|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-377 |
1.60e-80 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 251.32 E-value: 1.60e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 12 LVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPL 91
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 92 WKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQALPFMISSALCLL 171
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 172 TWVFLFLIKNEFPLQEvevnslKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRIGLQVEFISLLLTSFAV 251
Cdd:cd17477 161 ALVPLLLTRRAAPEIE------EAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 252 GAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTG 331
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 757772931 332 NLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVL 377
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-381 |
1.13e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 118.06 E-value: 1.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 12 LVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPL 91
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 92 WKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSALC 169
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLadALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 170 LLTWVFLFLIKNEFPLQ---EVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGL-RIGLQVEFISLL 245
Cdd:cd17325 161 LLALVLALLLLPEPRPPpnkRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAeLGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 246 LTSFAVGAIVFQLPLGILSDKLGRK--LVLGWILSIGAMTFFTASlleDTSIPLVACLFIAGMVVGSTFSLGISYMTDLI 323
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKplILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 757772931 324 PTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFnIISGMLCCIFIVLFVFG 381
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-343 |
1.25e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 117.38 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 1 MSATHQQR---FWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAA 77
Cdd:COG2814 1 MPATPRRRwlaLLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 78 GGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIE-- 155
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 156 INQALPFMISSALCLLTWVFLFLIkneFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRI 235
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL---LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 236 -GLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLeDTSIPLVACLFIAGMVVGSTFSL 314
Cdd:COG2814 238 lGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-GSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*....
gi 757772931 315 GISYMTDLIPTRLLPTGNLLCGIAFSIGS 343
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-379 |
5.99e-27 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 110.71 E-value: 5.99e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 2 SATHQQRFWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLL 81
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 82 VIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPaDKRGRNISLYGLFFGIGFAVGPLMTPL-----IEI 156
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLlillgLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 157 NQALPFMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRI- 235
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVl 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 236 GLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGwILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLG 315
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR-LSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757772931 316 ISYMTDLIPTRLLPTGNLLcGIAFSIGSLAGPYIGGTFIqffHHISFFNIISGMLCCIFIVLFV 379
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAV-LIMGIVGGAIGPPLIGFLA---DAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-380 |
1.06e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 95.35 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 11 ILVSLVAISGFsqGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFP 90
Cdd:cd17489 2 LLANFFFFLSF--YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 91 LWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQALP--FMISSAL 168
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAvlFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 169 CLLTWVFLFLIKNEFPLQEVEVNSLKETAKRF--SKAAKYAWIAFLPPFGYGFLESSLngsfPVYGLRIGLQVefISLLL 246
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLveKKVLPPALILFLASIAYGAISTFL----PLYAAERGISN--AGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 247 TSFAVGAIVFQLPLGILSDKLGRKLVLgwilsIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGI----SYMTDL 322
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVI-----IPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFpalqALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 757772931 323 IPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFnIISGMLCCIFIVLFVF 380
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF-LLAAVVVLLALVLYIF 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-347 |
2.24e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 88.24 E-value: 2.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 12 LVSLVAISGFSQGMLLPLIAIIFEKD-GLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFP 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 91 LWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSAL 168
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLasLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 169 CLLTWVFLFLI----KNEFPLQEVEVNSLKETAKRFSKAAKYAWIaFLPPFGYGFLESSLNGSFPVYGLRIGLQVEFISL 244
Cdd:pfam07690 161 SLLAAVLLLLPrpppESKRPKPAEEARLSLIVAWKALLRDPVLWL-LLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 245 LLTSFAVGAIVFQLPLGILSDKLGRK--LVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDL 322
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRrrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 757772931 323 IPTRLLPTGNLLCGIAFSIGSLAGP 347
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-378 |
2.63e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 88.38 E-value: 2.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 23 QGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLR 102
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 103 LFIGIGDHALH-FGTQtwITSSSPADKRGRNISLYGLFFGIGFAVGPL-MTPLIEINQALPFMISSALCLLTWVFLFLIK 180
Cdd:cd17478 92 ALAGIGSAAFHpEGAR--LASQAAGGRRGLAMSIFSVGGNLGFALGPLiAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 181 NEFPLQEVEVNSLKETAKRFSKAAkyaWIAFLPPFGYGFLES----SLNGSFPVYGLRIGLQVEFISLLLTSFAVGAIVF 256
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGV---WRALLLLLIIVFLRSwvlsSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 257 QLPLGILSDKLGRKLVLgwILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCG 336
Cdd:cd17478 247 TLIGGPLSDRFGRRRVI--IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 757772931 337 IAFSIGSLAGPYIGGTfiqffhhISFFNIISGMLCCIFIVLF 378
Cdd:cd17478 325 LSFGLGGIGAPVLGAL-------ADAFGLESVLLILALLPLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-383 |
1.68e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.47 E-value: 1.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 8 RFWILVSLVAISGFSQGMLLPLIAIIFEKD-GLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSL 86
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 87 ALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQAL--PFMI 164
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWrnAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 165 SSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYG-LRIGLQVEFIS 243
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 244 LLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLI 323
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757772931 324 PTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFH--HISFFNIISGMLCCIFIVLFVFGQK 383
Cdd:COG2223 325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsyTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-379 |
8.67e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.02 E-value: 8.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 12 LVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPL 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 92 WKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI----EINQALPFMISSA 167
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 168 LCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAA-----KYAWIAFLPPFGYGFLESSLNGSFPVYGLRIGLQ-VEF 241
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKrvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 242 ISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTD 321
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 757772931 322 LIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFV 379
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-385 |
3.56e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 3.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 9 FWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLAL 88
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 89 FPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQA--LPFMISS 166
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwrAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 167 ALCLLTWVFLFliknefplqevevnslketakrfskaakyaWIAFLPPFGYGFLESSLNGSFPVY-GLRIGLQVEFISLL 245
Cdd:COG2271 172 LPGLLLALLRF------------------------------WLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 246 LTSFAVGAIVFQLPLGILSDKLGR--KLVLGWILSIGAMTFFTASLLEDTSIpLVACLFIAGMVVGSTFSLGISYMTDLI 323
