|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
21-396 |
2.38e-91 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 279.85 E-value: 2.38e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAG 97
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASasaVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 98 CALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLV 177
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 178 LIGALMCV-SLCWLPETLPEAKRvKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHY 256
Cdd:cd17320 161 LLGLLLLLlVLLFLPETLPEEKR-KPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 257 GWLFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAA 336
Cdd:cd17320 240 GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 337 ALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSATLALRA 396
Cdd:cd17320 320 ALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-398 |
9.76e-76 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 239.82 E-value: 9.76e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 29 AFTSLSTDIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSIT 105
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGvsaGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 106 QIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCV 185
Cdd:PRK11102 81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 186 SLCWL-PETLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALNI 264
Cdd:PRK11102 161 LVFFFiPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 265 VGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESgGIVAIIITIFLLFSMNGIIAATSTAAALDAVPNI 344
Cdd:PRK11102 241 VFLFVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDL-GFWALVVGVAAFVGCVSMISSNAMAVILDEFPHM 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 754952400 345 AGSASALIGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSATLALRAKR 398
Cdd:PRK11102 320 AGTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYLYASR 373
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
15-389 |
7.12e-69 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 222.26 E-value: 7.12e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 15 HTGLSFILILSGLMAFTSLSTDIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLF 91
Cdd:TIGR00710 1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLStpaSIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 92 IIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHA 171
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 172 VFWLLVLIGALMCVSLCW-LPETLPEAKRVKASLTgaFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYH 250
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFiLPETLPYEARIQISTY--FETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 251 VDPQHYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIA 330
Cdd:TIGR00710 239 VSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMIS 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 754952400 331 ATSTAAALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLS 389
Cdd:TIGR00710 319 SIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVS 377
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
16-390 |
1.30e-41 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 150.81 E-value: 1.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 16 TGLSFILILSGLMAFTSLSTDIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFI 92
Cdd:PRK11043 3 PSKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQtsaSAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 93 IGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAV 172
Cdd:PRK11043 83 LGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 173 FWLLVLIGALMCVSLCWLPETLPEAKRVKASLTgafrnYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVyISYYHVD 252
Cdd:PRK11043 163 FATLFAITLLLILPTLRLKPSKKARKQSQDALT-----FKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFI-LEQMGYS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 253 PQHYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAAT 332
Cdd:PRK11043 237 PADIGLSYVPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 754952400 333 STAAALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSA 390
Cdd:PRK11043 317 VVAQALRPFPQATGKAAALQNTLQLGLCFLASLLVSALISTPLLTTGSVMLSTVVLVA 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-360 |
1.11e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 142.04 E-value: 1.11e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 11 ATASHTGLSFILILSGLMAFTSLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIG 87
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASpaqAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 88 MVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLS 167
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 168 TWHAVFWLLVLIGALMCV-SLCWLPETLPEAKRvkasltGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYI 246
Cdd:COG2814 162 GWRWVFLVNAVLALLALLlLLRLLPESRPAARA------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 247 SYYHVDPQHYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALlvkleSGGIVAIIITIFLLFSMN 326
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-----AGSLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|....*
gi 754952400 327 GIIAATSTAAALDAVP-NIAGSASALIGALQYGSG 360
Cdd:COG2814 311 GLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
14-365 |
2.87e-35 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 133.88 E-value: 2.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 14 SHTGLSFILILsgLMAFTSLSTDIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVL 90
Cdd:PRK11652 5 RNVNLLFMLVL--LVAVGQMAQTIYVPAIADMARDLNvreGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 91 FIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWH 170
Cdd:PRK11652 83 FILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 171 AVFWLLVLIGALMCVSLC-WLPETLPEAKRVKASLTGafrnYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYY 249
Cdd:PRK11652 163 ACYLFLLLLGAGVTFSMArWMPETRPADARRTRVLAS----YRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 250 HVDPQHYGWLFALNIVGVMAMSVLNRRLVQRHPleQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGII 329
Cdd:PRK11652 239 GLSSMTVSILFILPIPAAFFGAWFAGRPNKRFS--TLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGML 316
|
330 340 350
....*....|....*....|....*....|....*..
