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MULTISPECIES: GntR family transcriptional regulator [Citrobacter]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-238 1.07e-57

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 183.14  E-value: 1.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   1 MKESLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQasgVNHPL 80
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPK---IEYPL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460  81 SHLEDLLLLAKNNLRVIK----KIDEIVADIELSQLIDCPPGSRWLHIASIREDAqnpDAPICWTDSYasTDYSRLRAFI 156
Cdd:COG2188   79 SRLTSFTEELRARGREPStrvlSAERVPADEEVAEALGLPPGAPVLRIERLRLAD---GEPVALETSY--LPAALFPGLL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460 157 RDDPHS-LISDLIETHYGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGRYTCSI 235
Cdd:COG2188  154 EEDLETgSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233


                 ...
gi 763399460 236 VLK 238
Cdd:COG2188  234 ELR 236
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-238 1.07e-57

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 183.14  E-value: 1.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   1 MKESLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQasgVNHPL 80
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPK---IEYPL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460  81 SHLEDLLLLAKNNLRVIK----KIDEIVADIELSQLIDCPPGSRWLHIASIREDAqnpDAPICWTDSYasTDYSRLRAFI 156
Cdd:COG2188   79 SRLTSFTEELRARGREPStrvlSAERVPADEEVAEALGLPPGAPVLRIERLRLAD---GEPVALETSY--LPAALFPGLL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460 157 RDDPHS-LISDLIETHYGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGRYTCSI 235
Cdd:COG2188  154 EEDLETgSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233


                 ...
gi 763399460 236 VLK 238
Cdd:COG2188  234 ELR 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 1.34e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.81  E-value: 1.34e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460   4 SLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVC 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 5-68 1.78e-18

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 76.50  E-value: 1.78e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 763399460    5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-68 1.03e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 71.84  E-value: 1.03e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460     9 IARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11402 PRK11402
transcriptional regulator PhoB;
5-235 9.49e-16

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 74.10  E-value: 9.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQAS----GVNHPL 80
Cdd:PRK11402  10 LYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEnallTVSGFT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460  81 SHLEDLLLLAKNnlRVIKKidEIVADIELSQLIDCPPGSRWLHIASIredAQNPDAPICWTDSYASTD-YSRLRAFIRDD 159
Cdd:PRK11402  90 DFGVSQGKATKE--KVIEQ--ERVSAAPFCEKLNIPGNSEVFHLCRV---MYLDKEPLFIDSSWIPLSrYPDFDEIYVEG 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460 160 phSLISDLIETHYGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGRYTCSI 235
Cdd:PRK11402 163 --SSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTI 236
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 4-230 8.46e-15

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 71.35  E-value: 8.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460    4 SLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV-CEPQASGVNHPLSH 82
Cdd:TIGR02325   8 ALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaARRIDYPLSARTRF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   83 LEDLLLLAKNNLRVIKKIDEIVADIELSQLIDCPPGSRWLHIASIREdAQNpdAPICWTDSY--ASTDYSRLRAFirdDP 160
Cdd:TIGR02325  88 SQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRK-ADG--RPLCRATTWfpAARFPGIGQAY---AA 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 763399460  161 HSLISDLIEtHYGIKSHEVHQT-ITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGR 230
Cdd:TIGR02325 162 SGSITDALR-EQGVADYRRSSTrISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-238 1.07e-57

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 183.14  E-value: 1.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   1 MKESLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQasgVNHPL 80
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPK---IEYPL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460  81 SHLEDLLLLAKNNLRVIK----KIDEIVADIELSQLIDCPPGSRWLHIASIREDAqnpDAPICWTDSYasTDYSRLRAFI 156
Cdd:COG2188   79 SRLTSFTEELRARGREPStrvlSAERVPADEEVAEALGLPPGAPVLRIERLRLAD---GEPVALETSY--LPAALFPGLL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460 157 RDDPHS-LISDLIETHYGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGRYTCSI 235
Cdd:COG2188  154 EEDLETgSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233


                 ...
gi 763399460 236 VLK 238
Cdd:COG2188  234 ELR 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 1.34e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.81  E-value: 1.34e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460   4 SLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVC 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
2-79 2.10e-23

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 94.23  E-value: 2.10e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 763399460   2 KESLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQASGVNHP 79
Cdd:COG2186    5 RRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 5-68 1.78e-18

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 76.50  E-value: 1.78e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 763399460    5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-68 1.03e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 71.84  E-value: 1.03e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460     9 IARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-79 2.15e-16

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 77.56  E-value: 2.15e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 763399460   1 MKESLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQASGVNHP 79
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPAP 87
PRK11402 PRK11402
transcriptional regulator PhoB;
5-235 9.49e-16

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 74.10  E-value: 9.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQAS----GVNHPL 80
Cdd:PRK11402  10 LYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEnallTVSGFT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460  81 SHLEDLLLLAKNnlRVIKKidEIVADIELSQLIDCPPGSRWLHIASIredAQNPDAPICWTDSYASTD-YSRLRAFIRDD 159
Cdd:PRK11402  90 DFGVSQGKATKE--KVIEQ--ERVSAAPFCEKLNIPGNSEVFHLCRV---MYLDKEPLFIDSSWIPLSrYPDFDEIYVEG 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460 160 phSLISDLIETHYGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGRYTCSI 235
Cdd:PRK11402 163 --SSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTI 236
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 4-230 8.46e-15

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 71.35  E-value: 8.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460    4 SLYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV-CEPQASGVNHPLSH 82
Cdd:TIGR02325   8 ALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaARRIDYPLSARTRF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   83 LEDLLLLAKNNLRVIKKIDEIVADIELSQLIDCPPGSRWLHIASIREdAQNpdAPICWTDSY--ASTDYSRLRAFirdDP 160
Cdd:TIGR02325  88 SQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRK-ADG--RPLCRATTWfpAARFPGIGQAY---AA 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 763399460  161 HSLISDLIEtHYGIKSHEVHQT-ITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGR 230
Cdd:TIGR02325 162 SGSITDALR-EQGVADYRRSSTrISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 95-232 2.81e-14

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 67.62  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   95 RVIKkIDEIVADIELSQLIDCPPGSRWLHIASIR-EDaqnpDAPICWTDSYasTDYSRLRAFIRDDP--HSLiSDLIETH 171
Cdd:pfam07702   9 EVLS-LEEVPASAEIAEALGLPPGEPVYRIERLRyAD----GEPVALEEDY--LPAELVPDLLEEDLeeGSL-YDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 763399460  172 YGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFETTISIHPAGRYT 232
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK09764 PRK09764
GntR family transcriptional regulator;
5-220 1.24e-13

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 67.93  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQASGVNHPLSHLE 84
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460  85 DLLLLAKNNLRVIKKIDEIV-ADIELSQLIDCPPGSRWLHIASIREDAQNPDA-PICWTdsyastdysrlrafirddPHS 162
Cdd:PRK09764  86 EKLSDRHVDTHSEVLIFEVIpADDFLQQQLQITAQDRVWHVKRVRYRKQKPMAlEETWM------------------PLA 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763399460 163 LISDL------------IETHYGIKSHEVHQTITAVGVPKKIAKILNVEPDSPGMRIVRRYRDRDGKVFE 220
Cdd:PRK09764 148 LFPDLtwqvmenskyhfIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFE 217
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-71 1.52e-12

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 64.56  E-value: 1.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 763399460   1 MKESLYKRIARELAHQISTGTYPPGSLFpTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEP 71
Cdd:COG1802    8 RRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
5-70 3.96e-12

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 60.96  E-value: 3.96e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCE 70
Cdd:COG1725   11 IYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
PRK14999 PRK14999
histidine utilization repressor; Provisional
 5-72 1.82e-10

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 59.18  E-value: 1.82e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQ 72
Cdd:PRK14999  13 FYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
9-70 2.01e-09

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 56.18  E-value: 2.01e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 763399460   9 IARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCE 70
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 4-68 5.67e-09

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 54.78  E-value: 5.67e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 763399460   4 SLYKRIARELAHQISTgTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:PRK10079  12 TRYQEIAAKLEQELRQ-HYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
PRK11523 PRK11523
transcriptional regulator ExuR;
5-72 6.71e-09

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 54.85  E-value: 6.71e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQ 72
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQ 76
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 5-73 1.28e-07

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 50.79  E-value: 1.28e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 763399460   5 LYKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQA 73
Cdd:PRK03837  14 LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSA 82
PRK10225 PRK10225
Uxu operon transcriptional regulator;
6-74 2.42e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 47.32  E-value: 2.42e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 763399460   6 YKRIARELAHQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQAS 74
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGS 79
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 7-68 3.22e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 47.07  E-value: 3.22e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460   7 KRIARELAHQ----ISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:PRK10421   1 RRLSDEVADRvralIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
17-68 4.00e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 40.62  E-value: 4.00e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 763399460  17 ISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:PRK04984  20 IWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 7-68 7.14e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 39.75  E-value: 7.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 763399460   7 KRIARELAHQIST----GTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRV 68
Cdd:PRK09990   6 RPIADVVAERIERlivdGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-67 2.09e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.64  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 763399460   33 ELCETWQVSRHTMREALRELTEQGLISRRKGAGTR 67
Cdd:pfam12802  24 ELARRLGISKQTVSRLVKRLEAKGLVEREPSPADR 58
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 15-75 6.09e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 37.33  E-value: 6.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 763399460  15 HQISTGTYPPGSLFPTEMELCETWQVSRHTMREALRELTEQGLISRRKGAGTRVCEPQASG 75
Cdd:PRK15481  16 QLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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