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Conserved domains on  [gi|754155625|ref|WP_041779391|]
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NAD(P)/FAD-dependent oxidoreductase [Belliella baltica]

Protein Classification

protoporphyrinogen/coproporphyrinogen oxidase( domain architecture ID 11440906)

protoporphyrinogen/coproporphyrinogen oxidase is a FAD-dependent enzyme that catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX or the oxidation of coproporphyrinogen III to coproporphyrin III, respectively

CATH:  3.50.50.60|3.50.50.60|1.10.3110.10|3.90.660.20
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0006779|GO:0071949
PubMed:  10944103
SCOP:  4000128|3000055|4000128

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-406 1.41e-43

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 157.69  E-value: 1.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRY-----LDFEVLKLK 75
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELlrelgLGDELVWPN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  76 kfYPGALILKPGSSYtisdPLrnPSEILGMAFSPVGSFMDKLKIYKLTKSLQKKEIDEifnspnISTIQFLKDyGFSEKI 155
Cdd:COG1232   82 --TRKSYIYYGGKLH----PL--PQGPLALLRSPLLSLAGKLRALLELLAPRRPPGED------ESLAEFVRR-RFGREV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 156 ITNFFKPFFKGIF---LEnelKTSAR-MFQFVFKMFGEGFAAV------------------PENGMKAIPEYLKSKLKHT 213
Cdd:COG1232  147 YERLVEPLLEGVYagdPD---ELSADwAFPRLKRLELEHGSLIkgalalrkgakagevfgyLRGGLGTLVEALAEALEAG 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 214 ELKLNAPVTKIE----GHQVFLENGEVLHGDKIIIAGKSD---HLLPQLKGQIQ------PYRSVYNLYFSLEKSFLIRP 280
Cdd:COG1232  224 EIRLGTRVTAIEreggGWRVTTSDGETIEADAVVSATPAPalaRLLAPLPPEVAaalagiPYASVAVVALGFDRPDLPPP 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 281 --MIGLIP-DNKFLINNIVFMTDISKAYSKNGKALLSVSvIKPIQNTEKL----ENLVAI---ELEAISGIKAEyfkPIK 350
Cdd:COG1232  304 dgFGWLVPrDEGVPILAVTFSSNKWPHRAPDGKVLLRLE-VGGAGDPELWqlsdEELVALalaDLRKLLGIDAE---PVD 379

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 754155625 351 T-----------YEI--KEALPDVEDMKADLPftntkiydHIFLAGDYLLNGSINAAMTSGRKAVEALL 406
Cdd:COG1232  380 TrvvrwpkaypqYTVghLERVAAIREALAALP--------GLYLAGRAYDGVGLPDCIRSGREAAERIL 440
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-406 1.41e-43

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 157.69  E-value: 1.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRY-----LDFEVLKLK 75
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELlrelgLGDELVWPN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  76 kfYPGALILKPGSSYtisdPLrnPSEILGMAFSPVGSFMDKLKIYKLTKSLQKKEIDEifnspnISTIQFLKDyGFSEKI 155
Cdd:COG1232   82 --TRKSYIYYGGKLH----PL--PQGPLALLRSPLLSLAGKLRALLELLAPRRPPGED------ESLAEFVRR-RFGREV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 156 ITNFFKPFFKGIF---LEnelKTSAR-MFQFVFKMFGEGFAAV------------------PENGMKAIPEYLKSKLKHT 213
Cdd:COG1232  147 YERLVEPLLEGVYagdPD---ELSADwAFPRLKRLELEHGSLIkgalalrkgakagevfgyLRGGLGTLVEALAEALEAG 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 214 ELKLNAPVTKIE----GHQVFLENGEVLHGDKIIIAGKSD---HLLPQLKGQIQ------PYRSVYNLYFSLEKSFLIRP 280
Cdd:COG1232  224 EIRLGTRVTAIEreggGWRVTTSDGETIEADAVVSATPAPalaRLLAPLPPEVAaalagiPYASVAVVALGFDRPDLPPP 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 281 --MIGLIP-DNKFLINNIVFMTDISKAYSKNGKALLSVSvIKPIQNTEKL----ENLVAI---ELEAISGIKAEyfkPIK 350
Cdd:COG1232  304 dgFGWLVPrDEGVPILAVTFSSNKWPHRAPDGKVLLRLE-VGGAGDPELWqlsdEELVALalaDLRKLLGIDAE---PVD 379

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 754155625 351 T-----------YEI--KEALPDVEDMKADLPftntkiydHIFLAGDYLLNGSINAAMTSGRKAVEALL 406
Cdd:COG1232  380 TrvvrwpkaypqYTVghLERVAAIREALAALP--------GLYLAGRAYDGVGLPDCIRSGREAAERIL 440
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 10-406 7.80e-39

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 144.94  E-value: 7.80e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   10 ISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRYLD----FEVLKLKKFYPGALILK 85
Cdd:pfam01593   1 LAGLAAARELLRAGHDVTVLEARDRVGGRIRTVRDDGFLIELGAMWFHGAQPPLLALLKelglEDRLVLPDPAPFYTVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   86 PGSSYTISDPLRNPSEILGMAFSPVG-SFMDKLKIYKLtksLQKKEIDEIFNSPNIS---TIQFLKDYGFSEKIITNFF- 160
Cdd:pfam01593  81 AGGRRYPGDFRRVPAGWEGLLEFGRLlSIPEKLRLGLA---ALASDALDEFDLDDFSlaeSLLFLGRRGPGDVEVWDRLi 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  161 -------KPFFKGIFLEN--ELKTSARMFQFVFKMFGEGFAAVPENGMKAIPEYLKSKLKHTELKLNAPVTKI----EGH 227
Cdd:pfam01593 158 dpelfaaLPFASGAFAGDpsELSAGLALPLLWALLGEGGSLLLPRGGLGALPDALAAQLLGGDVRLNTRVRSIdregDGV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  228 QVFLENGEVLHGDKIIIAG-----KSDHLLPQLKGQIQ------PYRSVYNLYFSLEKSFLIRPMIGLIPDNKFLINNIV 296
Cdd:pfam01593 238 TVTLTDGEVIEADAVIVTVplgvlKRILFTPPLPPEKArairnlGYGPVNKVHLEFDRKFWPDLGLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  297 FMTDISKAYSKNGKALLSVSVIKPIQNTEKLENL-----VAIELEAISGI-KAEYFKPIK--------------TYEIKE 356
Cdd:pfam01593 318 FSWLTFPNRAPPGKGLLLLVYVGPGDRARELEGLsdeelLQAVLRDLRKLfGEEAPEPLRvlvsdwhtdpwprgSYSLPQ 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 754155625  357 ALPDVEDMKADLpftnTKIYDHIFLAGDY---LLNGSINAAMTSGRKAVEALL 406
Cdd:pfam01593 398 YGPGHDDYRPLA----RTPDPGLFFAGEHtstGYPGTVEGAIESGRRAARAVL 446
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 1-406 1.41e-19

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 90.29  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSG--INPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRYLDfEV-LKLKKF 77
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGpdADITLLEASDRLGGKIQTVRKDGFPIELGPESFLARKPSAPALVK-ELgLEDELV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  78 YPGA---LILKPGSSYTISdplrnPSEILGMAFSpvgsfMDKLKIYKLTKSLQKKEIDEIFNSP------NISTIQFLKD 148
Cdd:PRK11883  80 ANTTgqsYIYVNGKLHPIP-----PGTVMGIPTS-----IAPFLFAGLVSPIGKLRAAADLRPPrwkpgqDQSVGAFFRR 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 149 YgFSEKIITNFFKPFFKGIFLENELKTSARM-F-QF-------------VFKMFGEG-------FAAVpENGMKAIPEYL 206
Cdd:PRK11883 150 R-FGDEVVENLIEPLLSGIYAGDIDTLSLRAtFpQLaqaedkygsllrgMRKALPKEkkktkgvFGTL-KGGLQSLIEAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 207 KSKLKHTELKLNAPVTKIE----GHQVFLENGEVLHGDKIIIAGkSDHLLPQLKGQI--------QPYRSVYNLYFSLEK 274
Cdd:PRK11883 228 EEKLPAGTIHKGTPVTKIDksgdGYEIVLSNGGEIEADAVIVAV-PHPVLPSLFVAPpafalfktIPSTSVATVALAFPE 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 275 SFLIrpmiglIPDNkfliNNIVFMTDIS---KAY---SK-------NGKALLSVSVIKP-----IQNTEklENLVAIELE 336
Cdd:PRK11883 307 SATN------LPDG----TGFLVARNSDytiTACtwtSKkwphttpEGKVLLRLYVGRPgdeavVDATD--EELVAFVLA 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 337 AIS---GIKAEyfkPIKTY--EIKEALPD--------VEDMKADLPftntkIYDHIFLAGDYLLNGSINAAMTSGRKAVE 403
Cdd:PRK11883 375 DLSkvmGITGD---PEFTIvqRWKEAMPQygvghierVAELRAGLP-----HYPGLYVAGASFEGVGLPDCIAQAKRAAA 446


                 ...
gi 754155625 404 ALL 406
Cdd:PRK11883 447 RLL 449
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-406 2.23e-13

