|
Name |
Accession |
Description |
Interval |
E-value |
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
1-297 |
1.11e-171 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 477.23 E-value: 1.11e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 1 MRFDNVLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAM 79
Cdd:COG0031 2 RIYDSILELIGNTPLVRLNRLSpGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 80 VAAVKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQE 159
Cdd:COG0031 82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 160 ILQDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVV 239
Cdd:COG0031 162 IWEQTDGKVDAFVAGVGTGGTITGVGRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 827202869 240 QVEAEAAREMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDTGERYL 297
Cdd:COG0031 242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLGPGKTIVTILPDSGERYL 299
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
11-298 |
1.19e-156 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 438.87 E-value: 1.19e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAAVKGYRLI 89
Cdd:cd01561 1 GNTPLVRLNRLSpGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 90 LVMPDSMSVERRRLMLAYGATFELTPREK--GMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEILQDFPEG 167
Cdd:cd01561 81 IVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 168 LDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQVEAEAAR 247
Cdd:cd01561 161 VDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEAF 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 827202869 248 EMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDTGERYLT 298
Cdd:cd01561 241 AMARRLAREEGLLVGGSSGAAVAAALKLAKRLGPGKTIVTILPDSGERYLS 291
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
6-302 |
2.24e-152 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 428.32 E-value: 2.24e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 6 VLQSIGNTPHIRLNRLFGAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAAVKG 85
Cdd:TIGR01139 1 ISELIGNTPLVRLNRIEGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 86 YRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAW-MPQQFENPANIDIHMRATAQEILQDF 164
Cdd:TIGR01139 81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWRDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 165 PEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQVEAE 244
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVSDE 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 827202869 245 AAREMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDTGERYLTVEGF 302
Cdd:TIGR01139 241 EAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEPDKLIVVILPSTGERYLSTPLF 298
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
6-302 |
1.23e-143 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 406.28 E-value: 1.23e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 6 VLQSIGNTPHIRLNRL-FGAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAAVK 84
Cdd:TIGR01136 1 IEELIGNTPLVRLNRLaPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGDTIIEATSGNTGIALAMVAAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 85 GYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEILQDF 164
Cdd:TIGR01136 81 GYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 165 PEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQVEAE 244
Cdd:TIGR01136 161 DGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSDE 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 827202869 245 AAREMARRSAREEGLLVGISSGATLAA---IAQTLpqLPSGARVLGFNYDTGERYLTVEGF 302
Cdd:TIGR01136 241 DAIETARRLAREEGILVGISSGAAVAAalkLAKRL--ENADKVIVAILPDTGERYLSTGLF 299
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
1-298 |
2.02e-101 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 300.24 E-value: 2.02e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 1 MRFDNVLQSIGNTPHIRLNRLFGA-GHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAM 79
Cdd:PRK10717 2 KIFEDVSDTIGNTPLIRLNRASEAtGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 80 VAAVKGYRLILVMPDSMSVERRRLMLAYGATFELTP------REKGMKGAIARAQELCESTPD-AWMPQQFENPANIDIH 152
Cdd:PRK10717 82 VAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPaapyanPNNYVKGAGRLAEELVASEPNgAIWANQFDNPANREAH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 153 MRATAQEILQDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVIS---GG---SPAPHPIQGIGAGFI 226
Cdd:PRK10717 162 YETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyykTGelkAEGSSITEGIGQGRI 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 827202869 227 PRNLDTHLLDGVVQVEAEAAREMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDTGERYLT 298
Cdd:PRK10717 242 TANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARELGPGHTIVTILCDSGERYQS 313
|
|
| PLN02565 |
PLN02565 |
cysteine synthase |
5-298 |
1.85e-99 |
|
cysteine synthase
Pssm-ID: 166206 Cd Length: 322 Bit Score: 294.91 E-value: 1.85e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 5 NVLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTI-IEPTSGNTGIGLAMVAA 82
Cdd:PLN02565 8 DVTELIGKTPLVYLNNVVdGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVlIEPTSGNTGIGLAFMAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 83 VKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEILQ 162
Cdd:PLN02565 88 AKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYETTGPEIWK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 163 DFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQVE 242
Cdd:PLN02565 168 GTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLLDEVVQVS 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 827202869 243 AEAAREMARRSAREEGLLVGISSGATLAAiAQTLPQLP--SGARVLGFNYDTGERYLT 298
Cdd:PLN02565 248 SDEAIETAKLLALKEGLLVGISSGAAAAA-AIKIAKRPenAGKLIVVIFPSFGERYLS 304
|
|
| PLN00011 |
PLN00011 |
cysteine synthase |
4-302 |
2.16e-98 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 292.29 E-value: 2.16e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 4 DNVLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPG-GTIIEPTSGNTGIGLAMVA 81
Cdd:PLN00011 9 NDVTELIGNTPMVYLNNIVdGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEATAGNTGIGLACIG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 82 AVKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEIL 161
Cdd:PLN00011 89 AARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHYRTTGPEIW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 162 QDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQV 241
Cdd:PLN00011 169 RDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLTIVDEIIQV 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 827202869 242 EAEAAREMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDT-GERYLTVEGF 302
Cdd:PLN00011 249 TGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSgGERYLSTKLF 310
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
4-302 |
1.38e-93 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 283.98 E-value: 1.38e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 4 DNVLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTI-IEPTSGNTGIGLAMVA 81
Cdd:PLN03013 115 DNVSQLIGKTPMVYLNSIAkGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVlVEPTSGNTGIGLAFIA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 82 AVKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEIL 161
