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Conserved domains on  [gi|829938270|ref|WP_047367414|]
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MULTISPECIES: response regulator [Enterobacter]

Protein Classification

response regulator( domain architecture ID 1002978)

response regulator receives the signal from a sensor partner in two-component systems through its receiver (REC) domain, similar to CitB family transcriptional regulators

CATH:  3.40.50.2300
Gene Ontology:  GO:0000160|GO:0000156
PubMed:  20226724
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dpiA super family cl32452
two-component response regulator DpiA; Provisional
 4-226 3.23e-61

two-component response regulator DpiA; Provisional


The actual alignment was detected with superfamily member PRK10046:

Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 191.38  E-value: 3.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   4 ELIDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVI 83
Cdd:PRK10046   3 APLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQfaeQQRVWKIVD---QQNVDSLYQLQAKNYRLDNGSKGI 160
Cdd:PRK10046  83 FTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQ---RKHMLESIDsasQKQIDEMFNAYARGEPKDELPTGI 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 829938270 161 EENTLARVQTLFNSKAAHcFTVDEVVSETGLSKTTTRRYLEHCVEVGFLTVEMLYGKIGHPRRMYR 226
Cdd:PRK10046 160 DPLTLNAVRKLFKEPGVQ-HTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
 
Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 4-226 3.23e-61

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 191.38  E-value: 3.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   4 ELIDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVI 83
Cdd:PRK10046   3 APLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQfaeQQRVWKIVD---QQNVDSLYQLQAKNYRLDNGSKGI 160
Cdd:PRK10046  83 FTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQ---RKHMLESIDsasQKQIDEMFNAYARGEPKDELPTGI 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 829938270 161 EENTLARVQTLFNSKAAHcFTVDEVVSETGLSKTTTRRYLEHCVEVGFLTVEMLYGKIGHPRRMYR 226
Cdd:PRK10046 160 DPLTLNAVRKLFKEPGVQ-HTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 6-136 2.05e-42

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 140.49  E-value: 2.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFI 85
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRVWKIVD 136
Cdd:COG4565   84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEED 134
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 6-122 2.70e-38

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 129.29  E-value: 2.70e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFI 85
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERF 122
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRLERY 117
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-120 1.86e-14

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 67.18  E-value: 1.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270    8 VLIVEDENELAQLHAELIGKhPRLRlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpMLAR--ANCSVIFI 85
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEK-EGYV-VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLK--RIRRrdPTTPVIIL 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 829938270   86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLE 120
Cdd:pfam00072  77 TAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 8-62 5.53e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 36.78  E-value: 5.53e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 829938270     8 VLIVEDENELAQLHAELIGKHPrlRLVGIAASLADAQRQLESKQPKLMLLDNYLP 62
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEG--YEVDEATDGEEALELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 4-226 3.23e-61

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 191.38  E-value: 3.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   4 ELIDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVI 83
Cdd:PRK10046   3 APLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQfaeQQRVWKIVD---QQNVDSLYQLQAKNYRLDNGSKGI 160
Cdd:PRK10046  83 FTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQ---RKHMLESIDsasQKQIDEMFNAYARGEPKDELPTGI 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 829938270 161 EENTLARVQTLFNSKAAHcFTVDEVVSETGLSKTTTRRYLEHCVEVGFLTVEMLYGKIGHPRRMYR 226
Cdd:PRK10046 160 DPLTLNAVRKLFKEPGVQ-HTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 6-136 2.05e-42

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 140.49  E-value: 2.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFI 85
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRVWKIVD 136
Cdd:COG4565   84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEED 134
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 6-122 2.70e-38

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 129.29  E-value: 2.70e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFI 85
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERF 122
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRLERY 117
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-139 4.25e-22

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 90.65  E-value: 4.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFI 85
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 829938270  86 TAASDMDTcsQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRVWKIVDQQN 139
Cdd:COG3279   82 TAYDEYAL--EAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEK 133
PRK10430 PRK10430
two-component system response regulator DcuR;
5-226 1.70e-21

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 89.01  E-value: 1.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   5 LIDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQL-ESKQP-KLMLLDNYLPDGKGITLISNPMLARANCSV 82
Cdd:PRK10430   1 MINVLIVDDDAMVAELNRRYVAQIPGFQCCGTASTLEQAKEIIfNSDTPiDLILLDIYMQQENGLDLLPVLHEAGCKSDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  83 IFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRVWKIVDQQNVDSLYQLQAKNY----RLdngSK 158
Cdd:PRK10430  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEqdprRL---PK 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 829938270 159 GIEENTLARVQTLFNSKAAHCFTVDEVVSETGLSKTTTRRYLEHCVEVGFLTVEMLYGKIGHPRRMYR 226
Cdd:PRK10430 158 GLTPQTLRTLCQWIDAHQDYEFSTDELANAVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYR 225
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 8-130 1.39e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 86.17  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELigkhprLRLVG----IAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVI 83
Cdd:COG2204    5 ILVVDDDPDIRRLLKEL------LERAGyeveTAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQR 130
Cdd:COG2204   79 LLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRR 125
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 8-109 5.53e-17

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 73.65  E-value: 5.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILSG 81

                         90       100
                 ....*....|....*....|..
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKP 109
Cdd:COG4753   82 YSDFEYAQEAIKLGADDYLLKP 103
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 9-109 2.50e-16

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 71.49  E-value: 2.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   9 LIVEDENELAQLHAELIGKHPRLrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpmLARA---NCSVIFI 85
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYE--VDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLR---KLRElppDIPVIVL 75

                         90       100
                 ....*....|....*....|....
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd00156   76 TAKADEEDAVRALELGADDYLVKP 99
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 8-119 2.91e-16

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 72.23  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAE-LIGKHPRLRlvgIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFIT 86
Cdd:cd17572    1 VLLVEDSPSLAALYQEyLSDEGYKVT---HVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 829938270  87 AASDMDTCSQAIRNGAFDYILKPVSWKRLSQSL 119
Cdd:cd17572   78 AHGSVDIAVEAMRLGAYDFLEKPFDADRLRVTV 110
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 8-130 6.26e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 70.96  E-value: 6.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRlRLVgIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLIS--NPMLARANCSVIFI 85
Cdd:COG3437    9 VLIVDDDPENLELLRQLLRTLGY-DVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRllRADPSTRDIPVIFL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQR 130
Cdd:COG3437   87 TALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQR 131
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 8-125 1.33e-14

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 69.17  E-value: 1.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHpRLRLVgIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLI----SNPmlARANCSVI 83
Cdd:COG3706    4 ILVVDDDPTNRKLLRRLLEAA-GYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCrrlrADP--RTADIPII 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQF 125
Cdd:COG3706   80 FLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVARY 121
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-120 1.86e-14

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 67.18  E-value: 1.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270    8 VLIVEDENELAQLHAELIGKhPRLRlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpMLAR--ANCSVIFI 85
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEK-EGYV-VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLK--RIRRrdPTTPVIIL 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 829938270   86 TAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLE 120
Cdd:pfam00072  77 TAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 8-122 3.09e-14

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 66.79  E-value: 3.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE----NELAqlhaELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpMLARANCS-- 81
Cdd:cd17532    1 ALIVDDEplarEELR----YLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAK--KLSKLAKPpl 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 829938270  82 VIFITAASDMDTcsQAIRNGAFDYILKPVSWKRLSQSLERF 122
Cdd:cd17532   75 IVFVTAYDEYAV--EAFELNAVDYLLKPFSEERLAEALAKL 113
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 8-121 2.67e-13

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 64.06  E-value: 2.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELI---GKHprlrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIF 84
Cdd:cd17550    1 ILIVDDEEDIRESLSGILedeGYE-----VDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIM 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  85 ITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLER 121
Cdd:cd17550   76 ISGHGTIETAVKATKLGAYDFIEKPLSLDRLLLTIER 112
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 8-124 5.94e-13

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 63.13  E-value: 5.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKH-PRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLI-----SNPmlaraNCS 81
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEeLGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIekireLYP-----DIK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829938270  82 VIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQ 124
Cdd:cd17536   76 IIILSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKE 118
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 8-124 8.51e-13

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 62.95  E-value: 8.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELigkhprLRLVGI----AASLADAQRQLESKQPKLMLLDNYLPDGKGITLISN--PMLARANCS 81
Cdd:COG0784    8 ILVVDDNPDNRELLRRL------LERLGYevttAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRirALPRLPDIP 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829938270  82 VIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQ 124
Cdd:COG0784   82 IIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLA 124
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 8-115 2.66e-12

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 61.50  E-value: 2.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE---NELAQLHAELIGKHPRLrlvgiAASLADAQRQLESKQPKLMLLDNYLPDGKGITLI----SNPMLARAnc 80
Cdd:cd17618    3 ILIVEDEpaiREMIAFNLERAGFDVVE-----AEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIrrlkRDEMTRDI-- 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 829938270  81 SVIFITAASDMDTCSQAIRNGAFDYILKPVSWKRL 115
Cdd:cd17618   76 PIIMLTARGEEEDKVRGLEAGADDYITKPFSPREL 110
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 8-129 3.96e-12

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 62.63  E-value: 3.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKhpRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:COG4567    7 LLLVDDDEAFARVLARALER--RGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQ 129
Cdd:COG4567   85 YASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAP 126
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 8-111 4.27e-12

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 60.99  E-value: 4.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDEnELAQ--LHAeLIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFI 85
Cdd:cd17535    1 VLIVDDH-PLVRegLRR-LLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVL 78

                         90       100
                 ....*....|....*....|....*.
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17535   79 TAHDDPEYVLRALKAGAAGYLLKDSS 104
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 34-121 7.82e-12

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 60.37  E-value: 7.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  34 VGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITAASDMDTCSQAIRNGAFDYILKPVSWK 113
Cdd:cd17542   28 VGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPE 107


                 ....*...
gi 829938270 114 RLSQSLER 121
Cdd:cd17542  108 RVLEAVEK 115
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 8-131 1.18e-11

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 61.51  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELigkhprLRLVG----IAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpmLARANCS-- 81
Cdd:COG0745    4 ILVVEDDPDIRELLADA------LEREGyevdTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCR---RLRARPSdi 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829938270  82 -VIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRV 131
Cdd:COG0745   75 pIIMLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVL 125
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 6-111 2.98e-11

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 58.57  E-value: 2.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDEnelaqlhaELIGKHPRLRL-------VGIAASLADAQRQLESKQPKLMLLDNYLPDGK-GITL---ISNpm 74
Cdd:cd17534    1 KKILIVEDE--------AIIALDLKEILeslgyevVGIADSGEEAIELAEENKPDLILMDINLKGDMdGIEAareIRE-- 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  75 laRANCSVIFITAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17534   71 --KFDIPVIFLTAYSDEETLERAKETNPYGYLVKPFN 105
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 8-109 5.91e-11

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 57.55  E-value: 5.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHpRLRLVGiAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRM-GLDVRS-ARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITA 78

                         90       100
                 ....*....|....*....|..
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd19926   79 YGSLDTAIEALKAGAFDFLTKP 100
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 6-109 4.68e-10

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 55.31  E-value: 4.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLP--DGKGI--TLISNPMLARANcs 81
Cdd:cd17561    2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPhlDGIGVleKLRRMRLEKRPK-- 79

                         90       100
                 ....*....|....*....|....*...
gi 829938270  82 VIFITAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd17561   80 IIMLTAFGQEDITQRAVELGASYYILKP 107
PRK11697 PRK11697
two-component system response regulator BtsR;
6-131 5.53e-10

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 57.55  E-value: 5.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDE----NELAqlhaELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpMLARANC- 80
Cdd:PRK11697   2 IKVLIVDDEplarEELR----ELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVG--MLDPEHMp 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829938270  81 SVIFITAASDMDTcsQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRV 131
Cdd:PRK11697  76 YIVFVTAFDEYAI--KAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDV 124
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
1-128 1.47e-09

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 57.35  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   1 MQHELIDVLIVEDE-NELAQLHAELIGKHPRlrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARAN 79
Cdd:PRK10365   1 MTHDNIDILVVDDDiSHCTILQALLRGWGYN---VALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPA 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 829938270  80 CSVIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQ 128
Cdd:PRK10365  78 IPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHS 126
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 31-130 1.89e-09

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 55.49  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  31 LRLVGIAASL-ADAQ---RQLESKQPKLMLLDNYLPDGKGITLISnpMLARANCS--VIFITAASDMDTCSQAIRNGAFD 104
Cdd:COG4566   19 LESAGLRVETfASAEaflAALDPDRPGCLLLDVRMPGMSGLELQE--ELAARGSPlpVIFLTGHGDVPMAVRAMKAGAVD 96

                         90       100
                 ....*....|....*....|....*.
gi 829938270 105 YILKPVSWKRLSQSLERFVQFAEQQR 130
Cdd:COG4566   97 FLEKPFDDQALLDAVRRALARDRARR 122
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 8-111 2.56e-09

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 53.22  E-value: 2.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKhpRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:cd17563    3 LLLVDDDEVFAERLARALER--RGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80

                         90       100
                 ....*....|....*....|....
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17563   81 YASIATAVEAIKLGADDYLAKPAD 104
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 8-110 3.43e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 52.51  E-value: 3.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE-NELAQLHAELIGKHPRlrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGI----TLISNPmlARANCSV 82
Cdd:cd19920    1 ILIVDDVpDNLRLLSELLRAAGYR---VLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFevcrRLKADP--ATRHIPV 75

                         90       100
                 ....*....|....*....|....*...
gi 829938270  83 IFITAASDMDTCSQAIRNGAFDYILKPV 110
Cdd:cd19920   76 IFLTALTDTEDKVKGFELGAVDYITKPF 103
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 9-109 3.76e-09

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 52.41  E-value: 3.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   9 LIVEDENELAQLHAELIGKHprlrlvG----IAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpMLaRANCS--- 81
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKE------GyevdTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCR--RL-REKGSdip 71

                         90       100
                 ....*....|....*....|....*...
gi 829938270  82 VIFITAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd17574   72 IIMLTAKDEEEDKVLGLELGADDYITKP 99
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 7-91 4.98e-09

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 52.64  E-value: 4.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   7 DVLIVEDENELAqLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDG-KGITLIsNPMLARANCSVIFI 85
Cdd:cd17540    2 RVLIIEDEPLIA-MDLEQIVEDLGHQVVGIARTRDEAVALARRERPDLILADIQLADGsSGIDAV-NEILTTHDVPVIFV 79


                 ....*.
gi 829938270  86 TAASDM 91
Cdd:cd17540   80 TAYPER 85
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 37-109 7.25e-09

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 52.28  E-value: 7.25e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 829938270  37 AASLADAQR---QLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd19919   27 VTSFENAQEalaALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPKP 102
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 8-130 1.28e-08

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 53.04  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHpRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVIFITA 87
Cdd:COG3707    6 VLVVDDEPLRRADLREGLREA-GYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQ-ISEERPAPVILLTA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFV-QFAEQQR 130
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALELALaRFRELRA 127
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
8-152 3.24e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 53.31  E-value: 3.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPrLRLVGiAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQG-FETHC-ANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTA 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWkrlsQSLERFVQFAEQQRVWKivdqQNVDSLYQLQAKNYR 152
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVIKPFDL----DELNLIVQRALQLQSMK----KEIRHLHQALSTSWQ 141
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 6-111 4.37e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 50.08  E-value: 4.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMlARANCSVIFI 85
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIM-AERPTPVVMV 79

                         90       100
                 ....*....|....*....|....*...
gi 829938270  86 TA--ASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17541   80 SSltEEGAEITLEALELGAVDFIAKPSG 107
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 8-130 5.72e-08

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 49.80  E-value: 5.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELigkhprLRLVGI----AASLADAQRQLESKQPKLMLLDNYLPDGKGITLisnpmLARANCS-- 81
Cdd:cd17549    1 VLLVDDDADVREALQQT------LELAGFrvraFADAEEALAALSPDFPGVVISDIRMPGMDGLEL-----LAQIRELdp 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 829938270  82 ---VIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERfvqfAEQQR 130
Cdd:cd17549   70 dlpVILITGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRR----ALEKR 117
PRK09191 PRK09191
two-component response regulator; Provisional
 7-87 6.20e-08

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 51.77  E-value: 6.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   7 DVLIVEDEN----ELAQLHAELiGkHprlRLVGIAASLADAQRQLESKQPKLMLLDNYLPDG-KGITLIsNPMLARANCS 81
Cdd:PRK09191 139 RVLIIEDEPiiamDLEQLVESL-G-H---RVTGIARTRAEAVALAKKTRPGLILADIQLADGsSGIDAV-NDILKTFDVP 212


                 ....*.
gi 829938270  82 VIFITA 87
Cdd:PRK09191 213 VIFITA 218
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 8-115 7.69e-08

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 49.35  E-value: 7.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpmlARANCSVIFITA 87
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQ--ADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSR---IKEKHPSIVVIV 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 829938270  88 ASDMDTCSQ---AIRNGAFDYILKPVSWKRL 115
Cdd:cd17573   76 LSDNPKTEQeieAFKEGADDYIAKPFDFKVL 106
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 6-71 1.17e-07

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 49.12  E-value: 1.17e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLIS 71
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALR 67
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 8-109 1.26e-07

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 48.64  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpmlARANCS---VIF 84
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYA--VDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRR---WRRQGQslpVLI 75

                         90       100
                 ....*....|....*....|....*
gi 829938270  85 ITAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd17624   76 LTARDGVDDRVAGLDAGADDYLVKP 100
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 8-115 3.94e-07

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 47.37  E-value: 3.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIgKHPRLRlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITlISNPMLARANCSVIFITA 87
Cdd:cd19939    2 ILIVEDELELARLTRDYL-IKAGLE-VSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLT-VCREVREHSHVPILMLTA 78

                         90       100
                 ....*....|....*....|....*....
gi 829938270  88 ASD-MDTCsQAIRNGAFDYILKPVSWKRL 115
Cdd:cd19939   79 RTEeMDRV-LGLEMGADDYLCKPFSPREL 106
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 41-111 4.02e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 47.20  E-value: 4.02e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 829938270  41 ADAQRQLE---SKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17555   31 ADGRQGLElfrSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGAGVMSDAVEALRLGAWDYLTKPIE 104
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 10-110 7.49e-07

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 46.11  E-value: 7.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  10 IVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITAAS 89
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQVS 82

                         90       100
                 ....*....|....*....|.
gi 829938270  90 DMDTCSQAIRNGAFDYILKPV 110
Cdd:cd17565   83 DKEMIGKAYQAGIEFFINKPI 103
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 8-111 7.80e-07

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 46.60  E-value: 7.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPrlRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVIFITA 87
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHG--FNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRD-LRPKYQGPILLLTA 79

                         90       100
                 ....*....|....*....|....*
gi 829938270  88 -ASDMDTCsQAIRNGAFDYILKPVS 111
Cdd:cd17622   80 lDSDIDHI-LGLELGADDYVVKPVE 103
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 8-108 1.78e-06

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 45.63  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRlVGIAASLADAQRQLESKQPKLM-LLDNYLPD---GKGITLIsnpmLARANCSVI 83
Cdd:cd19921    2 VLIVEDSKTFSKVLKHLIAQELGLE-VDVAETLAEAKALLEEGDDYFAaLVDLNLPDapnGEAVDLV----LEKGIPVIV 76

                         90       100
                 ....*....|....*....|....*
gi 829938270  84 FiTAASDMDTCSQAIRNGAFDYILK 108
Cdd:cd19921   77 L-TGSFDEDKRETLLSKGVVDYVLK 100
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 47-130 1.78e-06

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 47.94  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  47 LESKQPKLMLLDNYLPDGKGITLI-----SNPMLArancsVIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLER 121
Cdd:PRK10923  43 LASKTPDVLLSDIRMPGMDGLALLkqikqRHPMLP-----VIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVER 117

                         90
                 ....*....|
gi 829938270 122 FV-QFAEQQR 130
Cdd:PRK10923 118 AIsHYQEQQQ 127
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 8-111 1.81e-06

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 45.35  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLhaelIGKHprLRLVG----IAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVI 83
Cdd:cd18159    1 ILIVEDDETIASL----LKKH--LEKWGyevvLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCRE-IRQISNVPII 73

                         90       100
                 ....*....|....*....|....*....
gi 829938270  84 FITAASD-MDTCsQAIRNGAFDYILKPVS 111
Cdd:cd18159   74 FISSRDDnMDQV-MAINMGGDDYITKPFD 101
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 8-110 2.31e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 45.13  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE--NELaqLHAELIGKHPRLRLVGIAASLaDAQRQLESKQPKLMLLDNYLPDGKGITLIS--NPMLARANCSVI 83
Cdd:cd17551    3 ILIVDDNptNLL--LLEALLRSAGYLEVVSFTDPR-EALAWCRENPPDLILLDYMMPGMDGLEFIRrlRALPGLEDVPIV 79

                         90       100
                 ....*....|....*....|....*..
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPV 110
Cdd:cd17551   80 MITADTDREVRLRALEAGATDFLTKPF 106
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 8-121 3.11e-06

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 44.96  E-value: 3.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLER 121
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRT 114
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 8-111 3.43e-06

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 44.68  E-value: 3.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLhaeligKHPRLRLVGIAASL----ADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVI 83
Cdd:cd19938    2 ILIVEDEPKLAQL------LIDYLRAAGYAPTLlahgDQVLPYVRHTPPDLILLDLMLPGTDGLTLCRE-IRRFSDVPII 74

                         90       100
                 ....*....|....*....|....*...
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd19938   75 MVTARVEEIDRLLGLELGADDYICKPYS 102
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 8-109 4.20e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 44.11  E-value: 4.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPrlRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGiTLISNPMLARANCSVIFITA 87
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEG--FEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSG-TEVCRQLRARSNVPVIMVTA 77

                         90       100
                 ....*....|....*....|..
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd17621   78 KDSEIDKVVGLELGADDYVTKP 99
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 8-109 5.11e-06

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 44.03  E-value: 5.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHP-RLRLVGIAASLadaQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFIT 86
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGyEVRTTGNAATL---WRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMS 77

                         90       100
                 ....*....|....*....|...
gi 829938270  87 AASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd19928   78 AQNTLMTAVKAAERGAFEYLPKP 100
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 8-121 5.93e-06

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 45.79  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSV 88

                         90       100       110
                 ....*....|....*....|....*....|....
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLER 121
Cdd:PRK10651  89 SNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQ 122
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 31-121 7.26e-06

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 43.74  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  31 LRLVGIAASL-ADAQRQLESKQPKL---MLLDNYLPDGKGITLISnpMLARANCS--VIFITAASDMDTCSQAIRNGAFD 104
Cdd:cd17537   20 LRSVGLAVKTfTSASAFLAAAPPDQpgcLVLDVRMPGMSGLELQD--ELLARGSNipIIFITGHGDVPMAVEAMKAGAVD 97

                         90
                 ....*....|....*..
gi 829938270 105 YILKPVSWKRLSQSLER 121
Cdd:cd17537   98 FLEKPFRDQVLLDAIEQ 114
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 8-109 1.16e-05

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 42.92  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQ-LHAELIGKHPRLRlvgIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISnpMLaR--ANCSVIF 84
Cdd:cd17620    1 ILVIEDEPQIRRfLRTALEAHGYRVF---EAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIR--RL-RewSAVPVIV 74

                         90       100
                 ....*....|....*....|....*
gi 829938270  85 ITAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd17620   75 LSARDEESDKIAALDAGADDYLTKP 99
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 8-108 1.21e-05

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 45.01  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKH-------PRlrlvgiaaslAD-AQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARAN 79
Cdd:PRK10701   4 IVFVEDDAEVGSLIAAYLAKHdidvtvePR----------GDrAEATILREQPDLVLLDIMLPGKDGMTICRD-LRPKWQ 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 829938270  80 CSVIFITAA-SDMDTCsQAIRNGAFDYILK 108
Cdd:PRK10701  73 GPIVLLTSLdSDMNHI-LALEMGACDYILK 101
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 7-122 1.46e-05

