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Conserved domains on  [gi|757596211|ref|WP_042844101|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Providencia]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 18527266)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator containing a cupin-like domain, controls the expression of genes involved in stress response

Gene Ontology:  GO:0003677
PubMed:  10473770|15808743|10556324

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
9-78 2.72e-17

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 72.72  E-value: 2.72e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211   9 ELISKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIEEKQDAVT 78
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELP 75
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
103-182 2.15e-10

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


:

Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 55.24  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211 103 APNDSRRDIYTVIAQPGRDriSEPHMHGVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:COG1917   17 ADGEDELEVVRVTFEPGAR--TPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVV 94
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
9-78 2.72e-17

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 72.72  E-value: 2.72e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211   9 ELISKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIEEKQDAVT 78
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELP 75
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-69 1.80e-14

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 64.50  E-value: 1.80e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 757596211  12 SKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARL 69
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-69 3.23e-13

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 61.38  E-value: 3.23e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 757596211    15 LARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARL 69
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-69 3.80e-13

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 61.02  E-value: 3.80e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 757596211   15 LARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARL 69
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
103-182 2.15e-10

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 55.24  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211 103 APNDSRRDIYTVIAQPGRDriSEPHMHGVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:COG1917   17 ADGEDELEVVRVTFEPGAR--TPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVV 94
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 94-172 6.28e-09

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 50.97  E-value: 6.28e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757596211  94 NYLAFLLSSAPNDSRRDIYTVIAQPGRDRiSEPHMHGVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRAL 172
Cdd:cd02209    1 GYTYELLSPGLPGRKMEPFLVTLPPGGSG-GEPYSHEGEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRNP 78
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 15-71 1.40e-07

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 48.21  E-value: 1.40e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 757596211  15 LARERqknGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIE 71
Cdd:PRK13890  13 LLDER---HMTKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETPLPLLLE 66
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 117-182 1.79e-05

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 41.09  E-value: 1.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757596211  117 QPGRDriSEPHMH-GVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:pfam07883   6 PPGES--SPPHRHpGEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRNTGDEPARLLDV 70
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
9-78 2.72e-17

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 72.72  E-value: 2.72e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211   9 ELISKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIEEKQDAVT 78
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELP 75
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-69 1.80e-14

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 64.50  E-value: 1.80e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 757596211  12 SKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARL 69
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-69 3.23e-13

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 61.38  E-value: 3.23e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 757596211    15 LARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARL 69
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-69 3.80e-13

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 61.02  E-value: 3.80e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 757596211   15 LARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARL 69
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
9-74 1.38e-12

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 59.86  E-value: 1.38e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757596211   9 ELISKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIEEKQ 74
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLEE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 9-67 1.63e-10

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 54.56  E-value: 1.63e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757596211   9 ELISKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFA 67
Cdd:COG1813   11 EDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLA 69
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
103-182 2.15e-10

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 55.24  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211 103 APNDSRRDIYTVIAQPGRDriSEPHMHGVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:COG1917   17 ADGEDELEVVRVTFEPGAR--TPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVV 94
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 7-84 1.95e-09

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 52.33  E-value: 1.95e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757596211   7 PIELISKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALcvaldipfARLIEEKQDAVTVIRHGE 84
Cdd:COG3620   14 PDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKI--------AEALGKELSAVLVVDDGK 83
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 94-172 6.28e-09

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 50.97  E-value: 6.28e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757596211  94 NYLAFLLSSAPNDSRRDIYTVIAQPGRDRiSEPHMHGVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRAL 172
Cdd:cd02209    1 GYTYELLSPGLPGRKMEPFLVTLPPGGSG-GEPYSHEGEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRNP 78
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
11-71 4.14e-08

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 48.22  E-value: 4.14e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757596211  11 ISKALARERQKNGLSLSELSRKAGIAKSTLSQLESG-SGNPSIETLWALCVALDIPFARLIE 71
Cdd:COG3655    2 IYVKLDELLAERGMTKKELAEATGISRATLSRLKNGkAKAVRLDTLEKICKALDCQPGDLLE 63
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 15-71 1.40e-07

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 48.21  E-value: 1.40e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 757596211  15 LARERqknGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIE 71
Cdd:PRK13890  13 LLDER---HMTKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETPLPLLLE 66
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 20-75 1.67e-07