Cdd:PLN03013 195 ASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIW 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 162 QDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQV 241
Cdd:PLN03013 275 DDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAI 354
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 827202869 242 EAEAAREMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDTGERYLTVEGF 302
Cdd:PLN03013 355 SSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASGRDIYTPRC 415
|
|
| PLP_SbnA_fam |
TIGR03945 |
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a ... |
6-297 |
2.96e-92 |
|
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 274872 [Multi-domain] Cd Length: 304 Bit Score: 276.01 E-value: 2.96e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 6 VLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAAVK 84
Cdd:TIGR03945 1 ILSLIGNTPLVKLERLFpDAPFRLFAKLEGFNPGGSIKDRPALYILEAAIKRGRITPGTTIIESSSGNLGIALAMICAYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 85 GYRLILVMPDSMSVERRRLMLAYGATFELT--PREKG--MKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEI 160
Cdd:TIGR03945 81 GLRFICVVDPNISPQNLKLLRAYGAEVEKVtePDETGgyLGTRIARVRELLASIPDAYWPNQYANPDNPRAHYHGTGREI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 161 LQDFPEgLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASpVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQ 240
Cdd:TIGR03945 161 ARAFPT-LDYLFVGVSTTGTLMGCSRRLRERGPNTKVIAVDAVGS-VIFGGPPGRRHIPGLGASVVPELLDESLIDDVVH 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 827202869 241 V-EAEAAReMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNYDTGERYL 297
Cdd:TIGR03945 239 VpEYDTVA-GCRRLARREGILAGGSSGTVVAAIKRLLPRIPEGSTVVAILPDRGERYL 295
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
4-298 |
1.08e-91 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 276.84 E-value: 1.08e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 4 DNVLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGT-IIEPTSGNTGIGLAMVA 81
Cdd:PLN02556 51 TDASQLIGKTPLVYLNKVTeGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTtLIEPTSGNMGISLAFMA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 82 AVKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQEIL 161
Cdd:PLN02556 131 AMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIW 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 162 QDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQGIGAGFIPRNLDTHLLDGVVQV 241
Cdd:PLN02556 211 EDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVLEV 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 242 EAEAAREMARRSAREEGLLVGISSGA-TLAAIaqTLPQLPS--GARVLGFNYDTGERYLT 298
Cdd:PLN02556 291 SSEDAVNMARELALKEGLMVGISSGAnTVAAL--RLAKMPEnkGKLIVTVHPSFGERYLS 348
|
|
| cysta_beta |
TIGR01137 |
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ... |
4-298 |
3.06e-87 |
|
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273464 [Multi-domain] Cd Length: 455 Bit Score: 268.21 E-value: 3.06e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 4 DNVLQSIGNTPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAA 82
Cdd:TIGR01137 3 DNILDLIGNTPLVRLNKVSkGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPGDTIIEPTSGNTGIGLALVAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 83 VKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGM---KGAIARAQELCESTPDAWMPQQFENPANIDIHMRATAQE 159
Cdd:TIGR01137 83 IKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTPTAAAFdspESHIGVAKRLVREIPGAHILDQYRNPSNPLAHYDTTGPE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 160 ILQDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASpVISGGSP------APHPIQGIGAGFIPRNLDTH 233
Cdd:TIGR01137 163 ILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPEGS-ILAQPEElnqtgrTPYKVEGIGYDFIPTVLDRK 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 827202869 234 LLDGVVQVEAEAAREMARRSAREEGLLVGISSG-ATLAAIAQTLPQLPSGARVLGFNYDTGERYLT 298
Cdd:TIGR01137 242 VVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGsAVVAALKAAEDELQEGQRCVVLLPDSIRNYMT 307
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
1-297 |
4.91e-82 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 249.79 E-value: 4.91e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 1 MRFDNVLQSIGNTPHIRLNRLFGA-GHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAM 79
Cdd:PRK11761 1 MAYPTLEDTIGNTPLVKLQRLPPDrGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPGDTLIEATSGNTGIALAM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 80 VAAVKGYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTpDAWMPQQFENPANIDIHMRATAQE 159
Cdd:PRK11761 81 IAAIKGYRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAEG-EGKVLDQFANPDNPLAHYETTGPE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 160 ILQDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGgspaphpIQGIGAGFIPRNLDTHLLDGVV 239
Cdd:PRK11761 160 IWRQTEGRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEEGSSIPG-------IRRWPEEYLPKIFDASRVDRVL 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 827202869 240 QVEAEAAREMARRSAREEGLLVGISSGATLAA---IAQTLPqlpsGARVLGFNYDTGERYL 297
Cdd:PRK11761 233 DVSQQEAENTMRRLAREEGIFCGVSSGGAVAAalrIARENP----NAVIVAIICDRGDRYL 289
|
|
| cysM |
TIGR01138 |
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ... |
6-298 |
4.81e-77 |
|
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]
Pssm-ID: 130208 [Multi-domain] Cd Length: 290 Bit Score: 236.73 E-value: 4.81e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 6 VLQSIGNTPHIRLNRLFG-AGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAAVK 84
Cdd:TIGR01138 2 IEQTVGNTPLVRLQRMGPeNGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 85 GYRLILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAWMpQQFENPANIDIHMRATAQEILQDF 164
Cdd:TIGR01138 82 GYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGKLL-DQFNNPDNPYAHYTSTGPEIWQQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 165 PEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGgspaphpIQGIGAGFIPRNLDTHLLDGVVQVEAE 244
Cdd:TIGR01138 161 GGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEEGSSIPG-------IRRWPTEYLPGIFDASLVDRVLDIHQR 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 827202869 245 AAREMARRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVLGFNyDTGERYLT 298
Cdd:TIGR01138 234 DAENTMRELAVREGIFCGVSSGGAVAAALRLARELPDAVVVAIIC-DRGDRYLS 286
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
13-286 |
7.10e-77 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 234.72 E-value: 7.10e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 13 TPHIRLNRLF-GAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALrPGGTIIEPTSGNTGIGLAMVAAVKGYRLILV 91
Cdd:cd00640 1 TPLVRLKRLSkLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL-PKGVIIESTGGNTGIALAAAAARLGLKCTIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 92 MPDSMSVERRRLMLAYGATFELTPreKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHmRATAQEILQDFPEG-LDV 170
Cdd:cd00640 80 MPEGASPEKVAQMRALGAEVVLVP--GDFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQ-GTIGLEILEQLGGQkPDA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 171 LITGVGTGGHITGCARVLKQAWPRLKVLAVEPsaspvisggspaphpiqgigagfiprnldthlldGVVQVEAEAAREMA 250
Cdd:cd00640 157 VVVPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------EVVTVSDEEALEAI 202
|
250 260 270
....*....|....*....|....*....|....*.
