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Conserved domains on  [gi|766785579|ref|WP_044848383|]
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MULTISPECIES: helix-turn-helix domain-containing protein [unclassified Burkholderia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10130 super family cl26954
HTH-type transcriptional regulator EutR;
9-337 6.28e-78

HTH-type transcriptional regulator EutR;


The actual alignment was detected with superfamily member PRK10130:

Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 242.52  E-value: 6.28e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579   9 AEPTAEDTRCSAQGDDALAGQAVVSvahDADEQARNLIGWRQTYDQLAAGRFVGTLTELPLDTMKLFRESTSHLLRQACE 88
Cdd:PRK10130  14 HEPLPENLKLTPKVEVDNVHQRQTT---DVYEHALTITAWQQIYDQLHPGKFHGEFTEILLDDIQVFREYTGLALRQSCL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  89 VRGDAYWFGIPLTSDGTARVDACRIGPGALAFRPGNVEFELLTPAQFSIYGVVVRGDVLRRYAEEVEHRALDERLFAQR- 167
Cdd:PRK10130  91 VWPNSFWFGIPATRGEQGFIGSQCLGSAEIATRPGGTEFELSTPDDYTILGVVISEDVITRQANFLHNPERVLHMLRNQs 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 168 VIQIGDMRLarlcALLGGRLDGAAAAGGPLPD-----AQRDDLQAEVLAAL--FDACAQPADDGAGGAPSTRRWIVEQAR 240
Cdd:PRK10130 171 ALEVKEQHK----AALWGFVQQALATFCENPEnlhqpAVRKVLGDNLLMAMgaMLEEAQPMVTAESISHQSYRRLLSRAR 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 241 EYVLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAGS--VQDVAEAWGFWHLSQF 318
Cdd:PRK10130 247 EYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSttVKDAAMQWGFWHLGQF 326

                        330
                 ....*....|....*....
gi 766785579 319 ATDYRRLFGKRPSETLRER 337
Cdd:PRK10130 327 ATDYQQLFAEKPSLTLHQR 345
 
Name Accession Description Interval E-value
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
9-337 6.28e-78

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 242.52  E-value: 6.28e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579   9 AEPTAEDTRCSAQGDDALAGQAVVSvahDADEQARNLIGWRQTYDQLAAGRFVGTLTELPLDTMKLFRESTSHLLRQACE 88
Cdd:PRK10130  14 HEPLPENLKLTPKVEVDNVHQRQTT---DVYEHALTITAWQQIYDQLHPGKFHGEFTEILLDDIQVFREYTGLALRQSCL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  89 VRGDAYWFGIPLTSDGTARVDACRIGPGALAFRPGNVEFELLTPAQFSIYGVVVRGDVLRRYAEEVEHRALDERLFAQR- 167
Cdd:PRK10130  91 VWPNSFWFGIPATRGEQGFIGSQCLGSAEIATRPGGTEFELSTPDDYTILGVVISEDVITRQANFLHNPERVLHMLRNQs 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 168 VIQIGDMRLarlcALLGGRLDGAAAAGGPLPD-----AQRDDLQAEVLAAL--FDACAQPADDGAGGAPSTRRWIVEQAR 240
Cdd:PRK10130 171 ALEVKEQHK----AALWGFVQQALATFCENPEnlhqpAVRKVLGDNLLMAMgaMLEEAQPMVTAESISHQSYRRLLSRAR 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 241 EYVLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAGS--VQDVAEAWGFWHLSQF 318
Cdd:PRK10130 247 EYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSttVKDAAMQWGFWHLGQF 326

                        330
                 ....*....|....*....
gi 766785579 319 ATDYRRLFGKRPSETLRER 337
Cdd:PRK10130 327 ATDYQQLFAEKPSLTLHQR 345
HTH_18 pfam12833
Helix-turn-helix domain;
256-335 3.20e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 91.50  E-value: 3.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  256 LCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKRPSETLR 335
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
250-334 1.93e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 1.93e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579   250 PVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCgRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKR 329
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLR-DTDLSVTEIALRVGFSSQSYFSRAFKKLFGVT 79


                   ....*
gi 766785579   330 PSETL 334
Cdd:smart00342  80 PSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
95-338 5.99e-18

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 82.14  E-value: 5.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  95 WFGIPLTSDGTARVDACRIGPGALAFRPGNVEFELLTPAQFSIYGVVVRGDVLRRYAEEVEHRALDERLFAQRVIQIGDM 174
Cdd:COG2207   13 LLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 175 RLARLCALLGGRLDGAAAAGGPLPDAQRDDLQAEVLAALFDACAQPADDGAGGAPSTRRWIVEQAREYVLAHRTRPVGVP 254
Cdd:COG2207   93 GLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 255 ELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCgRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKRPSETL 334
Cdd:COG2207  173 ELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLA-ETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251


                 ....
gi 766785579 335 RERA 338
Cdd:COG2207  252 KRLR 255
 
Name Accession Description Interval E-value
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
9-337 6.28e-78

