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Conserved domains on  [gi|759931435|ref|WP_043616725|]
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helix-turn-helix transcriptional regulator [Chromobacterium violaceum]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398449)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 19-111 3.70e-31

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 110.74  E-value: 3.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  19 VIGIAADMG-VHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHRALMRGVVAYRSLYFAPEL--PF 95
Cdd:cd06124    1 VLARAADYPaGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAaaGL 80

                         90
                 ....*....|....*.
gi 759931435  96 PAPPlQVLEVNPLLRE 111
Cdd:cd06124   81 PAEP-CVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
170-251 1.73e-20

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 1.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435   170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETP 248
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 759931435   249 ARY 251
Cdd:smart00342  81 SEY 83
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 19-111 3.70e-31

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 110.74  E-value: 3.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  19 VIGIAADMG-VHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHRALMRGVVAYRSLYFAPEL--PF 95
Cdd:cd06124    1 VLARAADYPaGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAaaGL 80

                         90
                 ....*....|....*.
gi 759931435  96 PAPPlQVLEVNPLLRE 111
Cdd:cd06124   81 PAEP-CVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
170-251 1.73e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 1.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435   170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETP 248
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 759931435   249 ARY 251
Cdd:smart00342  81 SEY 83
HTH_18 pfam12833
Helix-turn-helix domain;
176-254 1.94e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.64  E-value: 1.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  176 LADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLAD--GMGASETAQRLAFASDSAFIAFFRQHTGETPARYAQ 253
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 759931435  254 S 254
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
12-258 8.45e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 85.60  E-value: 8.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  12 ADAFDAPVIGIAADMGVHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHRALMRGVVAYRSLYFAP 91
Cdd:COG2207   10 LLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  92 ELPFPAPPLQVLEVNPLLREVIERMAFWPWDEPAERQRSLLAVFGEELLAAKGENWRLPFPKDARLSSWLDGVRGGALPP 171
Cdd:COG2207   90 LLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 172 RLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETPAR 250
Cdd:COG2207  170 TLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249


                 ....*...
gi 759931435 251 YAQSRVSR 258
Cdd:COG2207  250 YRKRLRAR 257
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 170-258 1.25e-12

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 66.62  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADGMGASETAQRLAFASDSAFIAFFRQHTGETPA 249
Cdd:COG2169  100 RPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPS 179


                 ....*....
gi 759931435 250 RYAQSRVSR 258
Cdd:COG2169  180 AYRRGGAGA 188
ftrA PRK09393
transcriptional activator FtrA; Provisional
 150-251 6.52e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 6.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 150 PFPKD--ARLSSWLDGVRGG-ALPPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELL-ADGMGASETA 225
Cdd:PRK09393 211 PVASResDRLGPLIDWMRAHlAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIA 290

                         90       100
                 ....*....|....*....|....*.
gi 759931435 226 QRLAFASDSAFIAFFRQHTGETPARY 251
Cdd:PRK09393 291 ERAGFGSEESLRHHFRRRAATSPAAY 316
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 19-117 1.26e-03

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 38.18  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435   19 VIGIAADMGVHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHR--ALMRGVVAYRSLYFAPEL--- 93
Cdd:pfam02311   4 LEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDyePESEDGWRYRWLYFEPELler 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 759931435   94 ---------PFPAPPLQVLEVNPLLREVIERMA 117
Cdd:pfam02311  84 iladisilaGGPLPLLRDPELAALLRALFRLLE 116
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 19-111 3.70e-31

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 110.74  E-value: 3.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  19 VIGIAADMG-VHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHRALMRGVVAYRSLYFAPEL--PF 95
Cdd:cd06124    1 VLARAADYPaGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAaaGL 80

                         90
                 ....*....|....*.
gi 759931435  96 PAPPlQVLEVNPLLRE 111
Cdd:cd06124   81 PAEP-CVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
170-251 1.73e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 1.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435   170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETP 248
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 759931435   249 ARY 251
Cdd:smart00342  81 SEY 83
HTH_18 pfam12833
Helix-turn-helix domain;
176-254 1.94e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.64  E-value: 1.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  176 LADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLAD--GMGASETAQRLAFASDSAFIAFFRQHTGETPARYAQ 253
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 759931435  254 S 254
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
12-258 8.45e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 85.60  E-value: 8.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  12 ADAFDAPVIGIAADMGVHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHRALMRGVVAYRSLYFAP 91
Cdd:COG2207   10 LLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435  92 ELPFPAPPLQVLEVNPLLREVIERMAFWPWDEPAERQRSLLAVFGEELLAAKGENWRLPFPKDARLSSWLDGVRGGALPP 171
Cdd:COG2207   90 LLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 172 RLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETPAR 250
Cdd:COG2207  170 TLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249


                 ....*...
gi 759931435 251 YAQSRVSR 258
Cdd:COG2207  250 YRKRLRAR 257
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 170-258 1.25e-12

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 66.62  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADGMGASETAQRLAFASDSAFIAFFRQHTGETPA 249
Cdd:COG2169  100 RPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPS 179


                 ....*....
gi 759931435 250 RYAQSRVSR 258
Cdd:COG2169  180 AYRRGGAGA 188
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 170-251 1.45e-11

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 63.25  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETP 248
Cdd:COG4977  226 PLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLSIEEIAAACGFGSASHFRRAFRRRFGVSP 305


                 ...
gi 759931435 249 ARY 251
Cdd:COG4977  306 SAY 308
ftrA PRK09393
transcriptional activator FtrA; Provisional
 150-251 6.52e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 6.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 150 PFPKD--ARLSSWLDGVRGG-ALPPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELL-ADGMGASETA 225
Cdd:PRK09393 211 PVASResDRLGPLIDWMRAHlAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIA 290

                         90       100
                 ....*....|....*....|....*.
gi 759931435 226 QRLAFASDSAFIAFFRQHTGETPARY 251
Cdd:PRK09393 291 ERAGFGSEESLRHHFRRRAATSPAAY 316
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
183-258 1.63e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 42.20  E-value: 1.63e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759931435 183 SERTISRIFIRDTGMSYQAWRQQWRLLRAMELL-ADGMGASETAQRLAFASDSAFIAFFRQHTGETPARYAQSRVSR 258
Cdd:PRK13501 205 VERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLrGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRFIRS 281
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 29-75 2.25e-04

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 38.53  E-value: 2.25e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 759931435  29 HDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHR 75
Cdd:cd07003    5 HDQSSHSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHR 51
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 192-255 2.27e-04

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 41.45  E-value: 2.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759931435 192 IRDTGMSYQAWRQQWRLLRAMELLA-DGMGASETAQRLAFASDSAFIAFFRQHTGETPARYAQSR 255
Cdd:PRK09978 179 LREEETSYSQLLTECRMQRALQLIViHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERS 243
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
170-251 3.44e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 41.24  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETP 248
Cdd:PRK13500 222 PFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSrLLISDISTECGFEDSNYFSVVFTRETGMTP 301


                 ...
gi 759931435 249 ARY 251
Cdd:PRK13500 302 SQW 304
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
170-251 3.94e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 40.93  E-value: 3.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADGMGASETAQRLAFASDSAFIAFFRQHTGETPA 249
Cdd:PRK15435  99 PVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAKGESVTTSILNAGFPDSSSYYRKADETLGMTAK 178


                 ..
gi 759931435 250 RY 251
Cdd:PRK15435 179 QF 180
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
29-75 8.67e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.91  E-value: 8.67e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 759931435  29 HDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHR 75
Cdd:COG1917   34 ARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHA 80
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 19-117 1.26e-03

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 38.18  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435   19 VIGIAADMGVHDSGRHCHQRHQLLFAAAGCITIELADTLCLLPPSRAAWIPAGTAHR--ALMRGVVAYRSLYFAPEL--- 93
Cdd:pfam02311   4 LEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDyePESEDGWRYRWLYFEPELler 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 759931435   94 ---------PFPAPPLQVLEVNPLLREVIERMA 117
Cdd:pfam02311  84 iladisilaGGPLPLLRDPELAALLRALFRLLE 116
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
170-251 2.16e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 38.50  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759931435 170 PPRLNQLADRAGASERTISRIFIRDTGMSYQAWRQQWRLLRAMELLADG-MGASETAQRLAFASDSAFIAFFRQHTGETP 248
Cdd:PRK13502 192 PFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSpLMISEISMQCGFEDSNYFSVVFTRETGMTP 271


                 ...
gi 759931435 249 ARY 251
Cdd:PRK13502 272 SQW 274
cupin_QdtA-like cd20292
sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin ...
 32-75 4.94e-03

sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin domains of several bacterial proteins homologous to sugar 3,4-ketoisomerases. Thermoanaerobacterium thermosaccharolyticum QdtA catalyzes a key step in the biosynthesis of these sugars, the conversion of thymidine diphosphate (dTDP)-4-keto-6-deoxyglucose to dTDP-3-keto-6-deoxyglucose. In Aneurinibacillus thermoaerophilus, TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (also known as FdtA) is involved in the biosynthesis of dTDP-Fucp3NAc (3-acetamido-3,6-dideoxy-alpha-d-galactose), which is part of the repeating units of the glycan chain in the S-layer. Shewanella denitrificans bifunctional ketoisomerase/N-acetyltransferase (also known as FdtD) is involved in the third and fifth steps in the production of 3-acetamido-3,6-dideoxy-alpha-d-galactose or Fuc3NAc; the C-terminal cupin domain harbors the active site responsible for the isomerization reaction. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380426  Cd Length: 117  Bit Score: 35.91  E-value: 4.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 759931435  32 GRHCHQR-HQLLFAAAGCITIELAD-----TLCLLPPSRAAWIPAGTAHR 75
Cdd:cd20292   43 GGHAHKKlEQLLICLSGSCEVILDDgkekeEFVLDSPNKGLYIPPGVWHE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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