|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
157-485 |
1.76e-83 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 262.95 E-value: 1.76e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 157 ITTVSSLNTAEFQGKLYMLLKTSFLENMLLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKLNTPIQ 236
Cdd:COG5002 56 LLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 237 LGIKRNDELGSLAKTIEDLSSELTYMKKERNEFLASVAHELLTPLTYMKGYAKVAKRD-TLTKEEREEYLQIIEDETDSV 315
Cdd:COG5002 136 LRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERREYLEIILEEAERL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 316 TDLVQDLFMLVQLEQHQFVIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDD-LEVCIDERRMEQVMLNLLHNAYQ 394
Cdd:COG5002 216 SRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQVLTNLLDNAIK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 395 HSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKL 474
Cdd:COG5002 296 YTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEP 375
|
330
....*....|.
gi 806951658 475 GVGTTFIIELP 485
Cdd:COG5002 376 GKGTTFTITLP 386
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
264-485 |
5.21e-75 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 235.96 E-value: 5.21e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 264 KERNEFLASVAHELLTPLTYMKGYAKVAKRD-TLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLL 342
Cdd:COG2205 14 RLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 343 RPFLERMVEKTKTTLTNKQMQLHVYC-KDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEG 421
Cdd:COG2205 94 AELLEEAVEELRPLAEEKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 806951658 422 EGIPEEDIPHIFDRFYRVDksRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:COG2205 174 PGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
264-487 |
1.88e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 222.09 E-value: 1.88e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 264 KERNEFLASVAHELLTPLTYMKGYAKVAKRDTltKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLR 343
Cdd:COG0642 108 EAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLA 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 344 PFLERMVEKTKTTLTNKQMQLHVYCKDDLE-VCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGE 422
Cdd:COG0642 186 ELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGP 265
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 806951658 423 GIPEEDIPHIFDRFYRVDKSRTraTGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:COG0642 266 GIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
235-485 |
1.62e-45 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 162.66 E-value: 1.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 235 IQLGIKRNDELGSLAKTIEDLSSELTYMKKERNEFL------------ASVAHELLTPLTYMKGYAKVAKR---DTLTKE 299
Cdd:COG4191 99 AALDAEENAELEELERDITELERAEEELRELQEQLVqseklaalgelaAGIAHEINNPLAAILGNAELLRRrleDEPDPE 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 300 EREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQfvikKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDDL-EVCIDE 378
Cdd:COG4191 179 ELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALELLRPRLKARGIEVELDLPPDLpPVLGDP 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 379 RRMEQVMLNLLHNAYqHSLENT---TITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRvdksrTRATG-GKGIGL 454
Cdd:COG4191 255 GQLEQVLLNLLINAI-DAMEEGeggRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFT-----TKPVGkGTGLGL 328
|
250 260 270
....*....|....*....|....*....|.
gi 806951658 455 AVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:COG4191 329 SISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
251-485 |
5.16e-45 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 162.82 E-value: 5.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 251 TIEDLSSELtymKKERN----EFLASVAHELLTPLTYMKGYA-----KVAKRDTLTKEEREEYLQIIEDETDSVTDLVQD 321
Cdd:COG5000 185 VFDDITELL---RAERLaawgELARRIAHEIKNPLTPIQLSAerlrrKLADKLEEDREDLERALDTIIRQVDRLKRIVDE 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 322 LFMLVQLEQhqfvIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDDL-EVCIDERRMEQVMLNLLHNAYQHSLENT 400
Cdd:COG5000 262 FLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGG 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 401 TITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTF 480
Cdd:COG5000 338 EIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTF 411
|
....*
gi 806951658 481 IIELP 485
Cdd:COG5000 412 TIRLP 416
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
268-487 |
6.71e-43 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 155.39 E-value: 6.71e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 268 EFLASVAHELLTPLTYMKGYAKVAKRDtLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQhqfvIKKQKVLLRPFLE 347
Cdd:COG3852 137 ELAAGLAHEIRNPLTGIRGAAQLLERE-LPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLE 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 RMVEKTKTTLtNKQMQLHVYCKDDL-EVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFT----------IS 416
Cdd:COG3852 212 RVLELLRAEA-PKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyvrIE 290
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 806951658 417 VQDEGEGIPEEDIPHIFDRFYRvdksrTRAtGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:COG3852 291 VIDNGPGIPEEILDRIFEPFFT-----TKE-KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
266-485 |
1.87e-42 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 155.94 E-value: 1.87e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 266 RNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLrPF 345
Cdd:PRK11006 204 RRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDV-PM 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 346 LERMVEKTKTTLTNKQMQLHVYCKDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIP 425
Cdd:PRK11006 283 MLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIA 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 426 EEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK11006 363 PEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
176-485 |
2.54e-39 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 147.92 E-value: 2.54e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 176 LKTSFLENMLLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMS--KLNTPIQLGIKrNDELGSLA---- 249
Cdd:TIGR01386 150 LDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISpeSLDQRLDPSRA-PAELRELAqsfn 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 250 ---KTIEDlsselTYMKKERneFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLV 326
Cdd:TIGR01386 229 amlGRLED-----AFQRLSQ--FSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLA 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 327 QLEQHQFVIKKQKVLL-------RPFLERMVEKTKTTLTnkqmqlhvyCKDDLEVCIDERRMEQVMLNLLHNAYQHSLEN 399
Cdd:TIGR01386 302 RADNGQLALERVRLDLaaelakvAEYFEPLAEERGVRIR---------VEGEGLVRGDPQMFRRAISNLLSNALRHTPDG 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 400 TTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSkLGVGTT 479
Cdd:TIGR01386 373 GTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAES-PDGKTR 451
|
....*.
gi 806951658 480 FIIELP 485
Cdd:TIGR01386 452 FILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
239-485 |
5.48e-39 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 148.01 E-value: 5.48e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 239 IKRNDELGSLAKTIEDLSSELTYMKKERNEFLASVAHELLTPLTYMKGYAKVAKRDTLTK--EEREEYLQIIEDETDSVT 316
Cdd:COG4251 255 LELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKldEEGREYLERIRDAAERMQ 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 317 DLVQDLFMLVQLEQHQfvIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVyckDDL-EVCIDERRMEQVMLNLLHNA--Y 393
Cdd:COG4251 335 ALIDDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIEV---GPLpTVRGDPTLLRQVFQNLISNAikY 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 394 QHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRatGGKGIGLAVAKEIVELHNGAILVTSK 473
Cdd:COG4251 410 SRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESE 487
|
250
....*....|..
gi 806951658 474 LGVGTTFIIELP 485
Cdd:COG4251 488 PGEGATFYFTLP 499
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
376-487 |
6.00e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 137.01 E-value: 6.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 376 IDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKsRTRATGGKGIGLA 455
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 806951658 456 VAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
381-484 |
7.06e-38 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 133.88 E-value: 7.06e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRatGGKGIGLAVAKEI 460
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 806951658 461 VELHNGAILVTSKLGVGTTFIIEL 484
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
239-485 |
1.13e-37 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 143.96 E-value: 1.13e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 239 IKRNDELGSLAKTIEDLSSELTYMKKERN--------EFLASVAHELLTPLTYMKGYAKVAKRDTltKEEREEYLQIIED 310
Cdd:COG5809 235 IKKNGEVDGIVIIFRDITERKKLEELLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTI--DEEQKTYLDIMLS 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 311 ETDSVTDLVQDLFMLVQLEqhqfVIKKQKVLLRPFLERMVE--KTKTTLTNKQMQLHVYCKDDLEVCiDERRMEQVMLNL 388
Cdd:COG5809 313 ELDRIESIISEFLVLAKPQ----AIKYEPKDLNTLIEEVIPllQPQALLKNVQIELELEDDIPDILG-DENQLKQVFINL 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 389 LHNAYQHSLENTTITIRVLAETNSF-TISVQDEGEGIPEEDIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGA 467
Cdd:COG5809 388 LKNAIEAMPEGGNITIETKAEDDDKvVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGK 461
|
250
....*....|....*...
gi 806951658 468 ILVTSKLGVGTTFIIELP 485
Cdd:COG5809 462 ITVESEVGKGTTFSITLP 479
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
194-487 |
1.53e-36 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 140.54 E-value: 1.53e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 194 IISVLTVILTTISVFVFSRVITEPLikmKRATEKMSKL---NTPIQLGIKRNDELGSLAKTIEDLSSELTYMKKERNEFL 270
Cdd:PRK10549 168 LIVALSTLLAALATFLLARGLLAPV---KRLVEGTHKLaagDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFM 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 271 ASVAHELLTPLTYMKGYAKvAKRDTLTKEEREEyLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPFLERMV 350
Cdd:PRK10549 245 ADISHELRTPLAVLRGELE-AIQDGVRKFTPES-VASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAG 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 351 EKTKTTLTNKQMQLHVYCKDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIP 430
Cdd:PRK10549 323 GAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQ 402
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 431 HIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVT-SKLGvGTTFIIELPFE 487
Cdd:PRK10549 403 KLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELPLE 459
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
268-485 |
1.93e-36 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 142.03 E-value: 1.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 268 EFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREeYLQIIEDETDSVTDLVQDLFMLVQLEQHQFvikkQKVLLRPFLE 347
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQE-YLSVVLREVDRLNKVIDQLLEFSRPRESQW----QPVSLNALVE 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 RMVEKTKTTLTNKQMQLHVYCKDDLE-VCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNS-FTISVQDEGEGIP 425
Cdd:PRK11360 467 EVLQLFQTAGVQARVDFETELDNELPpIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGqVAVSIEDNGCGID 546
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 426 EEDIPHIFDRFYRvdksrTRATGgKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK11360 547 PELLKKIFDPFFT-----TKAKG-TGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
268-486 |
8.52e-34 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 130.68 E-value: 8.52e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 268 EFLASVAHELLTPLTYMKGYAKVAKRDTlTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQhqfvIKKQKVLLRPFLE 347
Cdd:COG5807 149 ELAAGIAHEIRNPLTSIKGFLQLLQESR-EDSEREEYFNIIISEIDRINTIITELLVLSKPKK----FNFKKLNLNDVLE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 RMVEKTKTTLTNKQMQLHVYCKDDLEVC-IDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPE 426
Cdd:COG5807 224 DVIALLSTEAILKNISIKYDLADDEPVInGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPE 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 427 EDIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPF 486
Cdd:COG5807 304 EVLEKIGEPFF------TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
190-470 |
8.99e-34 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 132.66 E-value: 8.99e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 190 NQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKlNTPIQLGIKRNDELGSLAKTIEDLSSELT---YMkkER 266
Cdd:PRK11100 182 RRILWAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTE-GKPVPLPKLGSSELRELAQALESMRVKLEgkaYV--EQ 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 267 neFLASVAHELLTPLTYMKGYAKVAkRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPFL 346
Cdd:PRK11100 259 --YVQTLTHELKSPLAAIRGAAELL-QEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALL 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 347 ERMVEKTKTTLTNKQMQLHVYCkDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPE 426
Cdd:PRK11100 336 EELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPD 414
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 806951658 427 EDIPHIFDRFYrvdkSRTRATGGK---GIGLAVAKEIVELHNGAILV 470
Cdd:PRK11100 415 YALPRIFERFY----SLPRPANGRkstGLGLAFVREVARLHGGEVTL 457
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
271-485 |
1.12e-33 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 132.93 E-value: 1.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 271 ASVAHELLTPLTYMKGYAKVAKrdtLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLR---PFLE 347
Cdd:COG5805 292 AGIAHEIRNPLTSIKGFLQLLQ---PGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQdvvTLLE 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 rmvekTKTTLTNKQMQLHvYCKDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEE 427
Cdd:COG5805 369 -----TEAILHNIQIRLE-LLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEE 442
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 428 DIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:COG5805 443 RLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
377-487 |
5.14e-33 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 120.94 E-value: 5.14e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNsFTISVQDEGEGIPEEDIPHIFDRFYRVDKsrtRATGGKGIGLAV 456
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|.
gi 806951658 457 AKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
263-485 |
3.18e-32 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 128.33 E-value: 3.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 263 KKERNEFLASVAHELLTPLTYMKGYAKVAKrDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEqhqfVIKKQKVLL 342
Cdd:COG5808 238 LELIGTFAASTAHEIRNPLTSIKGFIQLLQ-EKYPELEDQKYFDIIQEEIQRINQIVSEFLVLGKPT----AKKLELDDL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 343 RPFLERMVEKTKTTLTNKQMQLHVYCKDD-LEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEG 421
Cdd:COG5808 313 NELIEEILSIIDSEANLKNIRVEKQSLDEpLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDNG 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 806951658 422 EGIPEEDIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:COG5808 393 EGIPEDIIDEIFEPFV------TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
165-485 |
4.25e-32 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 128.35 E-value: 4.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 165 TAEFQGK----LYMLLKTSF----LENMLLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEK-----MSKL 231
Cdd:PRK09835 156 GPLVDGKpiytLLIALSIDFhlhyINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKdldvrLDPQ 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 232 NTPI---QLGIKRNDELGSlaktIEDLsseltyMKKERNeFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQII 308
Cdd:PRK09835 236 TVPIeleQLVLSFNHMIER----IEDV------FTRQSN-FSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSN 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 309 EDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDDLeVCIDERRMEQVMLNL 388
Cdd:PRK09835 305 LEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQ-VAGDPLMLRRAISNL 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 389 LHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAI 468
Cdd:PRK09835 384 LSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTV 463
|
330
....*....|....*..
gi 806951658 469 LVTSKLgVGTTFIIELP 485
Cdd:PRK09835 464 AVTSDA-RGTRFVISLP 479
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
243-485 |
3.46e-29 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 118.13 E-value: 3.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 243 DELGSLAKTIEDLSSELTYmkKERneFLASVAHELLTPLTY--------------MKGYAKVAKRDTLTKEEREEyLQII 308
Cdd:PRK09303 132 DELFVLRQENETLLEQLKF--KDR--VLAMLAHDLRTPLTAaslaletlelgqidEDTELKPALIEQLQDQARRQ-LEEI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 309 EDetdsvtdLVQDLFMLVQLEQHQFVIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDDL-EVCIDERRMEQVMLN 387
Cdd:PRK09303 207 ER-------LITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLN 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 388 LLHNAYQHSLENTTITIRVLAETNSFT-ISVQDEGEGIPEEDIPHIFDRFYRVDksRTRATGGKGIGLAVAKEIVELHNG 466
Cdd:PRK09303 280 LLDNAIKYTPEGGTITLSMLHRTTQKVqVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYG 357
|
250
....*....|....*....
gi 806951658 467 AILVTSKLGVGTTFIIELP 485
Cdd:PRK09303 358 QIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
381-486 |
1.10e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 109.12 E-value: 1.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAyqhsLENTT---ITIRVLAETNSFT-----ISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGI 452
Cdd:cd16922 1 LRQILLNLLGNA----IKFTEegeVTLRVSLEEEEEDgvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGL 76
|
90 100 110
....*....|....*....|....*....|....
gi 806951658 453 GLAVAKEIVELHNGAILVTSKLGVGTTFIIELPF 486
Cdd:cd16922 77 GLAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
262-485 |
6.68e-28 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 115.47 E-value: 6.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 262 MKKERNEFLAS-------VAHELLTPLTYMKgYaKVAKRDTLTKEEReeylQIIEDETDSVTDLVQDLFMLVQLEQHQFV 334
Cdd:PRK10604 201 MADNINALIASkkqlidgIAHELRTPLVRLR-Y-RLEMSDNLSAAES----QALNRDIGQLEALIEELLTYARLDRPQNE 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 335 IKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDDLEVcIDERRMEQVMLNLLHNAYQHSleNTTITIRVLAETNSFT 414
Cdd:PRK10604 275 LHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGA-LDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQAC 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 806951658 415 ISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILV-TSKLGvGTTFIIELP 485
Cdd:PRK10604 352 LIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCdESELG-GARFSFSWP 422
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
271-485 |
4.36e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 113.34 E-value: 4.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 271 ASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVqleqHQFVIKKQKVLLRPFLERMV 350
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELV----KPTHLALQAVDLNDLINHSL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 351 EKTKTTLTNKQMQLHVYCKDDLE-VCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDI 429
Cdd:PRK10364 318 QLVSQDANSREIQLRFTANDTLPeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQL 397
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 806951658 430 PHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK10364 398 EAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-485 |
9.71e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 104.08 E-value: 9.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAV 456
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 806951658 457 AKEIVELHNGAILVT-SKLGvGTTFIIELP 485
Cdd:cd16946 81 CHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
99-487 |
2.93e-26 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 112.81 E-value: 2.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 99 SESIANSDIaIIITDNNGKIISTSEPVTKAMQKQlTCKTEPIPANglvVEKNWKKskfITTVSSLNTaEFQG---KLYML 175
Cdd:PRK15347 211 NHPVLDDDI-NLWLDQNGELLPFSTIPLSSNQLQ-KILNQLENVK---LHDGWQQ---IPDYLVLRT-QLKGpgwQQVTL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 176 LKTSFLENMLLKLMNQFLIISVLTVILTTISVF-VFSRVITEPL-----IKMKRATEKMSKlntpiQLGIKRNDELGSLA 249
Cdd:PRK15347 282 YPRRNLANEALKPALQQLPFALLILVLLTSVLFlLLRRYLAKPLwrfvdIINKTGPAALEP-----RLPENRLDELGSIA 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 250 KTIEDLSS------------------ELTYMKKE-------RNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREeY 304
Cdd:PRK15347 357 KAYNQLLDtlneqydtlenkvaertqALAEAKQRaeqankrKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMD-L 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 305 LQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDD--LEVCIDERRME 382
Cdd:PRK15347 436 ADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHvpLYLHLDSLRLR 515
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 383 QVMLNLLHNAYQHSlENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRtratGGKGIGLAVAKEIVE 462
Cdd:PRK15347 516 QILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHS----QGTGLGLTIASSLAK 590
|
410 420
....*....|....*....|....*
gi 806951658 463 LHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:PRK15347 591 MMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
387-485 |
3.19e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 102.28 E-value: 3.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 387 NLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNG 466
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 806951658 467 AILVTSKLGVGTTFIIELP 485
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
266-487 |
1.43e-25 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 110.51 E-value: 1.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 266 RNEFLASVAHELLTPLTYMKGYAKVAKRDtLTKEEREEYLQI--IEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLR 343
Cdd:PRK10490 664 RNALLAALSHDLRTPLTVLFGQAEILTLD-LASEGSPHARQAseIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLE 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 344 PFLERMVEKTKTTLTNKQMQLHVycKDDLE-VCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGE 422
Cdd:PRK10490 743 EVVGSALQMLEPGLSGHPINLSL--PEPLTlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGP 820
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 806951658 423 GIPEEDIPHIFDRFYRVDKSrtRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:PRK10490 821 GIPPGQEQLIFDKFARGNKE--SAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
377-485 |
5.52e-25 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 99.10 E-value: 5.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRV-LAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLA 455
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 806951658 456 VAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
264-485 |
6.14e-25 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 108.49 E-value: 6.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 264 KERNEFLASVAHELLTPLTYMKGYAKVAkRDT-LTKEEREeYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLL 342
Cdd:PRK11091 281 RDKTTFISTISHELRTPLNGIVGLSRIL-LDTeLTAEQRK-YLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDF 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 343 RPFLERMVEKTKTTLTNKQMQLHVYCKDDL--EVCIDERRMEQVMLNLLHNAYQHSLENTtITIRVLAETN-SFTISVQD 419
Cdd:PRK11091 359 TDFLADLENLSGLQAEQKGLRFDLEPLLPLphKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVRYEEGdMLTFEVED 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 420 EGEGIPEEDIPHIFDRFYRVDKSR--TRATGgKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK11091 438 SGIGIPEDELDKIFAMYYQVKDSHggKPATG-TGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-485 |
1.37e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 95.18 E-value: 1.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 383 QVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdksRTRATG-GKGIGLAVAKEIV 461
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....
gi 806951658 462 ELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILP 104
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
169-485 |
1.62e-23 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 102.25 E-value: 1.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 169 QGKLYMLLKTSF---LENMLLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKlntpiqlgikrndel 245
Cdd:COG5806 126 KGKIVLAILLSFlsaLLLLLLAIIFIADISELLDFILYFIIIQLLAMLIAVYLIENLIENILLRK--------------- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 246 gslaktiedlssELTYMKKER--NEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLF 323
Cdd:COG5806 191 ------------ELQRAEKLEvvSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYL 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 324 MLV--QLEQHQFV-----IKKQKVLLRPFlermvektkTTLTNkqMQLHVYCKDDLEVCIDERRMEQVMLNLLHNAYQHS 396
Cdd:COG5806 259 TFAkpQPEKLEKIdvseeLEHVIDVLSPY---------ANMNN--VEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAM 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 397 LENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGV 476
Cdd:COG5806 328 PNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGK 401
|
....*....
gi 806951658 477 GTTFIIELP 485
Cdd:COG5806 402 GTTFTITLP 410
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-468 |
6.96e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 93.16 E-value: 6.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSleNTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEI 460
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
....*...
gi 806951658 461 VELHNGAI 468
Cdd:cd16949 79 IEQHGGKI 86
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
270-485 |
8.30e-23 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 102.06 E-value: 8.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 270 LAS-VAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVqleqhqfviKKQKVLLRPF-LE 347
Cdd:PRK13837 453 LASgIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFG---------RKGERNTKPFdLS 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 RMVEKTKTTLTnKQMQLHVyckdDLEVCIDERRM---------EQVMLNLLHNAYQHSLENTTITIRVLAETNSFT---- 414
Cdd:PRK13837 524 ELVTEIAPLLR-VSLPPGV----ELDFDQDQEPAvvegnpaelQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRAPkvls 598
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 415 -----------ISVQDEGEGIPEEDIPHIFDRFYRvdksrTRAtGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIE 483
Cdd:PRK13837 599 hgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFT-----TRA-GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVY 672
|
..
gi 806951658 484 LP 485
Cdd:PRK13837 673 LP 674
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
241-485 |
1.09e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 98.82 E-value: 1.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 241 RNDELGSLAKTIEDLSSELTYMKKERNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREeYLQIIEDETDSVTDLVQ 320
Cdd:PRK11466 419 RTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRD-DLRAITDSGESLLTILN 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 321 DL--FMLVQLEQHQFVIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHVYCKDDLEVCI--DERRMEQVMLNLLHNAYQHS 396
Cdd:PRK11466 498 DIldYSAIEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALmgDPRRIRQVITNLLSNALRFT 577
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 397 lENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRtratGGKGIGLAVAKEIVELHNGAILVTSKLGV 476
Cdd:PRK11466 578 -DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEV 652
|
....*....
gi 806951658 477 GTTFIIELP 485
Cdd:PRK11466 653 GSCFCLRLP 661
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-485 |
1.39e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 89.41 E-value: 1.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSleNTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEI 460
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 806951658 461 VELHNG-AILVTSKLGvGTTFIIELP 485
Cdd:cd16939 79 ALWHGGhVECDDSELG-GACFRLTWP 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-485 |
5.99e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 87.44 E-value: 5.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTraTGGKGIGLAVAKEI 460
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 806951658 461 VELHNGAILVTSkLGVGTTFIIELP 485
Cdd:cd16923 79 IELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
179-466 |
5.63e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 91.18 E-value: 5.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 179 SFLENMLLKLMNQ--------------FLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKLN-TPIQLgikRND 243
Cdd:PRK10755 36 QLLVQATLSARNNdehvmkeireavasLLVPSLVMVSLTLLICFQAVRWITRPLAELQKELEARTADNlTPIAI---HSS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 244 --ELGSLAKTIEDLSSELTY-MKKERnEFLASVAHELLTPLtymkgyAKVakRDTLtkeEREEYLQIIE-----DETDSV 315
Cdd:PRK10755 113 tlEIEAVTSALNQLVSRLTStLDQER-LFTADVAHELRTPL------AGI--RLHL---ELLEKQHHIDvapliARLDQM 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 316 TDLVQDLFMLVQLEQ------HQFVIKKQKVL--LRPFLERMVEKTKTTLTNKQMQLHVYCKDDlevcideRRMEQVML- 386
Cdd:PRK10755 181 MHTVEQLLQLARAGQsfssghYQTVKLLEDVIlpSQDELSEMLEQRQQTLLLPESAADITVQGD-------ATLLRLLLr 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 387 NLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDkSRtraTGGKGIGLAVAKEIVELHNG 466
Cdd:PRK10755 254 NLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHG 329
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-485 |
1.74e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 83.53 E-value: 1.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNA--YQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDkSRTrATGGKGIGLAVAK 458
Cdd:cd16921 1 LGQVLTNLLGNAikFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SRE-EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 806951658 459 EIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
387-485 |
3.71e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 82.34 E-value: 3.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 387 NLLHNAYQHSL----ENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRvdksrTRATGGKGIGLAVAKEIVE 462
Cdd:cd16915 7 NLIDNALDALAatgaPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 806951658 463 LHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
266-487 |
5.48e-19 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 90.56 E-value: 5.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 266 RNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPF 345
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 346 LERMVEKTKTTLTNKQMQLHVYCK--DDLEVCIDERRMEQVMLNLLHNAYQHSLEN----TTITIRVLAETNSFTISVQD 419
Cdd:PRK09959 792 VQNTCHSFGAIAASKSIALSCSSTfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGavkiTTSLGHIDDNHAVIKMTIMD 871
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 420 EGEGIPEEDIPHIFDRFYRVDKSRTRAtgGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:PRK09959 872 SGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
270-485 |
1.34e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 88.07 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 270 LASVAHELLTPLTYMKGYAKVAKRDTltKEEREeyLQIIEDETDSVTDLVQDLFML--VQLEQHqfvikkqkvLLRPFL- 346
Cdd:PRK09470 247 LSDISHELRTPLTRLQLATALLRRRQ--GESKE--LERIETEAQRLDSMINDLLVLsrNQQKNH---------LERETFk 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 347 -----ERMVEKTKTTLtnKQMQLHVYCKDDLE---VCIDERRMEQVMLNLLHNAYQHSleNTTITIRVLAETNSFTISVQ 418
Cdd:PRK09470 314 anslwSEVLEDAKFEA--EQMGKSLTVSAPPGpwpINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVD 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 419 DEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVT-SKLGvGTTFIIELP 485
Cdd:PRK09470 390 DDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEdSPLG-GLRLTIWLP 456
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-485 |
2.43e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 80.19 E-value: 2.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSleNTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTraTGGKGIGLAVAKEI 460
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 806951658 461 VELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
252-487 |
4.61e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 86.06 E-value: 4.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 252 IEDLSSELTYMKkERNEFLASVAHELLTPLTYMKGYAKVAKRDtltkeEREEYLQIIEDETDSVTDlvqdlfmlvqleqh 331
Cdd:COG3290 176 LERLEEELEGVK-ELAEALRAQRHDFRNHLHTISGLLQLGEYD-----EALEYIDEISEELQELID-------------- 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 332 qFVIKKQK-VLLRPFLERMVEKTKttltNKQMQLHVYCKDDLEV-CIDERRMEQVMLNLLHNAYQHSLENT----TITIR 405
Cdd:COG3290 236 -SLLSRIGnPVLAALLLGKAARAR----ERGIDLTIDIDSDLPDlPLSDTDLVTILGNLLDNAIEAVEKLPeeerRVELS 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 406 VLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRvdksrTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:COG3290 311 IRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
..
gi 806951658 486 FE 487
Cdd:COG3290 386 KE 387
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-485 |
5.19e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 79.54 E-value: 5.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 383 QVMLNLLHNAYQHSLENTT-ITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrVDKSRTRATG-GKGIGLAVAKEI 460
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISRQI 81
|
90 100
....*....|....*....|....*....
gi 806951658 461 VELHNGAILVTSK----LGVGTTFIIELP 485
Cdd:cd16953 82 IEAHGGISVAENHnqpgQVIGARFTVQLP 110
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-485 |
6.81e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.98 E-value: 6.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAY----QHSLENTTITIRVL-AETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSrtratgGKGIGLA 455
Cdd:cd16920 1 IQQVLINLVRNGIeamsEGGCERRELTIRTSpADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 806951658 456 VAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-484 |
1.07e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 79.21 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEqVMLNLLHNAYQHSLENTTITIRVLAEtnSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTratgGKGIGLAVAKEI 460
Cdd:cd16954 39 ME-LLGNLLDNACKWCLEFVEVTARQTDG--GLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEI 111
|
90 100
....*....|....*....|....*
gi 806951658 461 VELHNGAILVT-SKLGvGTTFIIEL 484
Cdd:cd16954 112 VEQYGGELSLSdSPLG-GARFEVVF 135
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
178-471 |
2.23e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 84.19 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 178 TSFLENMLLKLMNQFLIISVLTVIlttiSVFVFSRVITEPLIKMKRATEKMSKLNTPIQLGIKRNDELGSLAKTIEDLSS 257
Cdd:PRK09467 145 TEIHQGDFSPLFRYTLAIGLLSVA----GGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAA 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 258 ELTYMKKERNEFLASVAHELLTPLTymkgyakvakRDTLTKE---EREEYLQ--IIED--ETDSVTDLVQDLFMLVQLEQ 330
Cdd:PRK09467 221 GIKQLEDDRTLLMAGVSHDLRTPLT----------RIRLATEmmsEEDGYLAesINKDieECNAIIEQFIDYLRTGQEMP 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 331 HQFV----IKKQKVLLRPFLERMVEktkTTLtnkqmqlhvyCKDDLEVCIDERRMEQVMLNLLHNAYQHSleNTTITIRV 406
Cdd:PRK09467 291 MEMAdlnaLLGEVIAAESGYEREIE---TAL----------QPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSS 355
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 806951658 407 LAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTraTGGKGIGLAVAKEIVELHNGAILVT 471
Cdd:PRK09467 356 GTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELG 418
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
193-485 |
1.42e-16 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 82.43 E-value: 1.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 193 LIISVLTVILTTISVFVF--SRVITEPLIKMKRATEKMSK--LNTPIQlgIKRNDELGSLAKT----------------- 251
Cdd:COG4192 328 LLAIALLSLLLAVLINYFyvRRRLVKRLNALSDAMAAIAAgdLDVPIP--VDGNDEIGRIARLlrvfrdqaiektqelet 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 252 -IEDLSSELTYMKKERNEF------------LASVAHELLTPLTYMKGYAKVAKRDTLTK--EEREEYLQIIEDETDSVT 316
Cdd:COG4192 406 eIEERKRIEKNLRQTQDELiqaakmavvgqtMTSLAHELNQPLNAMSMYLFSAKKALEQEnyAQLPTSLDKIEGLIERMD 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 317 DLVQDLfmlvqleqHQFVIKK----QKVLLRPFLERMVEKTKTTLTNKQMQLHVYckDDLEVCIDERRMEQVMLNLLHNA 392
Cdd:COG4192 486 KIIKSL--------RQFSRKSdtplQPVDLRQVIEQAWELVESRAKPQQITLHIP--DDLMVQGDQVLLEQVLVNLLVNA 555
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 393 YQHSLENTTITIRVLAETNSFTISVQDEGEGIPeeDIPHIFDRFYrvdksrTRATGGKGIGLAVAKEIVELHNGAILVTS 472
Cdd:COG4192 556 LDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
|
330
....*....|...
gi 806951658 473 KLGVGTTFIIELP 485
Cdd:COG4192 628 TLERGAMVILEFN 640
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-484 |
1.61e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 75.63 E-value: 1.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAV 456
Cdd:cd16947 17 NTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTI 96
|
90 100
....*....|....*....|....*...
gi 806951658 457 AKEIVELHNGAILVTSKLGVGTTFIIEL 484
Cdd:cd16947 97 TKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
387-478 |
4.85e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 73.98 E-value: 4.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 387 NLLHNAYQHSLENTTITIRVLAETNSfTISVQDEGEGIPEEDIPHIFDRFYRVDKsrtRATGGKGIGLAVAKEIVELHNG 466
Cdd:cd16940 20 NLVDNAVRYSPQGSRVEIKLSADDGA-VIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRIVELHGG 95
|
90
....*....|..
gi 806951658 467 AILVTSKLGVGT 478
Cdd:cd16940 96 QIFLGNAQGGGL 107
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
171-487 |
1.38e-15 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 78.91 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 171 KLYMLLKTSFLENMLLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKLNTpIQLGIKRNDELGSLAK 250
Cdd:COG2972 138 TLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILAR 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 251 TIEDLSSELTYMKKERNEflasvahelltpltymkgyakvakrdtLTKEERE---EYLQ------------------IIE 309
Cdd:COG2972 217 SFNEMVERIKELIEEVYE---------------------------LELEKKEaelKALQaqinphflfntlnsirwlAEL 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 310 DETDSVTDLVQDLfmlVQLEQHQFVIKKQKVLLR---PFLERMVEKTKTTLTNKqMQLHVYCKDDLEVCIDERRMEQVml 386
Cdd:COG2972 270 EDPEEAEEMLEAL---SKLLRYSLSKGDELVTLEeelELIKSYLEIQKLRFGDR-LEVEIEIDEELLDLLIPKLILQP-- 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 387 nLLHNAYQHSLENT----TITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFyrvdksrTRATGGKGIGLAVAKEIVE 462
Cdd:COG2972 344 -LVENAIEHGIEPKegggTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLK 415
|
330 340
....*....|....*....|....*...
gi 806951658 463 LHNGA---ILVTSKLGVGTTFIIELPFE 487
Cdd:COG2972 416 LYYGEeygLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-484 |
2.36e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 71.72 E-value: 2.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQ--HSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdksRTRATG-GKGIGLAVA 457
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 806951658 458 KEIVELHNGAILVTSKLGVGTTFIIEL 484
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-468 |
3.83e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.34 E-value: 3.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdkSRTRATGGK---GIGLAVA 457
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY----SLPRPHSGQkstGLGLAFV 80
|
90
....*....|.
gi 806951658 458 KEIVELHNGAI 468
Cdd:cd16945 81 QEVAQLHGGRI 91
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
258-487 |
1.14e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 76.81 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 258 ELTYMKKE-------RNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREeYLQIIEDETDSVTDLVQDLFMLVQLEQ 330
Cdd:PRK11107 278 ELDLAKKRaqeaariKSEFLANMSHELRTPLNGVIGFTRQTLKTPLTPTQRD-YLQTIERSANNLLAIINDILDFSKLEA 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 331 HQFVIKKQkvllrPF-LERMVEKTKTTLTN----KQMQLHVYCKDDL--EVCIDERRMEQVMLNLLHNAYQHSlENTTIT 403
Cdd:PRK11107 357 GKLVLENI-----PFsLRETLDEVVTLLAHsaheKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFT-ESGNID 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 404 IRV---LAETNSFTISVQ--DEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGT 478
Cdd:PRK11107 431 ILVelrALSNTKVQLEVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGS 510
|
....*....
gi 806951658 479 TFIIELPFE 487
Cdd:PRK11107 511 TFWFHLPLD 519
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
269-485 |
1.27e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 76.55 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 269 FLASVAHELLTPLtymkgYAKVAKRDTL-TKEEREE--------------YLQIIEDETDsvtdlvqdlFMLVQLEQhqf 333
Cdd:PRK10841 450 FLATVSHELRTPL-----YGIIGNLDLLqTKELPKGvdrlvtamnnssslLLKIISDILD---------FSKIESEQ--- 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 334 vikkQKVLLRPFLERMVEKTKTT-----LTNKQMQLHVYCKDDLEVCI--DERRMEQVMLNLLHNAYQHSlENTTITIRV 406
Cdd:PRK10841 513 ----LKIEPREFSPREVINHITAnylplVVKKRLGLYCFIEPDVPVALngDPMRLQQVISNLLSNAIKFT-DTGCIVLHV 587
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806951658 407 LAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK10841 588 RVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
381-475 |
1.35e-14 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 75.82 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEqVMLNLLHNAYQHSLENTTITIRVlaETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTratgGKGIGLAVAKEI 460
Cdd:PRK10815 380 ME-VMGNVLDNACKYCLEFVEISARQ--TDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREI 452
|
90
....*....|....*.
gi 806951658 461 VELHNGAILVT-SKLG 475
Cdd:PRK10815 453 TEQYEGKISAGdSPLG 468
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-485 |
4.06e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 68.47 E-value: 4.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFY--RVDKSRTRATggkGIGL 454
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgENGRNFQEST---GMGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 806951658 455 AVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16948 79 YLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-485 |
7.41e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 67.81 E-value: 7.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQhSLENT--TITIRVLAETN----------SFTISVQDEGEGIPeediPHIFDR-FYRVDKSRTrat 447
Cdd:cd16918 1 LIQVFLNLVRNAAQ-ALAGSggEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIP----PDLQDTiFYPMVSGRE--- 72
|
90 100 110
....*....|....*....|....*....|....*...
gi 806951658 448 GGKGIGLAVAKEIVELHNGAILVTSKLGvGTTFIIELP 485
Cdd:cd16918 73 NGTGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
264-325 |
9.73e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 65.70 E-value: 9.73e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 806951658 264 KERNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFML 325
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDL 63
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
268-485 |
3.78e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 70.49 E-value: 3.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 268 EFLASVAHELLTPLTYMKGYAKVAKRdTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFvikkQKvlLRPFLE 347
Cdd:PRK11073 132 DLVRGLAHEIKNPLGGLRGAAQLLSK-ALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVT----ES--IHKVAE 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 RMVEktkttLTNKQMQLHVYCKDDL-----EVCIDERRMEQVMLNLLHNAYQH-SLENTTITIRV--------------L 407
Cdd:PRK11073 205 RVVQ-----LVSLELPDNVRLIRDYdpslpELAHDPDQIEQVLLNIVRNALQAlGPEGGTITLRTrtafqltlhgeryrL 279
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806951658 408 AETnsftISVQDEGEGIPeediPHIFDR-FYRVDKSRTratGGKGIGLAVAKEIVELHNGAILVTSKLGvGTTFIIELP 485
Cdd:PRK11073 280 AAR----IDIEDNGPGIP----PHLQDTlFYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLP 346
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-468 |
5.31e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.18 E-value: 5.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYRVDKSRtRATGGKGIGLAV 456
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|..
gi 806951658 457 AKEIVELHNGAI 468
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
265-330 |
9.82e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 63.00 E-value: 9.82e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 806951658 265 ERNEFLASVAHELLTPLTYMKGYAKVAkRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQ 330
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELL-RDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
265-330 |
4.14e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 61.43 E-value: 4.14e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 806951658 265 ERNEFLASVAHELLTPLTYMKGYAKVAKRDTLTkEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQ 330
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
387-487 |
9.47e-12 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 67.25 E-value: 9.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 387 NLLHNAYQ--HSLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdksrtrATGGK--GIGLAVAKEIVE 462
Cdd:PRK11086 440 NLIENALEavGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY--------STKGSnrGVGLYLVKQSVE 511
|
90 100
....*....|....*....|....*
gi 806951658 463 LHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:PRK11086 512 NLGGSIAVESEPGVGTQFFVQIPWD 536
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
243-464 |
4.40e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 64.67 E-value: 4.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 243 DELGSLAKTIEDLsseltyMKKERnEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDL 322
Cdd:PRK10337 221 EALNQLFARTHAM------MVRER-RFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 323 FMLVQLEQHQFVIKKQKVLLRPFLERMV-------EKTKTTLTnkqmqLHVyckDDLEVCiderRMEQVML------NLL 389
Cdd:PRK10337 294 LTLSRLDSLDNLQDVAEIPLEDLLQSAVmdiyhtaQQAGIDVR-----LTL---NAHPVI----RTGQPLLlsllvrNLL 361
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 390 HNAYQHSLENTTITIRVLAetNSFTisVQDEGEGIPEEDIPHIFDRFYR---VDKSrtratgGKGIGLAVAKEIVELH 464
Cdd:PRK10337 362 DNAIRYSPQGSVVDVTLNA--RNFT--VRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLH 429
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
381-485 |
5.58e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 56.62 E-value: 5.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 381 MEQVMLNLLHNAYQHSLENTTITIRV---------------LAETNSFTISVQDEGEGIPEEDIPHIFDRFYRvdksrTR 445
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETsnqrvdadyalnyrdLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFT-----TK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 806951658 446 ATG-GKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-485 |
1.35e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.62 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQ--HSLENTTITIRVLAETN---SFTISVQDEGEGIPEEDIPHIFDRfYRVDKSRtratgGKG 451
Cdd:cd16944 1 DTTQISQVLTNILKNAAEaiEGRPSDVGEVRIRVEADqdgRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 806951658 452 IGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
185-484 |
1.14e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 57.43 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 185 LLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKLNTPIQLGIKRNDELGSLAKTIEDLSSEL-TYMK 263
Cdd:COG2770 207 ALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLrESIE 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 264 KERNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLR 343
Cdd:COG2770 287 EAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALE 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 344 PFLERMVEKTKTTLTNKQMQLHVYCKDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEG 423
Cdd:COG2770 367 LLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIA 446
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 806951658 424 IPEEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIEL 484
Cdd:COG2770 447 AAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAE 507
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
388-487 |
2.30e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 55.01 E-value: 2.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 388 LLHNAYQHSlENTTITIRVLAETNSFTISVQDEGEGIPEEDIPhifdrfyrvdksrtratgGKGIGLAVAKEIVELHNGA 467
Cdd:COG4585 170 ALTNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------------GGGLGLRGMRERAEALGGT 230
|
90 100
....*....|....*....|
gi 806951658 468 ILVTSKLGVGTTFIIELPFE 487
Cdd:COG4585 231 LTIGSAPGGGTRVRATLPLA 250
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
193-487 |
6.20e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 54.89 E-value: 6.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 193 LIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKLNTPIQLGIKRNDELGSLAKTIEDLSSELTYMKKE------- 265
Cdd:COG3850 121 LLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAEleeeeel 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 266 RNEFLASVAHELLTPLTYMKGYAKVAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPF 345
Cdd:COG3850 201 EAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 346 LERMVEKTKTTLTNKQMQLHVyckDDLEVCIDERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNSFTISVQDEGEGIP 425
Cdd:COG3850 281 LELELLALLLELVELLALAAA---EEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAA 357
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 806951658 426 EEDIPHIFDRFYRVDKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:COG3850 358 AGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVL 419
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
348-485 |
3.41e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 50.27 E-value: 3.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 348 RMVEKTKTTLtNKQMQLHVYCKD-DLEVCIDERrMEQVMLNLLHNAYQHSLENT------------TITIRVLAETNSFT 414
Cdd:cd16916 7 RLVRDLAREL-GKQVELVVEGEDtELDKSVLEK-LADPLTHLLRNAVDHGIEAPeerlaagkppegTITLRAEHQGNQVV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 415 ISVQDEGEGIPEEDIPHI-FDRFYRVDKSRTRAT----------------------GGKGIGLAVAKEIVELHNGAILVT 471
Cdd:cd16916 85 IEVSDDGRGIDREKIREKaIERGLITADEAATLSddevlnlifapgfstaeqvtdvSGRGVGMDVVKRSIESLGGTIEVE 164
|
170
....*....|....
gi 806951658 472 SKLGVGTTFIIELP 485
Cdd:cd16916 165 SEPGQGTTFTIRLP 178
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
273-485 |
3.44e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 52.75 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 273 VAHELLTPLTYMKGYAKV----AKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVqleqhqfviKKQKVLLRP---- 344
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDViqaaLSHPDADRGRMARSVENIRAAAERAATLTQQLLAFA---------RKQRLEGRVlnln 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 345 -FLERMVEKTKTTLtNKQMQLHVYCKDDLEVC-IDERRMEQVMLNLLHNAYQHSLENTTITIR---------------VL 407
Cdd:PRK13557 241 gLVSGMGELAERTL-GDAVTIETDLAPDLWNCrIDPTQAEVALLNVLINARDAMPEGGRVTIRtrnveiededlamyhGL 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806951658 408 AETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdksRTRATG-GKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK13557 320 PPGRYVSIAVTDTGSGMPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
370-455 |
3.79e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 49.14 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 370 DDLEVCIDErrmeqvmlnLLHNAYQHS---LENTTITIRVLAETNSFTISVQDEGEGIPEEDIPhifdrfyrvDKSRTRA 446
Cdd:COG2172 33 DDLVLAVSE---------AVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLA 94
|
....*....
gi 806951658 447 TGGKGIGLA 455
Cdd:COG2172 95 EGGRGLFLI 103
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
377-484 |
1.85e-06 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 47.07 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 377 DERRMEQVMLNLLHNAYQHSLENTTITIRVLAETNS-----------------------FTISVQDEGEG-IPEEDIPHI 432
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGGSedrsdrdwgpwrpsmsdesveirFEVEINDSGSPsIESASMRNS 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 806951658 433 FDRFYRVDKSrtratgGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIEL 484
Cdd:cd16938 88 LNRRYNLSEL------GEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
384-485 |
3.01e-06 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 47.34 E-value: 3.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 384 VMLNLLHNAYQHSLENTT--------ITIRVLAETNSFTISVQDEGEGIPEEDIPHIFDRFY-----------RVDKSRT 444
Cdd:cd16929 47 ILFELLKNAMRATVESHGddsddlppIKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfSDLISGT 126
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 806951658 445 RAT--GGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16929 127 QPSplAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
215-259 |
4.87e-06 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 43.59 E-value: 4.87e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 806951658 215 TEPLIKMKRATEKMSKLNTPIQLGIKRNDELGSLAKTIEDLSSEL 259
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
252-485 |
6.44e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 48.68 E-value: 6.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 252 IEDLSSELTYMKkERNEFLASVAHELLTPLTYMKGYakvakrdtLTKEEREEYLQIIEDETDSVTDLVQDLfmlvqleQH 331
Cdd:PRK15053 325 ISTLNAQLTQIK-QYVESLRTLRHEHLNWMSTLNGL--------LQMKEYDRVLEMVQGESQAQQQLIDSL-------RE 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 332 QFVIKKQKVLLRPFLERMVEKTKTTLTNKQMQLHvyckdDLEVCIDERRMEQVMLNLLHNAYQHSLE----NTTITIRVL 407
Cdd:PRK15053 389 AFADRQVAGLLFGKVQRARELGLKMVIVPGSQLS-----QLPPGLDSTEFAAIVGNLLDNAFEASLRsdegNKIVELFLS 463
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 408 AETNSFTISVQDEGEGIPEEDIPHIFDRFYrvdKSRTRATGGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELP 485
Cdd:PRK15053 464 DEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
266-487 |
1.13e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 48.00 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 266 RNEFLASVAHELLTPLTYMKGYAKvAKRDTLTKEEREEYLQIIEDETDSVTDLVQDLFMLVQLEQHQFVIKKQKVLLRPF 345
Cdd:PRK10618 450 RKAFLQNIGDELKQPLQSLAQLAA-QLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDL 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 346 LERMVEKTKTTLTNKQMQLHVYCKDDLEVCI--DERRMEQVMLNLLHnayqHSLENTT---ITIRVLAETNS---FTISV 417
Cdd:PRK10618 529 IDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRigDRDALRKILLLLLN----YAITTTAygkITLEVDQDESSpdrLTIRI 604
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806951658 418 QDEGEGIPEEDI---------PHIFDRFYRvdksrtratgGKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPFE 487
Cdd:PRK10618 605 LDTGAGVSIKELdnlhfpflnQTQGDRYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKML 673
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
388-486 |
3.93e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 45.94 E-value: 3.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 388 LLH---NAYQHSLENT------------TITIRVLAETNSFTISVQDEGEGIPEEDIphifdrfyrvdKSRTRATG---- 448
Cdd:COG0643 282 LVHlvrNAVDHGIETPeerlaagkpetgTITLSAYHEGGRVVIEVSDDGRGLDLEKI-----------RAKAIEKGlita 350
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 806951658 449 ------------------------------GKGIGLAVAKEIVELHNGAILVTSKLGVGTTFIIELPF 486
Cdd:COG0643 351 eeaaalsdeellelifapgfstaeevtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
338-487 |
7.03e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.28 E-value: 7.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 338 QKVLLRPFLERMVEKTKTTLTNKQMQLHVYCkDDLEVciderRMEQVM-----LN-LLHNAYQH---SLENTTITIRVLA 408
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDG-PDVEL-----PADAAVplgliLNeLVTNALKHaflSGEGGRIRVSWRR 430
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806951658 409 ETNSFTISVQDEGEGIPEEdiphifdrfyrVDKSRTratggKGIGLAVAKEIVELHNGAILVTSklGVGTTFIIELPFE 487
Cdd:COG3920 431 EDGRLRLTVSDNGVGLPED-----------VDPPAR-----KGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPLA 491
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
212-259 |
1.61e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 39.54 E-value: 1.61e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 806951658 212 RVITEPLIKMKRATEKMSKLNTPIQLGIKRNDELGSLAKTIEDLSSEL 259
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
388-485 |
2.42e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.49 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 388 LLHNAYQHSL----ENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHIfdrfyrvdkSRTRATGGKGIGLAVAKEIVEL 463
Cdd:cd16957 9 LVENAIRHAFpkrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLL---------GKTTVTSEKGTGTALENLNRRL 79
|
90 100
....*....|....*....|....*..
gi 806951658 464 HN-----GAILVTSKLGVGTTFIIELP 485
Cdd:cd16957 80 IGlfgseACLHIESEVHGGTEVWFVIP 106
|
|
| PRK04184 |
PRK04184 |
DNA topoisomerase VI subunit B; Validated |
397-473 |
3.28e-04 |
|
DNA topoisomerase VI subunit B; Validated
Pssm-ID: 235246 [Multi-domain] Cd Length: 535 Bit Score: 42.96 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 397 LENTTITI-RVLAETNSFTISVQDEGEGIPEEDIPHIF------DRFYRVDKSRtratGGKGIGLAVAKEIVELHNG-AI 468
Cdd:PRK04184 58 LPDIKIEIkRVDEGKDHYRVTVEDNGPGIPPEEIPKVFgkllygSKFHNLRQSR----GQQGIGISAAVLYAQMTTGkPV 133
|
....*
gi 806951658 469 LVTSK 473
Cdd:PRK04184 134 RVISS 138
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
413-457 |
3.54e-04 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 41.95 E-value: 3.54e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 806951658 413 FTISVQDEGEGIPEEDIPHIFDRFYRVDKSRTRATGGK-GIGLAVA 457
Cdd:cd16933 56 YKVIVEDNGPGIPEEQIPKVFGKVLYGSKYHNKQSRGQqGLGISAA 101
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-485 |
5.62e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 40.09 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 384 VMLNLLHNAYQHSL---ENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHifdrfyrvDKSRtratggkgIGLAVAKEI 460
Cdd:cd16951 43 VVNELLQNALKHAFsdrEGGTITIRSVVDGDYLRITVIDDGVGLPQDEDWP--------NKGS--------LGLQIVRSL 106
|
90 100
....*....|....*....|....*
gi 806951658 461 VELHNGAILVTSKLGVGTTFIIELP 485
Cdd:cd16951 107 VEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
361-454 |
7.87e-04 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 39.58 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 361 QMQLHVYCKDDLEVCIDErrmeqVMLNLLHNAYQHsLENTTITIRVLAETNSFTISVQDEGEGIPEEDIPHifdrFYRVD 440
Cdd:pfam13581 21 RAGLPEELLDEVELAVGE-----ACTNAVEHAYRE-GPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP----PDLEE 90
|
90
....*....|....
gi 806951658 441 KSRTRATGGKGIGL 454
Cdd:pfam13581 91 PDEDRKEGGRGLAL 104
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
185-259 |
9.68e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 41.54 E-value: 9.68e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 806951658 185 LLKLMNQFLIISVLTVILTTISVFVFSRVITEPLIKMKRATEKMSKLNTPIQLGIKRNDELGSLAKTIEDLSSEL 259
Cdd:COG0840 177 AALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
389-485 |
1.59e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 37.53 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806951658 389 LHNAYQHSlENTTITIRVLAETNSFTISVQDEGEGIPEEDIPhifdrfyrvdksrtratGGKGIGLAVAKEIVELHNGAI 468
Cdd:cd16917 9 LTNALKHA-GASRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 806951658 469 LVTSKLGVGTTFIIELP 485
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
186-259 |
8.40e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 38.68 E-value: 8.40e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806951658 186 LKLMNQFLIISV-LTVILTtISVFVFSRV---ITEPLIKMKRATEKMSKLN-TPIQLGIKRNDELGSLAKTIEDLSSEL 259
Cdd:PRK10935 145 RKLILLAAISLLgLILILT-LVFFTVRFTrrqVVAPLNQLVTASQQIEKGQfDHIPLDTTLPNELGLLAKAFNQMSSEL 222
|
|
| HATPase_MutL-MLH-PMS-like |
cd16926 |
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ... |
397-437 |
8.54e-03 |
|
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.
Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 37.42 E-value: 8.54e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 806951658 397 LEN------TTITIRVLAETNSFtISVQDEGEGIPEEDIPHIFDRFY 437
Cdd:cd16926 22 VENsidagaTRIDVEIEEGGLKL-IRVTDNGSGISREDLELAFERHA 67
|
|
| |
