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Conserved domains on  [gi|757782862|ref|WP_043001446|]
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MULTISPECIES: alpha/beta fold hydrolase [Citrobacter]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-278 5.49e-56

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 179.43  E-value: 5.49e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   1 MSQYDKITLkDGSYLYFKDWGDrSGQPIVFSHGWPLTADAFEDQMFFLgSKGYRVIAHDRRGHGRSAQPWEGHTMDQYAD 80
Cdd:COG0596    1 MSTPRFVTV-DGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  81 DLAELTAHLNLQNAVHVGHSTGGGeVARYIGRHGTQRVAKAVLIGAVtpimvktdfnpngvpkevfdgiregvvndraaf 160
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGM-VALELAARHPERVAGLVLVDEV--------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 161 fyeltaafygynrpgakeSKAVRESFVEQGLqgSIKALYDCIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLEtCGKV 240
Cdd:COG0596  124 ------------------LAALAEPLRRPGL--APEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPA-LARR 182

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 757782862 241 AAEILPDAQLKVYAGGSHGICTTHKQQINQDLLNFIQS 278
Cdd:COG0596  183 LAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-278 5.49e-56

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 179.43  E-value: 5.49e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   1 MSQYDKITLkDGSYLYFKDWGDrSGQPIVFSHGWPLTADAFEDQMFFLgSKGYRVIAHDRRGHGRSAQPWEGHTMDQYAD 80
Cdd:COG0596    1 MSTPRFVTV-DGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  81 DLAELTAHLNLQNAVHVGHSTGGGeVARYIGRHGTQRVAKAVLIGAVtpimvktdfnpngvpkevfdgiregvvndraaf 160
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGM-VALELAARHPERVAGLVLVDEV--------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 161 fyeltaafygynrpgakeSKAVRESFVEQGLqgSIKALYDCIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLEtCGKV 240
Cdd:COG0596  124 ------------------LAALAEPLRRPGL--APEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPA-LARR 182

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 757782862 241 AAEILPDAQLKVYAGGSHGICTTHKQQINQDLLNFIQS 278
Cdd:COG0596  183 LAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 27-258 9.25e-32

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 117.61  E-value: 9.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   27 PIVFSHGWPLTADAFEDQMFFLGSKGYRVIAHDRRGHGRSAQPWEGH--TMDQYADDLAELTAHLNLQNAVHVGHSTGGG 104
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDdyRTDDLAEDLEYILEALGLEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  105 EVARYIGRHgTQRVAKAVLIGAVTPIMVKTDFNPNGVPK--EVFDGIREGVVNDRAAFFY--ELTAAFYGYNRPGAKESK 180
Cdd:pfam00561  82 IALAYAAKY-PDRVKALVLLGALDPPHELDEADRFILALfpGFFDGFVADFAPNPLGRLVakLLALLLLRLRLLKALPLL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757782862  181 AVRESFVEQGLQGSIKALYD-CIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLETCGKvAAEILPDAQLKVYAGGSH 258
Cdd:pfam00561 161 NKRFPSGDYALAKSLVTGALlFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEK-LAQLFPNARLVVIPDAGH 238
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 3-258 6.78e-15

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 73.82  E-value: 6.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   3 QYDKITLkDGSYLYFKDWGDRSGQPIVFSHG-------WPLTADAFedqmfflgSKGYRVIAHDRRGHGRSAQPWEGHTM 75
Cdd:PRK14875 110 APRKARI-GGRTVRYLRLGEGDGTPVVLIHGfggdlnnWLFNHAAL--------AAGRPVIALDLPGHGASSKAVGAGSL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  76 DQYADDLAELTAHLNLQNAVHVGHSTGGGEVARYIGRHgTQRVAKAVLIGavtpimvktdfnPNGVPKEVFDGIREGVV- 154
Cdd:PRK14875 181 DELAAAVLAFLDALGIERAHLVGHSMGGAVALRLAARA-PQRVASLTLIA------------PAGLGPEINGDYIDGFVa 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 155 -NDRAAFFYELTAAFygynrpgAKESKaVRESFVE--------QGLQGSIKALYDciKAFSE----TDLREDLRKMTIPT 221
Cdd:PRK14875 248 aESRRELKPVLELLF-------ADPAL-VTRQMVEdllkykrlDGVDDALRALAD--ALFAGgrqrVDLRDRLASLAIPV 317

