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Conserved domains on  [gi|763142355|ref|WP_044022024|]
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M15 family metallopeptidase [Paraburkholderia graminis]

Protein Classification

M15 family metallopeptidase( domain architecture ID 13000805)

M15 family metallopeptidase of the zinc-binding metallopeptidase family, which contains mostly carboxypeptidases and dipeptidases, is involved in bacterial cell wall biosynthesis and metabolism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 151-271 1.41e-38

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


:

Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 131.72  E-value: 1.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763142355 151 ASRDWNLLDADFRTRLLLVYKIMHEQyGYEMALLEGYRSPERQNRLAQIG-----SNVTNAAAFQSYHQYGLAADNAFLR 225
Cdd:cd14845    1 SERRIAGLHPEVRAVVKELIELAEEE-GIDFRITEGYRSPARQAALYAQGrtkpgLIVTNARGGQSYHNYGLAVDIVPLV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 763142355 226 DGKLVISEKDPWAMRGYQLYGQTAEQVGLTWGGRWK-MMDLGHVEYH 271
Cdd:cd14845   80 NGKLSTGGADPWVSKAYQKLGEIAKSLGLEWGGDWKsFKDYPHFQLR 126
 
Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 151-271 1.41e-38

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 131.72  E-value: 1.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763142355 151 ASRDWNLLDADFRTRLLLVYKIMHEQyGYEMALLEGYRSPERQNRLAQIG-----SNVTNAAAFQSYHQYGLAADNAFLR 225
Cdd:cd14845    1 SERRIAGLHPEVRAVVKELIELAEEE-GIDFRITEGYRSPARQAALYAQGrtkpgLIVTNARGGQSYHNYGLAVDIVPLV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 763142355 226 DGKLVISEKDPWAMRGYQLYGQTAEQVGLTWGGRWK-MMDLGHVEYH 271
Cdd:cd14845   80 NGKLSTGGADPWVSKAYQKLGEIAKSLGLEWGGDWKsFKDYPHFQLR 126
Peptidase_M15_4 pfam13539
D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of ...
 204-270 2.72e-13

D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of the peptidase M15 family.


Pssm-ID: 433291 [Multi-domain]  Cd Length: 67  Bit Score: 63.50  E-value: 2.72e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 763142355  204 TNAAAFQSYHQYGLAADNAFLRDGklVISEKDPWAMRGY-QLYGQTAEQVGLTWGGRWKM-MDLGHVEY 270
Cdd:pfam13539   1 TGSKTGLSNHSYGLAIDINPLVNP--YWGAVLPENGIPYaDEVVEAFEKLGFEWGGDWKSfKDYMHFEY 67
 
Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 151-271 1.41e-38

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 131.72  E-value: 1.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763142355 151 ASRDWNLLDADFRTRLLLVYKIMHEQyGYEMALLEGYRSPERQNRLAQIG-----SNVTNAAAFQSYHQYGLAADNAFLR 225
Cdd:cd14845    1 SERRIAGLHPEVRAVVKELIELAEEE-GIDFRITEGYRSPARQAALYAQGrtkpgLIVTNARGGQSYHNYGLAVDIVPLV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 763142355 226 DGKLVISEKDPWAMRGYQLYGQTAEQVGLTWGGRWK-MMDLGHVEYH 271
Cdd:cd14845   80 NGKLSTGGADPWVSKAYQKLGEIAKSLGLEWGGDWKsFKDYPHFQLR 126
Peptidase_M15_4 pfam13539
D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of ...
 204-270 2.72e-13

D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of the peptidase M15 family.


Pssm-ID: 433291 [Multi-domain]  Cd Length: 67  Bit Score: 63.50  E-value: 2.72e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 763142355  204 TNAAAFQSYHQYGLAADNAFLRDGklVISEKDPWAMRGY-QLYGQTAEQVGLTWGGRWKM-MDLGHVEY 270
Cdd:pfam13539   1 TGSKTGLSNHSYGLAIDINPLVNP--YWGAVLPENGIPYaDEVVEAFEKLGFEWGGDWKSfKDYMHFEY 67
Peptidase_M15 cd14814
Metalloproteases including zinc D-Ala-D-Ala carboxypeptidase, L-Ala-D-Glu peptidase, L, ...
 149-270 6.37e-04

Metalloproteases including zinc D-Ala-D-Ala carboxypeptidase, L-Ala-D-Glu peptidase, L,D-carboxypeptidase, bacteriophage endolysins, and related proteins; This family summarizes zinc-binding metallopeptidases which are mostly carboxypeptidases and dipeptidases, and includes zinc-dependent D-Ala-D-Ala carboxypeptidases, VanX, L-Ala-D-Glu peptidase, L,D-carboxypeptidase and bacteriophage endolysins, amongst other family members. These peptidases belong to MEROPS family M15 which are involved in bacterial cell wall biosynthesis and metabolism.


Pssm-ID: 350615 [Multi-domain]  Cd Length: 111  Bit Score: 38.58  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763142355 149 KDASRDWNLLDADFRTRlllvykimheqyGYEMALLEGYRSPERQNRLAQI---GSNVTNAAAF--QSYHQYGLAADnaf 223
Cdd:cd14814    1 PDAAEALARMIAAAGAE------------GRTLTINSGYRTYAQQLRLFAAkgkGSGGRRWAAPpgTSNHQWGLAID--- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 763142355 224 lrdgklvISEKDPWAMR-GYQLYGQTAEQVGLTWGGRWKMM----DLGHVEY 270
Cdd:cd14814   66 -------LGDGGGWRETqGYRWLKANAPRYGFDNPGGARRGgafqEPWHWEY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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