NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|765521556|ref|WP_044733791|]
View 

MULTISPECIES: iron ABC transporter permease [Shewanella]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 21-331 9.93e-91

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 273.48  E-value: 9.93e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  21 AAASGQYPLSLAQQGQALWHAIGGDVAALdsksisVFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSA 100
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADL------IVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 101 GAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPVlSLVLVGIAIGALCGAGISLMKLLADPYsQL 178
Cdd:COG0609   75 GAALGAVLAIVLggGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPL-RLVLAGVAVSALFSALTSLLLLLADPE-QL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 179 PSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAG 258
Cdd:COG0609  153 RSIVFWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAG 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 765521556 259 IIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFLLLRGG 331
Cdd:COG0609  233 PIGFVGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTIlAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 21-331 9.93e-91

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 273.48  E-value: 9.93e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  21 AAASGQYPLSLAQQGQALWHAIGGDVAALdsksisVFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSA 100
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADL------IVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 101 GAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPVlSLVLVGIAIGALCGAGISLMKLLADPYsQL 178
Cdd:COG0609   75 GAALGAVLAIVLggGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPL-RLVLAGVAVSALFSALTSLLLLLADPE-QL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 179 PSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAG 258
Cdd:COG0609  153 RSIVFWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAG 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 765521556 259 IIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFLLLRGG 331
Cdd:COG0609  233 PIGFVGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTIlAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 13-329 6.92e-70

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 220.09  E-value: 6.92e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   13 ICLSILCFAAASGQYPLSLAQQGQALWHAiggdvaaLDSKSISVFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVS 92
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGG-------DDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLAD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   93 PDILGVSAGAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPvLSLVLVGIAIGALCGAGISLMKL 170
Cdd:pfam01032  74 PSILGISSGAALGAVLAILLggSLSLFALPLAAFIGALLAALLVYFLSRGRGGASP-LRLILAGIAVSALLSALTSLLLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  171 LADPySQLPSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLT 250
Cdd:pfam01032 153 LLNP-EALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  251 AAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFLLLR 329
Cdd:pfam01032 232 AASVAVVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTIlSPYELPVGIVTALIGAPFFIYLLLR 311
btuC PRK09535
cobalamin ABC transporter permease BtuC;
60-329 7.96e-53

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 178.02  E-value: 7.96e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  60 LRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSAGAGLGAVLGIYLDLSV-YNIQLFAFLGGLLVVALVCLLA 138
Cdd:PRK09535  94 IRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVpFGLQAAAFAGALVAAFGVYAIA 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 139 rlSRQG-DPVLSLVLVGIAIGALCGAGISLMKLLADpySQLPSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWR 217
Cdd:PRK09535 174 --TENGrTPVATLLLAGVAVQTFLGAVISYLLLHSG--ESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARD 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 218 MNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLT 297
Cdd:PRK09535 250 LNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVAT 329

                        250       260       270
                 ....*....|....*....|....*....|..
gi 765521556 298 DTLARTlAPIELPLGILTACIGAPFFMFLLLR 329
Cdd:PRK09535 330 DTVARS-GPAEVPVGIVTAALGAPFFLYLLRT 360
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-327 5.48e-46

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 156.95  E-value: 5.48e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  83 QGMFRNPLVSPDILGVSAGAGLGAVLGIYLDLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPVLSLVLVGIAIGALCG 162
Cdd:cd06550   19 QSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGLSPSKLILIGIVLSAFFS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 163 AGISLMKLLADPYSQlpSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIF 242
Cdd:cd06550   99 AGVILISLLSDDSLQ--DLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 243 ILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTLAPIELPLGILTACIGAPF 322
Cdd:cd06550  177 LLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLLPSELPVGPVTALLGAPY 256


                 ....*
gi 765521556 323 FMFLL 327
Cdd:cd06550  257 FLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 21-331 9.93e-91

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 273.48  E-value: 9.93e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  21 AAASGQYPLSLAQQGQALWHAIGGDVAALdsksisVFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSA 100
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADL------IVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 101 GAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPVlSLVLVGIAIGALCGAGISLMKLLADPYsQL 178
Cdd:COG0609   75 GAALGAVLAIVLggGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPL-RLVLAGVAVSALFSALTSLLLLLADPE-QL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 179 PSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAG 258
Cdd:COG0609  153 RSIVFWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAG 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 765521556 259 IIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFLLLRGG 331
Cdd:COG0609  233 PIGFVGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTIlAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 13-329 6.92e-70

