NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|762767832|ref|WP_043881801|]
View 

MULTISPECIES: SLC13 family permease [Pectobacterium]

Protein Classification

SLC13 family permease( domain architecture ID 11422084)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Gene Ontology:  GO:0016020|GO:0015293|GO:0006811|GO:0055085|GO:0022857
PubMed:  23177988|24114175|23506872
SCOP:  4006109
TCDB:  2.A.47

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 3.30e-61

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 207.31  E-value: 3.30e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  61 AALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARM-----KISPGR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 136 LMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGFGFFSVTPIGIVVLLLGVAYMMVARYWLggaetatakemwkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRL--------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 216 tfrdlirdyrltgrarrlairpgspfighrlddlrlrqrfganvvgierwrkFRRVMISVAGNTELrlndvllidmsase 295
Cdd:COG0471  146 ----------------------------------------------------LPPEIKEVPGSKEV-------------- 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 296 vdlrefctaqrlepmvlrgeyfseqardvgmaevslipdsellgktlydvgfrsryglsvvgIRRAGEAMEGILADEPLq 375
Cdd:COG0471  160 --------------------------------------------------------------IREELAELGPLSRREKI- 176

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 376 lgdillvmgdwrmirqlhtqkndflllnlpaevddvapavsqaphALFCLALMVAMMLTDE---IPNAVAALIACLLMGK 452
Cdd:COG0471  177 ---------------------------------------------ALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 453 FRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDAGPHVMLVCLFVLCAVIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 762767832 533 APIAIAAAKQMGVSPYPFAMIIAIAASAAFMTPVSSPVNTLVLGPGGYKFGDFVRVGVPFTVLVMLVSVVMVPWLYPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 304-392 1.56e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 68.02  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 304 AQRLEPMVLRGEYFSEQARDVGMAEVSLIPDSELLGKTLYDVGFRSRYGLSVVGIRRAGEAMEGILADEPLQLGDILLVM 383
Cdd:COG0490   48 LLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVV 127


                 ....*....
gi 762767832 384 GDWRMIRQL 392
Cdd:COG0490  128 GTREQLERL 136
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 2.70e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


:

Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.69  E-value: 2.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832  231 RRLAIRPGSPFIGHRLDDLRLRQRFGANVVGIERwrkfRRVMISVAGNTELRLNDVLLIDMSASEVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR----GGRLIIPSGDTVLEAGDRLLVIGTPDDLA 64
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 3.30e-61

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 207.31  E-value: 3.30e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  61 AALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARM-----KISPGR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 136 LMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGFGFFSVTPIGIVVLLLGVAYMMVARYWLggaetatakemwkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRL--------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 216 tfrdlirdyrltgrarrlairpgspfighrlddlrlrqrfganvvgierwrkFRRVMISVAGNTELrlndvllidmsase 295
Cdd:COG0471  146 ----------------------------------------------------LPPEIKEVPGSKEV-------------- 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 296 vdlrefctaqrlepmvlrgeyfseqardvgmaevslipdsellgktlydvgfrsryglsvvgIRRAGEAMEGILADEPLq 375
Cdd:COG0471  160 --------------------------------------------------------------IREELAELGPLSRREKI- 176

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 376 lgdillvmgdwrmirqlhtqkndflllnlpaevddvapavsqaphALFCLALMVAMMLTDE---IPNAVAALIACLLMGK 452
Cdd:COG0471  177 ---------------------------------------------ALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 453 FRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDAGPHVMLVCLFVLCAVIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 762767832 533 APIAIAAAKQMGVSPYPFAMIIAIAASAAFMTPVSSPVNTLVLGPGGYKFGDFVRVGVPFTVLVMLVSVVMVPWLYPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 14-203 2.52e-51

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 181.24  E-value: 2.52e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  14 IAIVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMK 93
Cdd:cd01115    6 FAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  94 MLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGF 173
Cdd:cd01115   86 LLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGF 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 762767832 174 GFFSVTPIGIVVLLLGVAYMMVARYWLGGA 203
Cdd:cd01115  166 SFFEFTPIGLPLLIIGLLYLWFIFRLAVLI 195
CitMHS pfam03600
Citrate transporter;
16-200 4.21e-41

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 152.47  E-value: 4.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   16 IVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKML 95
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   96 ILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGvAGFGF 175
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSF-GDFGF 159

                         170       180
                  ....*....|....*....|....*
gi 762767832  176 FSVTPIGIVVLLLGVAYMMVARYWL 200
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKL 184
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 15-188 1.69e-15

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 78.93  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   15 AIVLFTTNKLRMDVVALLVI-IAFVLSGTLTL---SEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSG 90
Cdd:TIGR00785  20 AIVGWILEPLPLPVTALLAIpIIAVLLGVLSAfkfKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   91 EMKM-LILLMVTVALLGAFMSSTGVV-AIFIPVVLSVSARMKISPGR--------LMMPLSFAGLISGMMTLVATPPNMV 160
Cdd:TIGR00785 100 TLGLgYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTGSAPNAL 179

                         170       180       190
                  ....*....|....*....|....*....|..
gi 762767832  161 VSSELMREGVAGFGFFS----VTPIGIVVLLL 188
Cdd:TIGR00785 180 AAGILSKILGIQISWGDwflaGLPLGIILLLL 211
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 304-392 1.56e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 68.02  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 304 AQRLEPMVLRGEYFSEQARDVGMAEVSLIPDSELLGKTLYDVGFRSRYGLSVVGIRRAGEAMEGILADEPLQLGDILLVM 383
Cdd:COG0490   48 LLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVV 127


                 ....*....
gi 762767832 384 GDWRMIRQL 392
Cdd:COG0490  128 GTREQLERL 136
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-392 2.72e-10

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 56.46  E-value: 2.72e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832  326 MAEVSLIPDSELLGKTLYDVGFRSRYGLSVVGIRRaGEAMEGILADEPLQLGDILLVMGDWRMIRQL 392
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR-GGRLIIPSGDTVLEAGDRLLVIGTPDDLAAL 66
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 2.70e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.69  E-value: 2.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832  231 RRLAIRPGSPFIGHRLDDLRLRQRFGANVVGIERwrkfRRVMISVAGNTELRLNDVLLIDMSASEVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR----GGRLIIPSGDTVLEAGDRLLVIGTPDDLA 64
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 181-289 4.19e-08

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 52.62  E-value: 4.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 181 IGIVVLLLGVAYMMVARYWLGGAETATAKEMWKRRTFRDLIRDYRLTgRARRLAIRPGSPFIGHRLDDLRLRQRFGANVV 260
Cdd:COG0490   22 LVAIVIVGVLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLL-AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVV 100

                         90       100
                 ....*....|....*....|....*....
gi 762767832 261 GIERwrkFRRVMISVAGNTELRLNDVLLI 289
Cdd:COG0490  101 AIRR---GGEVILSPGPDTVLEAGDTLVV 126
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 3.30e-61

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 207.31  E-value: 3.30e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  61 AALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARM-----KISPGR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 136 LMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGFGFFSVTPIGIVVLLLGVAYMMVARYWLggaetatakemwkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRL--------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 216 tfrdlirdyrltgrarrlairpgspfighrlddlrlrqrfganvvgierwrkFRRVMISVAGNTELrlndvllidmsase 295
Cdd:COG0471  146 ----------------------------------------------------LPPEIKEVPGSKEV-------------- 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 296 vdlrefctaqrlepmvlrgeyfseqardvgmaevslipdsellgktlydvgfrsryglsvvgIRRAGEAMEGILADEPLq 375
Cdd:COG0471  160 --------------------------------------------------------------IREELAELGPLSRREKI- 176

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 376 lgdillvmgdwrmirqlhtqkndflllnlpaevddvapavsqaphALFCLALMVAMMLTDE---IPNAVAALIACLLMGK 452
Cdd:COG0471  177 ---------------------------------------------ALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 453 FRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDAGPHVMLVCLFVLCAVIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 762767832 533 APIAIAAAKQMGVSPYPFAMIIAIAASAAFMTPVSSPVNTLVLGPGGYKFGDFVRVGVPFTVLVMLVSVVMVPWLYPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 14-203 2.52e-51

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 181.24  E-value: 2.52e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  14 IAIVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMK 93
Cdd:cd01115    6 FAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  94 MLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGF 173
Cdd:cd01115   86 LLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGF 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 762767832 174 GFFSVTPIGIVVLLLGVAYMMVARYWLGGA 203
Cdd:cd01115  166 SFFEFTPIGLPLLIIGLLYLWFIFRLAVLI 195
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 418-608 3.78e-44

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 161.60  E-value: 3.78e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 418 APHALFCLALMVAMMLTDEI---PNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVK 494
Cdd:cd01115  189 FRLAVLIITIVLLAALAAITgllPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 495 GLMDVAGDAGPHVMLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAASAAFMTPVSSPVNTLV 574
Cdd:cd01115  269 ALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIV 348

                        170       180       190
                 ....*....|....*....|....*....|....
gi 762767832 575 LGPGGYKFGDFVRVGVPFTVLVMLVSVVMVPWLY 608
Cdd:cd01115  349 LGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
16-200 4.21e-41

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 152.47  E-value: 4.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   16 IVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKML 95
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   96 ILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGvAGFGF 175
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSF-GDFGF 159

                         170       180
                  ....*....|....*....|....*
gi 762767832  176 FSVTPIGIVVLLLGVAYMMVARYWL 200
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKL 184
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 16-593 1.80e-29

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 120.43  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  16 IVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGsGEMKML 95
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASK-GSRRLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  96 ILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPG-RLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGFG 174
Cdd:cd00625   80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPvPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLDFLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 175 FFSVTPIGIVVLLLGVAYMMVARYWLggaetatakemwkrrtfrdlirdyrltgrarrlairpgspfighrLDDLRLRQR 254
Cdd:cd00625  160 FMAPPALGLLLLLLGLLYLLFRKKLL---------------------------------------------LPDEDKLTV 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 255 FGANVVGIERWRKFRRVMIsvagntelrlndvllidmsasevdlrefctaqrlepmvlrgeyfseqardvgmaevslipd 334
Cdd:cd00625  195 LAEPLPARPLLKKFLLLAL------------------------------------------------------------- 213

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 335 sellgktlydvgfrsryglsvvgirrageamegiladeplqlgdillvmgdwrmirqlhtqkndflllnlpaevddvapa 414
Cdd:cd00625      --------------------------------------------------------------------------------

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 415 vsqaphalFCLALMVAMMLTDEIPNAVAALIAC-LLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIV 493
Cdd:cd00625  214 --------LLLLLFVLLFFFLIPLGLIALLGALlLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLA 285

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 494 KGLMDVAGdAGPHVMLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAK-----QMGVSPYPFAMIIAIAASAAFMTPVSS 568
Cdd:cd00625  286 ELLVALVG-LPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPpepawLALALGSTLGGNLTLIGSLANLIPLGA 364

                        570       580
                 ....*....|....*....|....*
gi 762767832 569 PVNTLVlgpgGYKFGDFVRVGVPFT 593
Cdd:cd00625  365 AENAGV----GISFGEFLKVGLPLT 385
CitMHS pfam03600
Citrate transporter;
405-547 8.25e-21

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 93.92  E-value: 8.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  405 PAEVDDVAPAVSQAPHALFCLALMVAMMLTDEIPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQ 484
Cdd:pfam03600 192 EAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALE 271

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 762767832  485 QTGGVTLIVKGLMDVagdAGPHVMLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSP 547
Cdd:pfam03600 272 KTGLADALADALGGL---SGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
CitMHS pfam03600
Citrate transporter;
429-591 2.11e-16

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 80.82  E-value: 2.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  429 VAMMLTDEIPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDaGPHVM 508
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGG-KPRRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  509 LVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAASAAF-MTPVSSPVNTLVLGPGGYKFGDFVR 587
Cdd:pfam03600  80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGtATPIGDPPNIIIASALGLSFGDFGF 159


                  ....
gi 762767832  588 VGVP 591
Cdd:pfam03600 160 FMFP 163
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
28-200 6.14e-16

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 79.81  E-value: 6.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  28 VVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVR-VAGSGEMKMLILLMVTVALLG 106
Cdd:COG0471  200 VVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLT 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 107 AFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLiSGMMTLVATPPNMVVsselmrEGVAGFGFFSVTPIGIVVL 186
Cdd:COG0471  280 EFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAAS-CAFLLPVGTPPNAIV------YGSGYYKFKDFLKVGLPLN 352

                        170
                 ....*....|....
gi 762767832 187 LLGVAYMMVARYWL 200
Cdd:COG0471  353 LIGLVVLLLLGPLW 366
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 15-188 1.69e-15

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 78.93  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   15 AIVLFTTNKLRMDVVALLVI-IAFVLSGTLTL---SEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSG 90
Cdd:TIGR00785  20 AIVGWILEPLPLPVTALLAIpIIAVLLGVLSAfkfKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   91 EMKM-LILLMVTVALLGAFMSSTGVV-AIFIPVVLSVSARMKISPGR--------LMMPLSFAGLISGMMTLVATPPNMV 160
Cdd:TIGR00785 100 TLGLgYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTGSAPNAL 179

                         170       180       190
                  ....*....|....*....|....*....|..
gi 762767832  161 VSSELMREGVAGFGFFS----VTPIGIVVLLL 188
Cdd:TIGR00785 180 AAGILSKILGIQISWGDwflaGLPLGIILLLL 211
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
421-588 7.15e-15

