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Conserved domains on  [gi|754494166|ref|WP_041911061|]
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MULTISPECIES: multidrug efflux RND transporter permease subunit [Enterobacter]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 11487668)

efflux RND (Resistance-Nodulation-Cell Division) transporter permease subunit similar to the multidrug efflux pump subunit AcrB, which is a component of AcrA-AcrB-AcrZ-TolC drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
1-1048 0e+00

multidrug efflux RND transporter permease subunit AcrB;


:

Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 2134.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:PRK15127    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:PRK15127   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:PRK15127  161 NMKDPISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:PRK15127  241 TSTEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:PRK15127  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:PRK15127  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  481 SVLVALILTPALCATMLKPVQKGGHGEHK-GFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:PRK15127  481 SVLVALILTPALCATMLKPIAKGDHGEGKkGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVRLP 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:PRK15127  561 SSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  640 ENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPDLLVGVRPNG 719
Cdd:PRK15127  641 ENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKHPDMLVGVRPNG 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:PRK15127  721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVP 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAIS 879
Cdd:PRK15127  801 FSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASKLPTGVGYDWTGMSYQERLSGNQAPALYAIS 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  880 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGL 959
Cdd:PRK15127  881 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  960 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAIFFVPVFFVVVRRRFSRKNEDV 1039
Cdd:PRK15127  961 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDI 1040

                  ....*....
gi 754494166 1040 EHSHSVEPH 1048
Cdd:PRK15127 1041 EHSHTVDHH 1049
 
Name Accession Description Interval E-value
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
1-1048 0e+00

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 2134.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:PRK15127    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:PRK15127   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:PRK15127  161 NMKDPISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:PRK15127  241 TSTEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:PRK15127  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:PRK15127  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  481 SVLVALILTPALCATMLKPVQKGGHGEHK-GFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:PRK15127  481 SVLVALILTPALCATMLKPIAKGDHGEGKkGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVRLP 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:PRK15127  561 SSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  640 ENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPDLLVGVRPNG 719
Cdd:PRK15127  641 ENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKHPDMLVGVRPNG 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:PRK15127  721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVP 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAIS 879
Cdd:PRK15127  801 FSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASKLPTGVGYDWTGMSYQERLSGNQAPALYAIS 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  880 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGL 959
Cdd:PRK15127  881 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  960 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAIFFVPVFFVVVRRRFSRKNEDV 1039
Cdd:PRK15127  961 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDI 1040

                  ....*....
gi 754494166 1040 EHSHSVEPH 1048
Cdd:PRK15127 1041 EHSHTVDHH 1049
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
1-1045 0e+00

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 1902.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166     1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:TIGR00915    1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:TIGR00915   81 SSDSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:TIGR00915  161 NMVDPLSRLEGVGDVQLFGSQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPGQQLNATIIAQTRL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:TIGR00915  241 QTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:TIGR00915  321 MKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:TIGR00915  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   481 SVLVALILTPALCATMLKPVQKGGHGEHK-GFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:TIGR00915  481 SVLVALILTPALCATMLKPIEKGEHHEKKgGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRLP 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:TIGR00915  561 TSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKANVESVFTVNGFSFAGRGQNMGMAFIRLKDWEERTGK 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   640 ENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPDlLVGVRPNG 719
Cdd:TIGR00915  641 ENSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPA-LTRVRPNG 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:TIGR00915  720 LEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVP 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAIS 879
Cdd:TIGR00915  800 FSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQKLPPGFGFSWTGMSYEERLSGSQAPALYALS 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   880 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKeGKGL 959
Cdd:TIGR00915  880 LLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQ-GKSI 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   960 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAIFFVPVFFVVVRRRFSRKNEDV 1039
Cdd:TIGR00915  959 VEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRRLFKRKAHEK 1038

                   ....*.
gi 754494166  1040 EHSHSV 1045
Cdd:TIGR00915 1039 EMSVEH 1044
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
1-1018 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1482.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166     1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    81 NSdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:pfam00873   81 QS-SYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   161 NMKDAISRTSGVGDVQLFG-SQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLggtppvKGQQLNASIIAQTR 239
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGgSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQL------EGQGLQALIRAQGQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   240 LTSADEFSKILLKvNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPS 319
Cdd:pfam00873  234 LQSAEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQ 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMV 399
Cdd:pfam00873  313 GVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLV 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   400 LAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479
Cdd:pfam00873  393 LAIGLVVDDAIVVVENIERVLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAIL 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   480 LSVLVALILTPALCATMLKPVQKGGHGehkGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:pfam00873  473 LSVLVALTLTPALCATLLKPRREPKHG---GFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIP 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYltKEKANVESVFAVNGFGFAG--RGQNTGIAFVSLKDWADRP 637
Cdd:pfam00873  550 TEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKIL--KEKPEVESVFAVTGFAFSGdnNGPNSGDAFISLKPWKERP 627
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   638 GDENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLID-QGGLGHEKLTQARNQLFGEVAKHPDlLVGVR 716
Cdd:pfam00873  628 GPEKSVQALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVkIFGDDLDALDEARNQILAALAQLPG-LSDVR 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   717 PNGLEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQ 796
Cdd:pfam00873  707 SDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGK 786
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   797 MVPFSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASK--LPAGIGYDWTGMSYQERLSGNQAPA 874
Cdd:pfam00873  787 MIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQvkLPPGYGYTWTGQFEQEQLAGNSLPI 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   875 LYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEK 954
Cdd:pfam00873  867 LIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQ 946
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754494166   955 EGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:pfam00873  947 EGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTL 1010
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1018 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1255.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:COG0841     3 LSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVinTNGTMTQEDISDYVGA 160
Cdd:COG0841    83 TS-SEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLAL--SSDDLDELELSDYAER 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGS-QYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGtppvkgQQLNASIIAQTR 239
Cdd:COG0841   160 NIKDRLERVPGVGQVQIFGGrEREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGG------GDREYTVRTNGR 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  240 LTSADEFSKILLKVNqDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPS 319
Cdd:COG0841   234 LKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPE 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMV 399
Cdd:COG0841   313 GVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALV 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  400 LAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479
Cdd:COG0841   393 LAIGIVVDDAIVVVENIERHM-EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALL 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  480 LSVLVALILTPALCATMLKPvqkGGHGEHKGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:COG0841   472 ISLFVALTLTPALCARLLKP---HPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLP 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLtkEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:COG0841   549 TEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILL--EVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRS 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  640 enkVEAITGRAMGTFSQIKDAMVFAFNLPAIvELGTATGFDFQLIdqgGLGHEKLTQARNQLFGEVAKHPdLLVGVRPNG 719
Cdd:COG0841   627 ---ADEIIARLREKLAKIPGARVFVFQPPAG-GLGSGAPIEVQLQ---GDDLEELAAAAEKLLAALRQIP-GLVDVRSDL 698
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:COG0841   699 QLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVP 778
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASK--LPAGIGYDWTGMSYQERLSGNQAPALYA 877
Cdd:COG0841   779 LSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAElkLPPGVSIEFTGQAEEEQESFSSLGLAFL 858
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  878 ISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEkEGK 957
Cdd:COG0841   859 LALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLRE-EGM 937
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754494166  958 GLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:COG0841   938 SLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTL 998
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
5-1016 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 778.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdS 84
Cdd:NF033617    4 FIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQS-S 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   85 TGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVE-KSSSSFLMVVGVinTNGTMTQEDISDYVGANMK 163
Cdd:NF033617   83 LGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKaNSADTPIMYIGL--TSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  164 DAISRTSGVGDVQLFGSQY-AMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQlggtppVKGQQLNASIIAQTRLTS 242
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRpAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGA------VRGDSVVSTVRANDQLKT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  243 ADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSGLK 322
Cdd:NF033617  235 AEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  323 IVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAI 402
Cdd:NF033617  315 VNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAI 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  403 GLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSV 482
Cdd:NF033617  395 GLVVDDAIVVVENIHRHI-EEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISG 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  483 LVALILTPALCATMLKPVQKGGHGEHKgffgwFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLPSSF 562
Cdd:NF033617  474 IVALTLTPMMCSRLLKANEKPGRFARA-----VDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKEL 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  563 LPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKanVESVFAVNGFGfAGRGQNTGIAFVSLKDWADRpgdENK 642
Cdd:NF033617  549 APSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPE--VQSLTSFNGVG-GNPGDNTGFGIINLKPWDER---DVS 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  643 VEAITGRAMGTFSQIKDAMVFAFNLPAIvELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPdLLVGVRPNGLED 722
Cdd:NF033617  623 AQEIIDRLRPKLAKVPGMDLFLFPLQDL-PGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSP-QFADVDSDLQDK 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  723 TPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVPFSS 802
Cdd:NF033617  701 GPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLST 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  803 FSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMN-LMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAISLI 881
Cdd:NF033617  781 LAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEaLDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALA 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  882 VVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIE 961
Cdd:NF033617  861 AIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRRE 940
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 754494166  962 ATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVL 1016
Cdd:NF033617  941 AIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLF 995
 
Name Accession Description Interval E-value
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
1-1048 0e+00

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 2134.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:PRK15127    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:PRK15127   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:PRK15127  161 NMKDPISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:PRK15127  241 TSTEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:PRK15127  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:PRK15127  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  481 SVLVALILTPALCATMLKPVQKGGHGEHK-GFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:PRK15127  481 SVLVALILTPALCATMLKPIAKGDHGEGKkGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVRLP 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:PRK15127  561 SSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  640 ENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPDLLVGVRPNG 719
Cdd:PRK15127  641 ENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKHPDMLVGVRPNG 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:PRK15127  721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVP 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAIS 879
Cdd:PRK15127  801 FSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASKLPTGVGYDWTGMSYQERLSGNQAPALYAIS 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  880 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGL 959
Cdd:PRK15127  881 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  960 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAIFFVPVFFVVVRRRFSRKNEDV 1039
Cdd:PRK15127  961 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDI 1040

                  ....*....
gi 754494166 1040 EHSHSVEPH 1048
Cdd:PRK15127 1041 EHSHTVDHH 1049
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
1-1045 0e+00

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 1902.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166     1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:TIGR00915    1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:TIGR00915   81 SSDSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:TIGR00915  161 NMVDPLSRLEGVGDVQLFGSQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPGQQLNATIIAQTRL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:TIGR00915  241 QTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:TIGR00915  321 MKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:TIGR00915  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   481 SVLVALILTPALCATMLKPVQKGGHGEHK-GFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:TIGR00915  481 SVLVALILTPALCATMLKPIEKGEHHEKKgGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRLP 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:TIGR00915  561 TSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKANVESVFTVNGFSFAGRGQNMGMAFIRLKDWEERTGK 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   640 ENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPDlLVGVRPNG 719
Cdd:TIGR00915  641 ENSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPA-LTRVRPNG 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:TIGR00915  720 LEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVP 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAIS 879
Cdd:TIGR00915  800 FSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQKLPPGFGFSWTGMSYEERLSGSQAPALYALS 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   880 LIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKeGKGL 959
Cdd:TIGR00915  880 LLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQ-GKSI 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   960 IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAIFFVPVFFVVVRRRFSRKNEDV 1039
Cdd:TIGR00915  959 VEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRRLFKRKAHEK 1038

                   ....*.
gi 754494166  1040 EHSHSV 1045
Cdd:TIGR00915 1039 EMSVEH 1044
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
1-1018 0e+00