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPAL-AIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757772931 324 PTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVFGQKMP 385
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-380 |
6.25e-17 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 81.50 E-value: 6.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAIIFEKD-GLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLAL 88
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 89 FPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLM-TPLIEINQALPFMISSA 167
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLYSFRLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 168 LCLL-TWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRI-GLQVEFISLL 245
Cdd:cd17329 162 LFLLaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 246 LTSFAVGAIVFQLPLGILSDKLGRKLVLgwilsIGAMTFFTASLLEDTSIPLVACLFIAGMV--VGSTFSLGIS--YMTD 321
Cdd:cd17329 242 LALNALLIVLLQFPVARLVERFRLRKIL-----MIGILLFAIGFAVLAFANTLAVLILAMIVltLGEMLVFPAVqtLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 757772931 322 LIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVF 380
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-381 |
8.49e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 81.46 E-value: 8.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 2 SATHQQRFWILVSLVAIS---GFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAG 78
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVAlnlRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 79 GLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPaDKRGRNISLYGLFFGIGFAVGPLMTPLIEINQ 158
Cdd:COG2807 90 LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 159 --ALPFMISSALCLLTWVFLFLIKNEFPLQEVEVNSlKETAKRFSKAAKyAWIAFLPPFGYGFLESSLNGSFPVYGLRIG 236
Cdd:COG2807 169 gwRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA-AASLRSLWRSPL-AWLLTLFFGLQSLLYYAVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 237 LQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIaGMVVGSTFSLGI 316
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL-GLGQGGLFPLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757772931 317 SYMTDLIPTRlLPTGNLLcGIAFSIGSL---AGPYIGGTFIQFFHHisfFNIISGMLCCIFIVLFVFG 381
Cdd:COG2807 326 TLIGLRARTP-AEAAALS-GMAQSVGYLlaaLGPLLVGALHDATGS---WTAALLLLAALAVLMLVAG 388
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-180 |
2.07e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 5 HQQRFWILVSLVAISGFSQGMLLPLIAI-IFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVI 83
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 84 VSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALP 161
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLydAFGFATP 356
|
170
....*....|....*....
gi 757772931 162 FMISSALCLLTWVFLFLIK 180
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-378 |
8.75e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.05 E-value: 8.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 9 FWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLAL 88
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 89 FPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI-EINQALPFMISSA 167
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLaAISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 168 LCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVY-GLRIGLQVEFISLLL 246
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLlELLYGISPIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 247 TSFAVGAIVFQLPLG-ILSDKLGRKLVLgwILSIGAMTFFTASLLEDTSIP-LVACLFIAGMVVGSTFSLGISYMTDLIP 324
Cdd:cd17474 241 AGWSVLLALGSLFVGrLLKKRFGARRIL--VIGLLLYALSLLLLGFVPSLAlLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 757772931 325 TRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLF 378
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
68-345 |
2.27e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.92 E-value: 2.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 68 RYG-YKPIIAAGGLLVIVSLALFP----------LWKSVVFWFVLRLFIGIGDHALhfgtQTWITSSSP-ADKRGRNISL 135
Cdd:COG2211 76 RWGrRRPWILIGAIPLALSFVLLFtapdlsptgkLIYALVTYLLLGLAYTLVNIPY----SALGAELTPdYEERTRLSSW 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 136 YGLFFGIGFAVGPLMTPLI--------EINQALPFMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAaKYA 207
Cdd:COG2211 152 RFAFAGLGGLLASVLPPPLvaafggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKN-RPF 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 208 WIAFLPPFGYGFLESSLNGSFPVYGL-RIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFT 286
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 287 ASLLEDTSIPLV-ACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLA 345
Cdd:COG2211 311 LFFLGPGNLWLLlVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFA 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-379 |
1.66e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.91 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 208 WIAFLPPFGYGFLESSLNGSFPVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTA 287
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 288 SLLeDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFF--HHISFFNI 365
Cdd:COG2814 93 ALA-PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgwRWVFLVNA 171
|
170
....*....|....
gi 757772931 366 ISGMLCCIFIVLFV 379
Cdd:COG2814 172 VLALLALLLLLRLL 185
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-374 |
3.03e-10 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 61.06 E-value: 3.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 52 YLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGR 131
Cdd:cd17317 35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 132 NISLYGLFFGIGFAVGPLMTPLIEINQALPFMISSALCLLTWVFLFLIKNEFplqevevnslketakrfskAAKYAWIAF 211
Cdd:cd17317 115 VGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLPRRTI-------------------IVGLIWFVT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 212 -LPPFGYGFLESSLNGSFPVYGLRIGLqVEFISLLLtsfavgaivfqlpLGILSDKLGRKLVLGWILSIGAMTFFTASLL 290
Cdd:cd17317 176 sLVYYGLSLNSSNLGGNLYLNFFLSGL-VEIPAYFL-------------ALLLLDRLGRRWTLSGSLLLAGLACLVTALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 291 EDTSIPLVACLFIAG-MVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIG--GTFIQFFHHISF--FNI 365
Cdd:cd17317 242 PDDENTLALTLALVGkFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVllGKIGPLLPLIIFgvLAL 321
|
....*....
gi 757772931 366 ISGMLCCIF 374
Cdd:cd17317 322 LGGLLTLLL 330
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-379 |
3.47e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 3.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALF 89
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 90 PLWKSVVFWFVLRLFIGIGDHALHFgTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSA 167
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLstPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 168 LCLLTWVFLFLIknefplqevevnslketakrfskaAKYAWIAFLPPFGYGFLESSLNGSFPVYGL-RIGLQVEFISLLL 246
Cdd:cd17330 161 LALLNLVLVLFF------------------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKdRFGFSPSQIGLLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 247 TSFAVGAIVFQLPL-GILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIpLVACLFIAGMVVGSTFSLGISYMTDLIPT 325
Cdd:cd17330 217 ALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPL-LVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 757772931 326 RLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFV 379
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
10-379 |
8.38e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.03 E-value: 8.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAIIFekdGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALF 89
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAF---NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 90 PLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGlFFGIGFAVGPLMTPLI---EINQALPFMISS 166
Cdd:cd17333 79 FATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHG-FFGLGALIGPLIATSLltsELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 167 ALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAK---YAWIAFLPPFGYGFLESSLNGSFPVYGLR-IGLQVEFI 242
Cdd:cd17333 158 LIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLrnpSIILGALALFLYVGAETAFSSWVPSYLVEkKHVSDGLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 243 SLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSiGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDL 322
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGS-GALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISN 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 757772931 323 IPTRLLPTGNLLCgIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFV 379
Cdd:cd17333 317 LPYAKGKGTSVLL-AAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
67-379 |
1.13e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 67 RRYGYKPIIAAGGLLVIVS---LALFPLWKSVVFWFVL-RLFIGIGDHAlhfgTQTWITSSSPADKRGRNISLYGLFFGI 142
Cdd:cd17370 60 RTGKRKPLVILGYGLSALAkplLALAGSWQLVLLLRILeRLGKGIRTPP----RDALLADATPPSGRGKAFGLHRALDTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 143 GFAVGPLMT----PLIEINQALPFMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYG 218
Cdd:cd17370 136 GAVLGPLLAalllYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALG 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 219 FLesslngSFPVYGLRI---GLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSI 295
Cdd:cd17370 216 NF------SFAFLILRAqelGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 296 PLVAClFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFnIISGMLCCIFI 375
Cdd:cd17370 290 LLLGF-ILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF-LFSAVLALIAL 367
|
....
gi 757772931 376 VLFV 379
Cdd:cd17370 368 LLLL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-380 |
1.30e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.13 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 13 VSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFiSPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLW 92
Cdd:cd17355 10 LILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLA-QPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 93 KSV-VFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIG-FAVGPLMTPLIE-INQALPFMISSALC 169
Cdd:cd17355 89 TSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALIEaFGWRTALLVLALLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 170 LLT----WVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYA--WIAFLPPFGYGFLESSLNGSFPVYGLRIGLQVEFIS 243
Cdd:cd17355 169 LLVlvpvLLLLRRRPADLALRAYDDASPASPGSTLKEALRSAsfWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 244 LLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLI 323
Cdd:cd17355 249 VALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYF 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 757772931 324 PTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVF 380
Cdd:cd17355 329 GARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-380 |
1.86e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.50 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 215 FGYGFLESSLNGSFPVY-GLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTAsLLEDT 293
Cdd:pfam07690 6 FLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL-LFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 294 SIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCI 373
Cdd:pfam07690 85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLA 164
|
....*..
gi 757772931 374 FIVLFVF 380
Cdd:pfam07690 165 AVLLLLP 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-146 |
5.31e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 5.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 8 RFWILVSLVAISGFSQGMLLPLIAIIF-EKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSL 86
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 87 ALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAV 146
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-286 |
9.48e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.28 E-value: 9.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 9 FWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLAL 88
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 89 FPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQA--LPFMISS 166
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGwrWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 167 ALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRIGLQVEFISLLL 246
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 757772931 247 TSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFT 286
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
45-182 |
1.47e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 50.34 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 45 GLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSS 124
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 125 PADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSALCLLTWVFLFLIKNE 182
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLaqFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
68-378 |
2.00e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.22 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 68 RYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGF--- 144
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGAlla 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 145 -AVGPLMTPLIEINQA--LPFMISSALCLLTWVFLfliknefplqevevnslketakrfskaaKYAWIAFLPPFGYGFLE 221
Cdd:cd17316 142 aLVASLLIPLLSGDWGwrILFLIGALPALLALLLR----------------------------RRTLLLILLWFFISFGY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 222 SSLNGSFPVYGLRI-GLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGW-ILSIGAMTFFTASLLEDTSIPLVA 299
Cdd:cd17316 194 YGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIgLILSGILALPLFYLLSGSPTLLLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 300 CLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLC-GIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLF 378
Cdd:cd17316 274 LLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSyNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-382 |
6.60e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 6.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 53 LGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALfPLWKSVVFW-FVLRLFIGIGDHALHFGTQTWITSSSPADKRGR 131
Cdd:cd17473 46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA-GLFLDSLYAlLASRALLGIGVAGIMTLATALIGDYFEGEERAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 132 NISLYGLFFGIGFAVGPLMT-PLIEINQALPFMI-SSALCLLTWVFLFLiknefplQEVEVNSLKETAKRFSKAAKYAWI 209
Cdd:cd17473 125 MLGLQSAAMSLGGVVFLLLGgALAEIGWRAPFLVyLLALPVLILVLLFL-------PEPARKSKSAASPGAATAAALPWK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 210 AFLPPFGYGFLESSLNGSFPVY-----GLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTF 284
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPIQlpfllQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 285 FTASLLEDTSIpLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFN 364
Cdd:cd17473 278 LLLALASGLWV-VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF 356
|
330
....*....|....*...
gi 757772931 365 IISGMLCCIFIVLFVFGQ 382
Cdd:cd17473 357 LILGVLALVLAIVLLLLR 374
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
53-381 |
9.46e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 50.49 E-value: 9.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 53 LGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVF-WFVLRLFIGIGDHALHFGTQTWITSSSPaDKRGR 131
Cdd:cd17314 49 LGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPlSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 132 NISLYGLFFGIGfavgplMTPLIEINQALPFMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAW--- 208
Cdd:cd17314 128 ALGLPTTGYSLG------LVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTmge 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 209 -----------IAFLPPFGYGFLESSLNGSFPVYGLriGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWIL 277
Cdd:cd17314 202 ifrdkvfwilfIAIFLVLIGGFLFIANMASLVRSLQ--LDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSIL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 278 SIGAMTFFTASLLEDTSIP--LVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQ 355
Cdd:cd17314 280 LTILGLGLCAFLFLLKMTPvgLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYD 359
|
330 340
....*....|....*....|....*.
