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Conserved domains on  [gi|757781687|ref|WP_043000271|]
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MULTISPECIES: porin OmpC [Citrobacter]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
14-393 6.16e-158

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member PRK10554:

Pssm-ID: 473880  Cd Length: 355  Bit Score: 448.52  E-value: 6.16e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  14 LIAGAAHSAEVYNKDGNKLDLYGKVDGLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQWEYNINASGTEGDKgDS 93
Cdd:PRK10554   1 LVAGAANAAEIYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENEN-NS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  94 ATRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTqTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQ 173
Cdd:PRK10554  80 WTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYG-SDNFMQQRGNGFATYRNTDFFGLVDGLNFALQYQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 174 GNNeGASFGQEGSGNStyRKLAQENGDGFGMSTSYDFDFGLSLGAAYSSSDRTDDQVSRGYgdrsrannYAGGETAEAWT 253
Cdd:PRK10554 159 GKN-GSVSGEGMTNNG--RGALRQNGDGYGGSLTYDYGEGFSIGAAISSSKRTDDQNNLAY--------IGNGDRAETYT 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 254 IGAKYDANNIYLATMYAETRNMTYYgggkgeTNGGIANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQDHDGdgnp 333
Cdd:PRK10554 228 GGLKYDANNIYLAAQYTQTYNATRF------GSLGFANKAQNFEVVAQYQFDFGLRPSVAYLQSKGKDLGNINGRN---- 297
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 334 rYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDnDDHFYADNGIATDDIVAVGLVYQF 393
Cdd:PRK10554 298 -YGDQDILKYVDVGATYYFNKNMSTYVDYKINLLD-DNQFTRDAGINTDDIVALGLVYQF 355
 
Name Accession Description Interval E-value
PRK10554 PRK10554
outer membrane porin protein C; Provisional
14-393 6.16e-158

outer membrane porin protein C; Provisional


Pssm-ID: 182543  Cd Length: 355  Bit Score: 448.52  E-value: 6.16e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  14 LIAGAAHSAEVYNKDGNKLDLYGKVDGLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQWEYNINASGTEGDKgDS 93
Cdd:PRK10554   1 LVAGAANAAEIYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENEN-NS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  94 ATRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTqTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQ 173
Cdd:PRK10554  80 WTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYG-SDNFMQQRGNGFATYRNTDFFGLVDGLNFALQYQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 174 GNNeGASFGQEGSGNStyRKLAQENGDGFGMSTSYDFDFGLSLGAAYSSSDRTDDQVSRGYgdrsrannYAGGETAEAWT 253
Cdd:PRK10554 159 GKN-GSVSGEGMTNNG--RGALRQNGDGYGGSLTYDYGEGFSIGAAISSSKRTDDQNNLAY--------IGNGDRAETYT 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 254 IGAKYDANNIYLATMYAETRNMTYYgggkgeTNGGIANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQDHDGdgnp 333
Cdd:PRK10554 228 GGLKYDANNIYLAAQYTQTYNATRF------GSLGFANKAQNFEVVAQYQFDFGLRPSVAYLQSKGKDLGNINGRN---- 297
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 334 rYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDnDDHFYADNGIATDDIVAVGLVYQF 393
Cdd:PRK10554 298 -YGDQDILKYVDVGATYYFNKNMSTYVDYKINLLD-DNQFTRDAGINTDDIVALGLVYQF 355
Porin_1 pfam00267
Gram-negative porin;
27-393 6.84e-152

Gram-negative porin;


Pssm-ID: 395205  Cd Length: 335  Bit Score: 432.25  E-value: 6.84e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   27 KDGNKLDLYGKVDGLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQWEYNINASGTEGDKGDSATRLGFAGLGFGQ 106
Cdd:pfam00267   1 KDGNKLDLYGKVTGLHYFSDRDGSDGDDTYARIGFKGETQINDQLTGYGQWEYNVSVNGTEGASTQWGTRLAFAGLKFGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  107 NGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTQTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQGNNEgasfgqegs 186
Cdd:pfam00267  81 FGSFDYGRNYGVLYDVGAWTDVLPEFGGDTTAQTDNFMTGRANGVATYRNPDFFGLVDGLNFALQYQGKNE--------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  187 gNSTYRKLAQENGDGFGMSTSYDFDFGLSLGAAYSSSDRTDDQVSRGYgdrSRANNYAGGETAEAWTIGAKYDANNIYLA 266
Cdd:pfam00267 152 -DTPARNLTKSNGDGYGVSLNYDNGGGFGYGGAYARSDRTGDQKIEYY---SIASLTGNGKKAEVWRLGGKYDANNIYLA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  267 TMYAETRNMTYYgggkgeTNGGIANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQdhdgdgnprYTDKDLVKYVDV 346
Cdd:pfam00267 228 AAYAQTRNATRY------GAMGFANKTQNTEVVAQYQFDFGLRPSISYAQSKGKDLEGA---------YGDNDLVKYVDV 292
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 757781687  347 GMTYYFNKNMSTYVDYKINLLDNDDhfyaDNGIATDDIVAVGLVYQF 393
Cdd:pfam00267 293 GATYYFNKNMSTYVDYKINLLDKGD----DLGINTDDAVAVGLRYQF 335
OmpC COG3203
Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];
4-393 2.04e-60

Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442436 [Multi-domain]  Cd Length: 336  Bit Score: 198.69  E-value: 2.04e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   4 KVLAMLVPALLiAGAAHSAevynkdgNKLDLYGKVDGLHYFSDNTD------SDGDMSYVRLGFKGETQIMDQLTGYGQW 77
Cdd:COG3203    1 TLLALAVAAAL-AGAAHAQ-------SSVTLYGRVDAGVEYVDNGGgsltrlTSGGDSGSRLGFKGSEDLGGGLKAIFQL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  78 EYNINA-SGTEGDKGDSATRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTQTD--VYMLGRTNGVATY 154
Cdd:COG3203   73 ESGFNAdTGTSGGGGRLFGRQAYVGLKGDDFGTLTLGRQYTPLYDVVGAFDPFGDSGDAGNLAGDdnLAGTGRADNAIKY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 155 RNKGFfgqvDGLNFALQYQGNNEGASFGqegsgnstyrklaqeNGDGFGMSTSYDFDfGLSLGAAYSSSDRTDdqvsrgy 234
Cdd:COG3203  153 RSPNF----GGLTFGAQYSFGEDAGSSS---------------NGRGYGAGLTYANG-PLSLGAAYQQSNDAQ------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 235 gdrsraNNYAGGETAEAWTIGAKYDANNIYLATMYAETRNMTYYGGGkgetnggiANQTKNFEAVAQYQFDFGLRPSIAY 314
Cdd:COG3203  206 ------GATAGGDDADAWGLGASYDFGNLKLAAGYGQTKNDDAGGAG--------NAKADGYELGASYPFGPALTLSASY 271
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757781687 315 LVSKGKElggqdhdgdgnprYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDNDDHFYADNGiATDDIVAVGLVYQF 393
Cdd:COG3203  272 GYTDAKD-------------GADDDDANQYALGADYALSKRTSLYAEYGYNDNDGNANFTAAAG-DTDDGVAVGLRHKF 336
gram_neg_porins cd00342
Porins form aqueous channels for the diffusion of small hydrophillic molecules across the ...
30-393 6.79e-42

Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.


Pssm-ID: 238208 [Multi-domain]  Cd Length: 329  Bit Score: 149.83  E-value: 6.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  30 NKLDLYGKVDGLHYFSDNTDSD-------GDMSYVRLGFKGETQIMDQLTGYGQWEYNIN-ASGTEGDKGDSATRLGFAG 101
Cdd:cd00342    1 SSVTLYGRIDAGVEYVNNAGGGgagqmtsGGNNGSRWGLRGSEDLGGGLKAIFQLESGFNlNTGALGQGGRLFGRQAYVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 102 LGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDS--YTQTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQGNNEGa 179
Cdd:cd00342   81 LSSDTYGTLTLGRQYTPLYDVLGTTDPFGGSGGGSapGDGDNLAGTGRANNSVKYTSPFFGGLTFGAMYAFGNQAGSTS- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 180 sfgqegsgnstyrklaqeNGDGFGMSTSYDFDfGLSLGAAYSSSDRTDDQvsrgygdrsrANNYAGGETAEAWTIGAKYD 259
Cdd:cd00342  160 ------------------NGRGYGAGLSYENG-PLSLGAAYDQQRNGGGA----------AGGAAGATSQRAYGAGASYD 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 260 ANNIYLATMYAETRNMTYYGGGkgetnggiANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQDHDGDgnprytdkd 339
Cdd:cd00342  211 FGGLKLGAGYTNTRNDNGGGGG--------SAKFNGYELGATYQLTPALRLGAAYYYTKDRNDGGGDGKAN--------- 273
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757781687 340 lvkYVDVGMTYYFNKNMSTYVDYKINLLDNDD-----HFYADNGIATDDIVAVGLVYQF 393
Cdd:cd00342  274 ---QVALGADYALSKRTDLYAEYGYQKNSGGAstglaGGGGPSSGNNQDGVAVGIRHKF 329
 
Name Accession Description Interval E-value
PRK10554 PRK10554
outer membrane porin protein C; Provisional
14-393 6.16e-158

outer membrane porin protein C; Provisional


Pssm-ID: 182543  Cd Length: 355  Bit Score: 448.52  E-value: 6.16e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  14 LIAGAAHSAEVYNKDGNKLDLYGKVDGLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQWEYNINASGTEGDKgDS 93
Cdd:PRK10554   1 LVAGAANAAEIYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENEN-NS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  94 ATRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTqTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQ 173
Cdd:PRK10554  80 WTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYG-SDNFMQQRGNGFATYRNTDFFGLVDGLNFALQYQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 174 GNNeGASFGQEGSGNStyRKLAQENGDGFGMSTSYDFDFGLSLGAAYSSSDRTDDQVSRGYgdrsrannYAGGETAEAWT 253
Cdd:PRK10554 159 GKN-GSVSGEGMTNNG--RGALRQNGDGYGGSLTYDYGEGFSIGAAISSSKRTDDQNNLAY--------IGNGDRAETYT 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 254 IGAKYDANNIYLATMYAETRNMTYYgggkgeTNGGIANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQDHDGdgnp 333
Cdd:PRK10554 228 GGLKYDANNIYLAAQYTQTYNATRF------GSLGFANKAQNFEVVAQYQFDFGLRPSVAYLQSKGKDLGNINGRN---- 297
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 334 rYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDnDDHFYADNGIATDDIVAVGLVYQF 393
Cdd:PRK10554 298 -YGDQDILKYVDVGATYYFNKNMSTYVDYKINLLD-DNQFTRDAGINTDDIVALGLVYQF 355
Porin_1 pfam00267
Gram-negative porin;
27-393 6.84e-152

Gram-negative porin;


Pssm-ID: 395205  Cd Length: 335  Bit Score: 432.25  E-value: 6.84e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   27 KDGNKLDLYGKVDGLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQWEYNINASGTEGDKGDSATRLGFAGLGFGQ 106
Cdd:pfam00267   1 KDGNKLDLYGKVTGLHYFSDRDGSDGDDTYARIGFKGETQINDQLTGYGQWEYNVSVNGTEGASTQWGTRLAFAGLKFGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  107 NGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTQTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQGNNEgasfgqegs 186
Cdd:pfam00267  81 FGSFDYGRNYGVLYDVGAWTDVLPEFGGDTTAQTDNFMTGRANGVATYRNPDFFGLVDGLNFALQYQGKNE--------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  187 gNSTYRKLAQENGDGFGMSTSYDFDFGLSLGAAYSSSDRTDDQVSRGYgdrSRANNYAGGETAEAWTIGAKYDANNIYLA 266
Cdd:pfam00267 152 -DTPARNLTKSNGDGYGVSLNYDNGGGFGYGGAYARSDRTGDQKIEYY---SIASLTGNGKKAEVWRLGGKYDANNIYLA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  267 TMYAETRNMTYYgggkgeTNGGIANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQdhdgdgnprYTDKDLVKYVDV 346
Cdd:pfam00267 228 AAYAQTRNATRY------GAMGFANKTQNTEVVAQYQFDFGLRPSISYAQSKGKDLEGA---------YGDNDLVKYVDV 292
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 757781687  347 GMTYYFNKNMSTYVDYKINLLDNDDhfyaDNGIATDDIVAVGLVYQF 393
Cdd:pfam00267 293 GATYYFNKNMSTYVDYKINLLDKGD----DLGINTDDAVAVGLRYQF 335
PRK10159 PRK10159
phosphoporin PhoE;
1-393 3.84e-145

phosphoporin PhoE;


Pssm-ID: 182275  Cd Length: 351  Bit Score: 415.87  E-value: 3.84e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   1 MKRKVLAMLVPALLIAGAAHSAEVYNKDGNKLDLYGKVDGLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQWEYN 80
Cdd:PRK10159   1 MKKSTLALVVMGIVASASVQAAEVYNKDGNKLDVYGKVKAMHYMSDNDSKDGDQSYIRFGFKGETQINDQLTGYGRWEAE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  81 INASGTEGDKGDSATRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTQTDVYMLGRTNGVATYRNKGFF 160
Cdd:PRK10159  81 FAGNKAESDTAQQKTRLAFAGLKYKDLGSFDYGRNLGALYDVEAWTDMFPEFGGDSSAQTDNFMTKRASGLATYRNTDFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 161 GQVDGLNFALQYQGNNEGasfgqegsgnstyRKLAQENGDGFGMSTSYDF---DFGLSlgAAYSSSDRTDDQVSRGYGdr 237
Cdd:PRK10159 161 GVIDGLNLTLQYQGKNEN-------------RDVKKQNGDGFGTSLTYDFggsDFAIS--GAYTNSDRTNEQNLQSRG-- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 238 srannyaGGETAEAWTIGAKYDANNIYLATMYAETRNMTyygggkgETNGGIANQTKNFEAVAQYQFDFGLRPSIAYLVS 317
Cdd:PRK10159 224 -------TGKRAEAWATGLKYDANNIYLATFYSETRKMT-------PISGGFANKTQNFEAVAQYQFDFGLRPSLGYVLS 289
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757781687 318 KGKELGGqdhdgdgnprYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDNDDHFyadnGIATDDIVAVGLVYQF 393
Cdd:PRK10159 290 KGKDIEG----------IGDEDLVNYIDVGATYYFNKNMSAFVDYKINQLDSDNKL----NINNDDIVAVGMTYQF 351
PRK10002 PRK10002
porin OmpF;
1-393 6.41e-137

porin OmpF;


Pssm-ID: 236639  Cd Length: 362  Bit Score: 395.41  E-value: 6.41e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   1 MKRKVLAMLVPALLIAGAAHSAEVYNKDGNKLDLYGKVDGLHYFSDNT-----DSDGDMSYVRLGFKGETQIMDQLTGYG 75
Cdd:PRK10002   2 MKRNILAVIVPALLVAGTANAAEIYNKDGNKVDLYGKAVGLHYFSKGNgensyGGNGDMTYARLGFKGETQINSDLTGYG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  76 QWEYNINASGTEGDKGDSA--TRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSyTQTDVYMLGRTNGVAT 153
Cdd:PRK10002  82 QWEYNFQGNNSEGADAQTGnkTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDT-AYSDDFFVGRVGGVAT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 154 YRNKGFFGQVDGLNFALQYQGNNEGASfgqegsgnstyrkLAQENGDGFGMSTSYDFDfGLSLGAAYSSSDRTDDQVSRG 233
Cdd:PRK10002 161 YRNSNFFGLVDGLNFAVQYLGKNERDT-------------ARRSNGDGVGGSISYEYE-GFGIVGAYGAADRTNLQEAQP 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 234 YGdrsrannyaGGETAEAWTIGAKYDANNIYLATMYAETRNMTYYgGGKGETNGGIANQTKNFEAVAQYQFDFGLRPSIA 313
Cdd:PRK10002 227 LG---------NGKKAEQWATGLKYDANNIYLAANYGETRNATPI-TNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIA 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 314 YLVSKGKELGGqdhdgdgnprYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDNDDHFyadnGIATDDIVAVGLVYQF 393
Cdd:PRK10002 297 YTKSKAKDVEG----------IGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKL----GVGSDDTVAVGIVYQF 362
OmpC COG3203
Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];
4-393 2.04e-60

Outer membrane porin OmpC/OmpF/PhoE [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442436 [Multi-domain]  Cd Length: 336  Bit Score: 198.69  E-value: 2.04e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   4 KVLAMLVPALLiAGAAHSAevynkdgNKLDLYGKVDGLHYFSDNTD------SDGDMSYVRLGFKGETQIMDQLTGYGQW 77
Cdd:COG3203    1 TLLALAVAAAL-AGAAHAQ-------SSVTLYGRVDAGVEYVDNGGgsltrlTSGGDSGSRLGFKGSEDLGGGLKAIFQL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  78 EYNINA-SGTEGDKGDSATRLGFAGLGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTQTD--VYMLGRTNGVATY 154
Cdd:COG3203   73 ESGFNAdTGTSGGGGRLFGRQAYVGLKGDDFGTLTLGRQYTPLYDVVGAFDPFGDSGDAGNLAGDdnLAGTGRADNAIKY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 155 RNKGFfgqvDGLNFALQYQGNNEGASFGqegsgnstyrklaqeNGDGFGMSTSYDFDfGLSLGAAYSSSDRTDdqvsrgy 234
Cdd:COG3203  153 RSPNF----GGLTFGAQYSFGEDAGSSS---------------NGRGYGAGLTYANG-PLSLGAAYQQSNDAQ------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 235 gdrsraNNYAGGETAEAWTIGAKYDANNIYLATMYAETRNMTYYGGGkgetnggiANQTKNFEAVAQYQFDFGLRPSIAY 314
Cdd:COG3203  206 ------GATAGGDDADAWGLGASYDFGNLKLAAGYGQTKNDDAGGAG--------NAKADGYELGASYPFGPALTLSASY 271
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757781687 315 LVSKGKElggqdhdgdgnprYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDNDDHFYADNGiATDDIVAVGLVYQF 393
Cdd:COG3203  272 GYTDAKD-------------GADDDDANQYALGADYALSKRTSLYAEYGYNDNDGNANFTAAAG-DTDDGVAVGLRHKF 336
gram_neg_porins cd00342
Porins form aqueous channels for the diffusion of small hydrophillic molecules across the ...
30-393 6.79e-42

Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.


Pssm-ID: 238208 [Multi-domain]  Cd Length: 329  Bit Score: 149.83  E-value: 6.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  30 NKLDLYGKVDGLHYFSDNTDSD-------GDMSYVRLGFKGETQIMDQLTGYGQWEYNIN-ASGTEGDKGDSATRLGFAG 101
Cdd:cd00342    1 SSVTLYGRIDAGVEYVNNAGGGgagqmtsGGNNGSRWGLRGSEDLGGGLKAIFQLESGFNlNTGALGQGGRLFGRQAYVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 102 LGFGQNGTFDYGRNYGVVYDVEAWTDMLPEFGGDS--YTQTDVYMLGRTNGVATYRNKGFFGQVDGLNFALQYQGNNEGa 179
Cdd:cd00342   81 LSSDTYGTLTLGRQYTPLYDVLGTTDPFGGSGGGSapGDGDNLAGTGRANNSVKYTSPFFGGLTFGAMYAFGNQAGSTS- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 180 sfgqegsgnstyrklaqeNGDGFGMSTSYDFDfGLSLGAAYSSSDRTDDQvsrgygdrsrANNYAGGETAEAWTIGAKYD 259
Cdd:cd00342  160 ------------------NGRGYGAGLSYENG-PLSLGAAYDQQRNGGGA----------AGGAAGATSQRAYGAGASYD 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 260 ANNIYLATMYAETRNMTYYGGGkgetnggiANQTKNFEAVAQYQFDFGLRPSIAYLVSKGKELGGQDHDGDgnprytdkd 339
Cdd:cd00342  211 FGGLKLGAGYTNTRNDNGGGGG--------SAKFNGYELGATYQLTPALRLGAAYYYTKDRNDGGGDGKAN--------- 273
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757781687 340 lvkYVDVGMTYYFNKNMSTYVDYKINLLDNDD-----HFYADNGIATDDIVAVGLVYQF 393
Cdd:cd00342  274 ---QVALGADYALSKRTDLYAEYGYQKNSGGAstglaGGGGPSSGNNQDGVAVGIRHKF 329
OM_channels cd01345
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
149-387 5.52e-33

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


Pssm-ID: 238655 [Multi-domain]  Cd Length: 253  Bit Score: 124.08  E-value: 5.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 149 NGVATYRNKGFFGQVDGLNFALQYQGNNEGASFGQEGSGNstyRKLAQENGDGFGMSTSYDFDFGLSLGAAYSSSDRTDD 228
Cdd:cd01345    8 NPVLNIRQGLGQTPDDDLTLK*GYARANKAPSLYQTNPGN---DDAKAETSDGKEIGLEFKRDGGWLAGVTYARNDYTNK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 229 QVSRGYGDRSRAN-------NYAGGETAEAWTIGAKYDAN-NIYLATMYaetrnmTYYGGGKGETNGGIANQTKNFEAVA 300
Cdd:cd01345   85 IEAGYVAVGQNAVgtdlyqwDNVPKAVVEGLEGSLNVPVSeTV*WTNNY------TY*LKSENKTTRLSIIPEYTLNVTL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 301 QYQFDFGLRPSIAYLVSKGKELGGqdhdgdgnprYTDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLdnDDHFYADNGIA 380
Cdd:cd01345  159 SWQAREDLS*QVTYTWYKKQQPKK----------YKEIDPYSIVGLSATWDVTKNVSLTGGYDNLFD--KRLWRAGNAQT 226

                 ....*..
gi 757781687 381 TDDIVAV 387
Cdd:cd01345  227 TGDANYI 233
Porin_4 pfam13609
Gram-negative porin;
12-273 4.62e-06

Gram-negative porin;


Pssm-ID: 433346 [Multi-domain]  Cd Length: 311  Bit Score: 47.82  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   12 ALLIAGAAHSAEvynkdgnKLDLYGKVD-GLHYFSDNTDSDGDMSYV------RLGFKGETQIMDQLTGYGQWEYNinas 84
Cdd:pfam13609   5 LAAAAGAAAAQS-------SVTLYGSADaGVGYVNGGAAGAGADGETgldsnsRIGFGGSEELDNGLGFGASFELE---- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687   85 GTEGDKGDSATRLGFAGLGfGQNGTFDYGRNYGVVYDVEAWTDM-LPEFGGDSYTQTDVYMLGRTNGVATYRNKGFFGQV 163
Cdd:pfam13609  74 AGFNGAGGFNNRQAYVGLS-GGFGTVTLGRQDGAFDEAGVDYDFdGGSLGDSGYDGSGLSGSAGFDGRDSNSIIYYSPKF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  164 DGLNFALQYQGNNEGASFGQEGSGNSTYrklaqENGDGFGMSTSYDF-DFGLSLGAAYSSSDRTDDQVSR---------- 232
Cdd:pfam13609 153 GGFTAGASYAFGEDGNTNGNNGGVAGDS-----NDTDGYGLGAGYDFgGVGFSVAAAYQQTDNEGGDQDAwglgasyslg 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 757781687  233 -----GYGDRSRANNYAGGETAEAWTIGAKYDANNIYLATMYAETR 273
Cdd:pfam13609 228 aftlgASYADIDDDGAAAGADDNGYGVGATYTVGALTVGAAYGRYD 273
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
25-363 5.09e-03

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 39.04  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687  25 YNKDGNKLDLYGKvdgLHYFSDNTDSDGDMSYVRLGFKGETQIMDQLTGYGQweyNINASGTEGDKGDSATRLGFaglgf 104
Cdd:COG1629  252 YEHLGDGLKLSAS---AYYRYDDTDLDSDFTPTPADGGTLEQTDFDNRTYGL---ELRLTYDLGFGGKHTLLVGL----- 320
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 105 gqngTFDYGRNYGVVYDVEAWTDMLPEFGGDSYTQTDvymlgrtngvatYRNKGFFGQVD---GLNFALQYQGNNEGASF 181
Cdd:COG1629  321 ----DYQRQDLDGSGYPLDLGSGSLPTLTSGADDDGT------------TTSLALYAQDTyklTDKLTLTAGLRYDYVSY 384
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 182 GQEGSGNSTYRKLAQENGDGFG--MSTSYDFDFGLSLGAAYSSSDRT---DDQVSRGYGDRSRANNYAGGETAEAWTIGA 256
Cdd:COG1629  385 DVDDTVTGTDSASGSRSYSAFSpsLGLTYQLSPNLSLYASYSRGFRAptfGELYANGTDPYSVGNPDLKPETSTNYELGL 464
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757781687 257 KYDANN----IYLATMYAETRNM--TYYGGGKGETNGGIAN----QTKNFEAVAQYQFDFGLRPSIAYLVSKGKelggQD 326
Cdd:COG1629  465 RYRLLDgrlsLSLALFYSDVDNEilSVPLPNDSGFSTYYTNagkaRSYGVELELSYQLTPGLSLNASYSYTDAK----FD 540
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 757781687 327 HDGDGNPRYTDKDLVK----YVDVGMTYYFNKNMSTYVDYK 363
Cdd:COG1629  541 DDTDGSADLDGNRLPGvpplTANLGLTYEFPGGWSLGLGVR 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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