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Conserved domains on  [gi|815720234|ref|WP_046451774|]
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16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA [Parabacteroides merdae]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 4-251 2.28e-118

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 339.41  E-value: 2.28e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:COG0030    9 LRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNlTVI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  83 AEDFLRLDLGKLFPDQ-FCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEV 161
Cdd:COG0030   89 EGDALKVDLPALAAGEpLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234 162 EYLFTVSENVFDPPPKVKSAVIRMVRNDRKSL-GCDEKLFKTVVKTSFNQRRKTLRNSMKPLLGKDCPDYSL------Pi 234
Cdd:COG0030  169 EILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVpVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALeaagidP- 247

                        250
                 ....*....|....*..
gi 815720234 235 fNKRPEQLSVEQFVELT 251
Cdd:COG0030  248 -TARAEELSVEEFARLA 263
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 4-251 2.28e-118

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 339.41  E-value: 2.28e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:COG0030    9 LRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNlTVI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  83 AEDFLRLDLGKLFPDQ-FCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEV 161
Cdd:COG0030   89 EGDALKVDLPALAAGEpLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234 162 EYLFTVSENVFDPPPKVKSAVIRMVRNDRKSL-GCDEKLFKTVVKTSFNQRRKTLRNSMKPLLGKDCPDYSL------Pi 234
Cdd:COG0030  169 EILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVpVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALeaagidP- 247

                        250
                 ....*....|....*..
gi 815720234 235 fNKRPEQLSVEQFVELT 251
Cdd:COG0030  248 -TARAEELSVEEFARLA 263
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 4-251 2.51e-96

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 282.97  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNlEII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   83 AEDFLRLDLGKLFPDQFCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEVE 162
Cdd:TIGR00755  81 EGDALKFDLNELAKDLTKVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  163 YLFTVSENVFDPPPKVKSAVIRMVRNDRKSLGCDEKLFKTVVKTSFNQRRKTLRNSMK---PLLGKDCPDYSLPIfNKRP 239
Cdd:TIGR00755 161 IVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPKDFALFEELLKAAFQQRRKTLRNNLKnllSELVELLEELGIDP-DKRV 239

                         250
                  ....*....|..
gi 815720234  240 EQLSVEQFVELT 251
Cdd:TIGR00755 240 EQLSPEDFLRLA 251
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
4-250 2.69e-71

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 219.39  E-value: 2.69e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNvEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  83 AEDFLRLDlgklFPDQFCVIGNYPYNISSQIFFKVLDYKehIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEVE 162
Cdd:PRK14896  81 EGDALKVD----LPEFNKVVSNLPYQISSPITFKLLKHG--FEPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234 163 YLFTVSENVFDPPPKVKSAVIRMVRNDRKSLGCDEKLFKTVVKTSFNQRRKTLRNSMK---PLLGKDCPDY-----SLPI 234
Cdd:PRK14896 155 IVEKVPPGAFSPKPKVDSAVVRLTPREPKYEVYDEDFFDDFVKALFQHRRKTLRNALKnsaHISGKEDIKAvvealPEEL 234

                        250
                 ....*....|....*.
gi 815720234 235 FNKRPEQLSVEQFVEL 250
Cdd:PRK14896 235 LNKRVFQLSPEEIAEL 250
rADc smart00650
Ribosomal RNA adenine dimethylases;
20-187 1.33e-57

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 181.17  E-value: 1.33e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    20 IAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KILAEDFLRLDLGKLFPdq 98
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNlTVIHGDALKFDLPKLQP-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    99 FCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEVEYLFTVSENVFDPPPKV 178
Cdd:smart00650  79 YKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKV 158


                   ....*....
gi 815720234   179 KSAVIRMVR 187
Cdd:smart00650 159 DSAVVRLER 167
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
5-250 4.51e-50

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 165.23  E-value: 4.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    5 KPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KILA 83
Cdd:pfam00398   3 KFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENlTVIH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   84 EDFLRLDLGKLFP---DQFCVIGNYPYNISSQIFFKVLDykEHIPCCSGM---IQKEVAERLAAGPGSKTYGILSVLLQA 157
Cdd:pfam00398  83 QDFLKFEFPSLVThihQEFLVVGNLPYNISTPIVKQLLF--ESRFGIVDMllmLQKEFARRLLARPGSKLYSRLSVLRQA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  158 WYEVEYLFTVSENVFDPPPKVKSAVIRMVRND-RKSLGCDEKLFKTVVKTSFNQRRKTLRNSMKPLLGKDCPDYSLPIF- 235
Cdd:pfam00398 161 FTDVKLVAKVPPSIFSPPPKVDSALVRLERHDpDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQAFSSHGi 240

                         250
                  ....*....|....*..
gi 815720234  236 --NKRPEQLSVEQFVEL 250
Cdd:pfam00398 241 ndNALVKKLSPEQTLDI 257
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 4-251 2.28e-118

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 339.41  E-value: 2.28e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:COG0030    9 LRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNlTVI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  83 AEDFLRLDLGKLFPDQ-FCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEV 161
Cdd:COG0030   89 EGDALKVDLPALAAGEpLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234 162 EYLFTVSENVFDPPPKVKSAVIRMVRNDRKSL-GCDEKLFKTVVKTSFNQRRKTLRNSMKPLLGKDCPDYSL------Pi 234
Cdd:COG0030  169 EILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVpVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALeaagidP- 247

                        250
                 ....*....|....*..
gi 815720234 235 fNKRPEQLSVEQFVELT 251
Cdd:COG0030  248 -TARAEELSVEEFARLA 263
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 4-251 2.51e-96

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 282.97  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNlEII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   83 AEDFLRLDLGKLFPDQFCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEVE 162
Cdd:TIGR00755  81 EGDALKFDLNELAKDLTKVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  163 YLFTVSENVFDPPPKVKSAVIRMVRNDRKSLGCDEKLFKTVVKTSFNQRRKTLRNSMK---PLLGKDCPDYSLPIfNKRP 239
Cdd:TIGR00755 161 IVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPKDFALFEELLKAAFQQRRKTLRNNLKnllSELVELLEELGIDP-DKRV 239

                         250
                  ....*....|..
gi 815720234  240 EQLSVEQFVELT 251
Cdd:TIGR00755 240 EQLSPEDFLRLA 251
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
4-250 2.69e-71

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 219.39  E-value: 2.69e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   4 VKPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KIL 82
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNvEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  83 AEDFLRLDlgklFPDQFCVIGNYPYNISSQIFFKVLDYKehIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEVE 162
Cdd:PRK14896  81 EGDALKVD----LPEFNKVVSNLPYQISSPITFKLLKHG--FEPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234 163 YLFTVSENVFDPPPKVKSAVIRMVRNDRKSLGCDEKLFKTVVKTSFNQRRKTLRNSMK---PLLGKDCPDY-----SLPI 234
Cdd:PRK14896 155 IVEKVPPGAFSPKPKVDSAVVRLTPREPKYEVYDEDFFDDFVKALFQHRRKTLRNALKnsaHISGKEDIKAvvealPEEL 234

                        250
                 ....*....|....*.
gi 815720234 235 FNKRPEQLSVEQFVEL 250
Cdd:PRK14896 235 LNKRVFQLSPEEIAEL 250
rADc smart00650
Ribosomal RNA adenine dimethylases;
20-187 1.33e-57

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 181.17  E-value: 1.33e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    20 IAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KILAEDFLRLDLGKLFPdq 98
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNlTVIHGDALKFDLPKLQP-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    99 FCVIGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQAWYEVEYLFTVSENVFDPPPKV 178
Cdd:smart00650  79 YKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKV 158


                   ....*....
gi 815720234   179 KSAVIRMVR 187
Cdd:smart00650 159 DSAVVRLER 167
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
5-250 4.51e-50

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 165.23  E-value: 4.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234    5 KPKKALGQHFLKDLQIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEG-KILA 83
Cdd:pfam00398   3 KFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENlTVIH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   84 EDFLRLDLGKLFP---DQFCVIGNYPYNISSQIFFKVLDykEHIPCCSGM---IQKEVAERLAAGPGSKTYGILSVLLQA 157
Cdd:pfam00398  83 QDFLKFEFPSLVThihQEFLVVGNLPYNISTPIVKQLLF--ESRFGIVDMllmLQKEFARRLLARPGSKLYSRLSVLRQA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  158 WYEVEYLFTVSENVFDPPPKVKSAVIRMVRND-RKSLGCDEKLFKTVVKTSFNQRRKTLRNSMKPLLGKDCPDYSLPIF- 235
Cdd:pfam00398 161 FTDVKLVAKVPPSIFSPPPKVDSALVRLERHDpDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQAFSSHGi 240

                         250
                  ....*....|....*..
gi 815720234  236 --NKRPEQLSVEQFVEL 250
Cdd:pfam00398 241 ndNALVKKLSPEQTLDI 257
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 8-216 1.17e-34

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 125.89  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234   8 KALGQHFLKDLQIAERIADTlSDYKQLP-VLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYL---------EQNFPVL 77
Cdd:PTZ00338  12 KKFGQHILKNPLVLDKIVEK-AAIKPTDtVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELkkrfqnsplASKLEVI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  78 EGkilaeDFLRLDLGKLfpdQFCViGNYPYNISSQIFFKVLDYKEHIPCCSGMIQKEVAERLAAGPGSKTYGILSVLLQA 157
Cdd:PTZ00338  91 EG-----DALKTEFPYF---DVCV-ANVPYQISSPLVFKLLAHRPLFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQL 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234 158 WYEVEYLFTVSENVFDPPPKVKSAVIRMV-RNDRKSLGCDEklFKTVVKTSFNQRRKTLR 216
Cdd:PTZ00338 162 LCRVTHLMKVSKNSFNPPPKVESSVVRIEpKNPPPDVDFEE--WDGLLRICFSRKNKTLS 219
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
21-102 4.27e-09

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 54.83  E-value: 4.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  21 AERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGH---DLTVVELDIESVDYLEQNFP---VLEGkiLAEDFLRLdLGKL 94
Cdd:COG3963   34 ARAMASEVDWSGAGPVVELGPGTGVFTRAILARGVpdaRLLAVEINPEFAEHLRRRFPrvtVVNG--DAEDLAEL-LAEH 110


                 ....*...
gi 815720234  95 FPDQFCVI 102
Cdd:COG3963  111 GIGKVDAV 118
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 17-142 1.63e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.16  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815720234  17 DLQIAERIADTLSDYKQlpVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQNFPVLEGKILAEDFLRLDLGklfP 96
Cdd:COG2227   11 DRRLAALLARLLPAGGR--VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVDFVQGDLEDLPLE---D 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 815720234  97 DQFCVIgnypynissqIFFKVLdykEHIPCCSGMIQkEVAERLAAG 142
Cdd:COG2227   86 GSFDLV----------ICSEVL---EHLPDPAALLR-ELARLLKPG 117
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
19-94 1.30e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.83  E-value: 1.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 815720234  19 QIAERIADTLSDYKQLPVLEIGPGMGVLTQFLLEKGHDLTVVELDIESVDYLEQnfpvlegKILAEDFLRLDLGKL 94
Cdd:COG4976   33 LLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKARE-------KGVYDRLLVADLADL 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 36-98 2.83e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.39  E-value: 2.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 815720234   36 VLEIGPGMGVLTQFLLEK-GHDLTVVELDIESVDYLEQNFPVLEGKIlaeDFLRLDLGKL-FPDQ 98
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNV---EFVQGDAEDLpFPDG 62
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 37-102 4.01e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.81  E-value: 4.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 815720234   37 LEIGPGMGVLTQFLLEKGHDLTVVELDI--ESVDYLEQNFPVLEGKILAE-DFLRLDLGKLFPDQFCVI 102
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDIspAALEAARERLAALGLLNAVRvELFQLDLGELDPGSFDVV 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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