gi 757772931 356 FFHhisffNIISGMLCCIFIVLFVFG 381
Cdd:cd17314 360 RTP-----SYISAVYIYAVIVFLASA 380
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
242-375 |
1.48e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.48 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 242 ISLLLTSFAVGAIVFQLPLGILSDKLGRKlvlgWILSIGAMTFFTASLLEDTSIP---LVACLFIAGMVVGSTFSLGISY 318
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRK----WVLLIAIVIFELGSLLCGLAPNmtmLIVGRAIQGIGGGGLMSLAFII 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 757772931 319 MTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFF--HHISFFNIISGMLCCIFI 375
Cdd:cd17502 108 IADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLswRWCFYINLPIGGLALALL 166
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-380 |
2.83e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.77 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 9 FWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLAL 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 89 FPLW-----KSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALP 161
Cdd:cd06173 81 LALLallgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvaLLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 162 FMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAK----RFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRI-G 236
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLreglRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 237 LQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTsIPLVACLFIAGMVVGSTFSLGI 316
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL-WLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757772931 317 SYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVF 380
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
50-354 |
3.55e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.51 E-value: 3.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 50 GLYLGILFISPFMEaplrRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKR 129
Cdd:TIGR00895 64 GMAFGALFFGPLAD----RIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 130 GRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSA----LCLLTWVFL-----FLIK-----------------N 181
Cdd:TIGR00895 140 GTAVGLMFCGYPIGAAVGGFLAGWLipVFGWRSLFYVGGIapllLLLLLMRFLpesidFLVSkrpetvrrivnaiapqmQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 182 EFPLQEVEVNSLKETAKRFSKAA----KYAWIAFLPPFGYGFLESS---LNGSFPVYGLRIGLQVEFISLLLTSFAVGAI 254
Cdd:TIGR00895 220 AEAQSALPEQKSTQGTKRSVFKAlfqgKTARITVLLWLLYFMLLVGvyfLTNWLPKLMVELGFSLSLAATGGALFNFGGV 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 255 VFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVAcLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGnll 334
Cdd:TIGR00895 300 IGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLL-GAIAGFFVNGGQSGLYALMALFYPTAIRATG--- 375
|
330 340
....*....|....*....|...
gi 757772931 335 CGIAFSIG---SLAGPYIGGTFI 354
Cdd:TIGR00895 376 VGWAIGIGrlgAIIGPILAGYLL 398
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
215-385 |
4.84e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.19 E-value: 4.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 215 FGYGFLESSLNGSFPVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTS 294
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 295 IpLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFhHISFFNIISGMLCCIF 374
Cdd:cd06174 86 L-LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-GFGWRAVFLIAAALAL 163
|
170
....*....|.
gi 757772931 375 IVLFVFGQKMP 385
Cdd:cd06174 164 LAAILLLLVVP 174
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
12-379 |
5.10e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.93 E-value: 5.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 12 LVSLVAISGFSQGMLLPLIAIIFekdglsstINGLNATGLYLGILFISPFMEAPL----------RRYGYKPIIAAGGLL 81
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFL--------TEELGASPLQIGIFMTLSALSGIVvsqwlgrlsdRGGDRKPLILLALLA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 82 VIVSLALFPLWKSvvFWFVL---RLFIGIGDHALhfgTQTWITSSSPADKRGRN-----ISLYGLFFGIGFAVGPLMTPL 153
Cdd:cd17471 73 GALGYLLFAFLRN--YWVLLlvgVVLLSLGAAAF---PQLFALAREYADRSSGRdatlfNSVLRAAFSLAWVIGPPLAFL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 154 I--EINQALPFMISSALCLLTWVF-LFLIKNEfplQEVEVNSLKETAKRFSKAAKYAWIAFLPpFGYGFLESSLNG-SFP 229
Cdd:cd17471 148 LldVLGFTGLFLLAALLYLVVALLvLFLLPSV---KPPAQKATPASSLVKAPVNRRLLLLFAA-FTLLFAANSMYIiAMP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 230 VYGLR-IGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLG-RKLVLGWILSigAMTFFTASLLEDTSIPLVACLFIAGMV 307
Cdd:cd17471 224 LYVTNeLGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGkRRLLLAGFLA--GVLFYLGLALATSLWQLIALQLLNAIF 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757772931 308 VGSTFSLGISYMTDLIPTRlLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFnIISGMLCCIFIVLFV 379
Cdd:cd17471 302 IGITAGLGISYFQDLMPGQ-PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVF-LVCAVLALLALVLLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
14-359 |
7.19e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 7.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 14 SLVAISGFSQGmLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWK 93
Cdd:cd17475 4 AQAAASLVAQG-IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 94 SVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQALP--FMISSALCLL 171
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRaaFVVAGLVSIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 172 TWVFLFLIKNEFPLQEVEvnSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGL-----RIGLQVEFISLLL 246
Cdd:cd17475 163 AAVLFWLFYREPPAASAA--TESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLlflhdHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 247 TSFAVGAIVFQLPLGILSDKLG---RKLVLGWILSIGAMTFFTASLLED--TSIPLVACLFIAGMVVGSTFSLGISYMTD 321
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPgtPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 757772931 322 LIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHH 359
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHS 358
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
260-380 |
1.07e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.22 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 260 LGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAF 339
Cdd:cd17353 269 WGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAK 348
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 757772931 340 SIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVF 380
Cdd:cd17353 349 GVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
68-383 |
1.63e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 46.44 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 68 RYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGdhALHFGTQTWITSSSPADKRGRNISLYGLFFGI----G 143
Cdd:cd17472 58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADLTREENRTKAMALIGASIGIafaiS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 144 FAVGPLMTPLIEINQAlpFMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAflppFGYGFLESS 223
Cdd:cd17472 136 MVLGPLLAAHLGVSGL--FLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLD----FSIFILHFV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 224 LNGSF---PVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRK---LVLGWIL-SIGAMTFFTASLLEDTSIP 296
Cdd:cd17472 210 LMAFFyilPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMkqvFVSSILLiAVGFLLLLFAATSLWLLII 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 297 LVACLFIAGMVVGSTFslgISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQffHHISFFNIISGMLCCIFIV 376
Cdd:cd17472 290 GLIIFFIGFNLLEALL---PSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWG--LLGYSSVFLTILILALLWL 364
|
....*..
gi 757772931 377 LFVFGQK 383
Cdd:cd17472 365 LVSFLLP 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-179 |
2.44e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 5 HQQRFWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIV 84
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 85 SLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPF 162
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLadALGLSAVF 366
|
170
....*....|....*..
