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Conserved domains on  [gi|769928858|ref|WP_045063053|]
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transcriptional regulator UhpA [Photobacterium leiognathi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10360 super family cl32505
transcriptional regulator UhpA;
1-195 5.54e-99

transcriptional regulator UhpA;


The actual alignment was detected with superfamily member PRK10360:

Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 284.95  E-value: 5.54e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSGIACIMLSV 80
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAINLVSPNQNkqalgKLTKREHQISELLATGLDV 160
Cdd:PRK10360  81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQD-----PLTKRERQVAEKLAQGMAV 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 769928858 161 KAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAK 195
Cdd:PRK10360 156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDVELAR 190
 
Name Accession Description Interval E-value
PRK10360 PRK10360
transcriptional regulator UhpA;
1-195 5.54e-99

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 284.95  E-value: 5.54e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSGIACIMLSV 80
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAINLVSPNQNkqalgKLTKREHQISELLATGLDV 160
Cdd:PRK10360  81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQD-----PLTKRERQVAEKLAQGMAV 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 769928858 161 KAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAK 195
Cdd:PRK10360 156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDVELAR 190
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-116 1.26e-34

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 118.77  E-value: 1.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPS---GIACIMLSV 80
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRrypDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAA 116
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-195 1.35e-32

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 115.97  E-value: 1.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEpDMDVVGqFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIMLSV 80
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESA-GLRVET-FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELaarGSPLPVIFLTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 H-DSATVVEkALSLGAKGFLSKRCSPDELVQAVRTAAQggcyLTPDIAINLVSPNQNKQALGKLTKREHQISELLATGLD 159
Cdd:COG4566   80 HgDVPMAVR-AMKAGAVDFLEKPFDDQALLDAVRRALA----RDRARRAERARRAELRARLASLTPREREVLDLVVAGLS 154

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 769928858 160 VKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAK 195
Cdd:COG4566  155 NKQIARELGISPRTVEVHRANVMEKLGARSLAELVR 190
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-113 1.89e-24

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 92.60  E-value: 1.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858    4 VALVDDHIIVRSGFAQLLALEpDMdVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIMLSV 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKE-GY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIrrrDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 769928858   81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 143-197 2.83e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 69.48  E-value: 2.83e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 769928858   143 LTKREHQISELLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKFF 197
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 137-185 2.04e-03

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 37.33  E-value: 2.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 769928858  137 KQALGKLTKREHQISELLAT-GLDVKAVAVKLGLSHKTIHVHRANAMDKL 185
Cdd:TIGR02937 105 REALEKLPEREREVLVLRYLeGLSYKEIAEILGISVGTVKRRLKRARKKL 154
 
Name Accession Description Interval E-value
PRK10360 PRK10360
transcriptional regulator UhpA;
1-195 5.54e-99

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 284.95  E-value: 5.54e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSGIACIMLSV 80
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAINLVSPNQNkqalgKLTKREHQISELLATGLDV 160
Cdd:PRK10360  81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQD-----PLTKRERQVAEKLAQGMAV 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 769928858 161 KAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAK 195
Cdd:PRK10360 156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDVELAR 190
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-116 1.26e-34

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 118.77  E-value: 1.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPS---GIACIMLSV 80
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRrypDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAA 116
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-195 1.35e-32

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 115.97  E-value: 1.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEpDMDVVGqFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIMLSV 80
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESA-GLRVET-FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELaarGSPLPVIFLTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 H-DSATVVEkALSLGAKGFLSKRCSPDELVQAVRTAAQggcyLTPDIAINLVSPNQNKQALGKLTKREHQISELLATGLD 159
Cdd:COG4566   80 HgDVPMAVR-AMKAGAVDFLEKPFDDQALLDAVRRALA----RDRARRAERARRAELRARLASLTPREREVLDLVVAGLS 154

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 769928858 160 VKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAK 195
Cdd:COG4566  155 NKQIARELGISPRTVEVHRANVMEKLGARSLAELVR 190
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-194 1.96e-32

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 116.28  E-value: 1.96e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLL-----EDLPSGIacIML 78
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLdklreKSLSGRI--VVF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCY----LTPDIAINLVSPNQ-NKQALGKLTKREHQISEL 153
Cdd:PRK10651  87 SVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVlseaLTPVLAASLRANRAtTERDVNQLTPRERDILKL 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 769928858 154 LATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELA 194
Cdd:PRK10651 167 IAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAA 207
PRK09483 PRK09483
response regulator; Provisional
 1-193 8.73e-31

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 112.12  E-value: 8.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLS----LLEDLPsGIACI 76
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEatrkILRYTP-DVKII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  77 MLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDI----AINLVSPnQNKQALGKLTKREHQISE 152
Cdd:PRK09483  80 MLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIaqqmALSQIEP-ATENPFASLSERELQIML 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 769928858 153 LLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVEL 193
Cdd:PRK09483 159 MITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVEL 199
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-196 8.74e-31

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 109.21  E-value: 8.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLpsgiacimlsv 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 hdsatvvekalslgakgflskrcspdelvqavrtaaqggcyltpdiainlvspnqnkqalgkLTKREHQISELLATGLDV 160
Cdd:COG2197   70 --------------------------------------------------------------LTPREREVLRLLAEGLSN 87

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 769928858 161 KAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKF 196
Cdd:COG2197   88 KEIAERLGISERTVKTHVSNILRKLGVRNRTELVLL 123
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-191 3.92e-25

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 97.23  E-value: 3.92e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSGIAC---IMLS 79
Cdd:PRK10403   8 QVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTaqiIILT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  80 VHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAINLVSPNQNKQ---ALGKLTKREHQISELLAT 156
Cdd:PRK10403  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAeedPFSVLTERELDVLHELAQ 167

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 769928858 157 GLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNV 191
Cdd:PRK10403 168 GLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRV 202
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-113 1.89e-24

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 92.60  E-value: 1.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858    4 VALVDDHIIVRSGFAQLLALEpDMdVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIMLSV 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKE-GY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIrrrDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 769928858   81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK15369 PRK15369
two component system response regulator;
2-193 2.50e-22

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 89.75  E-value: 2.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPS---GIACIML 78
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQrwpAMNILVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTP----DIAINLVSPNQNKQALgkLTKREHQISELL 154
Cdd:PRK15369  84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPalnrEAILALLNADDTNPPL--LTPRERQILKLI 161

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 769928858 155 ATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVEL 193
Cdd:PRK15369 162 TEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAEL 200
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 2-198 4.23e-21

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 86.81  E-value: 4.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNE---SGLSLLEDLP---SGIAC 75
Cdd:PRK10840   4 MNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDkygDGITLIKYIKrhfPSLSI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  76 IMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAINLVSPNQNKQALGKLTKREHQISELLA 155
Cdd:PRK10840  84 IVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKRLSPKESEVLRLFA 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 769928858 156 TGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKFFS 198
Cdd:PRK10840 164 EGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLS 206
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-117 1.53e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 85.40  E-value: 1.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEpDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIM 77
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERA-GYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELralDPDLPVIL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALE 119
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-117 3.48e-19

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 79.63  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIM 77
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELrarGPDVDVIV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLE 122
fixJ PRK09390
response regulator FixJ; Provisional
 4-193 9.74e-19

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 80.05  E-value: 9.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEpDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLP---SGIACIMLSV 80
Cdd:PRK09390   6 VHVVDDDEAMRDSLAFLLDSA-GFEVR-LFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKargSPLPVIVMTG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 H-DSATVVEkALSLGAKGFLSKRCSPDELVQAVRTA------AQGGCYLTPDIAinlvspnqnkQALGKLTKREHQISEL 153
Cdd:PRK09390  84 HgDVPLAVE-AMKLGAVDFIEKPFEDERLIGAIERAlaqapeAAKSEAVAADIR----------ARIASLSERERQVMDG 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 769928858 154 LATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVEL 193
Cdd:PRK09390 153 LVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGSLSEL 192
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
4-196 2.17e-18

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 79.53  E-value: 2.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE---DLPSGIACIMLSV 80
Cdd:PRK09935   6 VIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKrikQIQSTVKVLFLSS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLtPDIAINLVS---PNQNKQALGKLTKREHQISELLATG 157
Cdd:PRK09935  86 KSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFF-PSETLNYIKsnkCSTNSSTDTVLSNREVTILRYLVSG 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 769928858 158 LDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKF 196
Cdd:PRK09935 165 LSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDY 203
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
6-196 2.40e-18

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 79.17  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   6 LVDDHIIVRSGFAQLLaLEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLP----SGIaCIMLSVH 81
Cdd:PRK09958   5 IIDDHPLAIAAIRNLL-IKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRkrqySGI-IIIVSAK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  82 DSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAINLVSPNQNKQALGKLTKREHQISELLATGLDVK 161
Cdd:PRK09958  83 NDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNN 162

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 769928858 162 AVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKF 196
Cdd:PRK09958 163 DIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTF 197
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-117 5.30e-18

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 75.85  E-value: 5.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLL-----EDLPSGIacIML 78
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLkalreEGVSARI--VIL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd19931   79 TVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAAS 117
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-114 1.31e-17

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 75.00  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL-PSGIAC--IMLSV 80
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELrEELPDTkvLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVRT 114
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRT 114
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-117 2.52e-16

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 71.75  E-value: 2.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEpDMDVVGqFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE-------DLPsgiaCI 76
Cdd:cd17549    1 VLLVDDDADVREALQQTLELA-GFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAqireldpDLP----VI 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769928858  77 MLSVH-DSATVVEkALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd17549   75 LITGHgDVPMAVE-AMRAGAYDFLEKPFDPERLLDVVRRALE 115
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 143-197 2.83e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 69.48  E-value: 2.83e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 769928858   143 LTKREHQISELLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKFF 197
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-101 3.21e-16

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 70.96  E-value: 3.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE---DLPSGIACIMLS 79
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEairELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|..
gi 769928858  80 VHDSATVVEKALSLGAKGFLSK 101
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLK 102
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-155 6.38e-16

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 72.68  E-value: 6.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEpDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIM 77
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALERE-GYEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLrarPSDIPIIM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGGCYLTPDIAiNLVSPNQNKQALG----KLTKREHQISEL 153
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLRVG-DLLDLAAREVTRDgepvELTPKEFRLLEL 157


                 ..
gi 769928858 154 LA 155
Cdd:COG0745  158 LM 159
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 6-117 1.16e-15

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 69.67  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   6 LVDDHIIVRSGFAQLLA-LEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE---DLPSGIACIMLSVH 81
Cdd:cd17536    3 IVDDEPLIREGLKKLIDwEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEkirELYPDIKIIILSGY 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 769928858  82 DSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd17536   83 DDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKE 118
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 3-117 2.34e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 71.35  E-value: 2.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSGFAQLLALEpDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL-----PSGIACIM 77
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTL-GYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLradpsTRDIPVIF 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALE 125
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 143-196 4.93e-15

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 66.40  E-value: 4.93e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 769928858 143 LTKREHQISELLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKF 196
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAY 54
GerE pfam00196
Bacterial regulatory proteins, luxR family;
143-194 1.36e-14

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 65.30  E-value: 1.36e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 769928858  143 LTKREHQISELLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELA 194
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-115 1.71e-14

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 69.46  E-value: 1.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSG---IACIM 77
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELdppPPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769928858  78 LSVHDSATVveKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:COG3279   81 TTAYDEYAL--EAFEVNAVDYLLKPIDEERLAKALEKA 116
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-101 5.60e-13

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 62.24  E-value: 5.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   6 LVDDHIIVRSGFAQLLalEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE---DLPSGIACIMLSVHD 82
Cdd:cd00156    2 IVDDDPAIRELLKSLL--EREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRklrELPPDIPVIVLTAKA 79

                         90
                 ....*....|....*....
gi 769928858  83 SATVVEKALSLGAKGFLSK 101
Cdd:cd00156   80 DEEDAVRALELGADDYLVK 98
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-115 6.56e-13

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 62.95  E-value: 6.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEpDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL-----PSGIAC 75
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIralprLPDIPI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 769928858  76 IMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-117 8.76e-13

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 65.56  E-value: 8.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL----PSGIacI 76
Cdd:PRK00742   3 KIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKImrlrPTPV--V 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 769928858  77 MLS--VHDSATVVEKALSLGAKGFLSKRCSP---------DELVQAVRTAAQ 117
Cdd:PRK00742  81 MVSslTERGAEITLRALELGAVDFVTKPFLGislgmdeykEELAEKVRAAAR 132
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 2-101 2.45e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 61.25  E-value: 2.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL----PsgIACIM 77
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRImaerP--TPVVM 78

                         90       100
                 ....*....|....*....|....*.
gi 769928858  78 LSVHDS--ATVVEKALSLGAKGFLSK 101
Cdd:cd17541   79 VSSLTEegAEITLEALELGAVDFIAK 104
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
142-197 2.52e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 62.85  E-value: 2.52e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 769928858 142 KLTKREHQISELLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELAKFF 197
Cdd:COG2771  127 GLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALA 182
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-119 3.04e-12

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 62.23  E-value: 3.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLAlEPDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL-----PSGIAC 75
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLE-AAGYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLradprTADIPI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 769928858  76 IMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQGG 119
Cdd:COG3706   79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVARYG 122
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-115 3.61e-12

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 62.28  E-value: 3.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLAlEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSGIAC--IML 78
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLR-EAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPApvILL 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:COG3707   82 TAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELA 118
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-115 1.41e-11

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 58.76  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLA---LEpdmdvVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIM 77
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRsvgLA-----VKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELlarGSNIPIIF 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 769928858  78 LSVH-DSATVVEkALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:cd17537   78 ITGHgDVPMAVE-AMKAGAVDFLEKPFRDQVLLDAIEQA 115
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 2-115 1.36e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 51.13  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLAlEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLED---LPSGIACIML 78
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILT-KAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEikkIDPNAKVIMC 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:cd17542   80 SAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-118 1.47e-08

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 52.88  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHiivRSgFAQLLA----LEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE-----DLPS 71
Cdd:COG5801    4 KIKVLIADDN---RE-FCELLEeylsSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGVLEklremNLEK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 769928858  72 GIACIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQG 118
Cdd:COG5801   80 RPKVIMLTAFGQEDITQRAVELGADYYILKPFDLDVLAERIRQLAGG 126
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-113 2.98e-08

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 51.07  E-value: 2.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   6 LVDDhiivRSGFAQLL--ALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL----PSgIACIMLS 79
Cdd:COG4567    9 LVDD----DEAFARVLarALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALrerdPD-ARIVVLT 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 769928858  80 VHDS-ATVVEkALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:COG4567   84 GYASiATAVE-AIKLGADDYLAKPADADDLLAALE 117
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-101 3.59e-08

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 49.94  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSG---IACIML 78
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAghdVDVIVV 80

                         90       100
                 ....*....|....*....|...
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSK 101
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIK 103
PRK11697 PRK11697
two-component system response regulator BtsR;
1-66 4.26e-08

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 51.39  E-value: 4.26e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLL 66
Cdd:PRK11697   1 MIKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELV 66
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 2-101 5.76e-08

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 49.14  E-value: 5.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSG-----IACI 76
Cdd:cd17561    2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMrlekrPKII 81

                         90       100
                 ....*....|....*....|....*
gi 769928858  77 MLSVHDSATVVEKALSLGAKGFLSK 101
Cdd:cd17561   82 MLTAFGQEDITQRAVELGASYYILK 106
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-117 1.24e-07

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 48.30  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   6 LVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL---PSGIACIMLSVHD 82
Cdd:cd17532    3 IVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLsklAKPPLIVFVTAYD 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 769928858  83 SATVveKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd17532   83 EYAV--EAFELNAVDYLLKPFSEERLAEALAKLRK 115
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 4-117 1.87e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 48.13  E-value: 1.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHiiVRSGFAQLLALEPDMDVVGQfSSAAEARAGLPGLDASVCILDISMPNESGLSLL----EDLPSGIACIMLS 79
Cdd:cd17596    3 ILVVDDE--VRSLEALRRTLEEDFDVLTA-ASAEEALAILEEEWVQVILCDQRMPGTTGVEFLkevrERWPEVVRIIISG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769928858  80 VHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd17596   80 YTDSEDIIAGINEAGIYQYLTKPWHPDQLLLTVRNAAR 117
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-101 3.02e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 47.44  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSGFAQLLALEPDMDVVGqFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE---DLPSG--IACIM 77
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVS-FTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRrlrALPGLedVPIVM 80

                         90       100
                 ....*....|....*....|....
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSK 101
Cdd:cd17551   81 ITADTDREVRLRALEAGATDFLTK 104
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-117 7.10e-07

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 48.34  E-value: 7.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL----PSGIACIM 77
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRImaerPCPILIVT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSK---------RCSPDELVQAVRTAAQ 117
Cdd:PRK12555  81 SLTERNASRVFEAMGAGALDAVDTptlgigaglEEYAAELLAKIDQIGR 129
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-115 1.34e-06

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 45.48  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLAlEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLS----LLEDLPSGIacIM 77
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLE-EAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEaakiITSENIAPI--VL 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769928858  78 LSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:cd19932   78 LTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMA 115
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 2-118 1.58e-06

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 45.48  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEPDMDVvgQF-SSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSG-----IAC 75
Cdd:cd17575    1 IMVLLVDDQAIIGEAVRRALADEEDIDF--HYcSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANpatrdIPI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769928858  76 IMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQG 118
Cdd:cd17575   79 IVLSTKEEPEVKSEAFALGANDYLVKLPDKIELVARIRYHSRS 121
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 3-111 1.61e-06

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 45.13  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIvrsgFAQLL--ALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL----PSgIACI 76
Cdd:cd17563    2 SLLLVDDDEV----FAERLarALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLralqPD-ARIV 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 769928858  77 MLSVHDS-ATVVEkALSLGAKGFLSKRCSPDELVQA 111
Cdd:cd17563   77 VLTGYASiATAVE-AIKLGADDYLAKPADADEILAA 111
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 52-108 4.05e-06

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 44.16  E-value: 4.05e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 769928858  52 ILDISMPNESGLSLLE------DLPsgiaCIMLSVHDSATVVEKALSLGAKGFLSKRCSPDEL 108
Cdd:cd17584   49 ITDVHMPDMDGFEFLElirlemDLP----VIMMSADGSTSTVMKGLAHGACDYLLKPVSIEDL 107
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-112 5.59e-06

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 43.60  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEpDMDVVGqFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE---DLPSG--IACIML 78
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELE-GAEVTT-AHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARrlrELPWLanTPAIAL 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 769928858  79 SVHDSATVVEKALSLGAKGFLSKRCSPDELVQAV 112
Cdd:cd17580   79 TGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-58 1.01e-05

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.40  E-value: 1.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 769928858     2 IKVALVDDHIIVRSGFAQLLALEPDMdvVGQFSSAAEARAGLPGLDASVCILDISMP 58
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYE--VDEATDGEEALELLKEEKPDLILLDIMMP 55
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 97-193 1.13e-05

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 44.35  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  97 GFLSKRCS----PDELVQAVRTAAQggcylTPDIAINLVSPNQNKQalgkLTKREHQISELLATGLDVKAVAVKLGLSHK 172
Cdd:PRK11475  94 GVLSKASTleilQQELFLSLNGVRQ-----ATDRLNNQWYINQSRM----LSPTEREILRFMSRGYSMPQIAEQLERNIK 164

                         90       100
                 ....*....|....*....|.
gi 769928858 173 TIHVHRANAMDKLGVKNNVEL 193
Cdd:PRK11475 165 TIRAHKFNVMSKLGVSSDAGL 185
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 4-113 1.65e-05

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 42.37  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEP-DMDVVGQfssAAEARAGLPGLDASVCILDISMPNESGLSLLEDL--PSGIACIMLSV 80
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQEGyDVSEAGD---GEEMRQILARQDIDLVLLDINLPGKDGLSLTRELreQSEVGIILVTG 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:cd17619   80 RDDEVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 3-114 1.97e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 42.29  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSGFAQLLAlEPDMDVVgqfsSAAEARAGLPGLDA---SVCILDISMPNESGLSLLEDL---PS--GIA 74
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLR-GAGYEVV----EAADGRDALSKAQSkkfDLIITDQNMPNMDGIELIKELrklPAykFTP 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 769928858  75 CIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRT 114
Cdd:cd17562   77 ILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKK 116
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
138-194 2.85e-05

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 42.77  E-value: 2.85e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 769928858 138 QALGKLTK-REHQISELLATGLDVKAVAVKLGLSHKTIHVHRANAMDKLGVKNNVELA 194
Cdd:COG2909  117 RALGDREEaLAALRRRLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAV 174
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 39-114 4.42e-05

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 41.63  E-value: 4.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  39 ARAGLPGLdasvCILDISMPNESGLSLL------EDLPSgIACIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAV 112
Cdd:cd17557   48 ADAPRPDL----ILLDLNMPRMDGFEVLreikadPDLRR-IPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAI 122


                 ..
gi 769928858 113 RT 114
Cdd:cd17557  123 RS 124
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-158 7.38e-05

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 42.10  E-value: 7.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIVRSGFAQLLALEPDMDVVgqfssAAEARAGLPGLDASV--CILDISMPNESGLSLLEDLPSG--IACI 76
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLEMEGFNVIV-----AHDGEQALDLLDDSIdlLLLDVMMPKKNGIDTLKELRQThqTPVI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  77 MLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRT---------AAQGGCYLTPDIAINLVSPNQNKQA-------- 139
Cdd:PRK10955  76 MLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAilrrshwseQQQNNDNGSPTLEVDALSLNPGRQEasfdgqtl 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 769928858 140 ----------------LGKLTKREHQISELLATGL 158
Cdd:PRK10955 156 eltgteftllyllaqhLGQVVSREHLSQEVLGKRL 190
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-112 9.72e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 40.15  E-value: 9.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLL-ALEPDMDVVgqfSSAAEAraglpgLDA------SVCILDISMPNESGLSL------LEDLP 70
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLeKLGYEVDVA---ENGQEA------LELlkeepfDLVLMDLQMPVMDGLEAtrrireLEGGG 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769928858  71 SGIACIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAV 112
Cdd:cd17546   72 RRTPIIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
PRK10643 PRK10643
two-component system response regulator PmrA;
2-113 2.25e-04

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 40.79  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQllALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLE-------DLPSGIa 74
Cdd:PRK10643   1 MKILIVEDDTLLLQGLIL--ALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRrwrqkkyTLPVLI- 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 769928858  75 cimLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:PRK10643  78 ---LTARDTLEDRVAGLDVGADDYLVKPFALEELHARIR 113
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-113 2.28e-04

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 39.21  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEP-DMDVVgqfSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL--PSGIACIMLSV 80
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGfNVRAA---HDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELrkTSQVPVLMLTA 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:cd17623   78 RGDDIDRILGLELGADDYLPKPFNPRELVARIR 110
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-101 2.50e-04

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 38.97  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAqlLALEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL--PSGIACIMLSVH 81
Cdd:cd19936    1 IALVDDDRNILTSVS--MALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLrqKSTLPVIFLTSK 78

                         90       100
                 ....*....|....*....|
gi 769928858  82 DSATVVEKALSLGAKGFLSK 101
Cdd:cd19936   79 DDEIDEVFGLRMGADDYITK 98
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-117 3.23e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 38.92  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQLLALEpDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDL----PSgIACIM 77
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRRE-GYEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVreryPD-TVRIL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 769928858  78 LSVHDSATVVEKALSLGA-KGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd17569   78 LTGYADLDAAIEAINEGEiYRFLTKPWDDEELKETIRQALE 118
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 7-115 3.24e-04

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 38.63  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   7 VDDHIIVRsgfaQLLA--LEPDMDVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLP---SGIACIMLSVH 81
Cdd:cd17550    4 VDDEEDIR----ESLSgiLEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKekyPDLPVIMISGH 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 769928858  82 DS-ATVVeKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:cd17550   80 GTiETAV-KATKLGAYDFIEKPLSLDRLLLTIERA 113
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 54-101 4.34e-04

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 38.15  E-value: 4.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 769928858  54 DISMPNESGLSLLEDLPSGIAC-----IMLSVHDSATVVEKALSLGAKGFLSK 101
Cdd:cd17582   51 EVDLPVSSGFKLLSYIMRHKICknipvIMMSSQDSVGVVFKCLSKGAADYLVK 103
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 33-113 5.79e-04

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 38.23  E-value: 5.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  33 FSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSG---IACIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELV 109
Cdd:cd17624   28 VRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQgqsLPVLILTARDGVDDRVAGLDAGADDYLVKPFALEELL 107


                 ....
gi 769928858 110 QAVR 113
Cdd:cd17624  108 ARLR 111
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 33-115 7.01e-04

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 38.02  E-value: 7.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858  33 FSSAAEARAGLPGLDASVCILDISMPNESGLSLL----EDLPsGIACIMLSVH---DSATvveKALSLGAKGFLSKRCSP 105
Cdd:cd19919   30 FENAQEALAALASSQPDVLISDIRMPGMDGLALLaqikQRHP-DLPVIIMTAHsdlDSAV---SAYQGGAFEYLPKPFDI 105

                         90
                 ....*....|
gi 769928858 106 DELVQAVRTA 115
Cdd:cd19919  106 DEAVALVERA 115
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 50-117 8.64e-04

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 37.56  E-value: 8.64e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 769928858  50 VCILDISMPNESGLSLLE-----DLPSGIacIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTAAQ 117
Cdd:cd17572   45 VVLLDLKLPDMSGMEILKwiqerSLPTSV--IVITAHGSVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNALK 115
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 2-111 9.16e-04

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 37.52  E-value: 9.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   2 IKVALVDDHIIVRSGFAQllALEPDMDVVGQFssaaeARAGLPGLD------ASVCILDISMPNESGLSLLEDLP-SGIA 74
Cdd:cd17593    1 MKVLICDDSSMARKQLAR--ALPADWDVEITF-----AENGEEALEilregrIDVLFLDLTMPVMDGYEVLEALPvEQLE 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 769928858  75 C--IMLS--VHDSAtvVEKALSLGAKGFLSKRCSPDELVQA 111
Cdd:cd17593   74 TkvIVVSgdVQPEA--KERVLELGALAFLKKPFDPEKLAQL 112
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 50-101 1.09e-03

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 37.00  E-value: 1.09e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 769928858  50 VCILDISMPNESGLSLLEDL---PSGIACIMLSVHDSATVVEKALSLGAKGFLSK 101
Cdd:cd17574   44 LIILDVMLPGMDGFEVCRRLrekGSDIPIIMLTAKDEEEDKVLGLELGADDYITK 98
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 137-185 2.04e-03

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 37.33  E-value: 2.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 769928858  137 KQALGKLTKREHQISELLAT-GLDVKAVAVKLGLSHKTIHVHRANAMDKL 185
Cdd:TIGR02937 105 REALEKLPEREREVLVLRYLeGLSYKEIAEILGISVGTVKRRLKRARKKL 154
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-113 4.31e-03

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 35.82  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   4 VALVDDHIIVRSGFAQLLALEPDmdVVGQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSG---IACIMLSV 80
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGY--EVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAgndLPILVLTA 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:cd17627   79 RDSVSDRVAGLDAGADDYLVKPFALEELLARVR 111
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-113 4.37e-03

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 35.82  E-value: 4.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSGFAQLLAlEPDMDVVgQFSSAAEARAGLPGLDASVCILDISMPNESGLSLLEDLPSGIA--CIMLSV 80
Cdd:cd17622    2 RILLVEDDPKLARLIADFLE-SHGFNVV-VEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQgpILLLTA 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 769928858  81 HDSATVVEKALSLGAKGFLSKRCSPDELVQAVR 113
Cdd:cd17622   80 LDSDIDHILGLELGADDYVVKPVEPAVLLARLR 112
PRK10430 PRK10430
two-component system response regulator DcuR;
1-101 4.58e-03

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 37.01  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   1 MIKVALVDDHIIV----RSGFAQLlalePDMDVVGQFSSAAEARAGL--PGLDASVCILDISMPNESGLSLLEDLPSG-- 72
Cdd:PRK10430   1 MINVLIVDDDAMVaelnRRYVAQI----PGFQCCGTASTLEQAKEIIfnSDTPIDLILLDIYMQQENGLDLLPVLHEAgc 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 769928858  73 -IACIMLSVHDSATVVEKALSLGAKGFLSK 101
Cdd:PRK10430  77 kSDVIVISSAADAATIKDSLHYGVVDYLIK 106
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 3-115 4.99e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 35.60  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769928858   3 KVALVDDHIIVRSgFAQL-LALEPDMDVVGQfSSAAE----ARAGLPglDAsvCILDISMPNESGLSLLEDLPS-----G 72
Cdd:cd17552    3 RILVIDDEEDIRE-VVQAcLEKLAGWEVLTA-SSGQEglekAATEQP--DA--ILLDVMMPDMDGLATLKKLQAnpetqS 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769928858  73 IACIMLSVHDSATVVEKALSLGAKGFLSKRCSPDELVQAVRTA 115
Cdd:cd17552   77 IPVILLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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