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Conserved domains on  [gi|817735571|ref|WP_046688317|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Serratia]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-111 1.26e-34

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 115.73  E-value: 1.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817735571   6 DVYSSKCSARDALALISGKWVMLILPALAQRPMRNGELLRRIDGISQKVLTQTLRQLERNGLLERLDLSEKnQAHVEYRL 85
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEV-PPRVEYSL 82

                         90       100
                 ....*....|....*....|....*.
gi 817735571  86 SAVACSLVETLTALDRWAEYHFPELD 111
Cdd:COG1733   83 TEKGRSLLPVLDALAEWGEEHLPEIE 108
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-111 1.26e-34

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 115.73  E-value: 1.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817735571   6 DVYSSKCSARDALALISGKWVMLILPALAQRPMRNGELLRRIDGISQKVLTQTLRQLERNGLLERLDLSEKnQAHVEYRL 85
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEV-PPRVEYSL 82

                         90       100
                 ....*....|....*....|....*.
gi 817735571  86 SAVACSLVETLTALDRWAEYHFPELD 111
Cdd:COG1733   83 TEKGRSLLPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 20-111 6.17e-22

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 82.74  E-value: 6.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817735571   20 LISGKWVMLILPALAQRPMRNGELLRRIDGISQKVLTQTLRQLERNGLLERLDLSEkNQAHVEYRLSAVACSLVETLTAL 99
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPE-VPPKVEYSLTEKGRSLEPILQEL 79

                          90
                  ....*....|..
gi 817735571  100 DRWAEYHFPELD 111
Cdd:pfam01638  80 CDWGEEYLEPED 91
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-88 1.56e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.66  E-value: 1.56e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 817735571  18 LALISGKWVMLILPALAQRPMRNGELLRRIdGISQKVLTQTLRQLERNGLLERldlsEKNQAHVEYRLSAV 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVES----RREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-86 1.43e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.88  E-value: 1.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 817735571    29 ILPALAQRPMRNGELLRRIdGISQKVLTQTLRQLERNGLLErldlSEKNQAHVEYRLS 86
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVE----SRREGKRVYYSLT 54
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-111 1.26e-34

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 115.73  E-value: 1.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817735571   6 DVYSSKCSARDALALISGKWVMLILPALAQRPMRNGELLRRIDGISQKVLTQTLRQLERNGLLERLDLSEKnQAHVEYRL 85
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEV-PPRVEYSL 82

                         90       100
                 ....*....|....*....|....*.
gi 817735571  86 SAVACSLVETLTALDRWAEYHFPELD 111
Cdd:COG1733   83 TEKGRSLLPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 20-111 6.17e-22

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 82.74  E-value: 6.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817735571   20 LISGKWVMLILPALAQRPMRNGELLRRIDGISQKVLTQTLRQLERNGLLERLDLSEkNQAHVEYRLSAVACSLVETLTAL 99
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPE-VPPKVEYSLTEKGRSLEPILQEL 79

                          90
                  ....*....|..
gi 817735571  100 DRWAEYHFPELD 111
Cdd:pfam01638  80 CDWGEEYLEPED 91
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-88 1.56e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.66  E-value: 1.56e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 817735571  18 LALISGKWVMLILPALAQRPMRNGELLRRIdGISQKVLTQTLRQLERNGLLERldlsEKNQAHVEYRLSAV 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVES----RREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-86 1.43e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.88  E-value: 1.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 817735571    29 ILPALAQRPMRNGELLRRIdGISQKVLTQTLRQLERNGLLErldlSEKNQAHVEYRLS 86
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVE----SRREGKRVYYSLT 54
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
29-87 3.45e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 34.62  E-value: 3.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 817735571  29 ILPALAQRPMRNGELLRRIdGISQKVLTQTLRQLERNGLLE-RLDLSEKNQAHVEYRLSA 87
Cdd:COG1777   22 ILALLSEEPAYVSELAREL-GVSRQAVYKHLRKLEEAGLVEsYREGREDGRARKYYRLSA 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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