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Conserved domains on  [gi|757599296|ref|WP_042846942|]
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MULTISPECIES: phosphatidylglycerophosphatase A [Providencia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgpA super family cl00559
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
 9-169 4.76e-72

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


The actual alignment was detected with superfamily member PRK11068:

Pssm-ID: 469820  Cd Length: 164  Bit Score: 214.15  E-value: 4.76e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296   9 EAKKRLNMRNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGS 88
Cdd:PRK11068   3 VAKSRLKLSNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWYLLTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDHGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  89 IVWDEFIGMWITLMAIPVVDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFGIMIDDIIAAIFAYVTIWLLVWYDIMP 168
Cdd:PRK11068  83 IVWDEFIGMWITLMALPVNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFIGHHWPLG 162


                 .
gi 757599296 169 F 169
Cdd:PRK11068 163 I 163
 
Name Accession Description Interval E-value
PRK11068 PRK11068
phosphatidylglycerophosphatase A; Provisional
 9-169 4.76e-72

phosphatidylglycerophosphatase A; Provisional


Pssm-ID: 182942  Cd Length: 164  Bit Score: 214.15  E-value: 4.76e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296   9 EAKKRLNMRNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGS 88
Cdd:PRK11068   3 VAKSRLKLSNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWYLLTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDHGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  89 IVWDEFIGMWITLMAIPVVDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFGIMIDDIIAAIFAYVTIWLLVWYDIMP 168
Cdd:PRK11068  83 IVWDEFIGMWITLMALPVNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFIGHHWPLG 162


                 .
gi 757599296 169 F 169
Cdd:PRK11068 163 I 163
PgpA COG1267
Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; ...
 16-142 5.35e-57

Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; Phosphatidylglycerophosphatase A is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440878  Cd Length: 148  Bit Score: 175.29  E-value: 5.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  16 MRNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGSIVWDEFI 95
Cdd:COG1267    1 LRNPAHLLATGFGSGLSPKAPGTWGSLAALPLYLLLLGLGLWLLLLLLLLLFLIGIWACGKTERDLGVHDPGEIVIDEVV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 757599296  96 GMWITLMAIPvVDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFG 142
Cdd:COG1267   81 GMWITLLFLP-AGWLWLLAAFVLFRLFDILKPWPIRWLDRRLKGGLG 126
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
 20-142 1.36e-45

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


Pssm-ID: 133477  Cd Length: 143  Bit Score: 146.53  E-value: 1.36e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  20 WHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMP-VWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGSIVWDEFIGMW 98
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLAALPLELLLSELGkVLLELLALLLAFLLGIWAAEKTLKDLGVHDPGEIVIDEVVGQW 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 757599296  99 ITLMAIPVvDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFG 142
Cdd:cd06971   81 IALLIVPF-GWLWGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLG 123
PgpA pfam04608
Phosphatidylglycerophosphatase A; This family represents a family of bacterial ...
 22-142 1.08e-29

Phosphatidylglycerophosphatase A; This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.


Pssm-ID: 461365  Cd Length: 136  Bit Score: 105.75  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296   22 LLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWS---IWVLIVAGFWIGCLICQRTSDDMKIHDHGSIVWDEFIGMW 98
Cdd:pfam04608   1 LIATLFGLGLLPFAPGTWGSLAALPLALLLVLSKPLSlilLLVALLLLFLLGIYAADKAEKDLGKKDPGEIVIDEVLGQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 757599296   99 ITLMAIpvvdyewVITAFFIFRIYDMWKPWPIRIFDRKvSGGFG 142
Cdd:pfam04608  81 IALLFL-------LLAGFVLFRFFDILKPWPISKLDRL-PGGWG 116
 
Name Accession Description Interval E-value
PRK11068 PRK11068
phosphatidylglycerophosphatase A; Provisional
 9-169 4.76e-72

phosphatidylglycerophosphatase A; Provisional


Pssm-ID: 182942  Cd Length: 164  Bit Score: 214.15  E-value: 4.76e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296   9 EAKKRLNMRNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGS 88
Cdd:PRK11068   3 VAKSRLKLSNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWYLLTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDHGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  89 IVWDEFIGMWITLMAIPVVDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFGIMIDDIIAAIFAYVTIWLLVWYDIMP 168
Cdd:PRK11068  83 IVWDEFIGMWITLMALPVNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFIGHHWPLG 162


                 .
gi 757599296 169 F 169
Cdd:PRK11068 163 I 163
PgpA COG1267
Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; ...
 16-142 5.35e-57

Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; Phosphatidylglycerophosphatase A is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440878  Cd Length: 148  Bit Score: 175.29  E-value: 5.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  16 MRNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGSIVWDEFI 95
Cdd:COG1267    1 LRNPAHLLATGFGSGLSPKAPGTWGSLAALPLYLLLLGLGLWLLLLLLLLLFLIGIWACGKTERDLGVHDPGEIVIDEVV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 757599296  96 GMWITLMAIPvVDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFG 142
Cdd:COG1267   81 GMWITLLFLP-AGWLWLLAAFVLFRLFDILKPWPIRWLDRRLKGGLG 126
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
 20-142 1.36e-45

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


Pssm-ID: 133477  Cd Length: 143  Bit Score: 146.53  E-value: 1.36e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296  20 WHLLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMP-VWSIWVLIVAGFWIGCLICQRTSDDMKIHDHGSIVWDEFIGMW 98
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLAALPLELLLSELGkVLLELLALLLAFLLGIWAAEKTLKDLGVHDPGEIVIDEVVGQW 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 757599296  99 ITLMAIPVvDYEWVITAFFIFRIYDMWKPWPIRIFDRKVSGGFG 142
Cdd:cd06971   81 IALLIVPF-GWLWGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLG 123
PgpA pfam04608
Phosphatidylglycerophosphatase A; This family represents a family of bacterial ...
 22-142 1.08e-29

Phosphatidylglycerophosphatase A; This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.


Pssm-ID: 461365  Cd Length: 136  Bit Score: 105.75  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599296   22 LLATGFGSGLSPIVPGTMGSLAAIPFWLLMANMPVWS---IWVLIVAGFWIGCLICQRTSDDMKIHDHGSIVWDEFIGMW 98
Cdd:pfam04608   1 LIATLFGLGLLPFAPGTWGSLAALPLALLLVLSKPLSlilLLVALLLLFLLGIYAADKAEKDLGKKDPGEIVIDEVLGQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 757599296   99 ITLMAIpvvdyewVITAFFIFRIYDMWKPWPIRIFDRKvSGGFG 142
Cdd:pfam04608  81 IALLFL-------LLAGFVLFRFFDILKPWPISKLDRL-PGGWG 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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