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 71.41  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625    3 VIVIGAGISGLIAAYELER----SGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEArryLDFevlkLKKFY 78
Cdd:TIGR00562   5 VVIIGGGISGLCAAYYLEKeipeLPVELTLVEASDRVGGKIQTVKEDGYLIERGPDSFLERKKSA---PDL----VKDLG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   79 PGALILKPGSSYTI----SDPLRN-PSEILGMAFSPVGSFMDKLKIykltkslqkkEIDEIFNSP---NISTIQFLKDYg 150
Cdd:TIGR00562  78 LEHVLVSDATGQRYvlvnRGKLMPvPTKIAPFVKTGLFSLGGKLRA----------GMDFIRPASpgkDESVEEFVRRR- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  151 FSEKIITNFFKPFFKGI----------------FLENELK--------------TSARMFQFVFKMFGEGFAAVpENGMK 200
Cdd:TIGR00562 147 FGDEVVENLIEPLLSGIyagdpsklslkstfpkFYQTEQKhgslilgmkktrnlPQGSGLQLTAKKQGQDFQTL-ATGLE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  201 AIPEYLKSKLKHTELKLNAPVTKIE--GHQVFLE--NGEVLHGDKIIIAG---KSDHLLPQLKG-------QIQ-PYRSV 265
Cdd:TIGR00562 226 TLPEEIEKRLKLTKVYKGTKVTKLShrGSNYTLEldNGVTVETDSVVVTAphkAAAGLLSELSNsasshldKIHsPPVAN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  266 YNLYFSLEKSFLIRPMIG-LIP-DNKFLINNIVFMTDISKAYSKNGKALLSVSV-------IKPIQNTEkLENLVAIELE 336
Cdd:TIGR00562 306 VNLGFPEGSVDGELEGFGfLISrSSKFAILGCIFTSKLFPNRAPPGKTLLTAYIggatdesIVDLSENE-IINIVLRDLK 384

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754155625  337 AISGIKAEyFKPIKTYEIKEALPDV----EDMKADLPFTNTKIYDHIFLAGDYLLNGSINAAMTSGRKAVEALL 406
Cdd:TIGR00562 385 KVLNINNE-PEMLCVTRWHRAIPQYhvghDQRLKEARELLESAYPGVFLTGNSFEGVGIPDCIDQGKAAASDVL 457
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-406 1.41e-43

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 157.69  E-value: 1.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRY-----LDFEVLKLK 75
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELlrelgLGDELVWPN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  76 kfYPGALILKPGSSYtisdPLrnPSEILGMAFSPVGSFMDKLKIYKLTKSLQKKEIDEifnspnISTIQFLKDyGFSEKI 155
Cdd:COG1232   82 --TRKSYIYYGGKLH----PL--PQGPLALLRSPLLSLAGKLRALLELLAPRRPPGED------ESLAEFVRR-RFGREV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 156 ITNFFKPFFKGIF---LEnelKTSAR-MFQFVFKMFGEGFAAV------------------PENGMKAIPEYLKSKLKHT 213
Cdd:COG1232  147 YERLVEPLLEGVYagdPD---ELSADwAFPRLKRLELEHGSLIkgalalrkgakagevfgyLRGGLGTLVEALAEALEAG 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 214 ELKLNAPVTKIE----GHQVFLENGEVLHGDKIIIAGKSD---HLLPQLKGQIQ------PYRSVYNLYFSLEKSFLIRP 280
Cdd:COG1232  224 EIRLGTRVTAIEreggGWRVTTSDGETIEADAVVSATPAPalaRLLAPLPPEVAaalagiPYASVAVVALGFDRPDLPPP 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 281 --MIGLIP-DNKFLINNIVFMTDISKAYSKNGKALLSVSvIKPIQNTEKL----ENLVAI---ELEAISGIKAEyfkPIK 350
Cdd:COG1232  304 dgFGWLVPrDEGVPILAVTFSSNKWPHRAPDGKVLLRLE-VGGAGDPELWqlsdEELVALalaDLRKLLGIDAE---PVD 379

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 754155625 351 T-----------YEI--KEALPDVEDMKADLPftntkiydHIFLAGDYLLNGSINAAMTSGRKAVEALL 406
Cdd:COG1232  380 TrvvrwpkaypqYTVghLERVAAIREALAALP--------GLYLAGRAYDGVGLPDCIRSGREAAERIL 440
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 10-406 7.80e-39

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 144.94  E-value: 7.80e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   10 ISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRYLD----FEVLKLKKFYPGALILK 85
Cdd:pfam01593   1 LAGLAAARELLRAGHDVTVLEARDRVGGRIRTVRDDGFLIELGAMWFHGAQPPLLALLKelglEDRLVLPDPAPFYTVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   86 PGSSYTISDPLRNPSEILGMAFSPVG-SFMDKLKIYKLtksLQKKEIDEIFNSPNIS---TIQFLKDYGFSEKIITNFF- 160
Cdd:pfam01593  81 AGGRRYPGDFRRVPAGWEGLLEFGRLlSIPEKLRLGLA---ALASDALDEFDLDDFSlaeSLLFLGRRGPGDVEVWDRLi 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  161 -------KPFFKGIFLEN--ELKTSARMFQFVFKMFGEGFAAVPENGMKAIPEYLKSKLKHTELKLNAPVTKI----EGH 227
Cdd:pfam01593 158 dpelfaaLPFASGAFAGDpsELSAGLALPLLWALLGEGGSLLLPRGGLGALPDALAAQLLGGDVRLNTRVRSIdregDGV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  228 QVFLENGEVLHGDKIIIAG-----KSDHLLPQLKGQIQ------PYRSVYNLYFSLEKSFLIRPMIGLIPDNKFLINNIV 296
Cdd:pfam01593 238 TVTLTDGEVIEADAVIVTVplgvlKRILFTPPLPPEKArairnlGYGPVNKVHLEFDRKFWPDLGLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  297 FMTDISKAYSKNGKALLSVSVIKPIQNTEKLENL-----VAIELEAISGI-KAEYFKPIK--------------TYEIKE 356
Cdd:pfam01593 318 FSWLTFPNRAPPGKGLLLLVYVGPGDRARELEGLsdeelLQAVLRDLRKLfGEEAPEPLRvlvsdwhtdpwprgSYSLPQ 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 754155625  357 ALPDVEDMKADLpftnTKIYDHIFLAGDY---LLNGSINAAMTSGRKAVEALL 406
Cdd:pfam01593 398 YGPGHDDYRPLA----RTPDPGLFFAGEHtstGYPGTVEGAIESGRRAARAVL 446
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
3-245 2.95e-26

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 109.63  E-value: 2.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATD--DVDGFLLDRGFQVLLTAYPEARRYLDfEV-LKLKKFYP 79
Cdd:COG1231   10 VVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGGRVWTLrfGDDGLYAELGAMRIPPSHTNLLALAR-ELgLPLEPFPN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  80 G---ALILKPGSSYTISDPLRnpseilgmAFSPVGSFMDKLkIYKLTKSLQ-----KKEIDeifnspNISTIQFLKDYGF 151
Cdd:COG1231   89 EngnALLYLGGKRVRAGEIAA--------DLRGVAELLAKL-LRALAAALDpwahpAAELD------RESLAEWLRRNGA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 152 SEKIITNFfkpffkGIFLENELKTSAR---MFQFVFKMFGEGFAA---VPENGMKAIPEYLKSKLKHTeLKLNAPVTKIE 225
Cdd:COG1231  154 SPSARRLL------GLLGAGEYGADPDelsLLDLLRYAASAGGGAqqfRIVGGMDQLPRALAAELGDR-IRLGAPVTRIR 226

                        250       260
                 ....*....|....*....|....
gi 754155625 226 ----GHQVFLENGEVLHGDKIIIA 245
Cdd:COG1231  227 qdgdGVTVTTDDGGTVRADAVIVT 250
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-406 4.29e-25

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 106.48  E-value: 4.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVA--TDDVDGFLLDRGFQVLLTAYPEARRYL------DFEVL 72
Cdd:COG3349    4 PRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGGRARsfPDPDTGLPIDNGQHVLLGCYRNTLDLLrrigaaDNLVG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  73 KLKKFYP----GALILKPGssytisdPLRNPSEILGMAFSPVG-SFMDKLKIYKLTKSLQKKEIDEifnSPNISTIQFLK 147
Cdd:COG3349   84 PEPLQFPlpggRRWTLRAP-------RLPAPLHLLRALLRAPGlSLADRLALLRLLTACRERRWRE---LDDISVADWLR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 148 DYGFSEKIITNFFKPFFKGI-FLENElKTSARMFqfvFKMFGEGFAAVPENGMKAIP-------------EYLKSKlkHT 213
Cdd:COG3349  154 RHGQSPRLIRRLWEPLLLAAlNTPPE-QASARLA---LTVLRETLLAGPAASDLLVPrgplselfvdpalAYLEAR--GG 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 214 ELKLNAPVTKIEGHQ-----VFLENGEVLHGDKIIIAGKSDH---LLPQLK-----GQIQP--YRSVYNLYFSLEKSFLI 278
Cdd:COG3349  228 EVRLGTRVRALEFDGgrvtgLVLADGETVPADAVVLAVPPEVaarLLPELArlpelGLLAPleYSPIVNVHLWLDRPVTL 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 279 --RPMIGLIpdnkfliNNIVFMTDISKAYSKNGKALLSVsVIKP-----IQNTEKLENLVAIELEAISGIKAEYfKPIKT 351
Cdd:COG3349  308 gpPPFAGLV-------GSTSQWVFDRGAGDGGQGGVLSV-VISAadrllDLSREELAAEVWAELAALLPAAREA-LPVWS 378

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754155625 352 YEIKE------ALPDVEdmkADLPFTNTKIyDHIFLAGDYL---LNGSINAAMTSGRKAVEALL 406
Cdd:COG3349  379 RVVREkratfaATPGSD---RLRPGARTPI-PNLFLAGDWTatgLPATMEGAVRSGRRAANAIL 438
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 1-406 1.41e-19

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 90.29  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSG--INPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRYLDfEV-LKLKKF 77
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGpdADITLLEASDRLGGKIQTVRKDGFPIELGPESFLARKPSAPALVK-ELgLEDELV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  78 YPGA---LILKPGSSYTISdplrnPSEILGMAFSpvgsfMDKLKIYKLTKSLQKKEIDEIFNSP------NISTIQFLKD 148
Cdd:PRK11883  80 ANTTgqsYIYVNGKLHPIP-----PGTVMGIPTS-----IAPFLFAGLVSPIGKLRAAADLRPPrwkpgqDQSVGAFFRR 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 149 YgFSEKIITNFFKPFFKGIFLENELKTSARM-F-QF-------------VFKMFGEG-------FAAVpENGMKAIPEYL 206
Cdd:PRK11883 150 R-FGDEVVENLIEPLLSGIYAGDIDTLSLRAtFpQLaqaedkygsllrgMRKALPKEkkktkgvFGTL-KGGLQSLIEAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 207 KSKLKHTELKLNAPVTKIE----GHQVFLENGEVLHGDKIIIAGkSDHLLPQLKGQI--------QPYRSVYNLYFSLEK 274
Cdd:PRK11883 228 EEKLPAGTIHKGTPVTKIDksgdGYEIVLSNGGEIEADAVIVAV-PHPVLPSLFVAPpafalfktIPSTSVATVALAFPE 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 275 SFLIrpmiglIPDNkfliNNIVFMTDIS---KAY---SK-------NGKALLSVSVIKP-----IQNTEklENLVAIELE 336
Cdd:PRK11883 307 SATN------LPDG----TGFLVARNSDytiTACtwtSKkwphttpEGKVLLRLYVGRPgdeavVDATD--EELVAFVLA 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 337 AIS---GIKAEyfkPIKTY--EIKEALPD--------VEDMKADLPftntkIYDHIFLAGDYLLNGSINAAMTSGRKAVE 403
Cdd:PRK11883 375 DLSkvmGITGD---PEFTIvqRWKEAMPQygvghierVAELRAGLP-----HYPGLYVAGASFEGVGLPDCIAQAKRAAA 446


                 ...
gi 754155625 404 ALL 406
Cdd:PRK11883 447 RLL 449
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 3-305 2.63e-19

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 89.52  E-value: 2.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRG--FQVLLTAYPEARRYLD----FEVLKLKK 76
Cdd:COG1233    6 VVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFERPGFRFDVGpsVLTMPGVLERLFRELGledyLELVPLDP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  77 FYpgALILKPGSSYTI-SDPLRNPSEILgmAFSPvGSFMDKLKIYKLTKSLQKKEIDEIFNSPNISTIQFLKDYGFSE-- 153
Cdd:COG1233   86 AY--RVPFPDGRALDLpRDLERTAAELE--RLFP-GDAEAYRRFLAELRRLYDALLEDLLYRPLLSLRDLLRPLALARll 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 154 --------KIITNFFK-PFFKGIFLENEL-------KTSARMFQFVFKMFGEGfAAVPENGMKAIPEYLKSKLKHT--EL 215
Cdd:COG1233  161 rlllrslrDLLRRYFKdPRLRALLAGQALylglspdRTPALYALIAYLEYAGG-VWYPKGGMGALADALARLAEELggEI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 216 KLNAPVTKIEGHQ-----VFLENGEVLHGDKIIIAG----------KSDHLLPQLKGQIQPYR---SVYNLYFSLEKSFl 277
Cdd:COG1233  240 RTGAEVERILVEGgratgVRLADGEEIRADAVVSNAdpahtylrllGEEALPARYRRRLERFRyspSAFKLYLGLDGPL- 318

                        330       340
                 ....*....|....*....|....*...
gi 754155625 278 irpmigliPDnkFLINNIVFMTDISKAY 305
Cdd:COG1233  319 --------PG--LAHHTIHLSEDYEAAF 336
PRK07233 PRK07233
hypothetical protein; Provisional
 2-246 2.04e-16

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 80.70  E-value: 2.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLL---TAYPEARRYLDFEvlklkkfy 78
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGLAASFEFGGLPIERFYHHIFksdEALLELLDELGLE-------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  79 pGALILKPGSSYTISD----PLRNPSEILgmAFSPVgSFMDKLKIYKLTKSLQK----KEIDeifnspNISTIQFLKD-Y 149
Cdd:PRK07233  73 -DKLRWRETKTGYYVDgklyPLGTPLELL--RFPHL-SLIDKFRLGLLTLLARRikdwRALD------KVPAEEWLRRwS 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 150 GfsEKIITNFFKPFFKGIFLENELKTSA--------RMFQFVFKMFGE--GFaavPENGMKAIPEYLKSKL--KHTELKL 217
Cdd:PRK07233 143 G--EGVYEVFWEPLLESKFGDYADDVSAawlwsrikRRGNRRYSLFGEklGY---LEGGFATLIDALAEAIeaRGGEIRL 217

                        250       260       270
                 ....*....|....*....|....*....|...
gi 754155625 218 NAPVTKI----EGHQVFLENGEVLHGDKIIIAG 246
Cdd:PRK07233 218 GTPVTSVvidgGGVTGVEVDGEEEDFDAVISTA 250
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
5-68 2.08e-15

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 70.25  E-value: 2.08e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754155625    5 VIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTA-YPEARRYLD 68
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVPGYVFDYGAHIFHGSdEPNVRDLLD 65
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-406 2.23e-13

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 71.41  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625    3 VIVIGAGISGLIAAYELER----SGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEArryLDFevlkLKKFY 78
Cdd:TIGR00562   5 VVIIGGGISGLCAAYYLEKeipeLPVELTLVEASDRVGGKIQTVKEDGYLIERGPDSFLERKKSA---PDL----VKDLG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   79 PGALILKPGSSYTI----SDPLRN-PSEILGMAFSPVGSFMDKLKIykltkslqkkEIDEIFNSP---NISTIQFLKDYg 150
Cdd:TIGR00562  78 LEHVLVSDATGQRYvlvnRGKLMPvPTKIAPFVKTGLFSLGGKLRA----------GMDFIRPASpgkDESVEEFVRRR- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  151 FSEKIITNFFKPFFKGI----------------FLENELK--------------TSARMFQFVFKMFGEGFAAVpENGMK 200
Cdd:TIGR00562 147 FGDEVVENLIEPLLSGIyagdpsklslkstfpkFYQTEQKhgslilgmkktrnlPQGSGLQLTAKKQGQDFQTL-ATGLE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  201 AIPEYLKSKLKHTELKLNAPVTKIE--GHQVFLE--NGEVLHGDKIIIAG---KSDHLLPQLKG-------QIQ-PYRSV 265
Cdd:TIGR00562 226 TLPEEIEKRLKLTKVYKGTKVTKLShrGSNYTLEldNGVTVETDSVVVTAphkAAAGLLSELSNsasshldKIHsPPVAN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  266 YNLYFSLEKSFLIRPMIG-LIP-DNKFLINNIVFMTDISKAYSKNGKALLSVSV-------IKPIQNTEkLENLVAIELE 336
Cdd:TIGR00562 306 VNLGFPEGSVDGELEGFGfLISrSSKFAILGCIFTSKLFPNRAPPGKTLLTAYIggatdesIVDLSENE-IINIVLRDLK 384

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754155625  337 AISGIKAEyFKPIKTYEIKEALPDV----EDMKADLPFTNTKIYDHIFLAGDYLLNGSINAAMTSGRKAVEALL 406
Cdd:TIGR00562 385 KVLNINNE-PEMLCVTRWHRAIPQYhvghDQRLKEARELLESAYPGVFLTGNSFEGVGIPDCIDQGKAAASDVL 457
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-56 4.36e-13

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 69.52  E-value: 4.36e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVL 56
Cdd:COG3380    4 PDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDGGRFDHGAQYF 59
PRK07208 PRK07208
hypothetical protein; Provisional
 2-52 1.10e-10

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 62.98  E-value: 1.10e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRG 52
Cdd:PRK07208   6 SVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGISRTVTYKGNRFDIG 56
PLN02268 PLN02268
probable polyamine oxidase
 3-52 1.25e-10

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 62.78  E-value: 1.25e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRG 52
Cdd:PLN02268   3 VIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSFGFPVDMG 52
PLN02576 PLN02576
protoporphyrinogen oxidase
 2-68 1.51e-09

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 59.64  E-value: 1.51e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754155625   2 NVIVIGAGISGLIAAYEL-ERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLTAYPEARRYLD 68
Cdd:PLN02576  14 DVAVVGAGVSGLAAAYALaSKHGVNVLVTEARDRVGGNITSVSEDGFIWEEGPNSFQPSDPELTSAVD 81
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 3-37 2.25e-09

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 58.72  E-value: 2.25e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGG 43
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 3-78 1.53e-08

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 56.52  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625    3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLtaYPEARRYL----------DFEVL 72
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGRAGVLEDDGFRFDTGPTVIT--MPEALEELfalagrdladYVELV 78


                  ....*.
gi 754155625   73 KLKKFY 78
Cdd:TIGR02734  79 PLDPFY 84
PLN02976 PLN02976
amine oxidase
 3-42 1.56e-08

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 56.80  E-value: 1.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 754155625    3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATD 42
Cdd:PLN02976  696 IIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTD 735
PLN02676 PLN02676
polyamine oxidase
 3-46 2.94e-08

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 55.49  E-value: 2.94e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPIL-LEASDRVGGRVATDDVDG 46
Cdd:PLN02676  29 VIIVGAGMSGISAAKTLSEAGIEDILiLEATDRIGGRMRKANFAG 73
PLN02612 PLN02612
phytoene desaturase
 1-61 4.73e-07

phytoene desaturase


Pssm-ID: 215330 [Multi-domain]  Cd Length: 567  Bit Score: 51.77  E-value: 4.73e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVAT-DDVDGFLLDRGFQVLLTAYP 61
Cdd:PLN02612  94 LKVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGGKVAAwKDEDGDWYETGLHIFFGAYP 155
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-55 6.51e-07

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 51.27  E-value: 6.51e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   1 MNVIVIGAGISGLIAAYELERSgiNPI-LLEASDRVGGRVATDDVDG----FLLDRGFQV 55
Cdd:COG2907    4 MRIAVIGSGISGLTAAWLLSRR--HDVtLFEANDRLGGHTHTVDVDLdgrtVPVDTGFIV 61
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 3-37 1.40e-06

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 49.70  E-value: 1.40e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 754155625    3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGS 36
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-56 1.75e-06

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 49.55  E-value: 1.75e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDvdgfLLDRGFQVL 56
Cdd:COG0654    4 TDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIA----LSPRSLELL 55
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 2-46 2.54e-06

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 49.61  E-value: 2.54e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDG 46
Cdd:PLN02328 240 NVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRVKTMKMKG 284
PLN03000 PLN03000
amine oxidase
 2-46 4.17e-06

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 49.25  E-value: 4.17e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVATDDVDG 46
Cdd:PLN03000 186 SVVIVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKMEA 230
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-37 1.25e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.82  E-value: 1.25e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEAsDRVGG 37
Cdd:COG0665    3 ADVVVIGGGIAGLSTAYHLARRGLDVTVLER-GRPGS 38
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
2-40 1.30e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 47.16  E-value: 1.30e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVA 40
Cdd:COG1148  142 RALVIGGGIAGMTAALELAEQGYEVYLVEKEPELGGRAA 180
PLN02568 PLN02568
polyamine oxidase
 3-46 4.03e-05

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 45.59  E-value: 4.03e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 754155625   3 VIVIGAGISGLIAAYELERSGINP-----ILLEASDRVGGRVATDDVDG 46
Cdd:PLN02568   8 IVIIGAGMAGLTAANKLYTSSAANdmfelTVVEGGDRIGGRINTSEFGG 56
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-47 4.22e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 45.11  E-value: 4.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEAsDRVGGRVAT----DDVDGF 47
Cdd:COG0492    3 VVIIGAGPAGLTAAIYAARAGLKTLVIEG-GEPGGQLATtkeiENYPGF 50
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
2-37 1.52e-04

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 44.01  E-value: 1.52e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILL--EASDRVGG 37
Cdd:COG3573    7 DVIVVGAGLAGLVAAAELADAGRRVLLLdqEPEANLGG 44
PRK12834 PRK12834
putative FAD-binding dehydrogenase; Reviewed
 2-37 1.57e-04

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 183782 [Multi-domain]  Cd Length: 549  Bit Score: 43.73  E-value: 1.57e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILL--EASDRVGG 37
Cdd:PRK12834   6 DVIVVGAGLAGLVAAAELADAGKRVLLLdqENEANLGG 43
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 3-37 1.99e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 43.28  E-value: 1.99e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:COG1053    6 VVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGG 40
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 3-408 4.39e-04

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 42.51  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625   3 VIVIGAGISGLIAAYELERS------GINPILLEASDRVGGRVATDDVDGFLLDRGFQVLLtaypeARRYLDFEVLKLKK 76
Cdd:PRK12416   4 VVVIGGGITGLSTMFYLEKLkkdyniDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIV-----ARNEHVMPLVKDLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625  77 FYPGALILKPGSSYTISDPLRNP---SEILGMAFSPVGSFMDKL-----KIYKLT-------------------KSLQKK 129
Cdd:PRK12416  79 LEEEMVYNETGISYIYSDNTLHPipsDTIFGIPMSVESLFSSTLvstkgKIVALKdfitknkeftkdtslalflESFLGK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 130 EIDEIFNSPNI--------------STIQFLKDYgfsekiiTNFFKPFFKGiFLENELK-TSARMFQFV-FKmfgegfaa 193
Cdd:PRK12416 159 ELVERQIAPVLsgvysgklneltmaSTLPYLLDY-------KNKYGSIIKG-FEENKKQfQSAGNKKFVsFK-------- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 194 vpeNGMKAIPEYLKSKLKHTELKLNAPVTKI----EGHQVFLENGEVLHGDKIIIAGKSD---HLL--PQLKGQIQPYR- 263
Cdd:PRK12416 223 ---GGLSTIIDRLEEVLTETVVKKGAVTTAVskqgDRYEISFANHESIQADYVVLAAPHDiaeTLLqsNELNEQFHTFKn 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 264 ----SVYnLYFSLEKSFLIRPMIGLI-PDNKFLINNIVFMTDIS-KAYSKNGKALLSVSVIKPIQNTEKL-----ENLVA 332
Cdd:PRK12416 300 ssliSIY-LGFDILDEQLPADGTGFIvTENSDLHCDACTWTSRKwKHTSGKQKLLVRMFYKSTNPVYETIknyseEELVR 378

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625 333 IELEAIS---GIKAE--------YFKPIKTYEIK--EALPDVEDMKADLpftntkiYDHIFLAGDYLLNGSINAAMTSGR 399
Cdd:PRK12416 379 VALYDIEkslGIKGEpevvevtnWKDLMPKYHLEhnQAVQSLQEKMMNL-------YPNIYLAGASYYGVGIGACIGNGK 451


                 ....*....
gi 754155625 400 KAVEALLLT 408
Cdd:PRK12416 452 NTANEIIAT 460
PLN02529 PLN02529
lysine-specific histone demethylase 1
 2-41 6.18e-04

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 42.19  E-value: 6.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVAT 41
Cdd:PLN02529 162 SVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYT 201
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 1-85 1.05e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 40.77  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754155625    1 MNVIVIGAGISGLIAAYELERSGINPILLEASD--RV---GGRVATDDVDGFLLDRGFQVLLTAypEARRYLDF-EVLKL 74
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGLRVLLLEKKSfpRYkpcGGALSPRALEELDLPGELIVNLVR--GARFFSPNgDSVEI 78

                          90
                  ....*....|.
gi 754155625   75 KKFYPGALILK 85
Cdd:TIGR02032  79 PIETELAYVID 89
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-37 1.14e-03

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 41.00  E-value: 1.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:PLN02172  12 HVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGG 47
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 3-37 1.71e-03

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 40.35  E-value: 1.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 754155625    3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:pfam00890   2 VLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGG 36
PRK12843 PRK12843
FAD-dependent oxidoreductase;
2-41 1.76e-03

FAD-dependent oxidoreductase;


Pssm-ID: 237225 [Multi-domain]  Cd Length: 578  Bit Score: 40.49  E-value: 1.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVAT 41
Cdd:PRK12843  18 DVIVIGAGAAGMSAALFAAIAGLKVLLVERTEYVGGTTAT 57
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-37 1.81e-03

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 40.12  E-value: 1.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:COG0493  124 VAVVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG 158
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
3-36 2.08e-03

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 40.13  E-value: 2.08e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 754155625   3 VIVIGAGISGLIAAYEL-ERSGINPILLEASDRVG 36
Cdd:COG0579    7 VVIIGAGIVGLALARELsRYEDLKVLVLEKEDDVA 41
PRK08132 PRK08132
FAD-dependent oxidoreductase; Provisional
 3-36 2.18e-03

FAD-dependent oxidoreductase; Provisional


Pssm-ID: 236158 [Multi-domain]  Cd Length: 547  Bit Score: 40.24  E-value: 2.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVG 36
Cdd:PRK08132  26 VVVVGAGPVGLALAIDLAQQGVPVVLLDDDDTLS 59
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-37 2.27e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 40.15  E-value: 2.27e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 754155625   3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGG 37
Cdd:PRK12810 146 VAVVGSGPAGLAAADQLARAGHKVTVFERADRIGG 180
PRK06847 PRK06847
hypothetical protein; Provisional
 2-37 2.74e-03

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 39.47  E-value: 2.74e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 754155625   2 NVIVIGAGISGLIAAYELERSGINPILLEASD--RVGG 37
Cdd:PRK06847   6 KVLIVGGGIGGLSAAIALRRAGIAVDLVEIDPewRVYG 43
Thi4 pfam01946
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
 1-37 6.04e-03

Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.


Pssm-ID: 460393  Cd Length: 232  Bit Score: 37.84  E-value: 6.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 754155625    1 MNVIVIGAGISGLIAAYEL-ERSGINPILLEASDRVGG 37
Cdd:pfam01946  18 SDVVIVGAGSSGLTAAYYLaKNRGLKVAIIERSVSPGG 55
PRK07588 PRK07588
FAD-binding domain;
1-39 6.83e-03

FAD-binding domain;


Pssm-ID: 169028 [Multi-domain]  Cd Length: 391  Bit Score: 38.56  E-value: 6.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 754155625   1 MNVIVIGAGISGLIAAYELERSGINPILLEASD--RVGGRV 39
Cdd:PRK07588   1 MKVAISGAGIAGPTLAYWLRRYGHEPTLIERAPelRTGGYM 41
PTZ00306 PTZ00306
NADH-dependent fumarate reductase; Provisional
 3-40 9.77e-03

NADH-dependent fumarate reductase; Provisional


Pssm-ID: 140327 [Multi-domain]  Cd Length: 1167  Bit Score: 38.22  E-value: 9.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 754155625    3 VIVIGAGISGLIAAYELERSGINPILLEASDRVGGRVA 40
Cdd:PTZ00306  412 VIVVGGGLAGCSAAIEAASCGAQVILLEKEAKLGGNSA 449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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