gi 757772931 163 MISSALCLLTWVFLFLI 179
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
242-391 |
2.94e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.62 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 242 ISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIpLVACLFIAGMVVGSTFSLGISYMTD 321
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL-LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 322 LIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVFGQKMPMQQKTS 391
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS 184
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
236-355 |
4.02e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.27 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 236 GLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLG 315
Cdd:cd17365 202 GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGL 281
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 757772931 316 ISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQ 355
Cdd:cd17365 282 YALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLA 321
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
222-357 |
4.17e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.80 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 222 SSLNGSFPVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLgwILSIGAMTFFT-ASLLEDTSIPLVAC 300
Cdd:COG0477 31 TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL--LIGLLLFGLASlLCGLAPSPELLIAA 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 757772931 301 LFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFF 357
Cdd:COG0477 109 RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
11-358 |
9.06e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.22 E-value: 9.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 11 ILVSLVAISGFSQGMLLPLIaiiFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFP 90
Cdd:cd06180 6 ALAVAMGIGRFAYTPLLPLM---LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 91 LWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEI---NQALPFMISSA 167
Cdd:cd06180 83 LTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGgglSWRAGWLALAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 168 LCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLngsfPVYGLRIGLQVEFISLLLT 247
Cdd:cd06180 163 LSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFL----PLIARETGAGSLLAGLLWS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 248 SFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTfFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRl 327
Cdd:cd06180 239 LFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVG-VLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPA- 316
|
330 340 350
....*....|....*....|....*....|..
gi 757772931 328 lPTGNL-LCGIAFSIGSLAGPYIGGTFIQFFH 358
Cdd:cd06180 317 -APRALaLMTASFGVGQILGPLLAGWLADATG 347
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
10-380 |
1.26e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.72 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNAT----GLYLGILFISPFMEaplrRYGYKPIIAAGGLLVIVS 85
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSayllGFALGQLLYGPLSD----RFGRRPVLLAGLLLFILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 86 LALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQALP---- 161
Cdd:cd17320 78 SLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRaifv 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 162 FMISSALCLLTWVFLFLikNEFPLQEVEVNSLKETAKRFSKAAK--YAWI-AFLPPFGYGFLESSLNGSFPVYGLRIGLQ 238
Cdd:cd17320 158 FLALLGLLLLLLVLLFL--PETLPEEKRKPLLSSLLRAYKRVLKnrRFLGyALALGLSFAGLFAYLAAAPFIYIEQLGLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 239 VEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSI----GAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSL 314
Cdd:cd17320 236 PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLllaaALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757772931 315 GISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGgtfiqFFHHISFFNIISGMLCCIFIVLFVF 380
Cdd:cd17320 316 ATSLALEPFPHVAGTASALLGFLQFLIGALAGALVG-----LLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
100-346 |
1.43e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.67 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 100 VLRLFIGIGDHALHFGTQTWITSSSPADKRGrnisLYGLFFGIGFAVGPLM-TPLIEINQAL-------------PFMIS 165
Cdd:cd17369 110 LLRLLQGLALGGEWGGAVLMAVEHAPPKRRG----FYGSFPQLGAPVGLLLaTGVFLLLSALlsdeaflswgwriPFLLS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 166 SALCLL-TWVFLFLikNEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGL-----RIGLQV 239
Cdd:cd17369 186 AVLVAVgLYIRLRL--EETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALsyatqTLGVDR 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 240 EFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGW-ILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGI-- 316
Cdd:cd17369 264 STVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAgALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPqa 343
|
250 260 270
....*....|....*....|....*....|
gi 757772931 317 SYMTDLIPTRLLPTGnllCGIAFSIGSLAG 346
Cdd:cd17369 344 AFLAELFPTRVRYTG---ASLGYQLGAILG 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-380 |
1.66e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 38 GLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQ 117
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 118 TWITSSSPADKRGRNISLYGLFFGIGFAVG-PLMTPLIEIN--QALPFMISSALCLLTWVFLFLIKNefplqevevnslk 194
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGpPLSGWLLLLFgwRWAFIIEGLLGLLLAVLWWFYLRQ------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 195 etakrfskaakyAWIAFLPPFGYGFLESSLNGSFPVYGLRI-GLQVEFISLLLTSFAVGAIVFQLPLGILSDKL--GRKL 271
Cdd:cd17319 181 ------------VWGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARR 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 272 VLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGG 351
Cdd:cd17319 249 LVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIG 328
|
330 340
....*....|....*....|....*....
gi 757772931 352 TFIQFFHHISFFNIISGMLCCIFIVLFVF 380
Cdd:cd17319 329 YLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-179 |
1.79e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 38 GLSSTINGLNATGLYLGILFISPFMEAPL-RRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDHALHFGT 116
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 757772931 117 QTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQAL--PFMISSALCLLTWVFLFLI 179
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLsaPFLVGAAIALAAAVLLALL 374
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
219-378 |
3.14e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 42.63 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 219 FLESSLNGSFPvYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRK--LVLGWILSIGAMTFFTASLLEDTSIP 296
Cdd:cd17357 29 FINDTLVDRYG-LNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKngLLISNALLVVSSLLMFLSKSAKSPEL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 297 LVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFI----QFFHHISFFNIISGMLCC 372
Cdd:cd17357 108 LIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVlgteTLWPYLLFFPGIPALLQL 187
|
....*.
gi 757772931 373 IFIVLF 378
Cdd:cd17357 188 AALPFF 193
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
10-149 |
3.14e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.54 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAIIFEKD-GLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLAL 88
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757772931 89 FPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPaDKRGRNISLYGLFFGIGFAVGPL 149
Cdd:cd17324 281 TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAA 340
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
68-182 |
3.15e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 68 RYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFIGIGDhALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVG 147
Cdd:cd17388 64 RFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG-ATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAG 142
|
90 100 110
....*....|....*....|....*....|....*.
