|
Name |
Accession |
Description |
Interval |
E-value |
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
7-432 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 814.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 7 PADWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGAL 86
Cdd:COG2873 3 EKKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 87 ALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLG 166
Cdd:COG2873 83 ATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 167 NITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEhAERFRRLNE 246
Cdd:COG2873 163 DVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAA-NGKFPELTE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 247 PDVSYHGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYS 326
Cdd:COG2873 242 PDPSYHGLVYTEAFGNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 327 GLPEHRDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVRE 406
Cdd:COG2873 322 GLPSHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTP 401
|
410 420
....*....|....*....|....*.
gi 817518611 407 ETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:COG2873 402 DLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
12-431 |
0e+00 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 682.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 12 LDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASG 91
Cdd:PRK06084 3 LETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 92 QAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDI 171
Cdd:PRK06084 83 MAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 172 AALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEHAERFRRLNEPDVSY 251
Cdd:PRK06084 163 QALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKERFALLNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 252 HGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEH 331
Cdd:PRK06084 243 HGVTYTEAFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 332 RDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRL 411
Cdd:PRK06084 323 PEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRL 402
|
410 420
....*....|....*....|
gi 817518611 412 SIGIEHLDDLLADLAQALEA 431
Cdd:PRK06084 403 SIGIEHIDDIIADLAQALDA 422
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
11-430 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 679.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 11 HLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALAS 90
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 91 GQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITD 170
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 171 IAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEhaERFRRLNEPDVS 250
Cdd:TIGR01326 161 IEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNN--GRFPLFTTPDPS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 251 YHGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPE 330
Cdd:TIGR01326 239 YHGLVFTETLGNPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLAS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 331 HRDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:TIGR01326 319 HPHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIR 398
|
410 420
....*....|....*....|
gi 817518611 411 LSIGIEHLDDLLADLAQALE 430
Cdd:TIGR01326 399 LSVGIENIDDIIADLEQALE 418
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
10-431 |
0e+00 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 594.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 10 WHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALA 89
Cdd:PRK08248 7 FRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 90 SGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNIT 169
Cdd:PRK08248 87 SGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 170 DIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEhAERFRRLNEPDV 249
Cdd:PRK08248 167 DIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWKG-SGKFPGLTEPDP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 250 SYHGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLP 329
Cdd:PRK08248 246 SYHGLVYTDAVGEAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLP 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 330 EHRDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETV 409
Cdd:PRK08248 326 SHPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLV 405
|
410 420
....*....|....*....|..
gi 817518611 410 RLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK08248 406 RLSVGTEAIDDILDDLRQAIRQ 427
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-432 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 583.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 1 MTTAREPADWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLE 80
Cdd:PRK07812 3 STDADPTANWSFETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 81 GGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRF-ADPREPDSFAALIDARTKAIFVE 159
Cdd:PRK07812 83 GGVAALLLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFvEDPDDLDAWRAAVRPNTKAFFAE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 160 SVGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEhaE 239
Cdd:PRK07812 163 TISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQ--G 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 240 RFRRLNEPDVSYHGVVYTEaFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGK 319
Cdd:PRK07812 241 RFPGFTTPDPSYHGVVFAE-LGPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 320 VEWVDYSGLPEHRDHALAQRYLSgRGPG-ILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEE 398
Cdd:PRK07812 320 VASVNYAGLPSSPWYERAKRLAP-KGTGaVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEE 398
|
410 420 430
....*....|....*....|....*....|....
gi 817518611 399 LAKAGVREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK07812 399 QLATGVTPGLVRLAVGIEGIDDILADLEAGFAAA 432
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
12-432 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 560.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 12 LDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASG 91
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 92 QAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDI 171
Cdd:PRK05994 88 HAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 172 AALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEHAeRFRRLNEPDVSY 251
Cdd:PRK05994 168 AAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSKSG-KYPMLSEPRPEY 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 252 HGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEH 331
Cdd:PRK05994 247 HGLVLHETFGNFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDD 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 332 RDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRL 411
Cdd:PRK05994 327 PYHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRL 406
|
410 420
....*....|....*....|.
gi 817518611 412 SIGIEHLDDLLADLAQALEAV 432
Cdd:PRK05994 407 SIGIEDVDDIIADLEQALAKA 427
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-431 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 516.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 7 PADWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGAL 86
Cdd:PRK08134 4 MSPPGFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 87 ALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLG 166
Cdd:PRK08134 84 ATASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 167 NITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWaEHAERFRRLNE 246
Cdd:PRK08134 164 EVLDIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDW-EASGKFPELTE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 247 PDVSYHGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYS 326
Cdd:PRK08134 243 PYAGFHGMVFAEESTVAAFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 327 GLPEHRDHALAQRYLSgRGPG-ILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVR 405
Cdd:PRK08134 323 ELESHPDHALAKRLLP-RGAGsVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIG 401
|
410 420
....*....|....*....|....*.
gi 817518611 406 EETVRLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK08134 402 EGTIRLSIGLEDADDLIDDLKRALKA 427
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
10-432 |
4.40e-176 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 497.26 E-value: 4.40e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 10 WHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALA 89
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 90 SGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNIT 169
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 170 DIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrFRWAEHAERFRRLnepdv 249
Cdd:COG0626 161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVV----GRDEELAERLRFL----- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 250 syhgvvyteafgeaayigrarvvpLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLP 329
Cdd:COG0626 232 ------------------------QNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLP 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 330 EHRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETV 409
Cdd:COG0626 288 SHPGHELAKRQMSGFG-GMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLV 366
|
410 420
....*....|....*....|...
gi 817518611 410 RLSIGIEHLDDLLADLAQALEAV 432
Cdd:COG0626 367 RLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
29-430 |
3.09e-172 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 486.71 E-value: 3.09e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 29 AAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAEAGDN 108
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 109 LVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD 188
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 189 NTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGrfrwAEHAERFRRLnepdvsyhgvvyteafgeaayigr 268
Cdd:cd00614 162 NTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSG----EALIQRLRFL------------------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 269 arvvpLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHRDHALAQRYLSGRGpGI 348
Cdd:cd00614 214 -----RLALGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYG-GV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 349 LTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLSIGIEHLDDLLADLAQA 428
Cdd:cd00614 288 FSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQA 367
|
..
gi 817518611 429 LE 430
Cdd:cd00614 368 LK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
13-430 |
1.28e-167 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 475.18 E-value: 1.28e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 13 DTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDdtqhgadlFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQ 92
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 93 AAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIA 172
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 173 ALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGrFRWAEHAERFrrlnepdvsyh 252
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNG-EELGKELYFL----------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 253 gvvyteafgeaayigrarvvpLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHR 332
Cdd:pfam01053 221 ---------------------QNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 333 DHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLS 412
Cdd:pfam01053 280 GHELAKRQMKGFG-GMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLS 358
|
410
....*....|....*...
gi 817518611 413 IGIEHLDDLLADLAQALE 430
Cdd:pfam01053 359 VGIEDVDDLIADLKQALE 376
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
6-432 |
3.01e-141 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 410.80 E-value: 3.01e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 6 EPADWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGA 85
Cdd:PRK05613 8 NADQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 86 LALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFA-DPREPDSFAALIDARTKAIFVESVGNP 164
Cdd:PRK05613 88 VAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 165 LGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAehAER---- 240
Cdd:PRK05613 168 QADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWT--VERdgkp 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 241 -FRRLNEPDVSYHGVVYTEaFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGK 319
Cdd:PRK05613 246 vFPYFVTPDPAYHGLKYAD-LGAPAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEK 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 320 VEWVDYSGLPEHRDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEEL 399
Cdd:PRK05613 325 VAKVNFAGLKDSPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGL 404
|
410 420 430
....*....|....*....|....*....|...
gi 817518611 400 AKAGVREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK05613 405 ARAGITQATVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
10-429 |
2.64e-129 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 380.17 E-value: 2.64e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 10 WHLDTIAVHGGYRPDpTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALA 89
Cdd:PRK06702 5 WGKGTICVQGGYTPK-NGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 90 SGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPR-EPDSFAALIDARTKAIFVESVGNPLGNI 168
Cdd:PRK06702 84 SGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 169 TDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEHaeRFRRLNEPD 248
Cdd:PRK06702 164 LNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNG--KYPELVEPD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 249 VSYHGVVYTEAFGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGL 328
Cdd:PRK06702 242 PSYHGVSYVQNFGAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 329 PEHRDHALAQRYLSGRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREET 408
Cdd:PRK06702 322 DSNENYSLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDL 401
|
410 420
....*....|....*....|.
gi 817518611 409 VRLSIGIEHLDDLLADLAQAL 429
Cdd:PRK06702 402 IRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
7-431 |
5.97e-123 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 362.40 E-value: 5.97e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 7 PADWHLDTIAVHGGYRPDPTTRAAAvPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGAL 86
Cdd:PRK08133 2 DDSLGFDTLAVRAGQLRSPFGEHSE-ALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 87 ALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLG 166
Cdd:PRK08133 81 ATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 167 NITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFrwaehaerfrrlne 246
Cdd:PRK08133 161 ELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKEL-------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 247 pdvsyhgvvYTEAFGEaayigrarvvpLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYS 326
Cdd:PRK08133 227 ---------MEEVFGF-----------LRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 327 GLPEHRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVRE 406
Cdd:PRK08133 287 GLPSHPQHELAKRQQKGGG-AIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITE 365
|
410 420
....*....|....*....|....*
gi 817518611 407 ETVRLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK08133 366 GLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
14-431 |
2.21e-122 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 361.43 E-value: 2.21e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 14 TIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQA 93
Cdd:PRK07503 12 TRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 94 AVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAA 173
Cdd:PRK07503 92 AITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 174 LAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfrrlnepdvsyhg 253
Cdd:PRK07503 172 VAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVV-------------------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 254 vvyteafGEAAYIGRARVVPLRN-TGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHR 332
Cdd:PRK07503 226 -------GGKALADRIRLEGLKDmTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 333 DHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLS 412
Cdd:PRK07503 299 QHALAQRQMALPG-GMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLS 377
|
410
....*....|....*....
gi 817518611 413 IGIEHLDDLLADLAQALEA 431
Cdd:PRK07503 378 VGLEDVADILADLAQALDA 396
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
13-429 |
1.96e-120 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 355.69 E-value: 1.96e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 13 DTIAVHGGYRPDPTtRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQ 92
Cdd:TIGR01325 1 ATLAVRGGMLRSGF-EETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 93 AAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIA 172
Cdd:TIGR01325 80 AAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 173 ALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGrfrwaehaerfrrlnepdvsyh 252
Cdd:TIGR01325 160 AVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSE---------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 253 gvvyteafgeaAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHR 332
Cdd:TIGR01325 218 -----------EYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 333 DHALAQRYLSGRGPgILTFGVrDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLS 412
Cdd:TIGR01325 287 QHELAKRQMSGGGT-VVTFDL-DCRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLS 364
|
410
....*....|....*..
gi 817518611 413 IGIEHLDDLLADLAQAL 429
Cdd:TIGR01325 365 VGLEDVDDLIADIDRAL 381
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
14-432 |
1.93e-117 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 348.74 E-value: 1.93e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 14 TIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQA 93
Cdd:PRK06234 11 TKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 94 AVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAA 173
Cdd:PRK06234 91 AISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 174 LAEIAHRH--GVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfrrlnepdvsy 251
Cdd:PRK06234 171 ISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV------------------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 252 hgvvyteafGEAAYIGRARVVPLRN-TGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPE 330
Cdd:PRK06234 227 ---------GKEEFINQVKLFGIKDmTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLES 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 331 HRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:PRK06234 298 FEYYELAKKQMSLPG-AMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVR 376
|
410 420
....*....|....*....|..
gi 817518611 411 LSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK06234 377 LSVGLEDVDDIIADLKQALDLI 398
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
9-432 |
5.29e-115 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 342.25 E-value: 5.29e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 9 DWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALAL 88
Cdd:TIGR01328 1 RMTFATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 89 ASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNI 168
Cdd:TIGR01328 81 SSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 169 TDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfrrlnepd 248
Cdd:TIGR01328 161 IDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLIC--------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 249 vsyhgvvyteafGEAAYIGRARVVPLRN-TGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSG 327
Cdd:TIGR01328 220 ------------GKAELLQQIRMVGIKDmTGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 328 LPEHRDHALAQRYLSgRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREE 407
Cdd:TIGR01328 288 FEDHPGHDIAAKQMR-MGGGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDG 366
|
410 420
....*....|....*....|....*
gi 817518611 408 TVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:TIGR01328 367 MIRLSVGLEDADDLIADLKQALDAL 391
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
7-431 |
7.86e-114 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 338.93 E-value: 7.86e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 7 PADWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAfddtQHGadlfdlkvPGNI-----YTRIMNPTQDVLEQRLALLEG 81
Cdd:PRK07811 8 HANQGFATRAIHAGYEPDPATGAVNPPIYASSTFA----QDG--------VGGLrggyeYARTGNPTRTALEEQLAALEG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 82 GVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESV 161
Cdd:PRK07811 76 GAYGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 162 GNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGrfrwAEHAERF 241
Cdd:PRK07811 156 TNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTND----EELDEAF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 242 rrlnepdvsyhgvvyteAFGEAAyigrarvvplrnTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVE 321
Cdd:PRK07811 232 -----------------AFLQNG------------AGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 322 WVDYSGLPEHRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAk 401
Cdd:PRK07811 283 TVLYPGLPSHPGHEVAARQMRGFG-GMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLE- 360
|
410 420 430
....*....|....*....|....*....|
gi 817518611 402 agVREETVRLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK07811 361 --VPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
2-432 |
7.37e-101 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 306.30 E-value: 7.37e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 2 TTAREPADWHLDTIAVHGGyrpdpTTRA----AAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLA 77
Cdd:PRK07504 1 MTTEMARKWRPATRLVHSG-----TLRSqfgeTSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMC 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 78 LLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIF 157
Cdd:PRK07504 76 ALEGAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 158 VESVGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFrWAEH 237
Cdd:PRK07504 156 LESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAW-IEEH 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 238 AERFrrlnepdvsyhgvvyteafgeaayigrarvvpLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGH 317
Cdd:PRK07504 235 LQDY--------------------------------FRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGH 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 318 GKVEWVDYSGLPEHRDHALAQRYLSGrGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPE 397
Cdd:PRK07504 283 PKVARVIYPGRADHPQADIIAKQMTG-GSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPE 361
|
410 420 430
....*....|....*....|....*....|....*
gi 817518611 398 ELAKAGVREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK07504 362 ARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
1-429 |
2.29e-99 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 302.42 E-value: 2.29e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 1 MTTAREPADWHLDTIAVHGGYRPDPTTRAAAvPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLE 80
Cdd:PRK07810 5 RTPKALPDGVSQATIGVRGGLLRSGFEETAE-ALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 81 GGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVES 160
Cdd:PRK07810 84 GAEACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFET 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 161 VGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaer 240
Cdd:PRK07810 164 PSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAIL------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 241 frrlnepdvsyhgvvyteafGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKV 320
Cdd:PRK07810 231 --------------------GDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 321 EWVDYSGLPEHRDHALAQRYLSGRGPgILTFGVR-DGRAGGAR---FQDALKLFTRLVNIGDAKSLATHPASTTHRQLSP 396
Cdd:PRK07810 291 RWVRYPFLPSHPQYDLAKRQMSGGGT-VVTFELDaPEDAAKKRafeVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGP 369
|
410 420 430
....*....|....*....|....*....|...
gi 817518611 397 EELAKAGVREETVRLSIGIEHLDDLLADLAQAL 429
Cdd:PRK07810 370 EGRAAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
9-432 |
1.96e-98 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 299.45 E-value: 1.96e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 9 DWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALAL 88
Cdd:PRK06767 3 KKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 89 ASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNI 168
Cdd:PRK06767 83 GSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 169 TDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfrrlnepd 248
Cdd:PRK06767 163 IDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTI--------------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 249 vsyhgvvyteafGEAAYIGRARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSgl 328
Cdd:PRK06767 222 ------------CKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYP-- 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 329 pehrDHALAQRYLSgRGPGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREET 408
Cdd:PRK06767 288 ----EGELASRQMK-RGGGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNL 362
|
410 420
....*....|....*....|....
gi 817518611 409 VRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK06767 363 IRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
33-432 |
7.18e-97 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 295.83 E-value: 7.18e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 33 PIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAEAGDNLVSS 112
Cdd:PRK05939 13 PIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 113 STLYGGTyNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDNTVP 192
Cdd:PRK05939 93 QFLFGNT-NSLFGTLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 193 SPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFRWAEHAERFRRLNEPDVSYHGvvyteafgeaayIGRARVV 272
Cdd:PRK05939 172 SPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWSAYPNIFPAYRKGDPQQWG------------LTQIRKK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 273 PLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHRDHALAQRYLSGRGpGILTFG 352
Cdd:PRK05939 240 GLRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYG-GLLSFE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 353 VRDGrAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK05939 319 LADG-IDCFDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
14-432 |
2.53e-92 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 283.88 E-value: 2.53e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 14 TIAVHGGYRPDPTtRAAAVPIYQTAAFAFDDTQHGADL-FDLKvpgniYTRIMNPTQDVLEQRLALLEGGVGALALASGQ 92
Cdd:PRK08574 5 TDAVRGYRGSDPY-GSLQPPIYLTALFRQEGEAYPSDRgFDLK-----YSREENPTLRPLEEALAKLEGGVDALAFNSGM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 93 AAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAhTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIA 172
Cdd:PRK08574 79 AAISTLFFSLLKAGDRVVLPMEAYGTTLRLLK-SLEKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 173 ALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRfrwaehaerfrrlnepdvsyh 252
Cdd:PRK08574 158 EVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSG--------------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 253 gvvyteAFGEAAYIGRARVvplrntGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHR 332
Cdd:PRK08574 217 ------EFLEELWEWRRRL------GTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDP 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 333 DHALAQRyLSGRG--PGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:PRK08574 285 YHGVAKR-LFGKDlyGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVR 363
|
410 420
....*....|....*....|..
