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Conserved domains on  [gi|757782295|ref|WP_043000879|]
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MULTISPECIES: type V toxin-antitoxin system endoribonuclease antitoxin GhoS [Citrobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GhoS super family cl12641
Endoribonuclease GhoS; GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT ...
 7-91 2.60e-42

Endoribonuclease GhoS; GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT is inhibited by antitoxin GhoS, which specifically cleaves its mRNA.


The actual alignment was detected with superfamily member pfam11080:

Pssm-ID: 431644  Cd Length: 87  Bit Score: 133.04  E-value: 2.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782295   7 TRYVVTITFHEDSLTEINELNNHLTRAGFLLTLTDDDGNVHELGTNTFGLISAQSPDEVKALAAGLAESALDKMPEVSVV 86
Cdd:pfam11080  1 TRYVVSVTFHEDYLTEINELNNHLTRMGFLLTLTDEEGIPHELGTNTFGLTSSQSAEEIKALIAGLAESALDKDFEINIM 80


                 ....*
gi 757782295  87 TWDEW 91
Cdd:pfam11080 81 TWEEW 85
 
Name Accession Description Interval E-value
GhoS pfam11080
Endoribonuclease GhoS; GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT ...
 7-91 2.60e-42

Endoribonuclease GhoS; GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT is inhibited by antitoxin GhoS, which specifically cleaves its mRNA.


Pssm-ID: 431644  Cd Length: 87  Bit Score: 133.04  E-value: 2.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782295   7 TRYVVTITFHEDSLTEINELNNHLTRAGFLLTLTDDDGNVHELGTNTFGLISAQSPDEVKALAAGLAESALDKMPEVSVV 86
Cdd:pfam11080  1 TRYVVSVTFHEDYLTEINELNNHLTRMGFLLTLTDEEGIPHELGTNTFGLTSSQSAEEIKALIAGLAESALDKDFEINIM 80


                 ....*
gi 757782295  87 TWDEW 91
Cdd:pfam11080 81 TWEEW 85
 
Name Accession Description Interval E-value
GhoS pfam11080
Endoribonuclease GhoS; GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT ...
 7-91 2.60e-42

Endoribonuclease GhoS; GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT is inhibited by antitoxin GhoS, which specifically cleaves its mRNA.


Pssm-ID: 431644  Cd Length: 87  Bit Score: 133.04  E-value: 2.60e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782295   7 TRYVVTITFHEDSLTEINELNNHLTRAGFLLTLTDDDGNVHELGTNTFGLISAQSPDEVKALAAGLAESALDKMPEVSVV 86
Cdd:pfam11080  1 TRYVVSVTFHEDYLTEINELNNHLTRMGFLLTLTDEEGIPHELGTNTFGLTSSQSAEEIKALIAGLAESALDKDFEINIM 80


                 ....*
gi 757782295  87 TWDEW 91
Cdd:pfam11080 81 TWEEW 85
YCII pfam03795
YCII-related domain; The majority of proteins in this family consist of a single copy of this ...
 8-71 6.71e-04

YCII-related domain; The majority of proteins in this family consist of a single copy of this domain, though it is also found as a repeat. A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function. This family also now includes the family formerly known as the DGPF domain (COG3795). Although its function is unknown it is found fused to a sigma-70 factor family domain in Swiss:Q9A8M4. Suggesting that this domain plays a role in transcription initiation (Bateman A per. obs.). This domain is named after the most conserved motif in the alignment.


Pssm-ID: 397734  Cd Length: 94  Bit Score: 35.41  E-value: 6.71e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757782295   8 RYVVTITFHEDSLTEINEL-------NNHLTRAGFLLT---LTDDDGNVHELGTNT--FGLISAQSPDEVKALAAG 71
Cdd:pfam03795  1 LYAILAYDKPASLEERAALraahlayLEQLKKEGVLLAsgpTLVIDGPFAETKEQLggFYIIEAADLDEAIAIAAG 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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