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 242.52  E-value: 6.28e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579   9 AEPTAEDTRCSAQGDDALAGQAVVSvahDADEQARNLIGWRQTYDQLAAGRFVGTLTELPLDTMKLFRESTSHLLRQACE 88
Cdd:PRK10130  14 HEPLPENLKLTPKVEVDNVHQRQTT---DVYEHALTITAWQQIYDQLHPGKFHGEFTEILLDDIQVFREYTGLALRQSCL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  89 VRGDAYWFGIPLTSDGTARVDACRIGPGALAFRPGNVEFELLTPAQFSIYGVVVRGDVLRRYAEEVEHRALDERLFAQR- 167
Cdd:PRK10130  91 VWPNSFWFGIPATRGEQGFIGSQCLGSAEIATRPGGTEFELSTPDDYTILGVVISEDVITRQANFLHNPERVLHMLRNQs 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 168 VIQIGDMRLarlcALLGGRLDGAAAAGGPLPD-----AQRDDLQAEVLAAL--FDACAQPADDGAGGAPSTRRWIVEQAR 240
Cdd:PRK10130 171 ALEVKEQHK----AALWGFVQQALATFCENPEnlhqpAVRKVLGDNLLMAMgaMLEEAQPMVTAESISHQSYRRLLSRAR 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 241 EYVLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAGS--VQDVAEAWGFWHLSQF 318
Cdd:PRK10130 247 EYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSttVKDAAMQWGFWHLGQF 326

                        330
                 ....*....|....*....
gi 766785579 319 ATDYRRLFGKRPSETLRER 337
Cdd:PRK10130 327 ATDYQQLFAEKPSLTLHQR 345
HTH_18 pfam12833
Helix-turn-helix domain;
256-335 3.20e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 91.50  E-value: 3.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  256 LCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKRPSETLR 335
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
250-334 1.93e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 1.93e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579   250 PVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCgRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKR 329
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLR-DTDLSVTEIALRVGFSSQSYFSRAFKKLFGVT 79


                   ....*
gi 766785579   330 PSETL 334
Cdd:smart00342  80 PSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
95-338 5.99e-18

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 82.14  E-value: 5.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579  95 WFGIPLTSDGTARVDACRIGPGALAFRPGNVEFELLTPAQFSIYGVVVRGDVLRRYAEEVEHRALDERLFAQRVIQIGDM 174
Cdd:COG2207   13 LLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 175 RLARLCALLGGRLDGAAAAGGPLPDAQRDDLQAEVLAALFDACAQPADDGAGGAPSTRRWIVEQAREYVLAHRTRPVGVP 254
Cdd:COG2207   93 GLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 255 ELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCgRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKRPSETL 334
Cdd:COG2207  173 ELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLA-ETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251


                 ....
gi 766785579 335 RERA 338
Cdd:COG2207  252 KRLR 255
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 227-343 4.76e-13

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 68.65  E-value: 4.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 227 GAPSTRRWIVEQAREYVLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAgSVQDV 306
Cdd:COG4977  203 VPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDL-SIEEI 281

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 766785579 307 AEAWGFWHLSQFATDYRRLFGKRPSEtLRERAVTVAA 343
Cdd:COG4977  282 AAACGFGSASHFRRAFRRRFGVSPSA-YRRRFRARAA 317
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 207-343 4.53e-11

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 63.15  E-value: 4.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 207 AEVLAALFDAC--AQPadDGAGGAPSTRRWiVEQAREYVLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLR 284
Cdd:COG2169   58 AAAEAAGFRPCkrCRP--DLAPGSPPRADL-VARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYAR 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 766785579 285 TLRLNGARRDLcgRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKRPSEtLRERAVTVAA 343
Cdd:COG2169  135 ARRLLRARQLL--QTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPSA-YRRGGAGAAI 190
ftrA PRK09393
transcriptional activator FtrA; Provisional
 241-331 2.99e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.58  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 241 EYVLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGArRDLCGRAAGSVQDVAEAWGFWHLSQFAT 320
Cdd:PRK09393 225 DWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARA-RDLLESSALSIDQIAERAGFGSEESLRH 303

                         90
                 ....*....|.
gi 766785579 321 DYRRLFGKRPS 331
Cdd:PRK09393 304 HFRRRAATSPA 314
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
254-332 1.27e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 46.21  E-value: 1.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766785579 254 PELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCgRAAGSVQDVAEAWGFWHLSQFATDYRRLFGKRPSE 332
Cdd:PRK13503 191 EALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLR-HSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRD 268
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 157-332 4.38e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 44.64  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 157 RALDERLF-AQRVIQIGDMRLARLCALLGGRLDGAAAAGGPLPDAQRDDLQaEVLAALFDACAQPADDGAGGAPSTRRwi 235
Cdd:PRK09685 124 RELVEQYFpGQKPACAGRLSASLPMVQLSHRLLQQSMNGPALSETESEALL-EALIALLRPALHQRESVQPRRERQFQ-- 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 236 veQAREYVLAHRTRPVGVPE-LCEQLHVSRRTLQYCFQDVlGMAPATYLRTLRLNGARRDLCGRAAG-SVQDVAEAWGFW 313
Cdd:PRK09685 201 --KVVALIDQSIQEEILRPEwIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRPAADDeKITSIAYKWGFS 277

                        170
                 ....*....|....*....
gi 766785579 314 HLSQFATDYRRLFGKRPSE 332
Cdd:PRK09685 278 DSSHFSTAFKQRFGVSPGE 296
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
243-339 6.82e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 41.04  E-value: 6.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766785579 243 VLAHRTRPVGVPELCEQLHVSRRTLQYCFQDVLGMAPATYLRTLRLNGARRDLCGRAAgSVQDVAEAWGFWHLSQFATDY 322
Cdd:PRK13501 185 LQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEH-RISDIAARCGFEDSNYFSAVF 263

                         90
                 ....*....|....*..
gi 766785579 323 RRLFGKRPSEtLRERAV 339
Cdd:PRK13501 264 TREAGMTPRD-YRQRFI 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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