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Conserved domains on  [gi|757782864|ref|WP_043001448|]
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MULTISPECIES: universal stress protein UspG [Citrobacter]

Protein Classification

adenine nucleotide alpha hydrolase family protein; NAD(+) synthase( domain architecture ID 10794167)

AANH (adenine nucleotide alpha hydrolase) family protein| NAD(+) synthase, utilizing glutamine or NH(3) as nitrogen source, converts deamido-NAD+ to NAD+

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15456 PRK15456
universal stress protein UspG; Provisional
 1-142 1.86e-91

universal stress protein UspG; Provisional


:

Pssm-ID: 185353  Cd Length: 142  Bit Score: 261.41  E-value: 1.86e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   1 MYKTIIMPVDVFEMELSDKAIRHAEFLAQQDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAETRLQTMVGHFSID 80
Cdd:PRK15456   1 MYKTIIMPVDVFEMELSDKAVRHAEFLAQDDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAEERLQTMVSHFTID 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757782864  81 PSRIKQHVRFGSVRDVVNELGEELNADVVVIGSRNPSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:PRK15456  81 PSRIKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTHLLGSNASSVIRHANLPVLVVR 142
 
Name Accession Description Interval E-value
PRK15456 PRK15456
universal stress protein UspG; Provisional
 1-142 1.86e-91

universal stress protein UspG; Provisional


Pssm-ID: 185353  Cd Length: 142  Bit Score: 261.41  E-value: 1.86e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   1 MYKTIIMPVDVFEMELSDKAIRHAEFLAQQDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAETRLQTMVGHFSID 80
Cdd:PRK15456   1 MYKTIIMPVDVFEMELSDKAVRHAEFLAQDDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAEERLQTMVSHFTID 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757782864  81 PSRIKQHVRFGSVRDVVNELGEELNADVVVIGSRNPSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:PRK15456  81 PSRIKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTHLLGSNASSVIRHANLPVLVVR 142
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-141 1.16e-25

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 94.22  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   1 MYKTIIMPVDvfEMELSDKAIRHAEFLAQQDGV-IHLLHVLPGSASlslhrFAADVRRFEEHLQHEAETRLQTMVGHFSI 79
Cdd:COG0589    1 MYKRILVPTD--GSEEAERALEYAAELAKALGAeLHLLHVVDPPPS-----AAAGPEELEEELREEAEEALEEAAERLEE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782864  80 DPSRIKQHVRFGSVRDVVNELGEELNADVVVIGSR-NPSITTHLLGSNASSVVRHATLPVLVV 141
Cdd:COG0589   74 AGVEVETVVREGDPAEAILEAAEELDADLIVMGSRgRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-142 2.06e-20

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 80.91  E-value: 2.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864    5 IIMPVDvfEMELSDKAIRHAEFLAQ-QDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAETRLQTMVGHFSIDPSr 83
Cdd:pfam00582   1 ILVAVD--GSEESKRALEWAAELAKaRGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVK- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   84 IKQHVRFGSVRDVVNELGEELNADVVVIGSR-NPSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRgRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 15-141 5.28e-20

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 79.70  E-value: 5.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864  15 ELSDKAIRHAEFLAQQDGV-IHLLHVLPGSASLSLHRFAADVRrfeEHLQHEAETRLQTMVGHFSIDPSRIKQHVRFGSV 93
Cdd:cd00293   10 EESERALEWALELAKRPGAeLTLLHVVDPPPSSSLSGGLEELA---DELKEEAEELLEEAKKLAEEAGVEVETIVVEGDP 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 757782864  94 RDVVNELGEELNADVVVIGSRNPSITTH-LLGSNASSVVRHATLPVLVV 141
Cdd:cd00293   87 AEAILEEAKELGADLIVMGSRGRSGLKRlLLGSVSEYVLRHAPCPVLVV 135
 
Name Accession Description Interval E-value
PRK15456 PRK15456
universal stress protein UspG; Provisional
 1-142 1.86e-91

universal stress protein UspG; Provisional


Pssm-ID: 185353  Cd Length: 142  Bit Score: 261.41  E-value: 1.86e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   1 MYKTIIMPVDVFEMELSDKAIRHAEFLAQQDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAETRLQTMVGHFSID 80
Cdd:PRK15456   1 MYKTIIMPVDVFEMELSDKAVRHAEFLAQDDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAEERLQTMVSHFTID 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757782864  81 PSRIKQHVRFGSVRDVVNELGEELNADVVVIGSRNPSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:PRK15456  81 PSRIKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTHLLGSNASSVIRHANLPVLVVR 142
PRK15005 PRK15005
universal stress protein UspF;
1-142 8.41e-34

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 115.29  E-value: 8.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   1 MYKTIIMPVDVFEMELSDKAIRHAEFLAQ-QDGVIHLLHVLPG---SASLSLhRFAADVRRFEEhLQHEAETRLQTMVGH 76
Cdd:PRK15005   1 MNRTILVPIDISDSELTQRVISHVEAEAKiDDAEVHFLTVIPSlpyYASLGL-AYSAELPAMDD-LKAEAKSQLEEIIKK 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757782864  77 FSIDPSRIKQHVRFGSVRDVVNELGEELNADVVVIGSRNPSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:PRK15005  79 FKLPTDRVHVHVEEGSPKDRILELAKKIPADMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR 144
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-141 1.16e-25

