|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
23-350 |
5.80e-68 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 219.45 E-value: 5.80e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 23 REAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTI---------INRAFAPQKDDGHEV 90
Cdd:COG5000 83 EELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPleeLIGKPLEELlpeldlaelLREALERGWQEEIEL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 91 SLRNGRRVKLAITPLtPEQGQLIMLTDLTEtrLLQQnlshlERLSALGKMVATLAHQIRTPLSAALLYAANLGS--PRLD 168
Cdd:COG5000 163 TRDGRRTLLVRASPL-RDDGYVIVFDDITE--LLRA-----ERLAAWGELARRIAHEIKNPLTPIQLSAERLRRklADKL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 169 AGSRERFQ---GKLLDRLSELEQQVNDMLLIAKGKQEEAcDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGDS-EMQV 244
Cdd:COG5000 235 EEDREDLEralDTIIRQVDRLKRIVDEFLDFARLPEPQL-EPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLA 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 245 NLHGLSSAINNLVINSLEAGATRVILRLSC---DQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVR 321
Cdd:COG5000 314 DRDQLEQVLINLLKNAIEAIEEGGEIEVSTrreDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVE 393
|
330 340
....*....|....*....|....*....
gi 765521844 322 SHGGKLDLSCKLGAGCTVTLTFPLTTDSQ 350
Cdd:COG5000 394 EHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
24-350 |
3.25e-60 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 197.38 E-value: 3.25e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 24 EAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRW----------LTIINRAFAPQKD-DGHE 89
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSaeeLLGRPLaelfpedsplRELLERALAEGQPvTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 90 VSLRNG----RRVKLAITPLTPEQGQ---LIMLTDLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANL 162
Cdd:COG3852 81 VTLRRKdgeeRPVDVSVSPLRDAEGEggvLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 163 GSPRLDAGSRERFQ--GKLLDRLSELeqqVNDMLLIAKGKQEEacdRVPFS--TVLEKVMANCEPiAARQNVELSLQ--- 235
Cdd:COG3852 161 ERELPDDELREYTQliIEEADRLNNL---VDRLLSFSRPRPPE---REPVNlhEVLERVLELLRA-EAPKNIRIVRDydp 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 236 ----IEGDSEMqvnlhgLSSAINNLVINSLEAGA--------TRV-----ILRLSCDQTLRLDVIDNGKGLDSKMQKQVL 298
Cdd:COG3852 234 slpeVLGDPDQ------LIQVLLNLVRNAAEAMPeggtitirTRVerqvtLGGLRPRLYVRIEVIDNGPGIPEEILDRIF 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 765521844 299 EPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTTDSQ 350
Cdd:COG3852 308 EPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
28-350 |
1.08e-48 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 170.54 E-value: 1.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 28 MSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGV---------------PLVGQRWLTIINRAFAPQKD-DGHEVS 91
Cdd:COG5809 139 SEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGIsieeligksilelihSDDQENVAAFISQLLKDGGIaQGEVRF 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 92 LR-NGRRVKL--AITPLTPE---QGQLIMLTDLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSA-----ALLYAA 160
Cdd:COG5809 219 WTkDGRWRLLeaSGAPIKKNgevDGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSlkgfiQLLKDT 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 161 NL--GSPRLDAGSRErfqgklLDRlseLEQQVNDMLLIAKgKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEG 238
Cdd:COG5809 299 IDeeQKTYLDIMLSE------LDR---IESIISEFLVLAK-PQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELED 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 239 DSEM---------QVNLhglssainNLVINSLEA----GATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTK 305
Cdd:COG5809 369 DIPDilgdenqlkQVFI--------NLLKNAIEAmpegGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTK 440
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 765521844 306 RQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTTDSQ 350
Cdd:COG5809 441 EKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
58-346 |
3.75e-45 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 157.38 E-value: 3.75e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 58 VAESLLGVPLVGQRWLTIINRAFAPQKDDGHEVSLRNGRRVKLAITPLTPEQGQLIMLTDLTETRLLQQNLSHLERLS-A 136
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANeA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 137 LGKMVATLAHQIRTPLSAALLYAANLGSpRLDAGSRERFQgKLLDRLSELEQQVNDMLLIAK---GKQEEACDRVPFSTV 213
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLE-ELDEEQREYLE-TILRSADRLLRLINDLLDLSRleaGKLELEPEPVDLAEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 214 LEKVMANCEPIAARQNVELSLQIEGDSE-MQVNLHGLSSAINNLVINSLEAGA--TRVILRLSCD-QTLRLDVIDNGKGL 289
Cdd:COG0642 188 LEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRREgDRVRISVEDTGPGI 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 765521844 290 DSKMQKQVLEPFFTTKR----QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLT 346
Cdd:COG0642 268 PPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
117-346 |
7.39e-44 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 154.96 E-value: 7.39e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 117 DLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANLGSPRLDAGSRERFQGKL------LDRLSELeqqV 190
Cdd:COG4191 122 AEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPEELREALerilegAERAAEI---V 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 191 NDMLLIAKgKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGD-SEMQVNLHGLSSAINNLVINSLEA---GAT 266
Cdd:COG4191 199 RSLRAFSR-RDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDlPPVLGDPGQLEQVLLNLLINAIDAmeeGEG 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 267 RVI-LRLSCD-QTLRLDVIDNGKGLDSKMQKQVLEPFFTTKR--QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLT 342
Cdd:COG4191 278 GRItISTRREgDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTIT 357
|
....
gi 765521844 343 FPLT 346
Cdd:COG4191 358 LPLA 361
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
124-347 |
8.69e-42 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 145.82 E-value: 8.69e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 124 LQQNLSHLERLSAL-GKMVATLAHQIRTPLSAALLYAANLG-SPRLDAGSRERFQGKLLDRLSELEQQVNDMLLIAK--- 198
Cdd:COG2205 2 LEEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLdEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRles 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 199 GKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGDSEM-QVNLHGLSSAINNLVINSLEAG--ATRVILRLSC- 274
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLvYADPELLEQVLANLLDNAIKYSppGGTITISARRe 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 765521844 275 DQTLRLDVIDNGKGLDSKMQKQVLEPFF----TTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTT 347
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
30-346 |
7.54e-41 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 149.50 E-value: 7.54e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 30 NRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTIINRAFAPQ--------KDDGHEVSL------ 92
Cdd:COG5805 157 ERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPreeLIGKNLLELLHPCDKEEfkeriesiTEVWQEFIIereiit 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 93 RNGR------RVKLAITPLTPEQGQLIMLTDLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSA--ALLyaaNLGS 164
Cdd:COG5805 237 KDGRiryfeaVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSikGFL---QLLQ 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 165 PRLDagSRERFQGKLLDRLSELEQQVNDMLLIAKGKQEeacDRVPFS--TVLEKVMANCEPIAARQNVELSLQ------- 235
Cdd:COG5805 314 PGIE--DKEEYFDIMLSELDRIESIISEFLALAKPQAV---NKEKENinELIQDVVTLLETEAILHNIQIRLElldedpf 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 236 IEGD-SEM-QVnlhglssaINNLVINSLEA---GATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTG 310
Cdd:COG5805 389 IYCDeNQIkQV--------FINLIKNAIEAmpnGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTG 460
|
330 340 350
....*....|....*....|....*....|....*.
gi 765521844 311 LGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLT 346
Cdd:COG5805 461 LGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
17-348 |
2.70e-38 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 140.84 E-value: 2.70e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 17 REWIPVREAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVPLVGQRWLTIINRAFAPQKDDGHEVSLRNGR 96
Cdd:COG5002 44 LLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 97 RVKLAITPLTPEQGQLIMLTDLTETRLLQQNLSHLERLSALGK-MVATLAHQIRTPLSAALLYAANL-GSPRLDAGSRER 174
Cdd:COG5002 124 LLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRReFVANVSHELRTPLTSIRGYLELLlDGAADDPEERRE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 175 FQGKLL---DRLSELeqqVNDMLLIAK---GKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGDS-EMQVNLH 247
Cdd:COG5002 204 YLEIILeeaERLSRL---VNDLLDLSRlesGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPlLVLGDPD 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 248 GLSSAINNLVINSLEAGA--TRVILRLSC-DQTLRLDVIDNGKGLDSKMQKQVLEPFFTT------KRQGTGLGLAVVQS 318
Cdd:COG5002 281 RLEQVLTNLLDNAIKYTPegGTITVSLREeDDQVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLAIVKH 360
|
330 340 350
....*....|....*....|....*....|
gi 765521844 319 VVRSHGGKLDLSCKLGAGCTVTLTFPLTTD 348
Cdd:COG5002 361 IVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
30-345 |
4.61e-37 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 140.49 E-value: 4.61e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 30 NRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRwltiINRAFAPQKDDGHEV--SLRNGRRVK-LAIT 103
Cdd:PRK11360 262 SLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQrheLVGKP----YSELFPPNTPFASPLldTLEHGTEHVdLEIS 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 104 PLTPEQGQLIMLT-------------------DLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANLGS 164
Cdd:PRK11360 338 FPGRDRTIELSVStsllhnthgemigalvifsDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQ 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 165 PRLDAGSRErFQGKLLDRLSELEQQVNDMLLIAKgKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGD-SEMQ 243
Cdd:PRK11360 418 QTSDPPSQE-YLSVVLREVDRLNKVIDQLLEFSR-PRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNElPPIW 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 244 VNLHGLSSAINNLVINSLEA----GATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSV 319
Cdd:PRK11360 496 ADPELLKQVLLNILINAVQAisarGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRI 575
|
330 340
....*....|....*....|....*.
gi 765521844 320 VRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:PRK11360 576 INAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
32-345 |
2.23e-35 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 132.22 E-value: 2.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 32 MEHILQAMPSGVVILNGDGLVSEANPVAESLLG---VPLVGQRWLT---IINRAFAPQK---DDGHEVSLRNGRRVKLAI 102
Cdd:COG5807 29 FKQLFDSILEFVFFIDSKGEILECNDFAEDLYGlsqNEYIGKTFVEekcILKDEQLYNKeafDRIEISYLTKNGEFDEII 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 103 TPLTPEQGQ----LIMLTDLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANLGSPRLDAgSRERFQGK 178
Cdd:COG5807 109 YPIYYKDGVilglITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDS-EREEYFNI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 179 LLDRLSELEQQVNDMLLIAKgKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIE-GDSEMQVNLHGLSSAINNLV 257
Cdd:COG5807 188 IISEIDRINTIITELLVLSK-PKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLAdDEPVINGDKNQLKQVFINLI 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 258 INSLEAGATRVILRLSC---DQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLG 334
Cdd:COG5807 267 KNAIEAMETGGNITIKTyveGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPG 346
|
330
....*....|.
gi 765521844 335 AGCTVTLTFPL 345
Cdd:COG5807 347 KGTTFTIYLPL 357
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
120-345 |
2.68e-33 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 127.68 E-value: 2.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 120 ETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANLGSPRLDAGSRERFQGKLLDRLSELEQQVNDMLLIAKg 199
Cdd:COG5806 184 ENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAK- 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 200 KQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGDSEMQVNLHGLSSAINNLVINSLEA----GATRVILRLScD 275
Cdd:COG5806 263 PQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAmpngGTLTIDVSID-K 341
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 276 QTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:COG5806 342 NKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
122-345 |
3.26e-32 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 125.25 E-value: 3.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 122 RLLQQNlsHLERLSALGKMVATLAHQIRTPLSAALLYAANLgspRLDAGSRErfQGKLLD----RLSELEQQVNDMLLIA 197
Cdd:COG5808 228 RVIQEI--NTQKLELIGTFAASTAHEIRNPLTSIKGFIQLL---QEKYPELE--DQKYFDiiqeEIQRINQIVSEFLVLG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 198 K--GKQEEACDrvpFSTVLEKVMANCEPIAARQNVELSLQ-IEGDSEMQVNLHGLSSAINNLVINSLEAGATR--VILRL 272
Cdd:COG5808 301 KptAKKLELDD---LNELIEEILSIIDSEANLKNIRVEKQsLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGgkLTISI 377
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 765521844 273 SCDQT-LRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:COG5808 378 ENDDEkAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
18-345 |
1.09e-30 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 119.95 E-value: 1.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 18 EWIPVREAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVPLVGQRWLTIINRAFAPQKDDghEVSLRNGRR 97
Cdd:COG3290 72 LLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERD--EEILLNGRV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 98 VKLAITPLTPE---QGQLIMLTDLTETRLLQQNLSHLERLSalgKMVATLAHQIRTPLSAaLLYAANLGSPRlDAGsrer 174
Cdd:COG3290 150 LVVNRVPIRDDgrvVGAVATFRDRTELERLEEELEGVKELA---EALRAQRHDFRNHLHT-ISGLLQLGEYD-EAL---- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 175 fqgKLLDRLSELEQQVNDMLLIAkgkqeeaCDRVPFSTVLEKVMAncepIAARQNVELSLQIEGD-SEMQVNLHGLSSAI 253
Cdd:COG3290 221 ---EYIDEISEELQELIDSLLSR-------IGNPVLAALLLGKAA----RARERGIDLTIDIDSDlPDLPLSDTDLVTIL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 254 NNLVINSLEA------GATRVILRLSCDQ-TLRLDVIDNGKGLDSKMQKQVLEPFFTTKR-QGTGLGLAVVQSVVRSHGG 325
Cdd:COG3290 287 GNLLDNAIEAveklpeEERRVELSIRDDGdELVIEVEDSGPGIPEELLEKIFERGFSTKLgEGRGLGLALVKQIVEKYGG 366
|
330 340
....*....|....*....|
gi 765521844 326 KLDLSCKLGAGCTVTLTFPL 345
Cdd:COG3290 367 TIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
248-346 |
1.79e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.48 E-value: 1.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 248 GLSSAINNLVINSLEAGATRVILRLSCDQT---LRLDVIDNGKGLDSKMQKQVLEPFFTTK-----RQGTGLGLAVVQSV 319
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRITVTLERDgdhVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSIVKKL 84
|
90 100
....*....|....*....|....*..