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 220.09  E-value: 6.92e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   13 ICLSILCFAAASGQYPLSLAQQGQALWHAiggdvaaLDSKSISVFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVS 92
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGG-------DDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLAD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   93 PDILGVSAGAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPvLSLVLVGIAIGALCGAGISLMKL 170
Cdd:pfam01032  74 PSILGISSGAALGAVLAILLggSLSLFALPLAAFIGALLAALLVYFLSRGRGGASP-LRLILAGIAVSALLSALTSLLLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  171 LADPySQLPSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLT 250
Cdd:pfam01032 153 LLNP-EALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  251 AAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFLLLR 329
Cdd:pfam01032 232 AASVAVVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTIlSPYELPVGIVTALIGAPFFIYLLLR 311
btuC PRK09535
cobalamin ABC transporter permease BtuC;
60-329 7.96e-53

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 178.02  E-value: 7.96e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  60 LRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSAGAGLGAVLGIYLDLSV-YNIQLFAFLGGLLVVALVCLLA 138
Cdd:PRK09535  94 IRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVpFGLQAAAFAGALVAAFGVYAIA 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 139 rlSRQG-DPVLSLVLVGIAIGALCGAGISLMKLLADpySQLPSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWR 217
Cdd:PRK09535 174 --TENGrTPVATLLLAGVAVQTFLGAVISYLLLHSG--ESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARD 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 218 MNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLT 297
Cdd:PRK09535 250 LNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVAT 329

                        250       260       270
                 ....*....|....*....|....*....|..
gi 765521556 298 DTLARTlAPIELPLGILTACIGAPFFMFLLLR 329
Cdd:PRK09535 330 DTVARS-GPAEVPVGIVTAALGAPFFLYLLRT 360
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 9-334 2.77e-51

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 173.00  E-value: 2.77e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   9 LATGICLSILCFAAASGQYPLSLAQqgqaLWHAIGGDVAALDSKsisVFWHLRLPRILAALMIGAGLAASGAAYQGMFRN 88
Cdd:COG4779   28 VLLLLLLALAVLALTLGDYPLSPGD----VLRALLGEGDPGASF---VVLELRLPRALAALLVGAALGLSGAIFQSLTRN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  89 PLVSPDILGVSAGAGLGAVLGI-YLDLSVYNIQLFAFLGGLLVVALVCLLARlsRQGDPVLSLVLVGIAIGALCGAGISL 167
Cdd:COG4779  101 PLASPDIIGITAGASAGAVAAIvVLGGSGLAVALGALAGGLATALLVYLLAW--RGGVSGYRLILVGIGVSAMLTAVNSY 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 168 MKLLADPYsQLPSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAAT 247
Cdd:COG4779  179 LLTRADLE-DAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAV 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 248 LLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPmSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFL 326
Cdd:COG4779  258 ALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLlAPVQLPVGVVTGALGGPYLLWL 336


                 ....*...
gi 765521556 327 LLRGGGRG 334
Cdd:COG4779  337 LIRENRRG 344
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 56-329 5.35e-46

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 158.86  E-value: 5.35e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  56 VFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSAGAGLGAVLGIYL---DLSVYNIQLFAFLGgllVVA 132
Cdd:COG4139   50 FVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLgggLLPPWLLSLAAIAG---ALL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 133 LVCLLARLSRQGDPVLSLVLVGIAIGALCGAGISLMKLLADPYSqLPSITFWLMGGLSDITLEDLkSSLLPMILGLVPLM 212
Cdd:COG4139  127 VTLLLLAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLD-LRQLMYWMMGSFGGVDWRQL-WLLLALLPVLLWLC 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 213 LLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAF 292
Cdd:COG4139  205 LQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAA 284

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 765521556 293 MLLLTDTLART-LAPIELPLGILTACIGAPFFMFLLLR 329
Cdd:COG4139  285 LLLLADIIARLaLSSAELPIGVVTATLGAPVFIWLLLR 322
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-327 5.48e-46

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 156.95  E-value: 5.48e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  83 QGMFRNPLVSPDILGVSAGAGLGAVLGIYLDLSVYNIQLFAFLGGLLVVALVCLLARLSRQGDPVLSLVLVGIAIGALCG 162
Cdd:cd06550   19 QSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGLSPSKLILIGIVLSAFFS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 163 AGISLMKLLADPYSQlpSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIF 242
Cdd:cd06550   99 AGVILISLLSDDSLQ--DLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 243 ILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTLAPIELPLGILTACIGAPF 322
Cdd:cd06550  177 LLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLLPSELPVGPVTALLGAPY 256


                 ....*
gi 765521556 323 FMFLL 327
Cdd:cd06550  257 FLYLL 261
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
60-331 1.63e-45

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 157.55  E-value: 1.63e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  60 LRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSAGAGLGAVLGIYLD---LSVYNIQLFAFLGGLLVVALVCL 136
Cdd:PRK11228  50 LRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSptpFAGYSLAFIAACGGGLSWLLVMT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 137 LARLSRQGDPVLSLVLVGIAIGALCGAGISLMKLLADPYSQlpSITFWLMGGLSDITLEDLKSsLLPMILGLVPLMLL-R 215
Cdd:PRK11228 130 AGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAY--GIFYWLAGGVSHARWQEVWQ-LLPFVVTAVPVVLLlA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 216 WRMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLL 295
Cdd:PRK11228 207 NQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLML 286

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 765521556 296 LTDTLARTLA-PIELPLGILTACIGAPFFMFLLLRGG 331
Cdd:PRK11228 287 LADLLARALAfPGELPAGAVLALIGAPCFVWLARRRG 323
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
7-329 7.28e-45

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 155.59  E-value: 7.28e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   7 YPLATGICLSILCFAAASGQYPLSlaqqgqalWHAIGGDVAAlDSKSISVFWHLRLPRILAALMIGAGLAASGAAYQGMF 86
Cdd:PRK09777   6 VIFITLALAGCALLSLRMGVIPLP--------WRALLTDWQA-GDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  87 RNPLVSPDILGVSAGAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLSRQgdpvLSLVLVGIAIGAlCGAG 164
Cdd:PRK09777  77 RNPLASPDILGVNHAASLASVGALLLfpSLPVMWLPLLAFIGGMAGLILLKMLAGTHQP----MKLALTGVALSA-LWAS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 165 ISLMKLLADPySQLPSITFWLMGGLSDITLEDLkSSLLPMILGLVPLMLLRWR-MNLLSLADDEASSLGLNIAKTRLIFI 243
Cdd:PRK09777 152 LTDYLMLSRP-QDINNALLWLTGSLWGRDWSFV-KVALPWLILLLPLSLSFCRdLDLLALGDARATTLGVSVPHTQFWAL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 244 LAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTLA-PIELPLGILTACIGAPF 322
Cdd:PRK09777 230 LLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHpPLELPAGVLTAIIGAPW 309


                 ....*..
gi 765521556 323 FMFLLLR 329
Cdd:PRK09777 310 FFWLLVR 316
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
7-333 6.72e-43

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 156.92  E-value: 6.72e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   7 YPLATGICLSILCFAAAsgqyplsLAQQGQALWHAIGGDVAALdsksisvFWHLRLPRILAALMIGAGLAASGAAYQGMF 86
Cdd:PRK10577 357 WLLALGLLLLLALVVAL-------SFGRDAHGWNWLSGQLLDA-------LLPLRLPRLLAALLAGAMLAVAGTLLQRLT 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  87 RNPLVSPDILGVSAGAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARlsRQGDPVLSLVLVGIAIGALCGAG 164
Cdd:PRK10577 423 RNPLASPEVLGISSGAGLGVVLALFLvpGAGFGWLLAAALLGALAALALILLLAR--RGGFAPERLLLTGIALSALFTAL 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 165 ISLMKLLADPysQLPSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFIL 244
Cdd:PRK10577 501 IQLLLASGDP--RAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLL 578

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 245 AATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLART-LAPIELPLGILTACIGAPFF 323
Cdd:PRK10577 579 LAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTlLFPYQIPAGLLAALIGAPYF 658

                        330
                 ....*....|
gi 765521556 324 MFLLLRGGGR 333
Cdd:PRK10577 659 LWLLRRSRRR 668
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 58-329 4.26e-42

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 148.95  E-value: 4.26e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  58 WHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSAGAGLGAVLGIYLDLSVYNIQLFAFLGGLLVVALVCLL 137
Cdd:PRK03784  55 WQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITLIL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 138 ARLSRQGDPVLS-LVLVGIAIGALCGAGISLMKLLADPYSqLPSITFWLMGGLSDITLEdLKSSLLPMILGLVPLMLLRW 216
Cdd:PRK03784 135 LRFARRHRLSTSrLLLAGVALGIICSALMTWAVYFSTSLD-LRQLMYWMMGGFGGVDWR-QSWLMLALLPVLIWLCCQGR 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 217 RMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLL 296
Cdd:PRK03784 213 PLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLL 292