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 94.22  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   1 MYKTIIMPVDvfEMELSDKAIRHAEFLAQQDGV-IHLLHVLPGSASlslhrFAADVRRFEEHLQHEAETRLQTMVGHFSI 79
Cdd:COG0589    1 MYKRILVPTD--GSEEAERALEYAAELAKALGAeLHLLHVVDPPPS-----AAAGPEELEEELREEAEEALEEAAERLEE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782864  80 DPSRIKQHVRFGSVRDVVNELGEELNADVVVIGSR-NPSITTHLLGSNASSVVRHATLPVLVV 141
Cdd:COG0589   74 AGVEVETVVREGDPAEAILEAAEELDADLIVMGSRgRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-142 2.06e-20

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 80.91  E-value: 2.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864    5 IIMPVDvfEMELSDKAIRHAEFLAQ-QDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAETRLQTMVGHFSIDPSr 83
Cdd:pfam00582   1 ILVAVD--GSEESKRALEWAAELAKaRGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVK- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   84 IKQHVRFGSVRDVVNELGEELNADVVVIGSR-NPSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRgRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 15-141 5.28e-20

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 79.70  E-value: 5.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864  15 ELSDKAIRHAEFLAQQDGV-IHLLHVLPGSASLSLHRFAADVRrfeEHLQHEAETRLQTMVGHFSIDPSRIKQHVRFGSV 93
Cdd:cd00293   10 EESERALEWALELAKRPGAeLTLLHVVDPPPSSSLSGGLEELA---DELKEEAEELLEEAKKLAEEAGVEVETIVVEGDP 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 757782864  94 RDVVNELGEELNADVVVIGSRNPSITTH-LLGSNASSVVRHATLPVLVV 141
Cdd:cd00293   87 AEAILEEAKELGADLIVMGSRGRSGLKRlLLGSVSEYVLRHAPCPVLVV 135
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 3-142 4.50e-13

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 61.87  E-value: 4.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   3 KTIIMPVDvfEMELSDKAIRHA-EFLAQQDGVIHLLHVLP---------GSASLSLHRFAADVRRFEEHLQHEAETRLQT 72
Cdd:cd23659    1 RKVLIAVD--GSEESEYALEWAlENLHRPGDEVVLLHVIEppslpaaslGSGSEEWEALEEEAREKAEKLLEKYEKKLKE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757782864  73 MVGHfsidpsRIKQHVRFGSVRDVVNELGEELNADVVVIGSRN-PSITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:cd23659   79 EKGI------KVKVEVVAGDPGEVICKAAEELKADLIVMGSRGlGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 15-140 1.56e-06

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 44.57  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864  15 ELSDKAIRHAEFLAQQDGV-IHLLHVLPGSASLSLHRFA-ADVRRFEEHLQHEAETRLQTMVGHFSIDPSRIkqHVRFGS 92
Cdd:cd23660   19 DLNLRLIELAYSLAAQLKAeLHLVSAWPVTPENIAIELPeFDPTEYVDAIRGRHLEAMKALRQKFGIDEEQT--HVLEGL 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 757782864  93 VRDVVNELGEELNADVVVIGS--RNpSITTHLLGSNASSVVRHATLPVLV 140
Cdd:cd23660   97 PEEVIPDFAEELDADIVVLGTvaRT-GLSGALIGNTAEHVLDHLNCDLLA 145
PRK11175 PRK11175
universal stress protein UspE; Provisional
 14-113 1.38e-05

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 43.33  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864  14 MELSDKAIRHAEFLAQQ--DGVIHLLHVLPG---SASLSLHRFAADVrrFEEHLQHEAETRLQTMVGHFSIDPSriKQHV 88
Cdd:PRK11175 169 DALNEKLVEEAIDLAEQlnHAEVHLVNAYPVtpiNIAIELPEFDPSV--YNDAIRGQHLLAMKALRQKFGIDEE--QTHV 244

                         90       100
                 ....*....|....*....|....*
gi 757782864  89 RFGSVRDVVNELGEELNADVVVIGS 113
Cdd:PRK11175 245 EEGLPEEVIPDLAEHLDAELVILGT 269
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 2-142 3.08e-05

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 41.14  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864   2 YKTIIMPVDVFE--MELSDKAirhAEFLAQQDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQ---HEAETRLQTMVGh 76
Cdd:cd23657    1 YKHILVAVDLSPesQSLVDKA---VEIARENDAKLSLIHVDEDISEYYTGLIDVDIAALQDLEStmlEEALKNLSELAG- 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757782864  77 fsIDPSriKQHVRFGSVRDVVNELGEELNADVVVIGSRNPSITThLLGSNASSVVRHATLPVLVVR 142
Cdd:cd23657   77 --YPVD--HTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS-LLGSSARAVLNSAPCDVLIVP 137
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 17-142 1.79e-04

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 38.92  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782864  17 SDKAIRHAEFLAQQDGV-IHLLHVLPG--SASLSLHRFAADVRRFEEHLQH---EAETRLQTMVGhfSIDPSRIKQHVRF 90
Cdd:cd23944   12 SDAAVRWAAREAQLRQIpLTLVHVVPPvvVSWPEGPRPAEVLDWQQDEARQvieQARKVAEEASG--EGPPVKVETEIVP 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 757782864  91 GSVRDVVNELGEElnADVVVIGSRNP-SITTHLLGSNASSVVRHATLPVLVVR 142
Cdd:cd23944   90 GSPVPTLVEASRD--ATMVVVGSRGIgALAGLLLGSVSTSLVRHAHCPVAVIH 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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