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Conserved domains on  [gi|757642171|ref|WP_042881692|]
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MULTISPECIES: Tfp pilus assembly protein FimT/FimU [Aeromonas]

Protein Classification

Tfp pilus assembly protein FimT/FimU( domain architecture ID 11471961)

Tfp pilus assembly protein FimT/FimU

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-61 5.89e-12

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


:

Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 57.55  E-value: 5.89e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVPKWLgkGGFETHTLR---DELVARLRLVQTMNMQEGE 61
Cdd:COG4970    5 RRRQRGFTLIELLVVLAILAILAAIAVPSFS--SLIARQRLRaaaNELAAALRLARSEAIRRGQ 66
 
Name Accession Description Interval E-value
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-61 5.89e-12

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 57.55  E-value: 5.89e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVPKWLgkGGFETHTLR---DELVARLRLVQTMNMQEGE 61
Cdd:COG4970    5 RRRQRGFTLIELLVVLAILAILAAIAVPSFS--SLIARQRLRaaaNELAAALRLARSEAIRRGQ 66
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-27 1.36e-06

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 42.74  E-value: 1.36e-06
                          10        20
                  ....*....|....*....|....*..
gi 757642171    1 MPRNKGFTLIELVIVILLLGILAAFAV 27
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 2-104 1.77e-06

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 44.86  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757642171    2 PRNKGFTLIELVIVILLLGILAAFAVPkWLGkGGFETHTLRD---ELVARLRLVQTMNMQEGEARCTQLVLEPSRFGhlt 78
Cdd:TIGR01708   1 HRQSGFTLIELLVVLAIMGLVAAAAAL-SLV-SHYGTKSLDQvagRLAARLRLAQTSARATGRPVLLRLGSRGIRFG--- 75

                          90       100
                  ....*....|....*....|....*.
gi 757642171   79 llgsctPKPISGWSADEqSRGRVITA 104
Cdd:TIGR01708  76 ------ERASLALPVDE-VKMTDWTG 94
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-28 3.71e-05

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 41.17  E-value: 3.71e-05
                         10        20
                 ....*....|....*....|....*...
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVP 28
Cdd:PRK10574   1 MDKQRGFTLIELMVVIAIIAILSAIGIP 28
T4P_ComGE NF041013
competence type IV pilus minor pilin ComGE;
3-58 3.14e-04

competence type IV pilus minor pilin ComGE;


Pssm-ID: 468942 [Multi-domain]  Cd Length: 83  Bit Score: 37.56  E-value: 3.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 757642171   3 RNKGFTLIELVIVILLLGILAAFAVPKWlgkggFETHTLRDELVARLRLVQTMNMQ 58
Cdd:NF041013   2 KNKGFILLESLVALALLALIVSLLLPSL-----TQIQKEREEIKQKEEALQVLYEA 52
pilin_ComGC NF040999
competence type IV pilus major pilin ComGC; ComGC, encoded in the comG operon, is the major ...
 5-28 8.81e-03

competence type IV pilus major pilin ComGC; ComGC, encoded in the comG operon, is the major pilin of a type IV pilus involved in natural transformation of monoderm bacteria (those lacking an outer membrane) such as Bacillus subtilis and Streptococcus pneumoniae. In the seed alignment, Bacillus proteins have a pair of Cys residues likely to form a disulfide bond while Streptococcus proteins lack Cys residues.


Pssm-ID: 468929  Cd Length: 84  Bit Score: 33.64  E-value: 8.81e-03
                         10        20
                 ....*....|....*....|....
gi 757642171   5 KGFTLIELVIVILLLGILAAFAVP 28
Cdd:NF040999   2 KGFTLIEMLIVLLIISVLLLLFVP 25
 
Name Accession Description Interval E-value
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-61 5.89e-12

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 57.55  E-value: 5.89e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVPKWLgkGGFETHTLR---DELVARLRLVQTMNMQEGE 61
Cdd:COG4970    5 RRRQRGFTLIELLVVLAILAILAAIAVPSFS--SLIARQRLRaaaNELAAALRLARSEAIRRGQ 66
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-32 8.16e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 55.69  E-value: 8.16e-11
                         10        20        30
                 ....*....|....*....|....*....|..
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVPKWLG 32
Cdd:COG2165    7 RRRQRGFTLIELLVVIAIIGILAALALPALQG 38
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-28 2.70e-10

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 54.70  E-value: 2.70e-10
                         10        20
                 ....*....|....*....|....*...
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVP 28
Cdd:COG4968    6 RRRQRGFTLIELMIVVAIIGILAAIAIP 33
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
3-28 2.68e-09

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 52.40  E-value: 2.68e-09
                         10        20
                 ....*....|....*....|....*.
gi 757642171   3 RNKGFTLIELVIVILLLGILAAFAVP 28
Cdd:COG4969    4 KQKGFTLIELMIVVAIIGILAAIAIP 29
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
1-30 1.15e-07

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 47.23  E-value: 1.15e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVPKW 30
Cdd:COG4537    8 LKKEKGFTLIEMLIVLLIISILLLIAVPNL 37
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-27 1.36e-06

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 42.74  E-value: 1.36e-06
                          10        20
                  ....*....|....*....|....*..
gi 757642171    1 MPRNKGFTLIELVIVILLLGILAAFAV 27
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 2-104 1.77e-06

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 44.86  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757642171    2 PRNKGFTLIELVIVILLLGILAAFAVPkWLGkGGFETHTLRD---ELVARLRLVQTMNMQEGEARCTQLVLEPSRFGhlt 78
Cdd:TIGR01708   1 HRQSGFTLIELLVVLAIMGLVAAAAAL-SLV-SHYGTKSLDQvagRLAARLRLAQTSARATGRPVLLRLGSRGIRFG--- 75

                          90       100
                  ....*....|....*....|....*.
gi 757642171   79 llgsctPKPISGWSADEqSRGRVITA 104
Cdd:TIGR01708  76 ------ERASLALPVDE-VKMTDWTG 94
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 5-33 7.30e-06

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 43.18  E-value: 7.30e-06
                          10        20
                  ....*....|....*....|....*....
gi 757642171    5 KGFTLIELVIVILLLGILAAFAVPKWLGK 33
Cdd:TIGR01710   1 RGFTLLEIMVVLVILGLLAALVAPKLFSQ 29
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 4-27 1.91e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 39.60  E-value: 1.91e-05
                          10        20
                  ....*....|....*....|....
gi 757642171    4 NKGFTLIELVIVILLLGILAAFAV 27
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-28 3.71e-05

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 41.17  E-value: 3.71e-05
                         10        20
                 ....*....|....*....|....*...
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVP 28
Cdd:PRK10574   1 MDKQRGFTLIELMVVIAIIAILSAIGIP 28
T4P_ComGE NF041013
competence type IV pilus minor pilin ComGE;
3-58 3.14e-04

competence type IV pilus minor pilin ComGE;


Pssm-ID: 468942 [Multi-domain]  Cd Length: 83  Bit Score: 37.56  E-value: 3.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 757642171   3 RNKGFTLIELVIVILLLGILAAFAVPKWlgkggFETHTLRDELVARLRLVQTMNMQ 58
Cdd:NF041013   2 KNKGFILLESLVALALLALIVSLLLPSL-----TQIQKEREEIKQKEEALQVLYEA 52
PRK10506 PRK10506
prepilin peptidase-dependent protein;
1-31 1.22e-03

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 37.28  E-value: 1.22e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFAVPKWL 31
Cdd:PRK10506   5 MKKQRGYTLIELLVVMTIVSILSAWGLYGWQ 35
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
1-27 2.72e-03

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 36.31  E-value: 2.72e-03
                         10        20
                 ....*....|....*....|....*....
gi 757642171   1 MPRNKGFTLIELVI--VILLLGILAAFAV 27
Cdd:COG4966    1 RRRQRGFTLVELMValAIGLIVLAAVLQL 29
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 1-26 4.32e-03

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 35.38  E-value: 4.32e-03
                         10        20
                 ....*....|....*....|....*.
gi 757642171   1 MPRNKGFTLIELVIVILLLGILAAFA 26
Cdd:COG4795    5 RRRQRGFTLLELLVALAIFALLLLAA 30
pilin_ComGC NF040999
competence type IV pilus major pilin ComGC; ComGC, encoded in the comG operon, is the major ...
 5-28 8.81e-03

competence type IV pilus major pilin ComGC; ComGC, encoded in the comG operon, is the major pilin of a type IV pilus involved in natural transformation of monoderm bacteria (those lacking an outer membrane) such as Bacillus subtilis and Streptococcus pneumoniae. In the seed alignment, Bacillus proteins have a pair of Cys residues likely to form a disulfide bond while Streptococcus proteins lack Cys residues.


Pssm-ID: 468929  Cd Length: 84  Bit Score: 33.64  E-value: 8.81e-03
                         10        20
                 ....*....|....*....|....
gi 757642171   5 KGFTLIELVIVILLLGILAAFAVP 28
Cdd:NF040999   2 KGFTLIEMLIVLLIISVLLLLFVP 25
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
1-27 9.88e-03

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 33.42  E-value: 9.88e-03
                         10        20
                 ....*....|....*....|....*....
gi 757642171   1 MPRNKGFTLIELVI--VILLLGILAAFAV 27
Cdd:COG4967    7 RRRQRGFTLIEVLValVILSIGLLGLAGL 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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