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 757782862 222 LVIHGDDDQIVPLetcgkVAAEILPD-AQLKVYAGGSH 258
Cdd:PRK14875 318 LVIWGEQDRIIPA-----AHAQGLPDgVAVHVLPGAGH 350
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-278 5.49e-56

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 179.43  E-value: 5.49e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   1 MSQYDKITLkDGSYLYFKDWGDrSGQPIVFSHGWPLTADAFEDQMFFLgSKGYRVIAHDRRGHGRSAQPWEGHTMDQYAD 80
Cdd:COG0596    1 MSTPRFVTV-DGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  81 DLAELTAHLNLQNAVHVGHSTGGGeVARYIGRHGTQRVAKAVLIGAVtpimvktdfnpngvpkevfdgiregvvndraaf 160
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGM-VALELAARHPERVAGLVLVDEV--------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 161 fyeltaafygynrpgakeSKAVRESFVEQGLqgSIKALYDCIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLEtCGKV 240
Cdd:COG0596  124 ------------------LAALAEPLRRPGL--APEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPA-LARR 182

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 757782862 241 AAEILPDAQLKVYAGGSHGICTTHKQQINQDLLNFIQS 278
Cdd:COG0596  183 LAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 27-258 9.25e-32

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 117.61  E-value: 9.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   27 PIVFSHGWPLTADAFEDQMFFLGSKGYRVIAHDRRGHGRSAQPWEGH--TMDQYADDLAELTAHLNLQNAVHVGHSTGGG 104
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDdyRTDDLAEDLEYILEALGLEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  105 EVARYIGRHgTQRVAKAVLIGAVTPIMVKTDFNPNGVPK--EVFDGIREGVVNDRAAFFY--ELTAAFYGYNRPGAKESK 180
Cdd:pfam00561  82 IALAYAAKY-PDRVKALVLLGALDPPHELDEADRFILALfpGFFDGFVADFAPNPLGRLVakLLALLLLRLRLLKALPLL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757782862  181 AVRESFVEQGLQGSIKALYD-CIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLETCGKvAAEILPDAQLKVYAGGSH 258
Cdd:pfam00561 161 NKRFPSGDYALAKSLVTGALlFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEK-LAQLFPNARLVVIPDAGH 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
7-278 3.17e-31

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 115.48  E-value: 3.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   7 ITLKDGSYLYFKDWG--DRSGQPIVFSHGWPLTADAFEDQMFFLGSKGYRVIAHDRRGHGRSAQPwEGH--TMDQYADDL 82
Cdd:COG2267    8 LPTRDGLRLRGRRWRpaGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGP-RGHvdSFDDYVDDL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  83 AELTAHLNLQNAVHV---GHSTGGGEVARYIGRHGtQRVAKAVLIGavtpimvktdfnpngvPKEVFDgireGVVNDRAA 159
Cdd:COG2267   87 RAALDALRARPGLPVvllGHSMGGLIALLYAARYP-DRVAGLVLLA----------------PAYRAD----PLLGPSAR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 160 FFYELTaafygynrpgakeskavresfveqglqgsikalydcikafsetdLREDLRKMTIPTLVIHGDDDQIVPLETCGK 239
Cdd:COG2267  146 WLRALR--------------------------------------------LAEALARIDVPVLVLHGGADRVVPPEAARR 181

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 757782862 240 VAAEILPDAQLKVYAGGSHGICT-THKQQINQDLLNFIQS 278
Cdd:COG2267  182 LAARLSPDVELVLLPGARHELLNePAREEVLAAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 28-260 1.31e-20

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 87.65  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   28 IVFSHGWPLTADAFEDQMFFLGSKGYRVIAHDRRGHGRSaqpwEGHTM-----DQYADDLAELTAHLNLQNA----VHVG 98
Cdd:pfam12146   7 VVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRS----DGKRGhvpsfDDYVDDLDTFVDKIREEHPglplFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   99 HSTGGGEVARYIGRHGtQRVAKAVLIGAvtpiMVKtdfnpngvpkevfdgiregVVNDRAAFFYELTAAFYGYNRPGAKE 178
Cdd:pfam12146  83 HSMGGLIAALYALRYP-DKVDGLILSAP----ALK-------------------IKPYLAPPILKLLAKLLGKLFPRLRV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  179 S-----------KAVRESFVEQGL---QGSIKALYDCIKAFSetDLREDLRKMTIPTLVIHGDDDQIVPLETCGKVAAEI 244
Cdd:pfam12146 139 PnnllpdslsrdPEVVAAYAADPLvhgGISARTLYELLDAGE--RLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERA 216

                         250
                  ....*....|....*..
gi 757782862  245 -LPDAQLKVYAGGSHGI 260
Cdd:pfam12146 217 gSTDKTLKLYPGLYHEL 233
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
28-276 5.74e-15

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 72.36  E-value: 5.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  28 IVFSHGWPLTADAFEDQMF-FLGSKGYRVIAHDRRGHGRSAQPWEGhtmdQYADDLAELTAHLNLQNAVH------VGHS 100
Cdd:COG1506   26 VVYVHGGPGSRDDSFLPLAqALASRGYAVLAPDYRGYGESAGDWGG----DEVDDVLAAIDYLAARPYVDpdrigiYGHS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 101 TGGGEVARYIGRHgTQRVAKAVLIGAVTPIMvktdfnpngvpkevfdgiregvvnDRAAFFYELTAAFYGynrpgakesk 180
Cdd:COG1506  102 YGGYMALLAAARH-PDRFKAAVALAGVSDLR------------------------SYYGTTREYTERLMG---------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 181 avresfveqglqgsikALYDCIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLETCGKVAAEIL---PDAQLKVYAGGS 257
Cdd:COG1506  147 ----------------GPWEDPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKkagKPVELLVYPGEG 210

                        250
                 ....*....|....*....
gi 757782862 258 HGICTTHKQQINQDLLNFI 276
Cdd:COG1506  211 HGFSGAGAPDYLERILDFL 229
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 3-258 6.78e-15

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 73.82  E-value: 6.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   3 QYDKITLkDGSYLYFKDWGDRSGQPIVFSHG-------WPLTADAFedqmfflgSKGYRVIAHDRRGHGRSAQPWEGHTM 75
Cdd:PRK14875 110 APRKARI-GGRTVRYLRLGEGDGTPVVLIHGfggdlnnWLFNHAAL--------AAGRPVIALDLPGHGASSKAVGAGSL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  76 DQYADDLAELTAHLNLQNAVHVGHSTGGGEVARYIGRHgTQRVAKAVLIGavtpimvktdfnPNGVPKEVFDGIREGVV- 154
Cdd:PRK14875 181 DELAAAVLAFLDALGIERAHLVGHSMGGAVALRLAARA-PQRVASLTLIA------------PAGLGPEINGDYIDGFVa 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 155 -NDRAAFFYELTAAFygynrpgAKESKaVRESFVE--------QGLQGSIKALYDciKAFSE----TDLREDLRKMTIPT 221
Cdd:PRK14875 248 aESRRELKPVLELLF-------ADPAL-VTRQMVEdllkykrlDGVDDALRALAD--ALFAGgrqrVDLRDRLASLAIPV 317

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 757782862 222 LVIHGDDDQIVPLetcgkVAAEILPD-AQLKVYAGGSH 258
Cdd:PRK14875 318 LVIWGEQDRIIPA-----AHAQGLPDgVAVHVLPGAGH 350
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
28-278 1.38e-14

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 71.51  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  28 IVFSHGwpLTADAFEDQMF--FLGSKGYRVIAHDRRGHGRSAQPWEGHTMDQYADDLAELTAHL-NLQNAVHV-GHSTGG 103
Cdd:COG1647   18 VLLLHG--FTGSPAEMRPLaeALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILkAGYDKVIViGLSMGG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 104 GEVARYIGRHGtqRVAKAVLIGAvtPIMVKtdfNPNGVPKEVFDGIREGVVNDRAAFfyeltaafygynrpgakESKAVR 183
Cdd:COG1647   96 LLALLLAARYP--DVAGLVLLSP--ALKID---DPSAPLLPLLKYLARSLRGIGSDI-----------------EDPEVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 184 ESFVEQGLQGSIKALYDCIKafsetDLREDLRKMTIPTLVIHGDDDQIVPLEtcgkvAAEIL------PDAQLKVYAGGS 257
Cdd:COG1647  152 EYAYDRTPLRALAELQRLIR-----EVRRDLPKITAPTLIIQSRKDEVVPPE-----SARYIyerlgsPDKELVWLEDSG 221

