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Conserved domains on  [gi|759537505|ref|WP_043257519|]
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VanZ family protein [Streptomyces sp. Tu6071]

Protein Classification

VanZ family protein( domain architecture ID 10008822)

VanZ family protein is an integral membrane protein similar to Enterococcus faecium protein VanZ, which confers low-level resistance to the glycopeptide antibiotic teicoplanin (Te)

Gene Ontology:  GO:0046677|GO:0071555|GO:0005576

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
33-124 5.31e-25

Glycopeptide antibiotics resistance protein [Defense mechanisms];


:

Pssm-ID: 443799  Cd Length: 91  Bit Score: 93.74  E-value: 5.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759537505  33 NLHPGHSLRQYAEEYTFLAAcKQVGGNLLLGAPFGVLLPLLVPRRMRLVRVFVVTLLVMSLVELAQGaVIEGRAFDVDDV 112
Cdd:COG4767    1 NLVPFKSILEDLALGGSIAV-IQILGNILLFVPLGFLLPLLFKRLRSFKRVLLLGFLLSLLIEVLQL-ILPGRVFDIDDL 78

                         90
                 ....*....|..
gi 759537505 113 ILNTAGALLGYA 124
Cdd:COG4767   79 ILNTLGALLGYL 90
 
Name Accession Description Interval E-value
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
33-124 5.31e-25

Glycopeptide antibiotics resistance protein [Defense mechanisms];


Pssm-ID: 443799  Cd Length: 91  Bit Score: 93.74  E-value: 5.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759537505  33 NLHPGHSLRQYAEEYTFLAAcKQVGGNLLLGAPFGVLLPLLVPRRMRLVRVFVVTLLVMSLVELAQGaVIEGRAFDVDDV 112
Cdd:COG4767    1 NLVPFKSILEDLALGGSIAV-IQILGNILLFVPLGFLLPLLFKRLRSFKRVLLLGFLLSLLIEVLQL-ILPGRVFDIDDL 78

                         90
                 ....*....|..
gi 759537505 113 ILNTAGALLGYA 124
Cdd:COG4767   79 ILNTLGALLGYL 90
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 58-126 1.01e-16

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 71.74  E-value: 1.01e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759537505   58 GNLLLGAPFGVLLPLLVPRRMRlvRVFVVTLLVMSLVELAQgAVIEGRAFDVDDVILNTAGALLGYAFL 126
Cdd:pfam04892  12 RNIAHFVPFGFLLPLLFKRRFL--KTLLLGFLYSLSDELHQ-LFVPGRSFDVDDVILNTLGALIGILLY 77
 
Name Accession Description Interval E-value
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
33-124 5.31e-25

Glycopeptide antibiotics resistance protein [Defense mechanisms];


Pssm-ID: 443799  Cd Length: 91  Bit Score: 93.74  E-value: 5.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759537505  33 NLHPGHSLRQYAEEYTFLAAcKQVGGNLLLGAPFGVLLPLLVPRRMRLVRVFVVTLLVMSLVELAQGaVIEGRAFDVDDV 112
Cdd:COG4767    1 NLVPFKSILEDLALGGSIAV-IQILGNILLFVPLGFLLPLLFKRLRSFKRVLLLGFLLSLLIEVLQL-ILPGRVFDIDDL 78

                         90
                 ....*....|..
gi 759537505 113 ILNTAGALLGYA 124
Cdd:COG4767   79 ILNTLGALLGYL 90
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 58-126 1.01e-16

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 71.74  E-value: 1.01e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759537505   58 GNLLLGAPFGVLLPLLVPRRMRlvRVFVVTLLVMSLVELAQgAVIEGRAFDVDDVILNTAGALLGYAFL 126
Cdd:pfam04892  12 RNIAHFVPFGFLLPLLFKRRFL--KTLLLGFLYSLSDELHQ-LFVPGRSFDVDDVILNTLGALIGILLY 77
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
2-125 3.31e-06

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 44.99  E-value: 3.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759537505   2 VVAFLLLVAFSAVLAKLTLTPSPASDGLAGSNLHP----GHSLrqyaeEYTFLAAckqvggnLLLGApfgvLLPLLVPRR 77
Cdd:COG5652    8 RLRWLLVLLWAGLIFYLSLQPGEESPSLSGLVFFGfdklAHFL-----AYFILGF-------LLALA----LRRSRLRRR 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 759537505  78 MRLVRVFVVTLLVMSLVELAQGAViEGRAFDVDDVILNTAGALLGYAF 125
Cdd:COG5652   72 RALLLAVLIAVLYAILDEIHQSFV-PGRSASLADVLADTLGALLGVLL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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