDYLCG 165
Cdd:cd00476   80 *IPLEVVVRNRATGSFVKRYgGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KELAVKINTVLKK 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754130318 166 MFGAVGITLVDFKIEFGRVWENDfsrVILADEISPDSCRLWDTATGEKM-DKDRFRRDLGQVIENYTEVARRLG 238
Cdd:cd00476  160 LFSPAGLELWDFKLEFGLDEEGE---IVLGDEISPDSSRLWRKGGEPYDkDLFRRRASLGQIIEKYEEVAELVR 230
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 6-237 4.00e-43

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 146.67  E-value: 4.00e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   6 KKIYEGKAKILYEGPE-PGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIGVTNHFIKRLNLREQLIRE 84
Cdd:cd01416    5 KKLIEGKTKIVYELPDqPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIARK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  85 VEIIPLEVVCRNIVAGSLATR-LGQEEGTPLPRSIIEFYYKKDELNDPMVTEEHI--TAFNWANT----QEIDDILATTV 157
Cdd:cd01416   85 CEMIPIEWVCRRIATGSFLKRnPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLleAKLNCGGLkigkKEVDIMTKSTI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 158 RVNDYLCGMFGAVGITLVDFKIEFGRvwENDFSRVILADEISPDSCRLWDTATGEKMDKDRFRRDLGQVIE--------N 229
Cdd:cd01416  165 AIFEILEKAWATQDCTLVDMKIEFGV--DVTTGEILLADVIDNDSWRLWPSGDKRLMKDKQVYRNLKEVTDealqevkkN 242


                 ....*...
gi 754130318 230 YTEVARRL 237
Cdd:cd01416  243 YEWVADKL 250
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 7-210 4.04e-20

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 86.83  E-value: 4.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   7 KIYEGKAKILYEgPEPGTLIQYFKDDATAFNAQKKATLEGKGVINNRISEFVMSRLNGIgVTNHFIK-------RLNLRE 79
Cdd:cd01414    1 LIYSGKVRDVYD-LGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDI-IPNHLIStdvedlpEIKEPE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  80 QLI------REVEIIPLEVVCRNIVAGSLATRL-------------GQEEGTPLPRSIIEFYYKKDELNDPMVTEEHITA 140
Cdd:cd01414   79 DPDgrsmvvKKAKPIPIECIVRGYLTGSGWKEYqkggtvcgiklpeGLREAQKLPEPIFTPSTKAEEGHDENISFEEAVE 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754130318 141 fnWANTQEIDDILATTVRVNDYLCGMFGAVGITLVDFKIEFGRVwENDfsRVILADEI-SPDSCRLWDTAT 210
Cdd:cd01414  159 --IIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLD-ENG--EIILIDEVlTPDSSRFWPADS 224
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 9-214 6.25e-10

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 58.68  E-value: 6.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   9 YEGKAKILYEGPEPGTLIQyfKDDATAFNaQKKATLEGKGVINNRISEFVMSRLNGIgVTNHFIKRLNLREQLIREVEII 88
Cdd:PLN02544  79 RRGKVRDIYDLGDYLVLVT--TDRQSAFD-RVLASIPFKGQVLNQTSAWWFNNTKHI-TPNALVSSPDPNVTIAKKCSVF 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  89 PLEVVCRNIVAGSLATRL------------------GQEEGTPLPRSIIEFYYKKDELNDPmVTEEHITAFNWANTQEID 150
Cdd:PLN02544 155 PVEFVVRGYMTGSTSTSLwtvynkgvrnycgndlpdGMVKNQKLPANILTPTTKAADHDVP-ISPEEIVEEGLMTQEDFD 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754130318 151 DILATTVRVNDYLCGMFGAVGITLVDFKIEFGRvwenDFSRVI-LADEI-SPDSCRLWDTATGEKM 214
Cdd:PLN02544 234 EVSSKALALFAFGQEVAAEHGLILVDTKYEFGK----DADGTIlLIDEVhTPDSSRYWLADSYEER 295
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 87-205 1.92e-07

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 51.22  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  87 IIPLEVVCRNIV--AGSLATRLGQ----------------EEGTPLPRSIIEFYYKKDElNDPMVTEEHITAFNWANTQE 148
Cdd:PRK13959 121 LIPLEVIFRNYVpvGSSLRDRIKEgkikpedlgldadewpEEGVKLPEPIVEFSTKYEE-QDRYLSRKEADEIAGLSRAE 199

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 754130318 149 IDDILATTVRVNDYLCGMFGAVGITLVDFKIEFGRVWENdfsRVILADEI-SPDSCRL 205
Cdd:PRK13959 200 IEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEER---EIRVVDVVgTFDENRF 254
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 6-225 2.00e-07

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 51.04  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318   6 KKIYEGKAKILYEGPEpGTLIQYFKDDATAFNaQKKATLEGKGVINNRISEFVMSRLNGIgVTNHFIKRLNLREQLIREV 85
Cdd:PRK12607  16 PNVYRGKVRDNYDLPD-GRRVMVATDRISAFD-RVLPAIPYKGQVLNQTAAFWFEATKDI-CPNHVLAVPDPNVVVGKRC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318  86 EIIPLEVVCRNIVAGSLAT--RLGQEE--GTPLP----------RSII-----EFYYKKDElndPmVTEEHITAFNWANT 146
Cdd:PRK12607  93 EPFPVEMVVRGYLAGSTWRlyKAGKREmyGVTLPdglrenqklpEPIItpttkAEEGGHDE---P-ISPEEILAQGLLTP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 147 QEIDDILATTVRVNDYLCGMFGAVGITLVDFKIEFGRVWENdfsRVILADEI-SPDSCRLWDTATGEkmdkDRFRRDLGQ 225
Cdd:PRK12607 169 EDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADG---RIVLIDEIhTPDSSRYWYADGYE----ERFAAGEPQ 241
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 135-237 8.77e-06

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 46.24  E-value: 8.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754130318 135 EEHITAFNWANTQEIDDILATTVRVNDYLCGMFGAVGITLVDFKIEFGRVWE-NDFSRVILADEI-SPDSCRLWDTATge 212
Cdd:PRK13960 198 EANYQAFNFSSADDIDLYEKLLKEGFKVISDALAKLDQIFVDTKFEFGYVTDaAGNEKLIYMDEVgTPDSSRIWDGAA-- 275

                         90       100
                 ....*....|....*....|....*
gi 754130318 213 kmdkdrfRRDlGQVIENYTEVARRL 237
Cdd:PRK13960 276 -------YRD-GKIVENSKEGFRQF 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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