gi 754952400 330 AATSTAAALDAVPNIAGSASALIGALQ-YGSGIISSL 365
Cdd:PRK11652 317 FPLATSGAMEPFPYLAGTAGALLGGLQnIGSGLAALL 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-281 |
2.71e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 111.51 E-value: 2.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 20 FILILSGLMAFTSLStdIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSA 96
Cdd:cd17474 2 YAVFFATLLAVLGVS--IVDPILPAIAEALGaspAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 97 GCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGqIIRLSTWHAVFWLL 176
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 177 VLIGALMCVSLCWLPEtlPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHY 256
Cdd:cd17474 159 AALIPVAFLAILFLLP--EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260
....*....|....*....|....*
gi 754952400 257 GWLFALNIVGVMAMSVLNRRLVQRH 281
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKR 261
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
8-290 |
8.66e-26 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 107.72 E-value: 8.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 8 SPVATASHTGLSFILILSGLMAFTSLSTDIYLPAMPTMATDLHGNVEL---TITGFLVGFTIAQLIWGPISDHLGRRKPL 84
Cdd:PRK15402 2 SPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWvptSMTAYLAGGMFLQWLLGPLSDRIGRRPVM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 85 FIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQII 164
Cdd:PRK15402 82 LAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 165 RLSTWHAVFWLLVLIGALMCVSLC-WLPETLpEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPF 243
Cdd:PRK15402 162 HVLPWRGMFVLFAALAALSFFGLWrAMPETA-GRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 754952400 244 VYISYYHVDPQHYGWL----FALNIVGVMAMSvlnrRLVQRHPLEQLLKYA 290
Cdd:PRK15402 241 ILISGEQLSSYEYGLLqvpvFGALIAGNLTLA----RLTSRRPLRSLIRMG 287
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
21-278 |
4.84e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 103.74 E-value: 4.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAG 97
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASsaqLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 98 CALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLV 177
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 178 LIGALMCVSLCWLPETLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYG 257
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260
....*....|....*....|.
gi 754952400 258 WLFALNIVGVMAMSVLNRRLV 278
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLL 276
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
21-194 |
4.80e-23 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 99.19 E-value: 4.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLSTDIYLPAMPTMATDLHGNVE---LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAG 97
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEvanLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 98 CALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLV 177
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....*...
gi 754952400 178 LIGALMCVSLC-WLPETL 194
Cdd:cd17323 161 IISGFCLILIFlFLPIVL 178
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
20-394 |
6.34e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.78 E-value: 6.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 20 FILILSGLMAFTSLstdiYLPA--MPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIG 94
Cdd:cd17324 2 LALALAAFAIGTTE----YVIQglLPDIARDFGvsvAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 95 SAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFW 174
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 175 LLVLIGALMCVSLCWLpetLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQ 254
Cdd:cd17324 158 AIAVLALLAALLLWRL---LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 255 HYGWLFALNIVGVMAMSVLNRRLVQRHPleqllKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATST 334
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGG-----RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754952400 335 AAALDAVPNIAGSASAL-IGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSATLAL 394
Cdd:cd17324 310 TRVLRLAPEARGLASSLyLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-397 |
1.32e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.03 E-value: 1.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 24 LSGLMAFTSLSTDIYLPAMPTMATDLHGNVELT---ITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCAL 100
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIgliVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 101 STSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLL-VLI 179
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCaALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 180 GALMCVSLCWLPETLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWL 259
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 260 FALNIVGVMAMSVLNRRLVQRHPleqllKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAAALD 339
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIG-----RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754952400 340 AVPNIA-GSASALIGALQYGSGIISSLLLAAFSD--GTPWTMaWIIALFTLLSATLALRAK 397
Cdd:cd17325 316 IVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDafGFATPF-LAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
22-370 |
4.08e-22 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 96.47 E-value: 4.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 22 LILSGLMAftSLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGC 98
Cdd:cd17321 1 LLLAVFLA--ALDVTIVNVALPTIARDLGASpsqLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVL 178
Cdd:cd17321 79 ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 179 IGALMcvslcwlpetlpeakrvkasltgafrnyrsLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGW 258
Cdd:cd17321 159 IGLVA------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 259 LFALNIVGVMAMSVLNRRLVQRHPLEQLLkyATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAAAL 338
Cdd:cd17321 209 ALLPLALAMLVAAPLAGRLADRFGPRLVL--VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330 340 350
....*....|....*....|....*....|...
gi 754952400 339 DAVP-NIAGSASALIGALQYGSGIISSLLLAAF 370
Cdd:cd17321 287 SSVPkEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
22-185 |
1.16e-21 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 94.94 E-value: 1.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 22 LILSGLMAftSLSTDIYLPAMPTMATDLHG--NVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCA 99
Cdd:cd17502 1 LMLALFLA--ALDQTIVATALPTIVAEFGGlsLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 100 LSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLI 179
Cdd:cd17502 79 LAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPI 158
|
....*.
gi 754952400 180 GALMCV 185
Cdd:cd17502 159 GGLALA 164
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-398 |
2.28e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.17 E-value: 2.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLSTDIYLPAMPTMATDLHGNVE---LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAG 97
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAqlgLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 98 CALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLV 177
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 178 LIGALMCVslcwlpetlpeakrvkasltgafrnyrsllsnGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYG 257
Cdd:COG2271 172 LPGLLLAL--------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 258 WLFALNIVGVMAMSVLNRRLVQRhpLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAAA 337
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 754952400 338 LDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMA-WIIALFTLLSATLALRAKR 398
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAfLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-364 |
3.78e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.64 E-value: 3.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 24 LSGLMAFTSLSTDIYLPAMP-TMATDLHGNVE---LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCA 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTeigLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 100 LSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLI 179
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 180 GALMCVSLC-WLPETLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPfVYISYYHVDPQHYGW 258
Cdd:pfam07690 161 SLLAAVLLLlPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 259 LFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIItIFLLFSMNGIIAATSTAAAL 338
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*.
gi 754952400 339 DAVPNIAGSASALIGALQYGSGIISS 364
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
60-193 |
3.90e-21 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 88.48 E-value: 3.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 60 FLVGFTIAQLIWGPIS----DHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFAR 135
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 754952400 136 TRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGAL-MCVSLCWLPET 193
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAaFILLAFLLPET 141
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-394 |
2.28e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 91.72 E-value: 2.28e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLSTDIYLPAMPTMATDLHGNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCAL 100
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 101 STSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQII--RLSTWHAVFWLLVL 178
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 179 IGALMCVSLCWLPETLPEAKRVK---ASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQH 255
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKneeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 256 YGWLFALNIVGVMAMSVLNRRLVQRHpleQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTA 335
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRL---IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 336 AALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTP-WTMAWIIALFTLLSATLAL 394
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILL 377
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
22-258 |
2.43e-19 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 89.12 E-value: 2.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 22 LILSGLMAFtsLSTDIYLPAMPTMATDLHGNVEL---TITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGC 98
Cdd:PRK15403 21 LILYDFAAY--LTTDLIQPGIINVVRDFNADVSLapaSVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHavfWLLVL 178
Cdd:PRK15403 99 LFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWK---VLFAI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 179 IGALMCVSLCWLPETLPEAKR---VKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQH 255
Cdd:PRK15403 176 IAVMGLIAFVGLLLAMPETVKrgaVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQ 255
|
...
gi 754952400 256 YGW 258
Cdd:PRK15403 256 FAW 258
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
22-187 |
1.36e-18 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 86.48 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 22 LILSGLMAftSLSTDIYLPAMPTMATDLHGNVE---LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGC 98
Cdd:cd17503 1 LLLGAFMA--ILDTTIVNVALPTIMGDLGASLDtvqWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVL 178
Cdd:cd17503 79 GLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP 158
|
....*....
gi 754952400 179 IGALMCVSL 187
Cdd:cd17503 159 IGILALLLA 167
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-398 |
1.59e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.39 E-value: 1.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLST-DIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSA 96
Cdd:COG2223 6 VLLLATLAFFLAFGVwYLWSVLAPPLAEEFGlsaAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 97 GCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLL 176
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 177 VLIGALMCVSLCWLPETLPEAKRVKAslTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHY 256
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAA--KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 257 GWLFALNIVGVMAMSVLNRRLVQRHPleqlLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAA 336
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754952400 337 ALDAVP-NIAGSASALIGALQYGSGIISSLLLAAFSD--GTPWTMAWIIALFTLLSATLALRAKR 398
Cdd:COG2223 320 VPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDatGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
18-199 |
7.74e-15 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 75.88 E-value: 7.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 18 LSFILILSGLMAFtsLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIG 94
Cdd:TIGR00711 3 LTIVLMLGTFMAV--LDSTIVNVAIPTIAGDLGSSlsqVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 95 SAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFW 174
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180
....*....|....*....|....*.
gi 754952400 175 LLVLIGALMCV-SLCWLPETLPEAKR 199
Cdd:TIGR00711 161 INVPIGIIVVVvAFFILPRDKPAASE 186
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-398 |
8.06e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.28 E-value: 8.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLSTDIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAG 97
Cdd:COG0738 10 LIAIYLLFFLWGFATALWGPLIPALKDAFGlsdAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 98 CALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTrAAQMLSTLVLIMAIAPIAGPLIGGQIIRLS---TWHAVFW 174
Cdd:COG0738 90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 175 LLVLIGALMCVSLCWLPetLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQ 254
Cdd:COG0738 169 ILAVLLLLLALLFLRSK--LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 255 HYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALlvkleSGGIVAIIITIFLLFSMNGIIAATST 334
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL-----APGPWLALIGLALVGLGLSLMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754952400 335 AAALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMA-WIIALFTLLSATLALRAKR 398
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAfLVPLVCYLLILLLALALKR 386
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-221 |
1.89e-14 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 74.29 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 36 DIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRV 112
Cdd:PRK10473 20 DMYLVGLPRIAADLNASeaqLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 113 FQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCV-SLCWLP 191
Cdd:PRK10473 100 LQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLlSLFILK 179
|
170 180 190
....*....|....*....|....*....|
gi 754952400 192 ETLPEAKRVKASLTGAfrnYRSLLSNGRFM 221
Cdd:PRK10473 180 ETRPARAPAASSKPRE---NSESLLNRFFL 206
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
20-287 |
2.45e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 70.68 E-value: 2.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 20 FILILSGLMafTSLSTDIYLPAMPTMATDLHGNVE------LTITGFLVGFTIaqLIWGPISDHLGRRKPLFIGMVLFII 93
Cdd:cd17473 2 ITLLLASTL--TVMAGAAIAPALPAIAQHFVPNSEllvpllLTLPALFIALFA--PLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 94 GSAGCALSTSITQIVFWRVFqaLGACTGPM--LARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLStWHA 171
Cdd:cd17473 78 GGVAGLFLDSLYALLASRAL--LGIGVAGImtLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 172 VFW-----LLVLIGALMCvslcwlpetLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYI 246
Cdd:cd17473 155 PFLvyllaLPVLILVLLF---------LPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQ 225
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 754952400 247 SYYHVDPQHYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLL 287
Cdd:cd17473 226 ERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-395 |
2.67e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.51 E-value: 2.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 41 AMPTMATDLHGNVE---LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFqaLG 117
Cdd:cd17319 25 AAPTIMKDLGLSPTqygLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFL--LG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 118 ACTGPM--LARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVslcwlpetlp 195
Cdd:cd17319 103 VAEAGFfpGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAV---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 196 eakrvkasltGAFRNYRsllsngRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALNIVGVMAMSVLNR 275
Cdd:cd17319 173 ----------LWWFYLR------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 276 RLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIfLLFSMNGIIAATSTAAALDAVPNIAGSASALIGAL 355
Cdd:cd17319 237 RLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSL-AGFGIGAASPVFWSLPADLLPGEAAATAGGLINSG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 754952400 356 QYGSGIISSLLLAAFSDGT-PWTMAWII-ALFTLLSATLALR 395
Cdd:cd17319 316 GNLGGFVAPLLIGYLVDATgSYTAAFLFlAAVALLAALLVLL 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-282 |
8.81e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.00 E-value: 8.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 28 MAFTSLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSI 104
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYAHDLGGSeavAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 105 TQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIgALMC 184
Cdd:cd17489 85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL-ALLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 185 VSLCWLpetLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITgspFVYISYYHVDPQHYGWLFALNI 264
Cdd:cd17489 164 LLLVFL---VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIST---FLPLYAAERGISNAGLFFTVYA 237
|
250
....*....|....*...
gi 754952400 265 VGVMAMSVLNRRLVQRHP 282
Cdd:cd17489 238 IALLLSRPFSGKLSDRKG 255
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
24-287 |
2.85e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 61.46 E-value: 2.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 24 LSGLMAFTSLSTDIYLPAMPTMATDLHGNveltiTGFLVGFTIA---------QLIWGPISDHLGRRKPLFIGMVLFIIG 94
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGA-----TPTLIGLALGiygltqaifQIPFGLLSDRIGRKPVILFGLLLFIAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 95 SAGCALSTSITQIVFWRVFQALGACTGPMLarAMIRDLFA---RTRAAQMLSTLVLI-MAIAPIAGPLIGGQIirlstwh 170
Cdd:cd17472 76 SLLAAYATSIYGLILGRALQGSGAISSVVM--ALLADLTReenRTKAMALIGASIGIaFAISMVLGPLLAAHL------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 171 AVFWLLVLIGALMCVSLCWLPETLPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYH 250
Cdd:cd17472 147 GVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGG 226
|
250 260 270
....*....|....*....|....*....|....*..
gi 754952400 251 VDPQHYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLL 287
Cdd:cd17472 227 GKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVF 263
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-390 |
8.00e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 59.90 E-value: 8.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 20 FILILSGLMAFTSLstdiyLPAMPTMATDLH--GNVELTITGFLVGFTIAQLI----WGPISDHLGRRKPLFIGMVLFII 93
Cdd:cd17330 2 FLVVFLDALGFGIV-----FPVLPFYVREFNklGASGYYVGLLQSSYSLGQFLasplWGRLSDRYGRKPVLLLSLAGSAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 94 GSAGCALSTSITQIVFWRVFQALGACTGPmLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVF 173
Cdd:cd17330 77 SYVLLGLSRNLWLLFLARFLDGLTGGNVS-VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 174 WLLVLIGALMCV-SLCWLPetlpeakrvkasltgafrnyrsllsngrFMRYTLSLTFYYVGAYAFITGSPFVYISY-YHV 251
Cdd:cd17330 156 LVAAALALLNLVlVLFFLP----------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDrFGF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 252 DPQHYGWLFALN-IVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIA 330
Cdd:cd17330 208 SPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSA 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 331 ATSTAAALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSA 390
Cdd:cd17330 288 LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-283 |
1.86e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.73 E-value: 1.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 6 QASPVATASHTGLSFILILSGLMAFTSLSTDIYL--PAMPTMATDLHgnVELTITGFL-----VGFTIAQLIWGPISDHL 78
Cdd:COG2807 3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSvgPLLPEIRADLG--LSATQAGLLttlplLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 79 GRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARtRAAQMLSTLVLIMAIAPIAGPL 158
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 159 IGGQIIRLSTWHAVFWLLVLIGALmcVSLCWLPETLPEAKRVKASLTGAfrNYRSLLSNGRFMRYTLSLTFYYVGAYAFI 238
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALL--ALLLWLPLLRRRPAAAAAAPAAA--SLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 754952400 239 TGSPFVYISyYHVDPQHYGWLFAL----NIVGVMAMSVLNRRLVQRHPL 283
Cdd:COG2807 236 AWLPPILRD-AGLSAATAGLLLSLfqlaGIPGSLLVPLLADRLGDRRPL 283
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
66-290 |
2.46e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.39 E-value: 2.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 66 IAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTL 145
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 146 VLIMAIAPIAGPLIGGQIIRLStwhavFWLLVLIGALMC-----VSLCWLPETLPeaKRVKASLTGAFRNYRSLLSNGRF 220
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLFllaalVLLFLLPETRP--KRRAAEKTEILRGYKIVLRDRAF 202
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 221 MRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALNIVGVMAMSVLNRRLVQRHPLEQLLKYA 290
Cdd:cd17329 203 LLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIG 272
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-397 |
2.60e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 58.36 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 31 TSLSTDIYLPAMPTMATDLH---GNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQI 107
Cdd:cd17504 8 VMLVETMLSPALPTIQREFGtsaAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 108 VFWRVFQALGACTGPmLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSL 187
Cdd:cd17504 88 IAGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 188 CWLPETLPEAKRVKASLTGAFrnyrsLLSNGRFMrytLSLTFYYVGAYAFITGSPFvyisyyhvDPQHYGWLFALNIVGV 267
Cdd:cd17504 167 PLIDLRLLRRRNVLLANITAL-----LAGFGMFM---VFQLLPQLLQLPTPTGFGL--------GITEAGLLLLPGALVM 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 268 MAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALLvkleSGGIVAIIITIFLLFSMNGIIAATSTAAALDAVP-NIAG 346
Cdd:cd17504 231 LIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALL----HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPpDRTG 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754952400 347 SASALIGALQY-GSGI---ISSLLLAAFSDGTPW----------TMAWIIALFTLLSATLALRAK 397
Cdd:cd17504 307 IATGMNTVLRTiGSAIgpaIAGAILTTYTVSITSggvptegayvLAFLIGAALALAALLLSLLIP 371
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
61-194 |
4.16e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.75 E-value: 4.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 61 LVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGacTGPMLARAMIrdLFARTRAAQ 140
Cdd:TIGR00895 62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG--LGGLMPNLNA--LVSEYAPKR 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 754952400 141 MLSTLVLIM----AIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLC-WLPETL 194
Cdd:TIGR00895 138 FRGTAVGLMfcgyPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrFLPESI 196
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
32-190 |
1.93e-08 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 55.89 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 32 SLSTDIYLPAMPTMATDLhGNVELTITGFLVGFTIAQLIWGPIS----DHLGRRKPLFIGMVLFIIGSAGCALSTSITQI 107
Cdd:PRK10504 23 SLDTTIVNTALPSMAQSL-GESPLHMHMVIVSYVLTVAVMLPASgwlaDRVGVRNIFFTAIVLFTLGSLFCALSGTLNEL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 108 VFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSL 187
Cdd:PRK10504 102 LLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIAT 181
|
...
gi 754952400 188 CWL 190
Cdd:PRK10504 182 LML 184
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
61-175 |
3.70e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.51 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 61 LVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQ 140
Cdd:cd17365 44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123
|
90 100 110
....*....|....*....|....*....|....*
gi 754952400 141 MLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWL 175
Cdd:cd17365 124 AVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
29-394 |
5.24e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 5.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 29 AFTSLSTDIYLPAMPTMATDLHGN---VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSIT 105
Cdd:cd06173 9 LLSALGDWIFTVALPWLVLQLTGSallVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 106 QIVFWRVF--QALGACTGPM---LARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIG 180
Cdd:cd06173 89 SLSLWLLLvlAFLLGIASAFfgpARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 181 ALMCVSLCWLPETLPEAKRVKASL-TGAFRNYRSLLSNGRFMRYTL-SLTFYYVGAYAFITGSPFVYISYYHVDPQHYGW 258
Cdd:cd06173 169 LLSALLLLFIRRPPPAAPGESSSLlLRDLREGLRYLRRSPLLRLLLlALALFALLGGALTVLLPLLAKEVLGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 259 LFALNIVGVMAMSVLNRRLVQRHPLEQLLKYATMLAALAAVALALlvkleSGGIVAIIITIFLLFSMNGIIAATSTAAAL 338
Cdd:cd06173 249 LLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 754952400 339 DAVPN-IAGSASALIGALQYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSATLAL 394
Cdd:cd06173 324 LRVPDeLRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
58-253 |
8.68e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.78 E-value: 8.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 58 TGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTR 137
Cdd:cd17328 41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 138 AAQMLSTLVLIMAIAPIAGPLIGGQIIRLS-TWHAVFWLLVLIGALMCVSLCWLPETLP-----EAKRVKASLTGAFRNY 211
Cdd:cd17328 121 RTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPrgaaeGGVMAKSTATSFLADL 200
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 754952400 212 RSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDP 253
Cdd:cd17328 201 KALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGD 242
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
41-394 |
1.18e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.99 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 41 AMPTMATDLHGNVELTITGFLVGFT-----IAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQA 115
Cdd:cd17316 21 VAPVLAAEFSLGLSLLQTGLLFAAGflgrpIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 116 LGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLCWLpetlp 195
Cdd:cd17316 101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 196 eakrvkasltgafrnyrsllsNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALNIVGVMAMSVLNR 275
Cdd:cd17316 176 ---------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 276 RLVQRhpLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAAALDAVPNIAGSASALIGAL 355
Cdd:cd17316 235 LLSDR--IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNL 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 754952400 356 QYGSGIISSLLLAAFSDGTPWTMAWIIALFTLLSATLAL 394
Cdd:cd17316 313 GRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-198 |
2.10e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.58 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 23 ILSGLMAFTSLSTDIYLPAMPTMATDLHGNVELTITGFLVGFTI----AQLIWGPISDHLGRRKPLFIGMVLFIIGSAGC 98
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALlgalGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQIVFWrVFQALGACTGPMLAR--AMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLS-TWHAVFWL 175
Cdd:COG2223 289 ALALGSLWLFLV-LFLLLGLALGGGNGAvfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLV 367
|
170 180
....*....|....*....|...
gi 754952400 176 LVLIGALMCVSLCWLPETLPEAK 198
Cdd:COG2223 368 FAVLALVALVLTLLLYRRPRRAA 390
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
66-280 |
2.43e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 66 IAQLIWGPISDHL----GRRKP-LFIGMVLFIIGSAGCALSTSITQ--------IVFWRVFQALGACTGP--MLARAMIR 130
Cdd:COG2211 61 ITDPLIGALSDRTrtrwGRRRPwILIGAIPLALSFVLLFTAPDLSPtgkliyalVTYLLLGLAYTLVNIPysALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 131 DLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLCWLPETLPEAKRVKASLTGAFRN 210
Cdd:COG2211 141 DYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES 220
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 211 YRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALNIVGVMAMSVLNRRLVQR 280
Cdd:COG2211 221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
55-379 |
8.99e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.45 E-value: 8.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 55 LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFA 134
Cdd:TIGR00881 34 LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 135 RTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLS-TWHAVFWLLVLIGALMCVSLCWL------------------PETLP 195
Cdd:TIGR00881 114 RSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSLICFLLlrdspqscglppaeempnEEPDG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 196 EAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFAL----NIVGVMAMS 271
Cdd:TIGR00881 194 DAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLyelgGLVGTLLAG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 272 VLNRRLV--QRHPLEQLlkyatMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAAALDAVPNIAGSAS 349
Cdd:TIGR00881 274 WLSDKLFngRRGPLAVF-----FMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAA 348
|
330 340 350
....*....|....*....|....*....|
gi 754952400 350 ALIGALQYGSGIISSLLLAAFSDGTPWTMA 379
Cdd:TIGR00881 349 GFVGFFAYLGGILAGLPLGYLADGFGWAGA 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
58-395 |
9.79e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.35 E-value: 9.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 58 TGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTR 137
Cdd:cd17312 45 SAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 138 AAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLCWLpetlpeakrvkasltgaFRNyrsllSN 217
Cdd:cd17312 125 RGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF-----------------LRD-----SP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 218 GRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALN----IVGVMAMSVLNRRLVQRHPLEQLLKYATML 293
Cdd:cd17312 183 PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYevggIAGTILAGLLSDKLFGGRRAPIAVIYMLLM 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 294 AALAAVALALLVKLEsggIVAIIITIFLLFSMNGIIAATSTAAALDAVPNIAGSASALIGALQYGSGIISSLLLAAFSDG 373
Cdd:cd17312 263 TLSLALFWFFPHNKL---LSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDH 339
|
330 340
....*....|....*....|...
gi 754952400 374 TPW-TMAWIIALFTLLSATLALR 395
Cdd:cd17312 340 YGWsTVFYFLISAALLSVLLLLS 362
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
55-196 |
1.46e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 55 LTITGFLVGFTIAQLIWGPISDHLGRRK--PLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDL 132
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754952400 133 FARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLCWLPETLPE 196
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
55-193 |
1.74e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 49.49 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 55 LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALG----ACTGPM----LAR 126
Cdd:cd17359 40 LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvggaSALVPMyiaeVAP 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754952400 127 AMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLCWLPET 193
Cdd:cd17359 120 AEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPES 186
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
21-183 |
1.89e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.93 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 21 ILILSGLMAFTSLStdiylPAMPTMATDLHG--NVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGC 98
Cdd:cd06179 5 LAYFAQLFGVTLPA-----AVLPFIVADLGPssNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQIVFWRVFQALGACTGPMLArAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIR--LSTWHAVFWLL 176
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGA-AVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYIN 158
|
....*..
gi 754952400 177 VLIGALM 183
Cdd:cd06179 159 AIFNALA 165
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
60-206 |
1.98e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.58 E-value: 1.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 60 FLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALST---SITQIVFWRVFQALGA----CTGPMLARAMirdl 132
Cdd:pfam00083 55 FSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVggasVLAPMYISEI---- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 133 fARTRAAQMLSTLVLIMaiapIAGPLIGGQIIRLST--------WHAVFWLLVLIGALMCVSLCWLPET---------LP 195
Cdd:pfam00083 131 -APKKLRGALGSLYQLA----ITFGILLAYIFGLGLnktsnsdgWRIPLGLQLVPALLLIIGLLFLPESprwlvekgrLE 205
|
170
....*....|.
gi 754952400 196 EAKRVKASLTG 206
Cdd:pfam00083 206 EAREVLAKLRG 216
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
24-262 |
2.19e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 24 LSGLMAFTSLSTDIYLPAMPTMATDLHGNVELTITGFLVGFTIAQLI----WGPISDHLGRRKPLFI-GMVLFIIGSAGC 98
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVvsqwLGRLSDRGGDRKPLILlALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQ-IVFWRVFQALGACTGPMLArAMIRDLFAR---TRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFW 174
Cdd:cd17471 81 AFLRNYWVlLLVGVVLLSLGAAAFPQLF-ALAREYADRssgRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 175 LLVLIGALMCVSLCWLpetLPEAKRVKASLTGAFRNyRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQ 254
Cdd:cd17471 160 LAALLYLVVALLVLFL---LPSVKPPAQKATPASSL-VKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSES 235
|
....*...
gi 754952400 255 HYGWLFAL 262
Cdd:cd17471 236 WVGLLFGL 243
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
55-235 |
9.34e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.30 E-value: 9.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 55 LTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFA 134
Cdd:cd17371 38 LLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 135 RTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLST----WHAVFWlLVLIGALMCVSL-CWLPETlPEAKRVKASL-TGAF 208
Cdd:cd17371 118 ARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFL-LGALPALLVLFIrRFVKEP-PQWQAARAARrHFAD 195
|
170 180
....*....|....*....|....*..
gi 754952400 209 RNYRSLLSNGRFMRYTLSLTFYYVGAY 235
Cdd:cd17371 196 RPSLRELFSPPLLRTTLLASLLATGAL 222
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-117 |
5.88e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.01 E-value: 5.88e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754952400 53 VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALG 117
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMG 193
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
22-185 |
8.59e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.18 E-value: 8.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 22 LILSGLMAFTSLSTDIYLPAMPTMATDL---HGNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGC 98
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFgtsPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 99 ALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQMLSTLVLIMA-IAPIAGPLIGGQIIRLSTWHAVFWLLV 177
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATApLGFALGGVFGGLFAQLAWWPWIFWFLA 160
|
....*...
gi 754952400 178 LIGALMCV 185
Cdd:cd17476 161 ILAAIVAV 168
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
53-120 |
2.49e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.57 E-value: 2.49e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754952400 53 VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACT 120
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAG 94
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
43-395 |
3.83e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 43 PTMATDLHgnVELTITGFLVGF-----TIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQ-AL 116
Cdd:cd17475 20 PFLQEDLH--LSLAQVGLLLSAlnlgvAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVgAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 117 GACTGPMLARAMIRDLFARTRAAQM---LSTLVLIMAIAPIAGPLIGGQIirlsTWHAVFWLLVLIGALMCV-SLCWLPE 192
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMgirQTGVPLGGALAAALLPPLALHY----GWRAAFVVAGLVSILAAVlFWLFYRE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 193 TlPEAKRVKASLTGAFRNYRSLLSNGRFMRYTLSLTFYYVGAYAFITGSPFVYISYYHVDPQHYGWLFALNIVGVMAMSV 272
Cdd:cd17475 174 P-PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 273 LNRRLVQRHPLEQLLKYATMLAALAAVALALLVKLESGGIVAIIITIFLLFSMNGIIAATSTAAALDAV--PNIAGSASA 350
Cdd:cd17475 253 GLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESagPEQAGTALG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 754952400 351 LIGALQYGSGIISSLLLAAFSDGT-PWTMAWIIALFTLLSATLALR 395
Cdd:cd17475 333 LANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
29-252 |
4.46e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 29 AFTSLSTDIYLPAMPTMATDLHGNVELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIV 108
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 109 FWRVFQALGACTGPMLARAMIRDLFARTRAAqMLSTLVLIMAIAPIAGPLIGGQII-RLSTWHAVFWLLVLIGALmcVSL 187
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALFEESSAT-RLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLL--LAI 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754952400 188 CWLPETLPEAKRVKASLTGAFRNYRSLLSN--GRFMRYTLSLTFYYVGA-YAFITGSPFVYISYYHVD 252
Cdd:cd17333 166 LILLTLFPELPSARNPQQSVGAFSASASRLlrNPSIILGALALFLYVGAeTAFSSWVPSYLVEKKHVS 233
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-187 |
6.59e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 6.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 57 ITGFLVGFTIAQLIWGPISDHLGRRKpLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPM--LARAMIRDLFA 134
Cdd:cd17477 229 LAAFVLGGLLLQWPLGWLADRFDRRR-VLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLytLALALAGDRLP 307
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 754952400 135 RTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSL 187
Cdd:cd17477 308 GDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
60-112 |
7.25e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.41 E-value: 7.25e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 754952400 60 FLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRV 112
Cdd:cd17315 43 LLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
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|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
37-221 |
7.56e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.44 E-value: 7.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 37 IYLPAMPTMATDLhgNVELTITGFLVG-FTIAQLIW----GPISDHLGRRKP-LFIGMVLFIIGSAGCALSTSITQIVFW 110
Cdd:cd17490 14 VYVPFLSPYAESL--GASLSMIGIILGaYGISQMLLriplGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 111 RVFQALGACTGPMLArAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLLVLIGALMCVSLCWL 190
Cdd:cd17490 92 RFLSGIAAATWVSFT-VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170
|
170 180 190
....*....|....*....|....*....|.
gi 754952400 191 PETLPEAKRVKASLtgafRNYRSLLSNGRFM 221
Cdd:cd17490 171 KEERREKKPVLTEL----KELLSVLKDKKLL 197
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|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
53-193 |
1.90e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.95 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 53 VELTITGFLVGFTIAqliwGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDL 132
Cdd:cd17360 41 VSSTVAGAAVGAAIG----GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEA 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 754952400 133 FARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRL-STWHAVFWLLVLIGALMCVSLCWLPET 193
Cdd:cd17360 117 APPRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLGLAAVPAVLQFIGLLFLPES 178
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
72-179 |
2.62e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 39.71 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 72 GPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIRDLFARTRAAQM-LSTLVLIMA 150
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMaLGVWAAVGS 141
|
90 100
....*....|....*....|....*....
gi 754952400 151 IAPIAGPLIGGQIIRLSTWHAVFWLLVLI 179
Cdd:PRK14995 142 GGAAFGPLVGGILLEHFYWGSVFLINVPI 170
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
53-205 |
3.84e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.26 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 53 VELTITGFLVGFTIAQLIWGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVFQALGACTGPMLARAMIrdl 132
Cdd:cd17362 41 SGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYI--- 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754952400 133 fARTRAAQMLSTLVLIMAIAPIAGPLIG-----GQIIRLSTWHAVFWLLVLIGALMCVSLCWLPETLPEAKRVKASLT 205
Cdd:cd17362 118 -AETSPSHIRGLLVSLKELFIVLGILLGyvsgyAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQGNYRKPLI 194
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|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
50-232 |
4.75e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 39.02 E-value: 4.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 50 HGNVELTITGFLVGFTIAQLIwGPISDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFW----RVFQALGACTGPMLA 125
Cdd:cd17449 65 HWNLYINLGGFLVGLFSVTLL-GPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYfligRILSGLLGDFNGILA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 126 R--AMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGQIIRLSTWHAVFWLL--VLIGALMCVSLCwLPETLPEAKRVK 201
Cdd:cd17449 144 GcfAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVlaLNLAAALYAAFC-VGESVKEPKSAR 222
|
170 180 190
....*....|....*....|....*....|....*.
gi 754952400 202 ASLTGAFRNYRSLLS-----NGRFMRYTLSLTFYYV 232
Cdd:cd17449 223 LFTTRHHQSVVRLYVapapnGSRRKLALYSLALFVV 258
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
39-183 |
8.26e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 37.98 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 39 LPAMPTMATDLHGNVelTITGFLVG-FTIAQLIWGPI----SDHLGRRKPLFIGMVLFIIGSAGCALSTSITQIVFWRVF 113
Cdd:cd17390 16 LPLLSTHIRSLGASP--TVIGLIGSvYGALQLFSSPLvgswSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIP 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754952400 114 QALGACTgPMLARAMIRDLFARTRAAQMLSTLVLIMAIAPIAGPLIGGqiiRLSTWHAVFWLLVLIGALM 183
Cdd:cd17390 94 LGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGG---HLAETDGGFYYVALLCSAI 159
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