gi 765521844 320 VRSHGGKLDLSCKLGAGCTVTLTFPLT 346
Cdd:smart00387 85 VELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
248-347 |
3.41e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 92.43 E-value: 3.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 248 GLSSAINNLVINSLE--AGATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFT---TKRQGTGLGLAVVQSVVRS 322
Cdd:pfam02518 5 RLRQVLSNLLDNALKhaAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLVEL 84
|
90 100
....*....|....*....|....*
gi 765521844 323 HGGKLDLSCKLGAGCTVTLTFPLTT 347
Cdd:pfam02518 85 LGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
249-343 |
1.17e-22 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 90.74 E-value: 1.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGA--TRVILRLSCD-QTLRLDVIDNGKGLDSKMQKQVLEPFFTTK----RQGTGLGLAVVQSVVR 321
Cdd:cd00075 1 LEQVLSNLLDNALKYSPpgGTIEISLRQEgDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 765521844 322 SHGGKLDLSCKLGAGCTVTLTF 343
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
122-345 |
1.42e-22 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 98.32 E-value: 1.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 122 RLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANLGSpRLDAGSRER----FQGKLLDRLSELeqqVNDMLLIA 197
Cdd:PRK10364 222 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAE-RAPAGGEAHqlaqVMAKEADRLNRV---VSELLELV 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 198 KgKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQI-EGDSEMQVNLHGLSSAINNLVINSLEA---GATRVILRLS 273
Cdd:PRK10364 298 K-PTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTAnDTLPEIQADPDRLTQVLLNLYLNAIQAigqHGVISVTASE 376
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 765521844 274 CDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:PRK10364 377 SGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
141-345 |
1.88e-21 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 94.91 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 141 VATLAHQIRTPLsAALLYAANLGSPRLDAGSRERFQGKLLDRLSELEQQVNDMLLIAK---GKQEEACDRVPFSTVLEKV 217
Cdd:PRK11100 260 VQTLTHELKSPL-AAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARleqRQELEVLEPVALAALLEEL 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 218 MANCEPIAARQNVELSLQ-----IEGDSEMqvnlhgLSSAINNLVINSLEAGATRVILRLSCDQT---LRLDVIDNGKGL 289
Cdd:PRK11100 339 VEAREAQAAAKGITLRLRpddarVLGDPFL------LRQALGNLLDNAIDFSPEGGTITLSAEVDgeqVALSVEDQGPGI 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 765521844 290 DSKMQKQVLEPFFT-----TKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:PRK11100 413 PDYALPRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
23-344 |
5.66e-20 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 91.00 E-value: 5.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 23 REAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVPLVGQRWLTIINRAFAPQKDDGHEVSLRNGRRVKLAI 102
Cdd:COG4251 167 ILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 103 TPLTPEQGQLIMLTDLTETRLLQQNLSHLERLSA-LGKMVATLAHQIRTPLSAALLYA---ANLGSPRLDAGSRERFQgK 178
Cdd:COG4251 247 LLILVLELLELRLELEELEEELEERTAELERSNEeLEQFAYVASHDLREPLRKISGFSqllEEDYGDKLDEEGREYLE-R 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 179 LLDRLSELEQQVNDMLLIAK-GKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQ----IEGDSEMqvnlhgLSSAI 253
Cdd:COG4251 326 IRDAAERMQALIDDLLAYSRvGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGplptVRGDPTL------LRQVF 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 254 NNLVINSLE--AGATRVILRLSCDQT---LRLDVIDNGKGLDSKMQKQVLEPFFT----TKRQGTGLGLAVVQSVVRSHG 324
Cdd:COG4251 400 QNLISNAIKysRPGEPPRIEIGAEREggeWVFSVRDNGIGIDPEYAEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHG 479
|
330 340
....*....|....*....|
gi 765521844 325 GKLDLSCKLGAGCTVTLTFP 344
Cdd:COG4251 480 GRIWVESEPGEGATFYFTLP 499
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
255-344 |
5.46e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 80.90 E-value: 5.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 255 NLVINSLEA----GATRVILRL----SCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGK 326
Cdd:cd16920 7 NLVRNGIEAmsegGCERRELTIrtspADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86
|
90
....*....|....*...
gi 765521844 327 LDLSCKLGAGCTVTLTFP 344
Cdd:cd16920 87 LSVESPAGGGATFQFTLP 104
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
23-344 |
8.03e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 86.99 E-value: 8.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 23 REAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVplvgqRW-----LTIINRAFAP------QKDD---GH 88
Cdd:PRK11006 91 RELGNLIKRFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGF-----RWpedngQNILNLLRYPeftqylKTRDfsrPL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 89 EVSLRNGRRVKLAITPLTpeQGQLIMLT-DLTETRLLQqnlshlerlSALGKMVATLAHQIRTPLSAALLYAANLGSPRL 167
Cdd:PRK11006 166 TLVLNNGRHLEIRVMPYT--EGQLLMVArDVTQMHQLE---------GARRNFFANVSHELRTPLTVLQGYLEMMQDQPL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 168 DAGSRERFQGKLLDRLSELEQQVNDMLLIAK---GKQEEACDRVPFSTVLEKVMANCEPIAARQ-----NVELSLQIEGD 239
Cdd:PRK11006 235 EGALREKALHTMREQTQRMEGLVKQLLTLSKieaAPTIDLNEKVDVPMMLRVLEREAQTLSQGKhtitfEVDNSLKVFGN 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 240 SEMqvnlhgLSSAINNLVINSLE---AGATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFF----TTKRQ--GTG 310
Cdd:PRK11006 315 EDQ------LRSAISNLVYNAVNhtpEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkARSRQtgGSG 388
|
330 340 350
....*....|....*....|....*....|....
gi 765521844 311 LGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:PRK11006 389 LGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-344 |
2.88e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 79.12 E-value: 2.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEA------GATRVILRLSCDQTLR--LDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVV 320
Cdd:cd16944 5 ISQVLTNILKNAAEAiegrpsDVGEVRIRVEADQDGRivLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIM 84
|
90 100
....*....|....*....|....
gi 765521844 321 RSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16944 85 EEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
119-347 |
1.20e-17 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 84.34 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 119 TETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAaNLGSPRLDAGSRERFQGKLLDRLSELEQQVNDMLLIAK 198
Cdd:PRK13837 432 TERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYA-EMALNKLARHSRAARYIDEIISAGARARLIIDQILAFG 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 199 GKQEEACDRVPFSTVLEKVMANCEpIAARQNVELSLQ-------IEGDSEmqvnlhGLSSAINNLVINSLEA--GATRVI 269
Cdd:PRK13837 511 RKGERNTKPFDLSELVTEIAPLLR-VSLPPGVELDFDqdqepavVEGNPA------ELQQVLMNLCSNAAQAmdGAGRVD 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 270 LRLS----------CDQTL------RLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKL 333
Cdd:PRK13837 584 ISLSraklrapkvlSHGVLppgryvLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTV 663
|
250
....*....|....
gi 765521844 334 GAGCTVTLTFPLTT 347
Cdd:PRK13837 664 GRGTRFDVYLPPSS 677
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
255-345 |
1.82e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 77.08 E-value: 1.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 255 NLVINSLEA--GATRVILRLSC-DQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKR--QGTGLGLAVVQSVVRSHGGKLDL 329
Cdd:cd16943 10 NLLVNAAQAmeGRGRITIRTWAhVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKHGGTIRV 89
|
90
....*....|....*.
gi 765521844 330 SCKLGAGCTVTLTFPL 345
Cdd:cd16943 90 ASVPGGGTRFTIILPI 105
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
91-344 |
1.63e-16 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 80.12 E-value: 1.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 91 SLRNGRRVKLAITPLTPEQ-GQLIMLTDL-TETRLLQQNLSH-LERLSA----LGKMVATLAHQIRTPLSAALLYA-ANL 162
Cdd:TIGR01386 188 GLEPLRRLSAVAARISPESlDQRLDPSRApAELRELAQSFNAmLGRLEDafqrLSQFSADLAHELRTPLTNLLGQTqVAL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 163 GSPRLDAGSRERFQGKL--LDRLSELeqqVNDMLLIAKGKQEE-ACDRVPFS--TVLEKVMANCEPIAARQNVEL----S 233
Cdd:TIGR01386 268 SQPRTGEEYREVLESNLeeLERLSRM---VSDMLFLARADNGQlALERVRLDlaAELAKVAEYFEPLAEERGVRIrvegE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 234 LQIEGDSEMqvnlhgLSSAINNLVINSL----EAGATRVILRLSCDQTlRLDVIDNGKGLDSKMQKQVLEPFF------T 303
Cdd:TIGR01386 345 GLVRGDPQM------FRRAISNLLSNALrhtpDGGTITVRIERRSDEV-RVSVSNPGPGIPPEHLSRLFDRFYrvdparS 417
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 765521844 304 TKRQGTGLGLAVVQSVVRSHGGklDLSCKLGAGCTV-TLTFP 344
Cdd:TIGR01386 418 NSGEGTGLGLAIVRSIMEAHGG--RASAESPDGKTRfILRFP 457
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
125-344 |
2.11e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 77.42 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 125 QQNLSHLERLSALGKMVATLAHQIRTPLSA--ALLYAANLgspRLDAGSRERFQgkllDRLSELEQQVNDMLLIAKG--- 199
Cdd:COG4192 421 QDELIQAAKMAVVGQTMTSLAHELNQPLNAmsMYLFSAKK---ALEQENYAQLP----TSLDKIEGLIERMDKIIKSlrq 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 200 ---KQEEACDRVPFSTVLEKVMANCEPIAARQNVelSLQIEGDSEMQVNLHGLSSAINNLVINSLEAGATRV---ILRLS 273
Cdd:COG4192 494 fsrKSDTPLQPVDLRQVIEQAWELVESRAKPQQI--TLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPqisVDLLS 571
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 765521844 274 CDQTLRLDVIDNGKGLDSkmQKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:COG4192 572 NAENLRVAISDNGNGWPL--VDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-339 |
1.34e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 68.97 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGATR---VILRLSCDQ-----------TLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGTGLGLA 314
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeIILRTRTQRqvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100
....*....|....*....|....*
gi 765521844 315 VVQSVVRSHGGKLDlsCKLGAGCTV 339
Cdd:cd16918 81 IAQNIVSQHGGVIE--CDSQPGHTV 103
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
253-345 |
1.97e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 68.67 E-value: 1.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 253 INNLVINSL---EAGAtrVILRLSCDQT------LRLDVIDNGKGLDSKMQKQVLEPF------FTTKRQGTGLGLAVVQ 317
Cdd:cd16922 5 LLNLLGNAIkftEEGE--VTLRVSLEEEeedgvqLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAISK 82
|
90 100
....*....|....*....|....*...
gi 765521844 318 SVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:cd16922 83 KLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
100-348 |
9.00e-14 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 72.01 E-value: 9.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 100 LAITPLTPEQGQLIML----TDLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLY----AANLGSPRLDAGS 171
Cdd:PRK13557 122 LFVSPVYNDAGDLVYFfgsqLDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYldviQAALSHPDADRGR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 172 RERFQGKL---LDRLSELEQQvndmLLIAKGKQeeacdRVPFSTV-LEKVMANCEPIAAR---QNVELSLQIEGD-SEMQ 243
Cdd:PRK13557 202 MARSVENIraaAERAATLTQQ----LLAFARKQ-----RLEGRVLnLNGLVSGMGELAERtlgDAVTIETDLAPDlWNCR 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 244 VNLHGLSSAINNLVINSLEA--GATRVILRLSCDQTLRLD----------------VIDNGKGLDSKMQKQVLEPFFTTK 305
Cdd:PRK13557 273 IDPTQAEVALLNVLINARDAmpEGGRVTIRTRNVEIEDEDlamyhglppgryvsiaVTDTGSGMPPEILARVMDPFFTTK 352
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 765521844 306 R--QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTTD 348
Cdd:PRK13557 353 EegKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQ 397
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
249-344 |
6.01e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 64.71 E-value: 6.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVIN---------SLEAGATRVIL---------RLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKR--QG 308
Cdd:cd16919 1 LELAILNLAVNardampeggRLTIETSNQRVdadyalnyrDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 765521844 309 TGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
117-350 |
1.55e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 68.99 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 117 DLTETRLLQQNLsHLERLSALGKMVA------TLAHQIRTPLSA-----ALLYAANLGSP-RLDAGSRERFQGKlldRLS 184
Cdd:PRK09959 687 DITETRDLIHAL-EVERNKAINATVAksqflaTMSHEIRTPISSimgflELLSGSGLSKEqRVEAISLAYATGQ---SLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 185 ELEQQVNDMLLIAKGKQEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEGDSE--MQVNLHGLSSAINNLVINSLE 262
Cdd:PRK09959 763 GLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALK 842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 263 ---AGATRVILRL----SCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTT----KRQGTGLGLAVVQSVVRSHGGKLDLSC 331
Cdd:PRK09959 843 fttEGAVKITTSLghidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLES 922
|
250
....*....|....*....
gi 765521844 332 KLGAGCTVTLTFPLTTDSQ 350
Cdd:PRK09959 923 HPGIGTTFTITIPVEISQQ 941
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-344 |
3.62e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 62.30 E-value: 3.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLE--AGATRVILRLSCD-QTLRLDVIDNGKGLDSKMQKQVLEPFFTTK-----RQGTGLGLAVVQSVV 320
Cdd:cd16948 6 LSFIIGQIVSNALKysKQGGKIEIYSETNeQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 765521844 321 RSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
255-341 |
9.08e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 60.93 E-value: 9.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 255 NLVINSLEA------GATRVILRLSCDQtLRLDVIDNGKGLDSKMQKQVLEPFFTTKR--QGTGLGLAVVQSVVRSHGGK 326
Cdd:cd16976 7 NLLQNALDAmgkvenPRIRIAARRLGGR-LVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVEEHGGR 85
|
90
....*....|....*
gi 765521844 327 LDLSCKLGAGCTVTL 341
Cdd:cd16976 86 LSVANEEGAGARFTF 100
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-345 |
1.08e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 60.80 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGATRVILRLSCDQT-LRLDVIDNGKGLDSKMQKQVLEPFF------TTKRQGTGLGLAVVQSVVR 321
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDqWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 765521844 322 SHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-344 |
2.09e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 60.29 E-value: 2.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAG--ATRVILRLSCD-QTLRLDVIDNGKGLDSKMQKQVLEPFF------TTKRQGTGLGLAVVQSV 319
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEeSGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 765521844 320 VRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
33-330 |
3.24e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 63.56 E-value: 3.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 33 EHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTIINRA-----------FAPQKDDGHEVSLR-NGRR 97
Cdd:PRK11073 10 GQILNSLINSILLLDDDLAIHYANPAAQQLLAQSsrkLFGTPLPELLSYFslnielmreslQAGQGFTDNEVTLViDGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 98 VKLAIT--PLTpeqgQLIMLTDL----TETRLLQQNLSHLERLSAlGKMVATLAHQIRTPLS----AALLYAANLGSPRL 167
Cdd:PRK11073 90 HILSLTaqRLP----EGMILLEMapmdNQRRLSQEQLQHAQQVAA-RDLVRGLAHEIKNPLGglrgAAQLLSKALPDPAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 168 dagsRERFQGKL--LDRLSELEqqvnDMLLiakGKQEEAcDRVPFS--TVLEKVmancepiaaRQNVELSLQ----IEGD 239
Cdd:PRK11073 165 ----TEYTKVIIeqADRLRNLV----DRLL---GPQRPG-THVTESihKVAERV---------VQLVSLELPdnvrLIRD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 240 -----SEMQVNLHGLSSAINNLVINSLEA-----GATRVILRLSCDQTL---------RLDVIDNGKGLDSKMQKQVLEP 300
Cdd:PRK11073 224 ydpslPELAHDPDQIEQVLLNIVRNALQAlgpegGTITLRTRTAFQLTLhgeryrlaaRIDIEDNGPGIPPHLQDTLFYP 303
|
330 340 350
....*....|....*....|....*....|
gi 765521844 301 FFTTKRQGTGLGLAVVQSVVRSHGGKLDLS 330
Cdd:PRK11073 304 MVSGREGGTGLGLSIARNLIDQHSGKIEFT 333
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
142-330 |
3.65e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 64.02 E-value: 3.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 142 ATLAHQIRTPLSaallyaaNLGSPRLDAGSRERFQGKLLDRL-SELEQ------QVNDMLLIAKG-KQEEACDRVPFSTV 213
Cdd:PRK09835 267 ADIAHEIRTPIT-------NLITQTEIALSQSRSQKELEDVLySNLEEltrmakMVSDMLFLAQAdNNQLIPEKKMLDLA 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 214 LE--KVMANCEPIAARQNVELSL-----QIEGDSEMqvnlhgLSSAINNLVINSLE---AGaTRVILRLS-CDQTLRLDV 282
Cdd:PRK09835 340 DEvgKVFDFFEAWAEERGVELRFvgdpcQVAGDPLM------LRRAISNLLSNALRytpAG-EAITVRCQeVDHQVQLVV 412
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 765521844 283 IDNGKGLDSKMQKQVLEPFFTT------KRQGTGLGLAVVQSVVRSHGGKLDLS 330
Cdd:PRK09835 413 ENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVT 466
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
142-346 |
3.68e-11 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 64.66 E-value: 3.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 142 ATLAHQIRTPLSAALLYAANLGSPRLDAGsrerfQGKLLDR-----LSELEQqVNDML---LIAKGKQE---EACDRVPf 210
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQNTPLTAE-----QMDLADTarqctLSLLAI-INNLLdfsRIESGQMTlslEETALLP- 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 211 stVLEKVM------ANCEPIAAR----QNVELSLQIEGDSEMQ--VNLHGlssainnlviNSL---EAGatRVILRL-SC 274
Cdd:PRK15347 476 --LLDQAMltiqgpAQSKSLTLRtfvgAHVPLYLHLDSLRLRQilVNLLG----------NAVkftETG--GIRLRVkRH 541
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 765521844 275 DQTLRLDVIDNGKGLDSKMQKQVLEPFFTT--KRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLT 346
Cdd:PRK15347 542 EQQLCFTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
201-347 |
3.92e-11 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 63.78 E-value: 3.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 201 QEEACDRVPFSTVLEKVmancepIAARQNVELslQIE---GDSEMQVNLHGLS--SAINNLVINSLEAGATRVILRLSCD 275
Cdd:PRK09467 287 QEMPMEMADLNALLGEV------IAAESGYER--EIEtalQPGPIEVPMNPIAikRALANLVVNAARYGNGWIKVSSGTE 358
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 765521844 276 -QTLRLDVIDNGKGLDSKMQKQVLEPFFT--TKR--QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTT 347
Cdd:PRK09467 359 gKRAWFQVEDDGPGIPPEQLKHLFQPFTRgdSARgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
126-349 |
6.34e-11 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 63.41 E-value: 6.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 126 QNLSHLERL-SALGKMVATLAHQIRTPLS-----AALLyaanlgsprldagsRERF-QGKLLDRL----SELEQQVNDML 194
Cdd:PRK09470 231 QMVTALERMmTSQQRLLSDISHELRTPLTrlqlaTALL--------------RRRQgESKELERIeteaQRLDSMINDLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 195 LIAKG--KQEEACDRVPFSTVLEKVMANCEPIAARQNveLSLQIEGDSEMQV---NLHGLSSAINNLVINSLEAGATRVI 269
Cdd:PRK09470 297 VLSRNqqKNHLERETFKANSLWSEVLEDAKFEAEQMG--KSLTVSAPPGPWPingNPNALASALENIVRNALRYSHTKIE 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 270 LRLSCD-QTLRLDVIDNGKGLDSKMQKQVLEPFFTTK----RQ--GTGLGLAVVQSVVRSHGGKLDLS-CKLGaGCTVTL 341
Cdd:PRK09470 375 VAFSVDkDGLTITVDDDGPGVPEEEREQIFRPFYRVDeardREsgGTGLGLAIVENAIQQHRGWVKAEdSPLG-GLRLTI 453
|
....*...
gi 765521844 342 TFPLTTDS 349
Cdd:PRK09470 454 WLPLYKRS 461
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
144-348 |
1.32e-10 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 62.31 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 144 LAHQIRTPLSaallyaanlgsprldagsRERFQGKLLDRLSELEQQ------------VNDMLLIAKGKQEEA---CDRV 208
Cdd:PRK10604 219 IAHELRTPLV------------------RLRYRLEMSDNLSAAESQalnrdigqlealIEELLTYARLDRPQNelhLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 209 PFSTVLEKVMANCEPIAARQNVELSLQIEGDSeMQVNLHGLSSAINNLVINSLEAGATRVILRLSCDQ-TLRLDVIDNGK 287
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDY-GALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGnQACLIVEDDGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 765521844 288 GLDSKMQKQVLEPFF------TTKRQGTGLGLAVVQSVVRSHGGKLDL-SCKLGaGCTVTLTFPLTTD 348
Cdd:PRK10604 360 GIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCdESELG-GARFSFSWPVWHN 426
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
88-344 |
1.40e-10 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 61.89 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 88 HEVSLRNGRRVKLAITPLTPEQ--GQLIMLTDltET-RLLQQNLSHLERLSALGKMVATLAHQIRTPLSAALLYAANLGS 164
Cdd:PRK09303 101 QEGATYSGLGENLQPSEIDSGRysQELLQLSD--ELfVLRQENETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLEL 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 165 PRLDAGS------RERFQGKLLDRLSELEQQVNDMLLIAKGKQEEAC---DRVPFSTVLEKVMANCEPIAARQNVELSLQ 235
Cdd:PRK09303 179 GQIDEDTelkpalIEQLQDQARRQLEEIERLITDLLEVGRTRWEALRfnpQKLDLGSLCQEVILELEKRWLAKSLEIQTD 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 236 IE-------GDSE--MQVnlhglssaINNLVINSL----EAGATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFF 302
Cdd:PRK09303 259 IPsdlpsvyADQEriRQV--------LLNLLDNAIkytpEGGTITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRV 330
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 765521844 303 TTKR----QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:PRK09303 331 RLPRdegtEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
201-350 |
1.75e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 61.84 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 201 QEEACDRVPFSTVLEKVMANCEPIAARQNVELSLQIEG---DSEMQVNLhGLssAINNLVINSLEAGAT-----RVILRL 272
Cdd:COG3920 352 QSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDvelPADAAVPL-GL--ILNELVTNALKHAFLsgeggRIRVSW 428
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 765521844 273 SC-DQTLRLDVIDNGKGLDSKMqkqvlepfftTKRQGTGLGLAVVQSVVRSHGGKLDLSckLGAGCTVTLTFPLTTDSQ 350
Cdd:COG3920 429 RReDGRLRLTVSDNGVGLPEDV----------DPPARKGLGLRLIRALVRQLGGTLELD--RPEGTRVRITFPLAELAA 495
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-344 |
2.73e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 57.09 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGATRVILRLSC---DQTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQ------GTGLGLAVVQSV 319
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAaqtPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 765521844 320 VRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
141-345 |
3.86e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 61.46 E-value: 3.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 141 VATLAHQIRTPLSAALLYAANLGSPRLDAGSRERFQGkLLDRLSELEQQVNDML---LIAKGKQEEACDRVPFS--TVLE 215
Cdd:PRK11466 448 LAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRA-ITDSGESLLTILNDILdysAIEAGGKNVSVSDEPFEprPLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 216 KVMANCEpiAARQNVELSLQIEGDSEMQVNLHGLSSAINNLVINSLEAGAT-----RVILRLSCDQT-LRLDVIDNGKGL 289
Cdd:PRK11466 527 STLQLMS--GRVKGRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALRftdegSIVLRSRTDGEqWLVEVEDSGCGI 604
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 765521844 290 DSKMQKQVLEPF--FTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:PRK11466 605 DPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
152-348 |
4.00e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 59.63 E-value: 4.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 152 LSAALLYAANLGspRLDAGSRERFQGKLLDRLSELEQQVNDMLLIAKGKQEEACDRVPFSTVLEKVmanCEPIAARQNVE 231
Cdd:COG4585 69 LSAIKLQLEAAR--RLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEEL---AERLLRAAGIR 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 232 LSLQIEG-----DSEMQVNLHglsSAINNLVINSLE-AGATRVILRLSC-DQTLRLDVIDNGKGLDskmqkqvlepffTT 304
Cdd:COG4585 144 VELDVDGdpdrlPPEVELALY---RIVQEALTNALKhAGATRVTVTLEVdDGELTLTVRDDGVGFD------------PE 208
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 765521844 305 KRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTTD 348
Cdd:COG4585 209 AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
233-343 |
4.75e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 56.26 E-value: 4.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 233 SLQIEGDSEMqvnlhgLSSAINNLVINSLE---AGaTRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFF---TTKR 306
Cdd:cd16940 4 DIQVQGDALL------LFLLLRNLVDNAVRyspQG-SRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNY 76
|
90 100 110
....*....|....*....|....*....|....*..
gi 765521844 307 QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTF 343
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
100-347 |
8.76e-10 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 60.05 E-value: 8.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 100 LAITP------LTPEQGQLI---------MLTDLTETRLLQQNLSHLERLSALGKMVATLAHQIRTPLSA----ALLYAA 160
Cdd:PRK10490 612 LAVEPgnlrqlMIPEQQRLLetftllianALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVlfgqAEILTL 691
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 161 NLGSprldAGSRERFQGklldrlSELEQQ-------VNDMLLIAKGKQEEACDRVPFSTVLEKV---MANCEPIAARQNV 230
Cdd:PRK10490 692 DLAS----EGSPHARQA------SEIRQQvlnttrlVNNLLDMARIQSGGFNLRKEWLTLEEVVgsaLQMLEPGLSGHPI 761
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 231 ELSLQiegdSEMQVnLHGLSSAINNLVINSLE-----AGA-TRVILRLSC-DQTLRLDVIDNGKGLDSKMQKQVLEPFFT 303
Cdd:PRK10490 762 NLSLP----EPLTL-IHVDGPLFERVLINLLEnavkyAGAqAEIGIDAHVeGERLQLDVWDNGPGIPPGQEQLIFDKFAR 836
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 765521844 304 TKRQ----GTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTT 347
Cdd:PRK10490 837 GNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLET 884
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-336 |
2.33e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 53.99 E-value: 2.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGATRVILRLSCDQT-LRLDVIDNGKGLDSKMQKQVLEPFFTTKR----QGTGLGLAVVQSVVRSH 323
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNrTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISDAH 80
|
90
....*....|...
gi 765521844 324 GGKLDLSCKLGAG 336
Cdd:cd16950 81 GGSLTLANRAGGG 93
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-345 |
2.47e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 53.97 E-value: 2.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGATRV-ILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFF------TTKRQGTGLGLAVVQSVVR 321
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVrIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....*
gi 765521844 322 SHGGKLDL-SCKLGAGCtVTLTFPL 345
Cdd:cd16939 81 WHGGHVECdDSELGGAC-FRLTWPR 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-332 |
6.22e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 53.67 E-value: 6.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 243 QVNLHGLSSAINNLVINSLEAGATRVIL--RLSCDQT-LRLDVIDNGKGLDSKMQKQVLEPFFT------TKRQGTGLGL 313
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLgmTLREDEKhVYIDIWDKGKGISETEKDHVFERLYTledsrnSAKQGNGLGL 94
|
90
....*....|....*....
gi 765521844 314 AVVQSVVRSHGGKLDLSCK 332
Cdd:cd16947 95 TITKRLAESMGGSIYVNSK 113
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
279-344 |
6.66e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.10 E-value: 6.66e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 765521844 279 RLDVIDNGKGLDSKMQKQVLEPFfttKR-------QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16921 36 TFYVRDNGIGIDPEYAEKVFGIF---QRlhsreeyEGTGVGLAIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-344 |
6.95e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 52.67 E-value: 6.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGA------TRVILRLSCD-QTLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQGT-GLGLAVVQSVV 320
Cdd:cd16915 1 LITIVGNLIDNALDALAatgapnKQVEVFLRDEgDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSV 80
|
90 100
....*....|....*....|....
gi 765521844 321 RSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
142-353 |
7.12e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 56.95 E-value: 7.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 142 ATLAHQIRTPLsAAL---LYAANLGSPRLDAGSRERFQG------KLLDRLSELEQqvNDMLLIAKgkQEEACDRVPfst 212
Cdd:PRK10549 245 ADISHELRTPL-AVLrgeLEAIQDGVRKFTPESVASLQAevgtltKLVDDLHQLSL--SDEGALAY--RKTPVDLVP--- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 213 VLEKVMANC-EPIAARQnvelsLQIEGDSEMQVNLHG----LSSAINNLVINSL---EAGATRVILRLSCDQTLRLDVID 284
Cdd:PRK10549 317 LLEVAGGAFrERFASRG-----LTLQLSLPDSATVFGdpdrLMQLFNNLLENSLrytDSGGSLHISAEQRDKTLRLTFAD 391
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 765521844 285 NGKGLDSKMQKQVLEPFFTTKRQ------GTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLTTDSQGGV 353
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 466
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
136-202 |
8.65e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.44 E-value: 8.65e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 765521844 136 ALGKMVATLAHQIRTPLSAALLYAANLGSPRLDAGSRERFQgKLLDRLSELEQQVNDMLLIAKGKQE 202
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLE-TILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
136-202 |
2.62e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.87 E-value: 2.62e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 765521844 136 ALGKMVATLAHQIRTPLSAALLYAANLGSPRLDAGSRERFQgKLLDRLSELEQQVNDMLLIAKGKQE 202
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLE-TILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
134-198 |
4.42e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 49.52 E-value: 4.42e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 765521844 134 LSALGKMVATLAHQIRTPLSAALLYAANLGSPRLDAGSRERFQGKLLDRLSELEQQVNDMLLIAK 198
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
209-345 |
5.61e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 54.47 E-value: 5.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 209 PFS--TVLEKVMANCEPIAARQNVELSLQIegDSEMQVNLHG----LSSAINNLVINSL---EAGAT--RVILRLSCDQ- 276
Cdd:PRK11107 365 PFSlrETLDEVVTLLAHSAHEKGLELTLNI--DPDVPDNVIGdplrLQQIITNLVGNAIkftESGNIdiLVELRALSNTk 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 277 -TLRLDVIDNGKGLDSKMQKQVLEPFfttkRQ----------GTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:PRK11107 443 vQLEVQIRDTGIGISERQQSQLFQAF----RQadasisrrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
253-344 |
9.71e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 49.80 E-value: 9.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 253 INNLVINSLEA----GATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPF------FTTKRQGTGLGLAVVQSVVRS 322
Cdd:cd16925 9 VLNLLSNAFKFtpdgGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLSIVKEFVEL 88
|
90 100
....*....|....*....|..
gi 765521844 323 HGGKLDLSCKLGAGCTVTLTFP 344
Cdd:cd16925 89 HGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
142-345 |
9.91e-08 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.82 E-value: 9.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 142 ATLAHQIRTPLSAALlyaanlgsprldaGSRERFQGKLL----DRL--------SELEQQVNDMLLIAKGKQEE-ACDRV 208
Cdd:PRK10841 452 ATVSHELRTPLYGII-------------GNLDLLQTKELpkgvDRLvtamnnssSLLLKIISDILDFSKIESEQlKIEPR 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 209 PFST--VLEKVMANCEPIAARQNVELSLQIEGDseMQVNLHG----LSSAINNLVINSLEAGATR-VILRLSCDQT-LRL 280
Cdd:PRK10841 519 EFSPreVINHITANYLPLVVKKRLGLYCFIEPD--VPVALNGdpmrLQQVISNLLSNAIKFTDTGcIVLHVRVDGDyLSF 596
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 765521844 281 DVIDNGKGLDSKMQKQVLEPFFT----TKR--QGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPL 345
Cdd:PRK10841 597 RVRDTGVGIPAKEVVRLFDPFFQvgtgVQRnfQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-329 |
1.08e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 49.38 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSL----EAGATRVILRLSCDQtLRLDVIDNGKGLDSKMQKQVLEPFFT-----TKRQGTGLGLAVVQSV 319
Cdd:cd16945 5 LRQAINNLLDNAIdfspEGGLIALQLEADTEG-IELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEV 83
|
90
....*....|
gi 765521844 320 VRSHGGKLDL 329
Cdd:cd16945 84 AQLHGGRITL 93
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
225-344 |
2.74e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 52.22 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 225 AARQNVELSLQIEG-----DSEMQVnlHGLSSAINNLVINSLEA------GATRVILRLScDQTLRLDVIDNGKGLDSKM 293
Cdd:PRK11086 407 ARELGITLIISEDSqlpdsGDEDQV--HELITILGNLIENALEAvggeegGEISVSLHYR-NGWLHCEVSDDGPGIAPDE 483
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 765521844 294 QKQVLEPFFTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFP 344
Cdd:PRK11086 484 IDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-343 |
2.90e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.23 E-value: 2.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 249 LSSAINNLVINSLEAGATRVILRLS--CDQT-LRLDVIDNGKGLDSKMQKQVLEPFFT-----TKRQGTGLGLAVVQSVV 320
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISiyDEEEyLYFEIWDNGHGFSEQDLKKALELFYRddtsrRSGGHYGMGLYIAKNLV 84
|
90 100
....*....|....*....|...
gi 765521844 321 RSHGGKLDLSCKLGAGCTVTLTF 343
Cdd:cd16975 85 EKHGGSLIIENSQKGGAEVTVKI 107
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
166-346 |
5.15e-07 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 51.34 E-value: 5.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 166 RLDAGSRERFQGKLLDRLSELEQQVNDMlliakgkQEEACD-R-VPFSTVLEKVmanceP-----IAARQNVELSLQIEG 238
Cdd:COG0643 198 QLAEELEDESLRELEEALEQLSRLTREL-------QDGVMRlRmVPISTVFNRF-----PrmvrdLARELGKEVELVIEG 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 239 -DSEM--QVnLHGLSSAINNLVINS----LEAGATRV--------ILRLSCDQT---LRLDVIDNGKGLD---------- 290
Cdd:COG0643 266 eETELdrTV-LERLGDPLVHLVRNAvdhgIETPEERLaagkpetgTITLSAYHEggrVVIEVSDDGRGLDlekirakaie 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 765521844 291 ---------SKM-QKQVL----EPFFTTKRQ-----GTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTFPLT 346
Cdd:COG0643 345 kglitaeeaAALsDEELLelifAPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPLT 419
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
31-83 |
3.30e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 44.31 E-value: 3.30e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 765521844 31 RMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTIINRAFAPQ 83
Cdd:smart00091 2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSpeeLIGKSLLELIHPEDRER 57
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
145-342 |
4.30e-06 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 48.11 E-value: 4.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 145 AHQIRTPLSAALLYA--ANLGSPrlDAGSRERFQGKL---LDRLSELEQQVNDMLLIAKGKQEEACDRVPFSTVLEKVMA 219
Cdd:PRK10337 245 AHELRSPLAALKVQTevAQLSDD--DPQARKKALLQLhagIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVM 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 220 NCEPIAARQNVELSLQIEGdseMQVNLHG----LSSAINNLVINSLE---AGATrVILRLSCDqtlRLDVIDNGKGLDSK 292
Cdd:PRK10337 323 DIYHTAQQAGIDVRLTLNA---HPVIRTGqpllLSLLVRNLLDNAIRyspQGSV-VDVTLNAR---NFTVRDNGPGVTPE 395
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 765521844 293 MQKQVLEPFFTTKRQ---GTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLT 342
Cdd:PRK10337 396 ALARIGERFYRPPGQeatGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
275-348 |
8.86e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 47.32 E-value: 8.86e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 765521844 275 DQTLRLDVIDNGKGLDSKMQKQVLEPfFTTKRQGTGLGLAVVQSVVRSHGGK---LDLSCKLGAGCTVTLTFPLTTD 348
Cdd:COG2972 370 GDRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
30-99 |
1.12e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 43.95 E-value: 1.12e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 765521844 30 NRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQrwltIINRAFAPQKDDGHEVSLRNGRRVK 99
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSreeVIGK----SLLDLIPEEDDAEVAELLRQALLQG 69
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
23-139 |
1.13e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 47.07 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 23 REAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTIIN-----RAFAPQKDDGHEVSLRN 94
Cdd:COG3829 4 LELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPreeVIGKNVTELIPnspllEVLKTGKPVTGVIQKTG 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 765521844 95 GRRVKLAITpLTP--EQGQLI----MLTDLTETRLLQQNLSHLERLSALGK 139
Cdd:COG3829 84 GKGKTVIVT-AIPifEDGEVIgaveTFRDITELKRLERKLREEELERGLSA 133
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
224-344 |
1.27e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 45.27 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 224 IAARQNVELSLQIEG-DSEMQVN-LHGLSSAINNLVINS----LEAGATR----------VILR--LSCDQTLrLDVIDN 285
Cdd:cd16916 12 LARELGKQVELVVEGeDTELDKSvLEKLADPLTHLLRNAvdhgIEAPEERlaagkppegtITLRaeHQGNQVV-IEVSDD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 286 GKGLDSKMQKQ------------------------VLEPFFTTKRQ-----GTGLGLAVVQSVVRSHGGKLDLSCKLGAG 336
Cdd:cd16916 91 GRGIDREKIREkaierglitadeaatlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQG 170
|
....*...
