|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
14-385 |
0e+00 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 545.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 14 IAGILVFATNLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIAL 93
Cdd:cd17409 1 IAGILLIAANLRAPFTGVAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 94 RSTGPSWALFVGTAVLGGGIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLY--AFNWQVSLGAFL 171
Cdd:cd17409 81 RSTGSVWALYLGTAIIGAGIAIGNVLLPSLLKRDFPARVATLTGAYALTMGVGAALGSALVVPLAQvlAFGWQLALGAFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 172 VLPIVSALIWLPQLRRHSRPSADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGT 251
Cdd:cd17409 161 VFPLVAALIWLPQLRRHTSPAADTAKPPHGGSVWRSPLAWQVTLFLGLNSFIYYVLVGWLPSILTDAGYSAAQAGSLHGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 252 MQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQTA 331
Cdd:cd17409 241 LQLATAVPGLLLIPVLARMKDQRLLAVLVSLLGAVGLIGLLLAPSLAILWVILFGFGSGAGFILGLAFIGLRTSSAHQAA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 806506617 332 SLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGLGAGR 385
Cdd:cd17409 321 ALSGMAQCVGYLLAATGPMLVGALHDLTGSWSVPLLLCAALALLMAIFGLLAGR 374
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
14-385 |
3.67e-121 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 356.12 E-value: 3.67e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 14 IAGILVFATNLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIAL 93
Cdd:cd17339 1 ILGIVLIAFNLRPAITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 94 RSTGPSWALFVGTAVLGGGIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPL--LYAFNWQVSLGAFL 171
Cdd:cd17339 81 RSLGGIALLFLGTALAGAGIAVGNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLaqALGGGWRGALAIWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 172 VLPIVSALIWLPQLRRHSRPSAdTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGT 251
Cdd:cd17339 161 LPALLALLIWLPQLRRRKRAAA-AAAPLTKISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 252 MQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLI-AIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQT 330
Cdd:cd17339 240 FQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTAlALLWAVLLGLGGGAAFSLALTLISLRSSDPAEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 806506617 331 ASLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGLGAGR 385
Cdd:cd17339 320 AALSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLGAGR 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-386 |
3.93e-113 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 336.46 E-value: 3.93e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 2 SASHRRLHPAWIIAGILVFATNLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALF 81
Cdd:COG2807 8 ARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 82 AALIVMAGGIALRSTGPS-WALFVGTAVLGGGIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYA 160
Cdd:COG2807 88 LALLLLAAGLLLRSLAPSvALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 161 FNWQVSLGAFLVLPIVSALIWLPQLRRHSRPSADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGY 240
Cdd:COG2807 168 LGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 241 TQGEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIA-IVWVSLFGFGIGGAFIVALAF 319
Cdd:COG2807 248 SAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLpWLWAVLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 806506617 320 IGLRTSSAQQTASLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGLGAGRA 386
Cdd:COG2807 328 IGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| CynX |
TIGR00896 |
cyanate transporter; This family of proteins is involved in active transport of cyanate. The ... |
13-363 |
2.11e-98 |
|
cyanate transporter; This family of proteins is involved in active transport of cyanate. The cyanate transporter in E.Coli is used to transport cyanate into the cell so it can be metabolized into ammonia and bicarbonate. This process is used to overcome the toxicity of environmental cyanate. [Transport and binding proteins, Other]
Pssm-ID: 129974 Cd Length: 355 Bit Score: 297.44 E-value: 2.11e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 13 IIAGILVFATNLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIA 92
Cdd:TIGR00896 1 LILGIVLIALNLRPALTSVGPLLPQIRSALGMSFSVAGLLTALPVLCFAVLAPLAPWLARRFGEERSVAAGLLLIAAGIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 93 LRSTGPSWALFVGTAVLGGGIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFN--WQVSLGAF 170
Cdd:TIGR00896 81 IRSAPGTALLFAGTALIGVGIAIINVLLPSLIKRDFPQRVGLMTGLYSMALMGGAALAAAATVPLAQHSGghWQQALAWW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 171 LVLPIVSALIWLPQLRRHSRPSADTAAPPHGGpIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHG 250
Cdd:TIGR00896 161 ALPALLALLAWIPQVRRRVAANQTTTRLTPVR-IWRSPLAWQVTVFFGLQSGLYYSLIGWLPAILISHGASAATAGSLLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 251 TMQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIV-WVSLFGFGIGGAFIVALAFIGLRTSSAQQ 329
Cdd:TIGR00896 240 LMQLAQAASALLIPALARRVKDQRGIVAVLAVLQLVGLCGLLFAPMHGLWaWALVLGLGQGGAFPLALTLIGLRSRQAAQ 319
|
330 340 350
....*....|....*....|....*....|....
gi 806506617 330 TASLSGMTQSIGYLMSATGPVLVGLLHDATNDWS 363
Cdd:TIGR00896 320 AAALSAMAQSIGYLLAALGPLFVGVLHDISGNWL 353
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
17-381 |
4.71e-48 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 167.59 E-value: 4.71e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 17 ILVFATNLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRST 96
Cdd:cd17410 4 IVLLGLNLRPILTSVGPLLNEIRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 97 GPSWALFVGTAVLGG-GIAIGNTLLPSLIKRDFPSQITKLTAIYSVTM---GVVSAVGSAMVVPllYAFNWQVSLGAFLV 172
Cdd:cd17410 84 SGTGPTLIASALLGGlGIAIIQALVPGLIKRRFPARVPLAMGLYSASLmagGGLAASLSPRLAQ--HSAGWQLGLGIWAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 173 LPIVSALIWLPQLRRHSRPSADTAAPPHggpIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTM 252
Cdd:cd17410 162 PALVALVLWWRQPPREVAPSDTAGPGVR---FFRNRRAWLLALYFGLINAGYTSMIAWLPAYYLELGWSAQDSGSLLGFM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 253 QLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPL-IAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQTA 331
Cdd:cd17410 239 TIFQVLGALVMPALARRSADRRPLLMGALAAQLAGFLGLILMPQsLPLLWVALIGLGLGACFSLGLILALDHLRKPRAAG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 806506617 332 SLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd17410 319 QLAAFVQGIGFIITGISPWIAGWLRDSTGSFQAAWLLLAASVVAMLLLTL 368
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
23-363 |
1.71e-36 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 137.25 E-value: 1.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 23 NLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWAL 102
Cdd:PRK09705 20 NMRPLLTSVGPLLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSAL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 103 FVGTAVLGG-GIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLL-YAFNWQVSLGAFLVLPIVSALI 180
Cdd:PRK09705 100 LLSSALLGGvGIGIIQAVMPSVIKRRFQQRTPLVMGLWSAALMGGGGLGAAITPWLVqHSETWYQTLAWWALPAVVALFA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 181 WLPQLRRHSRPSADTAAPPHGgpIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALpG 260
Cdd:PRK09705 180 WWWQSAREVASSHKTTTTPVR--VVFTPRAWTLGVYFGLINGGYASLIAWLPAFYIEIGASAQYSGSLLALMTLGQAA-G 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 261 LLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPL-IAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQTASLSGMTQS 339
Cdd:PRK09705 257 ALLMPAMARHQDRRKLLMLALVLQLVGFCGFIWLPLqLPVLWAMVCGLGLGGAFPLCLLLALDHSVQPAIAGKLVAFMQG 336
|
330 340
....*....|....*....|....
gi 806506617 340 IGYLMSATGPVLVGLLHDATNDWS 363
Cdd:PRK09705 337 IGFIIAGLAPWFSGVLRSISGNYL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-381 |
3.84e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.96 E-value: 3.84e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 11 AWIIAGILVFATNLR-GPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAG 89
Cdd:COG2223 3 RWRVLLLATLAFFLAfGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 90 GIALRSTGPSWALFVGTAVLGGGIAIGN--TLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSL 167
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSfaVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 168 GAFLVLPIVSALIWLPQLRRHSRPSADTAAPPHGGP--IWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGE 244
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQleALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 245 AGSLHGTMqlasALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPL------IAIVWVSLFGFGIGGAFIVALA 318
Cdd:COG2223 243 AGLLAALF----ALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALalgslwLFLVLFLLLGLALGGGNGAVFA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806506617 319 FIGlRTSSAQQTASLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:COG2223 319 LVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
10-379 |
4.32e-22 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 96.96 E-value: 4.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 10 PAWIIAGILVFATNLRGPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAG 89
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 90 GIALRSTGPSWALFVGTAVLGGGIAIGNTLLP---SLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVS 166
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVafaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 167 LGAFLVLPIVSALIWLPQLRRHSRPSADTAAPPHGGP--------IWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDL 238
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAspgstlkeALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 239 GYTQGEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVGLAL--AGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVA 316
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALraLGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806506617 317 LAFIGLRTSSAQQtASLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGV 379
Cdd:cd17355 321 AALAARYFGARSY-GTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-387 |
1.45e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.94 E-value: 1.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 4 SHRRLHPAWIIAGILVFATNLRGP-FTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFA 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLdRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 83 ALIVMAGGIALRSTGPS-WALFVGTAVLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYA 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSfWQLLLLRFLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 161 FNWQVSLGAFLVLPIVSALIWLpqlrrhsrpsadtaapphggpiwrsplaWQVTLFFGINSFVYYAVAAWLPSILVD-LG 239
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRF----------------------------WLLALAYFLVYFALYGFLTWLPTYLVEvRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 240 YTQGEAGSLHGTMQLASALPGLLIVPIVQRA-RDQRGLAVGLALAGLVSLIGLKLFP--LIAIVWVSLFGFGIGGAFIVA 316
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPspALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 806506617 317 LAFIGlRTSSAQQTASLSGMTQSIGYLMSATGPVLVGLLHDATNdWSTVLMVCMAMCVVLAGVGLGAGRAI 387
Cdd:COG2271 293 WALAA-ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRET 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-346 |
3.78e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 90.80 E-value: 3.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 1 MSASHRRLHPAWIIAGILVFATNLrgPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERAL 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGL--GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 81 FAALIVMAGGIALRSTGPS-WALFVGTAVLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLL 158
Cdd:COG2814 79 LLGLLLFALGSLLCALAPSlWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 159 YAFNWQVSLGAFLVLPIVSALIWLPQLRRhSRPSADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD- 237
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEv 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 238 LGYTQGEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVGLALAGL-VSLIGLKLFPLIAIVWVSLFGFGIGGAFIVA 316
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALgLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|
gi 806506617 317 LAFIgLRTSSAQQTASLSGMTQSIGYLMSA 346
Cdd:COG2814 318 QALV-AELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
29-381 |
7.81e-19 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 87.24 E-value: 7.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSE-AGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMA--GGIALRSTGPsWALFVG 105
Cdd:cd17473 16 AAIAPALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGigGVAGLFLDSL-YALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 106 TAVLGGGIAIGNTLLPSLIKrDFPSQITKLTAI-YSVTMGVVSAVGSAMVVPLLYAFNWQ----VSLGAFLVLPIVSALI 180
Cdd:cd17473 95 RALLGIGVAGIMTLATALIG-DYFEGEERAKMLgLQSAAMSLGGVVFLLLGGALAEIGWRapflVYLLALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 181 WLPQLRRHSRPSADTAAPPhgGPIWRSPLAWQVTLFFGinSFVYYAVAAWLPSILVDLGYT-QGEAGSLHGTMQLASALP 259
Cdd:cd17473 174 PEPARKSKSAASPGAATAA--ALPWKRVLPIYFLAFLA--MLLFYVIPIQLPFLLQERGGGsAALIGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 260 GLLIVPIVQRARDQRGLAVGLALAGL-VSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQTASLSGMTQ 338
Cdd:cd17473 250 ALLFGRLKRRLGKRRLLAIGFALMALgFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 806506617 339 SIgYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd17473 330 AF-FLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
4-386 |
2.13e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.06 E-value: 2.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 4 SHRRLHPAWIIAGILVFATNLrgPFTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAA 83
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGF--ATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 84 LIVMAGGIALRSTGPSWALF-VGTAVLGGGIAI----GNTLLPSLIKRDFPSQITKLTAIYSVtMGVVSAVGSAMVVPLL 158
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLlLALFLLGLGLGLldvaANPYVAALGPETAASRLNLLHAFFSL-GALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 159 YAFNWQVSLGAFLVLPIVSALIWLPQLRRHSRPSADTAAPPHGGP--IWRSPLAWQVTLFFGINSFVYYAVAAWLPSILV 236
Cdd:COG0738 159 LSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLksLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 237 D-LGYTQGEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKL-FPLIAIVWVSLFGFGIGGAF- 313
Cdd:COG0738 239 DvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLApGPWLALIGLALVGLGLSLMFp 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 806506617 314 -IVALAFIGLRTSSAQQTASLSGMtqsiGYLMSATGPVLVGLLHDATNdWSTVLMVCMAMCVVLAGVGLGAGRA 386
Cdd:COG0738 319 tIFSLALDGLGKRTAAAVSAVLIM----GIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-377 |
4.53e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.17 E-value: 4.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGTA 107
Cdd:cd06174 13 GLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSfWLLLLGRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNW---QVSLGAFLVLPIVSALIWLP 183
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 184 QLRRHSRPSADTAAPPHG------GPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLAS 256
Cdd:cd06174 173 VPDPPESARAKNEEASSKsvlkllKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 257 ALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIG-GAFIVALAFIGLRTSSAQQTASLSG 335
Cdd:cd06174 253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFPPEIRGTAFG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 806506617 336 MTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLA 377
Cdd:cd06174 333 LLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-349 |
9.93e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 74.76 E-value: 9.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 28 FTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRS-TGPSWALFVGT 106
Cdd:pfam07690 13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLfASSLWLLLVLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 107 AVLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQL 185
Cdd:pfam07690 93 VLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 186 RRHSRPSADTAAPPHGGP------IWRSPLAWQVTLFFgINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALP 259
Cdd:pfam07690 173 PPPESKRPKPAEEARLSLivawkaLLRDPVLWLLLALL-LFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 260 GLLIVPIVQR--ARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAF-IGLRTSSAQQTASLSGM 336
Cdd:pfam07690 252 RLLLGRLSDRlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNaLVSDLAPKEERGTASGL 331
|
330
....*....|...
gi 806506617 337 TQSIGYLMSATGP 349
Cdd:pfam07690 332 YNTAGSLGGALGP 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-381 |
1.21e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 68.74 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 31 ISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAVLG 110
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 111 G-GIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQLRRHS 189
Cdd:cd17478 95 GiGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 190 RPSADTAAPPHGGPIWRS--PLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLIVPIV 267
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGvwRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 268 QRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFiglrtssAQQ-----TASLSGMTQSIGY 342
Cdd:cd17478 255 DRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVL-------AQEllpgnVGLASGLMMGLSF 327
|
330 340 350
....*....|....*....|....*....|....*....
gi 806506617 343 LMSATGPVLVGLLHDATNdwstvLMVCMAMCVVLAGVGL 381
Cdd:cd17478 328 GLGGIGAPVLGALADAFG-----LESVLLILALLPLLGA 361
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
30-381 |
1.53e-11 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 65.40 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 30 AISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRS-TGPSWALFVGTAV 108
Cdd:cd06180 17 AYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMAlTSGFAALLALRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 109 LGGGIAIGNTLLPSLIKRDFPSQ-ITKLTAIYSVTMGVVSAVGSAMVVPLLYAFN-----WQVSLGAFLVLPIVSALIWL 182
Cdd:cd06180 97 AGAASAFVFVFGSNLVLHHATAAgRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLswragWLALALLSAVLLLLSFLLLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 183 PQLRRHSRPSADTAAPPHGGPIWRsplawqVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLL 262
Cdd:cd06180 177 RGPSAPTEASAAESAPGLNRPLWR------LALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 263 IVPIVQRARDQRGLAVGLALAGLVSLIGLkLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQTASLSGMTQSIGY 342
Cdd:cd06180 251 WGALSDRWGTRRALAANLLVQAVGVLLPL-LSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMTASFG 329
|
330 340 350
....*....|....*....|....*....|....*....
gi 806506617 343 LMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd06180 330 VGQILGPLLAGWLADATGGFAPALILAAAALVVAALLAL 368
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-375 |
1.71e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.26 E-value: 1.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 14 IAGILVFATNLrgpftAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIAL 93
Cdd:cd17324 6 LAAFAIGTTEY-----VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 94 RSTGPS-WALFVGTAVLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFL 171
Cdd:cd17324 81 AALAPSfALLLLARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 172 VLPIVSALI---WLPQLRRHSRPSADTAAPPHGgpIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSL 248
Cdd:cd17324 161 VLALLAALLlwrLLPSLPPKKPGSLGLLSSLLL--LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 249 hgtMQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVS-----LFGFGIGGAFIVALAFIGLR 323
Cdd:cd17324 239 ---LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLlvglvLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 806506617 324 TSSAQQTAslSGMTQSIGYLMSATGPVLVGLLHDATnDWSTVLMVCMAMCVV 375
Cdd:cd17324 316 APEARGLA--SSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLL 364
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-381 |
3.08e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.13 E-value: 3.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGT-A 107
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLrF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLpqlr 186
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPaRERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 187 rhsrpsadtaapphggpiWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPGLLIVP 265
Cdd:cd17319 176 ------------------FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 266 IVQR--ARDQRGLAVGLALAGLVSLIGLKLF--PLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQqTASLSGMTQSIG 341
Cdd:cd17319 238 LSDRllRGARRLVIIIGLLLAAVGLLLAYLTtsPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEA-AATAGGLINSGG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 806506617 342 YLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd17319 317 NLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-355 |
4.38e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 63.75 E-value: 4.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGTA 107
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNlPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGGGIAIgNTLLPSLIKRDFPSQITKLT-AIYSVTMGVVSAVGSAMVVPLLYAFNWQ----VSLGAFLVLPIVSALIWL 182
Cdd:cd17504 93 LQGIGGAV-FPLAFALVREEFPPERVPVAqGILSATFGIGAGIGLPLGGWIVQHLGWRwifwTAAPVAVLLAALVPLIDL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 183 PQLRRHSrpsadtaapphggpIWrspLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQG--EAGSLHGTMQLASALPG 260
Cdd:cd17504 172 RLLRRRN--------------VL---LANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGitEAGLLLLPGALVMLIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 261 LLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFI-VALAFIGLRTSSAQQTASLSGMTQS 339
Cdd:cd17504 235 PLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAfASLPNIVVESVPPDRTGIATGMNTV 314
|
330
....*....|....*.
gi 806506617 340 IGYLMSATGPVLVGLL 355
Cdd:cd17504 315 LRTIGSAIGPAIAGAI 330
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
31-379 |
8.77e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 8.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 31 ISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGTAVL 109
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSfALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 110 GGGIAIGNTLLPSLIKRDFPSQI-TKLTAIYSVTMGVVSAVGSAmVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQLRRH 188
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGErAKAMGLYEAALGLGIAVGPL-LGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 189 SRPSADTAAPPHGGPIWRSPLAWQVTLFFG--INSFVYYAVAAWLPSILVDL-GYTQGEAGSLHGTMQLASALPGLLIVP 265
Cdd:cd17474 177 KEKAKSSSATKLRDLKKALRGRGLLTFLVSafLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 266 IVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIG-GAFIVALAFIGLRTSSAQQTASLSGMTQSIGYLM 344
Cdd:cd17474 257 LLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGlGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
330 340 350
....*....|....*....|....*....|....*
gi 806506617 345 SATGPVLVGLLHDATNdWSTVLMVCMAMCVVLAGV 379
Cdd:cd17474 337 QAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-375 |
8.91e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.03 E-value: 8.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 28 FTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGG-IALRSTGPSWALFVGT 106
Cdd:cd17475 12 AQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAaLLMALVGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 107 AVLGGGIAIGNTLLPSLIKRDFPSQITKL-TAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQL 185
Cdd:cd17475 92 FLVGAGYGSVQPGGGRAIMRWFPPRERGLaMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 186 RRHSRPSADTAAPPH----GGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPG 260
Cdd:cd17475 172 REPPAASAATESASTllrsLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 261 LLIVPIVQRARDQR--------GLAVGLALAGLVSLIGLKLFPLIAIVWV--SLFGFGIGGAFIVALAfiglRTSSAQQT 330
Cdd:cd17475 252 IGLGRVSDRVFGGRrrpvlvitAAIAAAALLVLSLLSPGTPLWLLVLLLIllGLFAIGWNGLYLTLVA----ESAGPEQA 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 806506617 331 ASLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVV 375
Cdd:cd17475 328 GTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVL 372
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
31-379 |
1.50e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.19 E-value: 1.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 31 ISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGTAVL 109
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSpWVWFLLRFVM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 110 GGGIAIGNTLLPSLI-KRDFPSQITKLTAIYSVTMGVVSAVGsamvvPLLYAFNWQVSLGAFLVLPIVSALIWLPQ-LRR 187
Cdd:cd17477 95 GIGLAGLFVVSESWLnALATNENRGRVLGLYSTVLGLGFALG-----PLLLALVGTAGALPFLIAAVLLLLALVPLlLTR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 188 HSRPSADTAAPPHGGPIWR-SPLAWQVTLFFGINSFVYYAVaawLPSILVDLGYTQGEAGSLHGTMQLASALPGLLIVPI 266
Cdd:cd17477 170 RAAPEIEEAESISLRRLLRiAPLALLGAFVAGFLEGAFYSL---LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 267 VQRArDQRGLAVGLALAGLVSLIGLKLF---PLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQ--QTASLSGMTQSIG 341
Cdd:cd17477 247 ADRF-DRRRVLLGCALLGALAALLLPLVpglPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDElvAANAALLLLYGLG 325
|
330 340 350
....*....|....*....|....*....|....*...
gi 806506617 342 ylmSATGPVLVGLLHDATNDwSTVLMVCMAMCVVLAGV 379
Cdd:cd17477 326 ---SVIGPLLAGALMDAFGP-HGLFLFLAAVALLFLLF 359
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-379 |
1.49e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 28 FTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTA 107
Cdd:cd17325 12 YGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGG-GIAIGNTLLPSLIKRDFPS-QITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALI--WLP 183
Cdd:cd17325 92 FLQGlASAAVWPAAMALIADIAPPeERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLalLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 184 QLRRHSRPSADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLI 263
Cdd:cd17325 172 PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 264 VPIVQRARDQRG----LAVGLALAGlVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVA--LAFIGLRTSSAQQTASLsGMT 337
Cdd:cd17325 252 QPPAGKLSDRIGrkplILIGLLLSA-VALLLLPLATSFWLLLLLLALLGLGLGLVFPatLALLADIVPPEGRGTAM-GLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 806506617 338 QSIGYLMSATGPVLVGLLHDaTNDWSTVLMVCMAMCVVLAGV 379
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-378 |
2.35e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 58.49 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 30 AISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAVL 109
Cdd:cd17333 14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 110 ---GGGI--AIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMV-VPLLYAFNWQVSLGAFLVLPIVSALIWLP 183
Cdd:cd17333 94 aglGAGIldTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 184 QLRRHS-RPSADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDL-GYTQGEAGSLHGTMQLASALPGL 261
Cdd:cd17333 174 ELPSARnPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKkHVSDGLAGYLLSGFWVGITIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 262 LIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVW-VSLFGFGIGGAFIVALAFIGLRTSsaQQTASLSGMTQSI 340
Cdd:cd17333 254 LGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVaTALLGLFMAALFPTILSLGISNLP--YAKGKGTSVLLAA 331
|
330 340 350
....*....|....*....|....*....|....*...
gi 806506617 341 GYLMSATGPVLVGLLhDATNDWSTVLMVCMAMCVVLAG 378
Cdd:cd17333 332 GSIGGAIIPFIMGFI-AEAVGIQTAMLLITILYAIIFV 368
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-378 |
1.02e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.86 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 31 ISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAVLG 110
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 111 G-GIAIGNTLLPSLIKRDFPS-QITKLTAIYSVTMGVVSA----VGSAMVvplLYAFNWQVslgAFLVLPIVSA----LI 180
Cdd:cd17328 98 GiGEASYSPIAPTIIADLFPKeKRTRALGVFYFAIPLGSGlgyvVGGLVA---QATGGWRW---AFRVTGVLGVllaiLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 181 WLPQLRRHSRPSADTAAPPHGGPIW--------RSPLAWQVTLFFGINSFVYYAVAAWLPS----ILVDLGYTQGEAGSL 248
Cdd:cd17328 172 LLFVREPPRGAAEGGVMAKSTATSFladlkalaKNPSFILSTLGFTAVSFVTGALAFWAPTfflrAFGVGDLSSADVGLI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 249 HGTMQLASALPGLLIVPIVQ---RARDQRG----LAVGLALAGLVSLIGLKLFPL-IAIVWVSLFGFGIGGAFIVALAF- 319
Cdd:cd17328 252 FGAITCIAGVLGVLLGGILAdrlRRKTPRAdplvCAVGLLAAAPFLFLALVLALSnLLLAWVLLFLGEFLLSLNWAPVFa 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 806506617 320 IGLRTSSAQQTASLSGMTQSIGYLM-SATGPVLVGLLHDATND-----------WSTVLMVCMAMCVVLAG 378
Cdd:cd17328 332 ILLYVVIPTRRSTASAIQILLSHLLgDAGSPYLIGLISDLLRQnkdsplaeaasLQYALLLCSFVLVLGGF 402
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-381 |
1.58e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.16 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 34 LLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGTAVLGGG 112
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNyWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 113 I----AIGNTLLPSLIK-RDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVS-----LGAFLVLPIVSALIWL 182
Cdd:cd17371 101 FggewAAGAALMAEYVPaRHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLfllgaLPALLVLFIRRFVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 183 PQLRRHSRPSADTAAPPHGGPIWRSPLA---WQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASAL 258
Cdd:cd17371 181 PQWQAARAARRHFADRPSLRELFSPPLLrttLLASLLATGALGGYYGITTWLPSYLTGeRGLSFEGSAGYLVVTILGGFL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 259 PGLLIVPIVQRARDQRGLAVG--LALAGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGlRTSSAQQTASLSGM 336
Cdd:cd17371 261 GYLAGGFLADRIGRRNNFALFalGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLT-ELFPTAVRATAQGF 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 806506617 337 TQSIGYLMSATGPVLVGLLHDATNdWSTVlMVCMAMCVVLAGVGL 381
Cdd:cd17371 340 CYNVGRIIGALFPFLVGFLATSGS-LGTA-IAVFAAVYYIAGLVL 382
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
29-381 |
2.10e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.58 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGTA 107
Cdd:cd17320 16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSiEQLLIARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGGGIAIGNTLLPSLIKRDFPSQ-ITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQ---VSLGAFLVLPIVSALIWLP 183
Cdd:cd17320 96 LQGLGAAAGSVVARAIVRDLYSGAeLAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRaifVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 184 QLRRHSRPSADTAAPPHG-GPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPGL 261
Cdd:cd17320 176 ETLPEEKRKPLLSSLLRAyKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEqLGLSPAQFGLLFALNAIALILGSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 262 LIVPIVQRARDQRGLAVGLALAGL--------VSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRtssaQQTASL 333
Cdd:cd17320 256 LNGRLVRRFGPRRLLRLGLLLLLAaalvlllaALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP----HVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 806506617 334 SGMTQSIGYLMSATGPVLVGLLHdatNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd17320 332 SALLGFLQFLIGALAGALVGLLP---NGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-182 |
4.63e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.42 E-value: 4.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 5 HRRLHPAWIIAGILVFATNLRGPFTAISPLLdtIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAAL 84
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLY--AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 85 IVMAGGIALRSTGPS-WALFVGTAVLGGGIAIGNTLLPSLI-KRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFN 162
Cdd:cd17325 273 LLSAVALLLLPLATSfWLLLLLLALLGLGLGLVFPATLALLaDIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170 180
....*....|....*....|
gi 806506617 163 WQVSLGAFLVLPIVSALIWL 182
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFL 372
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
38-377 |
5.84e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.10 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 38 IRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSW-----ALFVGTAVLGGG 112
Cdd:cd17393 25 IKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVpalalALFLFGAANGAL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 113 IAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQLRRHSRPS 192
Cdd:cd17393 105 DVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAED 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 193 ADTAAPPhGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPGLLIVPIVQRAR 271
Cdd:cd17393 185 RPDGAGK-PGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDvLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 272 DQRGLAVGLALAGL-VSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGlRTSSAQQTASLSGMTqSIGYLMSATGPV 350
Cdd:cd17393 264 DVAVLRAGALLAALgLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAG-ALPGLAAGIAVARVA-TLGYLGFLVGPP 341
|
330 340
....*....|....*....|....*..
gi 806506617 351 LVGLLHDATNdWSTVLMVCMAMCVVLA 377
Cdd:cd17393 342 LIGFLADATG-LRTAFLVVALLALLVA 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
42-381 |
7.90e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.68 E-value: 7.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 42 FGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGT-----AVLGGGIAIG 116
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLrflqgIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 117 NTLLPSLIKRDFPSQITK-LTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWlpqlrrhsrpsadt 195
Cdd:cd17316 111 STYVAEFAPSKRRGFALGlLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLR-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 196 aapphggpiwrsPLAWQVTLFFGINSFVYYAVAAWLPSILV-DLGYTQGEAGSLHGTMQLASALPGLLIVPIVQRARDQR 274
Cdd:cd17316 177 ------------RRTLLLILLWFFISFGYYGLTTFLPTYLQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 275 GLAVGLALAGLVSLIGLKLFP------LIAIVWVSLFGFGIGGAFIVALAfiglRTSSAQQTASLSGMTQSIGYLMSATG 348
Cdd:cd17316 245 TLVIGLILSGILALPLFYLLSgsptllLLLLFILSFFVGGVWGALYAYLA----ELFPTEVRATGVGLSYNLGRLGGGGA 320
|
330 340 350
....*....|....*....|....*....|...
gi 806506617 349 PVLVGLLHDATNDWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd17316 321 PPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-355 |
2.06e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 30 AISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRS-TGPSWAL----FV 104
Cdd:TIGR00895 35 AMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAlATNVTQLlilrFL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 105 GTAVLGGGIAIGNTLLPslikrDFPSQITKLTAIYSVTMGVV--SAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALI-- 180
Cdd:TIGR00895 115 AGLGLGGLMPNLNALVS-----EYAPKRFRGTAVGLMFCGYPigAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLlm 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 181 -WLPQ---------------------LRRHSRPSADTAAPPHGGPIWRSPLAWQVT-----------LFFGINSFVYYAV 227
Cdd:TIGR00895 190 rFLPEsidflvskrpetvrrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKALFQgktaritvllwLLYFMLLVGVYFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 228 AAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLF-PLIAIVWVSLFG 306
Cdd:TIGR00895 270 TNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFsPTLLLLLGAIAG 349
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 806506617 307 FGIGGAFIVALAFIGLRTSSAQQTASLSGMTqSIGYLMSATGPVLVGLL 355
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPTAIRATGVGWAI-GIGRLGAIIGPILAGYL 397
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-355 |
2.65e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.11 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFV-GTA 107
Cdd:cd17503 13 TIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIiFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQvslGAFLV-LPIVSALIWLPQL 185
Cdd:cd17503 93 LQGFGGGVLIPLAQTILLRIYPpEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWR---WIFYInLPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 186 RRHSrpsadtaapphggpIWRSPLAWQVTLFFGINSFVYYAVAAWLPSIL-VDLGYTQGEAgslhGTMQLASALPGLLIV 264
Cdd:cd17503 170 LDLR--------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLqNVLGYSAFES----GLVLAPGGLASAILS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 265 PIVQRARDQRG----LAVGLALAGLVSLIGLKLFPLIAIVWVSLFGF--GIGGAFI-VALAFIGLRTSSAQQTASLSGMT 337
Cdd:cd17503 232 PLVGRLLDKFGprllLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFirGLGMGLVfMPLNTLALNSLPPEQIGDATALF 311
|
330
....*....|....*...
gi 806506617 338 QSIGYLMSATGPVLVGLL 355
Cdd:cd17503 312 NTIRQLGGSIGTALLATL 329
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
42-379 |
6.26e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 6.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 42 FGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWA-LFVGTAVLGGGIAIGNTLL 120
Cdd:cd17489 26 LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAlLLVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 121 PSLIKRDFPSQ-ITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQLRRHSRPSADTAAPP 199
Cdd:cd17489 106 ATLVADIIPPSrRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 200 HGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQgeAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVG 279
Cdd:cd17489 186 RAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 280 LALAGL-VSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAQQTASLSGMTQSIGYLMSAtGPVLVGLLHDA 358
Cdd:cd17489 264 LLLLALgLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL-GGLLLGLVAEL 342
|
330 340
....*....|....*....|.
gi 806506617 359 TNdwSTVLMVCMAMCVVLAGV 379
Cdd:cd17489 343 FG--YRAMFLLAAVVVLLALV 361
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-379 |
6.38e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAV 108
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 109 -----LGGGIAIGNTLLPSLIKRDFPSQitkLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSAliwlp 183
Cdd:cd17365 96 ltglgLGAAMPNAITLVSEYAPARRRSL---AVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL----- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 184 qlrrhsrpsadtaapphggPIWRSPLAWQVTLFFGInsFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLI 263
Cdd:cd17365 168 -------------------PLLRGTLLLWVTFFMGL--LLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 264 VPIVQRARDQRGLAVGLALAGL-VSLIGLKLFPLIAI-VWVSLFGFGIGGAFIVALAFIGlRTSSAQQTASLSGMTQSIG 341
Cdd:cd17365 227 GWLADRFGPKRVLALFFALGAVsLALLGVSPASLVLLyVLVFLAGACVNGAQVGLYALAA-RFYPTEVRATGVGWALGVG 305
|
330 340 350
....*....|....*....|....*....|....*...
gi 806506617 342 YLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLAGV 379
Cdd:cd17365 306 RLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALA 343
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-180 |
6.51e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.96 E-value: 6.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 41 TFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS--WALFVGTAVLGGGIAIGNT 118
Cdd:cd17504 211 GFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSslWALVVALLLIGIGLGLAFA 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 119 LLPSLI----KRDFPSQITKL------------TAIYSVTMGVVSAVGSAMVVPLLYAFN--WQVSLGAFLVLPIVSALI 180
Cdd:cd17504 291 SLPNIVvesvPPDRTGIATGMntvlrtigsaigPAIAGAILTTYTVSITSGGVPTEGAYVlaFLIGAALALAALLLSLLI 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-381 |
6.51e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 6.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 49 AGFLITLPLLtfcIVSPFAGLLAREYGLERALFAALIVMAGGIAL------RSTGPSWALFVGTAVLGGGIAIG----NT 118
Cdd:cd06173 39 VLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADLLRALLAAVlallalLGSLSLWLLLVLAFLLGIASAFFgparQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 119 LLPSLIKRDfpsQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIwLPQLRRHSRPSADTAAP 198
Cdd:cd06173 116 LLPELVPKE---QLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALL-LLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 199 PHGGP-------IWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPGLLIVPIVQRA 270
Cdd:cd06173 192 LLLRDlreglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 271 RDQRGLAVGLALAGLVSLIglklFPLIAIVWVSLFGFGIGGAF-----IVALAFIGLRTSSAQQtASLSGMTQSIGYLMS 345
Cdd:cd06173 272 RRGRLLLIGALLLGLALLV----LGLSPSLWLLLAALFLLGLAgglfnVPLNTLLQLRVPDELR-GRVFSVYNALNSGAM 346
|
330 340 350
....*....|....*....|....*....|....*.
gi 806506617 346 ATGPVLVGLLHDATNdWSTVLMVCMAMCVVLAGVGL 381
Cdd:cd06173 347 PLGALLAGLLADALG-LSAVFLLAGALLLLAALLLL 381
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
30-319 |
7.63e-06 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 47.78 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 30 AISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERA--LFAALIVMAGGIALRSTG--PSWALFVG 105
Cdd:cd17334 22 TFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGvlIGAALNALGSVLKCIPLGqqPKFALLVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 106 TAVLGGGIAIGNTLLPSLIKRDF--PSQITKLTAIYSVTMGVVSAVGsaMVVPLLYAF-------NWQVSLG---AFLVL 173
Cdd:cd17334 102 GQVLNALAQVLVLSLPPLIAAVWfpPKERTTATAIASLANFLGCAIG--FLLPPVVVPppkgtkkEFGAVFYgefGFACL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 174 PIVSALIWLPQLRRHsRPSADTAAPPHGGPIWRS-----------PLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQ 242
Cdd:cd17334 180 LLALVLALFPPKPKY-PPSAASARQQNSEHVILElqksisellrnEPFVLLAVAFSIMMGVFAGFSSVLAQILLPFGVSQ 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 243 GEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLA-VGLALAGLVS-----LIGLKLFPLIAIVWVSLFGF-GIGGAFIV 315
Cdd:cd17334 259 TSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGlIILALGTVVCtffmlLVDRYGLPYVTLAFYLLCGLlGFFQNSMV 338
|
....
gi 806506617 316 ALAF 319
Cdd:cd17334 339 PIMF 342
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-355 |
9.38e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.17 E-value: 9.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 28 FTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPS-WALFVGT 106
Cdd:cd17321 12 VTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSlAFLIAAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 107 AVLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQvslGAFLV-LPIVSALIWLpq 184
Cdd:cd17321 92 ALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR---WIFLInVPIGLVALLL-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 185 lrrhsrpsadtaapphggpiwrSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPGLLI 263
Cdd:cd17321 167 ----------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 264 VPIVQRARDQRGLAVGLAL--AGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAF-IGLRTSSAQQTASLSGMTQSI 340
Cdd:cd17321 225 GRLADRFGPRLVLVAGLLLtaVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTnAALSSVPKEKAGAASGILNTA 304
|
330
....*....|....*
gi 806506617 341 GYLMSATGPVLVGLL 355
Cdd:cd17321 305 RQLGGALGVALLGAL 319
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-385 |
9.90e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 9.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 34 LLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAVLGGGI 113
Cdd:cd17352 25 LFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 114 AIGNTLLPSL--IKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQvslGAFLVLPIVSALIW----LPQLRR 187
Cdd:cd17352 105 GLGLIYSPAIviVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR---GALLILGGLCLNLCvcglLLRLLK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 188 HsrpsadtaapphggPIWRSPLAWQVTLFFGINSFVYYavaawLPSILVDLGYTQGEAGSLhGTMQLASALPGLLIVPIV 267
Cdd:cd17352 182 D--------------PTFVLLALGVSFAMLGFFVPFVY-----LPSYAKSLGIDESDAAFL-LSIIGISDIVGRILLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 268 QRARDQRGLAVGLALAGLVSLIGLkLFPLIA-----IVWVSLFGFGIGG--AFIVALAFIGLRTSSAQQTASLSGMTQSI 340
Cdd:cd17352 242 ADKPRIGRLYLYIFTLLILGLSLL-AFPLATtyvglIVFSVLFGFCSGSysSLTPVILADLVGLEKLSNAYGLVLLFQGL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 806506617 341 GYLmsaTGPVLVGLLHDATNDWSTVLMVCmAMCVVLAGVGLGAGR 385
Cdd:cd17352 321 AAL---VGPPIAGLLRDYTGDYDAAFYFC-GACLLLSGVLLFLLP 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-190 |
9.97e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 9.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 38 IRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLER---ALFAALIVMAGGIALRSTGPSWALFVGTAVLGGGIA 114
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 806506617 115 IGNTLLPSLIKRDFPSQIT-KLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQLRRHSR 190
Cdd:COG2271 287 GAFGLLWALAAELFPKKARgTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-375 |
1.72e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 30 AISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAVL 109
Cdd:cd17312 21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 110 GG-----GIAIGNTLLPSLIKrdfPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVS-LGAFLVLPIVSALIWLp 183
Cdd:cd17312 101 NGlfqsmGWPPCVKLLGNWFS---KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAfLVPGIVGLVVAIILFF- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 184 qlRRHSRPsadtaapphggpiwrsPLAWQVTLFFGINSFVYYAVAAWLPSILVDL-GYTQGEAGSLHGTMQLASALPGLL 262
Cdd:cd17312 177 --FLRDSP----------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVkGYSLIDAGWFSSLYEVGGIAGTIL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 263 IVPIVQRARDQ-RGLAVGLALAGLVSLIGLKLFPLIAIVWVSLF----GFGIGG--AFIVALAFIGLRTSSAQQTAslSG 335
Cdd:cd17312 239 AGLLSDKLFGGrRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLlfliGFFVGGpiNLIGGAAAQDIGRKEAAGTA--TG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 806506617 336 MTQSIGYLMSATGPVLVGLLHDATnDWSTVLMVCMAMCVV 375
Cdd:cd17312 317 FVGLFGYLGASLAGLPLGYIIDHY-GWSTVFYFLISAALL 355
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
28-291 |
6.80e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.42 E-value: 6.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 28 FTAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTA 107
Cdd:COG0477 30 FTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGG-GIAIGNTLLPSLIKRDFPSQI-TKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWLPQL 185
Cdd:COG0477 110 ALQGiGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 186 RRHSRPSADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLIVP 265
Cdd:COG0477 190 ESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLL 269
|
250 260
....*....|....*....|....*.
gi 806506617 266 IVQRARDQRGLAVGLALAGLVSLIGL 291
Cdd:COG0477 270 LLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
29-377 |
7.30e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 7.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVM---AGGIALRSTGPSWALFVG 105
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLlipLLALALAVSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 106 --TAVLGGGIAIGNTLLPSLikrdFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYA--------FNWQVSLGAFLVLPI 175
Cdd:cd17341 96 flLGFAGANFASGQPWASFW----FPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGaivfdggfVGWRNAFFVPGILLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 176 VSALIWLPQLRRHsrPSADTAAPPHGGPIW---RSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGT 251
Cdd:cd17341 172 IAAVLVLLFGDDL--PTGKASALEFLKVQLavlKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTrFGLPLVTAGILAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 252 MQLASALP----GLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSA 327
Cdd:cd17341 250 FPLAGALArpagGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFR 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 806506617 328 QQTASLSGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCMAMCVVLA 377
Cdd:cd17341 330 RELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACT 379
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
4-184 |
7.85e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 7.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 4 SHRRLHPAWIIAGILVFATnlrGPFTAISPLLdtIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAA 83
Cdd:cd06173 206 RSPLLRLLLLALALFALLG---GALTVLLPLL--AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 84 LIVMAGGIALRSTGPS-WALFVGTAVLGGGIAIGNTLLPSLIKRDFPSQIT-KLTAIYSVTMGVVSAVGSAMVVPLLYAF 161
Cdd:cd06173 281 ALLLGLALLVLGLSPSlWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
170 180
....*....|....*....|...
gi 806506617 162 NWQVSLGAFLVLPIVSALIWLPQ 184
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
40-320 |
8.81e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 8.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 40 DTFGMGSSEAGFLITLPLLTFCIVSPFAGLLA----REYGLER--ALFAALIVMAGGIAL------RSTGPSWALFVGTA 107
Cdd:COG2211 39 DVLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRpwILIGAIPLALSFVLLftapdlSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 108 VLGGGIAIGNT----LLPSLIKRdfPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLG---AFLVLPIVSAL- 179
Cdd:COG2211 119 LLGLAYTLVNIpysaLGAELTPD--YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGyrlTALIFAVLGLLa 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 180 IWLPQLRRHSRPSADTAAPPHG---GPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVdlgYTQGEAGSLHGTMQLAS 256
Cdd:COG2211 197 FLLTFFGTKERPVPEEEKVSLKeslKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK---YVLGLSAALVGLLLALY 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 806506617 257 ALPGLLIVPIVQRARDQRGLAVGLALAGLVSLIGLKLFPLI-------AIVWVSLFGFGIGGAFIVALAFI 320
Cdd:COG2211 274 FLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpgnlwlLLVLAALAGIGLGAILVLPWAML 344
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
29-384 |
9.87e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.86 E-value: 9.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 29 TAISPLLDTIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSW--ALFVGT 106
Cdd:cd17314 20 LSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSfpLSYACF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 107 AVLGGGIAIGNTLLPSLIKRDFPSQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQvslGAFLVLPIVSALIWLPQLR 186
Cdd:cd17314 100 VFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLA---LVYTILGILAAIVLSVVSL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 187 RHSRPSADTAAPPHG-GPIWRSPLAWQVTLFFGINSFVYYAVA-AWLPSILVDLGYT---QGEAGSLHGTMQLASALPGL 261
Cdd:cd17314 177 LGFKEPPDNQARLHVqKKKTQTMGEIFRDKVFWILFIAIFLVLiGGFLFIANMASLVrslQLDAPSFVTKLMSIYGLFNA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 262 LIVPIVQRARDQRG-----LAVGLALAGLV---SLIGLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGLRTSSAqQTASL 333
Cdd:cd17314 257 FGRLLWGIVADFFGgrlstLSILLTILGLGlcaFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTE-SFATL 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 806506617 334 SGMTQSIGYLMSATGPVLVGLLHDATNDWSTVLMVCmAMCVVLAGVGLGAG 384
Cdd:cd17314 336 YGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIY-AVIVFLASAILLAV 385
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
42-164 |
1.10e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 42 FGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRS----TGPSWALFVGTAVLGGGIAIGN 117
Cdd:cd17503 209 LGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAfltpDTSLWLIILPLFIRGLGMGLVF 288
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 806506617 118 TLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAFNWQ 164
Cdd:cd17503 289 MPLNTLALNSLPpEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQF 336
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
42-182 |
2.66e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 42 FGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGG-IALRSTGPSWALFVGTAVLGGGIAIGNTLL 120
Cdd:cd17370 229 LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAyLGFALGSSLWLLLLGFILWGLYMGAQESIE 308
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806506617 121 PSLIKRDFPSQITKLT-AIYSVTMGVVSAVGSAMVVPLLYAFNWQVSLGAFLVLPIVSALIWL 182
Cdd:cd17370 309 RAAVADLVPAELRGTAyGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
38-124 |
2.87e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.50 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 38 IRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGG---IALRSTGPSWALFVGTAVLGGGIA 114
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGlllLFFLGPGNLWLLLVLAALAGIGLG 334
|
90
....*....|
gi 806506617 115 IGNTLLPSLI 124
Cdd:COG2211 335 AILVLPWAML 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-381 |
3.02e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 40 DTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGGIALRSTGPSWALFVGTAVLgggIAIGNTL 119
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL---TGFGGGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 120 LPSLIKRDF-----PSQITKLTAIYSVTMGVVSAVGSAMVVPLL-YAFNWQVSLGA-FLVLPIVSALIWLPQLRRHSRPS 192
Cdd:cd17329 105 FEPASEAMIadvttPENRTRAFSLLYWAINLGVAIGPLLGGLLLlYSFRLLFLAAAvLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 193 ADTAAPPHGGPIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVD-LGYTQGEAGSLHGTMQLASALPGLLIVPIVQRAR 271
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEiLGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 272 DQRGLAVGLALAGL---VSLIGLKLFPLIAIVWV----SLFGFGIGGAFIVALAFIGLRtssaqqtASLSGMTQSIGYLM 344
Cdd:cd17329 265 LRKILMIGILLFAIgfaVLAFANTLAVLILAMIVltlgEMLVFPAVQTLVAALAPPDKR-------GSYMGFYALAWGLG 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 806506617 345 SATGPVLVGLLHDATNDWSTVLMvcMAMCVVLAGVGL 381
Cdd:cd17329 338 RAIGPLVGGLLLDLLGPGLPWLI--LAALGLIAAALL 372
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-161 |
3.05e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 11 AWIIAGILVFATnlRGPFTAISPLLdtIRDTFGMGSSEAGFLITLPLLTFCIVSPFAGLLAREYGLERALFAALIVMAGG 90
Cdd:cd17321 172 GAVLAAFLLGAA--LGGLLFLLPLY--LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 806506617 91 IALRST----GPSWALFVGTAVLGGGIAIGNTLLPSLIKRDFP-SQITKLTAIYSVTMGVVSAVGSAMVVPLLYAF 161
Cdd:cd17321 248 LLLLALlgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPkEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
203-381 |
3.58e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 203 PIWRSPLAWQVTLFFGINSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLIVPIVQRARDQRGLAVGLAL 282
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 283 AGLVSLI-GLKLFPLIAIVWVSLFGFGIGGAFIVALAFIGlRTSSAQQTASLSGMTQSIGYLMSATGPVLVGLLHDATnD 361
Cdd:COG2814 85 FALGSLLcALAPSLWLLLAARFLQGLGAGALFPAALALIA-DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-G 162
|
170 180
....*....|....*....|
gi 806506617 362 WSTVLMVCMAMCVVLAGVGL 381
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLL 182
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
147-329 |
4.20e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 39.13 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 147 SAVGSAMVVPLLYAFNWQvslGAFLVLPIVSALIWLPQLRRHSRPSADTAAPPHGGPI--------WRSPLAWQVTLFFG 218
Cdd:cd17485 141 SLLGGGGLLWLYDLIGWQ---SLLLSLAALYLLLLLPVLFLRELELPQQPPASERGAAlkaslrafLRRPGTRWLLLFLL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806506617 219 INSFVYYAVAAWLPSILVDLGYTQGEAGSLHGTMQLASALPGLLI--VPIVQRARDQRGLAVGLALAGLVSLIGLKLFPL 296
Cdd:cd17485 218 LYKLGEQGALAMLPPFLVDRGFSLSQIGLLSGVGGSLVSIAGSLLggYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGG 297
|
170 180 190
....*....|....*....|....*....|....*....
gi 806506617 297 IAIVW------VSLFGFGIGGAFIVALAFIGLRTSSAQQ 329
Cdd:cd17485 298 SGLNWvlllasLALLHLVGGMITTALFTLMMDCSQQAQA 336
|
|
| |