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 46.38  E-value: 1.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 757596211   20 QKNGLSLSELSRKAGIAKSTLSQLESG-SGNPSIETLWALCVALDIPFARLIEEKQD 75
Cdd:pfam13443   7 ADRGISKSDLARATGISRATLSRLRKGkPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 15-65 9.34e-07

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 44.44  E-value: 9.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 757596211   15 LARERQKNGLSLSELSRKAGIAKSTLSQLESGS-GNPSIETLWALCVALDIP 65
Cdd:pfam13560   6 LRRLRERAGLSQEALARRLGVSRSTLSRLETGRrGRPSPAVVERLARALGVD 57
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 13-70 9.75e-07

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 44.20  E-value: 9.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 757596211   13 KALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLI 70
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLL 59
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 19-72 1.75e-06

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 46.87  E-value: 1.75e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 757596211  19 RQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIEE 72
Cdd:PRK08154  37 RARRGMSRKVLAQASGVSERYLAQLESGQGNVSILLLRRVARALGCSLADLLGD 90
PRK04140 PRK04140
transcriptional regulator;
12-71 6.34e-06

transcriptional regulator;


Pssm-ID: 235224 [Multi-domain]  Cd Length: 317  Bit Score: 45.23  E-value: 6.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211  12 SKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIE 71
Cdd:PRK04140 128 GDVLREAREELGLSLGELASELGVSRRTISKYENGGMNASIEVAIKLEEILDVPLTKPID 187
cupin_HP0902-like cd02230
Helicobacter pylori HP0902 and related proteins, cupin domain; This family includes ...
 129-182 7.85e-06

Helicobacter pylori HP0902 and related proteins, cupin domain; This family includes prokaryotic and archaeal proteins homologous to HP0902, a functionally uncharacterized protein from Helicobacter pylori and Spy1581, a protein of unknown function from Streptococcus pyogenes. These proteins demonstrate all-beta cupin folds that cannot bind metal ions due to the absence of a metal-binding histidine that is conserved in many metallo-cupins. HP0902 is able to bind bacterial endotoxin lipopolysaccharides (LPS) through its surface-exposed loops, where metal-binding sites are usually found in other metallo-cupins, and thus may have a putative role in H. pylori pathogenicity.


Pssm-ID: 380358 [Multi-domain]  Cd Length: 83  Bit Score: 42.50  E-value: 7.85e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757596211 129 HGVSEH-------IIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:cd02230   22 QELSEHtapgdatVQVLEGEAEFTIGGETVTLKAGELIVMPANVPHALKAEEDFKMLLTLI 82
PRK09726 PRK09726
type II toxin-antitoxin system antitoxin HipB;
7-74 8.45e-06

type II toxin-antitoxin system antitoxin HipB;


Pssm-ID: 182049  Cd Length: 88  Bit Score: 42.66  E-value: 8.45e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757596211   7 PIELiSKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLIEEKQ 74
Cdd:PRK09726  10 PTQL-ANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNA 76
COG1395 COG1395
Predicted transcriptional regulator [Transcription];
12-54 1.23e-05

Predicted transcriptional regulator [Transcription];


Pssm-ID: 441005 [Multi-domain]  Cd Length: 313  Bit Score: 44.44  E-value: 1.23e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 757596211  12 SKALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIET 54
Cdd:COG1395  129 GEKLRELREERGLSLGELASELGVSRRTISKYERGEMDASIEV 171
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
111-183 1.29e-05

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 42.44  E-value: 1.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757596211 111 IYTVIAQPGRDriSEPHMH-GVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVIE 183
Cdd:COG0662   29 VKRITVPPGAE--LSLHVHpHRDEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPLELLEVQ 100
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 117-182 1.79e-05

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 41.09  E-value: 1.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757596211  117 QPGRDriSEPHMH-GVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:pfam07883   6 PPGES--SPPHRHpGEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRNTGDEPARLLDV 70
cupin_BLR2406-like cd02210
Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain; This family includes ...
 113-182 1.67e-04

Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380340 [Multi-domain]  Cd Length: 98  Bit Score: 39.04  E-value: 1.67e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757596211 113 TVIAQPGRDriSEPHMHGVSEHII-IMAGRALV--GP-LDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:cd02210   15 VVTIPPGAR--TGAHHHGEHETAIyVLSGRAETryGDrLEHRAEAGPGDFIYIPPGVPHQEVNLSDDEPAVAVV 86
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
13-86 2.96e-04