gi 757772931 148 PLMTPLI-EINQALPFMISSALCLLTWVFLFLIKNE 182
Cdd:cd17388 143 PALGGLLgEISPRAPFLVAAGLNGLNFLLGLFVLPE 178
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
243-312 |
5.20e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.84 E-value: 5.20e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757772931 243 SLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGA-MTFFTASLLEDTSIPLVACLFIAGMVVGSTF 312
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITAlLTLLTPLAARGGYGALIVLRILQGLAQGVTF 129
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-378 |
5.29e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 5.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 26 LLPLIAIIFekdGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVLRLFI 105
Cdd:cd17324 21 LLPDIARDF---GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 106 GIGdHALHFG-TQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSALCLLTWVFLFLIKNE 182
Cdd:cd17324 98 GLA-HGGFWAiAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgqLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 183 FPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGflesSLNGSFPVYGLRI----GLQVEFISLLLTSFAVGAIVFQL 258
Cdd:cd17324 177 LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFG----GFFALYTYLAPFLtdvpGFSSSAIIGLLLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 259 PLGILSDKLGRKLVLGWILSIGAMTFFTAsLLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPtRLLPTGNLLCGIA 338
Cdd:cd17324 253 LAGRLADRGGRRALLIALLLLAAALLLLT-LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 757772931 339 FSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLF 378
Cdd:cd17324 331 YNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
7-180 |
7.13e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 7.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 7 QRFWILVSLVA-ISGFSQGMLLPLIAIIFEKD-----GLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGL 80
Cdd:cd17504 176 RRNVLLANITAlLAGFGMFMVFQLLPQLLQLPtptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 81 LVIVSLALFPLWKSVVFW-FVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEINQA 159
Cdd:cd17504 256 ISAVGLLLLALLHSSLWAlVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYT 335
|
170 180 190
....*....|....*....|....*....|....*.
gi 757772931 160 LP---------------FMISSALCLLTWVFLFLIK 180
Cdd:cd17504 336 VSitsggvptegayvlaFLIGAALALAALLLSLLIP 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-178 |
1.04e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAI-----IFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIV 84
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIqlpflLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 85 SLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLM-TPLIEINQAL--P 161
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLsgA 355
|
170
....*....|....*..
gi 757772931 162 FMISSALCLLTWVFLFL 178
Cdd:cd17473 356 FLILGVLALVLAIVLLL 372
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
21-179 |
1.10e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.67 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 21 FSQGMLLPLIAIIFEKDGLSSTINGLNATgLYLGI-LFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWF 99
Cdd:cd17390 10 FGVSMILPLLSTHIRSLGASPTVIGLIGS-VYGALqLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 100 VLRLFIGIGDHALHfGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTP-LIEIN--QALPFMISSALCLLTWVFL 176
Cdd:cd17390 89 LSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGhLAETDggFYYVALLCSAIFILNAGLV 167
|
...
gi 757772931 177 FLI 179
Cdd:cd17390 168 WFL 170
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
243-379 |
1.21e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 40.66 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 243 SLLLTSFAVGA-----IVFQLPLGILSDKLGRKLvlgwILSIGAMTFFTASLL--EDTSIP-LVACLFIAGMvvGSTFSL 314
Cdd:cd17472 30 TPTLIGLALGIygltqAIFQIPFGLLSDRIGRKP----VILFGLLLFIAGSLLaaYATSIYgLILGRALQGS--GAISSV 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757772931 315 GISYMTDLIP----TRLLPTGNLLCGIAFSIGSLAGPYIGGTFiqFFHHISFFNIISGMLCCIFIVLFV 379
Cdd:cd17472 104 VMALLADLTReenrTKAMALIGASIGIAFAISMVLGPLLAAHL--GVSGLFLITAILSLVSLLILLFFV 170
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
10-350 |
1.22e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 40.83 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 10 WILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNAT----GLYLGILFISPFMEaplrRYGYKPIIAAGGLLVIVS 85
Cdd:TIGR00710 8 LLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTlyllGFAAGQLLWGPLSD----RYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 86 LALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLIEIN---QALPF 162
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWlswHAIFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 163 MISSALCLLTWVFLFLIKNEFPLQEVEVNSLK-ETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSFPVYGLRIGLQVEF 241
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETLPYEARIQISTYfETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 242 ISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGIS---- 317
Cdd:TIGR00710 244 FGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSiama 323
|
330 340 350
....*....|....*....|....*....|...
gi 757772931 318 YMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIG 350
Cdd:TIGR00710 324 YALEDFPHVAGTASALFGTLRLVLGAIVGYLVS 356
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
227-367 |
1.65e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 40.44 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 227 SFPVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFtASLLEDTSIPLVACLFIAGM 306
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL-GLALSNNIETLLVLRFVQAF 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757772931 307 VVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIIS 367
Cdd:TIGR00710 106 GASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLS 166
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
110-380 |
1.71e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 110 HALHfGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPFMISSALCLLTW--VFLFLIKNEFPL 185
Cdd:cd17331 102 HAMQ-AAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLtkKFGEQAAALVAAVGSLLSIvlVILLIPSNTKSK 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 186 QEVEVNSLKETAKRFSKAA-------KYAWIAFLPPFGYGFLESSLNGSFPVYGL-RIGLQVEFISLLLTSFAVGAIVFQ 257
Cdd:cd17331 181 REKEAKESASPPSVFNLKEilrllrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMdFFGLTPEENGYLMSYAGVLGMVVQ 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 258 -LPLGILSDKLGRKLVLgwILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGI-SYMTDLIPTRLLPTGNLLC 335
Cdd:cd17331 261 gLLVGPLTKRFGERSLL--KLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVItSLLTKAVPPEDTGTALGLS 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 757772931 336 GIAFSIGSLAGPYIGGTFIQFFHHISFfniisGMLCCIFIVLFVF 380
Cdd:cd17331 339 HALFSLVRTVSPTIGGALLQAYGFPSF-----GLLGAAINGLLTV 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
236-385 |
2.07e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.90 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 236 GLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTsIPLVACLFIAGMVVGSTFSLG 315
Cdd:cd17329 31 GLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP-WLFAIALVLTGFGGGLFEPAS 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 316 ISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIISGMLCCIFIVLFVFGQKMP 385
Cdd:cd17329 110 EAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRP 179
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
68-380 |
2.35e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 68 RYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFVL---RLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGF 144
Cdd:pfam00083 72 RFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGI 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 145 AVGP-LMTPLIEINQALPFMISSALCLLTWVFLFLI--------------------------KNEFPLQEVEVNSLKETA 197
Cdd:pfam00083 152 LLAYiFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGllflpesprwlvekgrleearevlakLRGVPDVDRELDEIKDSL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 198 KRFSKAAKYAWIAFLPPFGY-----------GFLESSLNGSFPVYGLRIGLQVEFISLLLTSFAVGAI-VFQLPLGI-LS 264
Cdd:pfam00083 232 EAGQEAEKASWKELFSTKTRrqrlligvmlqIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVnFVFTFIAIfLV 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 265 DKLGRKLVLGWILSIGA--MTFFT--ASLLEDTSIPLVACLFIAGMVVGSTFSLGI-----SYMTDLIPTRLLPTGNllc 335
Cdd:pfam00083 312 DRFGRRPLLLLGAAGMAicFVILGivALLGVSKSDWAGIVAIVFIALFIAFFAMGWgpvpwVIVSELFPLSVRSKAM--- 388
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 757772931 336 GIAFSIGSLAGPYIGGTFIQFFHHIS---FFNIISGMLCCIFIVLFVF 380
Cdd:pfam00083 389 ALATAANWLANFLIGFLFPIITDAIGlgyTFFIFAGLLVLFIIFVFFF 436
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
72-382 |
2.49e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 72 KPIIAAGGLLVIVSLALFPLWKSVVFWF----------VLRLFIGIGDHALHFG---TQTWITSSSPADKRGRNISLYGL 138
Cdd:cd17313 69 RPFILVGAPLAALGLILIPNAADIGLALgdgprtwalvLFVLGIVLLDFAMNVCqgpVRALLPDLVPPEQRSKANGIINF 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 139 FFGIG----FAVGPLMTPLIEINQAL------PFMISSALCLLTWVFLFLIKNEFPLQEVEVNSLKETAKRFSKAAKY-- 206
Cdd:cd17313 149 MGGLGgvlgYLLGAILWDHNWFGFALggnlkvPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLkl 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 207 -----------------AWIAFLP--PFGYGFLESSLNGSFPVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKL 267
Cdd:cd17313 229 lkimprsllrlllviffWWIAFFPfeLFFTDYMGEEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKI 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 268 GRKLVlgWILSIGAMTFFTASL-LEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGnLLCGI---AFSIGS 343
Cdd:cd17313 309 GRKKV--YLIGLVLFAVGMALMaLVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQG-TDTGLlnlAISLAQ 385
|
330 340 350
....*....|....*....|....*....|....*....
gi 757772931 344 LAGPYIGGTFIQFFhhiSFFNIISGMLCCIFIVLFVFGQ 382
Cdd:cd17313 386 ILVSLLAGPIIDVK---GYGTVFPVAAVASFLSLVGALF 421
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-182 |
2.67e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 8 RFWILVSLVAISGFSQ-GMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYG--YKPIIAAGGLLVIV 84
Cdd:COG2271 181 RFWLLALAYFLVYFALyGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 85 SLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLI--EINQALPF 162
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLldATGYQAAF 340
|
170 180
....*....|....*....|
gi 757772931 163 MISSALCLLTWVFLFLIKNE 182
Cdd:COG2271 341 LLLAALALLAALLALLLLRE 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
7-148 |
3.51e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 7 QRFWILVSLVAISGFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIV-- 84
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaa 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 757772931 85 -SLALFPLWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGP 148
Cdd:pfam07690 280 lGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
244-379 |
3.54e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.14 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 244 LLLTSFAVGAIVFQLPLGILSDKLGRKlvlgWILSIGaMTFFTASLLEDTSIPLVACLFIAGMVVG----STFSLGISYM 319
Cdd:cd17328 38 LLQTVFIISYMVLSPIFGYLGDRYNRK----WILAVG-ILIWSAATLLSSFAPNFWQLLLFRALVGigeaSYSPIAPTII 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757772931 320 TDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFFNIIS---GMLCCIFIVLFV 379
Cdd:cd17328 113 ADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTgvlGVLLAILLLLFV 175
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
91-379 |
3.56e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.18 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 91 LWKSVVFWFVLRLFIGIGDHALHFGTQTWITSSSpadkRGRNISLYGLFFGIGFAVGPLMTPLIEINQA--LPFMISSAL 168
Cdd:cd17312 91 LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE----RGTVYGIWSTSHNFGGILAPILAASLASYYGwrAAFLVPGIV 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 169 CLLTWVFLFL-IKNEFPLqeVEVNSLketAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSfpvyglriglqvefiSLLLT 247
Cdd:cd17312 167 GLVVAIILFFfLRDSPPY--VWVLSL---AYAFVYIVRYACLDWGPLYLYEVKGYSLIDA---------------GWFSS 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 248 SFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGA-MTFFTASLLEDTSIPLVA--CLFIAGMVV-GSTFSLGISYMTDLI 323
Cdd:cd17312 227 LYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLlMTLSLALFWFFPHNKLLSivLLFLIGFFVgGPINLIGGAAAQDIG 306
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 757772931 324 PTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFH--HISFFNIISGMLCCIFIVLFV 379
Cdd:cd17312 307 RKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGwsTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
256-357 |
3.67e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 39.35 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 256 FQLPLGILSDKLGRKLVLGWILSIGAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGI----SYMTDLIPTRLLPTG 331
Cdd:pfam05977 61 LSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDpawqASVPELVPRRDLPAA 140
|
90 100
....*....|....*....|....*.
gi 757772931 332 NLLCGIAFSIGSLAGPYIGGTFIQFF 357
Cdd:pfam05977 141 VALNSVGYNIARSVGPALGGVLLAAF 166
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-363 |
4.04e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 4.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 29 LIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALF----PLWKSVVFWFVLRLF 104
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFgfstSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 105 IGIGDHALHFGTQTWItsssPADKRGRNISLY--GLFFGIGFAVGPLMTPLIEINQALPFMISSALCLLTWVFLFLIK-- 180
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWF----SRSERGTWVSFWncSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLlr 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 181 -----------NEFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLesslnGSFPVYGLRIG---------LQVE 240
Cdd:TIGR00881 173 dspqscglppaEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISL-----GYVFVYVVRTGildwsplylTQEK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 241 FISLLLTSFA-----VGAIVFQLPLGILSDKL--GRKLVLGWIlsigAMTFFTASLLEDTSIP------LVACLFIAGMV 307
Cdd:TIGR00881 248 GFSKEKASWAftlyeLGGLVGTLLAGWLSDKLfnGRRGPLAVF----FMALIIVSLLVYWLNPaanplmDLICLFALGFL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 757772931 308 VGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFF 363
Cdd:TIGR00881 324 VYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
242-357 |
4.91e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 4.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 242 ISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSI-GAMTFFTAslLEDTSIPLVACLFIAGmVVGSTFSLGISYMT 320
Cdd:cd17504 33 VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIyTAGSLLAA--FAPNLPVLIAGRALQG-IGGAVFPLAFALVR 109
|
90 100 110
....*....|....*....|....*....|....*..
gi 757772931 321 DLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFF 357
Cdd:cd17504 110 EEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHL 146
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
99-351 |
5.87e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.44 E-value: 5.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 99 FVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPLieinqalpfMISSALCLLTWVFLFL 178
Cdd:cd17371 91 LILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAL---------LFPLLPPEIAWRVLFL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 179 IKN---------EFPLQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSLNGSF------------PVYG-LRIG 236
Cdd:cd17371 162 LGAlpallvlfiRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGalggyygittwlPSYLtGERG 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 237 LQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRK--LVLGWILSiGAMTFFTASLLEDTSIPLVAcLFIAGMVVGSTFSL 314
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRnnFALFALGS-AISILLYFFLPLSPTLILIL-GFPLGFFASGPFSG 319
|
250 260 270
....*....|....*....|....*....|....*..
gi 757772931 315 GISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGG 351
Cdd:cd17371 320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVG 356
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-147 |
5.98e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 8 RFWILVSLVAISGFSQGMLLPLIAIIFEK-DGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSL 86
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757772931 87 ALFPLWK---SVVFWFVLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVG 147
Cdd:cd17321 249 LLLALLGadsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
235-351 |
8.27e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 37.94 E-value: 8.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 235 IGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSI-GAMTFFTAslLEDTSIPLVACLFIAGMVVGSTFS 313
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLwSLFTALTG--FATSLTSLYVLRFLLGVAEAGFFP 110
|
90 100 110
....*....|....*....|....*....|....*...
gi 757772931 314 LGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGG 351
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG 148
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
20-353 |
8.31e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 37.99 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 20 GFSQGMLLPLIAIIFEKDGLSSTINGLNATGLYLGILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWF 99
Cdd:PRK12307 31 GFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 100 VLRLFIGIGDHALHFGTQTWITSSSPADKRGRNISLYGLFFGIGFAVGPLMTPliEINQALPFMISSALCLLTWVFLFLI 179
Cdd:PRK12307 111 LSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMP--SFAEAYGWRAAFFVGLLPVLLVIYI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 180 KNEFP-LQEVEVNSLKETAKRFSKAAKYAWIAFLPPFGYGFLESSL----------------NGSFPVYGLRIGLQVEFI 242
Cdd:PRK12307 189 RARAPeSKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLcvfivlfsifganwpiFGLLPTYLAGEGFDTGVV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 243 SLLLTSFAVGAIVFQLPLGILSDKLGRK--LVLGWILSIgAMTFFTASLLEDTSIPLVACLFIAGMVVGSTFSLGISYMT 320
Cdd:PRK12307 269 SNLMTAAAFGTVLGNIVWGLCADRIGLKktFSIGLLMSF-LFIFPLFRIPQDNYLLLGACLFGLMATNVGVGGLVPKFLY 347
|
330 340 350
....*....|....*....|....*....|....*..
gi 757772931 321 DLIPTRL--LPTGNL--LCGIAFSIGSLAGPYIGGTF 353
Cdd:PRK12307 348 DYFPLEVrgLGTGLIynLAATSGTFNSMAATWLGITM 384
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
244-363 |
9.06e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.00 E-value: 9.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 244 LLLTSFAVGAIVFQLPLGILSDKLGRKLVLgwilsIGAMTFFTASLLEDTSIPLVACLF----IAGmVVGSTFSLGISYM 319
Cdd:cd17388 42 VLLALYALMQFIFAPILGALSDRFGRRPVL-----LLSLAGAALDYLLMAFAPTLWWLYlgriIAG-ITGATGAVAAAYI 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 757772931 320 TDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGGTFIQFFHHISFF 363
Cdd:cd17388 116 ADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFL 159
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
55-371 |
9.94e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 55 ILFISPFMEAPLRRYGYKPIIAAGGLLVIVSLALFPLWKSVVFWFV-LRLFIGIGdHALHFGTQTWITSSSPADKRGR-- 131
Cdd:cd17352 51 SLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLG-LGLIYSPAIVIVGQYFEKKRGLat 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 132 NISLYGLFFGiGFAVGPLMTPLIE-INQALPFMISSALCLLTWVFLFLIKnefplqevevnSLKETA-KRFSKAAKYAWI 209
Cdd:cd17352 130 GIAVAGSGVG-TFVFPPLLRYLLDnYGWRGALLILGGLCLNLCVCGLLLR-----------LLKDPTfVLLALGVSFAML 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 210 AFLPPFGYgflesslngsFPVYGLRIGLQVEFISLLLTSFAVGAIVFQLPLGILSDKLGRKLVLGWILSIGAMT-FFTAS 288
Cdd:cd17352 198 GFFVPFVY----------LPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGlSLLAF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 289 LLEDTSIPLVACLFIAGMVVGSTFSLGISYMTDLIPTRLLPTGNLLCGIAFSIGSLAGPYIGG-------TFIQFFHHIS 361
Cdd:cd17352 268 PLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGllrdytgDYDAAFYFCG 347
|
330
....*....|
gi 757772931 362 FFNIISGMLC 371
Cdd:cd17352 348 ACLLLSGVLL 357
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
242-381 |
9.99e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 37.82 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757772931 242 ISLLLTSF--AVGAIVFqlplGILSDKLGRKLVLgwILSIGAMTFFTAS-LLEDTSIPLVACLFIAGMVVGSTFSLGISY 318
Cdd:COG2270 278 VFGLLVQIvaALGALLF----GRLDDRIGPKRVI--LVSLVIWIVVCLAaYFLTTALAFWILGLLIGLVMGGIQALSRSL 351
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757772931 319 MtdlipTRLLPTGNL-----LCGIAFSIGSLAGPYIGGTFIQFFHHISFfniisGMLCCifIVLFVFG 381
Cdd:COG2270 352 L-----ARLIPPGREaeffgLYALSGKAASFLGPLLFGLVTQLTGSQRL-----GILSL--IVFFVIG 407
|
|
| |
