|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
6-215 |
2.16e-127 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 358.28 E-value: 2.16e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 6 KYYNDSKTSFTKHRVERFSSRQAARRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIPVQGVYAAGRLDRDSEGLL 85
Cdd:PRK11394 7 SENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 86 VLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRERKSIPTS 165
Cdd:PRK11394 87 VLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTS 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 779874222 166 WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGSYTLETLANGEWRDVT 215
Cdd:PRK11394 167 WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREAT 216
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
40-206 |
5.29e-102 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 291.98 E-value: 5.29e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 40 VILFNKPYDVLPQFTDEA-GRSTLKDYIPVQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDD 118
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYIDDPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVPTE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 119 ATLAALRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 198
Cdd:cd02566 81 DALEQLRNGVELGDGLTLPAKVEKVDEPPWLWEREPPIRFRKNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRVSI 160
|
....*...
gi 779874222 199 GSYTLETL 206
Cdd:cd02566 161 GDIGLDNL 168
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
74-216 |
9.96e-63 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 191.00 E-value: 9.96e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 74 AGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEPEWlwprn 153
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEPGF----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 779874222 154 ppirerksiPTsWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGSYTLETLANGEWRDVTP 216
Cdd:TIGR00093 76 ---------PT-WLRVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRPLTL 128
|
|
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
30-215 |
3.67e-60 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 187.93 E-value: 3.67e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 30 RRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIP---VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGK 106
Cdd:COG1187 54 KPLKLPEEPVYLLLNKPAGVVSTTKDPEGRPTVFDLLPearKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 107 IYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNepewlwprnppirerkSIPTSWLKITLYEGRNRQVRRMTAHV 186
Cdd:COG1187 134 EYLVRVDGPVTEEDLERLREGVELEDGPTKPAKVEILS----------------GEANTWLRITLTEGRNRQVRRMFEAV 197
|
170 180
....*....|....*....|....*....
gi 779874222 187 GFPTLRLIRYAMGSYTLETLANGEWRDVT 215
Cdd:COG1187 198 GLPVVRLKRVRIGPLTLGDLPPGEWRELT 226
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
40-185 |
1.13e-17 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 76.29 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 40 VILFNKPYDVLPQFTD-EAGRSTLKDYIPVQG-----VYAAGRLDRDSEGLLVLTNDGALQAKLTQ--PGKRTGKIYFVQ 111
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDsLTKLLSLLALLLRRElgvkrLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 779874222 112 VEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEPEWLWprnPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 185
Cdd:pfam00849 81 VDKPEEEEGTIKSPIKKEKNKSPFRKEEELGGKKAVTHL---KVLKSGSKGDYSLLELELVTGRKHQIRAHLAA 151
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
6-215 |
2.16e-127 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 358.28 E-value: 2.16e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 6 KYYNDSKTSFTKHRVERFSSRQAARRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIPVQGVYAAGRLDRDSEGLL 85
Cdd:PRK11394 7 SENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 86 VLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRERKSIPTS 165
Cdd:PRK11394 87 VLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTS 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 779874222 166 WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGSYTLETLANGEWRDVT 215
Cdd:PRK11394 167 WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREAT 216
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
40-206 |
5.29e-102 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 291.98 E-value: 5.29e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 40 VILFNKPYDVLPQFTDEA-GRSTLKDYIPVQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDD 118
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYIDDPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVPTE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 119 ATLAALRSGVTLNDGPTLPAGIERVNEPEWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 198
Cdd:cd02566 81 DALEQLRNGVELGDGLTLPAKVEKVDEPPWLWEREPPIRFRKNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRVSI 160
|
....*...
gi 779874222 199 GSYTLETL 206
Cdd:cd02566 161 GDIGLDNL 168
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
74-216 |
9.96e-63 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 191.00 E-value: 9.96e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 74 AGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEPEWlwprn 153
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEPGF----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 779874222 154 ppirerksiPTsWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGSYTLETLANGEWRDVTP 216
Cdd:TIGR00093 76 ---------PT-WLRVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRPLTL 128
|
|
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
30-215 |
3.67e-60 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 187.93 E-value: 3.67e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 30 RRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIP---VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGK 106
Cdd:COG1187 54 KPLKLPEEPVYLLLNKPAGVVSTTKDPEGRPTVFDLLPearKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 107 IYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNepewlwprnppirerkSIPTSWLKITLYEGRNRQVRRMTAHV 186
Cdd:COG1187 134 EYLVRVDGPVTEEDLERLREGVELEDGPTKPAKVEILS----------------GEANTWLRITLTEGRNRQVRRMFEAV 197
|
170 180
....*....|....*....|....*....
gi 779874222 187 GFPTLRLIRYAMGSYTLETLANGEWRDVT 215
Cdd:COG1187 198 GLPVVRLKRVRIGPLTLGDLPPGEWRELT 226
|
|
| PseudoU_synth_RsuA_like |
cd02870 |
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the ... |
40-197 |
1.82e-51 |
|
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this family are bacterial proteins.
Pssm-ID: 211347 [Multi-domain] Cd Length: 146 Bit Score: 163.05 E-value: 1.82e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 40 VILFNKPYDVLPQFTDEAGRSTLKDYIP--VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPD 117
Cdd:cd02870 1 YLLLNKPRGVVSTVRDPEGRPTVLDLLKdvGERLFPVGRLDYDTEGLLLLTNDGELANRLTHPRYGVEKTYLVKVRGVPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 118 DATLAALRSGVTLNDGPTLPAGIERVNEPEwlwprnppirerksiPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYA 197
Cdd:cd02870 81 EEELRRLRAGVELDDGKTAPAKVKVLSRDP---------------KNTLLEVTLHEGRNRQVRRMFEAVGHPVLRLKRVR 145
|
|
| PseudoU_synth_RsuA |
cd02553 |
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and ... |
39-216 |
2.46e-44 |
|
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.
Pssm-ID: 211327 [Multi-domain] Cd Length: 167 Bit Score: 145.74 E-value: 2.46e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 39 RVILFNKPYDVLPQFTDEAGRSTLkDYIPVQ----GVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEG 114
Cdd:cd02553 1 VYLMLNKPAGVVCATKDPHHPTVI-DLLPEPdrrrDLFPVGRLDKDTTGLLLLTNDGQLAHRLTSPKKHVPKTYEVTLAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 115 EPDDATLAALRSGVTLNDG-PTLPAGIERVNEpewlwprnppirerksiptSWLKITLYEGRNRQVRRMTAHVGFPTLRL 193
Cdd:cd02553 80 PLTEDDIEAFAEGVLLHDGyPTKPAKLEILSP-------------------TTVRLTITEGKYHQVKRMFAAVGNKVVAL 140
|
170 180
....*....|....*....|....
gi 779874222 194 IRYAMGSYTL-ETLANGEWRDVTP 216
Cdd:cd02553 141 HRIRIGGLELdDDLAPGEWRPLTE 164
|
|
| PseudoU_synth_RluB |
cd02556 |
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and ... |
39-216 |
4.64e-35 |
|
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluB makes psi2605 in 23S RNA. psi2605 has been detected in eubacteria but, not in eukarya and archea despite the presence of a precursor U at that site.
Pssm-ID: 211330 [Multi-domain] Cd Length: 167 Bit Score: 122.03 E-value: 4.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 39 RVILFNKPYDVLPQFTDEAGRSTLKDYIPVQG---VYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGE 115
Cdd:cd02556 1 RVLIYHKPEGLICTRKDPKGRPTVFDLLPKLGiprWISVGRLDLNTEGLLLFTNDGELANRLMHPSNEIEREYAVRVFGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 116 PDDATLAALRSGVTLNDGPTLPagIERVNEpewlwprnppiRERKSipTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 195
Cdd:cd02556 81 VTDEQLKSLKKGVELEDGFAGF--KSIQLE-----------GGEGK--NSWYRVTLREGRNREVRRLWEAFGLQVSRLIR 145
|
170 180
....*....|....*....|..
gi 779874222 196 YAMGSYTL-ETLANGEWRDVTP 216
Cdd:cd02556 146 IRYGPIFLpGNLKRGQWEELPP 167
|
|
| PseudoU_synth_Rsu_Rlu_like |
cd02550 |
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and ... |
40-195 |
8.01e-35 |
|
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.
Pssm-ID: 211325 [Multi-domain] Cd Length: 154 Bit Score: 120.94 E-value: 8.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 40 VILFNKPYDVLPQFTDEAGRSTLKDYIPVQG---VYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEP 116
Cdd:cd02550 1 ILVLNKPSGLVCHPTDRDRDPTVVVRLDKLHgprVHAAGRLDKDTSGLLLLTNDGRLQRRLTEPRREIEKEYLVTVRGEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 117 DDATLAAL-------RSGVTLNDGPTLPAGIERVNEPEwlwprnppirerksiPTSWLKITLYEGRNRQVRRMTAHVGFP 189
Cdd:cd02550 81 DEEGIEDLatvrrgrLSGLVDEGVPLAVTKVRVIGEHG---------------GTGRLRLTLKTGRTHQIRRHCAAVGFP 145
|
....*.
gi 779874222 190 TLRLIR 195
Cdd:cd02550 146 VLRLHR 151
|
|
| PseudoU_synth_RluF |
cd02554 |
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial ... |
41-216 |
3.83e-30 |
|
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluF makes psi2604 in 23S RNA. psi2604 has only been detected in E. coli. It is absent from other eubacteria despite a precursor U at that site and from eukarya and archea which lack a precursor U at that site.
Pssm-ID: 211328 [Multi-domain] Cd Length: 164 Bit Score: 109.32 E-value: 3.83e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 41 ILFNKPYDVLPQfTDEAGRSTLKDYI-PVQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDA 119
Cdd:cd02554 3 IAYNKPVGIDCT-LERADEDNIIDFVnPPPRIFPIGRLDKDSEGLILLTNDGDLVNKILHADNNHEKEYLVTVNKPITDE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 120 TLAALRSGVTLNDGPTLPAGIERVNEpewlwprnppirerksiptSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 199
Cdd:cd02554 82 FIEGMSNGVVILGTVTKPCKVERLAK-------------------DKFRIVLTQGLNRQIRRMCEALGYRVTDLKRVRIM 142
|
170
....*....|....*..
gi 779874222 200 SYTLETLANGEWRDVTP 216
Cdd:cd02554 143 NIELGDLAPGEWRPLTD 159
|
|
| PRK10700 |
PRK10700 |
23S rRNA pseudouridine(2605) synthase RluB; |
10-211 |
4.81e-22 |
|
23S rRNA pseudouridine(2605) synthase RluB;
Pssm-ID: 182659 [Multi-domain] Cd Length: 289 Bit Score: 90.98 E-value: 4.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 10 DSKTSFTKHRVE-------RFSSRQAARRPQETQPKRVILFNKPYDVLPQFTDEAGRSTLKDYIP-VQGV--YAAGRLDR 79
Cdd:PRK10700 32 DGKIATLGDRVEvtpglkiRIDGHLISVKESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPkLRGArwIAVGRLDV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 80 DSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGP----TLP-AGIERVNEpewlwprnp 154
Cdd:PRK10700 112 NTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRQLSRGVQLEDGPaafkTIKfSGGEGINQ--------- 182
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 779874222 155 pirerksiptsWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGSYTL-ETLANGEW 211
Cdd:PRK10700 183 -----------WYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIPLpKGLPRGGW 229
|
|
| PRK10475 |
PRK10475 |
23S rRNA pseudouridine(2604) synthase RluF; |
32-216 |
1.75e-20 |
|
23S rRNA pseudouridine(2604) synthase RluF;
Pssm-ID: 236698 [Multi-domain] Cd Length: 290 Bit Score: 87.09 E-value: 1.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 32 PQETQPKRVILFNKPYDVLPQfTDEAGRSTLKDYIP-VQGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFV 110
Cdd:PRK10475 61 PREAEDLVLIALNKPVGIVST-TEDGERDNIVDFVNhSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 111 QVEGEPDDATLAALRSGVtlndgPTLPAGIERVnepewlwprnppiRERKSIPTSWlKITLYEGRNRQVRRMTAHVGFPT 190
Cdd:PRK10475 140 TVDKPITDEFIRGMGAGV-----PILGTVTKKC-------------KVKKEAPFVF-RITLVQGLNRQIRRMCEHFGYEV 200
|
170 180
....*....|....*....|....*.
gi 779874222 191 LRLIRYAMGSYTLETLANGEWRDVTP 216
Cdd:PRK10475 201 TKLERTRIMNVSLSGIPLGEWRDLTD 226
|
|
| PSSA_1 |
cd02555 |
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial ... |
73-216 |
6.45e-19 |
|
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. The TruA family is comprised of proteins related to Escherichia coli RsuA.
Pssm-ID: 211329 [Multi-domain] Cd Length: 177 Bit Score: 80.53 E-value: 6.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 73 AAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEpewlwpr 152
Cdd:cd02555 49 PIGPLDKDASGLLVFSQDGRVLRKLIGDASRLEQEYLVEVRGELTAGGLERLNHGLTYDGRELPPAKVSWQNE------- 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 779874222 153 nppirerksiptSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGSYTLETLANGEWRDVTP 216
Cdd:cd02555 122 ------------QRLRFALKEPQPGQIRRMCESVGLEVVALRRIRIGRVSLGKLPLGQWRYLTT 173
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
40-185 |
1.13e-17 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 76.29 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 40 VILFNKPYDVLPQFTD-EAGRSTLKDYIPVQG-----VYAAGRLDRDSEGLLVLTNDGALQAKLTQ--PGKRTGKIYFVQ 111
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDsLTKLLSLLALLLRRElgvkrLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 779874222 112 VEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEPEWLWprnPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 185
Cdd:pfam00849 81 VDKPEEEEGTIKSPIKKEKNKSPFRKEEELGGKKAVTHL---KVLKSGSKGDYSLLELELVTGRKHQIRAHLAA 151
|
|
| PRK10839 |
PRK10839 |
16S rRNA pseudouridine(516) synthase RsuA; |
33-216 |
4.66e-16 |
|
16S rRNA pseudouridine(516) synthase RsuA;
Pssm-ID: 236774 [Multi-domain] Cd Length: 232 Bit Score: 73.99 E-value: 4.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 33 QETQPkRVILFNKPYDVLPQfTDEAGRSTLKDYI--PV-QGVYAAGRLDRDSEGLLVLTNDGALQAKLTQPGKRTGKIYF 109
Cdd:PRK10839 56 QQHGP-RYFMLNKPQGYVCS-TDDPDHPTVLYFLdePVaYKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 110 VQVEGEPDDATLAALRSGVTLNDGPTL--PAGIERVNEPEwlwprnppirerksiptswLKITLYEGRNRQVRRMTAHVG 187
Cdd:PRK10839 134 VTLESPVADDTAEQFAKGVQLHNEKDLtkPAVLEVITPTQ-------------------VRLTISEGRYHQVKRMFAAVG 194
|
170 180 190
....*....|....*....|....*....|
gi 779874222 188 FPTLRLIRYAMGSYTL-ETLANGEWRDVTP 216
Cdd:PRK10839 195 NHVVELHRERIGAITLdADLAPGEYRPLTE 224
|
|
| PseudoU_synth_TruC |
cd02563 |
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific ... |
69-191 |
1.21e-03 |
|
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not universally conserved.
Pssm-ID: 211333 [Multi-domain] Cd Length: 223 Bit Score: 38.86 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779874222 69 QGVYAAGRLDRDSEGLLVLTNDGALQAKLTQ--PGKRTGKIYFVQVEGEPDDATLAALRSGVTLNDGPTLPAGIERVNEP 146
Cdd:cd02563 44 QHVYPVHRLDRPTSGVLLFALSSEVARKLGEqfTEHRVHKTYLAVVRGYVPESGTIDYPLSEELDKLADKFASDDKAPQA 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 779874222 147 EWLWPR-----NPPIRERKsIPT---SWLKITLYEGRNRQVRRMTAHVGFPTL 191
Cdd:cd02563 124 ATTHYRllaveELPVVVGK-YPTsrySLVELTPHTGRKHQLRRHLAHIRHPII 175
|
|
| |
