|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
13-356 |
1.42e-119 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 351.46 E-value: 1.42e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 13 LCIDQKSFFASVSCMEKGLdPLTTKLAVVADTKRQgsvVLAATPKLKELGIKTGSRLFEIPH---RNDIYIINPSMRKYL 89
Cdd:cd01700 1 ALVDCNSFYASCERVFRPL-LLGRPLVVLSNNDGC---VIARSPEAKALGIKMGSPYFKVPDlleRHGVAVFSSNYALYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 90 NVSVAISKIALRYVPpeDLHQYSIDEFFMDVTDSYHrfNSTVFAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMDIEA 169
Cdd:cd01700 77 DMSRRIMSILERFSP--DVEVYSIDESFLDLTGSLR--FGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 170 KHTEN-GIAEWRYQDVPEKLWPIQPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANGIDQS 248
Cdd:cd01700 153 KKNPYgGVVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 249 KVrEKYKVTNPSICKSQILMRDY-QFEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAeggGIHKQYTLEEPTNLE- 326
Cdd:cd01700 233 PL-EEYPPPKKSIGSSRSFGRDVtDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTS---GFSRQPKYYSATNTLp 308
|
330 340 350
....*....|....*....|....*....|....*.
gi 802154687 327 ---RDIFKVINYFANRLCD---KKALYRTLSVSLTQ 356
Cdd:cd01700 309 yptNDTREIVKAALRLLYAiyrPGYAYRKAGVMLSD 344
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
9-418 |
1.36e-102 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 310.40 E-value: 1.36e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 9 DRDVLCIDQKSFFASVscmEKGLDP-LTTKLAVVA-DTKRQGSVVLAATPKLKELGIKTGSRLFE----IPHrndIYIIN 82
Cdd:PRK03103 2 ERVILLVDMQSFYASV---EKAANPeLKGRPVIVSgDPERRSGVVLAACPLAKAYGVKTAERLWEaqqkCPD---LVVVK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 83 PSMRKYLNVSVAISKIALRY---VPPedlhqYSIDEFFMDVTDSYHRFNSTvFAFCKRFQNEILEETGIHCTIGIGSNML 159
Cdd:PRK03103 76 PRMQRYIDVSLQITRILEDFtdlVEP-----FSIDEQFLDVTGSQKLFGSP-LEIAQKIQQRIMRETGVYARVGIGPNKL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 160 LSKVAMDIEAKHTENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMH 239
Cdd:PRK03103 150 LAKMACDNFAKKNPDGLFTLDKEDVPADLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 240 LHANGIDQSKVREKYKVTNPSICKSQILMRDYQ-FEESKVVMQELIEDVASRLRAEKKLARTIHFSF---GYAEGGGIHK 315
Cdd:PRK03103 229 RTANGIDYSPVTPHSLDRQKAIGHQMTLPRDYRgFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLrgaDFDWPTGFSR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 316 QYTLEEPTNLERDIFKVINYFANRLCDKKALyRTLSVSLTQFIKESDRQLNLFiDEYERKkdEKLAKTIDHLHLKYGKGI 395
Cdd:PRK03103 309 QMTLPEPTNLAMEVYEAACKLFHRHWDGKPV-RRVGVTLSNLVSDDVWQLSLF-GDRERK--RSLGYVMDDIKNRFGPTA 384
|
410 420
....*....|....*....|...