gi 827202869 251 RRSAREEGLLVGISSGATLAAIAQTLPQLPSGARVL 286
Cdd:cd00640 203 RLLAREEGILVEPSSAAALAAALKLAKKLGKGKTVV 238
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
6-286 |
1.41e-75 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 233.36 E-value: 1.41e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 6 VLQSIGNTPHIRLNRLFGA-GHEVWIKSERANPGGSIKDRIALAMVEDAERSgalRPGGTIIEPTSGNTGIGLAMVAAVK 84
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKElGVDVYLKLESLNPTGSFKDRGALNLLLRLKEG---EGGKTVVEASSGNHGRALAAAAARL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 85 GYRLILVMPDSMSVERRRLMLAYGATFELTprEKGMKGAIARAQELCESTPDAWMPQQFENPANIDIHmRATAQEILQDF 164
Cdd:pfam00291 78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLV--GGDYDEAVAAARELAAEGPGAYYINQYDNPLNIEGY-GTIGLEILEQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 165 PEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVISGG---------SPAPHPIQGIGAGFIPRNLDTHLL 235
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDLL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 827202869 236 ----DGVVQVEAEAAREMARRSAREEGLLVGISSGATLAAIAQTL-PQLPSGARVL 286
Cdd:pfam00291 235 deyvGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALaGELKGGDRVV 290
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
6-305 |
3.20e-39 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 142.44 E-value: 3.20e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 6 VLQSIGNTPHIRLNRLFGA-GHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGGTIIEPTSGNTGIGLAMVAAVK 84
Cdd:PLN02356 47 LIDAIGNTPLIRINSLSEAtGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPGGVVTEGSAGSTAISLATVAPAY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 85 GYRLILVMPDSMSVERRRLMLAYGATFE------LTPREKGMKGAIARAQELCE-------------------------- 132
Cdd:PLN02356 127 GCKCHVVIPDDVAIEKSQILEALGATVErvrpvsITHKDHYVNIARRRALEANElaskrrkgsetdgihlektngcisee 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 133 ---------STPDAWMPQQFENPANIDIHMRATAQEILQDFPEGLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPS 203
Cdd:PLN02356 207 ekenslfssSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDPP 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 204 ASPV---ISGG--------------SPAPHPIQGIGAGFIPRNLDTHLLDGVVQVEAEAAREMARRSAREEGLLVGISSG 266
Cdd:PLN02356 287 GSGLfnkVTRGvmytreeaegrrlkNPFDTITEGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLKNDGLFVGSSSA 366
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 827202869 267 ATLAAIAQTLPQLPSGARVLGFNYDTGER---------YLTVEGFLPT 305
Cdd:PLN02356 367 MNCVGAVRVAQSLGPGHTIVTILCDSGMRhlskfhdpqYLSQHGLTPT 414
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
11-274 |
4.41e-18 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 83.71 E-value: 4.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRLFGA-GHEVWIKSERANPGGSIKDRiALAM-VEDAERSGALrpggTIIEPTSGNTGIGLAMVAAVKGYRL 88
Cdd:COG0498 65 GGTPLVKAPRLADElGKNLYVKEEGHNPTGSFKDR-AMQVaVSLALERGAK----TIVCASSGNGSAALAAYAARAGIEV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 89 ILVMP-DSMSVERRRLMLAYGATFELtprekgMKGAIARAQELCE--STPDAWMpqqFENPANIdihMRATAQ-----EI 160
Cdd:COG0498 140 FVFVPeGKVSPGQLAQMLTYGAHVIA------VDGNFDDAQRLVKelAADEGLY---AVNSINP---ARLEGQktyafEI 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 161 LQDFPEGLDVLITGVGTGGHITGCARVLKQAW--------PRLkvLAVEPS-ASPV---ISGGSPAPHPIQG-------- 220
Cdd:COG0498 208 AEQLGRVPDWVVVPTGNGGNILAGYKAFKELKelglidrlPRL--IAVQATgCNPIltaFETGRDEYEPERPetiapsmd 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 827202869 221 IGagfIPRNLDtHLLD-------GVVQVEAEAAREMARRSAREEGLLVGISSGATLAAIAQ 274
Cdd:COG0498 286 IG---NPSNGE-RALFalresggTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLRK 342
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
13-286 |
4.82e-17 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 80.08 E-value: 4.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 13 TPHIRLNRL-FGAGHEVWIKSERANPGGSIKDRIALAMVedAERSGALRPGGtIIEPTSGNTGIGLAMVAAVKGYRLILV 91
Cdd:COG1171 25 TPLLRSPTLsERLGAEVYLKLENLQPTGSFKLRGAYNAL--ASLSEEERARG-VVAASAGNHAQGVAYAARLLGIPATIV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 92 MPDSMSVERRRLMLAYGATFELTPR---EkgmkgAIARAQELCEST-----PDawmpqqFENPaniDIhMR--AT-AQEI 160
Cdd:COG1171 102 MPETAPAVKVAATRAYGAEVVLHGDtydD-----AEAAAAELAEEEgatfvHP------FDDP---DV-IAgqGTiALEI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 161 LQDFPEgLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPV----ISGGSPAPHPIQ-----GIGAGFI-PRNL 230
Cdd:COG1171 167 LEQLPD-LDAVFVPVGGGGLIAGVAAALKALSPDIRVIGVEPEGAAAmyrsLAAGEPVTLPGVdtiadGLAVGRPgELTF 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 827202869 231 DT--HLLDGVVQV-EAEAAREMaRRSAREEGLLVGISSGATLAAIAQTLPQLPsGARVL 286
Cdd:COG1171 246 EIlrDLVDDIVTVsEDEIAAAM-RLLLERTKIVVEPAGAAALAALLAGKERLK-GKRVV 302
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
17-272 |
5.80e-17 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 79.45 E-value: 5.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 17 RLNRLFGAghEVWIKSERANPGGSIKDRIALAMV----EDAERSGalrpggtIIEPTSGNTGIGLAMVAAVKGYRLILVM 92
Cdd:cd01562 25 TLSELLGA--EVYLKCENLQKTGSFKIRGAYNKLlslsEEERAKG-------VVAASAGNHAQGVAYAAKLLGIPATIVM 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 93 PDSMSVERRRLMLAYGATFELTprEKGMKGAIARAQELCESTPDAWMPqqfenPANiDIHMRA----TAQEILQDFPEgL 168
Cdd:cd01562 96 PETAPAAKVDATRAYGAEVVLY--GEDFDEAEAKARELAEEEGLTFIH-----PFD-DPDVIAgqgtIGLEILEQVPD-L 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 169 DVLITGVGTGGHITGCARVLKQAWPRLKVLAVEPSASPVIS----GGSPAPHPIQGIGA--------GFIPRNLDTHLLD 236
Cdd:cd01562 167 DAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAqslaAGKPVTLPEVDTIAdglavkrpGELTFEIIRKLVD 246
|
250 260 270
....*....|....*....|....*....|....*.
gi 827202869 237 GVVQVEAEAAREMARRSAREEGLLVGISSGATLAAI 272
Cdd:cd01562 247 DVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAAL 282
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
11-272 |
4.43e-14 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 71.47 E-value: 4.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRL--FGAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGAlrpgGTIIEPTSGNTGIGLAMVAAVKGYRL 88
Cdd:cd01563 21 GNTPLVRAPRLgeRLGGKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGV----KAVACASTGNTSASLAAYAARAGIKC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 89 ILVMPDSMSVERRRLMLAYGATfeLTPREKGMKGAIARAQELCESTPdaWMPQQFENPanIDIHMRAT-AQEILQDFPEG 167
Cdd:cd01563 97 VVFLPAGKALGKLAQALAYGAT--VLAVEGNFDDALRLVRELAEENW--IYLSNSLNP--YRLEGQKTiAFEIAEQLGWE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 168 L-DVLITGVGTGGHITGCARVLKQAW--------PRLkvLAVEPS-ASPVISG---GSPAPHPI-------QGIGAGFiP 227
Cdd:cd01563 171 VpDYVVVPVGNGGNITAIWKGFKELKelglidrlPRM--VGVQAEgAAPIVRAfkeGKDDIEPVenpetiaTAIRIGN-P 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 827202869 228 RNLDTHL-----LDG-VVQVEAEAAREMARRSAREEGLLVGISSGATLAAI 272
Cdd:cd01563 248 ASGPKALravreSGGtAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGL 298
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
11-109 |
1.92e-10 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 60.49 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRLFGAGH--EVWIKSERANPGGSIKDRIALAMVEDAERSGAlrpgGTIIEPTSGNTGIGLAMVAAVKGYRL 88
Cdd:PRK06381 14 GGTPLLRARKLEEELGlrKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY----SGITVGTCGNYGASIAYFARLYGLKA 89
|
90 100
....*....|....*....|.
gi 827202869 89 ILVMPDSMSVERRRLMLAYGA 109
Cdd:PRK06381 90 VIFIPRSYSNSRVKEMEKYGA 110
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
18-202 |
5.05e-10 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 59.40 E-value: 5.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 18 LNRLFGagHEVWIKSERANPGGSIKDRIALAMVEDAERSGalRPGGTIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSMS 97
Cdd:PRK06608 32 LNEMLG--HEIFFKVESLQKTGAFKVRGVLNHLLELKEQG--KLPDKIVAYSTGNHGQAVAYASKLFGIKTRIYLPLNTS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 98 VERRRLMLAYGATFELTPREKGMKGAIARAQElcestPDA-WMPqqfenPANID--IHMRAT-AQEILQDFPEGLDVLIT 173
Cdd:PRK06608 108 KVKQQAALYYGGEVILTNTRQEAEEKAKEDEE-----QGFyYIH-----PSDSDstIAGAGTlCYEALQQLGFSPDAIFA 177
|
170 180
....*....|....*....|....*....
gi 827202869 174 GVGTGGHITGCARVLKQAWPRLKVLAVEP 202
Cdd:PRK06608 178 SCGGGGLISGTYLAKELISPTSLLIGSEP 206
|
|
| ilvA_1Cterm |
TIGR01127 |
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ... |
25-272 |
6.77e-10 |
|
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130197 [Multi-domain] Cd Length: 380 Bit Score: 59.37 E-value: 6.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 25 GHEVWIKSERANPGGSIKDRIAL----AMVEDAERSGalrpggtIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSMSVER 100
Cdd:TIGR01127 14 GSEVYLKLENLQKTGSFKIRGALnkiaNLSEDQRQRG-------VVAASAGNHAQGVAYAAKKFGIKAVIVMPESAPPSK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 101 RRLMLAYGAtfELTPREKGMKGAIARAQELCESTpdawmPQQFENPANiDIHMRA----TAQEILQDFPEgLDVLITGVG 176
Cdd:TIGR01127 87 VKATKSYGA--EVILHGDDYDEAYAFATSLAEEE-----GRVFVHPFD-DEFVMAgqgtIGLEIMEDIPD-VDTVIVPVG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 177 TGGHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQ---------GIG---AGFIPRNLDTHLLDGVVQV-EA 243
Cdd:TIGR01127 158 GGGLISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAvesvrtiadGIAvkkPGDLTFNIIKEYVDDVVTVdEE 237
|
250 260 270
....*....|....*....|....*....|
gi 827202869 244 EAAREMARrsAREEGLLVGISSGAT-LAAI 272
Cdd:TIGR01127 238 EIANAIYL--LLERHKILAEGAGAAgVAAL 265
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
28-287 |
9.64e-10 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 58.87 E-value: 9.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 28 VWIKSERANPGGSIKDRIAL-AMVEDAERsGALRPggtIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSMSVERRRLMLA 106
Cdd:PRK08813 50 VWLKLENLQRTGSYKVRGALnALLAGLER-GDERP---VICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAH 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 107 YGATFeltpREKG--MKGAIARAQELCESTPDAWMpQQFENP------ANIDIHMRATAQeilqdfpeglDVLITGVGTG 178
Cdd:PRK08813 126 WGATV----RQHGnsYDEAYAFARELADQNGYRFL-SAFDDPdviagqGTVGIELAAHAP----------DVVIVPIGGG 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 179 GHITGCARVLKQAWPRLKVLAVE--PSASPVISGGSPAPHPIQGIG-------AGFIPRNLDTHLLDGVVQVEAEAAREM 249
Cdd:PRK08813 191 GLASGVALALKSQGVRVVGAQVEgvDSMARAIRGDLREIAPVATLAdgvkvkiPGFLTRRLCSSLLDDVVIVREAELRET 270
|
250 260 270
....*....|....*....|....*....|....*...
gi 827202869 250 ARRSAREEGLlvgISSGATLAAIAqtlpqlpSGARVLG 287
Cdd:PRK08813 271 LVRLALEEHV---IAEGAGALALA-------AGRRVSG 298
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
11-305 |
1.33e-09 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 58.47 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRL---FGAGhEVWIKSERANPGGSIKDRIALAMVEDAERSGALRpggtIIEPTSGNTGIGLAMVAAVKGYR 87
Cdd:PRK08197 78 GMTPLLPLPRLgkaLGIG-RLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKH----LAMPTNGNAGAAWAAYAARAGIR 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 88 LILVMPDSMSVERRRLMLAYGATFELTPREKGMKGAIARAQELCESTPDAwmpQQFENPANIDiHMRATAQEILQDFPEG 167
Cdd:PRK08197 153 ATIFMPADAPEITRLECALAGAELYLVDGLISDAGKIVAEAVAEYGWFDV---STLKEPYRIE-GKKTMGLELAEQLGWR 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 168 L-DVLI--TGVGTGghITGCARVLKQ----AW---PRLKVLAVEPSA-SPVISG-------GSPAPHPiQGIGAGF-IPR 228
Cdd:PRK08197 229 LpDVILypTGGGVG--LIGIWKAFDElealGWiggKRPRLVAVQAEGcAPIVKAweegkeeSEFWEDA-HTVAFGIrVPK 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 229 NL-DTHLLDGV-------VQVEAEAAREMARRSAREEGLLVGISSGATLAAIAQTLPQ--LPSGARVLGFNYDTGERY-L 297
Cdd:PRK08197 306 ALgDFLVLDAVretggcaIAVSDDAILAAQRELAREEGLFACPEGAATFAAARQLRESgwLKGDERVVLFNTGSGLKYpD 385
|
....*...
gi 827202869 298 TVEGFLPT 305
Cdd:PRK08197 386 TVPVVVPV 393
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
11-109 |
1.04e-08 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 55.97 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRLFGAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRpggtIIEPTSGNTGIGLAMVAAVKGYRLIL 90
Cdd:PRK05638 65 GGTPLIRARISEKLGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAANG----FIVASDGNAAASVAAYSARAGKEAFV 140
|
90
....*....|....*....
gi 827202869 91 VMPDSMSVERRRLMLAYGA 109
Cdd:PRK05638 141 VVPRKVDKGKLIQMIAFGA 159
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
25-205 |
1.37e-08 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 55.57 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 25 GHEVWIKSERANPGGSIKDRIA---LAMVEDAERSGAlrpggtIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSMSVERR 101
Cdd:PRK12483 51 GNQVLLKREDLQPVFSFKIRGAynkMARLPAEQLARG------VITASAGNHAQGVALAAARLGVKAVIVMPRTTPQLKV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 102 RLMLAYGAtfELTPREKGMKGAIARAQELCESTPDAWMPqQFENPANIdIHMRATAQEILQDFPEGLDVLITGVGTGGHI 181
Cdd:PRK12483 125 DGVRAHGG--EVVLHGESFPDALAHALKLAEEEGLTFVP-PFDDPDVI-AGQGTVAMEILRQHPGPLDAIFVPVGGGGLI 200
|
170 180
....*....|....*....|....
gi 827202869 182 TGCARVLKQAWPRLKVLAVEPSAS 205
Cdd:PRK12483 201 AGIAAYVKYVRPEIKVIGVEPDDS 224
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
13-272 |
1.63e-08 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 54.96 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 13 TPHIRLNRLFGAGHEVWIKSERANPGGSIKDRIALAMVEdaersGALRPGGTIIEPTSGNTGIGLAMVAAVKGYRLILVM 92
Cdd:PRK08246 24 TPVLEADGAGFGPAPVWLKLEHLQHTGSFKARGAFNRLL-----AAPVPAAGVVAASGGNAGLAVAYAAAALGVPATVFV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 93 PDSMSVERRRLMLAYGATFELTPREKG--MKGAIARAQElcestPDAWMPQQFENPAnIDIHMRATAQEILQDFPeGLDV 170
Cdd:PRK08246 99 PETAPPAKVARLRALGAEVVVVGAEYAdaLEAAQAFAAE-----TGALLCHAYDQPE-VLAGAGTLGLEIEEQAP-GVDT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 171 LITGVGTGGHITGCArvlkqAW--PRLKVLAVEPSASPV----ISGGSPAPHPIQGIGA--------GFIPRNLDTHLLD 236
Cdd:PRK08246 172 VLVAVGGGGLIAGIA-----AWfeGRARVVAVEPEGAPTlhaaLAAGEPVDVPVSGIAAdslgarrvGEIAFALARAHVV 246
|
250 260 270
....*....|....*....|....*....|....*.
gi 827202869 237 GVVQVEAEAAREMARRSAREEGLLVGISSGATLAAI 272
Cdd:PRK08246 247 TSVLVSDEAIIAARRALWEELRLAVEPGAATALAAL 282
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
18-250 |
2.07e-08 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 54.90 E-value: 2.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 18 LNRLFGAghEVWIKSERANPGGSIKDRIA---LAMVEDAERSGAlrpggtIIEPTSGNTGIGLAMVAAVKGYRLILVMPD 94
Cdd:PRK07334 32 LSQITGA--EVWLKFENLQFTASFKERGAlnkLLLLTEEERARG------VIAMSAGNHAQGVAYHAQRLGIPATIVMPR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 95 S---MSVERRRLMLA----YGATFEltprekgmkGAIARAQELCEstpdawmpQQ---FENPANiDIHMRA----TAQEI 160
Cdd:PRK07334 104 FtptVKVERTRGFGAevvlHGETLD---------EARAHARELAE--------EEgltFVHPYD-DPAVIAgqgtVALEM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 161 LQDFPEgLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVE----PSASPVISGgspAPHPI------QGIGA---GFIP 227
Cdd:PRK07334 166 LEDAPD-LDTLVVPIGGGGLISGMATAAKALKPDIEIIGVQtelyPSMYAAIKG---VALPCggstiaEGIAVkqpGQLT 241
|
250 260
....*....|....*....|...
gi 827202869 228 RNLDTHLLDGVVQVEaEAAREMA 250
Cdd:PRK07334 242 LEIVRRLVDDILLVS-EADIEQA 263
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
24-278 |
3.69e-08 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 53.93 E-value: 3.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 24 AGHEVWIKSERANPGGSIKDRIA----LAMVEDAERSGalrpggtIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSMSVE 99
Cdd:PRK06815 33 TGCEVYLKCEHLQHTGSFKFRGAsnklRLLNEAQRQQG-------VITASSGNHGQGVALAAKLAGIPVTVYAPEQASAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 100 RRRLMLAYGATFELTPREKGMKGAIARAQELCESTPdawmpqqFENPANiDIHMRA----TAQEILQDFPeGLDVLITGV 175
Cdd:PRK06815 106 KLDAIRALGAEVRLYGGDALNAELAARRAAEQQGKV-------YISPYN-DPQVIAgqgtIGMELVEQQP-DLDAVFVAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 176 GTGGHITGCARVLKQAWPRLKVLAVEPSASPV----ISGGSPAPHPIQ---------GIGAGFIPRNLDTHLLDGVVQVE 242
Cdd:PRK06815 177 GGGGLISGIATYLKTLSPKTEIIGCWPANSPSlytsLEAGEIVEVAEQptlsdgtagGVEPGAITFPLCQQLIDQKVLVS 256
|
250 260 270
....*....|....*....|....*....|....*.
gi 827202869 243 AEAAREMARRSAREEGLLVGISSGATLAAIAQTLPQ 278
Cdd:PRK06815 257 EEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPR 292
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
18-204 |
4.09e-08 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 53.48 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 18 LNRLFGAghEVWIKSERANPGGSIKDR---IALAMVEDAERsgalRPGgtIIEPTSGNTGIGLAMVAAVKGYRLILVMPD 94
Cdd:PRK07048 33 ADARTGA--QVFFKCENFQRMGAFKFRgayNALSQFSPEQR----RAG--VVTFSSGNHAQAIALSARLLGIPATIVMPQ 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 95 SMSVERRRLMLAYGATFELTPREKGMKGAIARaqELCESTPDAWMPQqFENPanidiHMRA----TAQEILQDFPEgLDV 170
Cdd:PRK07048 105 DAPAAKVAATRGYGGEVVTYDRYTEDREEIGR--RLAEERGLTLIPP-YDHP-----HVIAgqgtAAKELFEEVGP-LDA 175
|
170 180 190
....*....|....*....|....*....|....
gi 827202869 171 LITGVGTGGHITGCARVLKQAWPRLKVLAVEPSA 204
Cdd:PRK07048 176 LFVCLGGGGLLSGCALAARALSPGCKVYGVEPEA 209
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
25-202 |
6.42e-08 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 53.60 E-value: 6.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 25 GHEVWIKSERANPGGSIKDRIALAMVedAERSGALRPGGtIIEPTSGNTGIGLAMVAAVKGYRLILVMPD---SMSVER- 100
Cdd:PRK09224 34 GNQVLLKREDLQPVFSFKLRGAYNKM--AQLTEEQLARG-VITASAGNHAQGVALSAARLGIKAVIVMPVttpDIKVDAv 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 101 RRL---MLAYGATFEltprekgmkGAIARAQELCESTPDAWMPQqFENPANIdihmrA----TAQEILQDFPEGLDVLIT 173
Cdd:PRK09224 111 RAFggeVVLHGDSFD---------EAYAHAIELAEEEGLTFIHP-FDDPDVI-----AgqgtIAMEILQQHPHPLDAVFV 175
|
170 180
....*....|....*....|....*....
gi 827202869 174 GVGTGGHITGCARVLKQAWPRLKVLAVEP 202
Cdd:PRK09224 176 PVGGGGLIAGVAAYIKQLRPEIKVIGVEP 204
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
24-110 |
1.50e-07 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 51.92 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 24 AGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALRPGgtIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSMSVERRRL 103
Cdd:PRK06110 34 LGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPRVRG--VISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAA 111
|
....*..
gi 827202869 104 MLAYGAT 110
Cdd:PRK06110 112 MRALGAE 118
|
|
| PLN02970 |
PLN02970 |
serine racemase |
18-205 |
7.40e-07 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 49.68 E-value: 7.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 18 LNRLfgAGHEVWIKSERANPGGSIKDRIALAMV-----EDAERSgalrpggtIIEPTSGNTGIGLAMVAAVKGYRLILVM 92
Cdd:PLN02970 36 LDAL--AGRSLFFKCECFQKGGAFKFRGACNAIfslsdDQAEKG--------VVTHSSGNHAAALALAAKLRGIPAYIVV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 93 PDSMSVERRRLMLAYGAtfELTPREKGMKGAIARAQELCESTPDAWMPQqFENPaNIdIHMRAT-AQEILQDFPEgLDVL 171
Cdd:PLN02970 106 PKNAPACKVDAVIRYGG--IITWCEPTVESREAVAARVQQETGAVLIHP-YNDG-RV-ISGQGTiALEFLEQVPE-LDVI 179
|
170 180 190
....*....|....*....|....*....|....
gi 827202869 172 ITGVGTGGHITGCARVLKQAWPRLKVLAVEPSAS 205
Cdd:PLN02970 180 IVPISGGGLISGIALAAKAIKPSIKIIAAEPKGA 213
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
25-203 |
8.30e-07 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 50.30 E-value: 8.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 25 GHEVWIKSERANPGGSIKDRIALAMVEDAERSgALRPGgtIIEPTSGNTGIGLAMVAAVKGYRLILVMPDSM------SV 98
Cdd:PLN02550 123 GVKVLLKREDLQPVFSFKLRGAYNMMAKLPKE-QLDKG--VICSSAGNHAQGVALSAQRLGCDAVIAMPVTTpeikwqSV 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 99 ERrrlmlaYGATFELTprEKGMKGAIARAQELCESTPDAWMPqQFENPaNIDIHMRATAQEILQDFPEGLDVLITGVGTG 178
Cdd:PLN02550 200 ER------LGATVVLV--GDSYDEAQAYAKQRALEEGRTFIP-PFDHP-DVIAGQGTVGMEIVRQHQGPLHAIFVPVGGG 269
|
170 180
....*....|....*....|....*
gi 827202869 179 GHITGCARVLKQAWPRLKVLAVEPS 203
Cdd:PLN02550 270 GLIAGIAAYVKRVRPEVKIIGVEPS 294
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
12-272 |
9.83e-07 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 49.60 E-value: 9.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 12 NTPHIR---LNRLfgAGHEVWIKSERANPGGSIKDR-IALAMVEDAERSGALRPGgtIIEPTSGNTGIGLAMVAAVKGYR 87
Cdd:cd06448 1 KTPLIEstaLSKT--AGCNVFLKLENLQPSGSFKIRgIGHLCQKSAKQGLNECVH--VVCSSGGNAGLAAAYAARKLGVP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 88 LILVMPDS---MSVERRRLmlaYGATFELTPREKGmKGAIARAQELCESTPDAWMPQQFENPANIDIHmrAT-AQEILQD 163
Cdd:cd06448 77 CTIVVPEStkpRVVEKLRD---EGATVVVHGKVWW-EADNYLREELAENDPGPVYVHPFDDPLIWEGH--SSmVDEIAQQ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 164 FPEG--LDVLITGVGTGGHITGCARVLKQA-WPRLKVLAVEPSASPVISGGSPAPHPIQ---------GIGAG------- 224
Cdd:cd06448 151 LQSQekVDAIVCSVGGGGLLNGIVQGLERNgWGDIPVVAVETEGAHSLNASLKAGKLVTlpkitsvatSLGAKtvssqal 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 827202869 225 --FIPRNLDTHLLDgvvQVEAEAAREmarRSAREEGLLVGISSGATLAAI 272
Cdd:cd06448 231 eyAQEHNIKSEVVS---DRDAVQACL---RFADDERILVEPACGAALAVV 274
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
11-129 |
1.64e-06 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 48.96 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRlnrlfgaGHEVWIKSERANPGGSIKDRIALAMVEDAERSGAlrpgGTIIEPTSGNTGIGLAMVAAVKGYRLIL 90
Cdd:PRK06450 57 GRTPLIK-------KGNIWFKLDFLNPTGSYKDRGSVTLISYLAEKGI----KQISEDSSGNAGASIAAYGAAAGIEVKI 125
|
90 100 110
....*....|....*....|....*....|....*....
gi 827202869 91 VMPDSMSVERRRLMLAYGAtfELTpREKGMKGAIARAQE 129
Cdd:PRK06450 126 FVPETASGGKLKQIESYGA--EVV-RVRGSREDVAKAAE 161
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
13-201 |
1.05e-05 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 46.27 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 13 TPHIRLNRLFGAGH-EVWIKSERANPGGSIKDRIA---LAMVEDAERsgalRPGgtIIEPTSGNTGIGLAMVAAVKGYRL 88
Cdd:PRK08638 28 TPLPRSNYLSERCKgEIFLKLENMQRTGSFKIRGAfnkLSSLTDAEK----RKG--VVACSAGNHAQGVALSCALLGIDG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 89 ILVMPDSMSVERRRLMLAYGAtfELTPREKGMKGAIARAQELCESTPDAWMPqQFENPANIdihmraTAQ-----EILQD 163
Cdd:PRK08638 102 KVVMPKGAPKSKVAATCGYGA--EVVLHGDNFNDTIAKVEEIVEEEGRTFIP-PYDDPKVI------AGQgtiglEILED 172
|
170 180 190
....*....|....*....|....*....|....*...
gi 827202869 164 FPEgLDVLITGVGTGGHITGCARVLKQAWPRLKVLAVE 201
Cdd:PRK08638 173 LWD-VDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQ 209
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
11-182 |
1.17e-05 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 46.22 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHIRLNRLFG--AGHEVWIKSERANPGGSIKDRIALAMVEDAERSGALrpggTIIEPTSGNTGIGLAMVAAVKGYRL 88
Cdd:TIGR00260 21 GVTPLFRAPALAAnvGIKNLYVKELGHNPTLSFKDRGMAVALTKALELGND----TVLCASTGNTGAAAAAYAGKAGLKV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 89 ILVMP-DSMSVERRRLMLAYGATFeltpreKGMKGAIARAQELCESTPDAwMPQQFENPANIDIHmRATAQ-----EILQ 162
Cdd:TIGR00260 97 VVLYPaGKISLGKLAQALGYNAEV------VAIDGNFDDAQRLVKQLFED-KPALGLNSANSIPY-RLEGQktyafEAVE 168
|
170 180
....*....|....*....|.
gi 827202869 163 DFP-EGLDVLITGVGTGGHIT 182
Cdd:TIGR00260 169 QLGwEAPDKVVVPVPNSGNFG 189
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
24-261 |
4.79e-05 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 44.19 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 24 AGHEVWIKSERANPGGSIKDRIALAMVedAERSGALRPGGTIIEPTsGNTGIGLAMVAAVKGYRLILVM----PDSMSVE 99
Cdd:PRK07476 32 AGVPVWLKLETLQPTGSFKLRGATNAL--LSLSAQERARGVVTAST-GNHGRALAYAARALGIRATICMsrlvPANKVDA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 100 RRRLmlayGATFELTPREKgmKGAIARAQELCESTPDAWMPQqFENPANIdiHMRAT-AQEILQDFPEgLDVLITGVGTG 178
Cdd:PRK07476 109 IRAL----GAEVRIVGRSQ--DDAQAEVERLVREEGLTMVPP-FDDPRII--AGQGTiGLEILEALPD-VATVLVPLSGG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 179 GHITGCARVLKQAWPRLKVLAVEPSASPVISGGSPAPHPIQ-------------GIGagfiprnLDTH--------LLDG 237
Cdd:PRK07476 179 GLASGVAAAVKAIRPAIRVIGVSMERGAAMHASLAAGRPVQveevptladslggGIG-------LDNRytfamcraLLDD 251
|
250 260
....*....|....*....|....*
gi 827202869 238 VVQV-EAEAAREMaRRSAREEGLLV 261
Cdd:PRK07476 252 VVLLdEAEIAAGI-RHAYREERLVV 275
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
11-110 |
1.18e-04 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 43.26 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827202869 11 GNTPHI---RLNRLFGAGHEVWIKSERANPGGSIKDRIALAMVEDAERSGAL-RPGGTIIEPTSGNTGIGLAMVAAVKGY 86
Cdd:PLN02569 132 GNSNLFwaeRLGKEFLGMNDLWVKHCGISHTGSFKDLGMTVLVSQVNRLRKMaKPVVGVGCASTGDTSAALSAYCAAAGI 211
|
90 100
....*....|....*....|....*
gi 827202869 87 RLILVMP-DSMSVERRRLMLAYGAT 110
Cdd:PLN02569 212 PSIVFLPaDKISIAQLVQPIANGAL 236
|
|
| |