gi 817518611 411 LSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK08574 364 LSVGLEDVEDLIEDLDQALGSI 385
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
11-432 |
3.12e-91 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 281.63 E-value: 3.12e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 11 HLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALAS 90
Cdd:PRK08249 8 GVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFST 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 91 GQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITD 170
Cdd:PRK08249 88 GMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 171 IAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFrwAEHAERFRRLNepdvs 250
Cdd:PRK08249 168 IERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKEL--MEQVYHYREIN----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 251 yhgvvyteafgeaayigrarvvplrntGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPE 330
Cdd:PRK08249 241 ---------------------------GATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLET 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 331 HRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:PRK08249 294 HPNHEIAKAQMRGFG-GILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVR 372
|
410 420
....*....|....*....|..
gi 817518611 411 LSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK08249 373 ISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
11-432 |
6.33e-90 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 276.97 E-value: 6.33e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 11 HLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAfddtQHGADlfdlKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALAS 90
Cdd:PRK08247 4 TIETKLAQIGNRSDERTGTVNPPVYFSTAYR----HEGIG----ESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 91 GQAAVTyAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITD 170
Cdd:PRK08247 76 GMAAIQ-LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 171 IAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRfrwaEHAERFrrlnepdvs 250
Cdd:PRK08247 155 IAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQ----ELCERL--------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 251 yhgvvyteafgeaAYIGRArvvplrnTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYsglpe 330
Cdd:PRK08247 222 -------------AYYQNA-------AGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLY----- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 331 hrdhalaqrylSGRGpGILTFGVRDgRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:PRK08247 277 -----------PGRG-GMLSFRLQD-EEWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLR 343
|
410 420
....*....|....*....|..
gi 817518611 411 LSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK08247 344 FSVGIENVEDLIADLKQAFKQV 365
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
11-432 |
1.78e-88 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 275.40 E-value: 1.78e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 11 HLDTIAVHGGYrpDPTTRAAAV--PIYQTAAFAFDDTQHGADLFDL----KVP------GNIYTRIMNPTQDVLEQRLAL 78
Cdd:PRK07049 17 HPETQMLNYGY--DPELSEGAVkpPVFLTSTFVFRSAEDGRDFFDYvsgrKEPpagegaGLVYSRFNHPNSEIVEDRLAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 79 LEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTR-FADPREPDSFAALIDA-----R 152
Cdd:PRK07049 95 YEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVgFADGLSEAAIGAAAEAaaakgR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 153 TKAIFVESVGNPLGNITDIAALAEIA----HRHG-VPLIV-DNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAI 226
Cdd:PRK07049 175 VSLILIETPANPTNSLVDVAAVRRVAdaieARQGhRPIIAcDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 227 VdsgrfrwaehaerfrrlnepdvsyhgvvyteafGEAAYIGRARvvPLRNT-GAAISPFNAFLILQGIETLGLRIDRISA 305
Cdd:PRK07049 255 L---------------------------------GRKALIRQVR--ALRSAiGTQLDPHSCWMLGRSLETLVLRMERANR 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 306 NALGVARFLQGHGKVEWVDYsgLPEHRDHALAQRYLSGR--GPG-ILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSL 382
Cdd:PRK07049 300 NARAVAEFLRDHPKVEKLHY--LPFLDPDSAYGAVYKRQctGAGsTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESL 377
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 817518611 383 ATHPASTTHRQLSPEELAKAGVREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK07049 378 ASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
14-430 |
9.27e-87 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 269.29 E-value: 9.27e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 14 TIAVHGGYRPDPTTRAAAVPIYQTAAFafddTQHGADlfdlKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQA 93
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVSTY----KQEAVG----KHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 94 AVTyAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAA 173
Cdd:PRK07671 77 AIT-AVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 174 LAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIvdsgrfrwaehaerfrrlnepdvsyhg 253
Cdd:PRK07671 156 ISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLV--------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 254 VVYTEAFGEAAYIgrarvvpLRN-TGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHR 332
Cdd:PRK07671 209 VVNSPELAEDLHF-------VQNsTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 333 DHALAQRYLSGRGpGILTFGVrdGRAGGA-RFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRL 411
Cdd:PRK07671 282 NHELAKEQANGFG-GMISFDV--GSEETAnKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRI 358
|
410
....*....|....*....
gi 817518611 412 SIGIEHLDDLLADLAQALE 430
Cdd:PRK07671 359 SVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
11-432 |
1.11e-83 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 261.37 E-value: 1.11e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 11 HLDTIAVHGGYRPDPTTRAAAVPIYQTAAFafddTQHGADlfdlKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALAS 90
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVPIYQTSTY----RQDAIG----RPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFAS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 91 GQAAVtYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITD 170
Cdd:PRK06176 74 GLAGI-HAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 171 IAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDsgrfrwaehaerfrrlNEPDVS 250
Cdd:PRK06176 153 LAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTT----------------NNEALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 251 yhgvvyteafGEAAYIGRArvvplrnTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPE 330
Cdd:PRK06176 217 ----------QEIAFFQNA-------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPT 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 331 HRDHALAQRYLSGRGpGILTFGVRDGRAGGArFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:PRK06176 280 HPNHELAKKQMRGFS-GMLSFTLKNDSEAVA-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVR 357
|
410 420
....*....|....*....|..
gi 817518611 411 LSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK06176 358 LSVGIEHEQDLLEDLEQAFAKI 379
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
12-431 |
3.15e-83 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 260.15 E-value: 3.15e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 12 LDTIAVHGGYRPDPTTrAAAVPIYQTAAFAFDDTQHGADlFDlkvpgniYTRIMNPTQDVLEQRLALLEGGVGALALASG 91
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYD-ASSMPIYQTATFKQPLAIENGP-YD-------YTRSGNPTRTALESLLAKLDKADRAFAFSSG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 92 QAAVTyAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDI 171
Cdd:TIGR01329 72 MAALD-VITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 172 AALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIvdsgrfrwaehaerfrrlnepdvsy 251
Cdd:TIGR01329 151 RKISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVL------------------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 252 hgVVYTEAFGEAAYIgrarvvpLRN-TGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPE 330
Cdd:TIGR01329 206 --AVKGEEIAKKVYF-------LQNsTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPS 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 331 HRDHALAQRYLSGRGpGILTFGVRDgRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVR 410
Cdd:TIGR01329 277 HPGFHLHFSQAKGAG-SVLSFETGS-VALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVR 354
|
410 420
....*....|....*....|.
gi 817518611 411 LSIGIEHLDDLLADLAQALEA 431
Cdd:TIGR01329 355 LSVGIEDVDDLISDLDIAFVT 375
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
9-432 |
4.54e-80 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 252.38 E-value: 4.54e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 9 DWHLDTIAVHGGYRPDPTTRAAAVPIYQTAAF-AFD-DTQHGADlfdlkvpgniYTRIMNPTQDVLEQRLALLEGGVGAL 86
Cdd:PRK08064 4 SYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFhQFDfDTFGKYD----------YSRSGNPTREALEDIIAELEGGTKGF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 87 ALASGQAAVTYAILTIAEaGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLG 166
Cdd:PRK08064 74 AFASGMAAISTAFLLLSK-GDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 167 NITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIvdsgrfrwaehaerfrrlne 246
Cdd:PRK08064 153 KVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLA-------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 247 pdvsyhgVVYTEAFGEAAYIgrarvvpLRN-TGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDY 325
Cdd:PRK08064 213 -------VVKDEELAQKLYF-------LQNsFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYY 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 326 SGLPEHRDHALAQRYLSGRGpGILTFGVRDGRAgGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVR 405
Cdd:PRK08064 279 PGLQTHLGFDIQQSQATSAG-AVLSFTLQSEEA-VRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGIT 356
|
410 420
....*....|....*....|....*..
gi 817518611 406 EETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK08064 357 DGLLRLSVGLENVDDLIADFEQALSYV 383
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
24-429 |
2.23e-79 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 250.13 E-value: 2.23e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 24 DPTTRAAAVPIYQTAAFAFDdtqhGADLFDlkvpgniYTRIMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIA 103
Cdd:PRK06460 13 DEATGAITTPIYQTTAYHYP----EGEKYR-------YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 104 EAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGV 183
Cdd:PRK06460 82 KPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 184 PLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFrwaehaerfrrLNEPDVSYhgvvyteafgea 263
Cdd:PRK06460 162 ILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKL-----------LNVIDQMR------------ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 264 ayigrarvvplRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHRDHALAQRYLSG 343
Cdd:PRK06460 219 -----------RTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 344 RGpGILTFGVRDGraggarFQDALKLFTRLVNIGDAKSLA------THPASTTHRQLSPEELAKAGVREETVRLSIGIEH 417
Cdd:PRK06460 288 FG-GVLSFEVNGG------QESALKVMKSLKLIIPAQTLGgvnsviSHPATMSHRTLSLEERKIVGITDSLLRLSVGIED 360
|
410
....*....|..
gi 817518611 418 LDDLLADLAQAL 429
Cdd:PRK06460 361 VNDLIEDLDRAL 372
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
11-430 |
1.42e-73 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 236.04 E-value: 1.42e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 11 HLDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADlFDlkvpgniYTRIMNPTQDVLEQRLALLEGGVGALALAS 90
Cdd:PRK08776 12 SAATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQ-YD-------YTRSGNPTRDLLGEALAELEGGAGGVITAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 91 GQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLaHTLPQYG----IGTRFADPRepdSFAALIDARTKAIFVESVGNPLG 166
Cdd:PRK08776 84 GMGAINLVLNALLQPGDTLVVPHDAYGGSWRLF-NALAKKGhfalITADLTDPR---SLADALAQSPKLVLIETPSNPLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 167 NITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwAEHAERFRRLne 246
Cdd:PRK08776 160 RITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVV-------ARDAELHQQL-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 247 pdvsyhgVVYTEAFGEaayigrarvvplrnTGaaiSPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYS 326
Cdd:PRK08776 231 -------VWWANALGL--------------TG---SPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 327 GLPEHRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVRE 406
Cdd:PRK08776 287 GLASHPGHALAARQQKGFG-AMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISD 365
|
410 420
....*....|....*....|....
gi 817518611 407 ETVRLSIGIEHLDDLLADLAQALE 430
Cdd:PRK08776 366 GLLRLSVGIESAEDLLIDLRAGLA 389
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
1-429 |
2.24e-71 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 232.23 E-value: 2.24e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 1 MTTAREPAdwhLDTIAVHGGYRPDPTTrAAAVPIYQTAAFAFDD-TQHGAdlFDlkvpgniYTRIMNPTQDVLEQRLALL 79
Cdd:PLN02509 79 MNIKEEAS---VSTLLVNLDNKFDPFD-AMSTPLYQTATFKQPSaIENGP--YD-------YTRSGNPTRDALESLLAKL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 80 EGGVGALALASGQAAVTyAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVE 159
Cdd:PLN02509 146 DKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 160 SVGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGrfrwaehaE 239
Cdd:PLN02509 225 SPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG--------E 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 240 RFRRlnepDVSYhgvvyteafgeaayigrarvvpLRNT-GAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHG 318
Cdd:PLN02509 297 KLAK----EVYF----------------------LQNSeGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHP 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 319 KVEWVDYSGLPEHRDHALaqRYLSGRGPG-ILTFgVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLsPE 397
Cdd:PLN02509 351 RVKKVYYAGLPDHPGHHL--HFSQAKGAGsVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASI-PA 426
|
410 420 430
....*....|....*....|....*....|...
gi 817518611 398 ELAKA-GVREETVRLSIGIEHLDDLLADLAQAL 429
Cdd:PLN02509 427 EVREArGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
14-432 |
3.88e-69 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 224.00 E-value: 3.88e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 14 TIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGAdlfdlkvpGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQA 93
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPR--------AHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 94 AVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPLGNITDIAA 173
Cdd:PRK08045 79 AIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 174 LAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfrrLNEPDVSyhg 253
Cdd:PRK08045 159 ICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI----------------AKDPDVV--- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 254 vvyTEAFGEAAYIGRarvvplrnTGAAispFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHRD 333
Cdd:PRK08045 220 ---TELAWWANNIGV--------TGGA---FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 334 HALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLSI 413
Cdd:PRK08045 286 HEIAARQQKGFG-AMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
|
410
....*....|....*....
gi 817518611 414 GIEHLDDLLADLAQALEAV 432
Cdd:PRK08045 365 GIEDGEDLIADLENGFRAA 383
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
3-430 |
1.20e-68 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 222.85 E-value: 1.20e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 3 TAREPAdwhldTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQhgadlfdlKVPGNIYTRIMNPTQDVLEQRLALLEGG 82
Cdd:PRK08861 2 STRKPA-----TIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFG--------EVPKYDYTRSGNPNRGLLEQTLSELESG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 83 VGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVG 162
Cdd:PRK08861 69 KGAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 163 NPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDsgrfRWAEHAErfr 242
Cdd:PRK08861 149 NPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLIT----KTKEHAE--- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 243 rlnepdvsyhgvvyteafgEAAYIGRArvvplrnTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEW 322
Cdd:PRK08861 222 -------------------ELAWWGNC-------IGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGT 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 323 VDYSGLPEHRDHALAQRYLSGRGpGILTFGVRDGRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKA 402
Cdd:PRK08861 276 IYHPSLPEHPGHEIAKKQQSGFG-SMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEA 354
|
410 420
....*....|....*....|....*...
gi 817518611 403 GVREETVRLSIGIEHLDDLLADLAQALE 430
Cdd:PRK08861 355 GVSQQLLRLSVGLEDAQDLIADLDQAFA 382
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
12-431 |
1.79e-68 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 222.08 E-value: 1.79e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 12 LDTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASG 91
Cdd:PRK06434 9 FNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 92 QAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAalIDART-KAIFVESVGNPLGNITD 170
Cdd:PRK06434 89 MGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 171 IAALAEIAHRHGVplIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIvdsgrfrwaehaerfrrlnepdvs 250
Cdd:PRK06434 167 IKNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVA------------------------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 251 yhGVVYTEAFGeaayigraRVVPLRNT-GAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLp 329
Cdd:PRK06434 221 --GTNNKSIFN--------NLVERRKTlGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 330 ehrdhALAQRYLSGRGpGILTFGVRdgraggaRFQDALKLFTRL------VNIGDAKSLATHPASTTHRQLSPEELAKAG 403
Cdd:PRK06434 290 -----EIGKKVLRGFG-GMLSFELR-------SMEDVHKFIRNLeipmvaASLGGVESLITLPVETSHSSLSPEERERLG 356
|
410 420
....*....|....*....|....*...
gi 817518611 404 VREETVRLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK06434 357 ISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
29-431 |
8.71e-68 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 220.72 E-value: 8.71e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 29 AAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAEAGDN 108
Cdd:PRK05968 25 AVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSFVEPGDR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 109 LVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDArTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD 188
Cdd:PRK05968 105 IVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALPG-AKLLYLESPTSWVFELQDVAALAALAKRHGVVTMID 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 189 NTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfrrlnepdvsyhgvvyteafGEAAYIGR 268
Cdd:PRK05968 184 NSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA---------------------------------GSKEHIAR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 269 ARVVPLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEWVDYSGLPEHrdhalAQRYLSGRGpGI 348
Cdd:PRK05968 231 INAEAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANH-----PPAGLSGTS-GL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 349 LTFGVRDGrAGGARFQDALKLFTRLVNIGDAKSLAThPASTTHRQLS-PEELAKAGVREETVRLSIGIEHLDDLLADLAQ 427
Cdd:PRK05968 305 FSFIFREG-IDVRAFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAqPNSAARFGVSPRSVRLHVGLEGTEALWADLEQ 382
|
....
gi 817518611 428 ALEA 431
Cdd:PRK05968 383 ALAA 386
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
9-431 |
2.20e-62 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 205.82 E-value: 2.20e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 9 DWHLDTIAVHGGYRPDPTTRAAAVPI-----YQTAAFAfddtqhgadlfdlKVPGNIYTRIMNPTQDVLEQRLALLEGGV 83
Cdd:PRK07269 4 DLHINTILAQAGIKSDEATGALVTPLhfsttYQHPEFG-------------QSTGFDYTRTKNPTRAKLEETLAAIESAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 84 GALALASGQAAVTYAiLTIAEAGDNLVSSSTLYGGTYNLLAHtlpQYGIGT-RFADPREPDSFAALIDARTKAIFVESVG 162
Cdd:PRK07269 71 YALATSSGMSAIVLA-FSVFPVGSKVVAVRDLYGGSFRWFNQ---QEKEGRfHFTYANTEEELIAAIEEDTDIVYIETPT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 163 NPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVdsgrfrwaehaerfr 242
Cdd:PRK07269 147 NPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVV--------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 243 rLNEPDVsYHGVVYTeafgeaayigrarvvpLRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEW 322
Cdd:PRK07269 212 -TNDLEL-YEKLFYN----------------LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKE 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 323 VDYSGLpehrdhalaqrylsgrgPGILTFGVRDgRAGGARFQDALKLFTRLVNIGDAKSLATHPASTTHRQLSPEELAKA 402
Cdd:PRK07269 274 VLYTGK-----------------GGMISFKVAD-ETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSY 335
|
410 420
....*....|....*....|....*....
gi 817518611 403 GVREETVRLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK07269 336 GLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
61-432 |
1.90e-55 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 187.51 E-value: 1.90e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 61 YTRIMNPTQDVLEQRLALLEGGvGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFAdPR 140
Cdd:PRK07582 45 YGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREA-PT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 141 EPDSFAALIDARTkaIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGT 220
Cdd:PRK07582 123 AGMAEAALAGADL--VLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSD 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 221 AIGGAIVDsgrfRWAEHAERFRrlnepdvsyhgvvyteafgeaayigRARvvplRNTGAAISPFNAFLILQGIETLGLRI 300
Cdd:PRK07582 201 LLLGYVAG----RDPELMAAVE-------------------------RWR----LLAGAIPGPFEAWLAHRSLGTLGLRF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 301 DRISANALGVARFLQGHGKVEWVDYSGLPEHRDHALAQRYLSgRGPGILTFGVRDgRAGGARFQDALKLFTRLVNIGDAK 380
Cdd:PRK07582 248 ARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMR-RFGGLVSFELAD-AAAAERFVAASRLVVAATSFGGVH 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 817518611 381 SLAthpastthrqlspEELAKAG--VREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK07582 326 TSA-------------DRRARWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-432 |
8.75e-54 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 184.16 E-value: 8.75e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 1 MTTAREPADWHldTIAVHGGYRPDPTTRAAAVPIYQTAAFAFDDTQHGADLFDLKVPGNIYTRIMNPTQDVLEQRLALLE 80
Cdd:PRK07050 1 MTASTPKRALQ--TRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 81 GGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVES 160
Cdd:PRK07050 79 GGRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 161 VGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRfrwAEHAEr 240
Cdd:PRK07050 159 PGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADA---ELHAK- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 241 frrlnepdvsyhgvvyteafgeaayIGRARvvplRNTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKV 320
Cdd:PRK07050 235 -------------------------LKLAR----MRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEI 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 321 EWVDYSGLPEHRDHALAQRYLSGRGpGILTFgVRDGRAGGA---RFQDALKLFTRLVNIGDAKSLAThPASTTHrqLSPE 397
Cdd:PRK07050 286 ATVLHPALPDCPGHAFWMRDFTGAG-GLFSV-VFDERYSPAqvdAFVEALELFAIGWSWGGACSLAM-PYDVAS--MRTA 360
|
410 420 430
....*....|....*....|....*....|....*
gi 817518611 398 ELAKAGvreETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:PRK07050 361 KWPHRG---TLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
60-432 |
9.76e-53 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 181.89 E-value: 9.76e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 60 IYTRIMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQ-YGIGTRFAD 138
Cdd:PLN02242 69 IYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRkCNITTTFVD 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 139 PREPDSF-AALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDNTVpSPYLLRPFEHGADIVVHSLTKYLGG 217
Cdd:PLN02242 149 ITDLEAVkKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVVHSISKFISG 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 218 HGTAIGGAIVDSgrfrwaehAERFRRLNEPdvsYHGvvyteafgeaayigrarvvPLRNTGAAISPFNAFLILQGIETLG 297
Cdd:PLN02242 228 GADIIAGAVCGP--------AELVNSMMDL---HHG-------------------ALMLLGPTMNPKVAFELSERLPHLS 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 298 LRIDRISANALGVARFLQGHGKVewVDYSGLPEHRDHALAQRyLSGRGPGiltFG-------VRDGRAGgaRFQDALKLF 370
Cdd:PLN02242 278 LRMKEHCRRAMEYAKRMKELGLK--VIYPGLEDHPQHALLKS-MANKGYG---FGgllcldmDTEERAN--RLMRYLQNS 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 817518611 371 TRL----VNIGDAKSLATHPASTTHRQLSPEELAKAGVREETVRLSIGIE-HLDDLLADLAQALEAV 432
Cdd:PLN02242 350 TQFgfmaVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGYTgTLEQRWSQFEKALSAM 416
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
3-432 |
8.18e-52 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 178.53 E-value: 8.18e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 3 TAREPADWhldtiavhGGYRPDPTTRAAAVPIYQTAAFAFDDTQHgadlfdlkvpgnIYTRIMNPTQDVLEQRLALLEGG 82
Cdd:TIGR01324 6 SGRQPRFS--------QGSVNPPLQRASTVLFDSHAAQRRAKGEL------------TYGRRGTLTHFALQDAMCELEGG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 83 VGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVG 162
Cdd:TIGR01324 66 AGCYLYPSGLAAVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 163 NPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRfRWAEHAERFR 242
Cdd:TIGR01324 146 SITFEIQDIPAIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANAR-TWDQLREHSY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 243 RLnepdvsyhgvvyteafgeaayigrarvvplrntGAAISPFNAFLILQGIETLGLRIDRISANALGVARFLQGHGKVEW 322
Cdd:TIGR01324 225 LM---------------------------------GQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVAR 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 323 VDYSGLPEHRDHALAQRYLSGrGPGILTFGV-RDGRAGGARFQDALKLFTRLVNIGDAKSLAThpasTTHRQLSPEELAK 401
Cdd:TIGR01324 272 VLHPALPSCPGHEFWKRDFSG-SSGLFSFVLqRLTQKQVHAFLDHLQLFGLGYSWGGYESLAL----CNQPELGHRPNIK 346
|
410 420 430
....*....|....*....|....*....|.
gi 817518611 402 AGVREETVRLSIGIEHLDDLLADLAQALEAV 432
Cdd:TIGR01324 347 RNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
67-431 |
2.20e-50 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 175.00 E-value: 2.20e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 67 PTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFA 146
Cdd:PRK05967 64 PTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 147 ALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAI 226
Cdd:PRK05967 144 KLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 227 VDSgrfrwAEHAERFrrlnepdvsyhgvvyTEAFGeaayigrarvvplrNTGAAISPFNAFLILQGIETLGLRIDRISAN 306
Cdd:PRK05967 224 SAN-----EKCWPQL---------------LEAHG--------------TLGLCAGPDDTYQILRGLRTMGIRLEHHRKS 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 307 ALGVARFLQGHGKVEWVDYSGLPEHRDHALAQRYLSGrGPGILTF----GVRDGRAGGARFQDALKLFTRLVNIGDAKSL 382
Cdd:PRK05967 270 ALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSG-ASGIFSFvlaaGPEKGKAKAHAFLDALEIFGLGYSWGGYESL 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 817518611 383 ATHPastthrQLSPEELAKAGVREETVRLSIGIEHLDDLLADLAQALEA 431
Cdd:PRK05967 349 ALHV------KLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGFAA 391
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
61-430 |
5.56e-42 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 152.58 E-value: 5.56e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 61 YTRIMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPR 140
Cdd:PRK09028 55 YGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPM 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 141 EPDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGT 220
Cdd:PRK09028 135 IGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSD 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 221 AIGGAIVDSGRfrwaeHAERFRrlnepdvsyhgvvyteafgEAAYIgrarvvplrnTGAAISPFNAFLILQGIETLGLRI 300
Cdd:PRK09028 215 VMLGTATANEK-----HWDQLR-------------------EHSYL----------MGQCTSPDDVYLAMRGLRTLGVRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 301 DRISANALGVARFLQGHGKVEWVDYSGLPEHRDHALAQRYLSGrGPGILTFGVRDG--RAGGArFQDALKLFTRLVNIGD 378
Cdd:PRK09028 261 AQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSG-SNGLFSFVLKQGdpKAVTA-LVEGMQHFKMGFSWGG 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 817518611 379 AKSLA-THPASTTHRQLSPEELAKAgvreeTVRLSIGIEHLDDLLADLAQALE 430
Cdd:PRK09028 339 FESLIlGVFGINKLRTATNWDFSKP-----LIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
8-430 |
1.61e-38 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 143.31 E-value: 1.61e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 8 ADWHLDTIAVHGGyRPDPTTRAAAVPIYQTAA-FAFDDTQH---------GADLFdlkvpgniYTRIMNPTQDVLEQRLA 77
Cdd:PRK08114 2 TDKKLDTQLVNAG-RSKKYTQGSVNSVIQRASsLVFDSVEAkkhatrnraNGELF--------YGRRGTLTHFSLQEAMC 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 78 LLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREPDSFAALIDARTKAIF 157
Cdd:PRK08114 73 ELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 158 VESVGNPLGNITDIAALAEiAHRHGVPLIV---DNTVPSPYLLRPFEHGADIVVHSLTKYLGGHGTAIGGAIVDSGRFrW 234
Cdd:PRK08114 153 LESPGSITMEVHDVPAIVA-AVRSVNPDAVimiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARC-W 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 235 aehaERFRrlnepdvsyhgvvyteafgEAAYIgrarvvplrnTGAAISPFNAFLILQGIETLGLRIDRISANALGVARFL 314
Cdd:PRK08114 231 ----EQLR-------------------ENSYL----------MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 315 QGHGKVEWVDYSGLPEHRDHALAQRYLSGRGpGILTFGVRD--GRAGGARFQDALKLFTRLVNIGDAKSLATHPastthr 392
Cdd:PRK08114 278 AEHPEVARVNHPALPGCKGHEFWKRDFTGSS-GLFSFVLKKklTDEQLANYLDNFSLFSMAYSWGGFESLILAN------ 350
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 817518611 393 qlSPEELAK---AGVREET---VRLSIGIEHLDDLLADLAQALE 430
Cdd:PRK08114 351 --QPEEIAAirpAGEVDFTgtlIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
69-220 |
1.00e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 63.17 E-value: 1.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 69 QDVLEQRLA--LLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNllAHTLPQYGIGTRFADPREPD--- 143
Cdd:cd01494 2 LEELEEKLArlLQPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYW--VAAELAGAKPVPVPVDDAGYggl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 144 SFAALIDA----RTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDNT-----VPSPYLLRPFEhGADIVVHSLTKY 214
Cdd:cd01494 80 DVAILEELkakpNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsaggaSPAPGVLIPEG-GADVVTFSLHKN 158
|
....*.
gi 817518611 215 LGGHGT 220
Cdd:cd01494 159 LGGEGG 164
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
142-220 |
1.13e-08 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 56.71 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 142 PDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD--NTVPSpyllRPF---EHGADIVVHSLTKYLG 216
Cdd:cd06453 129 LEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDgaQSAGH----MPVdvqDLGCDFLAFSGHKMLG 204
|
....
gi 817518611 217 GHGT 220
Cdd:cd06453 205 PTGI 208
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
59-243 |
2.90e-08 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 55.39 E-value: 2.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 59 NIYTRImnPTQDVLEQRLALLEGG--------VGALALASG-QAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHtlpq 129
Cdd:pfam00155 33 NLYGPT--DGHPELREALAKFLGRspvlkldrEAAVVFGSGaGANIEALIFLLANPGDAILVPAPTYASYIRIARL---- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 130 YGIGTRFADPREPDSF-------AALIDARTKAIFVESVGNPLG---NITDIAALAEIAHRHGVPLIVD----NTV---P 192
Cdd:pfam00155 107 AGGEVVRYPLYDSNDFhldfdalEAALKEKPKVVLHTSPHNPTGtvaTLEELEKLLDLAKEHNILLLVDeayaGFVfgsP 186
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 817518611 193 SPYLLRPF--EHGADIVVHSLTKYLGGHGTAIGGAIVDSgrfRWAEHAERFRR 243
Cdd:pfam00155 187 DAVATRALlaEGPNLLVVGSFSKAFGLAGWRVGYILGNA---AVISQLRKLAR 236
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
89-233 |
5.13e-08 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 54.27 E-value: 5.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 89 ASGQAAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAH---TLPQYGIGTRFADPREPDSFAALIDARTKAIFVESVGNPL 165
Cdd:cd00609 66 NGAQEALSLLLRALLNPGDEVLVPDPTYPGYEAAARLagaEVVPVPLDEEGGFLLDLELLEAAKTPKTKLLYLNNPNNPT 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 166 GNITD---IAALAEIAHRHGVPLIVD----------NTVPSPYLLRPFEHGadIVVHSLTKYLGGHGTAIGGAIVDSGRF 232
Cdd:cd00609 146 GAVLSeeeLEELAELAKKHGILIISDeayaelvydgEPPPALALLDAYERV--IVLRSFSKTFGLPGLRIGYLIAPPEEL 223
|
.
gi 817518611 233 R 233
Cdd:cd00609 224 L 224
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
72-335 |
6.14e-08 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 54.08 E-value: 6.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 72 LEQRLALLEGGVGALALASGQAA--VTYAILTIAEAGDNLVSSSTlYGGTYNLLAHTlpqyGIGTRFADPRE------PD 143
Cdd:cd00616 23 FEKAFAEYLGVKYAVAVSSGTAAlhLALRALGIGPGDEVIVPSFT-FVATANAILLL----GATPVFVDIDPdtynidPE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 144 SFAALIDARTKAIFVESVGnplGNITDIAALAEIAHRHGVPLIVDN--TVPSPYLLRPfeHG--ADIVVHSL--TKYLgg 217
Cdd:cd00616 98 LIEAAITPRTKAIIPVHLY---GNPADMDAIMAIAKRHGLPVIEDAaqALGATYKGRK--VGtfGDAGAFSFhpTKNL-- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 218 hGTAIGGAIVdsgrFRWAEHAERFRRLnepdvSYHGVVYTEAFGEAAYIGrarvvplrnTGAAISPFNAFLILQGIETLG 297
Cdd:cd00616 171 -TTGEGGAVV----TNDEELAERARLL-----RNHGRDRDRFKYEHEILG---------YNYRLSEIQAAIGLAQLEKLD 231
|
250 260 270
....*....|....*....|....*....|....*...
gi 817518611 298 LRIDRISANAlgvARFLQGHGKVEWVDYSGLPEHRDHA 335
Cdd:cd00616 232 EIIARRREIA---ERYKELLADLPGIRLPDVPPGVKHS 266
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
86-190 |
9.13e-08 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 53.81 E-value: 9.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 86 LALASG-QAAVTYAILTIAEAGDNLVSSSTLYggtYNllaH--TLPQYGIGTRFADPRE-------PDSFAALIDARTKA 155
Cdd:PRK07550 93 VHITSGcNQAFWAAMVTLAGAGDEVILPLPWY---FN---HkmWLDMLGIRPVYLPCDEgpgllpdPAAAEALITPRTRA 166
|
90 100 110
....*....|....*....|....*....|....*...
gi 817518611 156 IFVESVGNPLGNITD---IAALAEIAHRHGVPLIVDNT 190
Cdd:PRK07550 167 IALVTPNNPTGVVYPpelLHELYDLARRHGIALILDET 204
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
64-242 |
1.49e-07 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 53.06 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 64 IMNPTQDVLEQRLALLEGGVGALALASGQAAVTYAILTIAE-AGDNLVSSSTLYGGTYNLLAHTlpqyGIGTRFADPrEP 142
Cdd:pfam01041 21 TTGPYVREFERAFAAYLGVKHAIAVSSGTAALHLALRALGVgPGDEVITPSFTFVATANAALRL----GAKPVFVDI-DP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 143 DSF-------AALIDARTKAIFVESVGnplGNITDIAALAEIAHRHGVPLIVD--NTVPSPYLLRPFEHGADIVVHSL-- 211
Cdd:pfam01041 96 DTYnidpeaiEAAITPRTKAIIPVHLY---GQPADMDAIRAIAARHGLPVIEDaaHALGATYQGKKVGTLGDAATFSFhp 172
|
170 180 190
....*....|....*....|....*....|..
gi 817518611 212 TKYLgghGTAIGGAIV-DSGRFrwAEHAERFR 242
Cdd:pfam01041 173 TKNL---TTGEGGAVVtNDPEL--AEKARVLR 199
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
142-188 |
5.22e-07 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 51.29 E-value: 5.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 817518611 142 PDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD 188
Cdd:COG0520 144 LEALEALLTPRTKLVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVD 190
|
|
| LdcC |
COG1982 |
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism]; |
142-235 |
1.78e-06 |
|
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];
Pssm-ID: 441585 [Multi-domain] Cd Length: 486 Bit Score: 50.11 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 142 PDSFAALIDA--RTKAIFVESvGNPLGNITDIAALAEIAHRHGVPLIVDntvpS---PYL-----LRPF--EHGADIVVH 209
Cdd:COG1982 149 PEAVEEALIEhpDAKAVLITN-PTYYGVCYDLKAIAELAHEHGIPVLVD----EahgAHFgfhpdLPRSamEAGADLVVQ 223
|
90 100 110
....*....|....*....|....*....|...
gi 817518611 210 SLTKYLGG-------HgtaIGGAIVDSGRFRWA 235
Cdd:COG1982 224 STHKTLGAltqssmlH---VKGGRVDHERVNEA 253
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
91-188 |
1.79e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 49.85 E-value: 1.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 91 GQAAVTYAILTIAEAGDNLVSSSTLYGgTYNLLA----------HTLPQYGigtrFADPrEPDSFAALIDARTKAIFVES 160
Cdd:PRK07568 97 GSEAILFAMMAICDPGDEILVPEPFYA-NYNGFAtsagvkivpvTTKIEEG----FHLP-SKEEIEKLITPKTKAILISN 170
|
90 100 110
....*....|....*....|....*....|.
gi 817518611 161 VGNPLGNI---TDIAALAEIAHRHGVPLIVD 188
Cdd:PRK07568 171 PGNPTGVVytkEELEMLAEIAKKHDLFLISD 201
|
|
| tyr_amTase_E |
TIGR01264 |
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ... |
67-188 |
2.12e-06 |
|
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273529 [Multi-domain] Cd Length: 401 Bit Score: 49.78 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 67 PTQDVLEQRLAL------LEGGVGA--LALASG-QAAVTYAILTIAEAGDN-LVSSS--TLYggtynllaHTLPQ-YGIG 133
Cdd:TIGR01264 71 PTVGALSAREAIasyyhnPDGPIEAddVVLCSGcSHAIEMCIAALANAGQNiLVPRPgfPLY--------ETLAEsMGIE 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 817518611 134 TRFADPREPDSFAA-------LIDARTKAIFVESVGNPLGNITDIAALAEI---AHRHGVPLIVD 188
Cdd:TIGR01264 143 VKLYNLLPDKSWEIdlkqlesLIDEKTAALIVNNPSNPCGSVFSRQHLEEIlavAERQCLPIIAD 207
|
|
| tyr_nico_aTase |
TIGR01265 |
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ... |
88-188 |
3.86e-06 |
|
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.
Pssm-ID: 188123 Cd Length: 403 Bit Score: 48.88 E-value: 3.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 88 LASG-QAAVTYAILTIAEAGDNLvssstlyggtynLLAH-TLPQY-------GIGTRFAD--PREP-----DSFAALIDA 151
Cdd:TIGR01265 101 LTSGcSQAIEICIEALANPGANI------------LVPRpGFPLYdtraafsGLEVRLYDllPEKDweidlDGLESLADE 168
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 817518611 152 RTKAIFVESVGNPLGNITD---IAALAEIAHRHGVPLIVD 188
Cdd:TIGR01265 169 KTVAIVVINPSNPCGSVFSrdhLQKIAEVAEKLGIPIIAD 208
|
|
| avtA |
PRK09440 |
valine--pyruvate transaminase; Provisional |
141-229 |
5.99e-06 |
|
valine--pyruvate transaminase; Provisional
Pssm-ID: 236517 Cd Length: 416 Bit Score: 48.31 E-value: 5.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 141 EPDsFAAL-IDARTKAIFVESVGNPLGN-ITD--IAALAEIAHRHGVPLIVDNT--VPSPYL----LRPFEHGADIVVHS 210
Cdd:PRK09440 168 HVD-FEHLhIDEDTGAICVSRPTNPTGNvLTDeeLEKLDALARQHNIPLLIDNAygPPFPGIifseATPLWNPNIILCMS 246
|
90
....*....|....*....
gi 817518611 211 LTKyLGGHGTAIGGAIVDS 229
Cdd:PRK09440 247 LSK-LGLPGVRCGIVIADE 264
|
|
| PRK11658 |
PRK11658 |
UDP-4-amino-4-deoxy-L-arabinose aminotransferase; |
72-253 |
8.33e-06 |
|
UDP-4-amino-4-deoxy-L-arabinose aminotransferase;
Pssm-ID: 183263 Cd Length: 379 Bit Score: 47.71 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 72 LEQRLALLEGGVGALALASGQAA--VTYAILTIAeAGDNLVSSSTLYGGTYNLLahTLpqygIGtrfADP------RE-- 141
Cdd:PRK11658 38 LEQAFCQLTGNQHAIAVSSATAGmhITLMALGIG-PGDEVITPSLTWVSTLNMI--VL----LG---ATPvmvdvdRDtl 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 142 ---PDSFAALIDARTKAIF-VESVGNPLgnitDIAALAEIAHRHGVPLIVDntvpspyllrpfehgadiVVHSL-TKY-- 214
Cdd:PRK11658 108 mvtPEAIEAAITPRTKAIIpVHYAGAPA----DLDAIRAIGERYGIPVIED------------------AAHAVgTYYkg 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 817518611 215 --LGGHGTAI-------------GGAIVDSGrfrwAEHAERFRRLNepdvsYHG 253
Cdd:PRK11658 166 rhIGARGTAIfsfhaiknitcaeGGLVVTDD----DELADRLRSLK-----FHG 210
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
86-216 |
2.10e-05 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 46.28 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 86 LALASGQAAVTYAILTIAEAGDNLV----------SSSTLYGGTynllAHTLPQYgIGTRFAdPRePDSFAALIDARTKA 155
Cdd:COG0436 94 LVTNGAKEALALALLALLNPGDEVLvpdpgypsyrAAVRLAGGK----PVPVPLD-EENGFL-PD-PEALEAAITPRTKA 166
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 817518611 156 IFVESVGNPLGNI---TDIAALAEIAHRHGVPLIVDNT--------VPSPYLLRpFEHGAD--IVVHSLTKYLG 216
Cdd:COG0436 167 IVLNSPNNPTGAVysrEELEALAELAREHDLLVISDEIyeelvydgAEHVSILS-LPGLKDrtIVINSFSKSYA 239
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
143-208 |
2.49e-05 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 46.28 E-value: 2.49e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 817518611 143 DSFAALIDARTKAIFVEsvgNP--LGNITDIAALAEIAHRHGVPLIVdntVPSPYLL----RPFEHGADIVV 208
Cdd:PRK00451 195 EALEAAVDDDTAAVVVQ---YPnfFGVIEDLEEIAEIAHAGGALFIV---GVDPVSLgllkPPGEYGADIVV 260
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
72-189 |
3.05e-05 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 45.83 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 72 LEQRLALLEGGVGALALASGqaavTYAILTIAEA-----GDN-LVSSSTlYGGTYNLLAHTlpqyGIGTRFADPrEPDSF 145
Cdd:COG0399 35 FEEEFAAYLGVKHAVAVSSG----TAALHLALRAlgigpGDEvITPAFT-FVATANAILYV----GATPVFVDI-DPDTY 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 817518611 146 -------AALIDARTKAIFVesVgNPLGNITDIAALAEIAHRHGVPLIVDN 189
Cdd:COG0399 105 nidpealEAAITPRTKAIIP--V-HLYGQPADMDAIMAIAKKHGLKVIEDA 152
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
149-217 |
1.66e-04 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 43.57 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 149 IDARTKAI------------FVESVgnplgnitDIAALAEIAHRHGVPLIVD----NTVPSPYLLRPFE--------HGA 204
Cdd:COG1921 151 ITENTAALlkvhtsnyrivgFTEEV--------SLAELAELAHEHGLPVIVDlgsgSLVDLSKYGLPHEptvqeylaAGA 222
|
90
....*....|...
gi 817518611 205 DIVVHSLTKYLGG 217
Cdd:COG1921 223 DLVTFSGDKLLGG 235
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
142-188 |
1.73e-04 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 43.58 E-value: 1.73e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 817518611 142 PDSFAALIDARTKAIFVESVGNPLGNI---TDIAALAEIAHRHGVPLIVD 188
Cdd:PRK05764 154 VEQLEAAITPKTKALILNSPSNPTGAVyspEELEAIADVAVEHDIWVLSD 203
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
99-223 |
2.46e-04 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 43.20 E-value: 2.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 99 ILTIAEAGDNLVSsstlyggtYNLLAHtlpQYGIGTRFA--DPREP---DSFAALIDARTKAIFVESVGNPLGNITDIAA 173
Cdd:PLN02855 126 ILSVAEHHSNIVP--------WQLVAQ---KTGAVLKFVglTPDEVldvEQLKELLSEKTKLVATHHVSNVLGSILPVED 194
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 817518611 174 LAEIAHRHGVPLIVD--NTVP-SPYLLRPFehGADIVVHSLTKYLGghGTAIG 223
Cdd:PLN02855 195 IVHWAHAVGAKVLVDacQSVPhMPVDVQTL--GADFLVASSHKMCG--PTGIG 243
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
141-220 |
3.29e-04 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 42.62 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 141 EPDSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD--NTVPSpyllRPF---EHGADIVVHSLTKYL 215
Cdd:pfam00266 128 DLDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDaaQAIGH----RPIdvqKLGVDFLAFSGHKLY 203
|
....*
gi 817518611 216 GGHGT 220
Cdd:pfam00266 204 GPTGI 208
|
|
| f2_encap_cargo1 |
NF041166 |
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like ... |
143-188 |
5.26e-04 |
|
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like encapsulin nanocompartments are commonly found in bacteria and archaea. Encapsulin nanocompartments, which are assembled from shell proteins, encapsulate various cargo proteins, typically peroxidases or ferritin-like proteins, to protect cells from oxidative stress caused by peroxide. Proteins of this family are cysteine desulfurases with an additional N-terminal encapsulation targeting sequence (~200 aa) that is necessary and sufficient for compartmentalization.
Pssm-ID: 469077 [Multi-domain] Cd Length: 623 Bit Score: 42.15 E-value: 5.26e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 817518611 143 DSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD 188
Cdd:NF041166 377 DEYAKLLNPRTKLVSVTQVSNALGTVTPVKEIIALAHRAGAKVLVD 422
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
67-227 |
8.27e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 41.28 E-value: 8.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 67 PTQDVLEQRLALLE----GGVGALALASGQAAVTYAILTIAEAGDNLVSSSTlyggTYNLLAHTLPQYGIGTRFADPRE- 141
Cdd:PRK06225 64 PPEGFPELRELILKdlglDDDEALITAGATESLYLVMRAFLSPGDNAVTPDP----GYLIIDNFASRFGAEVIEVPIYSe 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 142 -------PDSFAALIDARTKAIFVESVGNPLG---NITDIAALAEIAHRHGVPLIVDNT----VPSPYLLRPFEHGADIV 207
Cdd:PRK06225 140 ecnykltPELVKENMDENTRLIYLIDPLNPLGssyTEEEIKEFAEIARDNDAFLLHDCTyrdfAREHTLAAEYAPEHTVT 219
|
170 180
....*....|....*....|
gi 817518611 208 VHSLTKYLGGHGTAIgGAIV 227
Cdd:PRK06225 220 SYSFSKIFGMAGLRI-GAVV 238
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
142-208 |
8.93e-04 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 41.55 E-value: 8.93e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 817518611 142 PDSFAALIDARTKAIFVESVgNPLGNITDIAALAEIAHRHGVPLIVdNTVPSPY-LLR-PFEHGADIVV 208
Cdd:COG0403 195 LEALKALLDDDVAGVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIV-AADPLSLgLLKpPGELGADIVV 261
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
61-251 |
8.98e-04 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 41.12 E-value: 8.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 61 YTRIMNPTQDVLeQRLALLEGGVGALALASGQAAVTYAILTIAEAGDNLVSSSTlygGTY-NLLAHTLPQYGIGTRF--A 137
Cdd:cd06451 30 FLALMDEILEGL-RYVFQTENGLTFLLSGSGTGAMEAALSNLLEPGDKVLVGVN---GVFgDRWADMAERYGADVDVveK 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 138 DPREPDSFAALIDA----RTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVDnTVPS--PYLLRPFEHGADIVVHSL 211
Cdd:cd06451 106 PWGEAVSPEEIAEAleqhDIKAVTLTHNETSTGVLNPLEGIGALAKKHDALLIVD-AVSSlgGEPFRMDEWGVDVAYTGS 184
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 817518611 212 TKYLGG-HGTAIggaIVDSGRFRwaehaERFRRLNEPDVSY 251
Cdd:cd06451 185 QKALGApPGLGP---IAFSERAL-----ERIKKKTKPKGFY 217
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
84-210 |
9.81e-04 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 41.20 E-value: 9.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 84 GALALASgqaAVTYAILTIAEAGDNLVSSSTLYGGTYNLLAHTLPQYGIGTRFADPREpDSFAALIDarTKAIFVESVgN 163
Cdd:pfam02347 135 EGTAAAE---AMALAARASKKKGKKFVVDKDVHPQTLEVLKTRAKPFGIEIVEVDYTE-EGVTDLKD--VFGVLVQYP-N 207
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 817518611 164 PLGNITDIAALAEIAHRHGVPLIVDNTVPSPYLLR-PFEHGADIVVHS 210
Cdd:pfam02347 208 TDGRIEDYKELIELAHQRKSLVVVAADLLALTLLKpPGEFGADIAVGS 255
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
143-219 |
1.00e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 41.06 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 143 DSFAALIDARTKAIFVEsvgNP--LGNITD-IAALAEIAHRHGVPLIVD-NTVPSPYLLRPFEHGADIVVHSLTKYLGGH 218
Cdd:cd00613 150 EALKEEVSEEVAALMVQ---YPntLGVFEDlIKEIADIAHSAGALVYVDgDNLNLTGLKPPGEYGADIVVGNLQKTGVPH 226
|
.
gi 817518611 219 G 219
Cdd:cd00613 227 G 227
|
|
| PTZ00433 |
PTZ00433 |
tyrosine aminotransferase; Provisional |
88-188 |
1.62e-03 |
|
tyrosine aminotransferase; Provisional
Pssm-ID: 185613 Cd Length: 412 Bit Score: 40.54 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 88 LASGQA-AVTYAILTIAEAGDNLVSSSTLYGgTYNLLAHTlpqYGIGTRF--ADPREP-----DSFAALIDARTKAIFVE 159
Cdd:PTZ00433 109 LCSGVShAILMALTALCDEGDNILVPAPGFP-HYETVCKA---YGIEMRFynCRPEKDweadlDEIRRLVDDRTKALIMT 184
|
90 100 110
....*....|....*....|....*....|....*
gi 817518611 160 SVGNPLG------NITDIAALAEiaHRHgVPLIVD 188
Cdd:PTZ00433 185 NPSNPCGsnfsrkHVEDIIRLCE--ELR-LPLISD 216
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
101-243 |
2.33e-03 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 40.07 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 101 TIAEAGDNLVSSS----TLY------GGTYNLLAHT-LPQYGIgtrfadprEPDSFAALIDARTKA-------IFVESVG 162
Cdd:cd06452 78 SLCEKGDWVVVDGlahyTSYvaaeraGLNVREVPNTgHPEYHI--------TPEGYAEVIEEVKDEfgkppalALLTHVD 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 163 NPLGNITDIAALAEIAHRHGVPLIVdNTVPS----PYLLRpfEHGADIVVHSltkylgGH-GTAIGGAI-VDSGRFRWAE 236
Cdd:cd06452 150 GNYGNLHDAKKIAKVCHEYGVPLLL-NGAYTvgrmPVSGK--ELGADFIVGS------GHkSMAASAPIgVLATTEEWAD 220
|
....*..
gi 817518611 237 haERFRR 243
Cdd:cd06452 221 --IVFRT 225
|
|
| PRK09295 |
PRK09295 |
cysteine desulfurase SufS; |
143-188 |
3.85e-03 |
|
cysteine desulfurase SufS;
Pssm-ID: 181766 [Multi-domain] Cd Length: 406 Bit Score: 39.35 E-value: 3.85e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 817518611 143 DSFAALIDARTKAIFVESVGNPLGNITDIAALAEIAHRHGVPLIVD 188
Cdd:PRK09295 155 ETLPALFDERTRLLAITHVSNVLGTENPLAEMIALAHQHGAKVLVD 200
|
|
| PRK15407 |
PRK15407 |
lipopolysaccharide biosynthesis protein RfbH; Provisional |
126-189 |
3.96e-03 |
|
lipopolysaccharide biosynthesis protein RfbH; Provisional
Pssm-ID: 237960 Cd Length: 438 Bit Score: 39.48 E-value: 3.96e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 817518611 126 TLPQYGIgtrfadprEPDSFAALIDARTKAIFV-ESVGNPLgnitDIAALAEIAHRHGVPLIVDN 189
Cdd:PRK15407 141 ELPTYNI--------DASLLEAAVSPKTKAIMIaHTLGNPF----DLAAVKAFCDKHNLWLIEDN 193
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
147-217 |
4.84e-03 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 38.77 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817518611 147 ALIDAR-TKAIFVESvGNPLGNITDIAALAEIAHRHGVPLIVD----------NTVPSPYLLRpfehGADIVVHSLTKYL 215
Cdd:cd00615 148 ALIEHPdAKAAVITN-PTYYGICYNLRKIVEEAHHRGLPVLVDeahgahfrfhPILPSSAAMA----GADIVVQSTHKTL 222
|
..
gi 817518611 216 GG 217
Cdd:cd00615 223 PA 224
|
|
| |