gi 802154687 396 VSKATSYTEAGTKHGRLGLMAGH 418
Cdd:PRK03103 385 ILRASSLTEAGQAFERAAKIGGH 407
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
10-355 |
1.84e-75 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 238.12 E-value: 1.84e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 10 RDVLCIDQKSFFASVscmEKGLDP-LTTK-LAVVADTKRqgSVVLAATPKLKELGIKTGSRLFEIPHR-NDIYIINPSMR 86
Cdd:COG0389 1 RRILHVDMDAFYASV---EQRDRPeLRGKpVAVGGDNNR--GVVAAASYEARAFGVRSGMPLFQARRLcPDLVVLPPDFE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 87 KYLNVSVAISKIALRYVPpeDLHQYSIDEFFMDVTDSYHRFNSTVfAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMD 166
Cdd:COG0389 76 LYRDVSRRVMAILERYTP--LVEPLSIDEAFLDVTGSARLFGSAE-AIARRIRRRIRRETGLTVSVGIAPNKFLAKIASD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 167 IeAKhtENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANGID 246
Cdd:COG0389 153 L-AK--PDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGID 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 247 QSKVREKYKVtnPSICKSQILMRD-YQFEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQYTLEEPTNL 325
Cdd:COG0389 229 PRPVEPRRPR--KSIGVERTFGEDlTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDD 306
|
330 340 350
....*....|....*....|....*....|
gi 802154687 326 ERDIFKVINYFANRLCDKKALYRTLSVSLT 355
Cdd:COG0389 307 TAELLRAARELLERIYRPGRPVRLLGVRLS 336
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
10-409 |
5.35e-65 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 213.35 E-value: 5.35e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 10 RDVLCIDQKSFFASVscmEKGLDP-LTTK-LAVVADTKRQGSVVLAATPKLKELGIKTGSRLFEIPHR-NDIYIINPSMR 86
Cdd:PRK01810 5 RVIFHVDMNSFFASV---EIAYDPsLQGKpLAVAGNEKERKGIIVTCSYEARAYGIRTTMPLWEAKRLcPQLIVRRPNFD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 87 KYLNVSVAISKIALRYVPPedLHQYSIDEFFMDVTDSYHRFNSTVFAfcKRFQNEILEETGIHCTIGIGSNMLLSKVAMD 166
Cdd:PRK01810 82 RYREASRQMFQILSEFTPL--VQPVSIDEGYLDITDCYALGSPLEIA--KMIQQRLLTELQLPCSIGIAPNKFLAKMASD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 167 IEAKhteNGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANGID 246
Cdd:PRK01810 158 MKKP---LGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGID 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 247 QSKVR----EKYKvtnpSICKSQILMRDYQFE-ESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQYTLEE 321
Cdd:PRK01810 234 DRPVDpeaiYQFK----SVGNSTTLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 322 PTNLERDIFKVinyfANRLCDK---KALYRTLSVSLTQFI--KESDRQLNLFidEYERK-KDEKLAKTIDHLHLKYGKGI 395
Cdd:PRK01810 310 PIWEKRDIFQA----ASRLFKQhwnGDPVRLLGVTATDLEwkTEAVKQLDLF--SFEEDaKEEPLLAVIDQINDKYGMPL 383
|
410
....*....|....
gi 802154687 396 VSKATSYTEAGTKH 409
Cdd:PRK01810 384 LQRGSQLLRKQEKT 397
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
13-357 |
3.88e-63 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 206.22 E-value: 3.88e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 13 LCIDQKSFFASVscmEKGLDP-LTTK-LAVVADTKRqgSVVLAATPKLKELGIKTGSRLFE----IPHrndIYIINPSMR 86
Cdd:cd03586 1 IHIDMDAFYASV---EQRDNPeLKGKpVAVGGSSDR--GVVSTASYEARKFGVRSAMPIFQakklCPN---LIFVPPRFD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 87 KYLNVSVAISKIALRYVPpeDLHQYSIDEFFMDVTDSYHRFNStVFAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMD 166
Cdd:cd03586 73 KYREVSRQIMEILREYTP--LVEPLSIDEAYLDVTDYVRLFGS-ATEIAKEIRARIREETGLTASAGIAPNKFLAKIASD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 167 IeAKhtENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANGID 246
Cdd:cd03586 150 L-NK--PNGLTVIPPEDVEEFLAPL-PVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGID 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 247 QSKV--REKYKvtnpSICKSQILMRD-YQFEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQYTLEEPT 323
Cdd:cd03586 226 NRPVepDRERK----SIGVERTFSEDlTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPT 301
|
330 340 350
....*....|....*....|....*....|....
gi 802154687 324 NLERDIFKVINYFANRLCDKKAlYRTLSVSLTQF 357
Cdd:cd03586 302 DDAEDIYELALELLEELLDGRP-IRLLGVRLSGL 334
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
15-166 |
3.07e-43 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 148.49 E-value: 3.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 15 IDQKSFFASVscmEKGLDP-LTTKLAVVADTKRQGsVVLAATPKLKELGIKTGSRLFEIPHR-NDIYIINPSMRKYLNVS 92
Cdd:pfam00817 1 IDMDAFFASV---ELLRDPeLKGKPVAVGGGNGRG-IVAAASYEARKYGVRSGMPVFEAKKLcPNLIVVPPDLELYRRAS 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 802154687 93 VAISKIALRYVPPeDLHQYSIDEFFMDVTDSYHRFNSTVfAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMD 166
Cdd:pfam00817 77 RKIFEILRRFSTP-KVEQASIDEAFLDLTGLEKLFGAEE-ALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
77-369 |
1.78e-30 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 119.84 E-value: 1.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 77 DIYIINPSMRKYLNVSVAISKIALRYVPP-EDLhqySIDEFFMDVTDSYHRFNS-TVFAfcKRFQNEILEETGIHCTIGI 154
Cdd:PRK02406 60 DLIFVPGRFDVYKEVSRQIREIFRRYTDLiEPL---SLDEAYLDVTDNKLCIGSaTLIA--QEIRQDIFEELGLTASAGV 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 155 GSNMLLSKVAMDIeakHTENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVL 234
Cdd:PRK02406 135 APNKFLAKIASDW---NKPNGLFVITPEEVDAFLATL-PVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKF 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 235 GIDMHLHANGIDQSKV---REKyKvtnpSICKSQILMRD-YQFEESKVVMQELIEDVASRLRAEKKLARtihfsfgyaeg 310
Cdd:PRK02406 211 GRRLYERARGIDERPVkpdRER-K----SVGVERTFAEDlYDLEACLAELPRLAEKLERRLERAKPDKR----------- 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 802154687 311 ggIHKQY-----------TLE---EPTNLERDIFKVINYFANRLCDKKalYRTLSVSLTQFIKESDRQLNLFI 369
Cdd:PRK02406 275 --IKTVGvklkfadfqqtTKEhtaDPLDKADLIELLAQALLRRLGGRG--VRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
13-311 |
1.64e-26 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 108.99 E-value: 1.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 13 LCIDQKSFFASVscmEKGLDPLTTK--LAVVADTKRQGSVVlAATPKLKELGIKTGSRLFEIphRN---DIYIINPSMRK 87
Cdd:cd00424 1 LHIDFDNFFASV---EQLARPELKGrpVVVVPFNSDSTCVI-ACSYEARKYGVKRGMPVREA--RKmcpNLILVPARLDL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 88 YLNVSVAISKIALRYVPPEDLhqYSIDEFFMDVTDSYHRFNSTvFAFCKRFQNEILEETG-IHCTIGIGSNMLLSKVAMD 166
Cdd:cd00424 75 YRRLSERLLSELEEVAPLVEV--ASIDELFLDLTGSARLLGLG-SEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 167 IeAKhtENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRD-FGVLGIDMHLHANGI 245
Cdd:cd00424 152 Y-AK--PDGLTILDPEDLPGFLSKL-PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALwGGVSGERLWYALRGI 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 802154687 246 DQSKVREKYKVtnPSICKSQILMRDYQ-FEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGG 311
Cdd:cd00424 228 DDEPLSPPRPR--KSFSHERVLPRDSRnAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGR 292
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
9-332 |
1.17e-23 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 100.95 E-value: 1.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 9 DRDVLCIDQKSFFASVSCMEkglDP-LTTKLAVVADTKRQGsVVLAATPKLKELGIKTGSRLFEIPHR--NDIYIinPSM 85
Cdd:PRK14133 2 DRVIIHVDMDAFFASVEQMD---NPkLKGKPVIVGGISERG-VVSTCSYEARKYGVHSAMPVFMAKKRcpHGIFL--PVR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 86 R-KYLNVSVAISKIALRYVPPedLHQYSIDEFFMDVTDsyhrFNSTVFAFCKRFQNEILEETGIHCTIGIGSNMLLSKVA 164
Cdd:PRK14133 76 HeRYKEVSKNIFKILYEVTPI--VEPVSIDEAYLDITN----IKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 165 MDIeakHTENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANG 244
Cdd:PRK14133 150 SDW---NKPDGIKIITEDMIPDILKPL-PISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 245 IDQSKV---REKykvtnPSICKSQILMRDY-QFEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQYTLE 320
Cdd:PRK14133 226 IDYREVevsRER-----KSIGKETTLKKDTkDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLN 300
|
330
....*....|..
gi 802154687 321 EPTNLERDIFKV 332
Cdd:PRK14133 301 DYIRDKEEIYNV 312
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
15-403 |
1.55e-22 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 98.85 E-value: 1.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 15 IDQKSFFASVscmEKGLDP-LTTKLAVVADTKRqgSVVLAATPKLKELGIKTGSRLFE----IPhrnDIYIINPSMRKYL 89
Cdd:PRK02794 41 IDCDAFYASV---EKRDNPeLRDKPVIIGGGKR--GVVSTACYIARIHGVRSAMPMFKalklCP---DAVVIKPDMEKYV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 90 NVSVAISKIALRYVPpeDLHQYSIDEFFMDVTDS---YHRFNSTVFAfckRFQNEILEETGIHCTIGIGSNMLLSKVAMD 166
Cdd:PRK02794 113 RVGREVRAMMQALTP--LVEPLSIDEAFLDLSGTerlHGAPPAVVLA---RFARRVEREIGITVSVGLSYNKFLAKIASD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 167 IEAKHTENGIAEwryQDVPEKLWPiQPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANGID 246
Cdd:PRK02794 188 LDKPRGFSVIGR---AEALAFLAP-KPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGID 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 247 QSKVrekykvtNP-----SICKSQILMRD-YQFEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQYTLE 320
Cdd:PRK02794 264 DRKV-------SPdreakSVSAETTFETDlSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLE 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 321 EPTNLERDIFKVinyfANRLCDKKA---LYRTLSVSLTQFIKESDRQLNLFIDEYERKKdEKLAKTIDHLHLKYGKGIVS 397
Cdd:PRK02794 337 DPTQLADRIFRT----ARELLEKETdgtAFRLIGIGVSDLSPADEADPPDLLDPQATRR-AAAERAIDALRAKFGAAAVE 411
|
....*.
gi 802154687 398 KATSYT 403
Cdd:PRK02794 412 TGRALR 417
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
13-396 |
2.77e-22 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 97.91 E-value: 2.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 13 LCiDQKSFFASvsCmEKGLDPLTTKLAVVADTKRQGSVVlAATPKLKELGIKTGSRLFEIP---HRNDIYIINPSMRKYL 89
Cdd:PRK03609 4 LC-DVNSFYAS--C-ETVFRPDLRGKPVVVLSNNDGCVI-ARSAEAKALGIKMGDPWFKQKdlfRRCGVVCFSSNYELYA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 90 NVSVAISKIaLRYVPPEdLHQYSIDEFFMDVTDSYHRFNSTVFAfcKRFQNEILEETGIHCTIGIGSNMLLSKVAMDIEA 169
Cdd:PRK03609 79 DMSNRVMST-LEELSPR-VEIYSIDEAFCDLTGVRNCRDLTDFG--REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 170 KHTEN--GIAEWRYQDVPEKLWPIQPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHLHANGIDQ 247
Cdd:PRK03609 155 KWQRQtgGVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPC 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 248 SKVREKYKVTNPSICKSQILMRDYQFEESKVVMQELIEDVASRLRAEKKLARTIHfSFGYAEGGGIHKQY-------TLE 320
Cdd:PRK03609 235 LSLEEFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFIS-TFVKTSPFALNEPYygnsasvKLL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 802154687 321 EPTNLERDIFKVINYFANRLCDKKALYRTLSVSLTQFIKESDRQLNLFIDEYERKKDEKLAKTIDHLHLKYGKGIV 396
Cdd:PRK03609 314 TPTQDSRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNAKSGKGTL 389
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
16-400 |
1.17e-20 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 93.13 E-value: 1.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 16 DQKSFFASVscmEKGLDP-LTTKLAVVAdtkrqGSVVLAATPKLKELGIKTGsrlfeIPHRN------DIYIINPSMRKY 88
Cdd:PRK03858 10 DLDSFYASV---EQRDDPaLRGRPVIVG-----GGVVLAASYEAKAYGVRTA-----MGGRQarrlcpQAVVVPPRMSAY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 89 LNVSVAISKIaLRYVPP--EDLhqySIDEFFMDVTDSyHRFNSTVFAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMD 166
Cdd:PRK03858 77 SRASKAVFEV-FRDTTPlvEGL---SIDEAFLDVGGL-RRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 167 iEAKhtENGIAEwryqdVP-----EKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRdfgVLGIDM--H 239
Cdd:PRK03858 152 -VAK--PDGLLV-----VPpdrelAFLHPL-PVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVS---LLGPAAgrH 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 240 LHA--NGIDQSKVREkyKVTNPSICKSQILMRDYQFEES-KVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQ 316
Cdd:PRK03858 220 LHAlaHNRDPRRVET--GRRRRSVGAQRALGRGPNSPAEvDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 317 YTLEEPTN-----LE--RDIFKVinyfANRLCDKKALyrTL-SVSLTQFIKESDRQLNLFIDeyERKKDEKLAKTIDHLH 388
Cdd:PRK03858 298 HTLPRPTAstatlLAaaRDLVAA----AAPLIAERGL--TLvGFAVSNLDDDGAQQLELPFG--LRRPGSALDAALDAVR 369
|
410
....*....|..
gi 802154687 389 LKYGKGIVSKAT 400
Cdd:PRK03858 370 DRFGNAAVTRAV 381
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
9-301 |
9.26e-17 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 81.59 E-value: 9.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 9 DRDVLCIDQKSFFASVScMEKGLDpLTTKLAVVADTKRQGSVVLAATPKLKELGIKTG----------SRLFEIPHRNDi 78
Cdd:cd01701 46 QRIIMHVDFDCFFVSVS-IRNRPD-LKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGmwvgqakklcPQLVTLPYDFE- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 79 yiinpsmrKYLNVSVAISKIALRYVppEDLHQYSIDEFFMDVTDSYHRFNSTVFAFCKRFQNEILEETGIHCTIGIGSNM 158
Cdd:cd01701 123 --------AYEEVSLTFYEILASYT--DNIEAVSCDEALIDITSLLEETYELPEELAEAIRNEIRETTGCSASVGIGPNI 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 159 LLSKVAMDiEAKhtENGIAEWRYQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGIFTIGD--LAKYPYHYLKRDFGV-LG 235
Cdd:cd01701 193 LLARLATR-KAK--PDGQYHLSAEKVEEFLSQL-KVGDLPGVGSSLAEKLVKLFGDTCGGleLRSKTKEKLQKVLGPkTG 268
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 802154687 236 IDMHLHANGIDQSKVrEKYKVTNPSICKSQILMRDYQFEESKVVMQELIEDVASRLRAEKKLARTI 301
Cdd:cd01701 269 EKLYDYCRGIDDRPV-TGEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQI 333
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
108-301 |
1.07e-16 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 81.52 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 108 LHQYSIDEFFMDVTDSYHRFNSTVFAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMDiEAKhtENGIAEWRYQDVPEK 187
Cdd:PRK03348 100 VEQLSFDEAFVEPAELAGASAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASG-LAK--PDGIRVVPPGEEREL 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 188 LWPIqPLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFG-VLGIDMHLHANGIDQSKV---REKYKVTNPSICK 263
Cdd:PRK03348 177 LAPL-PVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGaTVGPALHRLARGIDDRPVaerAEAKQISAESTFA 255
|
170 180 190
....*....|....*....|....*....|....*...
