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Conserved domains on  [gi|755118890|ref|WP_042469298|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Sphingomonadaceae]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
18-102 1.42e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 1.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755118890  18 QVADTLKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLLGT 97
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEW 87


                 ....*
gi 755118890  98 LYQLY 102
Cdd:COG0640   88 LLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
18-102 1.42e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 1.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755118890  18 QVADTLKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLLGT 97
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEW 87


                 ....*
gi 755118890  98 LYQLY 102
Cdd:COG0640   88 LLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 19-95 2.18e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.90  E-value: 2.18e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755118890  19 VADTLKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLL 95
Cdd:NF033788   1 LAELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-90 1.34e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 1.34e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755118890  23 LKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADAR 90
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
37-98 1.45e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 70.32  E-value: 1.45e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755118890    37 KLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLLGTL 98
Cdd:smart00418   4 KLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 31-73 2.39e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.60  E-value: 2.39e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755118890   31 RLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLV 73
Cdd:pfam01022   4 RLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 30-74 4.06e-05

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 40.42  E-value: 4.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755118890   30 RRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVT 74
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 24-84 2.64e-04

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 37.49  E-value: 2.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755118890  24 KAIGNARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWY 84
Cdd:PRK10141  11 KILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
18-102 1.42e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 1.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755118890  18 QVADTLKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLLGT 97
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEW 87


                 ....*
gi 755118890  98 LYQLY 102
Cdd:COG0640   88 LLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 19-95 2.18e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.90  E-value: 2.18e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755118890  19 VADTLKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLL 95
Cdd:NF033788   1 LAELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-90 1.34e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 1.34e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755118890  23 LKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADAR 90
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
37-98 1.45e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 70.32  E-value: 1.45e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755118890    37 KLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIADARVETLLGTL 98
Cdd:smart00418   4 KLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 31-73 2.39e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.60  E-value: 2.39e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755118890   31 RLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLV 73
Cdd:pfam01022   4 RLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
14-92 3.56e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 55.04  E-value: 3.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755118890  14 AKAGQVADTLKAIGNARRLMLLCKLVEhGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTL-----WYAIAD 88
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDgrarkYYRLSA 80


                 ....
gi 755118890  89 ARVE 92
Cdd:COG1777   81 FRLE 84
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 20-78 1.49e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 49.46  E-value: 1.49e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755118890   20 ADTLKAIGNARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRE 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
20-88 1.76e-08

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 47.65  E-value: 1.76e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755118890  20 ADTLKAIGNARRLMLLcKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVT-----YRRESQTLWYAIAD 88
Cdd:COG4189   10 LEVLKALASETRLRIL-RLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRteykpGKRGRQKICYLRVD 82
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
29-88 1.89e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 49.11  E-value: 1.89e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755118890  29 ARRLMLLckLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIAD 88
Cdd:COG3398   99 PRRILLY--LLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
31-73 4.93e-07

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 42.81  E-value: 4.93e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755118890   31 RLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLV 73
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 38-88 1.42e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.59  E-value: 1.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755118890  38 LVEH-GEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIAD 88
Cdd:COG2512   24 LRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPE 75
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
38-81 1.98e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 44.14  E-value: 1.98e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 755118890  38 LVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQT 81
Cdd:COG2345   22 LKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRG 65
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-77 5.60e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.26  E-value: 5.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 755118890   38 LVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:pfam12802  14 LARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
18-77 9.43e-06

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 41.49  E-value: 9.43e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755118890  18 QVADTLKAIG-NARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:COG1846   26 ALDRALAELGlTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
38-74 1.47e-05

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 40.92  E-value: 1.47e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755118890  38 LVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVT 74
Cdd:COG1522   14 LQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 38-74 3.28e-05

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 39.42  E-value: 3.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755118890    38 LVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVT 74
Cdd:smart00344  12 LQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 22-74 3.60e-05

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 40.44  E-value: 3.60e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755118890  22 TLKAIGNARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVT 74
Cdd:cd09655  132 PLLAGLSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVE 184
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 30-74 4.06e-05

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 40.42  E-value: 4.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755118890   30 RRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVT 74
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-77 4.16e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 39.11  E-value: 4.16e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 755118890    28 NARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:smart00347   9 TPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP 58
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 37-86 9.21e-05

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 37.50  E-value: 9.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 755118890   37 KLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAI 86
Cdd:pfam01978  16 ALLKLGPATADEIAEESGVPRSKVYEVLRSLEDKGLVEREKGRPKKYRAV 65
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-77 1.33e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.76  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 755118890   28 NARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:pfam01047   2 TLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSR 51
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
21-77 2.05e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.88  E-value: 2.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755118890  21 DTLKAIgnarrlmllCKLVE-HGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:COG1321   10 DYLKAI---------YELSEeGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEP 58
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 24-84 2.64e-04

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 37.49  E-value: 2.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755118890  24 KAIGNARRLMLLCKLVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWY 84
Cdd:PRK10141  11 KILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
38-98 3.96e-04

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 37.69  E-value: 3.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755118890  38 LVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQTLWYAIAdarVETLLGTL 98
Cdd:COG1378   22 LLELGPATASELAKASGVPRSRVYDVLESLEEKGLVEVSEGRPKRYRAVP---PEEALERL 79
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
38-68 1.56e-03

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 33.50  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755118890   38 LVEHGEMTVGDLARDVGLSQSACSQHLARMR 68
Cdd:pfam13404  11 LQEDARISFAELAERVGLSESTVLRRIRRLE 41
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
40-81 2.39e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 35.57  E-value: 2.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 755118890  40 EHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRESQT 81
Cdd:COG1414   21 AGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGR 62
DmsR COG3413
Predicted transcriptional regulator, contains HTH domain [General function prediction only];
39-66 3.05e-03

Predicted transcriptional regulator, contains HTH domain [General function prediction only];


Pssm-ID: 442639 [Multi-domain]  Cd Length: 143  Bit Score: 34.91  E-value: 3.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755118890  39 VEHG------EMTVGDLARDVGLSQSACSQHLAR 66
Cdd:COG3413   98 YEMGyfevprEATLEELAEELGISKSTLSEHLRR 131
TFIIE_alpha pfam02002
TFIIE alpha subunit; The general transcription factor TFIIE has an essential role in ...
 38-84 4.42e-03

TFIIE alpha subunit; The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits TFIIE-alpha and TFIIE-beta and joins the pre-initiation complex after RNA polymerase II and TFIIF. This family consists of the conserved amino terminal region of eukaryotic TFIIE-alpha and proteins from archaebacteria that are presumed to be TFIIE-alpha subunits also Swiss:O29501.


Pssm-ID: 280224  Cd Length: 105  Bit Score: 33.91  E-value: 4.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 755118890   38 LVEHGEMTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR--ESQTLWY 84
Cdd:pfam02002  22 LLFNGEVTEEDLAELLKIDLNELRKLLNRLYEARLISYRRrrDDETGWY 70
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 29-77 4.53e-03

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 34.58  E-value: 4.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755118890  29 ARRLMLLCKLVEHGE------MTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:COG0664  138 ERLARFLLELADRLDgridlpLTQEEIASYLGLTRETVSRILKKLEKEGLIELER 192
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
37-78 8.21e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 33.40  E-value: 8.21e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 755118890  37 KLVEHGE-MTVGDLARDVGLSQSACSQHLARMRDEGLVTYRRE 78
Cdd:COG3355   35 ILLENGEpLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKR 77
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 29-77 8.77e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 32.43  E-value: 8.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755118890   29 ARRLMLLCKLVEHGE----MTVGDLARDVGLSQSACSQHLARMRDEGLVTYRR 77
Cdd:pfam13545   4 ARFLLELAARDGGGRidlpLTQEDLADLLGTTRETVSRVLSELRREGLIERGR 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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