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Conserved domains on  [gi|764533498|ref|WP_044409812|]
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MULTISPECIES: response regulator transcription factor [Pseudomonadaceae]

Protein Classification

response regulator transcription factor( domain architecture ID 11468282)

response regulator transcription factor with a receiver domain and a helix-turn-helix DNA-binding domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 10-186 5.67e-90

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 260.62  E-value: 5.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  10 EEQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVI 89
Cdd:COG4567    2 AEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  90 LTGYSSIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVEsLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALG 169
Cdd:COG4567   82 LTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAP-APPENPMSLDRLEWEHIQRVLAECDGNISATARALG 160

                        170
                 ....*....|....*..
gi 764533498 170 MHRRTLQRKLQKRPVRR 186
Cdd:COG4567  161 MHRRTLQRKLAKRPPRR 177
 
Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 10-186 5.67e-90

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 260.62  E-value: 5.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  10 EEQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVI 89
Cdd:COG4567    2 AEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  90 LTGYSSIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVEsLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALG 169
Cdd:COG4567   82 LTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAP-APPENPMSLDRLEWEHIQRVLAECDGNISATARALG 160

                        170
                 ....*....|....*..
gi 764533498 170 MHRRTLQRKLQKRPVRR 186
Cdd:COG4567  161 MHRRTLQRKLAKRPPRR 177
ActR_PrrA_rreg NF033791
ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are ...
 15-182 3.21e-67

ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are examples of lineage-specific names given to a response regulator transcription factor that acts as a global regulator and belongs to a sensor-regulator pair that is highly conserved in the alpha-proteobacteria. Examples of this regulator include ActR (acid tolerance regulator) in Sinorhizobium meliloti, stationary phase response regulator SpdR in Caulobacter crescentus,


Pssm-ID: 411371 [Multi-domain]  Cd Length: 173  Bit Score: 202.83  E-value: 3.21e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:NF033791   4 LLIVDDDKPFLQRLARAMEKRGFEVTTAESVAEGLAAAKAAPPAFAVVDLRLGDGNGLDVVEALRERRPDARIVVLTGYG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTALLsQQADVESLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALGMHRRT 174
Cdd:NF033791  84 NIATAVAAVKLGAVDYLAKPADADDVEAALL-ARPGEKPEPPENPMSADRVRWEHIQRVYELCDRNVSETARRLNMHRRT 162


                 ....*...
gi 764533498 175 LQRKLQKR 182
Cdd:NF033791 163 LQRILAKR 170
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 13-124 1.65e-55

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 171.09  E-value: 1.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 764533498  93 YSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17563   81 YASIATAVEAIKLGADDYLAKPADADEILAAL 112
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 16-124 3.02e-18

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 76.04  E-value: 3.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498   16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGD 81

                          90       100
                  ....*....|....*....|....*....
gi 764533498   96 IATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:pfam00072  82 EDDAVEALEAGADDFLSKPFDPDELLAAI 110
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
15-150 1.19e-16

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 76.81  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVltALLSQQA-DVESLVPEN-----PMSvDRLQWEHI 150
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIKPFDLDEL--NLIVQRAlQLQSMKKEIrhlhqALS-TSWQWGHI 145
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 13-66 9.78e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 46.79  E-value: 9.78e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 764533498    13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKM 66
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
 
Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 10-186 5.67e-90

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 260.62  E-value: 5.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  10 EEQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVI 89
Cdd:COG4567    2 AEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  90 LTGYSSIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVEsLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALG 169
Cdd:COG4567   82 LTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAP-APPENPMSLDRLEWEHIQRVLAECDGNISATARALG 160

                        170
                 ....*....|....*..
gi 764533498 170 MHRRTLQRKLQKRPVRR 186
Cdd:COG4567  161 MHRRTLQRKLAKRPPRR 177
ActR_PrrA_rreg NF033791
ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are ...
 15-182 3.21e-67

ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are examples of lineage-specific names given to a response regulator transcription factor that acts as a global regulator and belongs to a sensor-regulator pair that is highly conserved in the alpha-proteobacteria. Examples of this regulator include ActR (acid tolerance regulator) in Sinorhizobium meliloti, stationary phase response regulator SpdR in Caulobacter crescentus,


Pssm-ID: 411371 [Multi-domain]  Cd Length: 173  Bit Score: 202.83  E-value: 3.21e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:NF033791   4 LLIVDDDKPFLQRLARAMEKRGFEVTTAESVAEGLAAAKAAPPAFAVVDLRLGDGNGLDVVEALRERRPDARIVVLTGYG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTALLsQQADVESLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALGMHRRT 174
Cdd:NF033791  84 NIATAVAAVKLGAVDYLAKPADADDVEAALL-ARPGEKPEPPENPMSADRVRWEHIQRVYELCDRNVSETARRLNMHRRT 162


                 ....*...
gi 764533498 175 LQRKLQKR 182
Cdd:NF033791 163 LQRILAKR 170
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 13-124 1.65e-55

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 171.09  E-value: 1.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 764533498  93 YSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17563   81 YASIATAVEAIKLGADDYLAKPADADEILAAL 112
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 11-124 3.31e-28

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 108.51  E-value: 3.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  11 EQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVIL 90
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 764533498  91 TGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAV 114
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 16-114 7.97e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 79.58  E-value: 7.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 764533498  96 IATAVEAIKRGATNYLCKP 114
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 17-124 4.62e-19

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 80.14  E-value: 4.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  17 LVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSSI 96
Cdd:COG4566    4 IVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHGDV 83

                         90       100
                 ....*....|....*....|....*...
gi 764533498  97 ATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG4566   84 PMAVRAMKAGAVDFLEKPFDDQALLDAV 111
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 16-124 3.02e-18

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 76.04  E-value: 3.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498   16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGD 81

                          90       100
                  ....*....|....*....|....*....
gi 764533498   96 IATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:pfam00072  82 EDDAVEALEAGADDFLSKPFDPDELLAAI 110
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 15-124 4.45e-18

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 75.61  E-value: 4.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17550   81 TIETAVKATKLGAYDFIEKPLSLDRLLLTI 110
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 15-114 1.54e-17

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 73.65  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRG--LRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAgfEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILSG 81

                         90       100
                 ....*....|....*....|..
gi 764533498  93 YSSIATAVEAIKRGATNYLCKP 114
Cdd:COG4753   82 YSDFEYAQEAIKLGADDYLLKP 103
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 16-138 1.60e-17

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 74.45  E-value: 1.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:cd17549    2 LLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHGD 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 764533498  96 IATAVEAIKRGATNYLCKPADADDvLTALLSQQADVESLVPEN 138
Cdd:cd17549   82 VPMAVEAMRAGAYDFLEKPFDPER-LLDVVRRALEKRRLVLEN 123
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 12-124 1.70e-17

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 76.53  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  12 QPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILT 91
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  92 GYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARI 113
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 13-124 2.61e-17

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 74.12  E-value: 2.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPK--LLELDPDMRVVIL 90
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRirALPRLPDIPIIAL 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 764533498  91 TGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG0784   86 TAYADEEDRERALEAGADDYLTKPVDPEELLEAL 119
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 10-124 2.72e-17

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 76.36  E-value: 2.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  10 EEQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLV--LLPKLLELDPDMRV 87
Cdd:COG3437    4 GQAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFEllRLLRADPSTRDIPV 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 764533498  88 VILTGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG3437   84 IFLTALADPEDRERALEAGADDYLTKPFDPEELLARV 120
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 16-124 2.81e-17

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 73.70  E-value: 2.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRR-GLR-VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGY 93
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEpDIEvVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAI 112
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
15-150 1.19e-16

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 76.81  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVltALLSQQA-DVESLVPEN-----PMSvDRLQWEHI 150
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIKPFDLDEL--NLIVQRAlQLQSMKKEIrhlhqALS-TSWQWGHI 145
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 12-124 3.61e-16

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 72.25  E-value: 3.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  12 QPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPK--LLELDPDMRVVI 89
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRlrADPRTADIPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 764533498  90 LTGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
PRK15115 PRK15115
response regulator GlrR; Provisional
 14-124 1.38e-15

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 73.72  E-value: 1.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGY 93
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAH 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:PRK15115  87 GSIPDAVAATQQGVFSFLTKPVDRDALYKAI 117
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 16-134 1.83e-15

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 69.61  E-value: 1.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGL--RVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGY 93
Cdd:COG4565    7 LIVEDDPMVAELLRRYLERLPGfeVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVITAA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVESL 134
Cdd:COG4565   87 RDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLL 127
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 17-121 2.93e-15

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 68.45  E-value: 2.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  17 LVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSSI 96
Cdd:cd19919    5 IVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDL 84

                         90       100
                 ....*....|....*....|....*
gi 764533498  97 ATAVEAIKRGATNYLCKPADADDVL 121
Cdd:cd19919   85 DSAVSAYQGGAFEYLPKPFDIDEAV 109
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 15-118 3.14e-15

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 68.38  E-value: 3.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                         90       100
                 ....*....|....*....|....
gi 764533498  95 SIATAVEAIKRGATNYLCKPADAD 118
Cdd:cd17572   81 SVDIAVEAMRLGAYDFLEKPFDAD 104
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 15-124 1.84e-14

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 66.21  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSAD---EGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILT 91
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAEngeEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  92 GYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEAL 113
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
15-147 3.07e-14

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 69.67  E-value: 3.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVESLVPENPmSVDRLQW 147
Cdd:PRK10365  88 SVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETP-AVTASQF 139
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 13-124 3.69e-14

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 65.50  E-value: 3.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILLTG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  93 YSSIATAVEAIKRGAT-NYLCKPADADDVLTAL 124
Cdd:cd17569   81 YADLDAAIEAINEGEIyRFLTKPWDDEELKETI 113
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 13-127 6.67e-14

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 64.54  E-value: 6.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17537    1 ATVYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 764533498  93 YSSIATAVEAIKRGATNYLCKPADaDDVLTALLSQ 127
Cdd:cd17537   81 HGDVPMAVEAMKAGAVDFLEKPFR-DQVLLDAIEQ 114
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 13-114 2.90e-13

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 62.99  E-value: 2.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSG 80

                         90       100
                 ....*....|....*....|..
gi 764533498  93 YSSIATAVEAIKRGATNYLCKP 114
Cdd:cd17555   81 AGVMSDAVEALRLGAWDYLTKP 102
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 17-122 1.13e-12

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 65.28  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  17 LVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSSI 96
Cdd:PRK10923   8 VVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDL 87

                         90       100
                 ....*....|....*....|....*.
gi 764533498  97 ATAVEAIKRGATNYLCKPADADDVLT 122
Cdd:PRK10923  88 DAAVSAYQQGAFDYLPKPFDIDEAVA 113
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 17-124 1.65e-11

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 58.44  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  17 LVDDDATFTRVMARAM-SRRGLR-VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17542    4 LIVDDAAFMRMMLKDIlTKAGYEvVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAMG 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17542   84 QEEMVKEAIKAGAKDFIVKPFQPERVLEAV 113
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 13-95 9.90e-11

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 56.46  E-value: 9.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17554    1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80


                 ...
gi 764533498  93 YSS 95
Cdd:cd17554   81 YSE 83
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 16-114 1.24e-10

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 55.49  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                         90
                 ....*....|....*....
gi 764533498  96 IATAVEAIKRGATNYLCKP 114
Cdd:cd17574   81 EEDKVLGLELGADDYITKP 99
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 15-114 1.49e-10

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 55.59  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQN 80

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd19928   81 TLMTAVKAAERGAFEYLPKP 100
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 15-127 1.55e-10

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 56.02  E-value: 1.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTALLSQ 127
Cdd:cd17553   83 ELDMIQESKELGALTHFAKPFDIDEIRDAVKKY 115
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 116-181 2.27e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 58.63  E-value: 2.27e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 764533498 116 DADDvLTALLSQQADVESLVPENPM--SVDRLQWEHIQRVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:COG3829  378 TPEH-LPEYLLEEAEAASAAEEGSLkeALEEVEKELIEEALEKTGGNKSKAAKALGISRSTLYRKLKK 444
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 15-125 6.44e-10

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 6.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDdatftrvmaRAMSRRGLR-----------VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDP 83
Cdd:cd19931    1 VLLIDD---------HPLLRKGIKqlieldpdftvVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGV 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 764533498  84 DMRVVILTGYSSIATAVEAIKRGATNYLCKPADADDVLTALL 125
Cdd:cd19931   72 SARIVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALK 113
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 130-181 1.16e-09

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 56.39  E-value: 1.16e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 764533498 130 DVESLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:COG3604  283 DADDLAPGSREALEEVEREHILEALERTGGNIAGAARLLGLTPSTLRSRMKK 334
HTH_8 pfam02954
Bacterial regulatory protein, Fis family;
148-181 2.36e-09

Bacterial regulatory protein, Fis family;


Pssm-ID: 427077 [Multi-domain]  Cd Length: 40  Bit Score: 50.47  E-value: 2.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 764533498  148 EHIQRVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:pfam02954   7 ELIEAALERTGGNKSKAARLLGISRRTLYRKLKK 40
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 10-129 2.41e-09

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 54.65  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  10 EEQPHLLLVDDdatftrvmaRAMSRRGLR-----------VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKL 78
Cdd:PRK10651   4 QEPATILLIDD---------HPMLRTGVKqlismapditvVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKL 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 764533498  79 LELDPDMRVVILTGYSSIATAVEAIKRGATNYLCKPADADDVLTALlsQQA 129
Cdd:PRK10651  75 REKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKAL--QQA 123
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 15-114 4.57e-09

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 51.90  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARD 80

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKP 100
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 16-124 4.77e-09

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 53.42  E-value: 4.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRV-SVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLElDPDMRVVILTGYS 94
Cdd:COG3707    7 LVVDDEPLRRADLREGLREAGYEVvAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISE-ERPAPVILLTAYS 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG3707   86 DPELIERALEAGVSAYLVKPLDPEDLLPAL 115
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 139-181 5.03e-09

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 54.58  E-value: 5.03e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 764533498 139 PMSVDRLQWEHIQRVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:COG2204  374 PEALEEVERELIERALEETGGNVSRAAELLGISRRTLYRKLKK 416
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 15-114 6.38e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 51.61  E-value: 6.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd17627   81 SVSDRVAGLDAGADDYLVKP 100
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 16-124 1.11e-08

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 50.92  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDP--DMRVVILTGY 93
Cdd:cd17580    2 LVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWlaNTPAIALTGY 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17580   82 GQPEDRERALEAGFDAHLVKPVDPDELIELI 112
AcoR COG3284
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];
123-181 2.39e-08

Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];


Pssm-ID: 442514 [Multi-domain]  Cd Length: 625  Bit Score: 52.60  E-value: 2.39e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 764533498 123 ALLSQQADVESLVPENPMSVDRLQWEHIQRVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:COG3284  565 ELRAELAAAAPAAAAPLTSLEEAERDAILRALRACGGNVSAAARALGISRSTLYRKLKR 623
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 15-114 5.70e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 48.89  E-value: 5.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAKD 81

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd17615   82 SVEDRIAGLTAGGDDYVTKP 101
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 14-114 6.95e-08

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 48.26  E-value: 6.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMR---VVIL 90
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDG-FEVCRRLKEDPETRhipVIMI 79

                         90       100
                 ....*....|....*....|....
gi 764533498  91 TGYSSIATAVEAIKRGATNYLCKP 114
Cdd:cd17538   80 TALDDREDRIRGLEAGADDFLSKP 103
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 15-124 9.27e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 48.23  E-value: 9.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPK---LLELDPDMRVVILT 91
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRireLEGGGRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  92 GYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17546   81 ANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 13-66 9.78e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 46.79  E-value: 9.78e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 764533498    13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKM 66
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 16-121 1.62e-07

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 47.60  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDA 80

                         90       100
                 ....*....|....*....|....*.
gi 764533498  96 IATAVEAIKRGATNYLCKPADADDVL 121
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAELL 106
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 16-124 3.13e-07

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 48.66  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSR-RGLR-VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGY 93
Cdd:COG3279    5 LIVDDEPLARERLERLLEKyPDLEvVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTTAY 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 764533498  94 SSiaTAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:COG3279   85 DE--YALEAFEVNAVDYLLKPIDEERLAKAL 113
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 15-114 3.25e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 46.74  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMR---VVILT 91
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDG-FEVCRRLKADPATRhipVIFLT 79

                         90       100
                 ....*....|....*....|...
gi 764533498  92 GYSSIATAVEAIKRGATNYLCKP 114
Cdd:cd19920   80 ALTDTEDKVKGFELGAVDYITKP 102
PRK05022 PRK05022
nitric oxide reductase transcriptional regulator NorR;
141-182 1.07e-06

nitric oxide reductase transcriptional regulator NorR;


Pssm-ID: 235331 [Multi-domain]  Cd Length: 509  Bit Score: 47.86  E-value: 1.07e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 764533498 141 SVDRLQWEHIQRVLAEHDGNISATARALGMHRRTLQRkLQKR 182
Cdd:PRK05022 464 ATEAFQRQLIRQALAQHQGNWAAAARALELDRANLHR-LAKR 504
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 16-114 1.47e-06

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 44.84  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSS 95
Cdd:cd19926    2 LVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYGS 81

                         90
                 ....*....|....*....
gi 764533498  96 IATAVEAIKRGATNYLCKP 114
Cdd:cd19926   82 LDTAIEALKAGAFDFLTKP 100
fixJ PRK09390
response regulator FixJ; Provisional
 11-125 1.49e-06

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 46.53  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  11 EQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVIL 90
Cdd:PRK09390   2 DKGVVHVVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVM 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 764533498  91 TGYSSIATAVEAIKRGATNYLCKPADaDDVLTALL 125
Cdd:PRK09390  82 TGHGDVPLAVEAMKLGAVDFIEKPFE-DERLIGAI 115
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 13-114 1.84e-06

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 44.93  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMR---VVI 89
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSG-IQFIRRLKRDEMTRdipIIM 79

                         90       100
                 ....*....|....*....|....*
gi 764533498  90 LTGYSSIATAVEAIKRGATNYLCKP 114
Cdd:cd17618   80 LTARGEEEDKVRGLEAGADDYITKP 104
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 15-116 3.15e-06

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 44.22  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNG-LDVLKELRKTSQVPVLMLTARG 79

                         90       100
                 ....*....|....*....|..
gi 764533498  95 SIATAVEAIKRGATNYLCKPAD 116
Cdd:cd17623   80 DDIDRILGLELGADDYLPKPFN 101
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 15-121 3.67e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 44.01  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                         90       100
                 ....*....|....*....|....*..
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVL 121
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEELL 107
PRK15369 PRK15369
two component system response regulator;
38-180 4.40e-06

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 45.07  E-value: 4.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  38 RVSVAGSADEGLA---LAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSSIATAVEAIKRGATNYLCKP 114
Cdd:PRK15369  28 RYKIVGQVDNGLEvynACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLTARQEEHMASRTLAAGALGYVLKK 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498 115 ADADDVLTALLS--------------QQADVESLVPENPMSVDRLQWEHIQRVLAEHDGN------ISATARALGMHRRT 174
Cdd:PRK15369 108 SPQQILLAAIQTvavgkryidpalnrEAILALLNADDTNPPLLTPRERQILKLITEGYTNrdiaeqLSISIKTVETHRLN 187


                 ....*.
gi 764533498 175 LQRKLQ 180
Cdd:PRK15369 188 MMRKLD 193
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 14-125 5.04e-06

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 43.77  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSR-RGLRV-SVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILT 91
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQvPGFTViGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 764533498  92 GYSSIATAVEAIKRGATNYLCKPADADDVLTALL 125
Cdd:cd19925   82 AANDVETVREALRLGVVDYLIKPFTFERLRQRLE 115
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 15-114 6.06e-06

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 43.20  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd19935   81 SVEDRVKGLDLGADDYLVKP 100
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 16-94 9.76e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 42.72  E-value: 9.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDL-PDYAVLDLKMEG-DSGLVLLPKLLELDPDMRVVILTGY 93
Cdd:cd18161    2 LVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGPdIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLTSGY 81


                 .
gi 764533498  94 S 94
Cdd:cd18161   82 A 82
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 16-119 1.08e-05

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 42.62  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLAL--AKDDLPDYAVLDLKMEGDSGLVLLPKLLELdPDMRVVILTGY 93
Cdd:cd17584    2 LVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMlrENKDEFDLVITDVHMPDMDGFEFLELIRLE-MDLPVIMMSAD 80

                         90       100
                 ....*....|....*....|....*.
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADD 119
Cdd:cd17584   81 GSTSTVMKGLAHGACDYLLKPVSIED 106
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 15-121 1.40e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 42.40  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                         90       100
                 ....*....|....*....|....*..
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVL 121
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELV 107
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 16-114 1.42e-05

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 42.15  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDpDMRVVILTGYSS 95
Cdd:cd17620    2 LVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWS-AVPVIVLSARDE 80

                         90
                 ....*....|....*....
gi 764533498  96 IATAVEAIKRGATNYLCKP 114
Cdd:cd17620   81 ESDKIAALDAGADDYLTKP 99
HTH_30 pfam13556
PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the ...
 152-181 1.62e-05

PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.


