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Conserved domains on  [gi|769942696|ref|WP_045076006|]
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response regulator transcription factor [Psychromicrobium lacuslunae]

Protein Classification

transcriptional regulator( domain architecture ID 1003377)

transcriptional regulator may belong to the NarL family and contain a C-terminal helix-turn-helix DNA-binding domain and an N-terminal REC domain, thereby functioning as a response regulator

Gene Ontology:  GO:0003677|GO:0006355|GO:0000160
PubMed:  16740923

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10651 super family cl32550
transcriptional regulator NarL; Provisional
 6-211 7.65e-43

transcriptional regulator NarL; Provisional


The actual alignment was detected with superfamily member PRK10651:

Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 143.63  E-value: 7.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESL-----DPDLILLDLNM-PGMNGLETLDKLREKSLSGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLI------ERISNPSIS-LTNREVQ 158
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAaslranRATTERDVNqLTPRERD 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 769942696 159 LLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRI 211
Cdd:PRK10651 163 ILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERI 215
 
Name Accession Description Interval E-value
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 6-211 7.65e-43

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 143.63  E-value: 7.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESL-----DPDLILLDLNM-PGMNGLETLDKLREKSLSGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLI------ERISNPSIS-LTNREVQ 158
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAaslranRATTERDVNqLTPRERD 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 769942696 159 LLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRI 211
Cdd:PRK10651 163 ILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERI 215
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 6-128 4.26e-38

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 128.01  E-value: 4.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGdGLDGVATTAKIRRLAQPPA 85
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLREL-----RPDVVLMDLSMP-GMDGIEALRRLRRRYPDLK 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:cd17535   75 VIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 4-213 5.82e-31

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 110.37  E-value: 5.82e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGdGLDGVATTAKIrrlaqp 83
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEEL-----RPDVVLLDIRMP-GMDGLEALRRL------ 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  84 pavlilttydtdadilaaveagasgyllkdappeqilsavlaaaagqsaltprvsallierisnpsisLTNREVQLLELL 163
Cdd:COG2197   70 --------------------------------------------------------------------LTPREREVLRLL 81

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 769942696 164 STGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRIIR 213
Cdd:COG2197   82 AEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-123 4.63e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 94.53  E-value: 4.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696    6 VLLVDDHPVVRAGLRAML--SGFdgvsVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGdGLDGVATTAKIRRLAQP 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLekEGY----VVAEADDGKEALELLKE-----ERPDLILLDINMP-GMDGLELLKRIRRRDPT 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 769942696   84 PAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:pfam00072  71 TPVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAI 110
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 151-206 2.74e-17

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 72.56  E-value: 2.74e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 769942696   151 SLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVA 206
Cdd:smart00421   3 SLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
 
Name Accession Description Interval E-value
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 6-211 7.65e-43

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 143.63  E-value: 7.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESL-----DPDLILLDLNM-PGMNGLETLDKLREKSLSGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLI------ERISNPSIS-LTNREVQ 158
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAaslranRATTERDVNqLTPRERD 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 769942696 159 LLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRI 211
Cdd:PRK10651 163 ILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERI 215
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
6-210 4.77e-40

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 136.14  E-value: 4.77e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAalgekVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:PRK10403   9 VLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLD-----PDVILLDLNM-KGMSGLDTLNALRRDGVTAQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLIERI-----SNPSISLTNREVQLL 160
Cdd:PRK10403  83 IIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREmfgaeEDPFSVLTERELDVL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 769942696 161 ELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRR 210
Cdd:PRK10403 163 HELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQR 212
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 6-128 4.26e-38

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 128.01  E-value: 4.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGdGLDGVATTAKIRRLAQPPA 85
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLREL-----RPDVVLMDLSMP-GMDGIEALRRLRRRYPDLK 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:cd17535   75 VIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 4-213 5.82e-31

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 110.37  E-value: 5.82e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGdGLDGVATTAKIrrlaqp 83
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEEL-----RPDVVLLDIRMP-GMDGLEALRRL------ 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  84 pavlilttydtdadilaaveagasgyllkdappeqilsavlaaaagqsaltprvsallierisnpsisLTNREVQLLELL 163
Cdd:COG2197   70 --------------------------------------------------------------------LTPREREVLRLL 81

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 769942696 164 STGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRIIR 213
Cdd:COG2197   82 AEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
PRK09483 PRK09483
response regulator; Provisional
 4-198 1.54e-28

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 106.73  E-value: 1.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQelhrlAALGEKVQLVLMDLQMgDGLDGVATTAKIRRLAQP 83
Cdd:PRK09483   2 INVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVK-----WCRTNAVDVVLMDMNM-PGIGGLEATRKILRYTPD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  84 PAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVS---AL--LIERISNPSISLTNREVQ 158
Cdd:PRK09483  76 VKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAqqmALsqIEPATENPFASLSERELQ 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 769942696 159 LLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDN 198
Cdd:PRK09483 156 IMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISG 195
PRK10360 PRK10360
transcriptional regulator UhpA;
4-198 1.14e-26

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 101.21  E-value: 1.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHrlaalGEKVQLVLMDLQMGD--GLDgvattaKIRRLA 81
Cdd:PRK10360   2 ITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLP-----GRGVQVCICDISMPDisGLE------LLSQLP 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  82 QPPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLIERISNPsisLTNREVQLLE 161
Cdd:PRK10360  71 KGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDP---LTKRERQVAE 147

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 769942696 162 LLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDN 198
Cdd:PRK10360 148 KLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSN 184
PRK15369 PRK15369
two component system response regulator;
1-200 1.36e-25

