NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|764442038|ref|WP_044367342|]
View 

SGNH/GDSL hydrolase family protein [Vibrio fluvialis]

Protein Classification

SGNH/GDSL hydrolase family protein( domain architecture ID 10110895)

SGNH/GDSL hydrolase family protein is a hydrolytic enzyme such as an esterase or lipase; may have multifunctional properties including broad substrate specificity and regiospecificity

CATH:  3.40.50.1110
EC:  3.1.-.-
Gene Ontology:  GO:0016788
PubMed:  35871440|15522763
SCOP:  3001315

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
fatty_acyltransferase_like cd01846
Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and ...
 148-411 4.33e-78

Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Might catalyze fatty acid transfer between phosphatidylcholine and sterols.


:

Pssm-ID: 238882 [Multi-domain]  Cd Length: 270  Bit Score: 242.67  E-value: 4.33e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 148 KVIAFGDSLSDTGNIFNASQWRFPNPNS-WFVGHFSNGFVWTEYLAQGLGL----PLYNWAVGGAAGRNQ-----YWALT 217
Cdd:cd01846    1 RLVVFGDSLSDTGNIFKLTGGSNPPPSPpYFGGRFSNGPVWVEYLAATLGLsglkQGYNYAVGGATAGAYnvppyPPTLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 218 GVNEQVSSYLTYMemaPNYRAENTLFTLEFGLNDFMNY-------DRSLADVKADYSSALIRLVEAGAKNLVLLTLPDAT 290
Cdd:cd01846   81 GLSDQVAAFLAAH---KLRLPPDTLVAIWIGANDLLNAldlpqnpDTLVTRAVDNLFQALQRLYAAGARNFLVLNLPDLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 291 RAPQFQYSTQEHIDEVRAKVIGMNAFIREQARYFQMQ--GINISLFDAYTLFDQMIADPAAHGFDNASAPCLDIQRSSAA 368
Cdd:cd01846  158 LTPAFQAQGDAVAARATALTAAYNAKLAEKLAELKAQhpGVNILLFDTNALFNDILDNPAAYGFTNVTDPCLDYVYSYSP 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 764442038 369 DylythalaaeCASSGSDRFVFWDVTHPTTATHRYIADHILAT 411
Cdd:cd01846  238 R----------EACANPDKYLFWDEVHPTTAVHQLIAEEVAAA 270
 
Name Accession Description Interval E-value
fatty_acyltransferase_like cd01846
Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and ...
 148-411 4.33e-78

Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Might catalyze fatty acid transfer between phosphatidylcholine and sterols.


Pssm-ID: 238882 [Multi-domain]  Cd Length: 270  Bit Score: 242.67  E-value: 4.33e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 148 KVIAFGDSLSDTGNIFNASQWRFPNPNS-WFVGHFSNGFVWTEYLAQGLGL----PLYNWAVGGAAGRNQ-----YWALT 217
Cdd:cd01846    1 RLVVFGDSLSDTGNIFKLTGGSNPPPSPpYFGGRFSNGPVWVEYLAATLGLsglkQGYNYAVGGATAGAYnvppyPPTLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 218 GVNEQVSSYLTYMemaPNYRAENTLFTLEFGLNDFMNY-------DRSLADVKADYSSALIRLVEAGAKNLVLLTLPDAT 290
Cdd:cd01846   81 GLSDQVAAFLAAH---KLRLPPDTLVAIWIGANDLLNAldlpqnpDTLVTRAVDNLFQALQRLYAAGARNFLVLNLPDLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 291 RAPQFQYSTQEHIDEVRAKVIGMNAFIREQARYFQMQ--GINISLFDAYTLFDQMIADPAAHGFDNASAPCLDIQRSSAA 368
Cdd:cd01846  158 LTPAFQAQGDAVAARATALTAAYNAKLAEKLAELKAQhpGVNILLFDTNALFNDILDNPAAYGFTNVTDPCLDYVYSYSP 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 764442038 369 DylythalaaeCASSGSDRFVFWDVTHPTTATHRYIADHILAT 411
Cdd:cd01846  238 R----------EACANPDKYLFWDEVHPTTAVHQLIAEEVAAA 270
COG3240 COG3240
Phospholipase/lecithinase/hemolysin [Lipid transport and metabolism, General function ...
 140-416 7.44e-78