                        250       260
                 ....*....|....*....|..
gi 757782862 258 HGICT-THKQQINQDLLNFIQS 278
Cdd:COG1647  222 HVITLdKDREEVAEEILDFLER 243
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 28-258 1.10e-12

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 65.57  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   28 IVFSHGWPLTADafedQMFFLGSKGYRVIAHDRRGHGRSAQPWEGHTMdqyADDLAELTAHLNLQNAVH-VGHSTGGGev 106
Cdd:pfam12697   1 VVLVHGAGLSAA----PLAALLAAGVAVLAPDLPGHGSSSPPPLDLAD---LADLAALLDELGAARPVVlVGHSLGGA-- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  107 arYIGRHGTQRVAKAVLigaVTPIMVKTDFNPNGVPkeVFDGIREGVVNDRAAFFYELTAAFYGYNRPGAKESKAVRESF 186
Cdd:pfam12697  72 --VALAAAAAALVVGVL---VAPLAAPPGLLAALLA--LLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALARLA 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757782862  187 veqglqgsikalydCIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLETCgkvAAEILPDAQLKVYAGGSH 258
Cdd:pfam12697 145 --------------ALLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQR---LLAALAGARLVVLPGAGH 199
PRK05855 PRK05855
SDR family oxidoreductase;
11-119 1.40e-10

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 61.15  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  11 DGSYLYFKDWGDRSGQPIVFSHGWPLTADAFEDQMFFLGSKgYRVIAHDRRGHGRSAQP--WEGHTMDQYADDLAELTAH 88
Cdd:PRK05855  11 DGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPkrTAAYTLARLADDFAAVIDA 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 757782862  89 LNLQNAVHV-GHSTGGGEVARYIGRHGT-QRVA 119
Cdd:PRK05855  90 VSPDRPVHLlAHDWGSIQGWEAVTRPRAaGRIA 122
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 12-212 6.71e-10

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 58.47  E-value: 6.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  12 GSYLYFKDWGdrSGQPIVFSHGWPLTADAFEDQMFFLGSKGyRVIAHDRRGHGRSAQPWEGHTMDQYADDLAELTAHLNL 91
Cdd:PRK03592  16 GSRMAYIETG--EGDPIVFLHGNPTSSYLWRNIIPHLAGLG-RCLAPDLIGMGASDKPDIDYTFADHARYLDAWFDALGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  92 QNAVHVGHSTGGGEVARYIGRHgTQRVAKAVLIGAVTPIMVKTDFNPNGvpKEVFDGIRegvvndraaffyeltaafygy 171
Cdd:PRK03592  93 DDVVLVGHDWGSALGFDWAARH-PDRVRGIAFMEAIVRPMTWDDFPPAV--RELFQALR--------------------- 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 757782862 172 nRPGAKESKAVRES-FVEQGLQGSIkalydcIKAFSETDLRE 212
Cdd:PRK03592 149 -SPGEGEEMVLEENvFIERVLPGSI------LRPLSDEEMAV 183
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 27-129 3.83e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 50.21  E-value: 3.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  27 PIVFSHGWPLTADAFEDQMFFLGSKGYRVIAHDrrghgrsaQPWEGHTMDQYADDLAE-LTAHLNLQNA--VH-VGHSTG 102
Cdd:COG1075    7 PVVLVHGLGGSAASWAPLAPRLRAAGYPVYALN--------YPSTNGSIEDSAEQLAAfVDAVLAATGAekVDlVGHSMG 78

                         90       100
                 ....*....|....*....|....*....
gi 757782862 103 GGeVAR-YIGRH-GTQRVAKAVLIGavTP 129
Cdd:COG1075   79 GL-VARyYLKRLgGAAKVARVVTLG--TP 104
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 3-258 8.29e-08

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 51.84  E-value: 8.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   3 QYDKITLK--DG----SYLYFKDWGDRSGQPIVFSHGWP-------LTADAFEDQmfflgskGYRVIAHDRRGHGRSaqp 69
Cdd:COG1073    9 NKEDVTFKsrDGiklaGDLYLPAGASKKYPAVVVAHGNGgvkeqraLYAQRLAEL-------GFNVLAFDYRGYGES--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  70 wEG---HTMDQYADDLAELTAHLNLQNAVH------VGHSTGGGEVARYIGRHgtQRVaKAVliGAVTPimvktdfnpng 140
Cdd:COG1073   79 -EGeprEEGSPERRDARAAVDYLRTLPGVDperiglLGISLGGGYALNAAATD--PRV-KAV--ILDSP----------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 141 vpkevfdgiregvVNDRAAFFYELTAAFYGYNRPGAKESKAVR-ESFVEQGLqgsikalydcikafsetDLREDLRKMTI 219
Cdd:COG1073  142 -------------FTSLEDLAAQRAKEARGAYLPGVPYLPNVRlASLLNDEF-----------------DPLAKIEKISR 191

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 757782862 220 PTLVIHGDDDQIVPLETCGKVAAEILPDAQLKVYAGGSH 258
Cdd:COG1073  192 PLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGH 230
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
208-259 2.60e-06

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 47.27  E-value: 2.60e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 757782862 208 TDLREDLRKMTIPTLVIHGDDDQIVPLETCGKVAAEI---LPDAQLKVYAGGSHG 259
Cdd:COG0412  146 DDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALaaaGVDVELHVYPGAGHG 200
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 21-158 3.21e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 47.98  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  21 GDRSGQPIVFSHGWPLTADAFEDQMFFLGSKgYRVIAHDRRGHGRSAQP-----WEGHTMDQYADDLAELTAHLNLQNAV 95
Cdd:PLN02894 101 SKEDAPTLVMVHGYGASQGFFFRNFDALASR-FRVIAIDQLGWGGSSRPdftckSTEETEAWFIDSFEEWRKAKNLSNFI 179

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782862  96 HVGHSTGGGEVARYIGRHgTQRVAKAVLIGavtpimvktdfnPNGVPKEVfDGIREGVVNDRA 158
Cdd:PLN02894 180 LLGHSFGGYVAAKYALKH-PEHVQHLILVG------------PAGFSSES-DDKSEWLTKFRA 228
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
212-258 6.84e-06

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 45.92  E-value: 6.84e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 757782862 212 EDLRKMTIPTLVIHGDDDQIVPLETCGKVAAEILPDAQLKVYAGGSH 258
Cdd:COG2945  136 SFLAPCPAPTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH 182
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 15-103 1.06e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 46.00  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  15 LYFKDWGDrsGQPIVFSHGWPLTADAFEDQMFFLGSKgYRVIAHDRRGHGRSAQPWE-GHTMDQYADDLAELTAHLNLQN 93
Cdd:PRK03204  26 IHYIDEGT--GPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPSGfGYQIDEHARVIGEFVDHLGLDR 102

                         90
                 ....*....|
gi 757782862  94 AVHVGHSTGG 103
Cdd:PRK03204 103 YLSMGQDWGG 112
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
20-278 1.96e-05

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 45.01  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  20 WGDRSGQP---IVFSHGWPLTADAFEDQMFFLGSKgYRVIAHDRRGHGRSAqpweGHTmdqyADDLAELTAHLNLQ---N 93
Cdd:PRK10349   5 WWQTKGQGnvhLVLLHGWGLNAEVWRCIDEELSSH-FTLHLVDLPGFGRSR----GFG----ALSLADMAEAVLQQapdK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  94 AVHVGHSTGGgEVARYIGRHGTQRVaKAVLIGAVTPIMVKTDFNPnGVPKEVFDGIREGVVNDraafFYELTAAFYGYNR 173
Cdd:PRK10349  76 AIWLGWSLGG-LVASQIALTHPERV-QALVTVASSPCFSARDEWP-GIKPDVLAGFQQQLSDD----FQRTVERFLALQT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 174 PGA----KESKAVRESFVEQGLQgSIKALYDCIKAFSETDLREDLRKMTIPTLVIHGDDDQIVPLETCgKVAAEILPDAQ 249
Cdd:PRK10349 149 MGTetarQDARALKKTVLALPMP-EVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVV-PMLDKLWPHSE 226

                        250       260
                 ....*....|....*....|....*....
gi 757782862 250 LKVYAGGSHGICTTHKQQINQDLLNFIQS 278
Cdd:PRK10349 227 SYIFAKAAHAPFISHPAEFCHLLVALKQR 255
PHA02857 PHA02857
monoglyceride lipase; Provisional
 10-269 3.64e-05

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 44.11  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  10 KDGSYLYFKDWGDRS-GQPIVF-SHGWPLTADAFEDQMFFLGSKGYRVIAHDRRGHGRSAQpwEGHTMDQYADDLAELTA 87
Cdd:PHA02857   8 LDNDYIYCKYWKPITyPKALVFiSHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNG--EKMMIDDFGVYVRDVVQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  88 HLNLQNAVHVGhstgggeVARYIGRHGtqrvakavlIGAVTPIMVKTDfNPNgvpkeVFDGI--REGVVNDRAAFFYELT 165
Cdd:PHA02857  86 HVVTIKSTYPG-------VPVFLLGHS---------MGATISILAAYK-NPN-----LFTAMilMSPLVNAEAVPRLNLL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862 166 AAF-YGYNRPGAKESKAVRESfVEQGLQGSIKALYD------------CIKAFSETD-LREDLRKMTIPTLVIHGDDDQI 231
Cdd:PHA02857 144 AAKlMGIFYPNKIVGKLCPES-VSRDMDEVYKYQYDplvnhekikagfASQVLKATNkVRKIIPKIKTPILILQGTNNEI 222

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 757782862 232 VPLETCGKVAAEILPDAQLKVYAGGSHGIcttHKQQIN 269
Cdd:PHA02857 223 SDVSGAYYFMQHANCNREIKIYEGAKHHL---HKETDE 257
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 192-277 9.47e-05

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 42.75  E-value: 9.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  192 QGSIKALYDCIK---------AFS-----ETDLREDLRKMT--IPTLVIHGDDDQIVPLETcGKVAAEIL----PDAQLK 251
Cdd:pfam02230 114 QGAMLALYSALTlplplggivAFSgflplPTKFPSHPNLVTkkTPIFLIHGEEDPVVPLAL-GKLAKEYLktslNKVELK 192

                          90       100
                  ....*....|....*....|....*.
gi 757782862  252 VYAGGSHGICtthkQQINQDLLNFIQ 277
Cdd:pfam02230 193 IYEGLAHSIC----GREMQDIKKFLS 214
YpfH COG0400
Predicted esterase [General function prediction only];
209-278 1.21e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 42.20  E-value: 1.21e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757782862 209 DLREDLRKMtiPTLVIHGDDDQIVPLEtCGKVAAEILP----DAQLKVYAGGsHGICtthkQQINQDLLNFIQS 278
Cdd:COG0400  132 APEAALAGT--PVFLAHGTQDPVIPVE-RAREAAEALEaagaDVTYREYPGG-HEIS----PEELADARAWLAE 197
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 3-103 2.41e-04

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 41.88  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862   3 QYDKITLKDGSYL--YFKDWGDRSGQPIVFSHGWPLTADAFEDQMFFLGSKGYRVIAHDRRGHGRSAQPW--EGHTMDQY 78
Cdd:PRK00870  22 HYVDVDDGDGGPLrmHYVDEGPADGPPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGRSDKPTrrEDYTYARH 101

                         90       100
                 ....*....|....*....|....*
gi 757782862  79 ADDLAELTAHLNLQNAVHVGHSTGG 103
Cdd:PRK00870 102 VEWMRSWFEQLDLTDVTLVCQDWGG 126
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 21-85 5.41e-04

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 41.02  E-value: 5.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757782862  21 GDRSGQPIVFSHGWPLTADAFEDQMFFLgSKGYRVIAHDRRGHGRSAQPWEG----HTMDQYADDLAEL 85
Cdd:PLN03084 123 GSNNNPPVLLIHGFPSQAYSYRKVLPVL-SKNYHAIAFDWLGFGFSDKPQPGygfnYTLDEYVSSLESL 190
PRK10673 PRK10673
esterase;
27-124 2.06e-03

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 38.94  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782862  27 PIVFSHGwpLTADAfeDQMFFLG---SKGYRVIAHDRRGHGRSaqPWEgHTMD--QYADDLAELTAHLNLQNAVHVGHST 101
Cdd:PRK10673  18 PIVLVHG--LFGSL--DNLGVLArdlVNDHDIIQVDMRNHGLS--PRD-PVMNypAMAQDLLDTLDALQIEKATFIGHSM 90

                         90       100
                 ....*....|....*....|...
gi 757782862 102 gGGEVARYIGRHGTQRVAKAVLI 124
Cdd:PRK10673  91 -GGKAVMALTALAPDRIDKLVAI 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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