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Conserved domains on  [gi|757782241|ref|WP_043000825|]
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MULTISPECIES: amino acid ABC transporter permease [Citrobacter]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-220 2.05e-51

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 165.63  E-value: 2.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   1 MIANIAVITDNLDYLLwgrladgqpGGVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVI 80
Cdd:COG0765    1 MFFDFSVLLDYLPLLL---------EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  81 FWMWYLLPMLtGSDLPGAATVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLT 160
Cdd:COG0765   72 FFIYFGLPLL-GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 161 GICIGLLKDTSLAFIVNVPELTTVAGQVNSREQiYPAAIFIFTGLVYYLLCYGLEKATRR 220
Cdd:COG0765  151 NEFISLLKDTSLVSVIGVPELTRAAQQIASRTF-RPFEVYLVAALIYLVLTLPLSLLARR 209
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-220 2.05e-51

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 165.63  E-value: 2.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   1 MIANIAVITDNLDYLLwgrladgqpGGVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVI 80
Cdd:COG0765    1 MFFDFSVLLDYLPLLL---------EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  81 FWMWYLLPMLtGSDLPGAATVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLT 160
Cdd:COG0765   72 FFIYFGLPLL-GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 161 GICIGLLKDTSLAFIVNVPELTTVAGQVNSREQiYPAAIFIFTGLVYYLLCYGLEKATRR 220
Cdd:COG0765  151 NEFISLLKDTSLVSVIGVPELTRAAQQIASRTF-RPFEVYLVAALIYLVLTLPLSLLARR 209
PRK15100 PRK15100
cystine ABC transporter permease;
27-211 3.07e-18

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 79.79  E-value: 3.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  27 GVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLtGSDLPGAATVTLALA 106
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF-GIELDPIPAAMIGLS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 107 WFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIVNVPELTTVAG 186
Cdd:PRK15100  97 LNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQ 176

                        170       180
                 ....*....|....*....|....*.
gi 757782241 187 QVNSRE-QIYpaAIFIFTGLVYYLLC 211
Cdd:PRK15100 177 LITSRTlEVF--TMYLAASLIYWIMA 200
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 29-210 6.16e-12

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.91  E-value: 6.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  29 LLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLTGSDLP---GAATVTLAL 105
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 106 AWFtAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIVNVPELTTvA 185
Cdd:cd06261   82 LLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG-P 159

                        170       180
                 ....*....|....*....|....*
gi 757782241 186 GQVNSREQIYPAAIFIFTGLVYYLL 210
Cdd:cd06261  160 GTGLLLIFAILFPGDLGVAAAVALI 184
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 27-111 9.12e-08

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 48.68  E-value: 9.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   27 GVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPmLTGSDLPGAATVTLALA 106
Cdd:TIGR01726   8 GLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLP-LIGIRLSPLTAAVIALT 86


                  ....*
gi 757782241  107 WFTAA 111
Cdd:TIGR01726  87 LFYGA 91
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 42-211 1.33e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.21  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   42 ALPAGIALAAlawRFPGVIRKGLFIWAELIRGIP--LIFVIFWMWYLLPMLTGSDLPGAAtvtlALAWFTAASVMHSVYA 119
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPsfVLAILLVVIAILSILGHGILPAII----LALLGWAGYARLIRRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  120 GLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLA-FIVNVPELTTVAGQVNSREQI-YPA 197
Cdd:pfam00528  74 ALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLeFLGSWPGLGLLLIEAILGYDYpEIQ 153

                         170
                  ....*....|....
gi 757782241  198 AIFIFTGLVYYLLC 211
Cdd:pfam00528 154 GPVLAAALILLLLN 167
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-220 2.05e-51

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 165.63  E-value: 2.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   1 MIANIAVITDNLDYLLwgrladgqpGGVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVI 80
Cdd:COG0765    1 MFFDFSVLLDYLPLLL---------EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  81 FWMWYLLPMLtGSDLPGAATVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLT 160
Cdd:COG0765   72 FFIYFGLPLL-GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 161 GICIGLLKDTSLAFIVNVPELTTVAGQVNSREQiYPAAIFIFTGLVYYLLCYGLEKATRR 220
Cdd:COG0765  151 NEFISLLKDTSLVSVIGVPELTRAAQQIASRTF-RPFEVYLVAALIYLVLTLPLSLLARR 209
PRK15100 PRK15100
cystine ABC transporter permease;
27-211 3.07e-18

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 79.79  E-value: 3.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  27 GVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLtGSDLPGAATVTLALA 106
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF-GIELDPIPAAMIGLS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 107 WFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIVNVPELTTVAG 186
Cdd:PRK15100  97 LNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQ 176

                        170       180
                 ....*....|....*....|....*.
gi 757782241 187 QVNSRE-QIYpaAIFIFTGLVYYLLC 211
Cdd:PRK15100 177 LITSRTlEVF--TMYLAASLIYWIMA 200
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
34-207 1.52e-13

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 67.39  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  34 MALGAAVLALPAGIALAAL-------AWRFpgvIRKGLFIWAELIRGIPLIFVIFWMWY----LLPMLTGSDLPGAATVT 102
Cdd:PRK11123  13 MTVGLAVCALIVGLALAMLfavwesaKWRP---VAWPGTALVTLLRGLPEILVVLFIYFgssqLLLTLSDGFTLNLGFVQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 103 LALAWFT-------------AASVMHSVYA------GLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGIC 163
Cdd:PRK11123  90 IPVQMDIenfevspflcgviALSLLYAAYAsqtlrgALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQW 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 757782241 164 IGLLKDTSLAFIVNVPELTTVAGQVNSREQiYPAAIFIFTGLVY 207
Cdd:PRK11123 170 LVLLKDTALVSLISVNDLMLQTKSIATRTQ-EPFTWYIIAAAIY 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 29-210 6.16e-12

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.91  E-value: 6.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  29 LLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLTGSDLP---GAATVTLAL 105
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 106 AWFtAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIVNVPELTTvA 185
Cdd:cd06261   82 LLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG-P 159

                        170       180
                 ....*....|....*....|....*
gi 757782241 186 GQVNSREQIYPAAIFIFTGLVYYLL 210
Cdd:cd06261  160 GTGLLLIFAILFPGDLGVAAAVALI 184
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
27-210 8.11e-12

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 62.54  E-value: 8.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  27 GVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLTGSDLPGAA------- 99
Cdd:PRK15107  19 GLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPktdirli 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 100 TVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIVNVP 179
Cdd:PRK15107  99 SAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLA 178

                        170       180       190
                 ....*....|....*....|....*....|.
gi 757782241 180 ELTTVAGQVNSREQIYPAAIfIFTGLVYYLL 210
Cdd:PRK15107 179 DFFRTASTIGERDGTQVEMI-LFAGFVYFVI 208
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 6-182 1.44e-11

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 61.61  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   6 AVITDNLDYLLwgrlaDGQPGGVLLTLMMALGAAVLALPAGIALAALAWrfpgVIRKGLFIWAELIRGIPLIFVIFWMWY 85
Cdd:PRK09494   6 SAIWPAIPLLL-----EGAKMTLWISVLGLAGGLVIGLLAGFARAYGGW----IANHIALVFIELIRGTPIVVQVMFIYF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  86 LLPMLTGS---DLPGAATVTLALAwfTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGI 162
Cdd:PRK09494  77 ALPMAFNDlriDPFTAAVVTIMIN--SGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQ 154

                        170       180
                 ....*....|....*....|
gi 757782241 163 CIGLLKDTSLAFIVNVPELT 182
Cdd:PRK09494 155 WIISIKDTSLFIVIGVAELT 174
artM PRK11122
arginine ABC transporter permease ArtM;
11-207 1.54e-11

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 61.51  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  11 NLDYLLwgRLADGQPGGVLLTLMMALGAAVLALpagIALAALAWRFPgVIRKGLFIWAELIRGIPL---IFVIF------ 81
Cdd:PRK11122   1 MLEYLP--ELLKGLHTSLTLTVASLLVALVLAL---IFTIILTLKTP-VLVWLVRGYITLFTGTPLlvqIFLIYygpgqf 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  82 -------WMWYLLpmltgSDLPGAATVTLALAwfTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRrVLLPQVLRH 154
Cdd:PRK11122  75 pwlqeypWLWHLL-----SQPWLCAMLALALN--SAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKR 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 757782241 155 ILPSLTGICIGLLKDTSLAFIVNVPELTTVAGQVNSREqiYPAAIFIFTGLVY 207
Cdd:PRK11122 147 ALSSYSNEVVLVFKSTSLAYTITLMDVMGYSQLLYGRT--YDVMVFGAAGIIY 197
PRK15069 PRK15069
histidine ABC transporter permease HisM;
29-220 3.13e-10

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 58.14  E-value: 3.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  29 LLTLMMALGAaVLALPAGIALAAlAWRFpgvIRKGLFIWAELIRGIPL---IFVIFWMWYLLPMLTGSDL------PGAA 99
Cdd:PRK15069  29 LLVASVVIGF-VLAVPLAIARVS-SNKW---IRFPVWLYTYVFRGTPLyvqLLVFYTGMYSLEIVRGTDLldaffrSGLN 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 100 TVTLALAWFTAAsVMHSVYAG-LNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIVNV 178
Cdd:PRK15069 104 CTILAFTLNTCA-YTTEIFAGaIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATV 182

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 757782241 179 PELTTVAGQVNSrEQIYPAAIFIFTGLVYYLLCYGLEKATRR 220
Cdd:PRK15069 183 PDILKIARDINS-ATYQPFQAFGIAAVLYLIISFVLISLFRR 223
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 27-111 9.12e-08

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 48.68  E-value: 9.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   27 GVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPmLTGSDLPGAATVTLALA 106
Cdd:TIGR01726   8 GLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLP-LIGIRLSPLTAAVIALT 86


                  ....*
gi 757782241  107 WFTAA 111
Cdd:TIGR01726  87 LFYGA 91
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
27-207 2.53e-07

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 49.79  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  27 GVLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLTGS----------DLP 96
Cdd:PRK15135  12 GALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNSvtealgvgqiDID 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  97 GAATVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIV 176
Cdd:PRK15135  92 PMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLL 171

                        170       180       190
                 ....*....|....*....|....*....|.
gi 757782241 177 NVPELTTvAGQVNSREQIYPAAIFIFTGLVY 207
Cdd:PRK15135 172 GLEDVVK-ATQLAGKSTWEPFYFAIVCGVIY 201
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
31-220 8.33e-07

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 49.00  E-value: 8.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  31 TLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWAELIRGIP-----LIFVIFWMWYLLPMLTGSdlpgAATVTLAL 105
Cdd:COG1178  343 SLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPgivlgLGLLLLFNRPLPLLLYGT----LAILVLAY 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241 106 AWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLAFIV---NVPELT 182
Cdd:COG1178  419 VVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLrppGFETLA 498

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 757782241 183 TVAGQVNSREQIYPAAIF-IFTGLVYYLLCYGLEKATRR 220
Cdd:COG1178  499 VLIYQLASSGRYGEAAALaLLLVLVSLLPVLLLERLLGR 537
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 32-156 2.07e-06

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 46.97  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  32 LMMALGAAVLALPAGIALAALAWRFPGViRKGLFIWAELIRGIPLIFVIFwmwyLLPMLTGsdlPGAATVTLALAWFTAA 111
Cdd:COG1174   24 LLLVLLALLIALLIAVPLGILITRRRRL-AGLVLGVANILQTIPSLALLA----LLIPLLG---IGPAPAIIALVLYALL 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 757782241 112 SVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHIL 156
Cdd:COG1174   96 PILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVIL 140
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 28-159 6.41e-06

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 45.52  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  28 VLLTLMMALGAAVLALPAGIALAALAWRFPgVIRKGLFIWAELIRGIPLIFVIFwmwyLLPMLTGSDLPGAATVTLALAW 107
Cdd:COG0600   63 LLASLLRVLLGFALAALLGVPLGLLLGLSR-LLRRLLDPLLVFLRPIPPLALAP----LLILWFGIGEASKIFVIFLGAF 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 757782241 108 FTAASvmhSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSL 159
Cdd:COG0600  138 FPILL---NTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGL 186
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 42-211 1.33e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.21  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241   42 ALPAGIALAAlawRFPGVIRKGLFIWAELIRGIP--LIFVIFWMWYLLPMLTGSDLPGAAtvtlALAWFTAASVMHSVYA 119
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPsfVLAILLVVIAILSILGHGILPAII----LALLGWAGYARLIRRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  120 GLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLLKDTSLA-FIVNVPELTTVAGQVNSREQI-YPA 197
Cdd:pfam00528  74 ALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLeFLGSWPGLGLLLIEAILGYDYpEIQ 153

                         170
                  ....*....|....
gi 757782241  198 AIFIFTGLVYYLLC 211
Cdd:pfam00528 154 GPVLAAALILLLLN 167
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
16-160 1.01e-04

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 42.84  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  16 LWGRLADGQPGGVLL-TLMMALGAAVLALPAGIALAALAWR--FPGvirKGLFIWAELIrgiPLI---------FVIF-- 81
Cdd:COG1178   43 FWALLSDPYLWRALGnTLLLALLVTLLSLLLGVPLAWLLARtdFPG---RRLLRWLLLL---PLAlppyvvalaWIALfg 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  82 ---WMWYLLPMLTGSDLP---GAATVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHI 155
Cdd:COG1178  117 pngLLNTLLRALFGLEPPdiyGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAI 196


                 ....*
gi 757782241 156 LPSLT 160
Cdd:COG1178  197 AAGAL 201
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 28-152 8.48e-04

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 39.32  E-value: 8.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  28 VLLTLMMALGAAVLALPAGIALAALAWRFPGVIRKGLFIWA-------ELIRGIPLIFvifwMWYLLPMLtgsdlPGAAT 100
Cdd:COG1177   63 LLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLllplvvpGIVLGVALLL----LFSALGLS-----GGLWG 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 757782241 101 VTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVL 152
Cdd:COG1177  134 LILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA 185
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
27-167 2.53e-03

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 37.79  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782241  27 GVLLTLMMALGAA----VLALPAGIALAALAwrfPG------VIRKGLFIWAELIRGIPLIFVIFWMWYLLPMLTGSDLp 96
Cdd:PRK10782  12 GVWETLAMTFVSGffgfVIGLPVGVLLYVTR---PGqiianaKLYRTLSALVNIFRSIPFIILLVWMIPFTRVIVGTSI- 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757782241  97 GAATVTLALAWFTAASVMHSVYAGLNALPAGQYDAAVAQGFSPVQALRRVLLPQVLRHILPSLTGICIGLL 167
Cdd:PRK10782  88 GLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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