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Conserved domains on  [gi|759931048|ref|WP_043616345|]
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type I methionyl aminopeptidase [Chromobacterium violaceum]

Protein Classification

type I methionyl aminopeptidase( domain architecture ID 10000257)

type I methionyl aminopeptidase (M24A family metallopeptidase) catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides

CATH:  3.90.230.10
EC:  3.4.11.18
Gene Ontology:  GO:0070006|GO:0046914|GO:0006508|GO:0004239
MEROPS:  M24
PubMed:  7674922

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
4-255 3.27e-163

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 452.15  E-value: 3.27e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRD-HGAIPAFLGYYGFPKSICTSVNEVVVHGIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  84 SAKqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:COG0024   80 SDR-VLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:COG0024  159 SVVREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTE 238

                        250
                 ....*....|..
gi 759931048 244 DGFEVLTPWPDG 255
Cdd:COG0024  239 DGPEILTLPDGG 250
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
4-255 3.27e-163

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 452.15  E-value: 3.27e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRD-HGAIPAFLGYYGFPKSICTSVNEVVVHGIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  84 SAKqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:COG0024   80 SDR-VLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:COG0024  159 SVVREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTE 238

                        250
                 ....*....|..
gi 759931048 244 DGFEVLTPWPDG 255
Cdd:COG0024  239 DGPEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 4-255 1.12e-152

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 425.32  E-value: 1.12e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:PRK05716   3 ITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRD-QGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  84 SAKqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:PRK05716  82 SDK-VLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:PRK05716 161 SVVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTE 240

                        250
                 ....*....|..
gi 759931048 244 DGFEVLTPWPDG 255
Cdd:PRK05716 241 DGPEILTLRPEE 252
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 12-250 2.24e-137

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 386.08  E-value: 2.24e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  12 VAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIPSAKqILRD 91
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEE-HGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDR-VLKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  92 GDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCG 171
Cdd:cd01086   79 GDIVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGG 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759931048 172 HGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTDDGFEVLT 250
Cdd:cd01086  159 HGIGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 4-250 1.66e-115

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 331.23  E-value: 1.66e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048    4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQkAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHG-AKPAFLGYYGFPGSVCISVNEVVIHGIP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   84 SaKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:TIGR00500  80 D-KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:TIGR00500 159 SVVREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITD 238


                  ....*..
gi 759931048  244 DGFEVLT 250
Cdd:TIGR00500 239 NGPEILT 245
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 13-243 7.17e-60

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 188.60  E-value: 7.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   13 AKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAkpanvGYYGYPKTICSSVNQVVCHGIPSaKQILRDG 92
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA-----RGPAFPPIVASGPNAAIPHYIPN-DRVLKPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   93 DIVNIDV-AVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFS-VVREYC 170
Cdd:pfam00557  75 DLVLIDVgAEYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGL 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759931048  171 GHGIGKVYHEEPevlHYGRPGIGMKLKRGMVFTIEPMInagkagtrqlgdgwtvVTQDGSWSAQWEHMVAVTD 243
Cdd:pfam00557 155 GHGIGLEVHEGP---YISRGGDDRVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
4-255 3.27e-163

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 452.15  E-value: 3.27e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRD-HGAIPAFLGYYGFPKSICTSVNEVVVHGIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  84 SAKqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:COG0024   80 SDR-VLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:COG0024  159 SVVREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTE 238

                        250
                 ....*....|..
gi 759931048 244 DGFEVLTPWPDG 255
Cdd:COG0024  239 DGPEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 4-255 1.12e-152

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 425.32  E-value: 1.12e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:PRK05716   3 ITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRD-QGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  84 SAKqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:PRK05716  82 SDK-VLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:PRK05716 161 SVVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTE 240

                        250
                 ....*....|..
gi 759931048 244 DGFEVLTPWPDG 255
Cdd:PRK05716 241 DGPEILTLRPEE 252
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 12-250 2.24e-137

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 386.08  E-value: 2.24e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  12 VAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIPSAKqILRD 91
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEE-HGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDR-VLKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  92 GDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCG 171
Cdd:cd01086   79 GDIVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGG 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759931048 172 HGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTDDGFEVLT 250
Cdd:cd01086  159 HGIGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 4-250 1.66e-115

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 331.23  E-value: 1.66e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048    4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQkAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHG-AKPAFLGYYGFPGSVCISVNEVVIHGIP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   84 SaKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:TIGR00500  80 D-KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:TIGR00500 159 SVVREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITD 238


                  ....*..
gi 759931048  244 DGFEVLT 250
Cdd:TIGR00500 239 NGPEILT 245
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 1-250 4.66e-111

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 320.25  E-value: 4.66e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   1 MSRVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCH 80
Cdd:PRK12896   5 GRGMEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEE-HGAIPSPEGYYGFPGSTCISVNEEVAH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  81 GIPSAKqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITES 160
Cdd:PRK12896  84 GIPGPR-VIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 161 AGFSVVREYCGHGIGKVYHEEP-EVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMV 239
Cdd:PRK12896 163 NGYSVVRDLTGHGVGRSLHEEPsVILTYTDPLPNRLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTV 242

                        250
                 ....*....|.
gi 759931048 240 AVTDDGFEVLT 250
Cdd:PRK12896 243 VVTRDGPEILT 253
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 3-250 3.51e-79

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 243.98  E-value: 3.51e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   3 RVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGI 82
Cdd:PLN03158 134 SVEIKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIA-AGGYPSPLNYHFFPKSCCTSVNEVICHGI 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  83 PSAKQiLRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAG 162
Cdd:PLN03158 213 PDARK-LEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSG 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 163 FSVVREYCGHGIGKVYHEEPEVLHYGR-PGIGMkLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAV 241
Cdd:PLN03158 292 LSVVKSYCGHGIGELFHCAPNIPHYARnKAVGV-MKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLV 370


                 ....*....
gi 759931048 242 TDDGFEVLT 250
Cdd:PLN03158 371 TETGVEVLT 379
PRK12318 PRK12318
methionyl aminopeptidase;
3-252 5.79e-77

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 235.10  E-value: 5.79e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   3 RVVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDarcnEYIVKVQK-----AKPANVGYYGYPKTICSSVNQV 77
Cdd:PRK12318  40 DIIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELD----ELSRELHKeynaiPAPLNYGSPPFPKTICTSLNEV 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  78 VCHGIPSAKQiLRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAI 157
Cdd:PRK12318 116 ICHGIPNDIP-LKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENC 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 158 TESAGFSVVREYCGHGIGKVYHEEPEVLHYgRPGIGMKLKRGMVFTIEPMINAG-KAGTRQLGDGWTVVTQDGSWSAQWE 236
Cdd:PRK12318 195 ADKYGFSVVDQFVGHGVGIKFHENPYVPHH-RNSSKIPLAPGMIFTIEPMINVGkKEGVIDPINHWEARTCDNQPSAQWE 273

                        250
                 ....*....|....*.
gi 759931048 237 HMVAVTDDGFEVLTPW 252
Cdd:PRK12318 274 HTILITETGYEILTLL 289
PRK12897 PRK12897
type I methionyl aminopeptidase;
4-250 1.34e-67

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 209.51  E-value: 1.34e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvQKAKPANVGYYGYPKTICSSVNQVVCHGIP 83
Cdd:PRK12897   2 ITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEK-HGATSEQKGYNGYPYAICASVNDEMCHAFP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  84 sAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGF 163
Cdd:PRK12897  81 -ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 164 SVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMINAGKAGTRQLGDGWTVVTQDGSWSAQWEHMVAVTD 243
Cdd:PRK12897 160 SVARDFTGHGIGKEIHEEPAIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITK 239


                 ....*..
gi 759931048 244 DGFEVLT 250
Cdd:PRK12897 240 DGPIILT 246
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 13-243 7.17e-60

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 188.60  E-value: 7.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   13 AKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAkpanvGYYGYPKTICSSVNQVVCHGIPSaKQILRDG 92
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA-----RGPAFPPIVASGPNAAIPHYIPN-DRVLKPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   93 DIVNIDV-AVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFS-VVREYC 170
Cdd:pfam00557  75 DLVLIDVgAEYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGL 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759931048  171 GHGIGKVYHEEPevlHYGRPGIGMKLKRGMVFTIEPMInagkagtrqlgdgwtvVTQDGSWSAQWEHMVAVTD 243
Cdd:pfam00557 155 GHGIGLEVHEGP---YISRGGDDRVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
6-256 1.20e-46

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 157.29  E-value: 1.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   6 IKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvqkakpANVGYYGYPkTICSS-VNQVVCHGIPS 84
Cdd:COG0006   73 IKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRR------RGAEGPSFD-TIVASgENAAIPHYTPT 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  85 AKQIlRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFs 164
Cdd:COG0006  146 DRPL-KPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGY- 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 165 vvREY----CGHGIGKVYHEEPEVlhygRPGIGMKLKRGMVFTIEPMI-NAGKAGTRqlgdgwtvvtqdgswsaqWEHMV 239
Cdd:COG0006  224 --GEYfphgTGHGVGLDVHEGPQI----SPGNDRPLEPGMVFTIEPGIyIPGIGGVR------------------IEDTV 279

                        250
                 ....*....|....*..
gi 759931048 240 AVTDDGFEVLTPWPDGL 256
Cdd:COG0006  280 LVTEDGAEVLTRLPREL 296
PRK07281 PRK07281
methionyl aminopeptidase;
4-250 1.30e-46

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 156.93  E-value: 1.30e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   4 VVIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDarcnEYIVKVQKAK---PANVGYYG----YPKTICSSVNQ 76
Cdd:PRK07281   2 ITLKSAREIEAMDRAGDFLASIHIGLRDLIKPGVDMWEVE----EYVRRRCKEEnvlPLQIGVDGammdYPYATCCGLND 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  77 VVCHGIPSaKQILRDGDIVNID---------------------VAVIK------NGWHGDSSRMFYVGRPSAEAKRLVET 129
Cdd:PRK07281  78 EVAHAFPR-HYILKEGDLLKVDmvlsepldksivdvsklnfdnVEQMKkytesyRGGLADSCWAYAVGTPSDEVKNLMDV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 130 CYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCGHGIGKVYHEEPEVLHYGRPGIGMKLKRGMVFTIEPMIN 209
Cdd:PRK07281 157 TKEAMYRGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLREGMVLTIEPMIN 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 759931048 210 AGKAGT-RQLGDGWTVVTQDGSWSAQWEHMVAVTDDGFEVLT 250
Cdd:PRK07281 237 TGTWEIdTDMKTGWAHKTLDGGLSCQYEHQFVITKDGPVILT 278
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 12-245 9.81e-39

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 134.12  E-value: 9.81e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  12 VAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVqkakpanvGYYGYPKTICSSVNQV-VCHGIPSAKqILR 90
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAA--------GGYPAGPTIVGSGARTaLPHYRPDDR-RLQ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  91 DGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVR-EY 169
Cdd:cd01066   72 EGDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFgHR 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759931048 170 CGHGIGKVYHEEPevlhYGRPGIGMKLKRGMVFTIEPMINAgkagtrqlgdgwtvvtqDGSWSAQWEHMVAVTDDG 245
Cdd:cd01066  152 TGHGIGLEIHEPP----VLKAGDDTVLEPGMVFAVEPGLYL-----------------PGGGGVRIEDTVLVTEDG 206
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 12-246 1.97e-32

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 118.00  E-value: 1.97e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  12 VAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPAnvgyygYPKTICSSVNQVVCHGIPSAKqILRD 91
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPS------FDTIVASGPNSALPHGVPSDR-KIEE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  92 GDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSvvrEY-- 169
Cdd:cd01092   74 GDLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYG---EYfi 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 170 --CGHGIGKVYHEEPEVlhygRPGIGMKLKRGMVFTIEPMIN-AGKAGTRqlgdgwtvvtqdgswsaqWEHMVAVTDDGF 246
Cdd:cd01092  151 hrTGHGVGLEVHEAPYI----SPGSDDVLEEGMVFTIEPGIYiPGKGGVR------------------IEDDVLVTEDGC 208
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 14-250 6.54e-22

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 91.93  E-value: 6.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  14 KAREAGKLVAELLAMIGEHVKPGVSTEELdARCNEYIVKVQKAKPAnvgyygYPKTIcsSVNQVVCHGIPSA--KQILRD 91
Cdd:cd01088    3 KYREAGEIHRQVRKYAQSLIKPGMTLLEI-AEFVENRIRELGAGPA------FPVNL--SINECAAHYTPNAgdDTVLKE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  92 GDIVNIDVAVIKNGWHGDSSrmFYVgRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCG 171
Cdd:cd01088   74 GDVVKLDFGAHVDGYIADSA--FTV-DFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 172 HGIGKvY--HEEPEVLHYGRPGiGMKLKRGMVFTIEP-------MINAGKAGT---------------RQL--------- 218
Cdd:cd01088  151 HSIER-YrlHAGKSIPNVKGGE-GTRLEEGDVYAIEPfattgkgYVHDGPECSiymlnrdkplrlpraRKLldviyenfg 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 759931048 219 -----------------------------GDGWTVVT-QDGSWSAQWEHMVAVTDDGFEVLT 250
Cdd:cd01088  229 tlpfarrwldrlgetkllmalknlckagiVYPYPVLKeISGGYVAQFEHTIIVREDGKEVTT 290
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 17-211 1.33e-19

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 85.99  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   17 EAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVqKAKPAnvgyygYPKTIcsSVNQVVCHGIPSA--KQILRDGDI 94
Cdd:TIGR00501  10 EAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIREL-GAEPA------FPCNI--SINECAAHFTPKAgdKTVFKDGDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   95 VNIDVAVIKNGWHGDSSRMFYVGrpsAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSVVREYCGHGI 174
Cdd:TIGR00501  81 VKLDLGAHVDGYIADTAITVDLG---DQYDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSM 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 759931048  175 gkvyheEPEVLHYGRP------GIGMKLKRGMVFTIEPMINAG 211
Cdd:TIGR00501 158 ------APYRLHGGKSipnvkeRDTTKLEEGDVVAIEPFATDG 194
PRK09795 PRK09795
aminopeptidase; Provisional
 6-253 3.63e-18

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 82.68  E-value: 3.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   6 IKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCnEYIVKVQKAKPAnvgyyGYPKTICSSVNQVVCHGIPSA 85
Cdd:PRK09795 127 IKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAEL-EWFMRQQGAEKA-----SFDTIVASGWRGALPHGKASD 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  86 KqILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKR-----LVETCYDATCAGIRAVRPGATLGDIGHAIQAITES 160
Cdd:PRK09795 201 K-IVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 161 AGFSvvrEY----CGHGIGKVYHEEPEVlhygRPGIGMKLKRGMVFTIEPMIN-AGKAGTRqlgdgwtvvtqdgswsaqW 235
Cdd:PRK09795 280 AGYG---DYfghnTGHAIGIEVHEDPRF----SPRDTTTLQPGMLLTVEPGIYlPGQGGVR------------------I 334

                        250
                 ....*....|....*...
gi 759931048 236 EHMVAVTDDGFEVLTPWP 253
Cdd:PRK09795 335 EDVVLVTPQGAEVLYAMP 352
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 16-250 3.69e-13

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 67.21  E-value: 3.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  16 REAGKLVAE--LLAMigEHVKPGVSTEELDARCnEYIVKVQKAKPAnvgyYGYPkTICSSvNQVVCHGIPsAKQILRDGD 93
Cdd:cd01087    5 RKACDISAEahRAAM--KASRPGMSEYELEAEF-EYEFRSRGARLA----YSYI-VAAGS-NAAILHYVH-NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  94 IVNIDVAVIKNGWHGDSSRMFYV-GRPSAEAKRLVETCYDATCAGIRAVRPGATLGDI-GHAIQAITE------------ 159
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhLLAHRVLAEglkelgilkgdv 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 160 --SAGFSVVREYCGHGIG-----KVyHEEPEVLHYGRPGIgmKLKRGMVFTIEPminagkagtrqlgdGWTVVTQDGSWS 232
Cdd:cd01087  155 deIVESGAYAKFFPHGLGhylglDV-HDVGGYLRYLRRAR--PLEPGMVITIEP--------------GIYFIPDLLDVP 217

                        250       260
                 ....*....|....*....|....*
gi 759931048 233 AQW-------EHMVAVTDDGFEVLT 250
Cdd:cd01087  218 EYFrgggiriEDDVLVTEDGPENLT 242
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 12-160 6.37e-12

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 63.50  E-value: 6.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  12 VAKAREAGKLVAELLAMIGEHVKPGVSTEEL----DARCNEYIVKVQKAKPANVGYYGYPKTIcsSVNQVVCHGIP---S 84
Cdd:cd01089    1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLcekgDKLILEELGKVYKKEKKLEKGIAFPTCI--SVNNCVCHFSPlksD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  85 AKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAE-----AKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITE 159
Cdd:cd01089   79 ATYTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETpvtgkKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIV 158


                 .
gi 759931048 160 S 160
Cdd:cd01089  159 D 159
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 33-213 4.64e-10

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 59.34  E-value: 4.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  33 VKPGVS----TEELDARCNEYIvkvqKAKPANVGYyGYPkTICSsVNQVVCHGIPSA--KQILRDGDIVNIDVAVIKNGW 106
Cdd:PTZ00053 179 IKPGVKlidiCERIESKSRELI----EADGLKCGW-AFP-TGCS-LNHCAAHYTPNTgdKTVLTYDDVCKLDFGTHVNGR 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 107 HGDSSrmFYVGRpSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAGFSV---------VREYCGHGIGKv 177
Cdd:PTZ00053 252 IIDCA--FTVAF-NPKYDPLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYEVEIkgktypiksIRNLNGHSIGP- 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 759931048 178 YHeepevLHYG------RPGIGMKLKRGMVFTIEPMINAGKA 213
Cdd:PTZ00053 328 YI-----IHGGksvpivKGGENTRMEEGELFAIETFASTGRG 364
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 6-172 2.52e-09

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 57.21  E-value: 2.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048    6 IKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEEL----DARCNEYIVKV-QKAKPANVGYyGYPKtiCSSVNQVVCH 80
Cdd:TIGR00495  14 LSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDIcekgDAFIMEETAKIfKKEKEMEKGI-AFPT--CISVNNCVGH 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   81 GIPSA---KQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAE-----AKRLVETCYDATCAGIRAVRPGATLGDIGH 152
Cdd:TIGR00495  91 FSPLKsdqDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEpvtgrKADVIAAAHLAAEAALRLVKPGNTNTQVTE 170

                         170       180
                  ....*....|....*....|
gi 759931048  153 AIQAITESAGFSVVREYCGH 172
Cdd:TIGR00495 171 AINKVAHSYGCTPVEGMLSH 190
PRK15173 PRK15173
peptidase; Provisional
 5-256 5.68e-07

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 49.72  E-value: 5.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   5 VIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPA-----NVGYYGYPKTICSsvNQVVC 79
Cdd:PRK15173  94 VIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSrfhliSVGADFSPKLIPS--NTKAC 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  80 hgipsakqilrDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITE 159
Cdd:PRK15173 172 -----------SGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIK 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 160 SAGF-SVVREYCGHGIGKV--YHEEPEVLHYGRPgigmKLKRGMVFTIEPMINAGKAGtrqlgdgwtvvtqdgswSAQWE 236
Cdd:PRK15173 241 KSGLpNYNRGHLGHGNGVFlgLEESPFVSTHATE----SFTSGMVLSLETPYYGYNLG-----------------SIMIE 299

                        250       260
                 ....*....|....*....|
gi 759931048 237 HMVAVTDDGFEVLTPWPDGL 256
Cdd:PRK15173 300 DMILINKEGIEFLSKLPRDL 319
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 5-206 8.56e-07

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 49.34  E-value: 8.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   5 VIKSPAEVAKAREAGKL--VAELLAMigEHVKPGVSTEELDARCNEYIVKvQKAKpanvgYYGYPKTICSSVNQVVCHGI 82
Cdd:PRK10879 172 LFKSPEEIAVLRRAGEIsaLAHTRAM--EKCRPGMFEYQLEGEIHHEFNR-HGAR-----YPSYNTIVGSGENGCILHYT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  83 PSAKQiLRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVetcYDATCA----GIRAVRPGATLGDI-------- 150
Cdd:PRK10879 244 ENESE-MRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREI---YDIVLEsletSLRLYRPGTSIREVtgevvrim 319

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759931048 151 -----------GHAIQAITESAGFSVVREYCGHGIGKVYHeepEVLHYGrPGIGMKLKRGMVFTIEP 206
Cdd:PRK10879 320 vsglvklgilkGDVDQLIAENAHRPFFMHGLSHWLGLDVH---DVGVYG-QDRSRILEPGMVLTVEP 382
PRK14576 PRK14576
putative endopeptidase; Provisional
 5-250 8.66e-07

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 49.24  E-value: 8.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   5 VIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKvqkakpanvgyygYPKTICSSVNQVVCHGIPS 84
Cdd:PRK14576 176 MIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMS-------------FPETNFSRFNLISVGDNFS 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  85 AKQI-----LRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITE 159
Cdd:PRK14576 243 PKIIadttpAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIK 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 160 SAGFS-VVREYCGHGIGKV--YHEEPEVLHYGRPgigmKLKRGMVFTIEpminagkagtrqlgdgwTVVTQDGSWSAQWE 236
Cdd:PRK14576 323 TSGLPhYNRGHLGHGDGVFlgLEEVPFVSTQATE----TFCPGMVLSLE-----------------TPYYGIGVGSIMLE 381

                        250
                 ....*....|....
gi 759931048 237 HMVAVTDDGFEVLT 250
Cdd:PRK14576 382 DMILITDSGFEFLS 395
PRK14575 PRK14575
putative peptidase; Provisional
 5-256 1.01e-06

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 49.32  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048   5 VIKSPAEVAKAREAGKLVAELLAMIGEHVKPGVSTEELDARCNEYIVKVQKAKPA-----NVGYYGYPKTICSsvNQVVC 79
Cdd:PRK14575 177 VIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSrfhliSVGADFSPKLIPS--NTKAC 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  80 hgipsakqilrDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITE 159
Cdd:PRK14575 255 -----------SGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIK 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 160 SAGF-SVVREYCGHGIGKV--YHEEPEVLHYGRPgigmKLKRGMVFTIEPMINAGKAGtrqlgdgwtvvtqdgswSAQWE 236
Cdd:PRK14575 324 KSGLpNYNRGHLGHGNGVFlgLEESPFVSTHATE----SFTSGMVLSLETPYYGYNLG-----------------SIMIE 382

                        250       260
                 ....*....|....*....|
gi 759931048 237 HMVAVTDDGFEVLTPWPDGL 256
Cdd:PRK14575 383 DMILINKEGIEFLSKLPRDL 402
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 83-208 1.32e-04

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 42.14  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048  83 PSAKQILRDGDIVNIDVAVIKNGWHGDSSRMFYVGRPSAEAKRLVETCYDATCAGIRAVRPGATLGDIGHAIQAITESAG 162
Cdd:cd01090   71 PVTNRKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARCKDIAAELNEMYREHD 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 759931048 163 FSVVREY-CGHGIGKVYHeepevlHYGRPG-------IGMKLKRGMVFTIEPMI 208
Cdd:cd01090  151 LLRYRTFgYGHSFGVLSH------YYGREAglelredIDTVLEPGMVVSMEPMI 198
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 109-206 7.38e-04

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 39.85  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931048 109 DSSRMFYVGRPSAEAKRlvetCYDATCAGI----RAVRP-GATlgdiGHAIQAITESAGFSVVREY---CGHGIG---KV 177
Cdd:cd01085   99 DITRTVHLGEPTAEQKR----DYTLVLKGHialaRAKFPkGTT----GSQLDALARQPLWKAGLDYghgTGHGVGsflNV 170

                         90       100
                 ....*....|....*....|....*....
gi 759931048 178 yHEEPEVLhYGRPGiGMKLKRGMVFTIEP 206
Cdd:cd01085  171 -HEGPQSI-SPAPN-NVPLKAGMILSNEP 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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