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Conserved domains on  [gi|754493224|ref|WP_041910119|]
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MULTISPECIES: cyclopropane-fatty-acyl-phospholipid synthase family protein [Enterobacter]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 11454891)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-
Gene Ontology:  GO:0032259|GO:0008757|GO:1904047|GO:0008168
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CMAS super family cl47167
Mycolic acid cyclopropane synthetase; This family consist of ...
 129-401 2.83e-97

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


The actual alignment was detected with superfamily member pfam02353:

Pssm-ID: 481507 [Multi-domain]  Cd Length: 272  Bit Score: 291.54  E-value: 2.83e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  129 SRAQARENIAAHYDLGNAFYAHFLDKELLYSSALFTADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAA 208
Cdd:pfam02353   1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  209 RHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGR 288
Cdd:pfam02353  81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  289 MAIQAITIQDQRYR-DYSKSVDFIQRYIFPGGFLPSITAMNELMtRHTDFVVRNLFDMGPDYARTLAHWRQRFVHAWQEI 367
Cdd:pfam02353 161 MLLHTITGLHPDETsERGLPLKFIDKYIFPGGELPSISMIVESS-SEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEA 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 754493224  368 EKLgFDERFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:pfam02353 240 IAL-QSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
 
Name Accession Description Interval E-value
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 129-401 2.83e-97

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 291.54  E-value: 2.83e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  129 SRAQARENIAAHYDLGNAFYAHFLDKELLYSSALFTADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAA 208
Cdd:pfam02353   1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  209 RHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGR 288
Cdd:pfam02353  81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  289 MAIQAITIQDQRYR-DYSKSVDFIQRYIFPGGFLPSITAMNELMtRHTDFVVRNLFDMGPDYARTLAHWRQRFVHAWQEI 367
Cdd:pfam02353 161 MLLHTITGLHPDETsERGLPLKFIDKYIFPGGELPSISMIVESS-SEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEA 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 754493224  368 EKLgFDERFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:pfam02353 240 IAL-QSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
56-401 8.56e-90

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 276.34  E-value: 8.56e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  56 DVQILTPGVYWRVLTGGSLAAAEAWMDGEWETAQLTPLLQILaLNGEVLGRLENGFRLLgrpLERLRH-WTRRNSRAQAR 134
Cdd:PRK11705  38 DIQVHNPRFFKRVLQEGSLGLGESYMDGWWDCDRLDEFFSRV-LRAGLDEKLPHHLKDT---LRILRArLFNLQSKKRAW 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 135 ENIAAHYDLGNAFYAHFLDKELLYSSALFtADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYGCR 214
Cdd:PRK11705 114 IVGKEHYDLGNDLFEAMLDPRMQYSCGYW-KDADTLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 215 VTTTTLSQEQYIWATERiaRAGLQdrVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQAI 294
Cdd:PRK11705 193 VVGVTISAEQQKLAQER--CAGLP--VEIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 295 TiqdqRYRDYSKSVDFIQRYIFPGGFLPSITAMNELMTRHtdFVVRNLFDMGPDYARTLAHWRQRFVHAWQEIEKlGFDE 374
Cdd:PRK11705 269 G----SNKTDTNVDPWINKYIFPNGCLPSVRQIAQASEGL--FVMEDWHNFGADYDRTLMAWHENFEAAWPELAD-NYSE 341

                        330       340
                 ....*....|....*....|....*..
gi 754493224 375 RFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:PRK11705 342 RFYRMWRYYLLSCAGAFRARDIQLWQV 368
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 139-293 2.53e-73

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 225.96  E-value: 2.53e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 139 AHYDLGNAFYAHFLDKELLYSSALFTADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYGCRVTTT 218
Cdd:COG2230    1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754493224 219 TLSQEQYIWATERIARAGLQDRVEVLLCDYRDL--TGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQA 293
Cdd:COG2230   81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 193-292 2.20e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.44  E-value: 2.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 193 LLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQyIWATERIARAGLQDRVEVLLCDYRDLT----GQYDKLVSIEMIEAVG 268
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVA-LELARKAAAALLADNVEVLKGDAEELPpeadESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 754493224 269 QRYLPtFFRTCQARLRPGGRMAIQ 292
Cdd:cd02440   81 EDLAR-FLEEARRLLKPGGVLVLT 103
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
192-289 3.56e-03

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 38.55  E-value: 3.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224   192 HLLEIGTGWGA-MAEYAARHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLlcdYRDLT-----GQYDKLVSIEMIE 265
Cdd:smart00828   2 RVLDFGCGYGSdLIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIF---YRDSAkdpfpDTYDLVFGFEVIH 78

                           90       100
                   ....*....|....*....|....
gi 754493224   266 AVGQRYLptFFRTCQARLRPGGRM 289
Cdd:smart00828  79 HIKDKMD--LFSNISRHLKDGGHL 100
 
Name Accession Description Interval E-value
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 129-401 2.83e-97

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 291.54  E-value: 2.83e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  129 SRAQARENIAAHYDLGNAFYAHFLDKELLYSSALFTADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAA 208
Cdd:pfam02353   1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  209 RHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGR 288
Cdd:pfam02353  81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  289 MAIQAITIQDQRYR-DYSKSVDFIQRYIFPGGFLPSITAMNELMtRHTDFVVRNLFDMGPDYARTLAHWRQRFVHAWQEI 367
Cdd:pfam02353 161 MLLHTITGLHPDETsERGLPLKFIDKYIFPGGELPSISMIVESS-SEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEA 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 754493224  368 EKLgFDERFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:pfam02353 240 IAL-QSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
56-401 8.56e-90

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 276.34  E-value: 8.56e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  56 DVQILTPGVYWRVLTGGSLAAAEAWMDGEWETAQLTPLLQILaLNGEVLGRLENGFRLLgrpLERLRH-WTRRNSRAQAR 134
Cdd:PRK11705  38 DIQVHNPRFFKRVLQEGSLGLGESYMDGWWDCDRLDEFFSRV-LRAGLDEKLPHHLKDT---LRILRArLFNLQSKKRAW 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 135 ENIAAHYDLGNAFYAHFLDKELLYSSALFtADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYGCR 214
Cdd:PRK11705 114 IVGKEHYDLGNDLFEAMLDPRMQYSCGYW-KDADTLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 215 VTTTTLSQEQYIWATERiaRAGLQdrVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQAI 294
Cdd:PRK11705 193 VVGVTISAEQQKLAQER--CAGLP--VEIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 295 TiqdqRYRDYSKSVDFIQRYIFPGGFLPSITAMNELMTRHtdFVVRNLFDMGPDYARTLAHWRQRFVHAWQEIEKlGFDE 374
Cdd:PRK11705 269 G----SNKTDTNVDPWINKYIFPNGCLPSVRQIAQASEGL--FVMEDWHNFGADYDRTLMAWHENFEAAWPELAD-NYSE 341

                        330       340
                 ....*....|....*....|....*..
gi 754493224 375 RFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:PRK11705 342 RFYRMWRYYLLSCAGAFRARDIQLWQV 368
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 139-293 2.53e-73

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 225.96  E-value: 2.53e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 139 AHYDLGNAFYAHFLDKELLYSSALFTADEQDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYGCRVTTT 218
Cdd:COG2230    1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754493224 219 TLSQEQYIWATERIARAGLQDRVEVLLCDYRDL--TGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQA 293
Cdd:COG2230   81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 194-287 3.18e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 70.67  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  194 LEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYIWATERIARAGLqdRVEVLLCDYRDL---TGQYDKLVSIEMIEAVGQR 270
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLpfpDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 754493224  271 YLPTFFRTCQARLRPGG 287
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 169-291 2.91e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 66.56  E-value: 2.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 169 DLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHyGCRVTTTTLSQEQYIWATERIARAGLqdRVEVLLCDY 248
Cdd:COG2226    2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGL--NVEFVVGDA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 754493224 249 RDL---TGQYDKLVSIEMIEAVgqRYLPTFFRTCQARLRPGGRMAI 291
Cdd:COG2226   79 EDLpfpDGSFDLVISSFVLHHL--PDPERALAEIARVLKPGGRLVV 122
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 176-291 5.58e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 59.65  E-value: 5.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 176 AKMARLCEQLALNPGdHLLEIGTGWGAMAEYAARHyGCRVTTTTLSQEQYIWATERIARAglqdRVEVLLCDYRDL---T 252
Cdd:COG2227   12 RRLAALLARLLPAGG-RVLDVGCGTGRLALALARR-GADVTGVDISPEALEIARERAAEL----NVDFVQGDLEDLpleD 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 754493224 253 GQYDKLVSIEMIEAVgqRYLPTFFRTCQARLRPGGRMAI 291
Cdd:COG2227   86 GSFDLVICSEVLEHL--PDPAALLRELARLLKPGGLLLL 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 193-292 2.20e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.44  E-value: 2.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 193 LLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQyIWATERIARAGLQDRVEVLLCDYRDLT----GQYDKLVSIEMIEAVG 268
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVA-LELARKAAAALLADNVEVLKGDAEELPpeadESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 754493224 269 QRYLPtFFRTCQARLRPGGRMAIQ 292
Cdd:cd02440   81 EDLAR-FLEEARRLLKPGGVLVLT 103
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 178-302 2.39e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.85  E-value: 2.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 178 MARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYIWATERIARAGLqDRVEVLLCDYRDL----TG 253
Cdd:COG0500   15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdplpAE 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 754493224 254 QYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQAITIQDQRYR 302
Cdd:COG0500   94 SFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSL 142
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 179-287 1.18e-08

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 54.03  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 179 ARLCEQLA-LNPGDHLLEIGTGWG----AMAEYAARhyGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRD--- 250
Cdd:COG4122    5 GRLLYLLArLLGAKRILEIGTGTGystlWLARALPD--DGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEvlp 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 754493224 251 --LTGQYDkLVsieMIEAVGQRYlPTFFRTCQARLRPGG 287
Cdd:COG4122   83 rlADGPFD-LV---FIDADKSNY-PDYLELALPLLRPGG 116
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 194-291 4.05e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.74  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  194 LEIGTGWGAMAEYAARhYGCRVTTTTLSQEQYIWATERIARAGLQDRVevllCDYRDLT---GQYDKLVSIEMIEAVgqR 270
Cdd:pfam08241   1 LDVGCGTGLLTELLAR-LGARVTGVDISPEMLELAREKAPREGLTFVV----GDAEDLPfpdNSFDLVLSSEVLHHV--E 73

                          90       100
                  ....*....|....*....|.
gi 754493224  271 YLPTFFRTCQARLRPGGRMAI 291
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
189-292 6.50e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.21  E-value: 6.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 189 PGDHLLEIGTGWGAMAEY-AARHYGCRVTTTTLSQEqyiwATERiARAGLqDRVEVLLCDYRDLT--GQYDKLVSIEMIE 265
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALlAERFPGARVTGVDLSPE----MLAR-ARARL-PNVRFVVADLRDLDppEPFDLVVSNAALH 74

                         90       100
                 ....*....|....*....|....*..
gi 754493224 266 AVGQRylPTFFRTCQARLRPGGRMAIQ 292
Cdd:COG4106   75 WLPDH--AALLARLAAALAPGGVLAVQ 99
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
188-296 3.78e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 50.81  E-value: 3.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 188 NPGDHLLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDLT--GQYDKLVSiEMIE 265
Cdd:COG4076   34 KPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDlpEKADVIIS-EMLD 112

                         90       100       110
                 ....*....|....*....|....*....|...
gi 754493224 266 --AVGQRYLPTFFRTCQARLRPGGRMAIQAITI 296
Cdd:COG4076  113 taLLDEGQVPILNHARKRLLKPGGRIIPERITN 145
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 178-291 1.42e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 48.55  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 178 MARLCEQLALNPGDHLLEIGTGWGAMAEYAARHyGCRVTTTTLSQEQYIWATERIARAGLqDRVEVLlcdYRDLT----- 252
Cdd:COG2518   55 VARMLEALDLKPGDRVLEIGTGSGYQAAVLARL-AGRVYSVERDPELAERARERLAALGY-DNVTVR---VGDGAlgwpe 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 754493224 253 -GQYDKLVsiemIEAVGQRYLPTFFrtcqARLRPGGRMAI 291
Cdd:COG2518  130 hAPFDRII----VTAAAPEVPEALL----EQLAPGGRLVA 161
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
132-305 3.97e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.83  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 132 QARENIAAHYDLGNAFYAHFLDKELLYssalftadeqdltAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHY 211
Cdd:COG4976    2 ALDAYVEALFDQYADSYDAALVEDLGY-------------EAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 212 GcRVTTTTLSQEqyiwATERIARAGLQDRVEVL-LCDYRDLTGQYDKLVSIEMIEAVGQryLPTFFRTCQARLRPGGRMA 290
Cdd:COG4976   69 Y-RLTGVDLSEE----MLAKAREKGVYDRLLVAdLADLAEPDGRFDLIVAADVLTYLGD--LAAVFAGVARALKPGGLFI 141

                        170
                 ....*....|....*
gi 754493224 291 IQAITIQDQRYRDYS 305
Cdd:COG4976  142 FSVEDADGSGRYAHS 156
PLN02244 PLN02244
tocopherol O-methyltransferase
 194-291 6.37e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 44.74  E-value: 6.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 194 LEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDL---TGQYDKLVSIEMIEAV--G 268
Cdd:PLN02244 123 VDVGCGIGGSSRYLARKYGANVKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQpfeDGQFDLVWSMESGEHMpdK 202

                         90       100
                 ....*....|....*....|...
gi 754493224 269 QRYLPTFFRTCqarlRPGGRMAI 291
Cdd:PLN02244 203 RKFVQELARVA----APGGRIII 221
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 194-288 9.19e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.20  E-value: 9.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  194 LEIGTGWGAMAEYAARHY-GCRVTTTTLSQEQYIWATERIARAGLQD--RVEVLLCDYRDLTG-QYDKLVSIEMIEAVgq 269
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERLAALGLLNavRVELFQLDLGELDPgSFDVVVASNVLHHL-- 78

                          90
                  ....*....|....*....
gi 754493224  270 RYLPTFFRTCQARLRPGGR 288
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGV 97
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 187-291 1.30e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 43.21  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 187 LNPGDHLLEIGTGWGAMAEY-AARHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDL-----TGQYDKLVS 260
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALMlAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFaaelpPGSFDLVVS 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 754493224 261 IE--MIEAVGQ----------RY-----LPTFFRTCQARLRPGGRMAI 291
Cdd:COG4123  115 NPpyFKAGSGRkspdearaiaRHedaltLEDLIRAAARLLKPGGRFAL 162
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
168-249 1.53e-04

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 42.74  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  168 QDLTAAQQAKMARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYG--CRVTTTTLSQEQYIWATERIARAGLqDRVEVLL 245
Cdd:pfam01135  52 YGQTISAPHMHAMMLELLELKPGMRVLEIGSGSGYLTACFARMVGevGRVVSIEHIPELVEIARRNLEKLGL-ENVIVVV 130


                  ....
gi 754493224  246 CDYR 249
Cdd:pfam01135 131 GDGR 134
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 181-289 1.32e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.40  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 181 LCEQLALNPGDHLLEIGTGWGAMAEYAARHY-GCRVTTTTLSqEQYIWATER-IARAGLQDrVEVLLCDYRD--LTGQYD 256
Cdd:COG2813   41 LLEHLPEPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVN-ARAVELARAnAAANGLEN-VEVLWSDGLSgvPDGSFD 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 754493224 257 KLVS-------IEMIEAVGQRylptFFRTCQARLRPGGRM 289
Cdd:COG2813  119 LILSnppfhagRAVDKEVAHA----LIADAARHLRPGGEL 154
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 179-291 1.63e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 39.61  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 179 ARLCEQLALNPGDHLLEIGTGWGamaeyaarhYGCRVTTTTLSQEQYIWATERI------ARAGLQ----DRVEVLLCD- 247
Cdd:PRK13942  66 AIMCELLDLKEGMKVLEIGTGSG---------YHAAVVAEIVGKSGKVVTIERIpelaekAKKTLKklgyDNVEVIVGDg 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 754493224 248 ---YRDLTgQYDKLVsiemIEAVGQRYLPTFFRtcqaRLRPGGRMAI 291
Cdd:PRK13942 137 tlgYEENA-PYDRIY----VTAAGPDIPKPLIE----QLKDGGIMVI 174
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 175-292 2.25e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.56  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  175 QAKMARLCEQLALNPGDH--LLEIGTGWGAMAEYaARHYGCRVTTTtlsqEQYIWATERIARAGLQDRVEVLLCDYrdLT 252
Cdd:pfam13489   6 ERLLADLLLRLLPKLPSPgrVLDFGCGTGIFLRL-LRAQGFSVTGV----DPSPIAIERALLNVRFDQFDEQEAAV--PA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 754493224  253 GQYDKLVSIEMIEAVgqRYLPTFFRTCQARLRPGGRMAIQ 292
Cdd:pfam13489  79 GKFDVIVAREVLEHV--PDPPALLRQIAALLKPGGLLLLS 116
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 181-293 2.33e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.73  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224  181 LCEQLALNPGDHLLEIGTGWGAMAEYAARHYGcrVTTTTLSQEQY--IWATERIARAGLQDRVEVLLCD-YRDLT-GQYD 256
Cdd:pfam05175  23 LLEHLPKDLSGKVLDLGCGAGVLGAALAKESP--DAELTMVDINAraLESARENLAANGLENGEVVASDvYSGVEdGKFD 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 754493224  257 KLVS-------IEMIEAVGQRylptFFRTCQARLRPGGRMAIQA 293
Cdd:pfam05175 101 LIISnppfhagLATTYNVAQR----FIADAKRHLRPGGELWIVA 140
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 189-291 2.77e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 38.99  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 189 PGDHLLEIGTGWGAMAEYAARH---YGcRVTTTTLSQEQYIWATERIARAGLQDRVEVLLCDYRDLT--GQYDKLVsIEM 263
Cdd:COG2519   91 PGARVLEAGTGSGALTLALARAvgpEG-KVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIdeGDVDAVF-LDM 168

                         90       100
                 ....*....|....*....|....*...
gi 754493224 264 IEAVgqRYLPtffrTCQARLRPGGRMAI 291
Cdd:COG2519  169 PDPW--EALE----AVAKALKPGGVLVA 190
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
192-289 3.56e-03

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 38.55  E-value: 3.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224   192 HLLEIGTGWGA-MAEYAARHYGCRVTTTTLSQEQYIWATERIARAGLQDRVEVLlcdYRDLT-----GQYDKLVSIEMIE 265
Cdd:smart00828   2 RVLDFGCGYGSdLIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIF---YRDSAkdpfpDTYDLVFGFEVIH 78

                           90       100
                   ....*....|....*....|....
gi 754493224   266 AVGQRYLptFFRTCQARLRPGGRM 289
Cdd:smart00828  79 HIKDKMD--LFSNISRHLKDGGHL 100
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
192-294 5.33e-03

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 37.89  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493224 192 HLLEIGTGWGAMAEYAARHYG-CRVTT-------TTLSQEQYiwateRIARAGLQD-RVEVLLCD---Y-RDLTGQYDkL 258
Cdd:COG0421   40 RVLIIGGGDGGLARELLKHPPvERVDVveidpevVELAREYF-----PLLAPAFDDpRLRVVIGDgraFlREAEESYD-V 113

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 754493224 259 VSIEMIEAVG---QRYLPTFFRTCQARLRPGGRMAIQAI 294
Cdd:COG0421  114 IIVDLTDPVGpaeGLFTREFYEDCRRALKPGGVLVVNLG 152
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 178-243 8.16e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 37.48  E-value: 8.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754493224 178 MARLCEQLALNPGDHLLEIGTGWGAMAEYAARHYGC--RVTTTTLSQEQYIWATERIARAGLQDRVEV 243
Cdd:PRK13944  61 VAMMCELIEPRPGMKILEVGTGSGYQAAVCAEAIERrgKVYTVEIVKELAIYAAQNIERLGYWGVVEV 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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