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 44.41  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   7 DVLIVEDENElaqlhaelIGKHPRLRLVGIAASLADA---QRQL---ESKQPKLMLLDNYLPDGKGITLISNpMLARANC 80
Cdd:PRK10529   3 NVLIVEDEQA--------IRRFLRTALEGDGMRVFEAetlQRGLleaATRKPDLIILDLGLPDGDGIEFIRD-LRQWSAI 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829938270  81 SVIFITAASDMDTCSQAIRNGAFDYILKPVS----WKRLSQSLERF 122
Cdd:PRK10529  74 PVIVLSARSEESDKIAALDAGADDYLSKPFGigelQARLRVALRRH 119
PRK10693 PRK10693
two-component system response regulator RssB;
42-119 1.59e-05

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 44.98  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  42 DAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCS-VIFITAASDMDTCSQAIRNGAFDYILKPVS-WKRLSQSL 119
Cdd:PRK10693   8 DALELLGGFTPDLIICDLAMPRMNGIEFVEH-LRNRGDQTpVLVISATENMADIAKALRLGVQDVLLKPVKdLNRLREMV 86
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 8-121 1.82e-05

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 42.72  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGI-TLisnPMLARANCS--VIF 84
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLdTL---KALREEGVSarIVI 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  85 ITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLER 121
Cdd:cd19931   78 LTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQ 114
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 8-111 1.90e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 42.72  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAEligkhpRLRLVG----IAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVI 83
Cdd:cd17615    2 VLVVDDEPNITELLSM------ALRYEGwdveTAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVL 75

                         90       100
                 ....*....|....*....|....*...
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17615   76 FLTAKDSVEDRIAGLTAGGDDYVTKPFS 103
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
8-140 2.00e-05

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 44.32  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE---NELAQLHAELIGKHPRLrlvgiAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpmLARA----NC 80
Cdd:PRK10161   5 ILVVEDEapiREMVCFVLEQNGFQPVE-----AEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKH--LKREsmtrDI 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  81 SVIFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQFAEQQRVWKIVDQQNV 140
Cdd:PRK10161  78 PVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGL 137
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 8-120 2.22e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 42.40  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRlRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLisnpmlARANCS-----V 82
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGY-EVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEA------AKIITSeniapI 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 829938270  83 IFITAASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLE 120
Cdd:cd19932   76 VLLTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIE 113
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 8-109 4.88e-05

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 41.52  E-value: 4.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGkhPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVIFITA 87
Cdd:cd17623    1 ILLIDDDRELTELLTEYLE--MEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKE-LRKTSQVPVLMLTA 77

                         90       100
                 ....*....|....*....|...
gi 829938270  88 -ASDMDTCSqAIRNGAFDYILKP 109
Cdd:cd17623   78 rGDDIDRIL-GLELGADDYLPKP 99
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 8-110 5.16e-05

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 40.94  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE-NELAQLHAELIGKHPRLRLvgiAASLADAQRQLESKQPKLMLLDNYLPDGKGIT----LISNPMLAraNCSV 82
Cdd:cd17538    2 ILVVDDEpANRELLEALLSAEGYEVLT---ADSGQEALALAEEELPDLILLDVMMPGMDGFEvcrrLKEDPETR--HIPV 76

                         90       100
                 ....*....|....*....|....*...
gi 829938270  83 IFITAASDMDTCSQAIRNGAFDYILKPV 110
Cdd:cd17538   77 IMITALDDREDRIRGLEAGADDFLSKPI 104
PRK13435 PRK13435
response regulator; Provisional
 8-121 8.34e-05

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 41.19  E-value: 8.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAqLHAELIGKHPRLRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:PRK13435   8 VLIVEDEALIA-LELEKLVEEAGHEVVGIAMSSEQAIALGRRRQPDVALVDVHLADGPTGVEVARRLSADGGVEVVFMTG 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  88 ASDM---DTcsqairNGAFDYILKPVSWKRLSQSLER 121
Cdd:PRK13435  87 NPERvphDF------AGALGVIAKPYSPRGVARALSY 117
PRK15369 PRK15369
two component system response regulator;
6-108 1.21e-04

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 41.60  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHPRLRLVG-IAASLA--DAQRQLEskqPKLMLLDNYLPDGKGITLIsnPMLAR--ANC 80
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYPRYKIVGqVDNGLEvyNACRQLE---PDIVILDLGLPGMNGLDVI--PQLHQrwPAM 78

                         90       100
                 ....*....|....*....|....*...
gi 829938270  81 SVIFITAASDMDTCSQAIRNGAFDYILK 108
Cdd:PRK15369  79 NILVLTARQEEHMASRTLAAGALGYVLK 106
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 8-115 1.40e-04

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 40.06  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVIFITA 87
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQEGYD--VSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRE-LREQSEVGIILVTG 79

                         90       100
                 ....*....|....*....|....*...
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWKRL 115
Cdd:cd17619   80 RDDEVDRIVGLEIGADDYVTKPFNPREL 107
CitT pfam12431
Transcriptional regulator; This domain family is found in bacteria, and is approximately 30 ...
 135-163 1.60e-04

Transcriptional regulator; This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with pfam00072. There is a single completely conserved residue G that may be functionally important. CitT is a transcriptional regulator which allows transcription of the citM gene which codes for the secondary transporter in the Mg-citrate transport complex.


Pssm-ID: 432549  Cd Length: 30  Bit Score: 37.85  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 829938270  135 VDQQNVDSLYQLQAKNYRLDNGS-KGIEEN 163
Cdd:pfam12431   1 VDQSDVDRLFQLQAKGAPPSGDLpKGIDKL 30
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 8-115 2.35e-04

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 39.38  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQ-----LHAEliGKHPRLRLVGIAASLAdaqrqLESKQPKLMLLDNYLPDGKGITlISNPMLARANCSV 82
Cdd:cd17626    3 ILVVDDDAALAEmigivLRGE--GFDPAFCGDGTQALAA-----FREVRPDLVLLDLMLPGIDGIE-VCRQIRAESGVPI 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 829938270  83 IFITAASDMDTCSQAIRNGAFDYILKPVSWKRL 115
Cdd:cd17626   75 VMLTAKSDTVDVVLGLESGADDYVAKPFKPKEL 107
orf27 CHL00148
Ycf27; Reviewed
 8-115 3.71e-04

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 40.47  E-value: 3.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAEligkhpRLRLVGI----AASLADAQRQLESKQPKLMLLDNYLP--DGKGITlisNPMLARANCS 81
Cdd:CHL00148   9 ILVVDDEAYIRKILET------RLSIIGYevitASDGEEALKLFRKEQPDLVILDVMMPklDGYGVC---QEIRKESDVP 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 829938270  82 VIFITAASDMDTCSQAIRNGAFDYILKPVSWKRL 115
Cdd:CHL00148  80 IIMLTALGDVSDRITGLELGADDYVVKPFSPKEL 113
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
181-230 4.17e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.29  E-value: 4.17e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 829938270 181 TVDEVVSETGLSKTTTRRYLEHCVEVGFLTVEMLYGKIGHPRRMYRRAEA 230
Cdd:COG2345   29 TAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRGRPAKLYRLTEA 78
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 8-62 5.53e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 36.78  E-value: 5.53e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 829938270     8 VLIVEDENELAQLHAELIGKHPrlRLVGIAASLADAQRQLESKQPKLMLLDNYLP 62
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEG--YEVDEATDGEEALELLKEEKPDLILLDIMMP 55
PRK10643 PRK10643
two-component system response regulator PmrA;
8-109 5.64e-04

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 39.63  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQ---LHAELIGkhprlRLVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpmLARANCS--V 82
Cdd:PRK10643   3 ILIVEDDTLLLQgliLALQTEG-----YACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRR--WRQKKYTlpV 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 829938270  83 IFITAasdMDTCSQAIRN---GAFDYILKP 109
Cdd:PRK10643  76 LILTA---RDTLEDRVAGldvGADDYLVKP 102
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-120 6.92e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 38.27  E-value: 6.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   6 IDVLIVEDENELAQLHAELIGKHpRLRlVGIAASLADAQRQLESkQP--KLMLLDNYLPDGKGITLISN--PMLARANCS 81
Cdd:cd17544    1 IKVLVVDDSATSRNHLRALLRRH-NFQ-VLEAANGQEALEVLEQ-HPdiKLVITDYNMPEMDGFELVREirKKYSRDQLA 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829938270  82 VIFITAASDMDTCSQAIRNGAFDYILKPVSWK----RLSQSLE 120
Cdd:cd17544   78 IIGISASGDNALSARFIKAGANDFLTKPFLPEefycRVTQNLE 120
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 8-110 8.38e-04

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 37.81  E-value: 8.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRLVgiAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNpMLARANCSVIFITA 87
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTA--AADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRT-IRARSDVPIIIISG 78

                         90       100
                 ....*....|....*....|....*..
gi 829938270  88 ----ASDMDTcsqAIRNGAFDYILKPV 110
Cdd:cd17594   79 drrdEIDRVV---GLELGADDYLAKPF 102
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 54-111 1.30e-03

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 37.22  E-value: 1.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270  54 LMLLDNYLPDGKGITLISnpmLARANCS--VIFITAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:cd17584   47 LVITDVHMPDMDGFEFLE---LIRLEMDlpVIMMSADGSTSTVMKGLAHGACDYLLKPVS 103
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 8-111 1.69e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 38.51  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAE-LIGKHPRLRLVGIAASLADAQRQlesKQPKLMLLDNYLPDGKGITLISNpmLAR-ANCSVIFI 85
Cdd:PRK10710  13 ILIVEDEPKLGQLLIDyLQAASYATTLLSHGDEVLPYVRQ---TPPDLILLDLMLPGTDGLTLCRE--IRRfSDIPIVMV 87

                         90       100
                 ....*....|....*....|....*.
gi 829938270  86 TAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:PRK10710  88 TAKIEEIDRLLGLEIGADDYICKPYS 113
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 8-87 2.12e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 36.76  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDE---NELAQLHAELIGKHPrlrlVGIAASLADAQRQLESKQPKLMLLDNYLPDGKGIT----LISNPmlARANC 80
Cdd:cd17552    4 ILVIDDEediREVVQACLEKLAGWE----VLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLAtlkkLQANP--ETQSI 77


                 ....*..
gi 829938270  81 SVIFITA 87
Cdd:cd17552   78 PVILLTA 84
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 8-109 2.46e-03

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 36.26  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELaqlhAELIGKhpRLRLVGIAASLA----DAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVI 83
Cdd:cd19935    1 ILVVEDEKKL----AEYLKK--GLTEEGYAVDVAydgeDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVL 74

                         90       100
                 ....*....|....*....|....*.
gi 829938270  84 FITAASDMDTCSQAIRNGAFDYILKP 109
Cdd:cd19935   75 MLTARDSVEDRVKGLDLGADDYLVKP 100
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 8-111 3.82e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 37.25  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQ-----LHAEliGKHPRLRLVGIAAsLADAQRQleskQPKLMLLDNYLPDGKGITLISNPMLARANCSV 82
Cdd:PRK11083   6 ILLVEDEQAIADtlvyaLQSE--GFTVEWFERGLPA-LDKLRQQ----PPDLVILDVGLPDISGFELCRQLLAFHPALPV 78

                         90       100
                 ....*....|....*....|....*....
gi 829938270  83 IFITAASDMDTCSQAIRNGAFDYILKPVS 111
Cdd:PRK11083  79 IFLTARSDEVDRLVGLEIGADDYVAKPFS 107
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 8-119 4.12e-03

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 36.09  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDenelaQLHAELIGKHpRLRLVGI-----AASLADAQRQLESKQPKLMLLDNYLpdGKGIT-------LISNPML 75
Cdd:cd17589    1 FLIVDD-----QPTFRSMLKS-MLRSLGVtridtASSGEEALRMCENKTYDIVLCDYNL--GKGKNgqqlleeLRHKKLI 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 829938270  76 ARaNCSVIFITAASdmdtcSQAIRNGAF-----DYILKPVSWKRLSQSL 119
Cdd:cd17589   73 SP-STVFIMVTGES-----SRAMVLSALelepdDYLLKPFTVSELRERL 115
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 9-115 4.85e-03

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 35.71  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   9 LIVEDENELAqlhaELIGKHprLRLVGIAASLA----DAQRQLESKQPKLMLLDNYLPDGKGI----TLISNPMLARAnc 80
Cdd:cd19937    1 LVVDDEEDIV----ELLKYN--LEKEGYEVVTAydgeEALKRAKDEKPDLIILDLMLPGIDGLevcrILRSDPKTSSI-- 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 829938270  81 SVIFITAASDMDTCSQAIRNGAFDYILKPVSWKRL 115
Cdd:cd19937   73 PIIMLTAKGEEFDKVLGLELGADDYITKPFSPREL 107
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 8-119 6.86e-03

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 35.13  E-value: 6.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELigkhprLRLVG----IAASLADAQRQLESKQPKLMLLDNYLPDGKGITLI----SNPMLARAn 79
Cdd:cd17580    1 ILVVDDNEDAAEMLALL------LELEGaevtTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELArrlrELPWLANT- 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 829938270  80 cSVIFITA-ASDMDTcSQAIRNGaFD-YILKPVSWKRLSQSL 119
Cdd:cd17580   74 -PAIALTGyGQPEDR-ERALEAG-FDaHLVKPVDPDELIELI 112
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
181-229 6.97e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 35.71  E-value: 6.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 829938270 181 TVDEVVSETGLSKTTTRRYLEHCVEVGFLTVEMLYGKIGHPRRMYRRAE 229
Cdd:COG3355   44 TVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEGGGYPYVYYAID 92
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 8-121 7.07e-03

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 35.21  E-value: 7.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDeNELAQLHAELIgkhprLRLVGI----AASLADAQRQLESKQPKLMLLDNYLPDGKGITLI----SNPmlARAN 79
Cdd:cd17548    2 ILIVED-NPLNMKLARDL-----LESAGYevleAADGEEALEIARKEKPDLILMDIQLPGMDGLEATrllkEDP--ATRD 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829938270  80 CSVIFITAASdMDTCSQAIRNGAFD-YILKPVSWKRLSQSLER 121
Cdd:cd17548   74 IPVIALTAYA-MKGDREKILEAGCDgYISKPIDTREFLETVAK 115
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 8-124 7.54e-03

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 35.22  E-value: 7.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829938270   8 VLIVEDENELAQLHAELIGKHPRLRLVgiAASLADAQRQLESKQPKLMLLDNYLPDGKGITLISNPMLARANCSVIFITA 87
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQTFQ--AANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 829938270  88 ASDMDTCSQAIRNGAFDYILKPVSWKRLSQSLERFVQ 124
Cdd:cd17553   81 YGELDMIQESKELGALTHFAKPFDIDEIRDAVKKYLP 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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