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 1620.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:PRK10555    1 MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:PRK10555   81 QSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVAS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:PRK10555  161 NIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:PRK10555  241 QTPEQFRDITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:PRK10555  321 LEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:PRK10555  401 AIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  481 SVLVALILTPALCATMLKPVQKGGHGEHKGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLPS 560
Cdd:PRK10555  481 SVLVAMILTPALCATLLKPLKKGEHHGQKGFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLGGMVFLFLRLPT 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  561 SFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGDE 640
Cdd:PRK10555  561 SFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKDNVMSVFATVGSGPGGNGQNVARMFIRLKDWDERDSKT 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  641 NKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPdLLVGVRPNGL 720
Cdd:PRK10555  641 GTSFAIIERATKAFNKIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAKNP-ELTRVRHNGL 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  721 EDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVPF 800
Cdd:PRK10555  720 DDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPF 799
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  801 SSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAISL 880
Cdd:PRK10555  800 SAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISL 879
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  881 IVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKeGKGLI 960
Cdd:PRK10555  880 LVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQK-GHDLF 958
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 754494166  961 EATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:PRK10555  959 EATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAI 1016
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
1-1018 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1482.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166     1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    81 NSdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:pfam00873   81 QS-SYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   161 NMKDAISRTSGVGDVQLFG-SQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLggtppvKGQQLNASIIAQTR 239
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGgSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQL------EGQGLQALIRAQGQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   240 LTSADEFSKILLKvNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPS 319
Cdd:pfam00873  234 LQSAEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQ 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMV 399
Cdd:pfam00873  313 GVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLV 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   400 LAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479
Cdd:pfam00873  393 LAIGLVVDDAIVVVENIERVLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAIL 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   480 LSVLVALILTPALCATMLKPVQKGGHGehkGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:pfam00873  473 LSVLVALTLTPALCATLLKPRREPKHG---GFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIP 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYltKEKANVESVFAVNGFGFAG--RGQNTGIAFVSLKDWADRP 637
Cdd:pfam00873  550 TEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKIL--KEKPEVESVFAVTGFAFSGdnNGPNSGDAFISLKPWKERP 627
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   638 GDENKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLID-QGGLGHEKLTQARNQLFGEVAKHPDlLVGVR 716
Cdd:pfam00873  628 GPEKSVQALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVkIFGDDLDALDEARNQILAALAQLPG-LSDVR 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   717 PNGLEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQ 796
Cdd:pfam00873  707 SDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGK 786
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   797 MVPFSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASK--LPAGIGYDWTGMSYQERLSGNQAPA 874
Cdd:pfam00873  787 MIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQvkLPPGYGYTWTGQFEQEQLAGNSLPI 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   875 LYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEK 954
Cdd:pfam00873  867 LIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQ 946
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754494166   955 EGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:pfam00873  947 EGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTL 1010
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1018 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1255.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:COG0841     3 LSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVinTNGTMTQEDISDYVGA 160
Cdd:COG0841    83 TS-SEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLAL--SSDDLDELELSDYAER 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGS-QYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGtppvkgQQLNASIIAQTR 239
Cdd:COG0841   160 NIKDRLERVPGVGQVQIFGGrEREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGG------GDREYTVRTNGR 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  240 LTSADEFSKILLKVNqDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPS 319
Cdd:COG0841   234 LKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPE 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMV 399
Cdd:COG0841   313 GVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALV 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  400 LAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479
Cdd:COG0841   393 LAIGIVVDDAIVVVENIERHM-EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALL 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  480 LSVLVALILTPALCATMLKPvqkGGHGEHKGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLP 559
Cdd:COG0841   472 ISLFVALTLTPALCARLLKP---HPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLP 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  560 SSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLtkEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGD 639
Cdd:COG0841   549 TEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILL--EVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRS 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  640 enkVEAITGRAMGTFSQIKDAMVFAFNLPAIvELGTATGFDFQLIdqgGLGHEKLTQARNQLFGEVAKHPdLLVGVRPNG 719
Cdd:COG0841   627 ---ADEIIARLREKLAKIPGARVFVFQPPAG-GLGSGAPIEVQLQ---GDDLEELAAAAEKLLAALRQIP-GLVDVRSDL 698
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  720 LEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVP 799
Cdd:COG0841   699 QLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVP 778
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  800 FSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASK--LPAGIGYDWTGMSYQERLSGNQAPALYA 877
Cdd:COG0841   779 LSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAElkLPPGVSIEFTGQAEEEQESFSSLGLAFL 858
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  878 ISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEkEGK 957
Cdd:COG0841   859 LALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLRE-EGM 937
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754494166  958 GLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:COG0841   938 SLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTL 998
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
1-1018 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 1240.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
Cdd:PRK09577    1 MARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   81 NSdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGA 160
Cdd:PRK09577   81 TS-SAGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVEKAADNIQLIVSLTSDDGRLTGVELGEYASA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  161 NMKDAISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240
Cdd:PRK09577  160 NVLQALRRVEGVGKVQFWGAEYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSAVPDSAPIAATVFADAPL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  241 TSADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSG 320
Cdd:PRK09577  240 KTPEDFGAIALRARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  321 LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVL 400
Cdd:PRK09577  320 VKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVL 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  401 AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480
Cdd:PRK09577  400 AIGILVDDAIVVVENVERLMVEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGF 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  481 SVLVALILTPALCATMLKPVQkGGHGEHKGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLPS 560
Cdd:PRK09577  480 SAFLALSLTPALCATLLKPVD-GDHHEKRGFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPT 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  561 SFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKanVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGDE 640
Cdd:PRK09577  559 AFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEP--VAYTFALGGFNLYGEGPNGGMIFVTLKDWKERKAAR 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  641 NKVEAITGRAMGTFSQIKDAMVFAFNLPAIVELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPdLLVGVRPNGL 720
Cdd:PRK09577  637 DHVQAIVARINERFAGTPNTTVFAMNSPALPDLGSTSGFDFRLQDRGGLGYAAFVAAREQLLAEGAKDP-ALTDLMFAGT 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  721 EDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVPF 800
Cdd:PRK09577  716 QDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPL 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  801 SSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAISL 880
Cdd:PRK09577  796 AAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAATLPAGIGYAWSGQSFEERLSGAQAPMLFALSV 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  881 IVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEkEGKGLI 960
Cdd:PRK09577  876 LVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVA-QRMSLA 954
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 754494166  961 EATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:PRK09577  955 DAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAV 1012
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
5-1016 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 778.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdS 84
Cdd:NF033617    4 FIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQS-S 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   85 TGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVE-KSSSSFLMVVGVinTNGTMTQEDISDYVGANMK 163
Cdd:NF033617   83 LGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKaNSADTPIMYIGL--TSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  164 DAISRTSGVGDVQLFGSQY-AMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQlggtppVKGQQLNASIIAQTRLTS 242
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRpAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGA------VRGDSVVSTVRANDQLKT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  243 ADEFSKILLKVNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSGLK 322
Cdd:NF033617  235 AEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  323 IVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAI 402
Cdd:NF033617  315 VNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAI 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  403 GLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSV 482
Cdd:NF033617  395 GLVVDDAIVVVENIHRHI-EEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISG 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  483 LVALILTPALCATMLKPVQKGGHGEHKgffgwFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLPSSF 562
Cdd:NF033617  474 IVALTLTPMMCSRLLKANEKPGRFARA-----VDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKEL 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  563 LPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYLTKEKanVESVFAVNGFGfAGRGQNTGIAFVSLKDWADRpgdENK 642
Cdd:NF033617  549 APSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPE--VQSLTSFNGVG-GNPGDNTGFGIINLKPWDER---DVS 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  643 VEAITGRAMGTFSQIKDAMVFAFNLPAIvELGTATGFDFQLIDQGGLGHEKLTQARNQLFGEVAKHPdLLVGVRPNGLED 722
Cdd:NF033617  623 AQEIIDRLRPKLAKVPGMDLFLFPLQDL-PGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSP-QFADVDSDLQDK 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  723 TPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVPFSS 802
Cdd:NF033617  701 GPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLST 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  803 FSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMN-LMEELASKLPAGIGYDWTGMSYQERLSGNQAPALYAISLI 881
Cdd:NF033617  781 LAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEaLDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALA 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  882 VVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIE 961
Cdd:NF033617  861 AIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRRE 940
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 754494166  962 ATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVL 1016
Cdd:NF033617  941 AIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLF 995
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
5-1018 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 585.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDS 84
Cdd:PRK09579    7 FIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   85 TGTVqITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVinTNGTMTQEDISDYVGANMKD 164
Cdd:PRK09579   87 NFSI-ISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISF--YSEEMSNPQITDYLSRVIQP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  165 AISRTSGVGDVQLFGSQ-YAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQlggtppVKGQQLNASIIAQTRLTSA 243
Cdd:PRK09579  164 KLATLPGMAEAEILGNQvFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGE------VKGEYVVTSINASTELKSA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  244 DEFSKILLKVNQDgSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSGLKI 323
Cdd:PRK09579  238 EAFAAIPVKTSGD-SRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKV 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  324 VYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIG 403
Cdd:PRK09579  317 SIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIG 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  404 LLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVL 483
Cdd:PRK09579  397 LVVDDAIVVVENIHRHI-EEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGI 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  484 VALILTPALCATMLKPVQKGghgehKGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLPSSFL 563
Cdd:PRK09579  476 VALTLSPMMCALLLRHEENP-----SGLAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELA 550
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  564 PDEDQGVFLTMAQLPAGASQERTQKVLDEVTDYYltKEKANVESVFAVNGFGfagrGQNTGIAFVSLKDWADRpgDENKV 643
Cdd:PRK09579  551 PEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIF--KSFPEYYSSFQINGFN----GVQSGIGGFLLKPWNER--ERTQM 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  644 EaITGRAMGTFSQIKDAMVFAFNLPAIVelGTATGFDFQLIDQGGLGHEKLTQARNQLfGEVAKHPDLLVGVRPNGLEDT 723
Cdd:PRK09579  623 E-LLPLVQAKLEEIPGLQIFGFNLPSLP--GTGEGLPFQFVINTANDYESLLQVAQRV-KQRAQESGKFAFLDIDLAFDK 698
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  724 PQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVPFSSF 803
Cdd:PRK09579  699 PEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTL 778
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  804 STSHWEYGSPRLERYNGLPSMEIlgQAAPGRSTGEAMNLMEELA-SKLPAGIGYDWTGMSYQERLSGNQAPALYAISLIV 882
Cdd:PRK09579  779 ITLSDRARPRQLNQFQQLNSAII--SGFPIVSMGEAIETVQQIArEEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAI 856
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  883 VFLCLAALYESWSIPFSVMLVVPLGVIGALLaATFRGLTN-DVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIE 961
Cdd:PRK09579  857 IFLVLAAQFESFRDPLVILVTVPLSICGALI-PLFLGVSSmNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRRE 935
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 754494166  962 ATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:PRK09579  936 AIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTL 992
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
4-1016 1.04e-134

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 432.92  E-value: 1.04e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    4 FFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSd 83
Cdd:COG3696     8 FSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSIS- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   84 STGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQevqqqGVSVE----KSSSSFLMVVGVINTNGTMTQED---ISD 156
Cdd:COG3696    87 RFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPA-----GVTPElgpiSTGLGEIYQYTLESDPGKYSLMElrtLQD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  157 YVganMKDAISRTSGVGDVQLFG---SQYAMRIwmDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLggtpPVKGQQLNas 233
Cdd:COG3696   162 WV---IRPQLRSVPGVAEVNSFGgfvKQYQVLV--DPAKLRAYGLTLDDVIEALERNNANVGGGYI----ERGGQEYL-- 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  234 IIAQTRLTSADEFSKILLKvNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLA-TGANALDTATAIRAELKK 312
Cdd:COG3696   231 VRGIGLIRSLEDIENIVVK-TRNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMlKGENALEVIEAVKAKLAE 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  313 MEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINT 392
Cdd:COG3696   310 LKPSLPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  393 LTMFGMVLAIGLLVDDAIVVVENVERVMAE-----EGLPPKEATRKSMGQIQGALV-GIAMVLsAVFIPMAFFGGSTGAI 466
Cdd:COG3696   390 MSLGGLAIDFGIIVDGAVVMVENILRRLEEnraagTPRERLEVVLEAAREVRRPIFfATLIII-LVFLPIFTLEGVEGKL 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  467 YRQFSITIVSAMALSVLVALILTPALCATMLkpvqKGGHGEHKgffgwfNRMFDKSTHHYTDSVGNILRSTGRYLLLYII 546
Cdd:COG3696   469 FRPMALTVIFALLGALLLSLTLVPVLASLLL----RGKVPEKE------NPLVRWLKRLYRPLLRWALRHPKLVLAVALV 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  547 IVVGMAFLFVRLPSSFLPDEDQGVFLTMAQLPAGASQERTQKVLDEVTDyyLTKEKANVESVfavngFGFAGR------- 619
Cdd:COG3696   539 LLVLALALFPRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVER--ILKSFPEVESV-----VSRTGRaedatdp 611
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  620 -GQNTGIAFVSLKDWADRPGDENKVEAItgRAM-GTFSQIKdAMVFAFNLP---AIVEL--GTAT-------GFDFQLID 685
Cdd:COG3696   612 mGVNMSETFVILKPRSEWRSGRTKEELI--AEMrEALEQIP-GVNFNFSQPiqmRVDELlsGVRAdvavkifGDDLDVLR 688
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  686 QGGlghekltqarNQLFGEVAKHP---DLLVgVRPNGLedtPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFI 762
Cdd:COG3696   689 RLA----------EQIEAVLKTVPgaaDVQV-ERVTGL---PQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVY 754
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  763 DRGRVKKVYVMSEAQYRMLPNDINNWYVRGSNGQMVPFSSFSTSHWEYGSPRLERYNGLPSMEIlgQAAP-GRSTG---- 837
Cdd:COG3696   755 EGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVV--QANVrGRDLGsfva 832
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  838 EAMNLMEElASKLPAGIGYDWTGM-----SYQERLSgnqapALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGAL 912
Cdd:COG3696   833 EAQAKVAE-QVKLPPGYYIEWGGQfenlqRATARLA-----IVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGV 906
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  913 LAATFRGLtndvYFQ----VGLLTTIGLSAKNAILIVEFAKDLMEkEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPL 988
Cdd:COG3696   907 LALWLRGM----PLSvsagVGFIALFGVAVLNGVVLVSYINQLRA-EGLDLREAIIEGALERLRPVLMTALVAALGLLPM 981
                        1050      1060
                  ....*....|....*....|....*...
gi 754494166  989 VISSGAGSGAQNAVGTGVMGGMITATVL 1016
Cdd:COG3696   982 ALSTGPGSEVQRPLATVVIGGLITSTLL 1009
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
5-1016 4.94e-124

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 404.11  E-value: 4.94e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdS 84
Cdd:PRK10614    7 FIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSS-S 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   85 TGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGvSVEKSSSSFLMVVGVINTNGTMTQEDISDYVGANMKD 164
Cdd:PRK10614   86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRP-TYRKANPSDAPIMILTLTSDTYSQGQLYDFASTQLAQ 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  165 AISRTSGVGDVQLFGSQY-AMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQlggtppVKGQQLNASIIAQTRLTSA 243
Cdd:PRK10614  165 TISQIDGVGDVDVGGSSLpAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGA------VEDGTHRWQIQTNDELKTA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  244 DEFSKILLKVNQdGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSGLKI 323
Cdd:PRK10614  239 AEYQPLIIHYNN-GAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  324 VYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIG 403
Cdd:PRK10614  318 QIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATG 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  404 LLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVL 483
Cdd:PRK10614  398 FVVDDAIVVLENISRHL-EAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLL 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  484 VALILTPALCATMLKPVQKGGHGEHKGffgwFNRMFDKSTHHYTDSVGNILRSTgRYLLLYIIIVVGM-AFLFVRLPSSF 562
Cdd:PRK10614  477 VSLTLTPMMCAWLLKSSKPREQKRLRG----FGRMLVALQQGYGRSLKWVLNHT-RWVGVVLLGTIALnVWLYISIPKTF 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  563 LPDEDQGVFLTMAQLPAGAS-QERTQKVLDEVTdyyLTKEKANVESVfavngFGFAGRGQ-NTGIAFVSLKDWADRpgDE 640
Cdd:PRK10614  552 FPEQDTGRLMGFIQADQSISfQAMRGKLQDFMK---IIRDDPAVDNV-----TGFTGGSRvNSGMMFITLKPLSER--SE 621
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  641 NKVEAITgRAMGTFSQIKDAMVFafnLPAIVEL-----GTATGFDFQLI--DQGGLGH--EKLTQArnqlfgeVAKHPDl 711
Cdd:PRK10614  622 TAQQVID-RLRVKLAKEPGANLF---LMAVQDIrvggrQSNASYQYTLLsdDLAALREwePKIRKA-------LAALPE- 689
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  712 LVGVRPNGLEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAQYRMLPNDINNWYVR 791
Cdd:PRK10614  690 LADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVI 769
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  792 GSNGQMVPFSSFstSHWE-YGSPRLERYNGLPSMEILG-QAAPGRSTGEAMNLMEELASKL--PAGI--GYDWTGMSYQE 865
Cdd:PRK10614  770 NNEGKAIPLSYF--AKWQpANAPLSVNHQGLSAASTISfNLPTGKSLSDASAAIERAMTQLgvPSTVrgSFAGTAQVFQE 847
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  866 RLSGNQAPALYAIslIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIV 945
Cdd:PRK10614  848 TMNSQLILILAAI--ATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMV 925
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754494166  946 EFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVL 1016
Cdd:PRK10614  926 DFALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLL 996
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
5-1018 1.11e-117

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 387.55  E-value: 1.11e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdS 84
Cdd:PRK10503   16 FILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQS-S 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   85 TGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGV-SVEKSSSSFLMVVGVINTNGTMTQedISDYVGANMK 163
Cdd:PRK10503   95 GGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVySKVNPADPPIMTLAVTSTAMPMTQ--VEDMVETRVA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  164 DAISRTSGVGDVQLFGSQY-AMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLGGtpPVKGQQLNASiiaqTRLTS 242
Cdd:PRK10503  173 QKISQVSGVGLVTLSGGQRpAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDG--PTRAVTLSAN----DQMQS 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  243 ADEFSKILLKVnQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEPFFPSGLK 322
Cdd:PRK10503  247 AEEYRQLIIAY-QNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVK 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  323 IVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAI 402
Cdd:PRK10503  326 VTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIAT 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  403 GLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSV 482
Cdd:PRK10503  406 GFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISA 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  483 LVALILTPALCATMLKPvqkGGHGEHKGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLLLYIIIVVGMAFLFVRLPSSF 562
Cdd:PRK10503  485 VVSLTLTPMMCARMLSQ---ESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKGF 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  563 LPDEDQGVFLTMAQLPAGAS----QERTQKVLDEvtdyyLTKEKAnVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRpg 638
Cdd:PRK10503  562 FPVQDNGIIQGTLQAPQSSSfanmAQRQRQVADV-----ILQDPA-VQSLTSFVGVDGTNPSLNSARLQINLKPLDER-- 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  639 dENKVEAITGRAMGTFSQIKDAMVFafnLPAIVEL---GTATGFDFQLIDQGGlGHEKLTQARNQLFGEVAKHPDlLVGV 715
Cdd:PRK10503  634 -DDRVQKVIARLQTAVAKVPGVDLY---LQPTQDLtidTQVSRTQYQFTLQAT-SLDALSTWVPKLMEKLQQLPQ-LSDV 707
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  716 RPNGLEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNdfidrgrvkKVYVMSEaQYR-MLPND---------I 785
Cdd:PRK10503  708 SSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLIS---------TIYTQAN-QYRvVLEHNtentpglaaL 777
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  786 NNWYVRGSNGQMVPFSSFSTSHWEYGSPRLERYNGLPSMEILGQAAPGRSTGEAMNLMEELASKL--PAGIGYDWTG--M 861
Cdd:PRK10503  778 DTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLnlPADITTQFQGstL 857
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  862 SYQERLSGNQAPALYAIslIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNA 941
Cdd:PRK10503  858 AFQSALGSTVWLIVAAV--VAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNA 935
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754494166  942 ILIVEFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMITATVLAI 1018
Cdd:PRK10503  936 IMMIDFALAAEREQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTL 1012
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
17-1018 5.79e-82

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 288.58  E-value: 5.79e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    17 IIIMLAGGLAIL------KLPVAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQI 90
Cdd:TIGR00914   15 LVLLATLVMAILgiwsynRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLS-RYGLSQV 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166    91 TLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQ------GV------SVEKSSSSFLMVVGVINTNGTMTqedISDYV 158
Cdd:TIGR00914   94 TVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEmgpistGLgeiflyTVEAEEGARKKDGGAYTLTDLRT---IQDWI 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   159 ganMKDAISRTSGVGDVQLFG---SQYAMRIwmDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLggtpPVKGQQLnaSII 235
Cdd:TIGR00914  171 ---IRPQLRTVPGVAEVNSIGgyvKQFLVAP--DPEKLAAYGLSLADVVNALERNNQNVGAGYI----ERRGEQY--LVR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   236 AQTRLTSADEFSKILLKvNQDGSQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGANALDTATAIRAELKKMEP 315
Cdd:TIGR00914  240 APGQVQSMDDIRNIVIA-TGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   316 FFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTM 395
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   396 fgMVLAIGLLVDDAIVVVENVERVMAE----EGLPPKEATR-----KSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAI 466
Cdd:TIGR00914  399 --GALDFGLIVDGAVVIVENAHRRLAEaqhhHGRQLTLKERlhevfAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKM 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   467 YRQFSITIVSAMALSVLVALILTPALCATMLkpvqkGGHGEHKGffGWFNRMFDKSTHHYTDSVgniLRSTGRYLLLYII 546
Cdd:TIGR00914  477 FHPMAFTVVLALAGAMILSLTFVPAAVALFI-----RGKVAEKE--NRLMRVLKRRYEPLLERV---LAWPAVVLGAAAV 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   547 IVVGMAFLFVRLPSSFLPDEDQGVFLTMAQLPAGASqertqkvLDEVTDYYLTKEKAnVESVFAVNG-FGFAGRGQ---- 621
Cdd:TIGR00914  547 SIVLVVWIASRVGGEFIPSLNEGDLAYQALRIPGTS-------LAQSVAMQQTLEKL-IKSFPEVARvFAKTGTAEiatd 618
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   622 ----NTGIAFVSLK---DWadRPGDENKVEAI------TGRAMGTFSQIKDAMVFAFNlpaivELGTATGFDFQLIDQGG 688
Cdd:TIGR00914  619 pmppNASDTYIILKpesQW--PEGKKTKEDLIeeiqeaTVRIPGNNYEFTQPIQMRFN-----ELISGVRSDVAVKVFGD 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   689 LGHEKLTQArnQLFGEVAKHPDLLVGVRPNGLEDTPQYKINIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVK 768
Cdd:TIGR00914  692 DLDDLDATA--EKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRF 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   769 KVYVMSEAQYRMLPNDINNWYVR--GSNGQM---VPFSSFSTSHWEYGSPRLERYNGLPSMEILGQAApGRSTGEAMNLM 843
Cdd:TIGR00914  770 DIVIRLPESLRESPQALRQLPIPlpLSEDARkqfIPLSDVADLRVSPGPNQISRENGKRRVVVSANVR-GRDLGSFVDDA 848
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   844 EELAS---KLPAGIGYDWTGmSYQERLSGNQAPALYA-ISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRG 919
Cdd:TIGR00914  849 KKAIAeqvKLPPGYWITWGG-QFEQLQSATKRLQIVVpVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRG 927
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   920 LTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEkEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQ 999
Cdd:TIGR00914  928 IPLSISAAVGFIALSGVAVLNGLVMISFIRKLLE-EGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQ 1006
                         1050
                   ....*....|....*....
gi 754494166  1000 NAVGTGVMGGMITATVLAI 1018
Cdd:TIGR00914 1007 RPLATVVIGGIITATLLTL 1025
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
277-1017 4.59e-20

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 96.08  E-value: 4.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  277 IIAKFNGKPASGLgiklatgANALDTATAIRAELKKMEPffpSGLKIVY---PYDTTPFVKISIHEVVKTLVEAIILVFL 353
Cdd:COG1033   164 IVVTLDPDPLSSD-------LDRKEVVAEIRAIIAKYED---PGVEVYLtgfPVLRGDIAEAIQSDLAIFFPLALLLILL 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  354 VMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAeEGLPPKEATRK 433
Cdd:COG1033   234 LLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERR-KGLDKREALRE 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  434 SMGQiqgalVGIAMVLSAV-----FIPMAFfggSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPVQKGGHGEH 508
Cdd:COG1033   313 ALRK-----LGPPVLLTSLttaigFLSLLF---SDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKK 384
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  509 KGFFG-WFNRMFDKSTHHYTdsvgnilrstgRYLLLYIIIVVGMAFLFVRLPSSFLPDEDqgvfltmaqlpagasqertq 587
Cdd:COG1033   385 PPELGrLLAKLARFVLRRPK-----------VILVVALVLAVVSLYGISRLKVEYDFEDY-------------------- 433
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  588 kvLDEVTDYYLTKEKanVESVFAvngfgfagrgqNTGIAFVSLKdwADRPGDENKVEAItgRAMGTFSQikdamvfafNL 667
Cdd:COG1033   434 --LPEDSPIRQDLDF--IEENFG-----------GSDPLEVVVD--TGEPDGLKDPEVL--KEIDRLQD---------YL 485
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  668 PAIVELGTATGFDfqlidqgglgheKLTQARNQLFGEvakhpdllvgvrpnglEDTPQYKINIDQEKAQALGVSISDInt 747
Cdd:COG1033   486 ESLPEVGKVLSLA------------DLVKELNQALNE----------------GDPKYYALPESRELLAQLLLLLSSP-- 535
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  748 tlgaawGGSYVNDFIDrgrvkkvyvmseaqyrmlpndinnwyvrgSNGQMVPFSSFSTSHweygsprlerynglpsmeil 827
Cdd:COG1033   536 ------PGDDLSRFVD-----------------------------EDYSAARVTVRLKDL-------------------- 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  828 gqaapgrSTGEAMNLMEELASKL-----PAGIGYDWTGMSY-----QERLSGNQAPALyAISLIVVFLCLAALYESWSIP 897
Cdd:COG1033   561 -------DSEEIKALVEEVRAFLaenfpPDGVEVTLTGSAVlfaaiNESVIESQIRSL-LLALLLIFLLLLLAFRSLRLG 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  898 FSVML--VVPLGVIGALLAATfrgltnDVYFQVGLLT----TIGLSAKNAILIVEFAKDLMeKEGKGLIEATLEAVRMRL 971
Cdd:COG1033   633 LISLIpnLLPILLTFGLMGLL------GIPLNIATAVvasiALGIGVDYTIHFLSRYREER-RKGGDLEEAIRRALRTTG 705
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 754494166  972 RPILMTSLAFILGVMPLVISSGagsgaqnaVGTGVMGGMITATVLA 1017
Cdd:COG1033   706 KAILFTSLTLAAGFGVLLFSSF--------PPLADFGLLLALGLLV 743
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
291-496 1.13e-17

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 88.38  E-value: 1.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  291 IKLATGANALDTATAIRAELKKMEP-----FFPSGLKIVYpYDTTPFVkisIHEVVKTLVEAIILVFLVMYLFLQNFRAT 365
Cdd:COG1033   557 LKDLDSEEIKALVEEVRAFLAENFPpdgveVTLTGSAVLF-AAINESV---IESQIRSLLLALLLIFLLLLLAFRSLRLG 632
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  366 LIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGI 445
Cdd:COG1033   633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREER-RKGGDLEEAIRRALRTTGKAILFT 711
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 754494166  446 AMVLSAVFIPMAFfggSTGAIYRQFSITIVSAMALSVLVALILTPALCATM 496
Cdd:COG1033   712 SLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
299-494 2.80e-09

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 60.00  E-value: 2.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   299 ALDTATAIRAELKKMEPffPSGLKIvypYDTTP------FVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAV 372
Cdd:pfam03176  102 ADESVAAVRDAVEQAPP--PEGLKA---YLTGPaatvadLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTV 176
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   373 PVVLLGTFAILAAF----GFSINTLT-MFGMVLAIGLLVDDAIVVvenVERVMAE--EGLPPKEATRKSMGQIQGALVGI 445
Cdd:pfam03176  177 GLSLGAAQGLVAILahilGIGLSTFAlNLLVVLLIAVGTDYALFL---VSRYREElrAGEDREEAVIRAVRGTGKVVTAA 253
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 754494166   446 AMVLSAVFIPMAFfggSTGAIYRQFSITIVSAMALSVLVALILTPALCA 494
Cdd:pfam03176  254 GLTVAIAMLALSF---ARLPVFAQVGPTIAIGVLVDVLAALTLLPALLA 299
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
158-492 1.10e-08

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 59.27  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  158 VGANMKDAISRTSGVGDVQLF--GSQYAMRIWMDPNKLNNFQLTPVDVINAIKAQNAQVAAGQLggtppVKGQQ---LNA 232
Cdd:COG3696   690 LAEQIEAVLKTVPGAADVQVErvTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQV-----YEGERrfdIVV 764
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  233 SIIAQTRlTSADEFSKILLKVnQDGSQVRLRDVARVELG-GENYdiIAKFNGKPasglgiKLATGANALDTA-------- 303
Cdd:COG3696   765 RLPEELR-DDPEAIRNLPIPT-PSGAQVPLSQVADIEVVeGPNQ--ISRENGRR------RIVVQANVRGRDlgsfvaea 834
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  304 -TAIRAELKkmepfFPSG------------------LKIVYPYdttpfvkisihevvktlveAIILVFLVMYLFLQNFRA 364
Cdd:COG3696   835 qAKVAEQVK-----LPPGyyiewggqfenlqratarLAIVVPL-------------------ALLLIFLLLYLAFGSVRD 890
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  365 TLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMaEEGLPPKEATrksmgqIQGALVG 444
Cdd:COG3696   891 ALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLR-AEGLDLREAI------IEGALER 963
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 754494166  445 I------AMVLSAVFIPMAfFGGSTGA-IYRQFSITIVSAMALSVLVALILTPAL 492
Cdd:COG3696   964 LrpvlmtALVAALGLLPMA-LSTGPGSeVQRPLATVVIGGLITSTLLTLLVLPAL 1017
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
289-592 1.94e-08

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 58.24  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  289 LGIKLATGANALDTATAIRAELKKMEPffpSGLKIVY---PYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRAT 365
Cdd:COG2409   120 VTLDGDAGDEAAEAVDALRDAVAAAPA---PGLTVYVtgpAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAA 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  366 LIPTIAVPVVLLGTFAILAAFG--FSINTLT-MFGMVLAIGLLVDDAIVVV----ENVERvmaeeGLPPKEATRKSMGQI 438
Cdd:COG2409   197 LLPLLTAGLAVGVALGLLALLAafTDVSSFApNLLTMLGLGVGIDYALFLVsryrEELRA-----GEDREEAVARAVATA 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  439 Q------GALVGIAMvLSAVFIPMAFFggstgaiyRQFSITIVSAMALSVLVALILTPALCAT----MLKPVQKGGHGEH 508
Cdd:COG2409   272 GravlfsGLTVAIAL-LGLLLAGLPFL--------RSMGPAAAIGVAVAVLAALTLLPALLALlgrrVFWPRRPRRRRAA 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  509 KGFFGWFNRMfdksthhytdsVGNILRSTGRYLLLYIIIVVGMAFLFVRLPSSFlPDEDqgvfltmaQLPAGASQERTQK 588
Cdd:COG2409   343 APESGFWRRL-----------ARAVVRRPVPVLVAAVAVLLALALPALGLRLGL-PDAD--------SLPADSPSRQGYD 402

                  ....
gi 754494166  589 VLDE 592
Cdd:COG2409   403 ALAE 406
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
258-492 1.45e-07

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 54.99  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   258 SQVRLRDVARVELGGENYDIIAKFNGKPASGLGIKLATGAnaldtatairaelkkmepfFPSGLKIVYPYDTTP-FVKIS 336
Cdd:TIGR01129  186 NKVVSAPTIQEAITGGSGQITGNFTAEEANDLALVLRSGA-------------------LPAPLQILEERTIGPsLGADS 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   337 IHEVVKTLVEAIILVFLVMYLFLQNFraTLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENV 416
Cdd:TIGR01129  247 IEAGIKAGLIGLVLVLVFMILYYRLF--GLIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAVDANVLIYERI 324
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   417 ERVMAeEGLPPKEAT----RKSMGQIQGAlvGIAMVLSAVFipMAFFGgsTGAIyRQFSITIVSAMALSVLVALILTPAL 492
Cdd:TIGR01129  325 KEELR-LGKSVRQAIeagfERAFSTIFDA--NITTLIAALI--LYVFG--TGPV-KGFAVTLAIGIIASLFTALVFTRLL 396
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
249-503 1.70e-07

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 55.54  E-value: 1.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   249 ILLKVNQDG--SQVRLRDVARVELGgENYDIIAKFNGKPASGLGIKLA---TGANALDTATAIRAELKkmepfFPSGLKI 323
Cdd:TIGR00914  791 IPLPLSEDArkQFIPLSDVADLRVS-PGPNQISRENGKRRVVVSANVRgrdLGSFVDDAKKAIAEQVK-----LPPGYWI 864
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   324 VYpydTTPFVKI-SIHEVVKTLVE-AIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLA 401
Cdd:TIGR00914  865 TW---GGQFEQLqSATKRLQIVVPvTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIAL 941
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   402 IGLLVDDAIVVVENVeRVMAEEGLPPKEATrksmgqIQGALVGI------AMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475
Cdd:TIGR00914  942 SGVAVLNGLVMISFI-RKLLEEGPSLDEAV------YEGALTRVrpvlmtALVASLGFVPMAIATGTGAEVQRPLATVVI 1014
                          250       260
                   ....*....|....*....|....*...
gi 754494166   476 SAMALSVLVALILTPALCATMLKPVQKG 503
Cdd:TIGR00914 1015 GGIITATLLTLFVLPALYRLVHRRRHKG 1042
SecD COG0342
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ...
336-492 5.36e-06

Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440111 [Multi-domain]  Cd Length: 434  Bit Score: 50.11  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  336 SIHEVVKTLVEAIILVFLVMYLFLQNFRatLIPTIAVPVVLLGTFAILAAFGFsinTLTM---FGMVLAIGLLVDDaivv 412
Cdd:COG0342   269 SIEKGLIAGLIGLLLVALFMLLYYRLPG--LVANIALALNVVLLLGVLSLLGA---TLTLpgiAGIILTIGMAVDA---- 339
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  413 veNV---ERVMAE--EGLPPKEAT----RKSMGQIQGALV--GIAMVlsavfiPMAFFGgsTGAIyRQFSITIVSAMALS 481
Cdd:COG0342   340 --NVlifERIREElrAGRSLRAAIeagfKRAFSTILDANVttLIAAV------VLFVLG--TGPV-KGFAVTLILGILIS 408
                         170
                  ....*....|.
gi 754494166  482 VLVALILTPAL 492
Cdd:COG0342   409 MFTAVPVTRPL 419
COG4258 COG4258
Predicted exporter [General function prediction only];
347-491 6.06e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 50.24  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  347 AIILVFLVMYLFLQNFRATLIpTIAVPVV-LLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIvvvenverVMAEEGL 425
Cdd:COG4258   648 ALLLILLLLLLRLRSLRRALR-VLLPPLLaVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL--------FFTEGLL 718
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 754494166  426 PPKEATRksmgqiqgALVGIAM-VLSAV--FIPMAFfgGSTGAIyRQFSITIVSAMALSVLVALILTPA 491
Cdd:COG4258   719 DKGELAR--------TLLSILLaALTTLlgFGLLAF--SSTPAL-RSFGLTVLLGILLALLLAPLLAPR 776
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
317-492 3.58e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.91  E-value: 3.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   317 FPSGLKIVY---PYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPtiaVPVVLLGTFAILAAFG-----F 388
Cdd:TIGR00921  169 PPSGKFLDVtgsPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLP---LVIILFGVAWVLGIMGwlgipL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   389 SINTLTMFGMVLAIGLlvdDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFfggSTGAIYR 468
Cdd:TIGR00921  246 YATTLLAVPMLIGVGI---DYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALAL---SEFPMVS 319
                          170       180
                   ....*....|....*....|....
gi 754494166   469 QFSITIVSAMALSVLVALILTPAL 492
Cdd:TIGR00921  320 EFGLGLVAGLITAYLLTLLVLPAL 343
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
341-492 4.09e-05

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 47.74  E-value: 4.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   341 VKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERvm 420
Cdd:pfam02460  642 IQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVR-- 719
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754494166   421 aEEGLPPKEATRKSMGQI-----QGALVGIAMVLSAVFIPmaffggsTGAIyRQFSITIVSAMALSVLVALILTPAL 492
Cdd:pfam02460  720 -SRGDTPAERVVDALEALgwpvfQGGLSTILGVLVLLFVP-------SYMV-VVFFKTVFLVVAIGLLHGLFILPII 787
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
336-557 1.19e-04

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 45.99  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  336 SIHEVVKTLVEAIILVFLVMYLFLQnfRATLIPTIAVPVVLLGTFAILAAFGFsinTLTM---FGMVLAIGLLVDDAIVV 412
Cdd:PRK13024  264 AIDAGIIAGIIGFALIFLFMLVYYG--LPGLIANIALLLYIFLTLGALSSLGA---VLTLpgiAGLVLGIGMAVDANVLI 338
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  413 VENVErvmaEE---GLPPKEATRKSMgqiQGALVGIA-----MVLSAV--FipmaFFGgsTGAIyRQFSITIVSAMALSV 482
Cdd:PRK13024  339 FERIK----EElrkGKSLKKAFKKGF---KNAFSTILdsnitTLIAAAilF----FFG--TGPV-KGFATTLIIGILASL 404
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754494166  483 LVALILTPALCATMLKpvqkggHGEHKGFFGWFNRMFDKSTHHYTDSVGNIL---RSTGRYLLLYIIIVVGMAFLFVR 557
Cdd:PRK13024  405 FTAVFLTRLLLELLVK------RGDKKPFLFGVKKKKIHNINEGVTIFDRIDfvkKRKWFLIFSIVLVIAGIIIFFIF 476
2A0604s01 TIGR00916
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ...
336-486 2.32e-04

protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273336 [Multi-domain]  Cd Length: 192  Bit Score: 43.40  E-value: 2.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   336 SIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLgTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVEN 415
Cdd:TIGR00916   45 LIKAGIIALLIGLVLVLLYMLLRYEWRGAIAAIAALVHDVIL-ILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVVIFDR 123
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754494166   416 V-ERVMAEEGLPPKEATRKSmgqIQGALVGIAMVLSAVFIPMA---FFGGstGAIyRQFSITIVSAMALSVLVAL 486
Cdd:TIGR00916  124 IrEELRKYKGRTFREAINLG---INQTLSRIIDTNVTTLLAVLalyVFGG--GAI-KGFALTLGIGVIAGTYSSI 192
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
848-1018 7.17e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 43.67  E-value: 7.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   848 SKLPAGIGYDWTG---MSYQ-ERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTND 923
Cdd:TIGR00921  167 TNPPSGKFLDVTGspaINYDiEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLY 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   924 VYFQVGLLTTIGLsaknAILIVEFAKDLMEKE---GKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISsgaGSGAQN 1000
Cdd:TIGR00921  247 ATTLLAVPMLIGV----GIDYGIQTLNRYEEErdiGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALS---EFPMVS 319
                          170
                   ....*....|....*...
gi 754494166  1001 AVGTGVMGGMITATVLAI 1018
Cdd:TIGR00921  320 EFGLGLVAGLITAYLLTL 337
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
344-490 7.81e-04

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 43.56  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166  344 LVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEE 423
Cdd:PRK10614  856 ILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNG 935
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754494166  424 GLPPKEATrksmgqIQGALV---GIAMV-LSAVF--IPMAFFGGStGAIYRQ-FSITIVSAMALSVLVALILTP 490
Cdd:PRK10614  936 NLTAQEAI------FQACLLrfrPIMMTtLAALFgaLPLVLSGGD-GAELRQpLGITIVGGLVMSQLLTLYTTP 1002
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
336-505 9.40e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 39.98  E-value: 9.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   336 SIHEVVKTLVEAIILVFLVMYLFLQNFR---ATLIPTIavpVVLLGTFAILAAFGFSINTLTMFGMVLAIGLLVDDAIVV 412
Cdd:TIGR03480  267 VSEGATVAGLLSFVLVLVLLWLALRSPRlvfAVLVTLI---VGLILTAAFATLAVGHLNLISVAFAVLFIGLGVDFAIQF 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754494166   413 VENVeRVMAEEGLPPKEATRKSMGQIQGALVgIAMVLSAV----FIPMAFFGGStgaiyrQFSITIVSAMALSVLVALIL 488
Cdd:TIGR03480  344 SLRY-REERFRGGNHREALSVAARRMGAALL-LAALATAAgffaFLPTDYKGVS------ELGIIAGTGMFIALFVTLTV 415
                          170
                   ....*....|....*..
gi 754494166   489 TPALCaTMLKPVQKGGH 505
Cdd:TIGR03480  416 LPALL-RLLRPPRRRKP 431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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