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 77.09  E-value: 7.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 421 ALFCLALMVAMMLTDEIPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVA 500
Cdd:COG1055    7 AIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 501 GdAGPHVMLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAA-SAAFMTPVSSPVNTLVLGPGG 579
Cdd:COG1055   87 K-GSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAAnIGGAATPIGNPTNIMIASAGG 165


                 ....*....
gi 762767832 580 YKFGDFVRV 588
Cdd:COG1055  166 LSFLDFLAN 174
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
14-219 7.75e-15

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 76.71  E-value: 7.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  14 IAIVLFTTNKLRMD--VVALLVIIAFVLSGTLTLSEALVGFsDPNVI-LIAALFVIGEGLVRTGVAYQVGDWLVRVAGSG 90
Cdd:COG1055   11 LTYLLIILEPRGLNraVAALLGAALLLLLGVVSLEDALEAI-DWNTIlFLLGMMIIVAILDESGFFEWLAIKLARRAKGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  91 EMKMLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMregv 170
Cdd:COG1055   90 PRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMIASAGG---- 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 762767832 171 AGFGFFSVTPIGIVVLLLGVAYMMVARYWLGGAETATAKEMWKRRTFRD 219
Cdd:COG1055  166 LSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLEDDPKEAIKD 214
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 430-610 5.47e-14

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 74.21  E-value: 5.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 430 AMMLTDEIPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGdaGPHVML 509
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASK--GSRRLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 510 VCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAASAA--FMTPVSSPVNTLVLGPGGYKFGDFVR 587
Cdd:cd00625   80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIggAATPIGNPPNLIIASLSGLGFLDFLA 159

                        170       180
                 ....*....|....*....|...
gi 762767832 588 VGVPFTVLVMLVSVVMVPWLYPF 610
Cdd:cd00625  160 FMAPPALGLLLLLLGLLYLLFRK 182
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 304-392 1.56e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 68.02  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 304 AQRLEPMVLRGEYFSEQARDVGMAEVSLIPDSELLGKTLYDVGFRSRYGLSVVGIRRAGEAMEGILADEPLQLGDILLVM 383
Cdd:COG0490   48 LLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVV 127


                 ....*....
gi 762767832 384 GDWRMIRQL 392
Cdd:COG0490  128 GTREQLERL 136
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 15-201 8.38e-13

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 70.31  E-value: 8.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  15 AIVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVA-GSGEMK 93
Cdd:cd01115  202 AALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLgGLPPFA 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  94 MLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGlISGMMTLVATPPNMVVSSElmregvAGF 173
Cdd:cd01115  282 ILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGA-SCAFMLPVGTPPNAIVLGP------GGY 354

                        170       180
                 ....*....|....*....|....*...
gi 762767832 174 GFFSVTPIGIVVLLLGVAYMMVARYWLG 201
Cdd:cd01115  355 KFSDFAKVGLPLSILSLVVSVTMIPLIW 382
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 425-591 2.86e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 68.77  E-value: 2.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 425 LALMVAMMLTDEIPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDaG 504
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGK-G 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 505 PHVMLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYP-FAMIIAIAASAAFMTPVSSPVNTLV------LGP 577
Cdd:cd01115   83 ERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRlLMPLAFAASIGGMLTLIGTPPNLVAsgylesLGG 162

                        170
                 ....*....|....
gi 762767832 578 GGYKFGDFVRVGVP 591
Cdd:cd01115  163 QGFSFFEFTPIGLP 176
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 28-192 4.62e-12

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 68.52  E-value: 4.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   28 VVALLVIIAFVLSGTLTLSEALVGFSDPNV-ILIAALFVIGEGLVRTGVAYQVGDWLVRVAG--SGEMKMLILLMVTVAL 104
Cdd:TIGR00785 274 VVALLAVVLMLFLGIVTWKDIQKNKVAWNTlILFGGLIGLAGGLKKSGFIKWFSEKLVGILDglSPTIAVLVLVVLFYII 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  105 LGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVV-------SSELMREGvAGFGFFS 177
Cdd:TIGR00785 354 LYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyvkIKDMWRVG-AIIGIVG 432

                         170
                  ....*....|....*
gi 762767832  178 VtpigIVVLLLGVAY 192
Cdd:TIGR00785 433 L----IVLLLVGTLW 443
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 28-193 1.05e-10

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 63.81  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  28 VVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTVALLGA 107
Cdd:cd00625  233 ALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 108 FMSSTGVVAIFIPVVLSVSArmkisPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVA-GFG-FFSVT-PIGIV 184
Cdd:cd00625  313 FISNVPTVALLLPIAASLAP-----PEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGiSFGeFLKVGlPLTLL 387


                 ....*....
gi 762767832 185 VLLLGVAYM 193
Cdd:cd00625  388 SLVVSLLYL 396
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
17-386 1.11e-10

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 63.92  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  17 VLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLI 96
Cdd:COG3273   22 EMKDTAELLIDLAYSAVLDESDALAEEVLELELRMDVLQLLARMSLLLAARALEEAELLAPVLGVVAAAVAISAAAGDIA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  97 LLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAGFGFF 176
Cdd:COG3273  102 KVVLEDIGLPEAMRAALPEAVETLVRATVAASSALAGRTLLLILLETETGVRVIAIRRGDDWLLNPGPTTILRADDLVLL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 177 SVTPIGIVVLLLGVAYMMVARYwlgGAETATAKEMWKRRTFRDLIRDYRLTGRARRLAIRpgSPFIGHRLDDLRLRQRFG 256
Cdd:COG3273  182 RGPEGGILEVYLAATGDLYERP---RPPEDSIVEMKNLSELAVDLAYSSVLFDSEELAEE--VRELEEEVDALKSRLEAW 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 257 ANVVGIERWRKFR-RVMISVAGNTELRLNDVLLIdmsaSEVDLREFctaqRLEPMVLRgeyfSEQARDVGMAEVSLIPDS 335
Cdd:COG3273  257 VLRAARRVDDPVAlRGLLHLASSTEVISDAALDI----AEGVLRGL----EDHPVVAE----AVRESDERIVRVTVPPGS 324

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 762767832 336 ELLGKTLYDVGFRSRYGLSVVGIRRAGEAMEGILADEPLQLGDILLVMGDW 386
Cdd:COG3273  325 PLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTR 375
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 28-201 1.57e-10

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 63.07  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  28 VVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTvALLGA 107
Cdd:cd01117   15 AIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRLLFLLVLLS-GILSA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 108 FMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSelmrEGVAGFGFFSVTPIGIVVLL 187
Cdd:cd01117   94 LLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIAS----ESGISFPFFLAAMAPLALLG 169

                        170
                 ....*....|....
gi 762767832 188 LGVAYMMVARYWLG 201
Cdd:cd01117  170 LLLLLILLLVLFPG 183
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 437-593 2.24e-10

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 63.13  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  437 IPNAVAALIACLLMGKFRCIDMESAYR-AIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDV-AGDAGPHVMLVCLFV 514
Cdd:TIGR00785 270 INASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGIlDGLSPTIAVLVLVVL 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  515 LCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAA-SAAFMTPVSSPVNTLVLGPGGYKFGDFVRVGVPFT 593
Cdd:TIGR00785 350 FYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAsLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIG 429
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-392 2.72e-10

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 56.46  E-value: 2.72e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832  326 MAEVSLIPDSELLGKTLYDVGFRSRYGLSVVGIRRaGEAMEGILADEPLQLGDILLVMGDWRMIRQL 392
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR-GGRLIIPSGDTVLEAGDRLLVIGTPDDLAAL 66
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 436-610 4.81e-09

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 58.44  E-value: 4.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 436 EIPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDAGPHVMLVCLfvL 515
Cdd:cd01117   10 RLDRWAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRLLFLLVL--L 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 516 CAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAASA-AFMTPVSSPVNTLVLGPGGYKFGDFVRVGVPFTV 594
Cdd:cd01117   88 SGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIgSAATPIGNPQNLLIASESGISFPFFLAAMAPLAL 167

                        170
                 ....*....|....*.
gi 762767832 595 LVMLVSVVMVPWLYPF 610
Cdd:cd01117  168 LGLLLLLILLLVLFPG 183
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 14-194 9.06e-09

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 58.03  E-value: 9.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  14 IAIVLFTTN---KLRMDVVALL-VIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGS 89
Cdd:cd01116  226 LVIIGFVLHsplGVSLGWIALLgALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  90 GEMKMLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSELMREG 169
Cdd:cd01116  306 RIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHG 385

                        170       180
                 ....*....|....*....|....*...
gi 762767832 170 --VAGFGFFSVT-PIGIVVLLLGVAYMM 194
Cdd:cd01116  386 ykISFWEFLKVGfPIMLVSLILATVYLL 413
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 2.70e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.69  E-value: 2.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832  231 RRLAIRPGSPFIGHRLDDLRLRQRFGANVVGIERwrkfRRVMISVAGNTELRLNDVLLIDMSASEVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR----GGRLIIPSGDTVLEAGDRLLVIGTPDDLA 64
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 181-289 4.19e-08

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 52.62  E-value: 4.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 181 IGIVVLLLGVAYMMVARYWLGGAETATAKEMWKRRTFRDLIRDYRLTgRARRLAIRPGSPFIGHRLDDLRLRQRFGANVV 260
Cdd:COG0490   22 LVAIVIVGVLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLL-AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVV 100

                         90       100
                 ....*....|....*....|....*....
gi 762767832 261 GIERwrkFRRVMISVAGNTELRLNDVLLI 289
Cdd:COG0490  101 AIRR---GGEVILSPGPDTVLEAGDTLVV 126
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 430-608 5.93e-08

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 55.34  E-value: 5.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 430 AMMLTDEIPNAVAALIACLLMGKFRCI----DMESAYRAIHWPSIILIVGMMPFALALQQTGGVT-LIVKGLMDVAGDAG 504
Cdd:cd01116    6 ALIIFEKVHRTVAALAGALWLVILGLAtlspDLETIVSWVDWETLALLLGMMIIVSILSETGVFEyLAIWAVKISKGRPW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 505 PHVMLVCLFVlcAVIGLFISNTATAVLMAPIAIAAAKQMGVSPYPFAMIIAIAASAAFM-TPVSSPVNTLVLGPGGYKFG 583
Cdd:cd01116   86 RLLLLLGLLT--AFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAaTLIGDPPNIMIGSAAGLTFN 163

                        170       180
                 ....*....|....*....|....*
gi 762767832 584 DFVRVGVPFTVLVMLVSVVMVPWLY 608
Cdd:cd01116  164 DFLLHMLPSVVLALVVTFILLYFLY 188
CitMHS pfam03600
Citrate transporter;
14-127 1.74e-07

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 53.47  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   14 IAIVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSgeMK 93
Cdd:pfam03600 214 LVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLSGL--LV 291

                          90       100       110
                  ....*....|....*....|....*....|....
gi 762767832   94 MLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSA 127
Cdd:pfam03600 292 ALALILWLSALLSAFISNVPTAALMAPIIVGMAP 325
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
14-191 1.88e-07

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 53.59  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  14 IAIVLFTTNKLRMDVVALLVIIAFVLSGTLTLSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMK 93
Cdd:COG1055  230 VGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  94 MLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMKISPgrLMMPLSFAGLISGMMTLVATPPNMVVSSELMREGVAgF 173
Cdd:COG1055  310 AALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIK-I 386

                        170
                 ....*....|....*...
gi 762767832 174 GFFSVTPIGIVVLLLGVA 191
Cdd:COG1055  387 SFGEFLKVGLPLTLLTLL 404
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 95-384 2.39e-07

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 53.59  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  95 LILLMVTVALLGAfmsstgVVAIFIPVVLSVSarmkispgrlmMPLSfAGLISGMMTlvATP---------PNMVVSSEL 165
Cdd:COG2985   91 LNLLAVVVVVLGL------LVALALAKLFGLD-----------PGLA-AGLFAGALT--NTPalgaaqdalGKLGLSKQL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 166 MREGVAGFgffSVT-PIGIVVLLLGVAYMmvaRYWLGGAETATAKEMWK--RRTFRDLI-RDYRLTGrarrlairpgSPF 241
Cdd:COG2985  151 SANPAVGY---AVAyPFGVIGIILFVALL---PKLFRIDLDAEAKKLEAgeGSAYPPLVtRAYRVTN----------PNL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 242 IGHRLDDLRlrQRFGANVVgIERwrkFRR--VMISVAGNTELRLNDVLLIDMSASEVDlrefctaqrlEPMVLRG-EYFS 318
Cdd:COG2985  215 VGKTVAELE--ALLGTRVV-ISR---IRRggEIIVPTPDTVLQEGDIVLVVGTREALE----------AAEALLGeEVDD 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832 319 EQARDVGMAEVS-LIPDSELLGKTLYDVGFRSRYGLSVVGIRRAGEAMeGILADEPLQLGDILLVMG 384
Cdd:COG2985  279 SELLDSDLDVRRiVVTNKEVAGKTLGELNLRNRFGVVITRVRRGGVEL-PATPDTVLQLGDRLTVVG 344
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 15-163 4.31e-07

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 52.76  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   15 AIVLFTTNKLRMDVVALLVIIAF-VLSGTLT---LSEALVGFSDPNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSG 90
Cdd:pfam00939  40 TIVGWILEPLPMAVIALFAISLSaILIGTLLakaLSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKR 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   91 EMKMLILLMVTVALLGAFMSSTGV--VAIFIPVVLSVSARMKISP---------GRLMMPLSFAGLISGMMTLVATPPNM 159
Cdd:pfam00939 120 TLGLGYGLVFSDLLLAPATPSNTAraGGIVFPIIMSLPPAFGSDPekgserrigAYLMWTVYQSTSITSAMFLTAMAPNL 199


                  ....
gi 762767832  160 VVSS 163
Cdd:pfam00939 200 LLLG 203
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 28-199 4.65e-07

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 52.64  E-value: 4.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  28 VVALLVIIAFVLSGTLTLSEAL---VGFSDPNVI-LIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTVA 103
Cdd:cd01116   17 VAALAGALWLVILGLATLSPDLetiVSWVDWETLaLLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 104 LLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVVSSelmREGVAGFGFFSVTPIGI 183
Cdd:cd01116   97 FLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS---AAGLTFNDFLLHMLPSV 173

                        170
                 ....*....|....*.
gi 762767832 184 VVLLLGVAYMMVARYW 199
Cdd:cd01116  174 VLALVVTFILLYFLYR 189
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 57-199 1.00e-06

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 51.60  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   57 VILIAALFVIGEGLVRTGVAYQVGDWLVRV--AGSGEMKMLILLMVTVALLGAFMSSTGVVAIFIPVVLSVSARMK-ISP 133
Cdd:pfam00939 325 LIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPgAPP 404

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 762767832  134 GRLMMPLSFAGLISGMMTLVATPPNMVvsselmregVAGFGFFSVTP---IGIVVLLLGVAYMMVARYW 199
Cdd:pfam00939 405 LLAALLLGFAISLGGFLTPYGTGPGPI---------YFGSGYLKVKDwwrIGAILTIIGLLILLLLGNW 464
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 303-381 3.84e-06

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 48.91  E-value: 3.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 303 TAQRLEPMVLRG---EYFSEQARDVGMAEVSLIPDSELLGKTLYDVGFRSRYGLSVVGIRRAGEaMEGILADEPLQLGDI 379
Cdd:COG0569  216 AARRIARLLLRPgvlDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGE-VIIPSGDTVLEAGDE 294


                 ..
gi 762767832 380 LL 381
Cdd:COG0569  295 LI 296
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 29-157 6.00e-06

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 48.79  E-value: 6.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832   29 VALLVIIAFVLSGTLTLSEALVGFSDPN------VILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMkMLILLMVTV 102
Cdd:pfam06808 242 VVYALLIGVLVYRRLTLEEVAAALLQTAkttaavLFILAAAGIFAGLLTITGVPFKLSDWLLSLGGGNLL-FLILVNLLC 320

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 762767832  103 ALLGAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMmtlvaTPP 157
Cdd:pfam06808 321 LVLGMFLDPTAAIIILVPILAPAAAQLGIDPIHFGVVIVYNGSIGLI-----TPP 370
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 204-288 7.31e-06

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 48.14  E-value: 7.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 204 ETATAKEMWK---RRTFRDLIRDYRLTGRARRLAIRPGSPFIGHRLDDLRLRQRFGANVVGIERwrkfRRVMISVAGNTE 280
Cdd:COG0569  213 ERLAARRIARlllRPGVLDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKR----GGEVIIPSGDTV 288


                 ....*...
gi 762767832 281 LRLNDVLL 288
Cdd:COG0569  289 LEAGDELI 296
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
421-593 8.62e-05

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 45.12  E-value: 8.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 421 ALFCLALMVAMMLTDE---IPNAVAALIACLLMGKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQTGGVTLIVKGLM 497
Cdd:COG1055  221 SLLVLALLLVGFVLHSflgLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLA 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 498 DVAGDAGPHVMLVCLFVLcAVIGLFISNTATAVLMAPIAiaaaKQMGVSPYPFAMIIAIAASAAF---MTPVSSPVNTLV 574
Cdd:COG1055  301 SLTGGNLLLAALLILWLS-AILSAVVDNVPLVAALLPLI----PDLGATGNPEPLWLALALGATLggnLTPIGSAANVIV 375

                        170       180
                 ....*....|....*....|....
gi 762767832 575 LG-----PGGYKFGDFVRVGVPFT 593
Cdd:COG1055  376 LGiaekkGIKISFGEFLKVGLPLT 399
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 421-588 2.06e-04