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 98.61  E-value: 1.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   1 MTDIGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAAlgekvQLVLMDLQMgDGLDGVATTAKIRRL 80
Cdd:PRK15369   1 MKNYKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEP-----DIVILDLGL-PGMNGLDVIPQLHQR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  81 AQPPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLIERIS-----NPSIsLTNR 155
Cdd:PRK15369  75 WPAMNILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALLnaddtNPPL-LTPR 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 769942696 156 EVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRT 200
Cdd:PRK15369 154 ERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVA 198
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-123 4.63e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 94.53  E-value: 4.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696    6 VLLVDDHPVVRAGLRAML--SGFdgvsVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGdGLDGVATTAKIRRLAQP 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLekEGY----VVAEADDGKEALELLKE-----ERPDLILLDINMP-GMDGLELLKRIRRRDPT 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 769942696   84 PAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:pfam00072  71 TPVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAI 110
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 6-197 1.42e-22

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 90.79  E-value: 1.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMGDgLDGVATTAKIRRLAQPPA 85
Cdd:COG0745    4 ILVVEDDPDIRELLADALER-EGYEVD-TAADGEEALELLEE-----ERPDLILLDLMLPG-MDGLEVCRRLRARPSDIP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLIE-----RISNPSISLTNREVQLL 160
Cdd:COG0745   76 IIMLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLRVGDLLDLaarevTRDGEPVELTPKEFRLL 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 769942696 161 ELLST----GLSNRAIAQRV----FISEATVKTHLVHIYDKLGVD 197
Cdd:COG0745  156 ELLMRnpgrVVSREQLLEEVwgydYGDDRTVDVHISRLRKKLEDD 200
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-112 5.32e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 86.37  E-value: 5.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGdGLDGVATTAKIRRLAQPPA 85
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEE-----HKPDLVITDINMP-GMDGLELLEAIRELDPDTK 75

                         90       100
                 ....*....|....*....|....*..
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:COG4753   76 IIILSGYSDFEYAQEAIKLGADDYLLK 102
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 6-132 1.42e-21

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 86.06  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:COG0784    8 ILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELLRA-----GPPDLILLDINM-PGMDGLELLRRIRALPRLPD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 769942696  86 --VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSA 132
Cdd:COG0784   80 ipIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 6-198 4.47e-21

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 86.31  E-value: 4.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVlAEAADGDAALQELHRLAAlgekvQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESA-GLRV-ETFASAEAFLAALDPDRP-----GCLLLDVRM-PGMSGLELQEELAARGSPLP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYdtdADILAAVEA---GASGYLLKDAPPEQILSAVLAA--AAGQSALTPRVSALLIERISnpsiSLTNREVQLL 160
Cdd:COG4566   74 VIFLTGH---GDVPMAVRAmkaGAVDFLEKPFDDQALLDAVRRAlaRDRARRAERARRAELRARLA----SLTPREREVL 146

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 769942696 161 ELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDN 198
Cdd:COG4566  147 DLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARS 184
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 140-212 1.72e-20

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 81.54  E-value: 1.72e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 769942696 140 LLIERISNPSISLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRII 212
Cdd:COG5905    1 MMPSSSTSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 6-128 1.78e-20

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 82.78  E-value: 1.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAAlgekvQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDP-----DLILLDLNM-KGMSGLDTLKALREEGVSAR 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:cd19931   75 IVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAAS 117
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-123 3.42e-20

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 84.87  E-value: 3.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGDgLDGVATTAKIRRLAQPPA 85
Cdd:COG3279    4 ILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEH-----KPDLVFLDIQMPG-LDGFELARQLRELDPPPP 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769942696  86 VLILTTYDTDAdiLAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:COG3279   78 IIFTTAYDEYA--LEAFEVNAVDYLLKPIDEERLAKAL 113
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-134 1.37e-19

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 81.17  E-value: 1.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   1 MTDIGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGDGlDGVATTAKIRRL 80
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAE-----HRPDLILLDIYLPDG-DGLELLRELRAR 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 769942696  81 AQPPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALT 134
Cdd:COG4565   75 GPDVDVIVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLR 128
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
1-212 7.14e-19

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 81.08  E-value: 7.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   1 MTDIGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAalgekVQLVLMDLQMgDGLDGVATTAKIRRL 80
Cdd:PRK09935   1 MKPASVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRP-----VDLIIMDIDL-PGTDGFTFLKRIKQI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  81 AQPPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSaLTPRVSALLIERISNPS-----ISLTNR 155
Cdd:PRK09935  75 QSTVKVLFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYT-FFPSETLNYIKSNKCSTnsstdTVLSNR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 769942696 156 EVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRII 212
Cdd:PRK09935 154 EVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-128 4.59e-18

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 81.55  E-value: 4.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgFDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMGDGlDGVATTAKIRRLAQPPA 85
Cdd:COG2204    5 ILVVDDDPDIRRLLKELLE-RAGYEVE-TAASGEEALALLRE-----EPPDLVLLDLRMPGM-DGLELLRELRALDPDLP 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:COG2204   77 VILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALE 119
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 6-123 1.21e-17

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 75.20  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRL---AQ 82
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKL-GYEVDV-AENGQEALELLKE-----EPFDLVLMDLQM-PVMDGLEATRRIRELeggGR 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 769942696  83 PPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17546   73 RTPIIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 7-112 1.26e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 74.57  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   7 LLVDDHPVVRAGLRAMLSGFdGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPAV 86
Cdd:cd00156    1 LIVDDDPAIRELLKSLLERE-GYEVD-TAADGEEALELLRE-----ERPDLVLLDLMM-PGMDGLELLRKLRELPPDIPV 72

                         90       100
                 ....*....|....*....|....*.
gi 769942696  87 LILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd00156   73 IVLTAKADEEDAVRALELGADDYLVK 98
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 6-128 1.31e-17

