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Conserved domains on  [gi|757138459|ref|WP_042692707|]
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Asp-tRNA(Asn) amidotransferase subunit GatC [Methanobrevibacter oralis]

Protein Classification

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC( domain architecture ID 1369)

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC is part of a heterotrimeric complex that forms correctly charged Gln-tRNA(Gln) or Asn-tRNA(Asn) through the transamidation of misacylated Glu-tRNA(Gln) or Asp-tRNA(Asn)

CATH:  1.10.20.60
EC:  6.3.5.-
Gene Ontology:  GO:0006450|GO:0050567|GO:0005524
SCOP:  3001870

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gatC super family cl00495
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC;
3-70 3.59e-17

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC;


The actual alignment was detected with superfamily member TIGR01827:

Pssm-ID: 469792  Cd Length: 73  Bit Score: 68.05  E-value: 3.59e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757138459   3 IEKDAEEIIDKFSKTLENIPDLEETWYITDNLNLTRDDESHEKNPE---KILRNARIDKDGNLIVKKADWT 70
Cdd:TIGR01827  2 ILKEAEEILEEFSERLEDVDEEEETYYISDGSNKFREDEEPRCDPEfkkKMLENAPVSDDGYVVVERGHWL 72
 
Name Accession Description Interval E-value
gatC_rel TIGR01827
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase, subunit C, putative; This model represents a ...
 3-70 3.59e-17

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase, subunit C, putative; This model represents a family small family related to GatC, the third subunit of an enzyme for completing the charging of tRNA(Gln) by amidating the Glu-tRNA(Gln). The few known archaea that contain a member of this family appear to produce Asn-tRNA(Asn) by an analogous amidotransferase reaction. This protein is proposed to substitute for GatC in the charging of both tRNAs.


Pssm-ID: 130886  Cd Length: 73  Bit Score: 68.05  E-value: 3.59e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757138459   3 IEKDAEEIIDKFSKTLENIPDLEETWYITDNLNLTRDDESHEKNPE---KILRNARIDKDGNLIVKKADWT 70
Cdd:TIGR01827  2 ILKEAEEILEEFSERLEDVDEEEETYYISDGSNKFREDEEPRCDPEfkkKMLENAPVSDDGYVVVERGHWL 72
gatC PRK00034
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC;
3-66 4.18e-07

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC;


Pssm-ID: 178810 [Multi-domain]  Cd Length: 95  Bit Score: 42.88  E-value: 4.18e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757138459  3 IEKDAEEIIDKFSKTLENIPDLEE--------TWYITDNLNLTRDDESHEKN-PEKILRNARIDKDGNLIVKK 66
Cdd:PRK00034 20 SEEELEKFAGQLNKILDFVEQLNEvdtegvepTTHPLDMKNVLREDVVTESLpREEALKNAPESEDGYFKVPK 92
 
Name Accession Description Interval E-value
gatC_rel TIGR01827
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase, subunit C, putative; This model represents a ...
 3-70 3.59e-17

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase, subunit C, putative; This model represents a family small family related to GatC, the third subunit of an enzyme for completing the charging of tRNA(Gln) by amidating the Glu-tRNA(Gln). The few known archaea that contain a member of this family appear to produce Asn-tRNA(Asn) by an analogous amidotransferase reaction. This protein is proposed to substitute for GatC in the charging of both tRNAs.


Pssm-ID: 130886  Cd Length: 73  Bit Score: 68.05  E-value: 3.59e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757138459   3 IEKDAEEIIDKFSKTLENIPDLEETWYITDNLNLTRDDESHEKNPE---KILRNARIDKDGNLIVKKADWT 70
Cdd:TIGR01827  2 ILKEAEEILEEFSERLEDVDEEEETYYISDGSNKFREDEEPRCDPEfkkKMLENAPVSDDGYVVVERGHWL 72
gatC PRK00034
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC;
3-66 4.18e-07

Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC;


Pssm-ID: 178810 [Multi-domain]  Cd Length: 95  Bit Score: 42.88  E-value: 4.18e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757138459  3 IEKDAEEIIDKFSKTLENIPDLEE--------TWYITDNLNLTRDDESHEKN-PEKILRNARIDKDGNLIVKK 66
Cdd:PRK00034 20 SEEELEKFAGQLNKILDFVEQLNEvdtegvepTTHPLDMKNVLREDVVTESLpREEALKNAPESEDGYFKVPK 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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