Phospholipase/lecithinase/hemolysin [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 442472 [Multi-domain]  Cd Length: 305  Bit Score: 243.41  E-value: 7.44e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 140 ANAPSKINKVIAFGDSLSDTGNIFNASQWRfPNPNSWFVGHFSNGFVWTEYLAQGLGLPL-------YNWAVGGAAGRNQ 212
Cdd:COG3240   22 AASAAAFSRIVVFGDSLSDTGNLFNLTGGL-PPSPPYFGGRFSNGPVWVEYLAAALGLPLtpssaggTNYAVGGARTGDG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 213 Y------WALTGVNEQVSSYLTymeMAPNYRAENTLFTLEFGLNDFMN-----------YDRSLADVKADYSSALIRLVE 275
Cdd:COG3240  101 NgvlggaALLPGLAQQVDAYLA---AAGGTADPNALYIVWAGANDLLAalaavgatpaqAQAAATAAAANLAAAVGALAA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 276 AGAKNLVLLTLPDATRAPQFQYSTQEHIDEVRAKVIGMNAFIREQARYfqmQGINISLFDAYTLFDQMIADPAAHGFDNA 355
Cdd:COG3240  178 AGARHILVPNLPDLGLTPAAQALGAAAAALLSALTAAFNQALAAALPA---LGVNIILFDVNSLFNEIIANPAAYGFTNV 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 764442038 356 SAPCLDIQRSSAAdylythalaaeCAsSGSDRFVFWDVTHPTTATHRYIADHILATGVAQF 416
Cdd:COG3240  255 TDACLSGTVSALL-----------CV-ANPDTYLFWDGVHPTTAAHRLIADYAYSALAAPG 303
Lipase_GDSL pfam00657
GDSL-like Lipase/Acylhydrolase;
149-408 4.79e-19

GDSL-like Lipase/Acylhydrolase;


Pssm-ID: 459892 [Multi-domain]  Cd Length: 210  Bit Score: 84.93  E-value: 4.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  149 VIAFGDSLSDTGNifnasqwrfpnpNSWFvGHFSNGFVWTEYLAQGLGLPL------YNWAVGGAAGRNQYwaltgvnEQ 222
Cdd:pfam00657   1 IVAFGDSLTDGGG------------DGPG-GRFSWGDLLADFLARKLGVPGsgynhgANFAIGGATIEDLP-------IQ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  223 VSSYLTYMEMAPNYRAENtLFTLEFGLNDFMNYDRSLADVKADYSSALIRLVEagaknlvlltlpdatRAPQFQYSTQEH 302
Cdd:pfam00657  61 LEQLLRLISDVKDQAKPD-LVTIFIGANDLCNFLSSPARSKKRVPDLLDELRA---------------NLPQLGLGARKF 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  303 IDeVRAKVIGMNAFIREQARYFQMQGinislfDAYTLFDQMIADPAAHgFDNASAPCLDIqrssaadYLYTHALAAECAS 382
Cdd:pfam00657 125 WV-HGLGPLGCTPPKGCYELYNALAE------EYNERLNELVNSLAAA-AEDANVVYVDI-------YGFEDPTDPCCGI 189

                         250       260
                  ....*....|....*....|....*.
gi 764442038  383 SGSdrfvfWDVTHPTTATHRYIADHI 408
Cdd:pfam00657 190 GLE-----PDGLHPSEKGYKAVAEAI 210
PRK15381 PRK15381
type III secretion system effector;
146-405 3.13e-18

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 85.87  E-value: 3.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 146 INKVIAFGDSLSDT-GNIFNASQWRFPNPNSWFVGHFSNGFVWTEYLA--QGLGLPLYNWAVGGAAGRNqYWALTGVNEQ 222
Cdd:PRK15381 142 ITRLVFFGDSLSDSlGRMFEKTHHILPSYGQYFGGRFTNGFTWTEFLSspHFLGKEMLNFAEGGSTSAS-YSCFNCIGDF 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 223 VSSylTYMEMAPNYRAENTLFTLEFGLNDFMNYDR-SLADVKADYSSALIRLVEAGAKNLVLLTLPDATRAPQFQYSTQE 301
Cdd:PRK15381 221 VSN--TDRQVASYTPSHQDLAIFLLGANDYMTLHKdNVIMVVEQQIDDIEKIISGGVNNVLVMGIPDLSLTPYGKHSDEK 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 302 HidEVRAKVIGMNAFIRE-----QARYFQMQginISLFDAYTLFDQMIADPAAHGFDNASApcldiqrssaadylYTHAL 376
Cdd:PRK15381 299 R--KLKDESIAHNALLKTnveelKEKYPQHK---ICYYETADAFKVIMEAASNIGYDTENP--------------YTHHG 359

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 764442038 377 AAECASSG------SDRFVFWDVTHPTTATHRYIA 405
Cdd:PRK15381 360 YVHVPGAKdpqldiCPQYVFNDLVHPTQEVHHCFA 394
 
Name Accession Description Interval E-value
fatty_acyltransferase_like cd01846
Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and ...
 148-411 4.33e-78

Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Might catalyze fatty acid transfer between phosphatidylcholine and sterols.


Pssm-ID: 238882 [Multi-domain]  Cd Length: 270  Bit Score: 242.67  E-value: 4.33e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 148 KVIAFGDSLSDTGNIFNASQWRFPNPNS-WFVGHFSNGFVWTEYLAQGLGL----PLYNWAVGGAAGRNQ-----YWALT 217
Cdd:cd01846    1 RLVVFGDSLSDTGNIFKLTGGSNPPPSPpYFGGRFSNGPVWVEYLAATLGLsglkQGYNYAVGGATAGAYnvppyPPTLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 218 GVNEQVSSYLTYMemaPNYRAENTLFTLEFGLNDFMNY-------DRSLADVKADYSSALIRLVEAGAKNLVLLTLPDAT 290
Cdd:cd01846   81 GLSDQVAAFLAAH---KLRLPPDTLVAIWIGANDLLNAldlpqnpDTLVTRAVDNLFQALQRLYAAGARNFLVLNLPDLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 291 RAPQFQYSTQEHIDEVRAKVIGMNAFIREQARYFQMQ--GINISLFDAYTLFDQMIADPAAHGFDNASAPCLDIQRSSAA 368
Cdd:cd01846  158 LTPAFQAQGDAVAARATALTAAYNAKLAEKLAELKAQhpGVNILLFDTNALFNDILDNPAAYGFTNVTDPCLDYVYSYSP 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 764442038 369 DylythalaaeCASSGSDRFVFWDVTHPTTATHRYIADHILAT 411
Cdd:cd01846  238 R----------EACANPDKYLFWDEVHPTTAVHQLIAEEVAAA 270
COG3240 COG3240
Phospholipase/lecithinase/hemolysin [Lipid transport and metabolism, General function ...
 140-416 7.44e-78

Phospholipase/lecithinase/hemolysin [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 442472 [Multi-domain]  Cd Length: 305  Bit Score: 243.41  E-value: 7.44e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 140 ANAPSKINKVIAFGDSLSDTGNIFNASQWRfPNPNSWFVGHFSNGFVWTEYLAQGLGLPL-------YNWAVGGAAGRNQ 212
Cdd:COG3240   22 AASAAAFSRIVVFGDSLSDTGNLFNLTGGL-PPSPPYFGGRFSNGPVWVEYLAAALGLPLtpssaggTNYAVGGARTGDG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 213 Y------WALTGVNEQVSSYLTymeMAPNYRAENTLFTLEFGLNDFMN-----------YDRSLADVKADYSSALIRLVE 275
Cdd:COG3240  101 NgvlggaALLPGLAQQVDAYLA---AAGGTADPNALYIVWAGANDLLAalaavgatpaqAQAAATAAAANLAAAVGALAA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 276 AGAKNLVLLTLPDATRAPQFQYSTQEHIDEVRAKVIGMNAFIREQARYfqmQGINISLFDAYTLFDQMIADPAAHGFDNA 355
Cdd:COG3240  178 AGARHILVPNLPDLGLTPAAQALGAAAAALLSALTAAFNQALAAALPA---LGVNIILFDVNSLFNEIIANPAAYGFTNV 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 764442038 356 SAPCLDIQRSSAAdylythalaaeCAsSGSDRFVFWDVTHPTTATHRYIADHILATGVAQF 416
Cdd:COG3240  255 TDACLSGTVSALL-----------CV-ANPDTYLFWDGVHPTTAAHRLIADYAYSALAAPG 303
SGNH_plant_lipase_like cd01837
SGNH_plant_lipase_like, a plant specific subfamily of the SGNH-family of hydrolases, a diverse ...
 149-409 3.46e-27

SGNH_plant_lipase_like, a plant specific subfamily of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.


Pssm-ID: 238875 [Multi-domain]  Cd Length: 315  Bit Score: 110.40  E-value: 3.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 149 VIAFGDSLSDTGNI----FNASQWRFPN-------PNswfvGHFSNGFVWTEYLAQGLGLPLY----------------- 200
Cdd:cd01837    3 LFVFGDSLVDTGNNnylpTLAKANFPPYgidfpgrPT----GRFSNGRLIIDFIAEALGLPLLpppylspngssdfltgv 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 201 NWAVGGAAGRNQYWALTGV---NEQVSSYLTYME--------MAPNYRAENTLFTLEFGLNDFMNY-----------DRS 258
Cdd:cd01837   79 NFASGGAGILDSTGFLGSVislSVQLEYFKEYKErlralvgeEAAADILSKSLFLISIGSNDYLNNyfanptrqyevEAY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 259 LADVKADYSSALIRLVEAGAKNLVLLTLPD-----ATRApQFQYSTQEHIDEV-----------RAKVIGMNAfireqar 322
Cdd:cd01837  159 VPFLVSNISSAIKRLYDLGARKFVVPGLGPlgclpSQRT-LFGGDGGGCLEELnelarlfnaklKKLLAELRR------- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 323 yfQMQGINISLFDAYTLFDQMIADPAAHGFDNASAPCldiqrsSAADYLYTHALAAECAS---SGSDRFVFWDVTHPTTA 399
Cdd:cd01837  231 --ELPGAKFVYADIYNALLDLIQNPAKYGFENTLKAC------CGTGGPEGGLLCNPCGStvcPDPSKYVFWDGVHPTEA 302

                        330
                 ....*....|
gi 764442038 400 THRYIADHIL 409
Cdd:cd01837  303 ANRIIADALL 312
Triacylglycerol_lipase_like cd01847
Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and ...
 149-410 1.88e-25

Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Members of this subfamily might hydrolyze triacylglycerol into diacylglycerol and fatty acid anions.


Pssm-ID: 238883  Cd Length: 281  Bit Score: 104.82  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 149 VIAFGDSLSDTGNIFNASQwrfPNPNSwfvGHFSN--GFVWTEYLAQGLGLPLY----------NWAVGGAA-----GRN 211
Cdd:cd01847    4 VVVFGDSLSDVGTYNRAGV---GAAGG---GRFTVndGSIWSLGVAEGYGLTTGtatpttpggtNYAQGGARvgdtnNGN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 212 QYWALT-GVNEQVSSYLTymemAPNYRAENTLFTLEFGLND--------------FMNYDRSLADVKADYSSALIRLVEA 276
Cdd:cd01847   78 GAGAVLpSVTTQIANYLA----AGGGFDPNALYTVWIGGNDliaalaalttatttQAAAVAAAATAAADLASQVKNLLDA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 277 GAKNLVLLTLPDATRAPQFQYSTQEHIDEVRAKVIGMNAFIREQARyfQMQGINISLFDAYTLFDQMIADPAAHGFDNAS 356
Cdd:cd01847  154 GARYILVPNLPDVSYTPEAAGTPAAAAALASALSQTYNQTLQSGLN--QLGANNIIYVDTATLLKEVVANPAAYGFTNTT 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 764442038 357 APCLDiqrSSAADYLYTHALAAECASSgsdRFVFWDVTHPTTATHRYIADHILA 410
Cdd:cd01847  232 TPACT---STSAAGSGAATLVTAAAQS---TYLFADDVHPTPAGHKLIAQYALS 279
Lipase_GDSL pfam00657
GDSL-like Lipase/Acylhydrolase;
149-408 4.79e-19

GDSL-like Lipase/Acylhydrolase;


Pssm-ID: 459892 [Multi-domain]  Cd Length: 210  Bit Score: 84.93  E-value: 4.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  149 VIAFGDSLSDTGNifnasqwrfpnpNSWFvGHFSNGFVWTEYLAQGLGLPL------YNWAVGGAAGRNQYwaltgvnEQ 222
Cdd:pfam00657   1 IVAFGDSLTDGGG------------DGPG-GRFSWGDLLADFLARKLGVPGsgynhgANFAIGGATIEDLP-------IQ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  223 VSSYLTYMEMAPNYRAENtLFTLEFGLNDFMNYDRSLADVKADYSSALIRLVEagaknlvlltlpdatRAPQFQYSTQEH 302
Cdd:pfam00657  61 LEQLLRLISDVKDQAKPD-LVTIFIGANDLCNFLSSPARSKKRVPDLLDELRA---------------NLPQLGLGARKF 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  303 IDeVRAKVIGMNAFIREQARYFQMQGinislfDAYTLFDQMIADPAAHgFDNASAPCLDIqrssaadYLYTHALAAECAS 382
Cdd:pfam00657 125 WV-HGLGPLGCTPPKGCYELYNALAE------EYNERLNELVNSLAAA-AEDANVVYVDI-------YGFEDPTDPCCGI 189

                         250       260
                  ....*....|....*....|....*.
gi 764442038  383 SGSdrfvfWDVTHPTTATHRYIADHI 408
Cdd:pfam00657 190 GLE-----PDGLHPSEKGYKAVAEAI 210
PRK15381 PRK15381
type III secretion system effector;
146-405 3.13e-18

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 85.87  E-value: 3.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 146 INKVIAFGDSLSDT-GNIFNASQWRFPNPNSWFVGHFSNGFVWTEYLA--QGLGLPLYNWAVGGAAGRNqYWALTGVNEQ 222
Cdd:PRK15381 142 ITRLVFFGDSLSDSlGRMFEKTHHILPSYGQYFGGRFTNGFTWTEFLSspHFLGKEMLNFAEGGSTSAS-YSCFNCIGDF 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 223 VSSylTYMEMAPNYRAENTLFTLEFGLNDFMNYDR-SLADVKADYSSALIRLVEAGAKNLVLLTLPDATRAPQFQYSTQE 301
Cdd:PRK15381 221 VSN--TDRQVASYTPSHQDLAIFLLGANDYMTLHKdNVIMVVEQQIDDIEKIISGGVNNVLVMGIPDLSLTPYGKHSDEK 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 302 HidEVRAKVIGMNAFIRE-----QARYFQMQginISLFDAYTLFDQMIADPAAHGFDNASApcldiqrssaadylYTHAL 376
Cdd:PRK15381 299 R--KLKDESIAHNALLKTnveelKEKYPQHK---ICYYETADAFKVIMEAASNIGYDTENP--------------YTHHG 359

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 764442038 377 AAECASSG------SDRFVFWDVTHPTTATHRYIA 405
Cdd:PRK15381 360 YVHVPGAKdpqldiCPQYVFNDLVHPTQEVHHCFA 394
PLN03156 PLN03156
GDSL esterase/lipase; Provisional
 139-416 4.63e-16

GDSL esterase/lipase; Provisional


Pssm-ID: 178701  Cd Length: 351  Bit Score: 79.02  E-value: 4.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 139 VANAPSKINKVIAFGDSLSDTGN---IFNASQWRFPNPNSWFV-----GHFSNGFVWTEYLAQGLGL---------PLYN 201
Cdd:PLN03156  20 VAETCAKVPAIIVFGDSSVDAGNnnqISTVAKSNFEPYGRDFPggrptGRFCNGRIAPDFISEAFGLkpaipayldPSYN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 202 ---WAVG---GAAGrnqywalTGVNEQVSSYLT----------YMEMAPNYRA-----------ENTLFTLEFGLNDFM- 253
Cdd:PLN03156 100 isdFATGvcfASAG-------TGYDNATSDVLSviplwkeleyYKEYQTKLRAylgeekaneiiSEALYLISIGTNDFLe 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 254 NY----DRS-----------LADVKADYSSALIRLveaGAKNLVLLTLPDA-----TRAPQFQYST---QEHIDEVRAKV 310
Cdd:PLN03156 173 NYytfpGRRsqytvsqyqdfLIGIAENFVKKLYRL---GARKISLGGLPPMgclplERTTNLMGGSecvEEYNDVALEFN 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 311 IGMNAFIREQARyfQMQGINISLFDAYTLFDQMIADPAAHGFDNASAPC-----LDIQRSSAADYLYThalaaeCasSGS 385
Cdd:PLN03156 250 GKLEKLVTKLNK--ELPGIKLVFSNPYDIFMQIIRNPSAYGFEVTSVACcatgmFEMGYLCNRNNPFT------C--SDA 319

                        330       340       350
                 ....*....|....*....|....*....|.
gi 764442038 386 DRFVFWDVTHPTTATHRYIADHILATGVAQF 416
Cdd:PLN03156 320 DKYVFWDSFHPTEKTNQIIANHVVKTLLSKF 350
TesA COG2755
Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK [Cell cycle ...
 142-411 4.90e-06

Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK [Cell cycle control, cell division, chromosome partitioning, Lipid transport and metabolism];


Pssm-ID: 442045 [Multi-domain]  Cd Length: 191  Bit Score: 46.95  E-value: 4.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 142 APSKINKVIAFGDSLSD-TGNifnasqwrfpnpnswfvghfSNGFVWTEYLAQGLG---LPLYNWAVGGaagrnqywalt 217
Cdd:COG2755    4 AAGKPLRIVALGDSITAgYGA--------------------SRERGWPALLARRLAaadVRVVNAGISG----------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 218 gvnEQVSSYLTYME-MAPNYRAenTLFTLEFGLNDFM-NYDRSLADVKADYSSALIRLVEAGAKNLVLLTLPDATRAPqf 295
Cdd:COG2755   53 ---ATTADLLARLDrDLLALKP--DLVVIELGTNDLLrGLGVSPEEFRANLEALIDRLRAAGPGARVVLVTPPPRLRP-- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 296 qystqehiDEVRAKVIGMNAFIREQARYFqmqgiNISLFDAYTLFDQMIADPAAHGFDNasapcldiqrssaadylytha 375
Cdd:COG2755  126 --------NYLNERIEAYNAAIRELAAEY-----GVPLVDLYAALRDAGDLPDLLTADG--------------------- 171

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 764442038 376 laaecassgsdrfvfwdvTHPTTATHRYIADHILAT 411
Cdd:COG2755  172 ------------------LHPNAAGYRLIAEAVLPA 189
Lipase_GDSL_2 pfam13472
GDSL-like Lipase/Acylhydrolase family; This family of presumed lipases and related enzymes are ...
 151-353 3.41e-04

GDSL-like Lipase/Acylhydrolase family; This family of presumed lipases and related enzymes are similar to pfam00657.


Pssm-ID: 463889  Cd Length: 176  Bit Score: 41.38  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  151 AFGDSLSDtGNIFNASQWRFPNpnswfvghfsngfVWTEYLAQGLGLPLYNW-AVGGAAGRNQYwaltgvneqvssyLTY 229
Cdd:pfam13472   1 ALGDSITA-GYGATGGDRSYPG-------------WLARLLARRLGADVVNNlGISGATTRLDL-------------LER 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038  230 MEMAPNYRAenTLFTLEFGLNDfMNYDRSLADVKADYsSALIRLVEA---GAKNLVLLTLPDATRAPQFQYSTQEHIDEV 306
Cdd:pfam13472  54 LDDVLRLKP--DLVVILLGTND-LGRGVSAARAAANL-EALIDALRAagpDARVLLIGPLPVGPPPPLDERRLNARIAEY 129

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 764442038  307 rakvigmNAFIREQARYFqmqgiNISLFDAYTLFDQMIADPAAHGFD 353
Cdd:pfam13472 130 -------NAAIREVAAER-----GVPYVDLWDALRDDGGWLPDLLAD 164
SGNH_hydrolase_like_1 cd01832
Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The ...
 241-322 9.71e-04

Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.


Pssm-ID: 238870  Cd Length: 185  Bit Score: 39.94  E-value: 9.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 241 TLFTLEFGLNDFMNYDRSLADVKADYSSALIRLVEAGAKnLVLLTLPD-ATRAPQFQystqehidEVRAKVIGMNAFIRE 319
Cdd:cd01832   69 DLVTLLAGGNDILRPGTDPDTYRADLEEAVRRLRAAGAR-VVVFTIPDpAVLEPFRR--------RVRARLAAYNAVIRA 139


                 ...
gi 764442038 320 QAR 322
Cdd:cd01832  140 VAA 142
SGNH_hydrolase cd00229
SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary ...
 149-310 8.47e-03

SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.


Pssm-ID: 238141 [Multi-domain]  Cd Length: 187  Bit Score: 37.39  E-value: 8.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 149 VIAFGDSLSDtgnifnasqwrfpNPNSWFVGHFSNGFVWTEYLAQGLGLPLYNWAVGGAAGRNQYWALtGVNEQVSSYlt 228
Cdd:cd00229    1 ILVIGDSITA-------------GYGASSGSTFYSLLLYLLLLAGGPGVEVINLGVSGATTADALRRL-GLRLALLKD-- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764442038 229 ymemAPNyraentLFTLEFGLNDFM-NYDRSLADVKADYSSAL--IRLVEAGAKnLVLLTLPDATRAPQFQYSTQEHIDE 305
Cdd:cd00229   65 ----KPD------LVIIELGTNDLGrGGDTSIDEFKANLEELLdaLRERAPGAK-VILITPPPPPPREGLLGRALPRYNE 133


                 ....*
gi 764442038 306 VRAKV 310
Cdd:cd00229  134 AIKAV 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH