NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|822526326|ref|WP_046956240|]
View 

MULTISPECIES: CPBP family intramembrane glutamic endopeptidase [Bacillus]

Protein Classification

CPBP family intramembrane glutamic endopeptidase( domain architecture ID 11441430)

CPBP (CAAX proteases and bacteriocin-processing enzymes) family intramembrane protease similar to Saccharomyces cerevisiae Rce1, a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease that belongs to the glutamate IMPs, sharing a conserved sequence motif EExxxR

EC:  3.4.-.-
Gene Ontology:  GO:0004222|GO:0016020|GO:0070007|GO:0071586
PubMed:  24291792

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 143-223 1.41e-17

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 74.83  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822526326 143 VPIFEELIVRGIILHFLQQRFPFWIAAFGSSFLFGIGHIYSTGVMFSMFIMGLFMAILCKKTKSIIPAILLHIMNNMLAF 222
Cdd:COG1266   15 APIAEELLFRGYLLGRLRRRFGPWLAILLSSLLFGLLHLPNLLGFLPAFLLGLVLGLLYLRTGSLWVPILLHALNNLLAL 94


                 .
gi 822526326 223 L 223
Cdd:COG1266   95 L 95
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 143-223 1.41e-17

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 74.83  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822526326 143 VPIFEELIVRGIILHFLQQRFPFWIAAFGSSFLFGIGHIYSTGVMFSMFIMGLFMAILCKKTKSIIPAILLHIMNNMLAF 222
Cdd:COG1266   15 APIAEELLFRGYLLGRLRRRFGPWLAILLSSLLFGLLHLPNLLGFLPAFLLGLVLGLLYLRTGSLWVPILLHALNNLLAL 94


                 .
gi 822526326 223 L 223
Cdd:COG1266   95 L 95
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 143-220 2.65e-13

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 63.34  E-value: 2.65e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 822526326  143 VPIFEELIVRGIILHFLQQRFPFWIAAFGSSFLFGIGHIYST-GVMFSMFIMGLFMAILCKKTKSIIPAILLHIMNNML 220
Cdd:pfam02517  14 APIGEELLFRGYLLPRLRRRLWPVLAILISSLLFGLAHLPNGpQLFLLAFLLGLILGYLYLRTGSLWAAILLHALNNLL 92
pepcterm_CAAX TIGR03008
CAAX prenyl protease-related protein; The CAAX prenyl protease, in eukaryotes, catalyzes three ...
 143-220 1.55e-03

CAAX prenyl protease-related protein; The CAAX prenyl protease, in eukaryotes, catalyzes three covalent modifications, including cleavage and acylation, at the C-terminus of certain proteins in a process connected to protein sorting. This family describes a bacterial protein family homologous to one domain of the CAAX-processing enzyme. Members of this protein family are found in genomes that carry a predicted protein sorting system, PEP-CTERM/exosortase, usually in the vicinity of the EpsH homolog that is the hallmark of the system. The function of this protein is unknown, but it may relate to protein motification. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 163100  Cd Length: 222  Bit Score: 38.61  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822526326  143 VPIFEELIVRGIILHFLQQ---------RFPfWIAAFGSSFLFGIGHIYstgvMFSMFIMGLFMAILCKKTKSIIPAILL 213
Cdd:TIGR03008 127 VPVMEELFWRSFLLRYLQQsdfesvpggRFH-WPSFLAVTLLFGLEHHL----IVAGLIAGLAYNLLLLRTGSIMACILA 201


                  ....*..
gi 822526326  214 HIMNNML 220
Cdd:TIGR03008 202 HAVTNGL 208
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 143-223 1.41e-17

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 74.83  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822526326 143 VPIFEELIVRGIILHFLQQRFPFWIAAFGSSFLFGIGHIYSTGVMFSMFIMGLFMAILCKKTKSIIPAILLHIMNNMLAF 222
Cdd:COG1266   15 APIAEELLFRGYLLGRLRRRFGPWLAILLSSLLFGLLHLPNLLGFLPAFLLGLVLGLLYLRTGSLWVPILLHALNNLLAL 94


                 .
gi 822526326 223 L 223
Cdd:COG1266   95 L 95
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 143-220 2.65e-13

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 63.34  E-value: 2.65e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 822526326  143 VPIFEELIVRGIILHFLQQRFPFWIAAFGSSFLFGIGHIYST-GVMFSMFIMGLFMAILCKKTKSIIPAILLHIMNNML 220
Cdd:pfam02517  14 APIGEELLFRGYLLPRLRRRLWPVLAILISSLLFGLAHLPNGpQLFLLAFLLGLILGYLYLRTGSLWAAILLHALNNLL 92
pepcterm_CAAX TIGR03008
CAAX prenyl protease-related protein; The CAAX prenyl protease, in eukaryotes, catalyzes three ...
 143-220 1.55e-03

CAAX prenyl protease-related protein; The CAAX prenyl protease, in eukaryotes, catalyzes three covalent modifications, including cleavage and acylation, at the C-terminus of certain proteins in a process connected to protein sorting. This family describes a bacterial protein family homologous to one domain of the CAAX-processing enzyme. Members of this protein family are found in genomes that carry a predicted protein sorting system, PEP-CTERM/exosortase, usually in the vicinity of the EpsH homolog that is the hallmark of the system. The function of this protein is unknown, but it may relate to protein motification. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 163100  Cd Length: 222  Bit Score: 38.61  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822526326  143 VPIFEELIVRGIILHFLQQ---------RFPfWIAAFGSSFLFGIGHIYstgvMFSMFIMGLFMAILCKKTKSIIPAILL 213
Cdd:TIGR03008 127 VPVMEELFWRSFLLRYLQQsdfesvpggRFH-WPSFLAVTLLFGLEHHL----IVAGLIAGLAYNLLLLRTGSIMACILA 201


                  ....*..
gi 822526326  214 HIMNNML 220
Cdd:TIGR03008 202 HAVTNGL 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH