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Conserved domains on  [gi|754934682|ref|WP_042291414|]
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MULTISPECIES: ISC system 2Fe-2S type ferredoxin [Citrobacter]

Protein Classification

ISC system 2Fe-2S type ferredoxin( domain architecture ID 10797691)

ISC system 2Fe-2S type ferredoxin is an iron-sulfur protein that transfers electrons in a wide variety of metabolic reactions, and is associated with and essential to the ISC system

CATH:  3.10.20.30
Gene Ontology:  GO:0016226|GO:0051536|GO:0046872|GO:0009055
SCOP:  3000113

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 7.65e-67

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 196.55  E-value: 7.65e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682    2 PKIVILPHQDLCPDGAVLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESTEEEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 754934682   82 ESRLSCQARVTEDDLVVEIPRYTINHAREH 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 7.65e-67

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 196.55  E-value: 7.65e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682    2 PKIVILPHQDLCPDGAVLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESTEEEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 754934682   82 ESRLSCQARVTEDDLVVEIPRYTINHAREH 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-108 5.19e-28

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 98.64  E-value: 5.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  14 PDGA--VLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIV--REGFDSLPESTEEEDDMLDKAWGLEPESRLSCQA 89
Cdd:PLN02593   8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                         90       100
                 ....*....|....*....|.
gi 754934682  90 RVTE--DDLVVEIPRYTINHA 108
Cdd:PLN02593  88 IAKPelDGMRLALPAATRNFA 108
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 4.08e-25

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 90.29  E-value: 4.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682   1 MPKIVILPHqdlcpdGAVLEAKTGETILDVALRNGIEIEHACEkSCACTTCHCIVREGfdslpESTEEEDDMLDkAWGLE 80
Cdd:COG0633    1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEG-----EVDHREEDALS-DEERA 67

                         90       100
                 ....*....|....*....|.
gi 754934682  81 PESRLSCQARVTeDDLVVEIP 101
Cdd:COG0633   68 AGSRLACQARPT-SDLVVELP 87
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 4.08e-16

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 67.42  E-value: 4.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  14 PDGAVLEAKTGETILDVALRNGIEIEHACEKScACTTCHCIVREGfdslpeSTEEEDDMLDKAWGLEPESRLSCQARVTe 93
Cdd:cd00207    7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQTRVT- 78


                 ....*.
gi 754934682  94 DDLVVE 99
Cdd:cd00207   79 DGLVIE 84
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
12-92 1.06e-10

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 53.30  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682   12 LCPDGAVLEAKTGET-ILDVALRNGIEIEHACEKSCaCTTCHCIVREGFDsLPESTEEEDDMLDKAWGLepesrLSCQAR 90
Cdd:pfam00111   3 INGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGED-QSDQSFLEDDELAAGYVV-----LACQTY 75


                  ..
gi 754934682   91 VT 92
Cdd:pfam00111  76 PK 77
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 7.65e-67

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 196.55  E-value: 7.65e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682    2 PKIVILPHQDLCPDGAVLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESTEEEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 754934682   82 ESRLSCQARVTEDDLVVEIPRYTINHAREH 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-108 5.19e-28

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 98.64  E-value: 5.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  14 PDGA--VLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIV--REGFDSLPESTEEEDDMLDKAWGLEPESRLSCQA 89
Cdd:PLN02593   8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                         90       100
                 ....*....|....*....|.
gi 754934682  90 RVTE--DDLVVEIPRYTINHA 108
Cdd:PLN02593  88 IAKPelDGMRLALPAATRNFA 108
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 4.08e-25

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 90.29  E-value: 4.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682   1 MPKIVILPHqdlcpdGAVLEAKTGETILDVALRNGIEIEHACEkSCACTTCHCIVREGfdslpESTEEEDDMLDkAWGLE 80
Cdd:COG0633    1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEG-----EVDHREEDALS-DEERA 67

                         90       100
                 ....*....|....*....|.
gi 754934682  81 PESRLSCQARVTeDDLVVEIP 101
Cdd:COG0633   68 AGSRLACQARPT-SDLVVELP 87
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 4.08e-16

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 67.42  E-value: 4.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  14 PDGAVLEAKTGETILDVALRNGIEIEHACEKScACTTCHCIVREGfdslpeSTEEEDDMLDKAWGLEPESRLSCQARVTe 93
Cdd:cd00207    7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQTRVT- 78


                 ....*.
gi 754934682  94 DDLVVE 99
Cdd:cd00207   79 DGLVIE 84
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 14-101 2.36e-15

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 69.89  E-value: 2.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  14 PDGAVLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIVREG-FDSLPES----TEEEddmLDKAWglepesRLSCQ 88
Cdd:COG2871   41 GDGKEIEVEEGQTLLDALLRQGIFLPSACGGGGTCGQCKVKVLEGgGDILPTEtfhlSDRE---RKEGY------RLACQ 111

                         90
                 ....*....|...
gi 754934682  89 ARVtEDDLVVEIP 101
Cdd:COG2871  112 VKV-KSDMEIEVP 123
COG3894 COG3894
Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain ...
 1-101 1.66e-14

Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain [Function unknown];


Pssm-ID: 443101 [Multi-domain]  Cd Length: 621  Bit Score: 67.91  E-value: 1.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682   1 MPKIVILPHqdlcpdGAVLEAKTGETILDVALRNGIEIEHACEKSCACTTCHCIVREGFDSLPesTEEEDDMLDKAwGLE 80
Cdd:COG3894    3 KVKVTFLPS------GKRVEVEAGTTLLDAAREAGVDIDAPCGGRGTCGKCKVKVEEGEFSPV--TEEERRLLSPE-ELA 73

                         90       100
                 ....*....|....*....|.
gi 754934682  81 PESRLSCQARVTEdDLVVEIP 101
Cdd:COG3894   74 EGYRLACQARVLG-DLVVEVP 93
PTZ00490 PTZ00490
Ferredoxin superfamily; Provisional
 27-106 6.28e-11

Ferredoxin superfamily; Provisional


Pssm-ID: 185668  Cd Length: 143  Bit Score: 55.26  E-value: 6.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  27 ILDVAlrnGIEIEHACEKSCACTTCHCIVREG-FDSLPESTEEEDDMLDKAWGLEPESRLSCQARVTE--DDLVVEIPRY 103
Cdd:PTZ00490  62 LRDVA---KLDVEGTCNGCMQCATCHVYLSAAsFKKLGGPSEEEEDVLAKALDVKETSRLACQVDLTPemDGLEVELPSY 138


                 ...
gi 754934682 104 TIN 106
Cdd:PTZ00490 139 VTN 141
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
12-92 1.06e-10

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 53.30  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682   12 LCPDGAVLEAKTGET-ILDVALRNGIEIEHACEKSCaCTTCHCIVREGFDsLPESTEEEDDMLDKAWGLepesrLSCQAR 90
Cdd:pfam00111   3 INGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGED-QSDQSFLEDDELAAGYVV-----LACQTY 75


                  ..
gi 754934682   91 VT 92
Cdd:pfam00111  76 PK 77
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 14-104 1.09e-10

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 56.80  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  14 PDGAVLEAKTGETILDVALRNGIEIEHACeKSCACTTCHCIVREGfdslpesTEEEDDMLDKAWGLEPESR---LSCQAR 90
Cdd:PRK07609   9 PSGRQFTAEPDETILDAALRQGIHLPYGC-KNGACGSCKGRLLEG-------EVEQGPHQASALSGEERAAgeaLTCCAK 80

                         90
                 ....*....|....
gi 754934682  91 VTEdDLVVEIPRYT 104
Cdd:PRK07609  81 PLS-DLVLEAREVP 93
PRK05713 PRK05713
iron-sulfur-binding ferredoxin reductase;
23-100 9.19e-05

iron-sulfur-binding ferredoxin reductase;


Pssm-ID: 235575 [Multi-domain]  Cd Length: 312  Bit Score: 39.71  E-value: 9.19e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 754934682  23 TGETILDVALRNGIEIEHACEK-SCACTTCHCIVREGFDSLPESTEEEDDmlDKAWglepesRLSCQARVTEdDLVVEI 100
Cdd:PRK05713  15 AGSNLLDALNAAGVAVPYSCRAgSCHACLVRCLQGEPEDALPEALAAEKR--EQGW------RLACQCRVVG-DLRVEV 84
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
15-53 1.07e-04

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 39.69  E-value: 1.07e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 754934682  15 DGAVLEAKTGETILDVALRNGIEIEHACEKSCACTTCHC 53
Cdd:PRK08493   7 NGKECEAQEGEYILNVARRNGIFIPAICYLSGCSPTLAC 45
antC PRK11872
anthranilate 1,2-dioxygenase electron transfer component AntC;
25-94 5.04e-04

anthranilate 1,2-dioxygenase electron transfer component AntC;


Pssm-ID: 183350 [Multi-domain]  Cd Length: 340  Bit Score: 37.80  E-value: 5.04e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754934682  25 ETILDVALRNGIEIEHACEKScACTTCHCIVREGFDSLPESTEEEDDMLDkawgLEPESRLSCQARVTED 94
Cdd:PRK11872  23 ELLLDAALRNGINLPLDCREG-VCGTCQGRCESGIYSQDYVDEDALSERD----LAQRKMLACQTRVKSD 87
PTZ00038 PTZ00038
ferredoxin; Provisional
 14-79 5.63e-03

ferredoxin; Provisional


Pssm-ID: 240237 [Multi-domain]  Cd Length: 191  Bit Score: 34.43  E-value: 5.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754934682  14 PDG-AVLEAKTGETILDVALRNGIEIEHACeKSCACTTCHCIVREGFDSLPESTEEEDDMLDKAWGL 79
Cdd:PTZ00038 103 PDGeKVIECDEDEYILDAAERQGVELPYSC-RGGSCSTCAAKLLEGEVDNEDQSYLDDEQLKKGYCL 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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