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 75.45  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFD-GVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGdGLDGVATTAKIRRLAQPP 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEElGFEVVGEAENGEEALELIEE-----HKPDIVITDIRMP-GMDGLELIEKIRELYPDI 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 769942696  85 AVLILTTYDtDADIL-AAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:cd17536   75 KIIILSGYD-DFEYAqKAIRLGVVDYLLKPVDEEELEEALEKAKE 118
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 151-206 2.74e-17

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 72.56  E-value: 2.74e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 769942696   151 SLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVA 206
Cdd:smart00421   3 SLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 6-123 7.66e-17

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 74.95  E-value: 7.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMGDgLDGVATTAKIR---RLAQ 82
Cdd:COG3706    4 ILVVDDDPTNRKLLRRLLEA-AGYEVV-EAADGEEALELLQE-----HRPDLILLDLEMPD-MDGLELCRRLRadpRTAD 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 769942696  83 PPaVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:COG3706   76 IP-IIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
7-211 1.12e-16

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 74.93  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   7 LLVDDHPVVRAGLRAMLSGfDGVSVLAEAADGDAALQELHRLAAlgekvQLVLMDLQMgDGLDGVATTAKIRRLAQPPAV 86
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIK-NDIEILAELTEGGSAVQRVETLKP-----DIVIIDVDI-PGVNGIQVLETLRKRQYSGII 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  87 LILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLIERISNPSI--SLTNREVQLLELLS 164
Cdd:PRK09958  77 IIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKldSLSKQEISVMRYIL 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 769942696 165 TGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRI 211
Cdd:PRK09958 157 DGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKI 203
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-123 1.95e-16

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 72.19  E-value: 1.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEEL-----KPDVVFLDIQM-PGLDGLELAKKLSKLAKPPL 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769942696  86 VLILTTYDTDAdiLAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17532   75 IVFVTAYDEYA--VEAFELNAVDYLLKPFSEERLAEAL 110
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 1-201 2.05e-16

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 74.48  E-value: 2.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   1 MTDIGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAAlgekvQLVLMDLQM-GDGL-DGVATTAKIR 78
Cdd:PRK10840   1 MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDA-----HVLITDLSMpGDKYgDGITLIKYIK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  79 RLAQPPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQiLSAVLAAAAGQSALTPRVSALLIERISNPSI---SLTNR 155
Cdd:PRK10840  76 RHFPSLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTD-LPKALAALQKGKKFTPESVSRLLEKISAGGYgdkRLSPK 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 769942696 156 EVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTA 201
Cdd:PRK10840 155 ESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIA 200
GerE pfam00196
Bacterial regulatory proteins, luxR family;
151-206 4.17e-16

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 69.54  E-value: 4.17e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 769942696  151 SLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVA 206
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 152-206 4.23e-16

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 69.49  E-value: 4.23e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 769942696 152 LTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVA 206
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 6-123 1.44e-15

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 69.99  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQelhrlAALGEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALR-----LVLKHSPDVAILDIEM-PGRTGLEVAAELREELPDTK 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd19930   75 VLIVTTFGRPGYFRRALAAGVDGYVLKDRPIEELADAI 112
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-132 2.57e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 71.73  E-value: 2.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQelhrlAALGEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:COG3437    9 VLIVDDDPENLELLRQLLRT-LGYDVV-TAESGEEALE-----LLLEAPPDLILLDVRM-PGMDGFELLRLLRADPSTRD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 769942696  86 --VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSA 132
Cdd:COG3437   81 ipVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRL 129
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-128 7.53e-15

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 69.99  E-value: 7.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   1 MTDIGVLLVDDHPVVRAGLRAMLSGfDGVSVLAEAADGDAALQelhrlAALGEKVQLVLMDLQMgDGLDGVATTAKIRRL 80
Cdd:COG3707    1 MRGLRVLVVDDEPLRRADLREGLRE-AGYEVVAEAADGEDAVE-----LVRELKPDLVIVDIDM-PDRDGLEAARQISEE 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 769942696  81 AQPPaVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:COG3707   74 RPAP-VILLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALA 120
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 4-130 1.54e-14

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 67.42  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMgDGLDGVATTAKIRRLaQP 83
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKEL-----KPDVITLDIEM-PVMDGLEALRRIMAE-RP 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 769942696  84 PAVLILTTYDT-DADI-LAAVEAGASGYLLKdapPEQILSAVLAAAAGQ 130
Cdd:cd17541   74 TPVVMVSSLTEeGAEItLEALELGAVDFIAK---PSGGISLDLEEIAEE 119
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 7-112 7.47e-14

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 64.74  E-value: 7.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   7 LLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMGdGLDGVATTAKIRRLAQPPAV 86
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEK-EGYEVD-TAADGEEALELARE-----EQPDLIILDVMLP-GMDGFEVCRRLREKGSDIPI 72

                         90       100
                 ....*....|....*....|....*.
gi 769942696  87 LILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17574   73 IMLTAKDEEEDKVLGLELGADDYITK 98
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 6-112 1.15e-13

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 64.74  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGDGLDGVATTAKIRRLAQPPa 85
Cdd:cd17534    3 ILIVEDEAIIALDLKEILESL-GYEVVGIADSGEEAIELAEE-----NKPDLILMDINLKGDMDGIEAAREIREKFDIP- 75

                         90       100
                 ....*....|....*....|....*...
gi 769942696  86 VLILTTYdTDADILA-AVEAGASGYLLK 112
Cdd:cd17534   76 VIFLTAY-SDEETLErAKETNPYGYLVK 102
PRK10100 PRK10100
transcriptional regulator CsgD;
77-206 2.52e-13

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 66.05  E-value: 2.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  77 IRRLAQPPAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPRVSALLIERISN------PSI 150
Cdd:PRK10100  75 LSRKNNNIKILLLNTPEDYPYREIENWPHINGVFYAMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNyrynstESA 154

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 769942696 151 SLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVA 206
Cdd:PRK10100 155 LLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWA 210
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 6-123 1.29e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 61.93  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQElhrlaALGEKVQLVLMDLQMGDgLDGVATTAKIRRLAQ--- 82
Cdd:cd17562    3 ILAVDDSASIRQMVSFTLRG-AGYEVV-EAADGRDALSK-----AQSKKFDLIITDQNMPN-MDGIELIKELRKLPAykf 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769942696  83 -PpaVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17562   75 tP--ILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVV 114
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
32-212 2.15e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 63.24  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  32 LAEAADGDAALQELHRLAALGEKVQLVLMDLQMGDGLDGVATTAKIRRLAQPPAVLILTTYDTDADILAAVEAGASGYLL 111
Cdd:COG2771    8 LLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696 112 KDAPPEQILSAVLAAAAGQSALTPRVSALLIERISNPSISLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIY 191
Cdd:COG2771   88 LALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIY 167

                        170       180
                 ....*....|....*....|.
gi 769942696 192 DKLGVDNRTAAIAVATQRRII 212
Cdd:COG2771  168 RKLGVSSRAELVALALRLGLI 188
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 6-123 3.23e-12

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 61.14  E-value: 3.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGDgLDGVATTAKIRRLAQPPA 85
Cdd:cd17542    3 VLIVDDAAFMRMMLKDILTK-AGYEVVGEAANGEEAVEKYKEL-----KPDLVTMDITMPE-MDGIEALKEIKKIDPNAK 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17542   76 VIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAV 113
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
161-213 8.28e-12

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 61.64  E-value: 8.28e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 769942696 161 ELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQRRIIR 213
Cdd:COG2909  132 RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-136 3.20e-11

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 59.54  E-value: 3.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLQMGDGlDGVATTAKIRRLAQPPA 85
Cdd:COG4567    7 LLLVDDDEAFARVLARALER-RGFEVTT-AASVEEALALLEQ-----APPDYAVLDLRLGDG-SGLDLIEALRERDPDAR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSALTPR 136
Cdd:COG4567   79 IVVLTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPPEN 129
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 6-128 3.63e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 58.19  E-value: 3.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGDgLDGVaTTAKIRRLAQPPA 85
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEE-AGYEVVGEASDGEEAVELAKKH-----KPDLVIMDVKMPR-LDGI-EAAKIITSENIAP 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:cd19932   75 IVLLTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIA 117
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
134-208 3.49e-10

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 58.80  E-value: 3.49e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 769942696 134 TPRVSALLieRISnpsiSLTNREVQLLELLSTGLSNRAIAQRVFISEATVKTHLVHIYDKLGVDNRTAAIAVATQ 208
Cdd:PRK04841 827 HPDVPELI--RTS----PLTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQD 895
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 6-125 4.63e-10

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 55.08  E-value: 4.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgFDGVSVLAeAADGDAALQElhrlaALGEKVQLVLMDLQMGDgLDGVATTAKIRRLAQPPA 85
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLR-FEGYEVET-AVDGAEALRV-----ISGNRPDAVVLDVMMPR-LDGLEVCRRLRAAGNDLP 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLA 125
Cdd:cd17627   73 ILVLTARDSVSDRVAGLDAGADDYLVKPFALEELLARVRA 112
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 6-127 1.07e-09

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 54.68  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgfDGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd17596    3 ILVVDDEVRSLEALRRTLE--EDFDVLT-AASAEEALAILEE-----EWVQVILCDQRM-PGTTGVEFLKEVRERWPEVV 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDADILAAV-EAGASGYLLKDAPPEQILSAVLAAA 127
Cdd:cd17596   74 RIIISGYTDSEDIIAGInEAGIYQYLTKPWHPDQLLLTVRNAA 116
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 6-112 1.14e-09

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 53.66  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTakiRRLAQPPA 85
Cdd:cd17538    2 ILVVDDEPANRELLEALLSA-EGYEVL-TADSGQEALALAEE-----ELPDLILLDVMM-PGMDGFEVC---RRLKEDPE 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 769942696  86 -----VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17538   71 trhipVIMITALDDREDRIRGLEAGADDFLSK 102
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 6-112 1.15e-09

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 53.71  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQElhrlaALGEKVQLVLMDLQMGDgLDGVATTAKIRRLAQPPa 85
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEA-HGYRVF-EAETGQEGLLE-----AATRKPDLIILDLGLPD-MDGLEVIRRLREWSAVP- 71

                         90       100
                 ....*....|....*....|....*..
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17620   72 VIVLSARDEESDKIAALDAGADDYLTK 98
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 6-123 1.34e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 54.34  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPvvrAGLRAMLSGFDGVSVLAE---AADGDAALQELHRLA--ALGEKVQLVLMDLQMgDGLDGVATTAKIR-- 78
Cdd:cd17557    2 ILLVEDNP---GDAELIQEAFKEAGVPNElhvVRDGEEALDFLRGEGeyADAPRPDLILLDLNM-PRMDGFEVLREIKad 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 769942696  79 -RLAQPPaVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17557   78 pDLRRIP-VVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAI 122
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 4-112 3.12e-09

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 53.02  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGDGlDGVATTAKIRRlAQP 83
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKE-----RQPDLILLDIYLPDG-NGLDLLRELRA-AGH 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 769942696  84 PAVLILTTYDTDADIL-AAVEAGASGYLLK 112
Cdd:cd19925   74 DVDVIVVTAANDVETVrEALRLGVVDYLIK 103
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 6-123 3.89e-09

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 52.77  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLsGFDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd17619    3 ILIVEDEPVTRATLKSYF-EQEGYDVS-EAGDGEEMRQILAR-----QDIDLVLLDINL-PGKDGLSLTRELREQSEVGI 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 769942696  86 VLIlTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17619   75 ILV-TGRDDEVDRIVGLEIGADDYVTKPFNPRELLVRA 111
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-119 5.72e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 52.34  E-value: 5.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIR---RLAQ 82
Cdd:cd19923    3 VLVVDDFSTMRRIIKNLLKEL-GFNNVEEAEDGVDALEKLKA-----GGFDFVITDWNM-PNMDGLELLKTIRadgALSH 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 769942696  83 PPaVLILTTYDTDADILAAVEAGASGYLLKDAPPEQI 119
Cdd:cd19923   76 LP-VLMVTAEAKKENVIAAAQAGVNNYIVKPFTAATL 111
PRK11697 PRK11697
two-component system response regulator BtsR;
4-141 7.76e-09

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 54.08  E-value: 7.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMG--DGLDGVATTAKIRRla 81
Cdd:PRK11697   2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRL-----KPDVVFLDIQMPriSGLELVGMLDPEHM-- 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 769942696  82 qpPAVLILTTYDTDAdiLAAVEAGASGYLLKDAPPE---QILSAVLAAAAGQSALTPRVSALL 141
Cdd:PRK11697  75 --PYIVFVTAFDEYA--IKAFEEHAFDYLLKPIDPArlaKTLARLRQERSPQDVLLPEAQPPL 133
PRK14084 PRK14084
DNA-binding response regulator;
6-128 1.69e-08

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 53.22  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELhrlaaLGEKVQLVLMDLQMGDGlDGVATTAKIRRLAQPPA 85
Cdd:PRK14084   3 ALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEAL-----LINQYDIIFLDINLMDE-SGIELAAKIQKMKEPPA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 769942696  86 VLILTTYDTDAdiLAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:PRK14084  77 IIFATAHDQFA--VKAFELNATDYILKPFEQKRIEQAVNKVRA 117
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 6-112 2.64e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 50.45  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLS--GFDgvsvLAEAADGDAALQELHRLAALG----EKVQLVLMDLQMgDGLDGVATTAKIR- 78
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKnlGFE----IAEAVDGEEALNKLENLAKEGndlsKELDLIITDIEM-PKMDGYELTFELRd 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 769942696  79 --RLAQPPaVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd19924   76 dpRLANIP-VILNSSLSGEFSRARGKKVGADAYLAK 110
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 6-112 5.17e-08

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 49.57  E-value: 5.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAEAADGDAALQELHRlaalgEKVQLVLMDLQMGDGLDG--VATTAKIRRLAQP 83
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSL-GVTRIDTASSGEEALRMCEN-----KTYDIVLCDYNLGKGKNGqqLLEELRHKKLISP 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 769942696  84 PAVLILTTYDTD-ADILAAVEAGASGYLLK 112
Cdd:cd17589   75 STVFIMVTGESSrAMVLSALELEPDDYLLK 104
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 6-112 5.40e-08

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 49.46  E-value: 5.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIR---RLAQ 82
Cdd:cd17548    2 ILIVEDNPLNMKLARDLLESA-GYEVL-EAADGEEALEIARK-----EKPDLILMDIQL-PGMDGLEATRLLKedpATRD 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 769942696  83 PPaVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17548   74 IP-VIALTAYAMKGDREKILEAGCDGYISK 102
PRK15115 PRK15115
response regulator GlrR; Provisional
 6-128 5.91e-08

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 52.15  E-value: 5.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRA--GLRAMLSGFDGVSvlaeAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQP 83
Cdd:PRK15115   8 LLLVDDDPGLLKllGMRLTSEGYSVVT----AESGQEALRVLNR-----EKVDLVISDLRM-DEMDGMQLFAEIQKVQPG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 769942696  84 PAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAA 128
Cdd:PRK15115  78 MPVIILTAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALE 122
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 6-121 9.19e-08

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 48.91  E-value: 9.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVrAGLRAMLSGFDGVSVLAEAaDGDAALQELHRlaalgEKVQLVLMDLqMGDGLDGVATTAKIRRLAQPPa 85
Cdd:cd17622    3 ILLVEDDPKL-ARLIADFLESHGFNVVVEH-RGDRALEVIAR-----EKPDAVLLDI-MLPGIDGLTLCRDLRPKYQGP- 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILS 121
Cdd:cd17622   74 ILLLTALDSDIDHILGLELGADDYVVKPVEPAVLLA 109
PRK11517 PRK11517
DNA-binding response regulator HprR;
6-165 1.33e-07

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 50.28  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgfDGVSVLAEAADGDAALQelhrlAALGEKVQLVLMDLqMGDGLDGVATTAKIRRLAQPPa 85
Cdd:PRK11517   3 ILLIEDNQRTQEWVTQGLS--EAGYVIDAVSDGRDGLY-----LALKDDYALIILDI-MLPGMDGWQILQTLRTAKQTP- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAVLAAAAGQSAL--TPRVSALLIERIS------NPSISLTNREV 157
Cdd:PRK11517  74 VICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALnsTLEISGLRMDSVSqsvsrdNISITLTRKEF 153


                 ....*...
gi 769942696 158 QLLELLST 165
Cdd:PRK11517 154 QLLWLLAS 161
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 6-124 1.40e-07

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 48.87  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHP-VVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAALGEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPP 84
Cdd:cd17595    3 ILTVDDDPqVLRAVARDLRRQYGKDYRVLRADSGAEALDALKELKLRGEAVALFLVDQRM-PEMDGVEFLEKAMELFPEA 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769942696  85 AVLILTTY-DTDADILAAVEAGASGYLLKD-APPEQILSAVL 124
Cdd:cd17595   82 KRVLLTAYaDTDAAIRAINDVQLDYYLLKPwDPPEEKLYPVL 123
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 6-128 2.39e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 47.78  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMGdGLDGVATTAKIRRLaQPPA 85
Cdd:cd17569    3 ILLVDDEPNILKALKRLLRR-EGYEVL-TATSGEEALEILKQ-----EPVDVVISDQRMP-GMDGAELLKRVRER-YPDT 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 769942696  86 V-LILTTYdtdADILAAVEAGASG----YLLKDAPPEQILSAVLAAAA 128
Cdd:cd17569   74 VrILLTGY---ADLDAAIEAINEGeiyrFLTKPWDDEELKETIRQALE 118
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 6-112 2.62e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 47.58  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd17555    3 ILVIDDDEVVRESIAAYLEDS-GFQVL-QAADGRQGLELFRS-----EQPDLVLCDLRM-PEMDGLEVLKQITKESPDTP 74