gi 765521844 337 CTVTLTFP 344
Cdd:cd16916 171 TTFTIRLP 178
|
|
| mutl |
TIGR00585 |
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ... |
246-305 |
1.54e-05 |
|
DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273155 [Multi-domain] Cd Length: 312 Bit Score: 46.09 E-value: 1.54e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 246 LHGLSSAINNLVINSLEAGATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTK 305
Cdd:TIGR00585 20 IERPASVVKELVENSLDAGATRIDVEIEEGGLKLIEVSDNGSGIDKEDLPLACERHATSK 79
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
114-350 |
1.60e-05 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 46.11 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 114 MLTDLTETrlLQQnlshlERLSAlgkmvATLAHQIRTPLSAALLY---AANLGSPRLDAgsrerfqgkLLDRLSELEQQV 190
Cdd:PRK10755 126 LVSRLTST--LDQ-----ERLFT-----ADVAHELRTPLAGIRLHlelLEKQHHIDVAP---------LIARLDQMMHTV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 191 NDMLLIAKGKQEEAC---DRVPF--STVLEKVMANCEPIAARQnVELSLQiegDSEMQVNLHG----LSSAINNLVINS- 260
Cdd:PRK10755 185 EQLLQLARAGQSFSSghyQTVKLleDVILPSQDELSEMLEQRQ-QTLLLP---ESAADITVQGdatlLRLLLRNLVENAh 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 261 -LEAGATRVILRLSCDQT-LRLDVIDNGKGLDSKMQKQVLEPF--FTTKRQGTGLGLAVVQSVVRSHGGKLDLSCKL-GA 335
Cdd:PRK10755 261 rYSPEGSTITIKLSQEDGgAVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRS 340
|
250
....*....|....*
gi 765521844 336 GCTVTLTFPLTTDSQ 350
Cdd:PRK10755 341 GTRAWVWLPKAQNVA 355
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
30-90 |
2.61e-05 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 41.77 E-value: 2.61e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 765521844 30 NRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVPLVGQRWLTIINRAFAPQKDDGHEV 90
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELL 61
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
263-344 |
3.24e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.77 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 263 AGATRVILRLSCDQT-LRLDVIDNGKGLDSKmqkqvlepfftTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTL 341
Cdd:cd16917 16 AGASRVRVTLSYTADeLTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTA 84
|
...
gi 765521844 342 TFP 344
Cdd:cd16917 85 RLP 87
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
224-343 |
3.59e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 43.00 E-value: 3.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 224 IAARQNVELSLQIEGDSEMQVNLHGLSSAINNLVINSLEAGATRVILRLS-CDQTLRLDVIDNGKG-LDSKMQK-----Q 296
Cdd:cd16954 13 VYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARqTDGGLHLIVDDDGPGvPESQRSKifqrgQ 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 765521844 297 VLEpfftTKRQGTGLGLAVVQSVVRSHGGKLDLSCKLGAGCTVTLTF 343
Cdd:cd16954 93 RLD----EQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
23-133 |
1.26e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 43.09 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 23 REAANMSNRMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTI------------INRAFAPQKDDG 87
Cdd:COG2202 4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSaeeLLGKTLRDLlppedddeflelLRAALAGGGVWR 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 765521844 88 HEVSLR--NGRR--VKLAITPLTPEQGQLI----MLTDLTETRLLQQNLSHLER 133
Cdd:COG2202 84 GELRNRrkDGSLfwVELSISPVRDEDGEITgfvgIARDITERKRAEEALRESEE 137
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
268-345 |
3.52e-04 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 42.62 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 268 VILRLSCDQ--TLRLDVIDNGKGLDSKMQKQVLEPFFTTKRQ-------GTGLGLAVVQSVVRSHGGKLDLSCKLGAGCT 338
Cdd:PRK11091 419 VTVRVRYEEgdMLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSC 498
|
....*..
gi 765521844 339 VTLTFPL 345
Cdd:PRK11091 499 FTLTIHA 505
|
|
| HATPase_MutL-MLH-PMS-like |
cd16926 |
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ... |
249-305 |
3.80e-04 |
|
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.
Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 40.88 E-value: 3.80e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 765521844 249 LSSAINNLVINSLEAGATRVILRLSCDQTLRLDVIDNGKGLDSKMQKQVLEPFFTTK 305
Cdd:cd16926 14 PASVVKELVENSIDAGATRIDVEIEEGGLKLIRVTDNGSGISREDLELAFERHATSK 70
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
39-119 |
5.40e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 38.77 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 39 MPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTIINRAFAPQKDDGHEVSLRNGRRVKLAITPLTPEQGQLIML 115
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSpeeLIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80
|
....
gi 765521844 116 TDLT 119
Cdd:cd00130 81 VSLT 84
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
263-351 |
3.31e-03 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 39.22 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 263 AGATRVILRLSCD-QTLRLDVIDNGKGLDSKMQKqvlepffttkrqgTGLGLAVVQSVVRSHGGKLDLSC-KLGAGCTVT 340
Cdd:COG3851 416 AEASQIRISLSQDkRLLSLEIRDDGIGLPPELRA-------------KGFGLRGMRERVRALGGDFRLSSaPKGTRLSVL 482
|
90
....*....|.
gi 765521844 341 LTFPLTTDSQG 351
Cdd:COG3851 483 LPTPAASNEAG 493
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
31-128 |
3.91e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 38.47 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 31 RMEHILQAMPSGVVILNGDGLVSEANPVAESLLGVP---LVGQRWLTIIN-----------RAFAPQKDDGHEVSLR--- 93
Cdd:COG2202 138 RLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSpeeLLGKSLLDLLHpedrerllellRRLLEGGRESYELELRlkd 217
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 765521844 94 -NGRRVKLAITPLTPEQGQ-----LIMLTDLTETRLLQQNL 128
Cdd:COG2202 218 gDGRWVWVEASAVPLRDGGevigvLGIVRDITERKRAEEAL 258
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
252-341 |
5.02e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 38.81 E-value: 5.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765521844 252 AINNLVINsleAGATRVILRLSC-DQTLRLDVIDNGKGLDskmqkqvlepfftTKRQGTGLGLAVVQSVVRSHGGKLDLS 330
Cdd:PRK11644 418 GLNNIVKH---ADASAVTLQGWQqDERLMLVIEDDGSGLP-------------PGSGQQGFGLRGMRERVTALGGTLTIS 481
|
90
....*....|.
gi 765521844 331 CKLGAGCTVTL 341
Cdd:PRK11644 482 CTHGTRLSVSL 492
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-344 |
5.82e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 35.88 E-value: 5.82e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 765521844 272 LSCDQTLRLDVIDNGKGLDSKmqkqVLEPFFTTKRQGTGLGLAVVQSVVRSHGGK---LDLSCKLGAGCTVTLTFP 344
Cdd:cd16924 32 LKEDNHVMIEVEDNGRGIDPK----VLNILGKKPKEGNGIGLYNVHQRLILLFGEdygIHIASEPDKGTRITFTIP 103
|
|
| |
