DNA polymerase III subunit delta interacts with the delta' and gamma subunits and is part of the clamp-loading complex, which assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork
DNA polymerase III, delta subunit; DNA polymerase III delta (holA) and delta prime (holB) ...
32-330
2.85e-81
DNA polymerase III, delta subunit; DNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX. The delta, delta prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp. [DNA metabolism, DNA replication, recombination, and repair]
:
Pssm-ID: 273455 [Multi-domain] Cd Length: 302 Bit Score: 249.48 E-value: 2.85e-81
DNA polymerase III, delta subunit; DNA polymerase III delta (holA) and delta prime (holB) ...
32-330
2.85e-81
DNA polymerase III, delta subunit; DNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX. The delta, delta prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273455 [Multi-domain] Cd Length: 302 Bit Score: 249.48 E-value: 2.85e-81
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
20-188
1.98e-34
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.
Pssm-ID: 428788 [Multi-domain] Cd Length: 174 Bit Score: 124.32 E-value: 1.98e-34
helical lid domain of DNA polymerase III subunits delta; DNA polymerase III subunit delta is ...
140-204
2.28e-20
helical lid domain of DNA polymerase III subunits delta; DNA polymerase III subunit delta is part of the DNA polymerase III holoenzyme. the delta subunit id required for ring opening and binds the beta subunit. It is a member of the clamp-loader clade of the AAA+ superfamily.
Pssm-ID: 350840 [Multi-domain] Cd Length: 65 Bit Score: 83.24 E-value: 2.28e-20
DNA polymerase III, delta subunit; DNA polymerase III delta (holA) and delta prime (holB) ...
32-330
2.85e-81
DNA polymerase III, delta subunit; DNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX. The delta, delta prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273455 [Multi-domain] Cd Length: 302 Bit Score: 249.48 E-value: 2.85e-81
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
20-188
1.98e-34
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.
Pssm-ID: 428788 [Multi-domain] Cd Length: 174 Bit Score: 124.32 E-value: 1.98e-34
helical lid domain of DNA polymerase III subunits delta; DNA polymerase III subunit delta is ...
140-204
2.28e-20
helical lid domain of DNA polymerase III subunits delta; DNA polymerase III subunit delta is part of the DNA polymerase III holoenzyme. the delta subunit id required for ring opening and binds the beta subunit. It is a member of the clamp-loader clade of the AAA+ superfamily.
Pssm-ID: 350840 [Multi-domain] Cd Length: 65 Bit Score: 83.24 E-value: 2.28e-20
Processivity clamp loader gamma complex DNA pol III C-term; This domain lies at the C-terminus ...
212-328
2.09e-17
Processivity clamp loader gamma complex DNA pol III C-term; This domain lies at the C-terminus of the delta subunit of the DNA polymerase III clamp loader gamma complex. Within the complex the several C-terminal domains, of gamma, delta and delta' form a helical scaffold, on which the rest of he subunits are hung. The gamma complex, an AAA+ ATPase, is the bacterial homolog of the eukaryotic replication factor C that loads the sliding clamp (beta, homologous to PCNA) onto DNA.
Pssm-ID: 405522 Cd Length: 125 Bit Score: 77.34 E-value: 2.09e-17
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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