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Conserved domains on  [gi|765523711|ref|WP_044735946|]
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MULTISPECIES: curlin [Shewanella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
csgB super family cl32464
curlin minor subunit CsgB; Provisional
 41-98 2.41e-07

curlin minor subunit CsgB; Provisional


The actual alignment was detected with superfamily member PRK10101:

Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 46.78  E-value: 2.41e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 765523711  41 QQGSFNQAIIVQAGIDNSAILTQAGFGNQAQVVQLGVNNQVEMMQVGDANKANITQIG 98
Cdd:PRK10101  73 QEGSSNRAKIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYG 130
 
Name Accession Description Interval E-value
csgB PRK10101
curlin minor subunit CsgB; Provisional
 41-98 2.41e-07

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 46.78  E-value: 2.41e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 765523711  41 QQGSFNQAIIVQAGIDNSAILTQAGFGNQAQVVQLGVNNQVEMMQVGDANKANITQIG 98
Cdd:PRK10101  73 QEGSSNRAKIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYG 130
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
 32-65 6.78e-06

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 40.14  E-value: 6.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 765523711   32 GRDNLVDLMQQGSFNQAIIVQAGIDNSAILTQAG 65
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
 
Name Accession Description Interval E-value
csgB PRK10101
curlin minor subunit CsgB; Provisional
 41-98 2.41e-07

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 46.78  E-value: 2.41e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 765523711  41 QQGSFNQAIIVQAGIDNSAILTQAGFGNQAQVVQLGVNNQVEMMQVGDANKANITQIG 98
Cdd:PRK10101  73 QEGSSNRAKIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYG 130
csgB PRK10101
curlin minor subunit CsgB; Provisional
 37-112 7.43e-07

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 45.24  E-value: 7.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765523711  37 VDLMQQGSFNQA-IIVQAGIDNSA-----------ILTQAGFGNQAQVVQLGVNNQVEMMQVGDANKANITQIGNDNLVQ 104
Cdd:PRK10101  35 VNELSKSSFNQAaIIGQAGTNNSAqvrqggskllaVVSQEGSSNRAKIDQTGDYNLAYIDQTGSANDASISQGAYGNTAM 114


                 ....*...
gi 765523711 105 LNQLGSAN 112
Cdd:PRK10101 115 IIQKGSGN 122
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
 32-65 6.78e-06

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 40.14  E-value: 6.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 765523711   32 GRDNLVDLMQQGSFNQAIIVQAGIDNSAILTQAG 65
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
csgB PRK10101
curlin minor subunit CsgB; Provisional
 28-76 2.88e-04

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 38.30  E-value: 2.88e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 765523711  28 LETQGRDNLVDLMQQGSFNQAIIVQAGIDNSAILTQAGFGNQAQVVQLG 76
Cdd:PRK10101  82 IDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYG 130
csgA PRK10051
major curlin subunit CsgA;
28-112 6.97e-04

major curlin subunit CsgA;


Pssm-ID: 182211 [Multi-domain]  Cd Length: 151  Bit Score: 37.14  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765523711  28 LETQGRDNLVDLMQQGSFNQAIIVQAGIDNSAILTQAGFGNQAQVVQL-GVNNQVEMMQVGDANKANITQIGNDNLVQLN 106
Cdd:PRK10051  59 LQSDARNSDLTITQHGGGNGADVGQGSDDSSIDLTQNGFGNSATLDQWnGKNSDMTVKQFGGGNGAAVDQTASNSSVNVT 138


                 ....*.
gi 765523711 107 QLGSAN 112
Cdd:PRK10051 139 QVGFGN 144
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
 76-109 1.39e-03

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 33.98  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 765523711   76 GVNNQVEMMQVGDANKANITQIGNDNLVQLNQLG 109
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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