                        250       260       270
                 ....*....|....*....|....*....|....
gi 765521556 297 TDTLART-LAPIELPLGILTACIGAPFFMFLLLR 329
Cdd:PRK03784 293 ADIVARLaLASAELPIGVVTATLGAPVFIWLLLR 326
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
9-335 7.76e-42

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 153.84  E-value: 7.76e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556   9 LATGICLSILCFAAASGQYPLSLAQQGQALWHAIGGDVAALdsksisVFWHLRLPRILAALMIGAGLAASGAAYQGMFRN 88
Cdd:PRK10577  16 LLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQL------LLHYSRLPRLAIALLVGAALGLAGALLQQVLRN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  89 PLVSPDILGVSAGAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLLARLsRQGDPvLSLVLVGIAIGALCGAGIS 166
Cdd:PRK10577  90 PLASPTTLGVAAGAQLALVLATLFapALLALASQLAAFAGGLLAAALVFALAGG-KRLSP-LRLVLAGMVVSLYLGALTT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 167 LMKLLADPYSQlpSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAA 246
Cdd:PRK10577 168 LLLLFNEQYLQ--GLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 247 TLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLLTDTLARTLAP---IELPLGILTACIGAPFF 323
Cdd:PRK10577 246 VLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGvggELLPTGAVTALIGAPLL 325

                        330
                 ....*....|..
gi 765521556 324 MFLLLRGGGRGQ 335
Cdd:PRK10577 326 LWLLPRLRSAQS 337
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
61-334 6.27e-32

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 121.74  E-value: 6.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  61 RLPRILAALMIGAGLAASGAAYQGMFRNPLVSPDILGVSAGAGLGAVLGIYL--DLSVYNIQLFAFLGGLLVVALVCLL- 137
Cdd:PRK10441  60 RLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALfgYSSAQEQLAMAFAGALVASLIVAFTg 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 138 ARLSRQGDPVlSLVLVGIAIGA-LCGAGISLMKLLADPYSQLpsiTFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRW 216
Cdd:PRK10441 140 SQGGGQLSPV-RLTLAGVALAAvLEGLTSGIALLNPDVYDQL---RFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSR 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 217 RMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAAAVSIAGIIGWLGLVVPHIARMLVGADFRRLLPMSMLLGAFMLLL 296
Cdd:PRK10441 216 ALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLF 295

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 765521556 297 TDTLARTLAPIELPLGILTACIGAPFFMFLLLRGGGRG 334
Cdd:PRK10441 296 ADIIGRLLVPGELRVSVVSAFIGAPVLIFLVRRKTRGG 333
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
14-333 2.17e-30

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 117.50  E-value: 2.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  14 CLSILCFAAASGQYPLSLAQQGQALWHAIGGDVAAldsksisVFWHLRLPRILAALMIGAGLAASGAAYQGMFRNPLVSP 93
Cdd:PRK10440  19 CVAAGLWGLRSGAVTLETSQVFAALMGDAPRSMTM-------VVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556  94 DILGVSAGAGLGAVLGIYL-DLSVYNIQLFAFLGGLLVVALVCLLARlsRQGDPVLSLVLVGIAIGALCGAGISLMKLLA 172
Cdd:PRK10440  92 DVMGFNTGAWSGVLVAMVLfGQDLTAIALAAMAGGIVTSLLVWLLAW--RNGIDTFRLIIIGIGVRAMLVAFNTWLLLKA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 173 DPYSQLpSITFWLMGGLSDITLEDLKSSLLPMILGLVPLMLLRWRMNLLSLADDEASSLGLNIAKTRLIFILAATLLTAA 252
Cdd:PRK10440 170 SLETAL-TAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521556 253 AVSIAGIIGWLGLVVPHIARMLVGADfRRLLPMSMLLGAFMLLLTDTLARTL-APIELPLGILTACIGAPFFMFLLLRGG 331
Cdd:PRK10440 249 ATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLfMPYQLPVGVVTVSLGGIYLIVLLIQES 327


                 ..
gi 765521556 332 GR 333
Cdd:PRK10440 328 RK 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH