|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
14-394 |
8.14e-166 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 470.29 E-value: 8.14e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 14 AVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFF 93
Cdd:cd17396 1 TALGLYFNYFVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 94 GIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIP 173
Cdd:cd17396 81 GILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 174 GILFVLITLMLLRSQFPGQLV--DASVAKELPQMNSKPLVWLEGVASVMFGVAAFSTFYVIVVWMPKYAMAFAGMEEADA 251
Cdd:cd17396 161 AAVLVLNALLLLKLSFPPQTVtaANTKQKEIPVKREKPKFLIEGIALILIGFTSTATFYLFSQWMPKYGSAVAGMGEAES 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 252 LKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSE 331
Cdd:cd17396 241 LKLISYYSMGSLVCVFITAVLLKRYVRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLGLTLMAE 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757782269 332 FFPKSKAKVTSVYMMMGGLANFVIPLITGYL-STIGLQYIILLDFAFALLAFITGIIVFVRYYR 394
Cdd:cd17396 321 FFPKGKGKVTGIYMIASSLANFVIPLITGIIaSAIGIAYIFLFDFGIALLGLLLAIFVFIRYRK 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
19-383 |
1.85e-40 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 147.47 E-value: 1.85e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 19 YLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPAS 98
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 99 PNLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIPGILFV 178
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 179 LITLMLLRSQFPgQLVDASVAKELPQMNSKPLVWLEGVASVMFGVAAFSTFYV----IVVWMPKYAMAFAGMEEADALKT 254
Cdd:cd17333 162 LLAILILLTLFP-ELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGaetaFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 255 ITYYSLGSLVCVFIFAALLKKMVrpIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFP 334
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIK--PHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 757782269 335 KSKAKVTSVYMMMGGLANFVIPLITGYL-STIGLQYIILLDFAFALLAFI 383
Cdd:cd17333 319 YAKGKGTSVLLAAGSIGGAIIPFIMGFIaEAVGIQTAMLLITILYAIIFV 368
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-388 |
9.71e-29 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 116.11 E-value: 9.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 13 LAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFF 92
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 93 FGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNI--WYGYGV 170
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 171 IIPGILFVLITLMLLRSQFPGQLVD----ASVAKELPQMNSKPLVWLeGVASVMFGVAAFSTFYvivVWMPKYAMAFAGM 246
Cdd:COG0738 168 LILAVLLLLLALLFLRSKLPEIEEEeeeaAGSAASLKSLLKNPRLLL-GGLAIFLYVGAEGAIG---DWLPLYLKDVLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 247 EEADALKTITYYSLGSLVCVFIFAALLKKmVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAgGILQLGV 326
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS-LMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782269 327 SVMSEFFPKSKAKVTSVYMMMGGLANFVIPLITGYLS-TIGLQYIILLDFAFALLAFITGIIV 388
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-394 |
9.70e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 81.07 E-value: 9.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 12 FLAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILF 91
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 92 FFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYG--Y 168
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAafL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 169 GVIIPGILFVLITLMLLrsqfpgqlvdasvakelpqmnskplvwlegvasVMFGVAAFSTFYVIVVWMPKYAMAFAGMEE 248
Cdd:COG2271 169 ILGLPGLLLALLRFWLL---------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 249 ADALKTITYYSLGSLVCVFIFAALLKKMVRP-IWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFsAAGGILQLGVS 327
Cdd:COG2271 216 AQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF-GLGGAFGLLWA 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757782269 328 VMSEFFPKSK-AKVTSVYMMMGGLANFVIPLITGYL-STIGLQYIILLDFAFALLAFITGIIVFVRYYR 394
Cdd:COG2271 295 LAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLlDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-352 |
1.31e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.40 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 13 LAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFF 92
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 93 FGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYG--YG 169
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWvfLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 170 VIIPGILFVLITLMLLRSQFPGQlvDASVAKELPQMNSKPLVWLegvaSVMFGVAAFSTFYVIVVWMPKYAMAFAGMEEA 249
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAA--RARLRGSLRELLRRPRLLL----LLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 250 DALKTITYYSLGSLVCVFIFAALLKKMVRPIWAnVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVM 329
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLL-LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|...
gi 757782269 330 SEFFPKSKAKVTSVYMMMGGLAN 352
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-394 |
3.81e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.54 E-value: 3.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 36 MTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVAN 115
Cdd:COG2223 28 APPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 116 SALDTGGYPALMECFPK-----ASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIpGILFVLITLMLLRSQFP 190
Cdd:COG2223 108 GGSFAVGIALVSKWFPPdrrglALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILL-LVVAVLAWLFLRDPPAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 191 GQLVDASVAKELPQMNSKPLVWLegvASVMFgVAAFSTFYVIVVWMPKYAMAFAGMEEADALKTITYYSLGSLVCVFIFA 270
Cdd:COG2223 187 AAAAAKASLRDQLEALRDPRFWL---LSLLY-FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 271 ALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGL 350
Cdd:COG2223 263 WLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 757782269 351 ANFVIPLITGYLSTIGLQYIILLdFAFALLAFITGIIVFVRYYR 394
Cdd:COG2223 343 GGFLGPLLFGALLDATGSYTAAF-LVFAVLALVALVLTLLLYRR 385
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
19-335 |
1.91e-14 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 74.19 E-value: 1.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 19 YLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPAS 98
Cdd:PRK03699 13 FLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 99 PNLMV----AFVLAVCVGVansALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIPG 174
Cdd:PRK03699 93 HSLALfsiaMFVLGVVSGI---TMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIEWYWVYACIG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 175 ILFVLITLMLLRSQFPgQLVDASVAKELPQMNSK--PLVWLEGVASVMFGVAAfstfYVIVVWMPKYAMAFAGMEEADAL 252
Cdd:PRK03699 170 LVYVAIFILTLFSEFP-ALGKHAPKADKPVAKEKwgIGVLFLAIAALLYILAQ----LTFISWVPEYAQKKFGMSLEDAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 253 KTITYYSLGSLVCVFIFAALLKKMvRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAG---GILQLGVSVM 329
Cdd:PRK03699 245 NLVSNFWMAYMVGMWIFSFIVRFF-DLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSSAiytTIITLGSQQT 323
|
....*.
gi 757782269 330 SEFFPK 335
Cdd:PRK03699 324 KVASPK 329
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-356 |
3.03e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.52 E-value: 3.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 18 IYLSYFLHGISVITLAQNMTS-LAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIP 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 97 ASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKA-SGSAVILVKAMVSFGQMLYPMLVGYMLLNNIW-YGYGVIIPG 174
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWrAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 175 ILFVLITLMLLRSQFPGQLVDASVAKELPQMNSKPLVWLEGVASVMFG-VAAFSTFYVIVVWMPKYAMAFaGMEEADALK 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAlLLFGFAFFGLLTYLPLYQEVL-GLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 254 TITYYSLGSLVCVFIFAALLKKM--VRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSE 331
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 757782269 332 FFPKSKAKVTSVYMMMGGLANFVIP 356
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-383 |
9.65e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.99 E-value: 9.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 18 IYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPA 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 98 SPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVS-----FGQMLYPMLVGYMLLNNIWYGYGVII 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGsvggiLGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 173 PGILFVLITLMLLRSQFPGQLVDASVAKELPQMNSKPLVWLEG--VASVMFGVAAFSTFYVIVVWMPKYAMAFAGMEEAD 250
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPglWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 251 ALKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMS 330
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 757782269 331 EFFPKSKAKVTSVYMMMGGLANFVIPLITGYLS--TIGLQYIILLDFAFALLAFI 383
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLTGAFLVLAVLLLLAAI 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-388 |
1.16e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.58 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 12 FLAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILF 91
Cdd:COG2807 17 WLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 92 FFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIW-YGYGV 170
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWrGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 171 -IIPGILFVLITLMLLRSQfPGQLVDASVAKELPQMNSKPLVWLegvASVMFGVAAFsTFYVIVVWMPKYAMAfAGMEEA 249
Cdd:COG2807 177 wALLALLALLLWLPLLRRR-PAAAAAAPAAASLRSLWRSPLAWL---LTLFFGLQSL-LYYAVVAWLPPILRD-AGLSAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 250 DALKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCnAGAFVIGFsAAGGILQLGVSVM 329
Cdd:COG2807 251 TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGL-GQGGLFPLALTLI 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782269 330 SEFFPKSK--AKVTSVYMMMGGLANFVIPLITGYL--STIGLQYIILLDFAFALLAFITGIIV 388
Cdd:COG2807 329 GLRARTPAeaAALSGMAQSVGYLLAALGPLLVGALhdATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-391 |
2.38e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.82 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 50 IAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMEC 129
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 130 FPKASGSAVI-LVKAMVSFGQMLYPMLVGYMLL---NNIWYGYGVIIPGILFVLITLmllrsqfPGQLVDASVAKELPQM 205
Cdd:cd17473 117 FEGEERAKMLgLQSAAMSLGGVVFLLLGGALAEigwRAPFLVYLLALPVLILVLLFL-------PEPARKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 206 NSKPLVWLEGVASVMFGVAAFSTFYVIVVWMPKYAMAFAGMEEADALKTITYYSLGSLVcVFIFAALLKKMVRPIWANVF 285
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAI-GALLFGRLKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 286 NAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLANFVIPLITGYLSTI 365
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|....*.
gi 757782269 366 GLQYIILLDFAFALLAFITGIIVFVR 391
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-383 |
8.75e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 8.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 18 IYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPA 97
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 98 SPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYMLlnnIWYGYGV--IIPG 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEErGRAMGIFSSAIGLGFLIGPLLGGLLA---DALGYRApfLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 175 ILFVLITLMLLRSQFPGQLVDASVAKELPQMNSKPLVWLEGVASVMFGVAAFSTFYVIVVW---MPKYAMAFAGMEEADA 251
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepfLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 252 LKTITYYSLGSLVCVFIFAALLKKMVRPIWAnVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSE 331
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 757782269 332 FFPKSKAKVTSVYMMMGGLANFVIPLITGYLS-TIGLQYIILLDFAFALLAFI 383
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAV 369
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-186 |
3.64e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 57.59 E-value: 3.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 59 LGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECF-PKASGSA 137
Cdd:cd17317 36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVgPKYRSFV 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 757782269 138 VILVKAMVSFGQMLYPmLVGYMLLNNIWYGYGVIIPGILFVLITLMLLR 186
Cdd:cd17317 116 GILFGLFWALGYMLLA-LLAYLIRDWRWLQLAISLPGLLFLLLLWWLPR 163
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-292 |
3.95e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.51 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 13 LAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFF 92
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 93 FGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYMLLNNIW-YGYGV 170
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWrWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 171 IIPGILFVLITLMLLRSQFPGQLVDASVAKELPQMNSKPLVWLEGVASVMFGVAAFSTFYVIVVWMPKYAMAFAGMEEAD 250
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 757782269 251 ALKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATV 292
Cdd:COG0477 254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-383 |
1.01e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.79 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 36 MTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVAN 115
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 116 SALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYM--LLNNIWYGYGVIIPGILFVLITLMLLRSQFPGQ 192
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKrGRAIGLVFSGLTLGLVLGRPLGGLLgqLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 193 LVDASVAKELPQMNSKPLVWLeGVASVMFGVAAFSTFYvivVWMPKYAMAFAGMEEADALKTITYYSLGSLVCVFIFAAL 272
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRL-AYLITFLLFGGFFALY---TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 273 LKKMVRPIWAnVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFsAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLAN 352
Cdd:cd17324 258 ADRGGRRALL-IALLLLAAALLLLTLLGPSPLLLLVGLVLWGL-GFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGG 335
|
330 340 350
....*....|....*....|....*....|..
gi 757782269 353 FVIPLITGY-LSTIGLQYIILLDFAFALLAFI 383
Cdd:cd17324 336 ALGAALGGLvLDHGGWAGVGWVGAALLLLALL 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-386 |
1.65e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.07 E-value: 1.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 15 VICIYLSYFLHGISVITLAQNMTSLAAKFS--TDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFF 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 93 FGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVII 172
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 173 PGILFVLITLMLLrsqfpgqlvdasvakelpqmnskpLVWLEGVASVMFGVAAFSTFYVIVVWMPKYAMAFAGMEEADAL 252
Cdd:cd17316 161 LFLIGALPALLAL------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 253 KTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEF 332
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 757782269 333 FPKS-KAKVTSVYMMMGGLANFVIPLITGYL--STIGLQYIILLDFAFALLAFITGI 386
Cdd:cd17316 297 FPTEvRATGVGLSYNLGRLGGGGAPPLIALLlaSTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-383 |
2.55e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 37 TSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANS 116
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 117 ALDTGGYPALMECFP-KASGSAVILVKAMVSFGQMLYPMLVGymLLNNIWYGY---GVIIPGILFVLITLMLLRSQF-PG 191
Cdd:cd17474 103 GLGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGG--LLAAISWRYpffLLAALIPVAFLAILFLLPEPKeKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 192 QLVDASVAKELPQMNSKPLVWLEGVASVMFgvaaFSTFYVIVVWMPKYAMAFAGMEEADALKTITYYSLGSLVCVFIFAA 271
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLY----FFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 272 LLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLA 351
Cdd:cd17474 257 LLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
330 340 350
....*....|....*....|....*....|...
gi 757782269 352 NFVIPLITGYL-STIGLQYIILLDFAFALLAFI 383
Cdd:cd17474 337 QAVGPLLFGLLlEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
18-120 |
6.43e-08 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 54.19 E-value: 6.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 18 IYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPA 97
Cdd:cd17393 4 VAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGL 83
|
90 100
....*....|....*....|...
gi 757782269 98 SPNLMVAFVLAVCVGVANSALDT 120
Cdd:cd17393 84 APSVPALALALFLFGAANGALDV 106
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-185 |
1.55e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 13 LAVICIYLSYFLHGISVITLAQNMTS-LAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILF 91
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPFlLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 92 FFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKA-SGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGV 170
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPElRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF 356
|
170
....*....|....*
gi 757782269 171 IIPGILFVLITLMLL 185
Cdd:cd17473 357 LILGVLALVLAIVLL 371
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
12-335 |
2.59e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 52.24 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 12 FLAVICIYLSYFLhGISVITLAQNMTSLAAKFSTdsAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILF 91
Cdd:cd17345 5 FLGIFIGYAGYYL-VRNNFSLAQPYLIEQYGLSK--TEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 92 FFGIPASPNLMVAFVLAVCVGVANSALDTGGYPA----LMECFP-KASGSAVILVKAMVSFGQMLYPMLV--GYMLLNNI 164
Cdd:cd17345 82 NILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPsgrtMVHWFSkKERGTWTSIWNISHNVGGGLVGPLAglGLAIFGDG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 165 WYGYGVIIPGILFVLITLMLLRSQ---------------FPGQLVDASVAKELPQMNSK----------PLVWLEGVASV 219
Cdd:cd17345 162 WWRGAFIFPAIIAIIVAVIVLFLGkdtpeseglppieeyKGDYPEEADGEEEEQELSAWeifvkyvlknKLLWYIAIANV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 220 mfgvAAFSTFYVIVVWMPKYAMAFAGMEEADALKTITYYSL----GSLVCVFIfAALLKKMVRPIWANVFnagLATVTAA 295
Cdd:cd17345 242 ----FVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWaaipGTLLAGWL-SDKLFKGRRAPTGIIF---MILVIVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 757782269 296 VIYLW--PSPLVCNAGAFVIGFSAAGGILQLGVSVMsEFFPK 335
Cdd:cd17345 314 LIVYWlaPNVLVDLIALIALGFLIYGPVMLIGLQAL-ELVPK 354
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-186 |
3.22e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.81 E-value: 3.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 39 LAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSAL 118
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757782269 119 DTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYmLLNNIWYGYGVIIPGILFVLITLMLLR 186
Cdd:cd17325 306 FPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
36-384 |
6.67e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.04 E-value: 6.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 36 MTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVAN 115
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 116 SALDTGGYPALMECFPKASGSAVI-LVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIPGILFVLITLMLLR-----SQF 189
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFsLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFlpetlPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 190 PGQLVDASVAKELPQMNSKPLVWLeGVASVMFGVAAFSTFYVivvwmpkyAMAFAGMEEADALKTITYYSLGSLVCVFIF 269
Cdd:cd17320 182 KRKPLLSSLLRAYKRVLKNRRFLG-YALALGLSFAGLFAYLA--------AAPFIYIEQLGLSPAQFGLLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 270 AALLKKMVRPIW--------ANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVT 341
Cdd:cd17320 253 GSLLNGRLVRRFgprrllrlGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTAS 332
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 757782269 342 SVYMMMGGLANFVIPLITGYLSTIGLQYIILLDFAFALLAFIT 384
Cdd:cd17320 333 ALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
36-389 |
7.58e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 36 MTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVAN 115
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 116 SALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYmLLNNIWYGYGVIIPGILFVLITLMLLRSQFPGQLVD 195
Cdd:cd17478 99 AAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA-LVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 196 ASVAKELPQMNSKPLVWleGVASVMFGVAAFSTFYV--IVVWMPKYAMAfAGMEEADALKTITYYSLGSLVCVFIFAALL 273
Cdd:cd17478 178 KKAAAKSSARSTLKGVW--RALLLLLIIVFLRSWVLssLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 274 KKMVRpiwANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLANF 353
Cdd:cd17478 255 DRFGR---RRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGG 331
|
330 340 350
....*....|....*....|....*....|....*..
gi 757782269 354 VIPLITGYLS-TIGLQYIILldfAFALLAFITGIIVF 389
Cdd:cd17478 332 IGAPVLGALAdAFGLESVLL---ILALLPLLGALLAF 365
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-362 |
2.05e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.30 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 19 YLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPAS 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 99 PNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGY---MLLNNIWYGYGVIIPG 174
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVLFgiaELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 175 ILFVLITLMLLRS-----------QFPGQLVDASVAKELPQMNSK----------PLVWLEGVASVmfgvAAFSTFYVIV 233
Cdd:TIGR00881 161 IIVSLICFLLLRDspqscglppaeEMPNEEPDGDAEKKEEELTKKqiflqyvllnKVLWYISLGYV----FVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 234 VWMPKYAMAFAGMeeaDALKTITYYSL-------GSLVCVFIFAALLKKMVRPIwaNVFNAGLATVTAAVIYLWP--SPL 304
Cdd:TIGR00881 237 DWSPLYLTQEKGF---SKEKASWAFTLyelgglvGTLLAGWLSDKLFNGRRGPL--AVFFMALIIVSLLVYWLNPaaNPL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 757782269 305 VCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLANFVIPLITGYL 362
Cdd:TIGR00881 312 MDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-391 |
2.69e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 10 PFFLAVICIYLSYFLHGISVITLAQNMTSLAAKFSTdsAGIAYLISGIGLGrlvsiLFFGVLSDKFGRRAI-----ILLG 84
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGL--VLAAFFLPFLLFS-----PFAGVLADRFDRRRLliladLLRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 85 AALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYML-LN 162
Cdd:cd06173 76 LLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQlVRANALNSLATQLARIIGPALGGLLVaLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 163 NIWYGYGVIIPGILFVLITLMLLRSQFPGQLVDASVAKELPQMNSKPLVWLEGVASVMFGVAAFSTFYVIVVWMPKYAMA 242
Cdd:cd06173 156 GPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 243 FAGMEEADALKTITY--YSLGSLVcVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGG 320
Cdd:cd06173 236 KEVLGGGAAGYGLLLaaFGVGALL-GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757782269 321 ILQLGVSVMSEFFPKSKAKVTSVYMMMGGLANFVIPLITGYLS-TIGLQYIILLdfaFALLAFITGIIVFVR 391
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAdALGLSAVFLL---AGALLLLAALLLLLL 383
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
12-364 |
2.94e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.73 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 12 FLAVICIYLSYFLHGISVITLaqnMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILF 91
Cdd:cd17312 5 FLGVFLGYAAYYVCRKNFSVA---KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 92 FFGIPASPNLMVAFVLAVCVGVANSAldtgGYPALMECF-----PKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWy 166
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSM----GWPPCVKLLgnwfsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGW- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 167 GYGVIIPGI---LFVLITLMLLRsqfpgqlvdasvakelpqmNSKPLVWLEGVASvmfgVAAFSTFYVIVVWMPKYAMAF 243
Cdd:cd17312 157 RAAFLVPGIvglVVAIILFFFLR-------------------DSPPYVWVLSLAY----AFVYIVRYACLDWGPLYLYEV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 244 AGMEEADALKTITYYSLGSLVCVFIFAALLKKMV--RPIWANVFNAGLATVTAAVIYLWPSPLVCNAGA-FVIGFSAAGG 320
Cdd:cd17312 214 KGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFggRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLlFLIGFFVGGP 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 757782269 321 ILQLGVsVMSEFFPKSKA--KVTSVYMMMGGLANFVIPLITGYLST 364
Cdd:cd17312 294 INLIGG-AAAQDIGRKEAagTATGFVGLFGYLGASLAGLPLGYIID 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-362 |
3.58e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.69 E-value: 3.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 39 LAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSAL 118
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 119 DTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGyGVIIPG---ILFVLITLMLLRSQFPGQLV 194
Cdd:cd17475 102 QPGGGRAIMRWFPPRErGLAMGIRQTGVPLGGALAAALLPPLALHYGWRA-AFVVAGlvsILAAVLFWLFYREPPAASAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 195 DAS---VAKELPQMNSKPLVWLEGVASV--MFGVAAFSTFYVIvvwmpkYAMAFAGMEEADALKTITYYSLGSLVCVFIF 269
Cdd:cd17475 181 TESastLLRSLKEVLRNRDVWLIAIAGAllVAPQFALLTFLLL------FLHDHLGLSVVAAGALLAVAQLGGALGRIGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 270 AALLKKM-----VRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAG--GilqLGVSVMSEFFPKSKA-KVT 341
Cdd:cd17475 255 GRVSDRVfggrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnG---LYLTLVAESAGPEQAgTAL 331
|
330 340
....*....|....*....|.
gi 757782269 342 SVYMMMGGLANFVIPLITGYL 362
Cdd:cd17475 332 GLANTINFIGIAIGPPLFGLL 352
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-383 |
3.62e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.76 E-value: 3.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 19 YLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPAS 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 99 PNLMVAFVLAVCVGVANSALDTGGYPALMECFP-KASGSAVILVKAMVSFG----QMLYPMLVGYMLLNNIWYG--YGVI 171
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPaRHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVlfLLGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 172 IPGILFVLITLML------LRSQFPGQLVDASVAKELPQmnSKPLVWLEGVASVMFGVAAFsTFYVIVVWMPKYAMAFAG 245
Cdd:cd17371 165 LPALLVLFIRRFVkeppqwQAARAARRHFADRPSLRELF--SPPLLRTTLLASLLATGALG-GYYGITTWLPSYLTGERG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 246 MEEADALKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSaAGGILQLG 325
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFF-ASGPFSGM 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 326 VSVMSEFFPKS-KAKVTSVYMMMGGLANFVIPLITGYLST-IGLQYIILLDFAFALLAFI 383
Cdd:cd17371 321 GAYLTELFPTAvRATAQGFCYNVGRIIGALFPFLVGFLATsGSLGTAIAVFAAVYYIAGL 380
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
60-181 |
5.39e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.97 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 60 GRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALME-CFPKASGSAV 138
Cdd:cd17374 47 GLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEwTTPRHRALAI 126
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 757782269 139 ILVKAMVSFGQMLYPmLVGYMLLNNIWYGYGVIIPGILFVLIT 181
Cdd:cd17374 127 TLTSCFFSIGQMLLA-GLAYAIRDWRLLQLVVSVPFFLFFLYS 168
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-184 |
6.13e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 46 DSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPA 125
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 757782269 126 LMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIPGILFVLITLML 184
Cdd:cd17324 312 VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
60-184 |
1.59e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 43.61 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 60 GRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKA----SG 135
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSywalAG 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 757782269 136 SAVILVKAMvsfGQMLYPMLvGYMLLNNIWYGYGVIIPGILFVLITLML 184
Cdd:cd17377 131 SLGGLFFAV---GIAQYALL-GYFIRSWRTLAVVVNLQGTLVFLLSLFI 175
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
12-131 |
1.88e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.28 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 12 FLAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISgiglgrLVSILFFGVLSDKFGRRAIILLGAALYILF 91
Cdd:cd17369 234 IGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVA------AITIPLFGWLSDRVGRRPVYLAGALLAALF 307
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 757782269 92 FFGIPA---SPNLMVAFVLAVCVGVANSALDTGGYPALM-ECFP 131
Cdd:cd17369 308 AFPFFWlldTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLaELFP 351
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-362 |
2.55e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 13 LAVICIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFF 92
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 93 FGIPASPNLMVAFVLAVCVGVANSaldtGGYPALME-----CFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYG 167
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLG----GLMPNLNAlvseyAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 168 ---YGVIIPGILFVLITLML------LRSQFPGQL----------VDASVAKELPQMNSKPLVWLEGVASVMFGVAAFST 228
Cdd:TIGR00895 173 lfyVGGIAPLLLLLLLMRFLpesidfLVSKRPETVrrivnaiapqMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 229 -------------FYVIVVWMPKYaMAFAGMEEADALKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAA 295
Cdd:TIGR00895 253 vllwllyfmllvgVYFLTNWLPKL-MVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLV 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757782269 296 VIYLWPSPLVCNAGAFViGFSAAGGILQLGVSvMSEFFPkSKAKVTSVYMM--MGGLANFVIPLITGYL 362
Cdd:TIGR00895 332 GSTLFSPTLLLLLGAIA-GFFVNGGQSGLYAL-MALFYP-TAIRATGVGWAigIGRLGAIIGPILAGYL 397
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-179 |
2.70e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 59 LGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPALMECFP-KASGSA 137
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPkKQRAIV 217
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 757782269 138 VILVKAMVSFGQMLYPmLVGYMLLNNIWYGYGVIIPGILFVL 179
Cdd:TIGR00898 218 GTLIQVFFSLGLVLLP-LVAYFIPDWRWLQLAVSLPTFLFFL 258
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
1-111 |
4.27e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 1 MSQNKAFSTPFFLaviCIYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGI-----GLGRLvsilFFGVLSDKF 75
Cdd:cd17353 204 YTPREMLRTPTFW---LLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSIlsifnGGGRP----FWGWLSDKI 276
|
90 100 110
....*....|....*....|....*....|....*.
gi 757782269 76 GRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCV 111
Cdd:cd17353 277 GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVAL 312
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
38-383 |
5.87e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.78 E-value: 5.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 38 SLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMV----AFVLAVCVGV 113
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIfiiaRIIGGLAVGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 114 ANSALdtggyPALM-ECFPKAS-GSAVILVKAMVSFGQMLyPMLVGYMLLN---NIWYGYGV--------IIPGILFVLI 180
Cdd:cd17359 106 ASALV-----PMYIaEVAPAEIrGRLVSLNQLMIVFGQLL-AYIVNYLIANaggADWLGAEGwrwmlgleAIPAILFLLG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 181 TLMLLRSqfPGQLVdasvakelpqMNSKPLVWlegvasVMFGVAAFSTFYVIVVWMpKYA---MAFAGMEEADALKTITY 257
Cdd:cd17359 180 MLFIPES--PRWLV----------SKGKPILI------IGIGLAIFQQFVGINVIF-YYGpeiFQNAGFSENAALLQTIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 258 YSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVS-------VMS 330
Cdd:cd17359 241 IGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSwgpvtwvLLS 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 757782269 331 EFFP-KSKAKVTSVYMMMGGLANFVIPLITGYL-STIGLQYIILLDFAFALLAFI 383
Cdd:cd17359 321 EIFPnRIRGLAMGIAVFFLWIANFLVSLTFPILlAAFGLAFTFLIFAVICVLAFL 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-386 |
6.86e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 6.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 47 SAGIAYLISGI-GLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSALDTGGYPA 125
Cdd:cd17489 29 SEAVAGLVVGLfTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 126 LMECFPKA-SGSAVILVKAMVSFGQMLYPMLVGYMLLnniWYGYGVIIPGILFVLITLMLLRSQFPGQLVDASVAKELPQ 204
Cdd:cd17489 109 VADIIPPSrRGEGIGYYGLATTLAMALGPALGLFLYQ---HLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 205 MNSKPLVWLEGVASVMFGVAAFSTFYVIVVWMPKYAMAFAGmeeADALKTITYYSLGSLVCVFIFAALLKKmVRPIWANV 284
Cdd:cd17489 186 RAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLLSRPFSGKLSDR-KGPKTVII 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 285 FNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLANFVIPLITGYLST 364
Cdd:cd17489 262 PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
330 340
....*....|....*....|...
gi 757782269 365 I-GLQYIILLDFAFALLAFITGI 386
Cdd:cd17489 342 LfGYRAMFLLAAVVVLLALVLYI 364
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
36-392 |
6.91e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 6.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 36 MTSLAAKFSTDSAGIAYLISGI--GLGRLVSIL---FFGVLSDKFG-----RRAIILLGAALYILFFFGIPASPN----- 100
Cdd:COG2211 29 LSAYLLYFYTDVLGLSAALVGLilLVARLWDAItdpLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDlsptg 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 101 -LMVAFVLAVCVGVANSALDTGGYPALMECFP------KASGSAVILVKAMVSFGQMLYPMLVGYMLLNNI----WYGYG 169
Cdd:COG2211 109 kLIYALVTYLLLGLAYTLVNIPYSALGAELTPdyeertRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAlgyrLTALI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 170 VIIPGILFVLITLMLLRSQFPGQLVDASVAKELPQ-MNSKPLVWLegVASVMFGVAAFSTFYVIVVWMPKYAMafaGMEE 248
Cdd:COG2211 189 FAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKAlLKNRPFLLL--LLAYLLFFLALALVAALLLYYFKYVL---GLSA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 249 ADALKTITYYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSV 328
Cdd:COG2211 264 ALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 329 MSEFFPKSKAK--------VTSVYMMMGGLANFVIPLITGYLSTIG------------LQYIILLDFAFALLAFITGIIV 388
Cdd:COG2211 344 LADVVDYDEWKtgrrreglYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALL 423
|
....
gi 757782269 389 FVRY 392
Cdd:COG2211 424 LLFY 427
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
38-186 |
8.16e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.22 E-value: 8.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 38 SLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANSA 117
Cdd:TIGR00710 30 EIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASA 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 118 LDTGGYPALMECFPKASGSAVI-LVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIPGILFVLITLMLLR 186
Cdd:TIGR00710 110 GSVISQALVRDIYPGEELSRIYsILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
59-184 |
1.03e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 59 LGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGVANS-ALDTGGYPALMECFPKASGSA 137
Cdd:cd17323 45 LGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSsPLAIGAGTIADLFTPEERGKA 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 757782269 138 VILVKAMVSFGQMLYPMLVGYMLLNNIW---YGYGVIIPGILFVLITLML 184
Cdd:cd17323 125 MGVYSLGPLLGPALGPIIGGFITQSLGWrwiFWFLAIISGFCLILIFLFL 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-382 |
1.14e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 18 IYLSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPA 97
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 98 SPNLMVAFVLAVCVGVANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMLYPMLVGYMlLNNIWYGYGVIIPGIL 176
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENrGRVLGLYSTVLGLGFALGPLLLALV-GTAGALPFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 177 FVLITLMLLRSQFPgqlvDASVAKELPQMNSKPLVWLEGVASVMFGVAAFStfyvIVVWMPKYAMAfAGMEEADALKTIT 256
Cdd:cd17477 160 LALVPLLLTRRAAP----EIEEAESISLRRLLRIAPLALLGAFVAGFLEGA----FYSLLPLYGLR-LGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 257 YYSLGSLVCVFIFAALLKKMVRPIWANVFNAGLATVTAAVIYLWPSPLVCNAGAFVIGfSAAGGILQLGVSVMSEFFPKS 336
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWG-GAAGPLYTLALALAGDRLPGD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 757782269 337 K-AKVTSVYMMMGGLANFVIPLITG----YLSTIGLQYIILLDFAFALLAF 382
Cdd:cd17477 310 ElVAANAALLLLYGLGSVIGPLLAGalmdAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
12-114 |
2.07e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 40.25 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 12 FLAVICIYLSYFLHGISV----ITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAAL 87
Cdd:cd17358 1 LLATFVANLGSFSFGIAVgwssPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110
....*....|....*....|....*....|.
gi 757782269 88 YILFFFGIPASPNLMVA----FVLAVCVGVA 114
Cdd:cd17358 81 CILGWLLIAFAKDVWMLylgrFLAGFGGGAA 111
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-190 |
4.34e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.15 E-value: 4.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 18 IYLSYFLHGISVITLAQNMTSLAAKFSTDSAgIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPA 97
Cdd:cd06179 3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 98 SPNLMVAFVLAVCVGVAnSALDTGGYPALMECFP-KASGSAVILVKAMVSFGQMLYPMLVGYMLLNNI----WYGYgviI 172
Cdd:cd06179 82 AKSVNMLIGGQALIGIG-AGTQGLGAAVASELVPnKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagwrWIFY---I 157
|
170
....*....|....*...
gi 757782269 173 PGILFVLITLMLLRSQFP 190
Cdd:cd06179 158 NAIFNALALILLFFFYHP 175
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
20-187 |
4.47e-03 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 39.05 E-value: 4.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 20 LSYFLHGISVITLAQNMTSLAAKFSTDSAGIAYLISGIGLGRLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASP 99
Cdd:cd17395 4 SVFFSFGLSIAFLGPTLLDLACNTNSSLPQISWVFFSRQLGYLLGSALGGVFKRTLNSLWALFTSSLLIALVLAVIPFCK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 100 NLMVAFVLAVCVGVANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMLYPMLVGYMLLNNIWYGYGVIIPGILFVL 179
Cdd:cd17395 84 DVKVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPFLSYAYWIMALINLPVPMAVL 163
|
....*...
gi 757782269 180 ITLMLLRS 187
Cdd:cd17395 164 MLLSKERL 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
39-186 |
5.38e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 39 LAAKFSTDSAGIAYLISGIGLG-----RLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPASPNLMVAFVLAVCVGV 113
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLAlsavaGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757782269 114 ANSALDTGGYPALMECFPKASGSAVI-LVKAMVSFGQMLYPMLVGYMLLNNiwYGYGVIIPGILFVLITLMLLR 186
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFsLLYWAINLGVAIGPLLGGLLLLYS--FRLLFLAAAVLFLLAALVLLF 172
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
205-383 |
9.17e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.03 E-value: 9.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 205 MNSKPLVWLEGVASVMFGVAAFST-FYVIVVWMPKYAMAFaGMEEADALKTITYYSLGSLVCVFIFAALLKKmVRPIWAN 283
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLgIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 284 VFNAGLATVTAAVIYLWPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSVYMMMGGLANFVIPLITGYL- 362
Cdd:COG2814 79 LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLa 158
|
170 180
....*....|....*....|.
gi 757782269 363 STIGLQYIILLDFAFALLAFI 383
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALL 179
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
44-185 |
9.46e-03 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 38.04 E-value: 9.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782269 44 STDSAGIAYLISGIGLgrLVSILFFGVLSDKFGRRAIILLGAALYILFFFGIPA-----SPNLMVAFVLAVCVGVANSAl 118
Cdd:PRK10489 50 STLQVGLSVTLTGGAM--FIGLMVGGVLADRYDRKKLILLARGTCGLGFIGLALnaflpEPSLLAIYLLGLWDGFFGSL- 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782269 119 dtgGYPALMECFPKASG-----SAVILVKAMVSFGQMLYPMLVGYML-LNNIWYGYGVIIPGILFVLITLMLL 185
Cdd:PRK10489 127 ---GVTALLAATPALVGrenlmQAGAITMLTVRLGSVISPALGGLLIaAGGVAWNYGLAAAGTFITLLPLLRL 196
|
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