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 44.18  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 421 ALFCLALMVAMMLTDEIPNAVAALIACLLMGKFRCIDMESAYRAIH--WPSIILIVGMMPFALALQQTGGVTLiVKGLMD 498
Cdd:cd01118    4 AIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGivWDVTLTLIGVILLSLLLDEEGFFEW-VAALAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 499 VAGDAGPHVMLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPY---PFAMIIAIAA-SAAFMTPVSSPVNTLV 574
Cdd:cd01118   83 RWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNrtlPFLYACAFIAdAASLPLPISNLVNIVT 162

                        170
                 ....*....|....
gi 762767832 575 LGPGGYKFGDFVRV 588
Cdd:cd01118  163 AGYFGIGFTEYAAL 176
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 467-593 3.29e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 43.51  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  467 WPSIILIVGMMPFALALQQTGGVTLIVKGLMDVAGDAGPHV-MLVCLFVLCAVIGLFISNTATAVLMAPIAIAAAKQMGV 545
Cdd:pfam00939 322 WNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMaFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPG 401

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 762767832  546 SPYPFAMIIAIAAS--AAFMTPVSSPVNTLVLGPGGYKFGDFVRVGVPFT 593
Cdd:pfam00939 402 APPLLAALLLGFAIslGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILT 451
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 411-591 4.32e-04

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 43.10  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  411 VAPAVSQAPHALFC-LALMVAMMLTDEIPNAVAALIACLLM----GKFRCIDMESAYRAIHWPSIILIVGMMPFALALQQ 485
Cdd:TIGR00785   2 VPDGLNSGAWLLLAiFVAAIVGWILEPLPLPVTALLAIPIIavllGVLSAFKFKNALSGFADPTIWLFFGAFILATALVK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  486 TGGVTLIVKGLMDVAGDAGPHVMLVCLFVLCAVIGLFISNTA-TAVLMAPIAIAAAKQMGVSP---------YPFAMIIA 555
Cdd:TIGR00785  82 TGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPeksprkigkYLMLGIAY 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 762767832  556 IAASAAFMTPVSSPVNTLVLG------PGGYKFGDFVRVGVP 591
Cdd:TIGR00785 162 SASIGSSGFLTGSAPNALAAGilskilGIQISWGDWFLAGLP 203
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 28-200 3.07e-03

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 40.33  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  28 VVALLVIIAFVLSGTLTLSEALVGFSD--PNVILIAALFVIGEGLVRTGVAYQVGDWLVRVAGSGEMKMLILLMVTVALL 105
Cdd:cd01118   24 VWAVLGAVIALILGLVSPHDALEVWGIvwDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 106 GAFMSSTGVVAIFIPVVLSVSARMKISPGRLMMPLSFAGLISGMMTLVATPPNMVvssELMREGVAGFGFFSVTPIGIVV 185
Cdd:cd01118  104 TAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLV---NIVTAGYFGIGFTEYAALMFLP 180

                        170
                 ....*....|....*
gi 762767832 186 LLLGVAYMMVARYWL 200
Cdd:cd01118  181 SIVSILATYVVLYLF 195
NhaC COG1757
Na+/H+ antiporter NhaC/MleN [Energy production and conversion];
419-549 4.02e-03

Na+/H+ antiporter NhaC/MleN [Energy production and conversion];


Pssm-ID: 441363 [Multi-domain]  Cd Length: 418  Bit Score: 39.93  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832 419 PHALFCLALMVAMMLTDEIPNAVAALIA---CLLMGKFRCID----MESAYRAIH--WPSII--LIVGMMpfalalqqtG 487
Cdd:COG1757   31 PILVLIVVLVVGVLLYTGLALHIGLLIGlivAALLGLRKGLSwkeiEEGIIEGIKsmLPAILilLLAGAL---------I 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 762767832 488 GVTL---IVKGLMDVAGDA-GPHVMLVCLFVLCAVIGLFI-SNTATAVLMAPIAIAAAKQMGVSPYP 549
Cdd:COG1757  102 GVWIalgTVPYLIYYGLGLlSPSLFPAAAFLLCAIISFATgTSWGTFGTLGPALMGIAAALGIPLAI 168
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 469-565 5.76e-03

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 39.55  E-value: 5.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762767832  469 SIILIVGMMPFALALQQTGgvtLIVKGLMDVAGDAGPHVMLVCLfVLCAVIGLFISNTATAVLMAPIAIAAAKQMGVSPY 548
Cdd:pfam06808 277 FILAAAGIFAGLLTITGVP---FKLSDWLLSLGGGNLLFLILVN-LLCLVLGMFLDPTAAIIILVPILAPAAAQLGIDPI 352

                          90
                  ....*....|....*..
gi 762767832  549 PFAMIIAIAASAAFMTP 565
Cdd:pfam06808 353 HFGVVIVYNGSIGLITP 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH