|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
1-215 |
3.05e-128 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 360.60 E-value: 3.05e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 1 MRQLITPENTMKKTSFTKHRVERFSSRQAARRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIPVQGVYAAGRLDR 80
Cdd:PRK11394 1 MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 81 DSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRER 160
Cdd:PRK11394 81 DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 754493592 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGRYTLDTLANGEWRDA 215
Cdd:PRK11394 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREA 215
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
41-207 |
2.85e-102 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 292.75 E-value: 2.85e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 41 VILFNKPYDVLPQFTDEA-GRSTLKDYIPVQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDE 119
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYIDDPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVPTE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 120 ETLAKLRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
Cdd:cd02566 81 DALEQLRNGVELGDGLTLPAKVEKVDEPPWLWEREPPIRFRKNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRVSI 160
|
....*...
gi 754493592 200 GRYTLDTL 207
Cdd:cd02566 161 GDIGLDNL 168
|
|
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
31-213 |
1.31e-59 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 186.78 E-value: 1.31e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 31 RRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIP---VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGK 107
Cdd:COG1187 54 KPLKLPEEPVYLLLNKPAGVVSTTKDPEGRPTVFDLLPearKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 108 IYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNepewlwprnppirerkSIPTSWLKITLYEGRNRQVRRMTAHV 187
Cdd:COG1187 134 EYLVRVDGPVTEEDLERLREGVELEDGPTKPAKVEILS----------------GEANTWLRITLTEGRNRQVRRMFEAV 197
|
170 180
....*....|....*....|....*.
gi 754493592 188 GFPTLRLIRYAMGRYTLDTLANGEWR 213
Cdd:COG1187 198 GLPVVRLKRVRIGPLTLGDLPPGEWR 223
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
75-214 |
1.74e-59 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 182.91 E-value: 1.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 75 AGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEPEWlwprn 154
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEPGF----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 155 ppirerksiPTsWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGRYTLDTLANGEWRD 214
Cdd:TIGR00093 76 ---------PT-WLRVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRP 125
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
41-186 |
1.09e-18 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 78.99 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 41 VILFNKPYDVLPQFTD-EAGRSTLKDYIPVQG-----VYAAGRLDRDSEGLLVLTNDGALQAKLTQ--PGKRSGKIYFVQ 112
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDsLTKLLSLLALLLRRElgvkrLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754493592 113 VEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEPEWLWprnPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
Cdd:pfam00849 81 VDKPEEEEGTIKSPIKKEKNKSPFRKEEELGGKKAVTHL---KVLKSGSKGDYSLLELELVTGRKHQIRAHLAA 151
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
1-215 |
3.05e-128 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 360.60 E-value: 3.05e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 1 MRQLITPENTMKKTSFTKHRVERFSSRQAARRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIPVQGVYAAGRLDR 80
Cdd:PRK11394 1 MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 81 DSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRER 160
Cdd:PRK11394 81 DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 754493592 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGRYTLDTLANGEWRDA 215
Cdd:PRK11394 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREA 215
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
41-207 |
2.85e-102 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 292.75 E-value: 2.85e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 41 VILFNKPYDVLPQFTDEA-GRSTLKDYIPVQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDE 119
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYIDDPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVPTE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 120 ETLAKLRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
Cdd:cd02566 81 DALEQLRNGVELGDGLTLPAKVEKVDEPPWLWEREPPIRFRKNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRVSI 160
|
....*...
gi 754493592 200 GRYTLDTL 207
Cdd:cd02566 161 GDIGLDNL 168
|
|
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
31-213 |
1.31e-59 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 186.78 E-value: 1.31e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 31 RRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIP---VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGK 107
Cdd:COG1187 54 KPLKLPEEPVYLLLNKPAGVVSTTKDPEGRPTVFDLLPearKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 108 IYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNepewlwprnppirerkSIPTSWLKITLYEGRNRQVRRMTAHV 187
Cdd:COG1187 134 EYLVRVDGPVTEEDLERLREGVELEDGPTKPAKVEILS----------------GEANTWLRITLTEGRNRQVRRMFEAV 197
|
170 180
....*....|....*....|....*.
gi 754493592 188 GFPTLRLIRYAMGRYTLDTLANGEWR 213
Cdd:COG1187 198 GLPVVRLKRVRIGPLTLGDLPPGEWR 223
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
75-214 |
1.74e-59 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 182.91 E-value: 1.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 75 AGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEPEWlwprn 154
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEPGF----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 155 ppirerksiPTsWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGRYTLDTLANGEWRD 214
Cdd:TIGR00093 76 ---------PT-WLRVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRP 125
|
|
| PseudoU_synth_RsuA_like |
cd02870 |
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the ... |
41-198 |
1.89e-51 |
|
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this family are bacterial proteins.
Pssm-ID: 211347 [Multi-domain] Cd Length: 146 Bit Score: 163.05 E-value: 1.89e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 41 VILFNKPYDVLPQFTDEAGRSTLKDYIP--VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPD 118
Cdd:cd02870 1 YLLLNKPRGVVSTVRDPEGRPTVLDLLKdvGERLFPVGRLDYDTEGLLLLTNDGELANRLTHPRYGVEKTYLVKVRGVPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 119 EETLAKLRSGVTLNDGPTLPAGIERVNEPEwlwprnppirerksiPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYA 198
Cdd:cd02870 81 EEELRRLRAGVELDDGKTAPAKVKVLSRDP---------------KNTLLEVTLHEGRNRQVRRMFEAVGHPVLRLKRVR 145
|
|
| PseudoU_synth_RsuA |
cd02553 |
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and ... |
40-213 |
1.52e-42 |
|
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.
Pssm-ID: 211327 [Multi-domain] Cd Length: 167 Bit Score: 141.12 E-value: 1.52e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 40 RVILFNKPYDVLPQFTDEAGRSTLkDYIPVQ----GVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEG 115
Cdd:cd02553 1 VYLMLNKPAGVVCATKDPHHPTVI-DLLPEPdrrrDLFPVGRLDKDTTGLLLLTNDGQLAHRLTSPKKHVPKTYEVTLAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 116 EPDEETLAKLRSGVTLNDG-PTLPAGIERVNEpewlwprnppirerksiptSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
Cdd:cd02553 80 PLTEDDIEAFAEGVLLHDGyPTKPAKLEILSP-------------------TTVRLTITEGKYHQVKRMFAAVGNKVVAL 140
|
170 180
....*....|....*....|
gi 754493592 195 IRYAMGRYTLD-TLANGEWR 213
Cdd:cd02553 141 HRIRIGGLELDdDLAPGEWR 160
|
|
| PseudoU_synth_Rsu_Rlu_like |
cd02550 |
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and ... |
41-196 |
6.94e-35 |
|
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.
Pssm-ID: 211325 [Multi-domain] Cd Length: 154 Bit Score: 121.33 E-value: 6.94e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 41 VILFNKPYDVLPQFTDEAGRSTLKDYIPVQG---VYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEP 117
Cdd:cd02550 1 ILVLNKPSGLVCHPTDRDRDPTVVVRLDKLHgprVHAAGRLDKDTSGLLLLTNDGRLQRRLTEPRREIEKEYLVTVRGEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 118 DEETLAKL-------RSGVTLNDGPTLPAGIERVNEPEwlwprnppirerksiPTSWLKITLYEGRNRQVRRMTAHVGFP 190
Cdd:cd02550 81 DEEGIEDLatvrrgrLSGLVDEGVPLAVTKVRVIGEHG---------------GTGRLRLTLKTGRTHQIRRHCAAVGFP 145
|
....*.
gi 754493592 191 TLRLIR 196
Cdd:cd02550 146 VLRLHR 151
|
|
| PseudoU_synth_RluB |
cd02556 |
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and ... |
40-213 |
4.87e-34 |
|
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluB makes psi2605 in 23S RNA. psi2605 has been detected in eubacteria but, not in eukarya and archea despite the presence of a precursor U at that site.
Pssm-ID: 211330 [Multi-domain] Cd Length: 167 Bit Score: 119.34 E-value: 4.87e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 40 RVILFNKPYDVLPQFTDEAGRSTLKDYIPVQG---VYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGE 116
Cdd:cd02556 1 RVLIYHKPEGLICTRKDPKGRPTVFDLLPKLGiprWISVGRLDLNTEGLLLFTNDGELANRLMHPSNEIEREYAVRVFGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 117 PDEETLAKLRSGVTLNDGPTLPagIERVNEpewlwprnppiRERKSipTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
Cdd:cd02556 81 VTDEQLKSLKKGVELEDGFAGF--KSIQLE-----------GGEGK--NSWYRVTLREGRNREVRRLWEAFGLQVSRLIR 145
|
170
....*....|....*...
gi 754493592 197 YAMGRYTL-DTLANGEWR 213
Cdd:cd02556 146 IRYGPIFLpGNLKRGQWE 163
|
|
| PseudoU_synth_RluF |
cd02554 |
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial ... |
42-214 |
3.07e-29 |
|
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluF makes psi2604 in 23S RNA. psi2604 has only been detected in E. coli. It is absent from other eubacteria despite a precursor U at that site and from eukarya and archea which lack a precursor U at that site.
Pssm-ID: 211328 [Multi-domain] Cd Length: 164 Bit Score: 107.01 E-value: 3.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 42 ILFNKPYDVLPQfTDEAGRSTLKDYI-PVQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDEE 120
Cdd:cd02554 3 IAYNKPVGIDCT-LERADEDNIIDFVnPPPRIFPIGRLDKDSEGLILLTNDGDLVNKILHADNNHEKEYLVTVNKPITDE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 121 TLAKLRSGVTLNDGPTLPAGIERVNEpewlwprnppirerksiptSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 200
Cdd:cd02554 82 FIEGMSNGVVILGTVTKPCKVERLAK-------------------DKFRIVLTQGLNRQIRRMCEALGYRVTDLKRVRIM 142
|
170
....*....|....
gi 754493592 201 RYTLDTLANGEWRD 214
Cdd:cd02554 143 NIELGDLAPGEWRP 156
|
|
| PRK10700 |
PRK10700 |
23S rRNA pseudouridine(2605) synthase RluB; |
23-212 |
1.98e-20 |
|
23S rRNA pseudouridine(2605) synthase RluB;
Pssm-ID: 182659 [Multi-domain] Cd Length: 289 Bit Score: 86.74 E-value: 1.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 23 RFSSRQAARRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIP-VQGV--YAAGRLDRDSEGLLVLTNDGALQAKLT 99
Cdd:PRK10700 51 RIDGHLISVKESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPkLRGArwIAVGRLDVNTCGLLLFTTDGELANRLM 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 100 QPGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGP----TLP-AGIERVNEpewlwprnppirerksiptsWLKITLYE 174
Cdd:PRK10700 131 HPSREVEREYAVRVFGQVDDAKLRQLSRGVQLEDGPaafkTIKfSGGEGINQ--------------------WYNVTLTE 190
|
170 180 190
....*....|....*....|....*....|....*....
gi 754493592 175 GRNRQVRRMTAHVGFPTLRLIRYAMGRYTLDT-LANGEW 212
Cdd:PRK10700 191 GRNREVRRLWEAVGVQVSRLIRVRYGDIPLPKgLPRGGW 229
|
|
| PSSA_1 |
cd02555 |
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial ... |
74-213 |
3.82e-20 |
|
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. The TruA family is comprised of proteins related to Escherichia coli RsuA.
Pssm-ID: 211329 [Multi-domain] Cd Length: 177 Bit Score: 83.61 E-value: 3.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 74 AAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEpewlwpr 153
Cdd:cd02555 49 PIGPLDKDASGLLVFSQDGRVLRKLIGDASRLEQEYLVEVRGELTAGGLERLNHGLTYDGRELPPAKVSWQNE------- 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 154 nppirerksiptSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGRYTLDTLANGEWR 213
Cdd:cd02555 122 ------------QRLRFALKEPQPGQIRRMCESVGLEVVALRRIRIGRVSLGKLPLGQWR 169
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
41-186 |
1.09e-18 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 78.99 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 41 VILFNKPYDVLPQFTD-EAGRSTLKDYIPVQG-----VYAAGRLDRDSEGLLVLTNDGALQAKLTQ--PGKRSGKIYFVQ 112
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDsLTKLLSLLALLLRRElgvkrLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754493592 113 VEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEPEWLWprnPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
Cdd:pfam00849 81 VDKPEEEEGTIKSPIKKEKNKSPFRKEEELGGKKAVTHL---KVLKSGSKGDYSLLELELVTGRKHQIRAHLAA 151
|
|
| PRK10475 |
PRK10475 |
23S rRNA pseudouridine(2604) synthase RluF; |
33-214 |
1.13e-18 |
|
23S rRNA pseudouridine(2604) synthase RluF;
Pssm-ID: 236698 [Multi-domain] Cd Length: 290 Bit Score: 82.09 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 33 PQETQPKRVILFNKPYDVLPQfTDEAGRSTLKDYIP-VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYFV 111
Cdd:PRK10475 61 PREAEDLVLIALNKPVGIVST-TEDGERDNIVDFVNhSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 112 QVEGEPDEETLAKLRSGVtlndgPTLPAGIERVnepewlwprnppiRERKSIPTSWlKITLYEGRNRQVRRMTAHVGFPT 191
Cdd:PRK10475 140 TVDKPITDEFIRGMGAGV-----PILGTVTKKC-------------KVKKEAPFVF-RITLVQGLNRQIRRMCEHFGYEV 200
|
170 180
....*....|....*....|...
gi 754493592 192 LRLIRYAMGRYTLDTLANGEWRD 214
Cdd:PRK10475 201 TKLERTRIMNVSLSGIPLGEWRD 223
|
|
| PRK10839 |
PRK10839 |
16S rRNA pseudouridine(516) synthase RsuA; |
34-213 |
1.05e-16 |
|
16S rRNA pseudouridine(516) synthase RsuA;
Pssm-ID: 236774 [Multi-domain] Cd Length: 232 Bit Score: 75.53 E-value: 1.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 34 QETQPkRVILFNKPYDVLPQfTDEAGRSTLKDYI--PV-QGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRSGKIYF 110
Cdd:PRK10839 56 QQHGP-RYFMLNKPQGYVCS-TDDPDHPTVLYFLdePVaYKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 111 VQVEGEPDEETLAKLRSGVTLNDGPTL--PAGIERVNEPEwlwprnppirerksiptswLKITLYEGRNRQVRRMTAHVG 188
Cdd:PRK10839 134 VTLESPVADDTAEQFAKGVQLHNEKDLtkPAVLEVITPTQ-------------------VRLTISEGRYHQVKRMFAAVG 194
|
170 180
....*....|....*....|....*.
gi 754493592 189 FPTLRLIRYAMGRYTLD-TLANGEWR 213
Cdd:PRK10839 195 NHVVELHRERIGAITLDaDLAPGEYR 220
|
|
| PseudoU_synth_TruC |
cd02563 |
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific ... |
70-201 |
3.60e-04 |
|
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not universally conserved.
Pssm-ID: 211333 [Multi-domain] Cd Length: 223 Bit Score: 40.40 E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754493592 70 QGVYAAGRLDRDSEGLLVLTNDGALQAKLTQ--PGKRSGKIYFVQVEGEPDEETLAKLRSGVTLNDGPTLPAGIERVNEP 147
Cdd:cd02563 44 QHVYPVHRLDRPTSGVLLFALSSEVARKLGEqfTEHRVHKTYLAVVRGYVPESGTIDYPLSEELDKLADKFASDDKAPQA 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 754493592 148 EWLWPR-----NPPIRERKsIPT---SWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGR 201
Cdd:cd02563 124 ATTHYRllaveELPVVVGK-YPTsrySLVELTPHTGRKHQLRRHLAHIRHPIIGDTTHGDGR 184
|
|
| |