                         90       100
                 ....*....|....*....|....*..
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17555   75 VIVVSGAGVMSDAVEALRLGAWDYLTK 101
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 6-112 2.95e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 47.12  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLAeAADGDAALQelhrlAALGEKVQLVLMDLQMGdGLDGVATtakIRRLAQPPA 85
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRA-AGYRVLV-ATDGQQALQ-----RAQAEPPDLILLDVMMP-GMDGFEV---CRRLKADPA 69

                         90       100       110
                 ....*....|....*....|....*....|..
gi 769942696  86 -----VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd19920   70 trhipVIFLTALTDTEDKVKGFELGAVDYITK 101
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 6-64 4.37e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 45.25  E-value: 4.37e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 769942696     6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQM 64
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEK-EGYEVD-EATDGEEALELLKE-----EKPDLILLDIMM 54
PRK10610 PRK10610
chemotaxis protein CheY;
3-112 6.34e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 46.89  E-value: 6.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   3 DIGVLLVDDHPVVRAGLRAMLS--GFDGVSvlaEAADGDAALQELhRLAALGekvqLVLMDLQMG--DGLDGVATTAKIR 78
Cdd:PRK10610   5 ELKFLVVDDFSTMRRIVRNLLKelGFNNVE---EAEDGVDALNKL-QAGGFG----FVISDWNMPnmDGLELLKTIRADG 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 769942696  79 RLAQPPaVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:PRK10610  77 AMSALP-VLMVTAEAKKENIIAAAQAGASGYVVK 109
PRK15479 PRK15479
transcriptional regulator TctD;
6-163 1.03e-06

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 47.79  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLS--GFdgvsVLAEAADGDAALQELHrlaalGEKVQLVLMDLQMgDGLDGVATTAKIRRLAQP 83
Cdd:PRK15479   3 LLLAEDNRELAHWLEKALVqnGF----AVDCVFDGLAADHLLQ-----SEMYALAVLDINM-PGMDGLEVLQRLRKRGQT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  84 PAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQI---LSAVLAAAAGQSALTPRVSALLIE-----RISNPSISLTNR 155
Cdd:PRK15479  73 LPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELdarLRALLRRSAGQVQEVQQLGELIFHdegyfLLQGQPLALTPR 152


                 ....*...
gi 769942696 156 EVQLLELL 163
Cdd:PRK15479 153 EQALLTVL 160
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 6-125 1.15e-06

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 45.92  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAML--SGFDgvsvLAEAADGDAALQELHRlaalgEKVQLVLMDLqMGDGLDGVATTAKIRRLAQP 83
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLrgEGFD----PAFCGDGTQALAAFRE-----VRPDLVLLDL-MLPGIDGIEVCRQIRAESGV 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769942696  84 PAVLILTTYDTdADILAAVEAGASGYLLKDAPPEQILSAVLA 125
Cdd:cd17626   73 PIVMLTAKSDT-VDVVLGLESGADDYVAKPFKPKELVARIRA 113
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
6-106 1.96e-06

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 47.57  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLAAlgekvQLVLMDLQMGDgLDGVATTAKIRRLAqPPA 85
Cdd:PRK12555   3 IGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPP-----DVILMDLEMPR-MDGVEATRRIMAER-PCP 75

                         90       100
                 ....*....|....*....|....
gi 769942696  86 VLILTTyDTDAD---ILAAVEAGA 106
Cdd:PRK12555  76 ILIVTS-LTERNasrVFEAMGAGA 98
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 6-112 2.13e-06

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 44.68  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgFDGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIR---RLAQ 82
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLE-DQGFTVIA-ASNGLEALDLLNQ-----YIPDLIISDIIM-PGVDGYSLLGKLRknaDFDT 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 769942696  83 PPaVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd19927   73 IP-VIFLTAKGMTSDRIKGYNAGCDGYLSK 101
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
4-139 2.19e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 47.33  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFdGVSVlAEAADGDAALQELHrlaalGEKVQLVLMDLQMGDgLDGVATTAKIRRLAQP 83
Cdd:PRK10365   6 IDILVVDDDISHCTILQALLRGW-GYNV-ALANSGRQALEQVR-----EQVFDLVLCDVRMAE-MDGIATLKEIKALNPA 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 769942696  84 PAVLILTTYDTDADILAAVEAGASGYLLKDAP---PEQILSAVLAAAAGQSALTPRVSA 139
Cdd:PRK10365  78 IPVLIMTAYSSVETAVEALKTGALDYLIKPLDfdnLQATLEKALAHTHSIDAETPAVTA 136
PRK10336 PRK10336
two-component system response regulator QseB;
6-197 2.37e-06

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 46.81  E-value: 2.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLS--GFDgVSVLAEAADGDAALQELHRLAalgekvqlVLMDLQMgDGLDGVATTAKIRRLAQP 83
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSkmGFS-VDWFTQGRQGKEALYSAPYDA--------VILDLTL-PGMDGRDILREWREKGQR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  84 PAVLILTTYDTDADILAAVEAGASGYLLKDAPPEQI---LSAVLAAAAGQSALTPRVSAL------LIERISNPSISLTN 154
Cdd:PRK10336  73 EPVLILTARDALAERVEGLRLGADDYLCKPFALIEVaarLEALMRRTNGQASNELRHGNVmldpgkRIATLAGEPLTLKP 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 769942696 155 REVQLLELLSTG----LSNRAIAQRVF-----ISEATVKTHLVHIYDKLGVD 197
Cdd:PRK10336 153 KEFALLELLMRNagrvLPRKLIEEKLYtwdeeVTSNAVEVHVHHLRRKLGSD 204
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 6-112 2.41e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 44.78  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSV--LAEAADGDAALQElhrlaalgEKVQLVLMDLQMGDGlDGVATTAKIRRLAQP 83
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRK-AGYAVdwVRTGAEAEAALAS--------GPYDLVILDLGLPDG-DGLDLLRRWRRQGQS 70

                         90       100
                 ....*....|....*....|....*....
gi 769942696  84 PAVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17624   71 LPVLILTARDGVDDRVAGLDAGADDYLVK 99
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 6-123 3.89e-06

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 44.37  E-value: 3.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgFDGVSVLAeAADGDAALQelhrlAALGEKVQLVLMDLQMgDGLDGVATTAKIRR---LAQ 82
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLE-LEGAEVTT-AHSGEEALE-----AAQRFRPDVILSDIGM-PGMDGYELARRLRElpwLAN 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 769942696  83 PPAVlILTTYDTDADILAAVEAGASGYLLKDAPPEQILSAV 123
Cdd:cd17580   73 TPAI-ALTGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 6-93 4.10e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 43.87  E-value: 4.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLaEAADGDAALQELHRlaalGEKVQLVLMDLQMGDGLDGVATTAKIRRLAQPPA 85
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDL-GYTVL-EAASGDEALDLLES----GPDIDLLVTDVIMPGGMNGSQLAEEARRRRPDLK 74


                 ....*...
gi 769942696  86 VLILTTYD 93
Cdd:cd18161   75 VLLTSGYA 82
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 6-122 4.52e-06

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 43.97  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGL-RAMLS-GFDgVSVlaeAADGDAALQelhrlAALGEKVQLVLMDLQMGD--GLDGVAttaKIRRLA 81
Cdd:cd17563    3 LLLVDDDEVFAERLaRALERrGFE-VET---AHSVEEALA-----LAREEKPDYAVLDLRLGGdsGLDLIP---PLRALQ 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 769942696  82 QPPAVLILTTYdtdADILAAVEA---GASGYLLKDAPPEQILSA 122
Cdd:cd17563   71 PDARIVVLTGY---ASIATAVEAiklGADDYLAKPADADEILAA 111
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 6-159 5.49e-06

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 45.78  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDgVSVLAEAAdGDAALQELHRlaalgEKVQLVLMDLqMGDGLDGVATTAKIRRLAQPPA 85
Cdd:PRK10701   4 IVFVEDDAEVGSLIAAYLAKHD-IDVTVEPR-GDRAEATILR-----EQPDLVLLDI-MLPGKDGMTICRDLRPKWQGPI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696  86 VLiLTTYDTDADILAAVEAGASGYLLKDAPPeqilsAVLAA-------AAGQSALTPRVSALLIE-----RISNPSISLT 153
Cdd:PRK10701  76 VL-LTSLDSDMNHILALEMGACDYILKTTPP-----AVLLArlrlhlrQNEQATQTKGLQETSLTpykalHFGTLTIDPV 149


                 ....*.
gi 769942696 154 NREVQL 159
Cdd:PRK10701 150 NRQVTL 155
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 6-119 5.50e-06

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 43.77  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGF-DGVSVLAEAADGDAALQElhrlaaLGEKVQLVLMDLQMGDgLDGVATTAKIRRLAQPP 84
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCgYQVTTCTDAEEALSMLRE------NKDEFDLVITDVHMPD-MDGFEFLELIRLEMDLP 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 769942696  85 AVLILTTYDTDAdILAAVEAGASGYLLKDAPPEQI 119
Cdd:cd17584   74 VIMMSADGSTST-VMKGLAHGACDYLLKPVSIEDL 107
PRK10643 PRK10643
two-component system response regulator PmrA;
6-112 6.03e-06

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 45.41  E-value: 6.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSG----FDGVSVLAEAadgDAALQELHrlaalgekVQLVLMDLQMGDGlDGVATTAKIRRLA 81
Cdd:PRK10643   3 ILIVEDDTLLLQGLILALQTegyaCDCASTAREA---EALLESGH--------YSLVVLDLGLPDE-DGLHLLRRWRQKK 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 769942696  82 QPPAVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:PRK10643  71 YTLPVLILTARDTLEDRVAGLDVGADDYLVK 101
ompR PRK09468
osmolarity response regulator; Provisional
 6-124 1.31e-05

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 44.58  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLqMGDGLDGVATTAKIRRLAQPPA 85
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTE-QGFQVRS-AANAEQMDRLLTR-----ESFHLMVLDL-MLPGEDGLSICRRLRSQNNPTP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQILS---AVL 124
Cdd:PRK09468  80 IIMLTAKGEEVDRIVGLEIGADDYLPKPFNPRELLArirAVL 121
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 6-123 3.54e-05

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 42.09  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgFDGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd17549    1 VLLVDDDADVREALQQTLE-LAGFRVRA-FADAEEALAALSP-----DFPGVVISDIRM-PGMDGLELLAQIRELDPDLP 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 769942696  86 VLILTTYdtdADILAAVEA---GASGYLLKDAPPEQILSAV 123
Cdd:cd17549   73 VILITGH---GDVPMAVEAmraGAYDFLEKPFDPERLLDVV 110
PRK15347 PRK15347
two component system sensor kinase;
6-130 1.26e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 42.32  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAeAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTakiRRLAQPPA 85
Cdd:PRK15347 693 ILLVDDVETNRDIIGMMLVEL-GQQVTT-AASGTEALELGRQ-----HRFDLVLMDIRM-PGLDGLETT---QLWRDDPN 761

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 769942696  86 VLilttyDTDADILA------------AVEAGASGYLLKDAPPEQILSAVLAAAAGQ 130
Cdd:PRK15347 762 NL-----DPDCMIVAltanaapeeihrCKKAGMNHYLTKPVTLAQLARALELAAEYQ 813
PRK10766 PRK10766
two-component system response regulator TorR;
6-112 3.54e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 40.41  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLaEAADGDAALQELHRlaalgEKVQLVLMDLQMgDGLDGVATTAKIRrlAQPPA 85
Cdd:PRK10766   5 ILVVEDEPVTRARLQGYFEQ-EGYTVS-EAASGAGMREIMQN-----QHVDLILLDINL-PGEDGLMLTRELR--SRSTV 74

                         90       100
                 ....*....|....*....|....*...
gi 769942696  86 VLILTTYDTDA-DILAAVEAGASGYLLK 112
Cdd:PRK10766  75 GIILVTGRTDSiDRIVGLEMGADDYVTK 102
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 6-112 4.70e-04

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 38.19  E-value: 4.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGfDGVSVLAeAADGDAALQelhrlAALGEKVQLVLMDLqMGDGLDGVATTAKIRRLAQPPA 85
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTE-EGYAVDV-AYDGEDGLH-----LALTNEYDLIILDV-MLPGLDGLEVLRRLRAAGKQTP 72

                         90       100
                 ....*....|....*....|....*..
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd19935   73 VLMLTARDSVEDRVKGLDLGADDYLVK 99
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 6-120 5.16e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 38.42  E-value: 5.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAeAADGDAALqelhrLAALGEKVQLVLMDLQMgDGLDGVATTAKIRRLAQPPA 85
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDA-GYVVDV-AEDGEEAL-----FQGEEEPYDLVVLDLGL-PGMDGLSVLRRWRSEGRATP 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLKDAPPEQIL 120
Cdd:cd19934   73 VLILTARDSWQDKVEGLDAGADDYLTKPFHIEELL 107
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 8-78 5.36e-04

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 38.02  E-value: 5.36e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 769942696   8 LVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMgDGLDGVATTAKIR 78
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFL-----QPDIVLIDLLM-PGMDGIQLVRKLK 67
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 6-124 2.13e-03

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 36.84  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLS--GFDGVsvlaEAADGDAALQELHRlaalgEKVQLVLMDLqMGDGLDGVATTAKIRR---L 80
Cdd:cd17618    3 ILIVEDEPAIREMIAFNLEraGFDVV----EAEDAESAVNLIVE-----PRPDLILLDW-MLPGGSGIQFIRRLKRdemT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 769942696  81 AQPPaVLILTTYDTDADILAAVEAGASGYLLKDAPPEQILS---AVL 124
Cdd:cd17618   73 RDIP-IIMLTARGEEEDKVRGLEAGADDYITKPFSPRELVArikAVL 118
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 6-112 2.34e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 36.56  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSgFDGVSVLAeAADGDAALQELHRLAAlgekvQLVLMDLQMGDgLDGVATTAKIRRLAQPPA 85
Cdd:cd17615    2 VLVVDDEPNITELLSMALR-YEGWDVET-AADGAEALAAAREFRP-----DAVVLDIMLPD-MDGLEVLRRLRADGPDVP 73

                         90       100
                 ....*....|....*....|....*..
gi 769942696  86 VLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17615   74 VLFLTAKDSVEDRIAGLTAGGDDYVTK 100
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 4-112 3.25e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 36.05  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   4 IGVLLVDDHPVVRAGLRAMLSGFDGVSVLAEAADGDAALQELHRLaalgeKVQLVLMDLQMGDgLDGVATTAKIR--RLA 81
Cdd:cd17561    2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEK-----EPDVLLLDIIMPH-LDGIGVLEKLRrmRLE 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 769942696  82 QPPAVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd17561   76 KRPKIIMLTAFGQEDITQRAVELGASYYILK 106
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 6-122 4.14e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 35.98  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFDGVSVLaEAADGDAALQelhRLAAlgEKVQLVLMDLQMGDgLDGVATTAKIRRLAQPPA 85
Cdd:cd17593    3 VLICDDSSMARKQLARALPADWDVEIT-FAENGEEALE---ILRE--GRIDVLFLDLTMPV-MDGYEVLEALPVEQLETK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 769942696  86 VLILTtydtdADI-----LAAVEAGASGYLLKDAPPEQILSA 122
Cdd:cd17593   76 VIVVS-----GDVqpeakERVLELGALAFLKKPFDPEKLAQL 112
PRK13557 PRK13557
histidine kinase; Provisional
 6-98 4.62e-03

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 37.34  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAeAADGDAALQELHRlaalGEKVQLVLMDLQMGDGLDGVATTAKIRRLaQPPA 85
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDF-GYRTLV-ASNGREALEILDS----HPEVDLLFTDLIMPGGMNGVMLAREARRR-QPKI 490

                         90
                 ....*....|...
gi 769942696  86 VLILTTYDTDADI 98
Cdd:PRK13557 491 KVLLTTGYAEASI 503
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 6-112 8.87e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 35.07  E-value: 8.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 769942696   6 VLLVDDHPVVRAGLRAMLSGFdGVSVLAeAADGDAALQelhRLAALGEKVQLVLMDLQMgDGLDGVATTAKIRRL---AQ 82
Cdd:cd19933    3 VLLVDDNAVNRMVTKGLLEKL-GCEVTT-VSSGEECLN---LLASAEHSFQLVLLDLCM-PEMDGFEVALRIRKLfgrRE 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 769942696  83 PPAVLILTTYDTDADILAAVEAGASGYLLK 112
Cdd:cd19933   77 RPLIVALTANTDDSTREKCLSLGMNGVITK 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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