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Conserved domains on  [gi|779957075|ref|WP_045404534|]
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MULTISPECIES: amino acid-binding protein [Enterobacter]

Protein Classification

ACTx2 family protein( domain architecture ID 11469125)

ACTx2 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACTx2 COG4747
ACT domain-containing protein [General function prediction only];
2-121 1.60e-32

ACT domain-containing protein [General function prediction only];


:

Pssm-ID: 443781 [Multi-domain]  Cd Length: 129  Bit Score: 111.00  E-value: 1.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779957075   2 YDVHVIFSDRPGELARFGQLLGRNGVGLEGGGVFGTD----AHFLVEDGEKARRVLLDAGFTVqALRKPVIRKLrQERPG 77
Cdd:COG4747    1 KQISVFLENKPGRLAEVTRLLGDAGINIRALSIADTSdfgiLRLIVDDPEKAREVLKEAGFTV-SETDVLAVEL-PDRPG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 779957075  78 ELGEIAAVLAARGVSILTQYSDH-----ANHLILLTDDDKLAAEITEPW 121
Cdd:COG4747   79 GLAEILKALAEAGINIEYMYAFVgrpggKAVLILRVDDLEKAIEVLKEN 127
 
Name Accession Description Interval E-value
ACTx2 COG4747
ACT domain-containing protein [General function prediction only];
2-121 1.60e-32

ACT domain-containing protein [General function prediction only];


Pssm-ID: 443781 [Multi-domain]  Cd Length: 129  Bit Score: 111.00  E-value: 1.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779957075   2 YDVHVIFSDRPGELARFGQLLGRNGVGLEGGGVFGTD----AHFLVEDGEKARRVLLDAGFTVqALRKPVIRKLrQERPG 77
Cdd:COG4747    1 KQISVFLENKPGRLAEVTRLLGDAGINIRALSIADTSdfgiLRLIVDDPEKAREVLKEAGFTV-SETDVLAVEL-PDRPG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 779957075  78 ELGEIAAVLAARGVSILTQYSDH-----ANHLILLTDDDKLAAEITEPW 121
Cdd:COG4747   79 GLAEILKALAEAGINIEYMYAFVgrpggKAVLILRVDDLEKAIEVLKEN 127
ACT_Bt0572_1 cd04908
N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; ...
 7-61 2.07e-03

N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Included in this CD is the N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains as seen in the uncharacterized structure (pdb 2F06) of the Bt0572 protein from Bacteroides thetaiotaomicron and related ACT domains. These tandem ACT domain proteins belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153180  Cd Length: 66  Bit Score: 34.48  E-value: 2.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 779957075   7 IFSD-RPGELARFGQLLGRNGVGLEG-----GGVFGTdAHFLVEDGEKARRVLLDAGFTVQ 61
Cdd:cd04908    6 VFLEnKPGRLAAVTEILSEAGINIRAlsiadTSEFGI-LRLIVSDPDKAKEALKEAGFAVK 65
 
Name Accession Description Interval E-value
ACTx2 COG4747
ACT domain-containing protein [General function prediction only];
2-121 1.60e-32

ACT domain-containing protein [General function prediction only];


Pssm-ID: 443781 [Multi-domain]  Cd Length: 129  Bit Score: 111.00  E-value: 1.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 779957075   2 YDVHVIFSDRPGELARFGQLLGRNGVGLEGGGVFGTD----AHFLVEDGEKARRVLLDAGFTVqALRKPVIRKLrQERPG 77
Cdd:COG4747    1 KQISVFLENKPGRLAEVTRLLGDAGINIRALSIADTSdfgiLRLIVDDPEKAREVLKEAGFTV-SETDVLAVEL-PDRPG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 779957075  78 ELGEIAAVLAARGVSILTQYSDH-----ANHLILLTDDDKLAAEITEPW 121
Cdd:COG4747   79 GLAEILKALAEAGINIEYMYAFVgrpggKAVLILRVDDLEKAIEVLKEN 127
ACTx2 COG4747
ACT domain-containing protein [General function prediction only];
6-58 1.52e-03

ACT domain-containing protein [General function prediction only];


Pssm-ID: 443781 [Multi-domain]  Cd Length: 129  Bit Score: 35.89  E-value: 1.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 779957075   6 VIFSDRPGELARFGQLLGRNGVGLEGGGVFGTDAH------FLVEDGEKARRVLLDAGF 58
Cdd:COG4747   71 VELPDRPGGLAEILKALAEAGINIEYMYAFVGRPGgkavliLRVDDLEKAIEVLKENGI 129
ACT_Bt0572_1 cd04908
N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; ...
 7-61 2.07e-03

N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Included in this CD is the N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains as seen in the uncharacterized structure (pdb 2F06) of the Bt0572 protein from Bacteroides thetaiotaomicron and related ACT domains. These tandem ACT domain proteins belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153180  Cd Length: 66  Bit Score: 34.48  E-value: 2.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 779957075   7 IFSD-RPGELARFGQLLGRNGVGLEG-----GGVFGTdAHFLVEDGEKARRVLLDAGFTVQ 61
Cdd:cd04908    6 VFLEnKPGRLAAVTEILSEAGINIRAlsiadTSEFGI-LRLIVSDPDKAKEALKEAGFAVK 65
ACT_PDH-BS cd04909
C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); ...
 1-60 2.29e-03

C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); The C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH) enzyme that catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate, found in Bacillus subtilis (BS) and other Firmicutes, Deinococci, and Bacteroidetes. PDH is the first enzyme in the aromatic amino acid pathway specific for the biosynthesis of tyrosine. This enzyme is feedback-inhibited by tyrosine in B. subtilis and other microorganisms. Both phenylalanine and tryptophan have been shown to be inhibitors of this activity in B. subtilis. Bifunctional chorismate mutase-PDH (TyrA) enzymes such as those seen in Escherichia coli do not contain an ACT domain. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153181  Cd Length: 69  Bit Score: 34.52  E-value: 2.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 779957075   1 MYDVHVIFSDRPGELARFGQLLGRNGVGL---------EG-GGV----FGTDahflvEDGEKARRVLLDAGFTV 60
Cdd:cd04909    1 FYDLYVDVPDEPGVIAEVTQILGDAGISIknieileirEGiGGIlrisFKTQ-----EDRERAKEILKEAGYEV 69
ACT_Bt0572_2 cd04882
C-terminal ACT domain of a novel protein composed of just two ACT domains; Included in this CD ...
 6-60 7.65e-03

C-terminal ACT domain of a novel protein composed of just two ACT domains; Included in this CD is the C-terminal ACT domain of a novel protein composed of just two ACT domains, as seen in the yet uncharacterized structure (pdb 2F06) of the Bt0572 protein from Bacteroides thetaiotaomicron and related proteins. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153154  Cd Length: 65  Bit Score: 32.96  E-value: 7.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 779957075   6 VIFSDRPGELARFGQLLGRNGVGLE------GGGVFGTDAHFLVEDGEKARRVLLDAGFTV 60
Cdd:cd04882    4 VEVPDKPGGLHEILQILSEEGINIEymyafvEKKGGKALLIFRTEDIEKAIEVLQERGVEL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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