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Conserved domains on  [gi|757799450|ref|WP_043016652|]
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MULTISPECIES: hemerythrin domain-containing protein [Citrobacter]

Protein Classification

hemerythrin domain-containing protein( domain architecture ID 10485355)

hemerythrin domain-containing protein adopts a four alpha helix bundle fold and may bind cations

Gene Ontology:  GO:0043169

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hemerythrin pfam01814
Hemerythrin HHE cation binding domain; Iteration of the HHE family found it to be related to ...
 3-133 7.84e-08

Hemerythrin HHE cation binding domain; Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organizm from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus P72360 has been noted to be important when the organizm switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger. This domain can bind oxygen (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043)


:

Pssm-ID: 396400 [Multi-domain]  Cd Length: 128  Bit Score: 47.60  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757799450    3 IDKMKNQHVEILEKISFLRKLSHAGVSSNAQEIATAIVSMSAIIKTHLSAEDQFLYPHIE--HDGSSTLRQVSSKFQREM 80
Cdd:pfam01814   3 IELLDAEHRRLRELLALLRALADALGDSHLRKLAELLDELVDELEAHHAAEEELLFPALErrSPGGEAPIEVLRKEHDEI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 757799450   81 TDIVSEYEVFSRRWNiasklvgNDAAFRCDANNVLRKVYERMQKENKDFYPLV 133
Cdd:pfam01814  83 RELLEELEALLKGAE-------PGAAFAELLEALAEWLREHIAKEEEVLFPLL 128
 
Name Accession Description Interval E-value
Hemerythrin pfam01814
Hemerythrin HHE cation binding domain; Iteration of the HHE family found it to be related to ...
 3-133 7.84e-08

Hemerythrin HHE cation binding domain; Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organizm from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus P72360 has been noted to be important when the organizm switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger. This domain can bind oxygen (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043)


Pssm-ID: 396400 [Multi-domain]  Cd Length: 128  Bit Score: 47.60  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757799450    3 IDKMKNQHVEILEKISFLRKLSHAGVSSNAQEIATAIVSMSAIIKTHLSAEDQFLYPHIE--HDGSSTLRQVSSKFQREM 80
Cdd:pfam01814   3 IELLDAEHRRLRELLALLRALADALGDSHLRKLAELLDELVDELEAHHAAEEELLFPALErrSPGGEAPIEVLRKEHDEI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 757799450   81 TDIVSEYEVFSRRWNiasklvgNDAAFRCDANNVLRKVYERMQKENKDFYPLV 133
Cdd:pfam01814  83 RELLEELEALLKGAE-------PGAAFAELLEALAEWLREHIAKEEEVLFPLL 128
 
Name Accession Description Interval E-value
Hemerythrin pfam01814
Hemerythrin HHE cation binding domain; Iteration of the HHE family found it to be related to ...
 3-133 7.84e-08

Hemerythrin HHE cation binding domain; Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organizm from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus P72360 has been noted to be important when the organizm switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger. This domain can bind oxygen (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043)


Pssm-ID: 396400 [Multi-domain]  Cd Length: 128  Bit Score: 47.60  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757799450    3 IDKMKNQHVEILEKISFLRKLSHAGVSSNAQEIATAIVSMSAIIKTHLSAEDQFLYPHIE--HDGSSTLRQVSSKFQREM 80
Cdd:pfam01814   3 IELLDAEHRRLRELLALLRALADALGDSHLRKLAELLDELVDELEAHHAAEEELLFPALErrSPGGEAPIEVLRKEHDEI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 757799450   81 TDIVSEYEVFSRRWNiasklvgNDAAFRCDANNVLRKVYERMQKENKDFYPLV 133
Cdd:pfam01814  83 RELLEELEALLKGAE-------PGAAFAELLEALAEWLREHIAKEEEVLFPLL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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