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Conserved domains on  [gi|798937369|ref|WP_045908281|]
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MULTISPECIES: manganese efflux pump MntP [Enterobacter]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mntp super family cl23795
Putative manganese efflux pump; MntP is a family of bacterial proteins with a signal peptide ...
1-188 3.14e-97

Putative manganese efflux pump; MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organizms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor.


The actual alignment was detected with superfamily member PRK11469:

Pssm-ID: 474059  Cd Length: 188  Bit Score: 279.54  E-value: 3.14e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   1 MNISATILLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFL 80
Cdd:PRK11469   1 MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369  81 GGRMVIEGFRGGDDEHEEPQHRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGP 160
Cdd:PRK11469  81 GGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGS 160
                        170       180
                 ....*....|....*....|....*...
gi 798937369 161 LLGKRAEILGGIVLIGIGAQILWAHFAG 188
Cdd:PRK11469 161 IIGKKAEILGGLVLIGIGVQILWTHFHG 188
 
Name Accession Description Interval E-value
PRK11469 PRK11469
manganese efflux pump MntP;
1-188 3.14e-97

manganese efflux pump MntP;


Pssm-ID: 183151  Cd Length: 188  Bit Score: 279.54  E-value: 3.14e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   1 MNISATILLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFL 80
Cdd:PRK11469   1 MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369  81 GGRMVIEGFRGGDDEHEEPQHRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGP 160
Cdd:PRK11469  81 GGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGS 160
                        170       180
                 ....*....|....*....|....*...
gi 798937369 161 LLGKRAEILGGIVLIGIGAQILWAHFAG 188
Cdd:PRK11469 161 IIGKKAEILGGLVLIGIGVQILWTHFHG 188
MntP COG1971
Putative Mn2+ efflux pump MntP [Inorganic ion transport and metabolism];
1-183 4.02e-63

Putative Mn2+ efflux pump MntP [Inorganic ion transport and metabolism];


Pssm-ID: 441574  Cd Length: 180  Bit Score: 192.63  E-value: 4.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   1 MNISATILLAFGMSMDAFAASIGKGATlhKPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFL 80
Cdd:COG1971    1 MSLLELLLLAIALSMDAFAVSIAYGLR--KKRIRIALRIALIFGLFQALMPLLGWLLGSLLSGYIGAVAHWIGFLLLILI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369  81 GGRMVIEGFRGgDDEHEEPQHRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGP 160
Cdd:COG1971   79 GLKMIYEALKE-EEEEEPKSGRISGKELLLLAIATSIDALAVGISLALLGVNILLTALLIGLVTFIMSFLGVLLGRRLGS 157
                        170       180
                 ....*....|....*....|...
gi 798937369 161 LLGKRAEILGGIVLIGIGAQILW 183
Cdd:COG1971  158 LLGKKAEILGGLILILIGLKILL 180
Mntp pfam02659
Putative manganese efflux pump; MntP is a family of bacterial proteins with a signal peptide ...
30-182 2.41e-56

Putative manganese efflux pump; MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organizms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor.


Pssm-ID: 426905  Cd Length: 152  Bit Score: 174.60  E-value: 2.41e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   30 KPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFLGGRMVIEGFRGGDDEHEEPQhRHGFWLLV 109
Cdd:pfam02659   1 KLRLRQALRIALTFGLFQALMPLIGWYLGLLFSDYIGAWDHWIAFGLLAFLGGKMIKEAFKNEEEEDLEPD-PLSGKGLL 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 798937369  110 TTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGPLLGKRAEILGGIVLIGIGAQIL 182
Cdd:pfam02659  80 LLAIATSIDALAVGVSLAFLGVNILLTALIIGIVTFIMSLLGLLLGRRLGSRLGKRAEILGGLILIGIGLKIL 152
spore_YtaF TIGR02840
putative sporulation protein YtaF; This protein family was identified, at the time of the ...
7-178 3.28e-08

putative sporulation protein YtaF; This protein family was identified, at the time of the publication of the Carboxydothermus hydrogenoformans genome, as having a phylogenetic profile that exactly matches the subset of the Firmicutes capable of forming endospores. The species include Bacillus anthracis, Clostridium tetani, Thermoanaerobacter tengcongensis, Geobacillus kaustophilus, etc. This protein, previously named YtaF, is therefore a putative sporulation protein. [Cellular processes, Sporulation and germination]


Pssm-ID: 274321  Cd Length: 206  Bit Score: 51.12  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369    7 ILLAFGMSMDAFAASIGKGatLHKPKFSeaLRTGLIFGAIETLTPLIGWGLGMLASQFV-LEWNHWIAFVLLVFLGGRMV 85
Cdd:TIGR02840   4 LLLAFAVSLDSFGVGIAYG--LRKIKIP--FLSNLIIAVISGLFIFISMLLGKFLAKFLpPKVTEILGAFILIAIGIWII 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   86 IEGFRGG------DDEHEEPQHRHGFWLLVTT-----------------------AIATSLDAMAVGVGLAFLQVNIIAT 136
Cdd:TIGR02840  80 YNAFRPKkevkdrSSEPDSTKELKSFGFVIQIlrnpevadldksgnisgkealllGIALSLDAFGAGIGASLLGLNPLAT 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 798937369  137 ALAIGCATLIMSTLGMMVGRFIGPL-LGKRAEILGGIVLIGIG 178
Cdd:TIGR02840 160 SILVAVMSFIFVSLGLFLGKKISKKsIIGKFSFLSGILLILLG 202
 
Name Accession Description Interval E-value
PRK11469 PRK11469
manganese efflux pump MntP;
1-188 3.14e-97

manganese efflux pump MntP;


Pssm-ID: 183151  Cd Length: 188  Bit Score: 279.54  E-value: 3.14e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   1 MNISATILLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFL 80
Cdd:PRK11469   1 MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369  81 GGRMVIEGFRGGDDEHEEPQHRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGP 160
Cdd:PRK11469  81 GGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGS 160
                        170       180
                 ....*....|....*....|....*...
gi 798937369 161 LLGKRAEILGGIVLIGIGAQILWAHFAG 188
Cdd:PRK11469 161 IIGKKAEILGGLVLIGIGVQILWTHFHG 188
MntP COG1971
Putative Mn2+ efflux pump MntP [Inorganic ion transport and metabolism];
1-183 4.02e-63

Putative Mn2+ efflux pump MntP [Inorganic ion transport and metabolism];


Pssm-ID: 441574  Cd Length: 180  Bit Score: 192.63  E-value: 4.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   1 MNISATILLAFGMSMDAFAASIGKGATlhKPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFL 80
Cdd:COG1971    1 MSLLELLLLAIALSMDAFAVSIAYGLR--KKRIRIALRIALIFGLFQALMPLLGWLLGSLLSGYIGAVAHWIGFLLLILI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369  81 GGRMVIEGFRGgDDEHEEPQHRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGP 160
Cdd:COG1971   79 GLKMIYEALKE-EEEEEPKSGRISGKELLLLAIATSIDALAVGISLALLGVNILLTALLIGLVTFIMSFLGVLLGRRLGS 157
                        170       180
                 ....*....|....*....|...
gi 798937369 161 LLGKRAEILGGIVLIGIGAQILW 183
Cdd:COG1971  158 LLGKKAEILGGLILILIGLKILL 180
Mntp pfam02659
Putative manganese efflux pump; MntP is a family of bacterial proteins with a signal peptide ...
30-182 2.41e-56

Putative manganese efflux pump; MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organizms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor.


Pssm-ID: 426905  Cd Length: 152  Bit Score: 174.60  E-value: 2.41e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   30 KPKFSEALRTGLIFGAIETLTPLIGWGLGMLASQFVLEWNHWIAFVLLVFLGGRMVIEGFRGGDDEHEEPQhRHGFWLLV 109
Cdd:pfam02659   1 KLRLRQALRIALTFGLFQALMPLIGWYLGLLFSDYIGAWDHWIAFGLLAFLGGKMIKEAFKNEEEEDLEPD-PLSGKGLL 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 798937369  110 TTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGPLLGKRAEILGGIVLIGIGAQIL 182
Cdd:pfam02659  80 LLAIATSIDALAVGVSLAFLGVNILLTALIIGIVTFIMSLLGLLLGRRLGSRLGKRAEILGGLILIGIGLKIL 152
spore_YtaF TIGR02840
putative sporulation protein YtaF; This protein family was identified, at the time of the ...
7-178 3.28e-08

putative sporulation protein YtaF; This protein family was identified, at the time of the publication of the Carboxydothermus hydrogenoformans genome, as having a phylogenetic profile that exactly matches the subset of the Firmicutes capable of forming endospores. The species include Bacillus anthracis, Clostridium tetani, Thermoanaerobacter tengcongensis, Geobacillus kaustophilus, etc. This protein, previously named YtaF, is therefore a putative sporulation protein. [Cellular processes, Sporulation and germination]


Pssm-ID: 274321  Cd Length: 206  Bit Score: 51.12  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369    7 ILLAFGMSMDAFAASIGKGatLHKPKFSeaLRTGLIFGAIETLTPLIGWGLGMLASQFV-LEWNHWIAFVLLVFLGGRMV 85
Cdd:TIGR02840   4 LLLAFAVSLDSFGVGIAYG--LRKIKIP--FLSNLIIAVISGLFIFISMLLGKFLAKFLpPKVTEILGAFILIAIGIWII 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 798937369   86 IEGFRGG------DDEHEEPQHRHGFWLLVTT-----------------------AIATSLDAMAVGVGLAFLQVNIIAT 136
Cdd:TIGR02840  80 YNAFRPKkevkdrSSEPDSTKELKSFGFVIQIlrnpevadldksgnisgkealllGIALSLDAFGAGIGASLLGLNPLAT 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 798937369  137 ALAIGCATLIMSTLGMMVGRFIGPL-LGKRAEILGGIVLIGIG 178
Cdd:TIGR02840 160 SILVAVMSFIFVSLGLFLGKKISKKsIIGKFSFLSGILLILLG 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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