Pssm-ID: 433305 [Multi-domain]  Cd Length: 56  Bit Score: 40.90  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 764533498  152 RVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:pfam13556   3 RAYLENGGNISATARALHVHRNTLRYRLRR 32
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
14-124 1.65e-05

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 43.69  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDdatftrvmaRAMSRRGLR-----------VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELD 82
Cdd:PRK10403   8 QVLIVDD---------HPLMRRGVRqlleldpgfevVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 764533498  83 PDMRVVILTGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:PRK10403  79 VTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
PRK10336 PRK10336
two-component system response regulator QseB;
15-135 2.19e-05

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 43.35  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTARD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 764533498  95 SIATAVEAIKRGATNYLCKPadaddvlTALLSQQADVESLV 135
Cdd:PRK10336  83 ALAERVEGLRLGADDYLCKP-------FALIEVAARLEALM 116
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 39-124 2.64e-05

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 41.87  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  39 VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSSIATAVEAIKRGATNYLCKPADAD 118
Cdd:cd19930   27 VAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAGVDGYVLKDRPIE 106


                 ....*.
gi 764533498 119 DVLTAL 124
Cdd:cd19930  107 ELADAI 112
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 15-114 2.92e-05

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 41.33  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLP-DYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGY 93
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILFISGG 81

                         90       100
                 ....*....|....*....|.
gi 764533498  94 SSIATAVEAIKRGATNYLCKP 114
Cdd:cd18160   82 AAAAPELLSDAVGDNATLKKP 102
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 16-124 3.91e-05

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 41.24  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVS-VAGSADEGLALAKDDLPDYAVLDLKMEGDsglvllpklleLD-----------P 83
Cdd:cd17534    4 LIVEDEAIIALDLKEILESLGYEVVgIADSGEEAIELAEENKPDLILMDINLKGD-----------MDgieaareirekF 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 764533498  84 DMRVVILTGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17534   73 DIPVIFLTAYSDEETLERAKETNPYGYLVKPFNERELKAAI 113
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 14-121 4.19e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 41.28  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMRVVILTGY 93
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESG-LDLLRTIRARSDVPIIIISGD 79

                         90       100
                 ....*....|....*....|....*....
gi 764533498  94 SSIATA-VEAIKRGATNYLCKPADADDVL 121
Cdd:cd17594   80 RRDEIDrVVGLELGADDYLAKPFGLRELL 108
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 13-124 5.05e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 41.20  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMsRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17596    1 PTILVVDDEVRSLEALRRTL-EEDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIISG 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  93 YSSIATAVEAIKRGAT-NYLCKPADADDVLTAL 124
Cdd:cd17596   80 YTDSEDIIAGINEAGIyQYLTKPWHPDQLLLTV 112
CdaR COG3835
Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];
152-181 5.47e-05

Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];


Pssm-ID: 443046 [Multi-domain]  Cd Length: 301  Bit Score: 42.32  E-value: 5.47e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 764533498 152 RVLAEHDGNISATARALGMHRRTLQRKLQK 181
Cdd:COG3835  244 RAYFENNGNISETAEALFIHRNTLRYRLKK 273
PRK10643 PRK10643
two-component system response regulator PmrA;
15-114 6.64e-05

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 41.94  E-value: 6.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK10643   3 ILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTARD 82

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:PRK10643  83 TLEDRVAGLDVGADDYLVKP 102
PRK09483 PRK09483
response regulator; Provisional
 16-137 8.05e-05

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 41.63  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDAtftrvMARAMSRRGLR----VSVAGSADEG---LALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVV 88
Cdd:PRK09483   5 LLVDDHE-----LVRAGIRRILEdikgIKVVGEACCGedaVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKII 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 764533498  89 ILTGYSSIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVESLVPE 137
Cdd:PRK09483  80 MLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASD 128
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 14-71 1.29e-04

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 39.88  E-value: 1.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRR-GLRV-SVAGSADEGLALAKDDLPDYAVLDLKMEGDSG 71
Cdd:COG2197    3 RVLIVDDHPLVREGLRALLEAEpDIEVvGEAADGEEALELLEELRPDVVLLDIRMPGMDG 62
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 15-114 1.97e-04

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 39.38  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMRVVILTGYS 94
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDG-IEVCRQIRAESGVPIVMLTAKS 81

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd17626   82 DTVDVVLGLESGADDYVAKP 101
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 14-124 2.32e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 39.32  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRRGL--RVSVAGSADEGLAL-------AKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPD 84
Cdd:cd17557    1 TILLVEDNPGDAELIQEAFKEAGVpnELHVVRDGEEALDFlrgegeyADAPRPDLILLDLNMPRMDG-FEVLREIKADPD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 764533498  85 MR---VVILTGYSSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd17557   80 LRripVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAI 122
ompR PRK09468
osmolarity response regulator; Provisional
 9-129 2.36e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 40.34  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498   9 GEEQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVV 88
Cdd:PRK09468   2 MQENYKILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPII 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 764533498  89 ILTGYSSIATAVEAIKRGATNYLCKPADADDVLT---ALLSQQA 129
Cdd:PRK09468  82 MLTAKGEEVDRIVGLEIGADDYLPKPFNPRELLArirAVLRRQA 125
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 39-124 3.54e-04

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 38.67  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  39 VSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYSSIatAVEAIKRGATNYLCKPADAD 118
Cdd:cd17532   27 VGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTAYDEY--AVEAFELNAVDYLLKPFSEE 104


                 ....*.
gi 764533498 119 DVLTAL 124
Cdd:cd17532  105 RLAEAL 110
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 16-115 3.61e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 38.53  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGlRVSVAGSA---DEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPdMRVVILTG 92
Cdd:cd17541    4 LIVDDSAVMRKLLSRILESDP-DIEVVGTArdgEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVMVSS 81

                         90       100
                 ....*....|....*....|....*
gi 764533498  93 YSS--IATAVEAIKRGATNYLCKPA 115
Cdd:cd17541   82 LTEegAEITLEALELGAVDFIAKPS 106
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 14-121 4.08e-04

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 38.51  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDpDMRVVILTGY 93
Cdd:cd19939    1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHS-HVPILMLTAR 79

                         90       100
                 ....*....|....*....|....*...
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADDVL 121
Cdd:cd19939   80 TEEMDRVLGLEMGADDYLCKPFSPRELL 107
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
15-182 4.91e-04

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 39.40  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAkDDLPDYAVLDLKMEGDSGLVLLPKLLELDpDMRVVILTGYS 94
Cdd:PRK10955   4 ILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLL-DDSIDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLTARG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLT---ALL------SQQADVESLVPEnpMSVDRLQ---------WEHIQ----- 151
Cdd:PRK10955  82 SELDRVLGLELGADDYLPKPFNDRELVArirAILrrshwsEQQQNNDNGSPT--LEVDALSlnpgrqeasFDGQTleltg 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 764533498 152 ------RVLAEHDGNISATA---------------RALGMHRRTLQRKLQKR 182
Cdd:PRK10955 160 teftllYLLAQHLGQVVSREhlsqevlgkrltpfdRAIDMHISNLRRKLPDR 211
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 15-166 5.66e-04

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 39.14  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK09836   3 LLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALG 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDVLTALLSQQADVESLVPENPMSVDRLQWEHIQRVLAEHDGNISATAR 166
Cdd:PRK09836  83 TIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSK 154
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 17-114 6.01e-04

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 37.42  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  17 LVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDpDMRVVILTGYSSI 96
Cdd:cd19936    3 LVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKS-TLPVIFLTSKDDE 81

                         90
                 ....*....|....*...
gi 764533498  97 ATAVEAIKRGATNYLCKP 114
Cdd:cd19936   82 IDEVFGLRMGADDYITKP 99
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 16-116 6.48e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 37.90  E-value: 6.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  16 LLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMR---VVILTG 92
Cdd:cd17548    3 LIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDG-LEATRLLKEDPATRdipVIALTA 81

                         90       100
                 ....*....|....*....|....
gi 764533498  93 YSSIATAVEAIKRGATNYLCKPAD 116
Cdd:cd17548   82 YAMKGDREKILEAGCDGYISKPID 105
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 15-114 7.37e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 37.56  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDpDMRVVILTGYS 94
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARS-NVPVIMVTAKD 79

                         90       100
                 ....*....|....*....|
gi 764533498  95 SIATAVEAIKRGATNYLCKP 114
Cdd:cd17621   80 SEIDKVVGLELGADDYVTKP 99
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 12-114 8.98e-04

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 38.63  E-value: 8.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  12 QPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPklleldpDMR----- 86
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIR-------DLRqwsai 73

                         90       100
                 ....*....|....*....|....*....
gi 764533498  87 -VVILTGYSSIATAVEAIKRGATNYLCKP 114
Cdd:PRK10529  74 pVIVLSARSEESDKIAALDAGADDYLSKP 102
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 13-116 9.01e-04

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 37.70  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  13 PHLLLVDDDATFTRVMARAMSRR---GLRVSVAGSADEGLALAKD-----DLPDYAVLDLKMEGDSGLVLLPKLLELDPD 84
Cdd:cd17595    1 PIILTVDDDPQVLRAVARDLRRQygkDYRVLRADSGAEALDALKElklrgEAVALFLVDQRMPEMDGVEFLEKAMELFPE 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 764533498  85 MRVVILTGYSSIATAVEAI-KRGATNYLCKPAD 116
Cdd:cd17595   81 AKRVLLTAYADTDAAIRAInDVQLDYYLLKPWD 113
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 14-66 1.01e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 37.53  E-value: 1.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 764533498  14 HLLLVDDDATFTRVMARAMSR-RGLRVSVAGSADEGLALAKDDLPDYAVLDLKM 66
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKlAGWEVLTASSGQEGLEKAATEQPDAILLDVMM 56
PRK10816 PRK10816
two-component system response regulator PhoP;
15-165 1.94e-03

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 37.80  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTGYS 94
Cdd:PRK10816   3 VLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARE 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 764533498  95 SIATAVEAIKRGATNYLCKPADADDV---LTALLSQQADVESLVpenpMSVDRLQWEHIQRVLAEHDGNISATA 165
Cdd:PRK10816  83 SWQDKVEVLSAGADDYVTKPFHIEEVmarMQALMRRNSGLASQV----ISLPPFQVDLSRRELSINDEVIKLTA 152
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 15-127 2.12e-03

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 36.65  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDaTFTRVMARAMSRRGLRVSVAGSAD--EGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVILTG 92
Cdd:cd17530    3 VLVLDDD-PFQCMMAATILEDLGPGNVDEADDgrEALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMSG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 764533498  93 YSSI-----ATAVEAIKRGATNYLCKPADAdDVLTALLSQ 127
Cdd:cd17530   82 LDGGilesaETLAGANGLNLLGTLSKPFSP-EELTELLTK 120
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 15-124 2.87e-03

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 36.24  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRV-SVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPdMRVVILTGY 93
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGYEVvGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLTAY 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 764533498  94 SSIATAVEAIKRGATNYLCKPADADDVLTAL 124
Cdd:cd19932   82 SQQDLVERAKEAGAMAYLVKPFSESDLIPAI 112
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 15-123 3.51e-03

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 35.87  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEG----------LALAKDDLPDYAVLDLkmegdsglvlLPKLLELDPD 84
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGeyyidirnydLVLVSDKLPDGNGLSI----------VSRIKEKHPS 70

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 764533498  85 MRVVILTGYSSIATAVEAIKRGATNYLCKPADAdDVLTA 123
Cdd:cd17573   71 IVVIVLSDNPKTEQEIEAFKEGADDYIAKPFDF-KVLVA 108
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 10-114 4.39e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 36.48  E-value: 4.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  10 EEQPHLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELDPDMRVVI 89
Cdd:PRK11083   1 MQQPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                         90       100
                 ....*....|....*....|....*
gi 764533498  90 LTGYSSIATAVEAIKRGATNYLCKP 114
Cdd:PRK11083  81 LTARSDEVDRLVGLEIGADDYVAKP 105
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 14-114 7.64e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 34.66  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  14 HLLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGLVLLPKLLELdPDMRVVILTGy 93
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRF-SDVPIIMVTA- 78

                         90       100
                 ....*....|....*....|....*..
gi 764533498  94 ssiatAVEAIKR------GATNYLCKP 114
Cdd:cd19938   79 -----RVEEIDRllglelGADDYICKP 100
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 15-114 9.31e-03

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 34.28  E-value: 9.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764533498  15 LLLVDDDATFTRVMARAMSRRGLRVSVAGSADEGLALAKDDLPDYAVLDLKMEGDSGlVLLPKLLELDPDMR---VVILT 91
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDG-YSLLGKLRKNADFDtipVIFLT 79

                         90       100
                 ....*....|....*....|...
gi 764533498  92 GYSSIATAVEAIKRGATNYLCKP 114
Cdd:cd19927   80 AKGMTSDRIKGYNAGCDGYLSKP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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