gi 802154687 264 SQILMRDyqfeESKVVMQELIEDVASRLRAEKKLARTI 301
Cdd:PRK03348 256 VDLTTRA----QLREAIERIAEHAHRRLLKDGRGARTV 289
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
12-232 |
1.91e-15 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 77.14 E-value: 1.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 12 VLCIDQKSFFASVscmEKGLDP-LTTKLAVV----ADTKRQGSVVlAATPKLKELGIKTG---SRLFEIPhRNDIYIinp 83
Cdd:PRK01216 3 ILFVDFDYFFAQV---EEVLNPsLKGKPVVVcvysGRFEDSGAVA-TANYEARKLGIKAGmpiVEAKKIL-PNAVYL--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 84 SMRK--YLNVSVAISKIALRYvpPEDLHQYSIDEFFMDVTDSYHRFNSTVfAFCKRFQNEILEETGIHCTIGIGSNMLLS 161
Cdd:PRK01216 75 PMRKevYQQVSNRIMKLLREY--SEKIEIASIDEAYLDISDKVKNYQDAY-NLGLEIKNKILEKEKITVTVGISKNKVFA 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 802154687 162 KVAMDieaKHTENGIAEWRYQDVPEKLWPIQpLRDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFG 232
Cdd:PRK01216 152 KIAAD---MAKPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIG 218
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
132-324 |
2.23e-14 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 73.90 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 132 FAFCKRFQNEILEETGIHCTIGIGSNMLLSKVAMDIeAKhtENGIaeWRYQDvpEKLWPI---QPLRDFWGINKRTEKKL 208
Cdd:PRK03352 121 EALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGF-AK--PAGV--FRLTD--ANWMAVmgdRPTDALWGVGPKTAKRL 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 209 NKRGIFTIGDLAKYPYHYLKRDFG-VLGIDMHLHANGIDQSKVREKykvtnPSICKSQILMRDYQ---------FEESKV 278
Cdd:PRK03352 194 AALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSAE-----PWVPRSRSREVTFPqdltdraevESAVRE 268
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 802154687 279 VMQELIEDVASRLRAEKKLARTIHFSFGYAEGggihKQYTLEEPTN 324
Cdd:PRK03352 269 LARRVLDEVVAEGRPVTRVAVKVRTATFYTRT----KIRKLPEPTT 310
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
260-361 |
8.23e-13 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 64.12 E-value: 8.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 260 SICKSQILMRDY-QFEESKVVMQELIEDVASRLRAEKKLARTIHFSFGYAEGGGIHKQYTLEEPTNLERDIFKVinyfAN 338
Cdd:pfam11799 3 SIGAERTFGRDLtDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRA----AL 78
|
90 100
....*....|....*....|....*.
gi 802154687 339 RLCDK---KALYRTLSVSLTQFIKES 361
Cdd:pfam11799 79 RLLRRlyrGRPVRLLGVSLSNLVPEG 104
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
38-301 |
1.60e-09 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 58.93 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 38 LAVVADTKRQgsVVLAATPKLKELGIKTGSRLFE----IPHRNDIYIINPSMRKYLNvsvAISKIALRYVPPEDLHQYsi 113
Cdd:cd03468 25 LAVVERKKAG--RILACNAAARAAGVRPGMPLAEalalCPNLQVVEYDPEADARALQ---ELALWLLRFTPLVALDGP-- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 114 DEFFMDVTDSYHRFNSTVfAFCKRFQNEiLEETGIHCTIGIGSNMLLSKV-AMDIEAKHTENGIAEWRYQDVPEKLwPIq 192
Cdd:cd03468 98 DGLLLDVTGCLHLFGGED-ALAASLRAA-LATLGLSARAGIADTPGAAWLlARAGGGRGVLRREALAAALVLLAPL-PV- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 193 plrDFWGINKRTEKKLNKRGIFTIGDLAKYPYHYLKRDFGVLGIDMHlhangiDQSKVREKYKVTNPSICKSQILMRDYQ 272
Cdd:cd03468 174 ---AALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRL------DQAYGRDPEPLLFSPPPPAFDFRLELQ 244
|
250 260 270
....*....|....*....|....*....|....
gi 802154687 273 FEE-----SKVVMQELIEDVASRLRAEKKLARTI 301
Cdd:cd03468 245 LEEpiargLLFPLRRLLEQLCAFLALRGLGARRL 278
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
181-213 |
1.82e-07 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 47.01 E-value: 1.82e-07
10 20 30
....*....|....*....|....*....|...
gi 802154687 181 YQDVPEKLWPIqPLRDFWGINKRTEKKLNKRGI 213
Cdd:pfam11798 1 PDDVPEFLWPL-PISKIPGIGKKLAEKLKALGI 32
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
16-301 |
1.09e-05 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 47.08 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 16 DQKSFFASVsCMEKglDP-LTTK-LAVvadtkRQGSVVLAATPKLKELGIKtgsRLFEI-------PhrnDIYIIN-PSM 85
Cdd:cd01703 4 DLDCFYAQV-EEIR--DPsLKSKpLGI-----QQKYIVVTCNYEARRLGVK---KLMSIkdakeicP---DLVLVNgEDL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 86 RKYLNVSVAISKIALRYVPPEDLHQYSIDEFFMDVTDsYHRFNSTVFAFckRFQNEILEETGIHCTIGIGSNMLLSKVAM 165
Cdd:cd01703 70 TPFRDMSKKVYRLLRSYSWNDRVERLGFDENFMDVTE-MRLLVASHIAY--EMRERIENELGLTCCAGIASNKLLAKLVG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 166 DIEAKHTENGIAEWRYQDVPEKLWPIQpLRDFWGINKRTEKKLNKRGIFTIGDLAKYPY----------HYLKRDFGVLG 235
Cdd:cd01703 147 SVNKPNQQTTLLPPSCADLMDFMDLHD-LRKIPGIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapSLLELLLMVKE 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 236 ----IDMHLH--ANGIDQSKVRE------------KYK---VTNPSICKSQILMRDYQFEESkvVMQELIEDVASRLRAE 294
Cdd:cd01703 226 fgegIGQRIWklLFGRDTSPVKPasdfpqqisiedSYKkcsLEEIREARNKIEELLASLLER--MKQDLQEVKAGDGRRP 303
|
....*..
gi 802154687 295 KKLARTI 301
Cdd:cd01703 304 HTLRLTL 310
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
112-253 |
6.83e-05 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 44.61 E-value: 6.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 112 SIDEFFMDVTdsyhrfnSTVfafCKRFQNEILEETGIHCTIGIGSNMLLSKVAmdiEAKHTENGIAEWRYQDVPEKLWPI 191
Cdd:cd01702 116 SIDEAYLDLG-------SRI---VEEIRQQVYDELGYTCSAGIAHNKMLAKLA---SGMNKPNAQTILRNDAVASFLSSL 182
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 802154687 192 qPLRDFWGI-NKRTEKKLNKRGIFTIGDLAKY---PYHYLKRDFGVLGIDMHLHANGIDQSKVREK 253
Cdd:cd01702 183 -PITSIRGLgGKLGEEIIDLLGLPTEGDVAGFrssESDLQEHFGEKLGEWLYNLLRGIDHEPVKPR 247
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
15-219 |
9.70e-05 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 44.62 E-value: 9.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 15 IDQKSFFASVScMEKGLDPLTTKLAVVADTKRQGSVVLAatpklKELGIKTGSRLF-EIPHRNDIYIINPSMRKYLNVSV 93
Cdd:PTZ00205 138 LDMDMFYAAVE-IKKHPEYAAIPLAIGTMTMLQTANYVA-----RGRGIRQGMPGFlALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802154687 94 AISKIALRYVPpeDLHQYSIDEFFMDVTDSYHRFNSTVFA--FCKRFQNEILEETGIHCTIGIGSNMLLSKVAMDIEAKH 171
Cdd:PTZ00205 212 TVRRIVAEYDP--NYISFGLDELTLEVSAYIERFEGTKTAedVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPN 289
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 802154687 172 TENGIAEWRYQDVPEKLWPIQpLRDFWGINKRTEKKLNKRGIFTIGDL 219
Cdd:PTZ00205 290 GQHDLNLHTRGDVMTYVRDLG-LRSVPGVGKVTEALLKGLGITTLSDI 336
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
192-229 |
3.04e-03 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 40.03 E-value: 3.04e-03
10 20 30
....*....|....*....|....*....|....*....
gi 802154687 192 QPLRDFWGINKRTEKKLNKRGIFTIGDLAKY-PYHYLKR 229
Cdd:COG1200 6 TPLTYLKGVGPKRAKLLAKLGIRTVGDLLFHlPRRYEDR 44
|
|
| |
