|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
11-345 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 563.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 11 MDYFFAQVEMRDNPKLKGKPVIVGGKAISRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMS 90
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 91 IFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYQN 170
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 171 VHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERT 250
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 251 FATDVNDDEEILRKVWELSGKTAERLNKLQ--KSAKTVTVKIKTYQFETLSKQMSlRDSVSSEEDIYNIAYLLYNDLKdp 328
Cdd:PRK02406 241 FAEDLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTKEHT-ADPLDKADLIELLAQALLRRLG-- 317
|
330
....*....|....*..
gi 758886311 329 DVPIRLIGVTVGNLEQS 345
Cdd:PRK02406 318 GRGVRLLGVGVTLLEPQ 334
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
7-342 |
2.23e-176 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 492.81 E-value: 2.23e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 7 IHIDMDYFFAQVEMRDNPKLKGKPVIVGGKAiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSA 86
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS-DRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 87 QIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVI 166
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 167 DYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVG 246
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 247 TERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLK 326
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELL 319
|
330
....*....|....*.
gi 758886311 327 DPDvPIRLIGVTVGNL 342
Cdd:cd03586 320 DGR-PIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
4-339 |
5.31e-158 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 446.13 E-value: 5.31e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 4 RRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKAiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRE 83
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 84 TSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGM 163
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 164 TVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRK 243
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 244 SVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYN 323
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLE 319
|
330
....*....|....*.
gi 758886311 324 DLKDPDVPIRLIGVTV 339
Cdd:COG0389 320 RIYRPGRPVRLLGVRL 335
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
2-353 |
1.24e-130 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 377.13 E-value: 1.24e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 2 TERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKAiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAY 81
Cdd:PRK14133 1 MDRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGIS-ERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 82 RETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLpasKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPD 161
Cdd:PRK14133 80 KEVSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEEPI---KIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 162 GMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRV 241
Cdd:PRK14133 157 GIKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 242 RKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAY-- 319
Cdd:PRK14133 237 RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACei 316
|
330 340 350
....*....|....*....|....*....|....
gi 758886311 320 LLYNDLKDpdvPIRLIGVTVGNLEQSTYKNMTIY 353
Cdd:PRK14133 317 LEHINIKE---PIRLIGLSVSNLSENKIEQLSFL 347
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
1-346 |
3.79e-101 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 305.71 E-value: 3.79e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 1 MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKAiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNG-YFVTSNFG 79
Cdd:PRK03348 2 RAQRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLG-GRGVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 80 AYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVrpDLPASKIAQY---IRKDILEQTHLTASAGVSYNKFLAKLASG 156
Cdd:PRK03348 81 VYRAASRRVFDTLRELSPVVEQLSFDEAFVEPAELA--GASAEEVEAFaerLRARVREETGLPASVGAGSGKQIAKIASG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 157 MNKPDGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKR-GRGLYNKARGIDHSE 235
Cdd:PRK03348 159 LAKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGATvGPALHRLARGIDDRP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 236 VKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIY 315
Cdd:PRK03348 239 VAERAEAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVLA 318
|
330 340 350
....*....|....*....|....*....|...
gi 758886311 316 NIAYLLyndLKDPDV--PIRLIGVTVGNLEQST 346
Cdd:PRK03348 319 ATARRL---LLDPDEigPIRLVGVGFSGLSDVR 348
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-342 |
9.52e-95 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 288.37 E-value: 9.52e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 6 IIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKaiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETS 85
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGG--KRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 86 AQIMSIFRSYTDKVEPMSLDEAYLDI--TELVRPDLPASKIAQYIRkDILEQTHLTASAGVSYNKFLAKLASGMNKPDGM 163
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLsgTERLHGAPPAVVLARFAR-RVEREIGITVSVGLSYNKFLAKIASDLDKPRGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 164 TVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRK 243
Cdd:PRK02794 195 SVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAK 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 244 SVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYn 323
Cdd:PRK02794 275 SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELL- 353
|
330 340
....*....|....*....|
gi 758886311 324 dLKDPD-VPIRLIGVTVGNL 342
Cdd:PRK02794 354 -EKETDgTAFRLIGIGVSDL 372
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
1-355 |
1.41e-94 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 287.70 E-value: 1.41e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 1 MTERRII-HIDMDYFFAQVEMRDNPKLKGKPVIVGGKAISR-GVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNF 78
Cdd:PRK01810 1 PKKGRVIfHVDMNSFFASVEIAYDPSLQGKPLAVAGNEKERkGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 79 GAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDIT---ELVRPdlpaSKIAQYIRKDILEQTHLTASAGVSYNKFLAKLAS 155
Cdd:PRK01810 81 DRYREASRQMFQILSEFTPLVQPVSIDEGYLDITdcyALGSP----LEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 156 GMNKPDGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSE 235
Cdd:PRK01810 157 DMKKPLGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 236 VKSSRV--RKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEED 313
Cdd:PRK01810 237 VDPEAIyqFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWEKRD 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 758886311 314 IYNIAYLLYNDLKDPDvPIRLIGVTVGNLE--QSTYKNMTIYDF 355
Cdd:PRK01810 317 IFQAASRLFKQHWNGD-PVRLLGVTATDLEwkTEAVKQLDLFSF 359
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
8-338 |
1.39e-77 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 241.88 E-value: 1.39e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 8 HIDMDYFFAQVEMRDNPKLKGKPVIVGGKAISRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQ 87
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 88 IMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQT-HLTASAGVSYNKFLAKLASGMNKPDGMTVI 166
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLTIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 167 DYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRL-FGKRGRGLYNKARGIDHSEVKSSRVRKSV 245
Cdd:cd00424 162 DPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALwGGVSGERLWYALRGIDDEPLSPPRPRKSF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 246 GTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQfetlSKQMSLRDSVS---------SEEDIYN 316
Cdd:cd00424 242 SHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVD----GRWSGHADIPSrsaprpistEDGELLH 317
|
330 340
....*....|....*....|....
gi 758886311 317 IAYLLYNDL--KDPDVPIRLIGVT 338
Cdd:cd00424 318 ALDKLWRALldDKGPRRLRRLGVR 341
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
1-345 |
4.80e-75 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 237.19 E-value: 4.80e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 1 MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGkaisrGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGA 80
Cdd:PRK03858 1 RADASILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 81 YRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKP 160
Cdd:PRK03858 76 YSRASKAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 161 DGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGK-RGRGLYNKARGIDHSEVKSS 239
Cdd:PRK03858 156 DGLLVVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPaAGRHLHALAHNRDPRRVETG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 240 RVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAY 319
Cdd:PRK03858 236 RRRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAAR 315
|
330 340
....*....|....*....|....*....
gi 758886311 320 LLYNDLKdPDVPIR---LIGVTVGNLEQS 345
Cdd:PRK03858 316 DLVAAAA-PLIAERgltLVGFAVSNLDDD 343
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
3-354 |
5.09e-75 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 237.21 E-value: 5.09e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 3 ERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKAISR-GVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAY 81
Cdd:PRK03103 2 ERVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRsGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 82 RETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGM---N 158
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNfakK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 159 KPDGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKS 238
Cdd:PRK03103 162 NPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSPVTP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 239 SRV--RKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFET---LSKQMSLRDSVSSEED 313
Cdd:PRK03103 242 HSLdrQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWptgFSRQMTLPEPTNLAME 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 758886311 314 IYNIAYLLYNDLKDpDVPIRLIGVTVGNLEQSTYKNMTIYD 354
Cdd:PRK03103 322 VYEAACKLFHRHWD-GKPVRRVGVTLSNLVSDDVWQLSLFG 361
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
3-342 |
1.42e-72 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 231.05 E-value: 1.42e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 3 ERRIIHIDMDYFFAQVEMRDNPKLKGKPVIV--GGKAISRgvVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGA 80
Cdd:cd01701 46 QRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchGKGPNSE--IASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 81 YRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPD-LPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNK 159
Cdd:cd01701 124 YEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETyELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAK 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 160 PDGMTVIDYQNVHDILMTLDIGDFPGVGK--ASKKVMHDNGIFNGRDLYEKTEFELIRLFG-KRGRGLYNKARGIDHSEV 236
Cdd:cd01701 204 PDGQYHLSAEKVEEFLSQLKVGDLPGVGSslAEKLVKLFGDTCGGLELRSKTKEKLQKVLGpKTGEKLYDYCRGIDDRPV 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 237 KSSRVRKSVGTERTFA---TDVNDDEEILRKvweLSGKTAERLNKLQKSAKTVTVKIK---------TYQF------ETL 298
Cdd:cd01701 284 TGEKERKSVSAEINYGirfTNVDDVEQFLQR---LSEELSKRLEESNVTGRQITLKLMkrapgapiePPKYmghgicDSF 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 758886311 299 SKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNL 342
Cdd:cd01701 361 SKSSTLGVATDDSGVIGTEAKKLFRDLSIPPEELRGVGIQVTKL 404
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
1-337 |
1.89e-71 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 226.06 E-value: 1.89e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 1 MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGK---AISRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSN 77
Cdd:PRK03352 2 AMPRWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNgdpTEPRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 78 FGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLditeLVRPDLPASkIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGM 157
Cdd:PRK03352 82 PAAYDAASEEVMATLRDLGVPVEVWGWDEAFL----GVDTDDPEA-LAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 158 NKPDGMTVIDYQNVHDILmtldiGDFP-----GVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFG-KRGRGLYNKARGI 231
Cdd:PRK03352 157 AKPAGVFRLTDANWMAVM-----GDRPtdalwGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 232 DHSEVKSS-RVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSS 310
Cdd:PRK03352 232 GDTEVSAEpWVPRSRSREVTFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTKIRKLPEPTTD 311
|
330 340
....*....|....*....|....*..
gi 758886311 311 EEDIYNIAYLLYnDLKDPDVPIRLIGV 337
Cdd:PRK03352 312 PDVIEAAALDVL-DRFELDRPVRLLGV 337
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
9-155 |
8.36e-71 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 217.44 E-value: 8.36e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 9 IDMDYFFAQVEMRDNPKLKGKPVIVGGKAiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQI 88
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGN-GRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 758886311 89 MSIFRSY-TDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLAS 155
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLAS 147
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
6-355 |
5.26e-67 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 215.04 E-value: 5.26e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 6 IIHIDMDYFFAQVEMRDNPKLKGKPVIV---GGKAISRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYR 82
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 83 ETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDG 162
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 163 MTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGK-RGRGLYNKARGIDHSEVKsSRV 241
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEaKAKYLFSLARNEYNEPVR-ARV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 242 RKSVGTERTFATDVNDDEEILRKvweLSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVsSEEDIYNIAYLL 321
Cdd:PRK01216 242 RKSIGRYVTLPRNTRDLEEIKPY---LKRAIEEAYYKLDGIPKAIHVVAIMEDLDIVSRGRTFTHGI-SKETAYREAVRL 317
|
330 340 350
....*....|....*....|....*....|....*
gi 758886311 322 YNDLKDPDV-PIRLIGVTVGNLeqstYKNMTIYDF 355
Cdd:PRK01216 318 LQKILEEDErKIRRIGVRFSKI----IEAIGLDKF 348
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
8-341 |
1.83e-58 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 192.91 E-value: 1.83e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 8 HIDMDYFFAQVEMRDNPKLKGKPVIVggkaISRGVVSTASYEARKYGVHSAMPMSQAHKLCPN-------GYFVTSNFGA 80
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV----VQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDlilahvaTYKKGEDEAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 81 ----------------YRETSAQIMSIFRSYTDKVEPMSLDEAYLDItelvrpdlpASKIAQYIRKDILEQTHLTASAGV 144
Cdd:cd01702 78 yhenpsparhkvsldpYRRASRKILNILKRFGDVVEKASIDEAYLDL---------GSRIVEEIRQQVYDELGYTCSAGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 145 SYNKFLAKLASGMNKPDGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHD--NGIFNGRDL-YEKTEFELIRLFG-KR 220
Cdd:cd01702 149 AHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGLGGKLGEEIIDllGLPTEGDVAgFRSSESDLQEHFGeKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 221 GRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKvW--ELSGKTAERLNKL----QKSAKTVTVKIKTYQ 294
Cdd:cd01702 229 GEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFPGKTALSTEDVQH-WllVLASELNSRLEDDryenNRRPKTLVLSLRQRG 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 758886311 295 FE-TLSKQMSLRDSVSseEDIYNIAYLLYNDL-KDPDV-----PIRLIGVTVGN 341
Cdd:cd01702 308 DGvRRSRSCALPRYDA--QKIVKDAFKLIKAInEEGLGlawnyPLTLLSLSFTK 359
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
7-341 |
5.70e-51 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 174.20 E-value: 5.70e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 7 IHIDMDYFFAQVEMRDNPKLKGKPVIVGGKAIsrgvVSTASYEARKYGVHSAMPMSQAHKLCP-----NGYFVTSnfgaY 81
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYI----VVTCNYEARRLGVKKLMSIKDAKEICPdlvlvNGEDLTP----F 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 82 RETSAQIMSIFRSYT--DKVEPMSLDEAYLDITELVRpdLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNK 159
Cdd:cd01703 73 RDMSKKVYRLLRSYSwnDRVERLGFDENFMDVTEMRL--LVASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 160 PDGMTVIDYQNVHDILMTLDIGDF---PGVGKASKKVMHDNGIFNGRDLYEKT--------------EFELIR-LFGKR- 220
Cdd:cd01703 151 PNQQTTLLPPSCADLMDFMDLHDLrkiPGIGYKTAAKLEAHGISSVRDLQEFSnrnrqtvgaapsllELLLMVkEFGEGi 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 221 GRGLYNKARGIDHSEVKSSR-VRKSVGTERTFA-TDVNDDEEILRKVWELSGKTAERLNKLQKSAKTV------TVKIKT 292
Cdd:cd01703 231 GQRIWKLLFGRDTSPVKPASdFPQQISIEDSYKkCSLEEIREARNKIEELLASLLERMKQDLQEVKAGdgrrphTLRLTL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 758886311 293 YQFETL-------SKQMSLRDSV--SSEEDIYNIAYL-------LYNDLKDPDVP----IRLIGVTVGN 341
Cdd:cd01703 311 RRYTSTkkhynreSKQAPIPSHVfqKLTGGNEIAARPiekilmrLFRELVPPKNVkgfnLTLLNVCFTN 379
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
9-341 |
1.44e-49 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 169.27 E-value: 1.44e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 9 IDMDYFFAQVEMRDNPKLKGKPVIVGGKAisRGVVSTASYEARKYGVHSAMPMSQAHKLCP--NGYFVTSNFGAYRETSA 86
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVLSNN--DGCVIARSPEAKALGIKMGSPYFKVPDLLErhGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 87 QIMSIFRSYTDKVEPMSLDEAYLDITELVRPDlPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGM----NKPDG 162
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRFG-DLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakkkNPYGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 163 MTVIDYQNVHD-ILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEV-KSSR 240
Cdd:cd01700 160 VVDLTDEEVRDkLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLeEYPP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 241 VRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQM--SLRDSVSSEE--DIYN 316
Cdd:cd01700 240 PKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYsaTNTLPYPTNDtrEIVK 319
|
330 340
....*....|....*....|....*
gi 758886311 317 IAYLLYNDLKDPDVPIRLIGVTVGN 341
Cdd:cd01700 320 AALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
4-302 |
1.27e-34 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 133.61 E-value: 1.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 4 RRI---IHIDMDYFFAQVEMRDNPKLKGKPVIVGgkaiSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGA 80
Cdd:PTZ00205 130 RRLgtyIHLDMDMFYAAVEIKKHPEYAAIPLAIG----TMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDA 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 81 YRETSAQIMSIFRSYTDKVEPMSLDEAYLDIT---ELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGM 157
Cdd:PTZ00205 206 YNEESNTVRRIVAEYDPNYISFGLDELTLEVSayiERFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNI 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 158 NKPDGMTVIDYQNVHDILMTL-DIG--DFPGVGKASKKVMHDNGIFNGRDLYEKtEFELIRLF-GKRGRGLYNKARGI-- 231
Cdd:PTZ00205 286 NKPNGQHDLNLHTRGDVMTYVrDLGlrSVPGVGKVTEALLKGLGITTLSDIYNR-RVELCYILhNNLFRFLLGASIGImq 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 232 ----------DHSEVKSSRVRKSVGTERTFATdVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIK--TYQFETLS 299
Cdd:PTZ00205 365 wpdaataantENCEGATGGQRKAISSERSFTT-PRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRwaSYRYQQYT 443
|
...
gi 758886311 300 KQM 302
Cdd:PTZ00205 444 KSL 446
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
242-343 |
1.92e-29 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 109.19 E-value: 1.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 242 RKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLL 321
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80
|
90 100
....*....|....*....|..
gi 758886311 322 YNDLKDPDvPIRLIGVTVGNLE 343
Cdd:pfam11799 81 LRRLYRGR-PVRLLGVSLSNLV 101
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
8-295 |
8.96e-18 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 84.05 E-value: 8.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 8 HIDMDYFFAQVEMRDNPKLKGKPVIVGGKaiSRGVVSTASYEARKYGVHSAMP-MSQAHKLCPNG-YFVTSNFGAYRETS 85
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSN--NDGCVIARSAEAKALGIKMGDPwFKQKDLFRRCGvVCFSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 86 AQIMSIFRSYTDKVEPMSLDEAYLDITElVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNK---PDG 162
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKkwqRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 163 MTVIDYQNVH---DILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEkTEFELIR-----LFGKRGRGLynkaRG---I 231
Cdd:PRK03609 161 GGVVDLSNLErqrKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLAD-TNIRFIRkhfnvVLERTVREL----RGepcL 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 758886311 232 DHSEvkSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQF 295
Cdd:PRK03609 236 SLEE--FAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPF 297
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
9-276 |
2.17e-10 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 61.24 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 9 IDMDYFFAQVEMRDNPKLKGKP-VIVGGKAisRGVVSTASYEARKYGVHSAMPMSQAHKLCPNG----YFVTSNFGAYRE 83
Cdd:cd03468 3 LWFPRLPLDALLRNRPADDEAPlAVVERKK--AGRILACNAAARAAGVRPGMPLAEALALCPNLqvveYDPEADARALQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 84 TSAqimSIFRsYTDKVEPMSLDEAYLDITELVR--PDLPASKIAQYIRkdiLEQTHLTASAGVSYNKFLAKLASGMNKPd 161
Cdd:cd03468 81 LAL---WLLR-FTPLVALDGPDGLLLDVTGCLHlfGGEDALAASLRAA---LATLGLSARAGIADTPGAAWLLARAGGG- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758886311 162 gmTVIDYQNVHDILMTLDIG---DFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKS 238
Cdd:cd03468 153 --RGVLRREALAAALVLLAPlpvAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLF 230
|
250 260 270
....*....|....*....|....*....|....*...
gi 758886311 239 SRVRKSVGtertFATDVNDDEEIlrkvWELSGKTAERL 276
Cdd:cd03468 231 SPPPPAFD----FRLELQLEEPI----ARGLLFPLRRL 260
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
168-199 |
1.30e-03 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 35.84 E-value: 1.30e-03
10 20 30
....*....|....*....|....*....|..
gi 758886311 168 YQNVHDILMTLDIGDFPGVGKASKKVMHDNGI 199
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