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 39.78  E-value: 2.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757596211  13 KALARERQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIPFARLI--EEKQDAVTVIRHGEAL 86
Cdd:PRK09943  10 KRLSEIRQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEFFsePEKPDEPQVVINQDDL 85
cupin_DddK cd06988
Dimethylsulfoniopropionate lyase DddK and related proteins, cupin domain; This family includes ...
 112-167 1.06e-03

Dimethylsulfoniopropionate lyase DddK and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to dimethylsulfoniopropionate lyase DddK from marine bacterium Pelagibacter. DddK cleaves dimethylsulfoniopropionate (DMSP), the organic osmolyte and antioxidant produced in marine environments, and yields acrylate and the climate-active gas dimethyl sulfide (DMS). DddK contains a double-stranded beta-helical motif which utilizes various divalent metal ions as cofactors for catalytic activity; however, nickel, an abundant metal ion in marine environments, confers the highest DMSP lyase activity. Also included in this family is Plu4264, a Photorhabdus luminescens manganese-containing cupin shown to have similar metal binding site to TM1287 decarboxylase, but two very different substrate binding pockets. The Plu4264 binding pocket shows a cavity and substrate entry point more than twice as large as and more hydrophobic than TM1287, suggesting that Plu4264 accepts a substrate that is significantly larger than that of TM1287, a putative oxalate decarboxylase. Thus, the function of Plu4264 could be similar to that of TM1287 but with a larger, less charged substrate. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380393 [Multi-domain]  Cd Length: 76  Bit Score: 36.44  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 757596211 112 YTVIAqPGRDriSEPHMHGVSEHIIIMAGRALVGPLDNPVELKVGDYIHYPGDEPH 167
Cdd:cd06988    6 WCVVR-PGTT--STPHSHHEYEIFIVISGKGIVVVDGEREPVKAGDVVYIPPGTEH 58
cupin_DRT102 cd06989
Arabidopsis thaliana DRT102 and related proteins, cupin domain; This family includes bacterial ...
 124-171 1.17e-03

Arabidopsis thaliana DRT102 and related proteins, cupin domain; This family includes bacterial and eukaryotic proteins homologous to DNA-damage-repair/toleration protein DRT102 found in Arabidopsis thaliana. DRT102 may be involved in DNA repair from UV damage. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380394  Cd Length: 97  Bit Score: 36.74  E-value: 1.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 757596211 124 SEPHMHGVSEHIIIMAGRALVGPLD-----NPVELKVGDYIHYPGDEPHIMRA 171
Cdd:cd06989   31 IPPHTHPDDERVTVISGTFYLGMGDkfdeaKAKALPAGSFFTLPAGTPHFAWA 83
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
88-170 1.29e-03

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 36.92  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757596211  88 VSAEHANYLAFLLSSAPNDSRRDIYTVIAQPGrDRISEPHMHGVSEHIIIM---AGRALVGplDNPVELKVGDYIHYPGD 164
Cdd:COG3837    7 LPGPEAGRRYRRLGDALGLTRLGVNLITLPPG-ASSSPYHAHSAEEEFVYVlegELTLRIG--GEEYVLEPGDSVGFPAG 83


                 ....*.
gi 757596211 165 EPHIMR 170
Cdd:COG3837   84 VPHRLR 89
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
1-65 3.96e-03

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 34.52  E-value: 3.96e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 757596211   1 MNLPSPPIELIsKALareRQKNGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIP 65
Cdd:COG2944    1 MTKKPLTPEEI-RAL---RERLGLSQAEFAALLGVSVSTVRRWEQGRRKPSGAALKLLRLLEKHP 61
RmlC COG4101
Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];
124-182 5.60e-03

Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];


Pssm-ID: 443277  Cd Length: 146  Bit Score: 35.71  E-value: 5.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757596211 124 SEPHMHGVSEHII-IMAGRALV--GP-LDNPVELKVGDYIHYPGDEPHIMRALEPNTMAVMVI 182
Cdd:COG4101   59 AKAHHHGEHETAIyVLSGRAETryGErLEHRVVTEPGDFIFIPPGVPHQEINLSDTEPAVAVI 121
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 4-65 6.23e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 34.40  E-value: 6.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757596211   4 PSPPIELISKALARERqknGLSLSELSRKAGIAKSTLSQLESGSGNPSIETLWALCVALDIP 65
Cdd:COG3093    6 PIHPGEILREEFLEPL---GLSQTELAKALGVSRQRISEILNGKRAITADTALRLARAFGTS 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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